LOCUS       NM_004781               2178 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens vesicle associated membrane protein 3 (VAMP3), mRNA.
ACCESSION   NM_004781
VERSION     NM_004781.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2178)
  AUTHORS   Zhao,Y., Yu,Y., Li,X. and Guo,A.
  TITLE     CCAAT enhancer binding protein delta activates vesicle associated
            membrane protein 3 transcription to enhance chemoresistance and
            extracellular PD-L1 expression in triple-negative breast cancer
  JOURNAL   J Exp Clin Cancer Res 43 (1), 115 (2024)
   PUBMED   38627816
  REMARK    GeneRIF: CCAAT enhancer binding protein delta activates vesicle
            associated membrane protein 3 transcription to enhance
            chemoresistance and extracellular PD-L1 expression in
            triple-negative breast cancer.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2178)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   3  (bases 1 to 2178)
  AUTHORS   Li,R., Jiang,Q. and Zheng,Y.
  TITLE     Circ_0002984 induces proliferation, migration and inflammation
            response of VSMCs induced by ox-LDL through miR-326-3p/VAMP3 axis
            in atherosclerosis
  JOURNAL   J Cell Mol Med 25 (16), 8028-8038 (2021)
   PUBMED   34169652
  REMARK    GeneRIF: Circ_0002984 induces proliferation, migration and
            inflammation response of VSMCs induced by ox-LDL through
            miR-326-3p/VAMP3 axis in atherosclerosis.
REFERENCE   4  (bases 1 to 2178)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   5  (bases 1 to 2178)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   6  (bases 1 to 2178)
  AUTHORS   Prekeris,R., Klumperman,J., Chen,Y.A. and Scheller,R.H.
  TITLE     Syntaxin 13 mediates cycling of plasma membrane proteins via
            tubulovesicular recycling endosomes
  JOURNAL   J Cell Biol 143 (4), 957-971 (1998)
   PUBMED   9817754
REFERENCE   7  (bases 1 to 2178)
  AUTHORS   Riento,K., Galli,T., Jansson,S., Ehnholm,C., Lehtonen,E. and
            Olkkonen,V.M.
  TITLE     Interaction of Munc-18-2 with syntaxin 3 controls the association
            of apical SNAREs in epithelial cells
  JOURNAL   J Cell Sci 111 (Pt 17), 2681-2688 (1998)
   PUBMED   9701566
REFERENCE   8  (bases 1 to 2178)
  AUTHORS   Galli,T., Zahraoui,A., Vaidyanathan,V.V., Raposo,G., Tian,J.M.,
            Karin,M., Niemann,H. and Louvard,D.
  TITLE     A novel tetanus neurotoxin-insensitive vesicle-associated membrane
            protein in SNARE complexes of the apical plasma membrane of
            epithelial cells
  JOURNAL   Mol Biol Cell 9 (6), 1437-1448 (1998)
   PUBMED   9614185
REFERENCE   9  (bases 1 to 2178)
  AUTHORS   Annaert,W.G., Becker,B., Kistner,U., Reth,M. and Jahn,R.
  TITLE     Export of cellubrevin from the endoplasmic reticulum is controlled
            by BAP31
  JOURNAL   J Cell Biol 139 (6), 1397-1410 (1997)
   PUBMED   9396746
REFERENCE   10 (bases 1 to 2178)
  AUTHORS   Timmers,K.I., Clark,A.E., Omatsu-Kanbe,M., Whiteheart,S.W.,
            Bennett,M.K., Holman,G.D. and Cushman,S.W.
  TITLE     Identification of SNAP receptors in rat adipose cell membrane
            fractions and in SNARE complexes co-immunoprecipitated with
            epitope-tagged N-ethylmaleimide-sensitive fusion protein
  JOURNAL   Biochem J 320 (Pt 2) (Pt 2), 429-436 (1996)
   PUBMED   8973549
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC005941.1 and BC003570.1.
            
            On Nov 23, 2018 this sequence version replaced NM_004781.3.
