LOCUS       NM_003762               4977 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens vesicle associated membrane protein 4 (VAMP4),
            transcript variant 1, mRNA.
ACCESSION   NM_003762
VERSION     NM_003762.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4977)
  AUTHORS   Li,M., Feng,F., Feng,H., Hu,P., Xue,Y., Xu,T. and Song,E.
  TITLE     VAMP4 regulates insulin levels by targeting secretory granules to
            lysosomes
  JOURNAL   J Cell Biol 221 (10) (2022)
   PUBMED   36053215
  REMARK    GeneRIF: VAMP4 regulates insulin levels by targeting secretory
            granules to lysosomes.
REFERENCE   2  (bases 1 to 4977)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 4977)
  AUTHORS   Brown,E.E., Blauwendraat,C., Trinh,J., Rizig,M., Nalls,M.A.,
            Leveille,E., Ruskey,J.A., Jonvik,H., Tan,M.M.X., Bandres-Ciga,S.,
            Hassin-Baer,S., Brockmann,K., Infante,J., Tolosa,E., Ezquerra,M.,
            Ben Romdhan,S., Benmahdjoub,M., Arezki,M., Mhiri,C., Hardy,J.,
            Singleton,A.B., Alcalay,R.N., Gasser,T., Grosset,D.G.,
            Williams,N.M., Pittman,A., Gan-Or,Z., Fernandez-Santiago,R.,
            Brice,A., Lesage,S., Farrer,M., Wood,N. and Morris,H.R.
  CONSRTM   International Parkinson Disease Genomics Consortium (IPDGC)
  TITLE     Analysis of DNM3 and VAMP4 as genetic modifiers of LRRK2
            Parkinson's disease
  JOURNAL   Neurobiol Aging 97, 148 (2021)
   PUBMED   32873436
  REMARK    GeneRIF: Analysis of DNM3 and VAMP4 as genetic modifiers of LRRK2
            Parkinson's disease.
REFERENCE   4  (bases 1 to 4977)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   5  (bases 1 to 4977)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   6  (bases 1 to 4977)
  AUTHORS   Mallard,F., Tang,B.L., Galli,T., Tenza,D., Saint-Pol,A., Yue,X.,
            Antony,C., Hong,W., Goud,B. and Johannes,L.
  TITLE     Early/recycling endosomes-to-TGN transport involves two SNARE
            complexes and a Rab6 isoform
  JOURNAL   J Cell Biol 156 (4), 653-664 (2002)
   PUBMED   11839770
REFERENCE   7  (bases 1 to 4977)
  AUTHORS   Peden,A.A., Park,G.Y. and Scheller,R.H.
  TITLE     The Di-leucine motif of vesicle-associated membrane protein 4 is
            required for its localization and AP-1 binding
  JOURNAL   J Biol Chem 276 (52), 49183-49187 (2001)
   PUBMED   11598115
REFERENCE   8  (bases 1 to 4977)
  AUTHORS   Scales,S.J., Chen,Y.A., Yoo,B.Y., Patel,S.M., Doung,Y.C. and
            Scheller,R.H.
  TITLE     SNAREs contribute to the specificity of membrane fusion
  JOURNAL   Neuron 26 (2), 457-464 (2000)
   PUBMED   10839363
REFERENCE   9  (bases 1 to 4977)
  AUTHORS   Steegmaier,M., Klumperman,J., Foletti,D.L., Yoo,J.S. and
            Scheller,R.H.
  TITLE     Vesicle-associated membrane protein 4 is implicated in trans-Golgi
            network vesicle trafficking
  JOURNAL   Mol Biol Cell 10 (6), 1957-1972 (1999)
   PUBMED   10359608
REFERENCE   10 (bases 1 to 4977)
  AUTHORS   Advani,R.J., Bae,H.R., Bock,J.B., Chao,D.S., Doung,Y.C.,
            Prekeris,R., Yoo,J.S. and Scheller,R.H.
  TITLE     Seven novel mammalian SNARE proteins localize to distinct membrane
            compartments
  JOURNAL   J Biol Chem 273 (17), 10317-10324 (1998)
   PUBMED   9553086
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DB167275.1, AL035296.1 and
            Z98751.1.
            
            On Nov 23, 2018 this sequence version replaced NM_003762.4.
            
            Summary: Synaptobrevins/VAMPs, syntaxins, and the 25-kD
            synaptosomal-associated protein SNAP25 are the main components of a
            protein complex involved in the docking and/or fusion of synaptic
            vesicles with the presynaptic membrane. The protein encoded by this
            gene is a member of the vesicle-associated membrane protein
            (VAMP)/synaptobrevin family. This protein may play a role in
            trans-Golgi network-to-endosome transport. [provided by RefSeq, Jul
            2008].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longer isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803613.517.1, SRR1660803.6601.1
                                           [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000236192.12/ ENSP00000236192.7
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-66                DB167275.1         175-240
            67-1223             AL035296.1         1-1157
            1224-4977           Z98751.1           31349-35102         c
FEATURES             Location/Qualifiers
     source          1..4977
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q24.3"
     gene            1..4977
                     /gene="VAMP4"
                     /gene_synonym="VAMP-4; VAMP24"
                     /note="vesicle associated membrane protein 4"
                     /db_xref="GeneID:8674"
                     /db_xref="HGNC:HGNC:12645"
                     /db_xref="MIM:606909"
     exon            1..156
                     /gene="VAMP4"
                     /gene_synonym="VAMP-4; VAMP24"
                     /inference="alignment:Splign:2.1.0"
     exon            157..271
                     /gene="VAMP4"
                     /gene_synonym="VAMP-4; VAMP24"
                     /inference="alignment:Splign:2.1.0"
     CDS             206..631
                     /gene="VAMP4"
                     /gene_synonym="VAMP-4; VAMP24"
                     /note="isoform 1 is encoded by transcript variant 1;
                     VAMP4/TAF3 fusion"
                     /codon_start=1
                     /product="vesicle-associated membrane protein 4 isoform 1"
                     /protein_id="NP_003753.2"
                     /db_xref="CCDS:CCDS1298.1"
                     /db_xref="GeneID:8674"
                     /db_xref="HGNC:HGNC:12645"
                     /db_xref="MIM:606909"
                     /translation="MPPKFKRHLNDDDVTGSVKSERRNLLEDDSDEEEDFFLRGPSGP
                     RFGPRNDKIKHVQNQVDEVIDVMQENITKVIERGERLDELQDKSESLSDNATAFSNRS
                     KQLRRQMWWRGCKIKAIMALVAAILLLVIIILIVMKYRT"
     exon            272..318
                     /gene="VAMP4"
                     /gene_synonym="VAMP-4; VAMP24"
                     /inference="alignment:Splign:2.1.0"
     exon            319..369
                     /gene="VAMP4"
                     /gene_synonym="VAMP-4; VAMP24"
                     /inference="alignment:Splign:2.1.0"
     exon            370..470
                     /gene="VAMP4"
                     /gene_synonym="VAMP-4; VAMP24"
                     /inference="alignment:Splign:2.1.0"
     exon            471..550
                     /gene="VAMP4"
                     /gene_synonym="VAMP-4; VAMP24"
                     /inference="alignment:Splign:2.1.0"
     exon            551..602
                     /gene="VAMP4"
                     /gene_synonym="VAMP-4; VAMP24"
                     /inference="alignment:Splign:2.1.0"
     exon            603..4977
                     /gene="VAMP4"
                     /gene_synonym="VAMP-4; VAMP24"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4951..4956
                     /regulatory_class="polyA_signal_sequence"
                     /gene="VAMP4"
                     /gene_synonym="VAMP-4; VAMP24"
                     /note="hexamer: AATAAA"
     polyA_site      4977
                     /gene="VAMP4"
                     /gene_synonym="VAMP-4; VAMP24"
                     /note="major polyA site"
ORIGIN      
        1 gatgagcgga ggcgctgctg cggcgctgcg gccgacgccg ggtccgcacc aactgtctcc
       61 ccctcccagc ttcttacctc ggcttcctac tccttccccc gcccgcccag caccgccagc
      121 ccgggagagc tgccgggagt tccccgggag cctcaggtgg tgactatcct gttgagaagc
      181 aaaagatact ttgcaagtaa aaaatatgcc tcccaagttt aagcgccacc tcaatgatga
      241 tgatgtcaca ggttctgtga aaagtgaaag gagaaatctt ttggaagatg attcagatga
      301 agaagaggac ttttttctaa ggggaccatc tggaccaaga tttggaccta gaaatgataa
      361 aattaagcat gttcagaatc aagtggatga agttattgat gtcatgcaag aaaatattac
      421 aaaggtaatt gagagagggg agagactaga tgaactacag gacaaatcag aaagcttatc
      481 ggataatgca acagctttta gcaacagatc caaacaactt cgaaggcaaa tgtggtggcg
      541 tggatgcaaa ataaaagcca tcatggcttt ggttgctgct atccttttgc tagtgattat
      601 cattcttata gtcatgaaat accgtacttg atttgatgac agagatcttc attaaacaag
      661 atctgggaca gtaataaaag attgctgcat aatttaaatg aaacctatgt gtatataact
      721 ttcaaaactt ctttttcaag aaactaagag gcaagtatca cttcaaattg gaacgttgag
      781 aatgtccaat tatcttctcc ctttctaaca aaatgttctt ttaataatta tgtttaaggc
      841 aaagagaact agcctctatt tttccatatt tcaaggatct aatttgaaac tagatacttg
      901 ccagttcatt atttgtgtat ataaacactg attataatat ttcatattaa tattttaatg
      961 gcataaggac ttgcattatt gcattaggga gcgggtcatg ctgggggtca ggaagcctgt
     1021 gtagagtacc aaattatatg ctgaaagaga tgcataacca ttctgtcaat atttgcagaa
     1081 atatagttcc tttcatatta cagttgtttt gcaagcaatt tccacattta taggtgtaac
     1141 aaaagctaaa tgttgtaaat gttgttgccc tcaggtataa ctaaaaacat tccagtaaat
     1201 atatttttga ctgtgtaaga gaatgtgtag taattttttt ggcattggat tatggaaatg
     1261 gaaattttta aacagtgtga aaaaacatgg tatggcatca taaaactgga gataataaag
     1321 ttattgaaga gtgtcattgg agtatttgaa aatgaccaat atatagctgc cagtcatggt
     1381 ccagtctgtt ttctgttaaa ctccaataaa gagagaccag tcagtcctaa tgtgagtaaa
     1441 tgaaatttac aggtaactta cttactcctt aattttattt tagttaatag cctctaactt
     1501 ccaactatct catttaccaa aagtacaaaa agtagcaaaa ccatctatta atactttgaa
     1561 ttttatatct ttgcatttcc tgttcatcct tgaggagatg tatgttgcac aatcaaattt
     1621 tgcatcagcc aacagtaatg agtagtagaa agtcaggaac ctatgtgtat atatatatat
     1681 atatatatat atatatatat atatatatat acacacaaac acacacacac acacacacac
     1741 acacgcacac atatgataat cagtcagtcg gtaaccaaat gctagagagt gaccattaac
     1801 ctaagcctgt ttttataatg aaaaaatgtg ttaactttaa aatatgccaa cctccttgtg
     1861 tcttttaaac aagtcagagt gaaaatacat tgtcccctaa ggtgtgggga gaggaagctt
     1921 tataataaaa ttagtgattc tgcagaaact tgtgcactgg atatcttgac aatatgaata
     1981 taaaactccc taaattaaaa atagggttaa tagaaattat cagtatttaa atagggaaaa
     2041 atgattttat gtttatttta tttaggtttt atttctttgg tcatcttaat gcaaaatgaa
     2101 taaagcatag aatctgggtt tggtgttttt ttgtctgttt ttaaaattct acaggattat
     2161 tactaggagg caaaaaatgc tgtttagaat ggaaaaaatt tgaagagaga aagcagactg
     2221 agacactcaa gacacctgca agttatctaa gaagatctaa atagaattac taaattttat
     2281 agtttgctta gagcatttag aaggagataa aggtcttaca tactatagtg tatattgtct
     2341 ttggtctcta tgctctttgt aaatgtcaat taatataaac agcatctgaa cagctaataa
     2401 atcttttaag ttaagatacc cagaaaaatg agcattttta gaatttcagt agctaataat
     2461 tcaggaatgg aaatatttta actgaatgga cagaatcagt cctaacattt gtatgtatgt
     2521 cctttatttg aattggaact aggctcataa gtggttaatt ttccattagt tgatgtagaa
     2581 atctggtttc tccataatat ctacaagtga agatgaagat tacttctcaa aaagtatcca
     2641 tatttccagt gttcctttta ataaaatatg ccacttttaa ataaataatt acaaaatgta
     2701 aaattataaa atttttaaat ttaaataata agtaacagta aaattttttg acaatatata
     2761 tgtcactgtc tttgtaattt aaacatattg ctgcctggga tatgggtaac agaattatca
     2821 ctcatggaac tttgtagtag tgatggcttg gtttgtaatt catcatttca tctttcttgg
     2881 tcttgattaa tcctgaaatc cttaaaatgg ctggcatggt tatgacttta ttgtggtaac
     2941 cttggagata taagccctct tacgatcaaa aacagaagaa aaaaatatat tgttcaaact
     3001 gatgccaggc ctacctttat tccctccctt aattactttt tttctcattc agctcagatc
     3061 atcctgcact tgaaaaatga agttttacca ccatcaaaac tatcattatt taacaacaag
     3121 tgaagatcaa cagaaaaatt caagtagctt tgcaaatact agttgatact cagtgaaatc
     3181 acgtcactat tttgatgcct gaatccatac ctttgtgatt tatgtttaat tacagaagcc
     3241 tattgccttg cagcaatttt gttgttataa tactgattaa ttggttactc cttcttatta
     3301 taactcagta atacctgtgg tcatttggtt cctctatcct gacaaagttc actggaaatt
     3361 gccctcagat tttataaact gggggatttc ttaattagat aaaagttcat tactgaagat
     3421 ggaatattat ataagatgga ggaagggtaa ttaatagaca tgagatatag aaatactttg
     3481 ttagccctgc tatagattgc ctattgtagt ctttctgtgc atttcaatag tctgtattag
     3541 gaaattataa cttcagcact tttgatagca aaaattggca tctttcaatt ctgtatagta
     3601 tgtgactatc ctgtaaatga taatatgtgt acagactgag aaggcaggaa tataaagtaa
     3661 ttgaaatctc tcattgccgg tatactctaa aacatgcttg atgccttgtc agcatcattg
     3721 cacacattga ctctgtattt acatctgtat atacactatg attagaaaat atgcaagaaa
     3781 ttgtttttcc atgttaagaa caaatgccat tagaagatgt ccccttaatt gtattgtcag
     3841 agtattacta tgtcaaggat gactgttctg ttaacctaat tttgtgtttt cacatggaaa
     3901 tgtgattgga ctccattttt ctgtgagttg agagtaagag cataagtcag tttgaaagca
     3961 tttacaagtt tgttttagaa tgtagtaagg gctgaaaggt gctctacttc ttaacttgtt
     4021 ttttccatgt tgtagacaaa tgaaatttgt ctaaatgctt ttgtctaaaa atgcatttgt
     4081 ctaaatgctt tagattgatg tagggtttag atcctcttta atactttgag atagtcttat
     4141 tctgattttt tttttcttct ggaaaccaag tagaattagg gatgggaata caaatgcatt
     4201 tattctggct tctgttttat tccaagaagc ttcttggaac aaatcagtag gaattgaaaa
     4261 gaaagcatga ccaacccaat tacaggggat aaatgtaagc ttgttaaagt aagcaccaca
     4321 ccatgtttct gtctccccag cacccagcac agtgctgtga accttggcag atgctagata
     4381 aatgtgtgtt gaatgaatgt gcctatgaag ccacaaagat gccacatgtt agtatatcag
     4441 tgagaggtga ctccacagtg ctctctggag aagcaatatg agtgactgaa gagtggggcc
     4501 ttttgctttt gcctggatat aggggtgctc ttctactgta attgggtgtg gaaaaactct
     4561 ggctttatgg tattccatta ggttcttttc atttaaagta gtcttaaaat caaagtatcc
     4621 aatattttaa agccacaaag tagattacat aattagcaga gattttagtc agtaaaatgt
     4681 tagaaatcaa actataagaa aattcaagtc ctttattttg tgtcttgggt atatgtcatt
     4741 attttaaatt ccacactccc ttatttaatc actttggtaa gtgcctttga tgttttgaaa
     4801 tgtatagtgg gagatgagca aatgtaaatg tcatgtgccc tgttccctag cttctcaatt
     4861 cctcataacc atttttacca gtgttgcaaa gtttagacct ttgtgttaat atcagaagtg
     4921 tatttgtagc ccctccatag tgaacaatga aataaactat ttcatagaaa acaaaaa
//