            
            Summary: Synaptobrevins/VAMPs, syntaxins, and the 25-kD
            synaptosomal-associated protein are the main components of a
            protein complex involved in the docking and/or fusion of synaptic
            vesicles with the presynaptic membrane. This gene is a member of
            the vesicle-associated membrane protein (VAMP)/synaptobrevin
            family. Because of its high homology to other known VAMPs, its
            broad tissue distribution, and its subcellular localization, the
            protein encoded by this gene was shown to be the human equivalent
            of the rodent cellubrevin. In platelets the protein resides on a
            compartment that is not mobilized to the plasma membrane on calcium
            or thrombin stimulation. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.201507.1,
                                           SRR3476690.404792.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000054666.11/ ENSP00000054666.6
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-64                BC005941.1         28-91
            65-2178             BC003570.1         12-2125
FEATURES             Location/Qualifiers
     source          1..2178
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p36.23"
     gene            1..2178
                     /gene="VAMP3"
                     /gene_synonym="CEB"
                     /note="vesicle associated membrane protein 3"
                     /db_xref="GeneID:9341"
                     /db_xref="HGNC:HGNC:12644"
                     /db_xref="MIM:603657"
     exon            1..90
                     /gene="VAMP3"
                     /gene_synonym="CEB"
                     /inference="alignment:Splign:2.1.0"
     CDS             89..391
                     /gene="VAMP3"
                     /gene_synonym="CEB"
                     /note="cellubrevin; synaptobrevin-3"
                     /codon_start=1
                     /product="vesicle-associated membrane protein 3"
                     /protein_id="NP_004772.1"
                     /db_xref="CCDS:CCDS88.1"
                     /db_xref="GeneID:9341"
                     /db_xref="HGNC:HGNC:12644"
                     /db_xref="MIM:603657"
                     /translation="MSTGPTAATGSNRRLQQTQNQVDEVVDIMRVNVDKVLERDQKLS
                     ELDDRADALQAGASQFETSAAKLKRKYWWKNCKMWAIGITVLVIFIIIIIVWVVSS"
     exon            91..160
                     /gene="VAMP3"
                     /gene_synonym="CEB"
                     /inference="alignment:Splign:2.1.0"
     exon            161..319
                     /gene="VAMP3"
                     /gene_synonym="CEB"
                     /inference="alignment:Splign:2.1.0"
     exon            320..371
                     /gene="VAMP3"
                     /gene_synonym="CEB"
                     /inference="alignment:Splign:2.1.0"
     exon            372..2178
                     /gene="VAMP3"
                     /gene_synonym="CEB"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2157..2162
                     /regulatory_class="polyA_signal_sequence"
                     /gene="VAMP3"
                     /gene_synonym="CEB"
                     /note="hexamer: AATAAA"
     polyA_site      2178
                     /gene="VAMP3"
                     /gene_synonym="CEB"
                     /note="major polyA site"
ORIGIN      
        1 gtcccaccca tctccctggc ctccggtccc aacttcgctt ctctgctgac cctctctcgt
       61 cgccgctgcc gccgccgcag ctgccaaaat gtctacaggt ccaactgctg ccactggcag
      121 taatcgaaga cttcagcaga cacaaaatca agtagatgag gtggtggaca taatgcgagt
      181 taacgtggac aaggttctgg aaagagacca gaagctctct gagttagacg accgtgcaga
      241 cgcactgcag gcaggcgctt ctcaatttga aacgagcgca gccaagttga agaggaaata
      301 ttggtggaag aattgcaaga tgtgggcaat cgggattact gttctggtta tcttcatcat
      361 catcatcatc gtgtgggttg tctcttcatg aagaaccagc ggaactcaaa actgctgttc
      421 aagaaacctc ttcaagactt ttgacttaga acctgctata ttatcaagct tacctactgt
      481 tatctctaaa attttttttg tgttaatgta aagttgaatt tctaggaaac gtgcctttgt
      541 tttttaatat gcactccaaa ttagaaggcc ggccccgtcc acattttgca cagtgccttt
      601 acagatttac gtatgggctg atgaagaggc cttcttaagt tccagagtgc tataatctag
      661 atgtaatgtt gtcactaatt aattgccatt actcccagtt agttaccctt gtcatttggc
      721 attattttca gaaccacatt ttaaaccttt gggtaatcag atttccaact tatgccttcc
      781 agaaaaaaac actactgcct aacacaaatc tgtgataaca acaggctgtg ccttattttg
      841 ataattttct gattccctag aagagaaccc tctacttttt gtaagcacta ctgactctcg
      901 ctgtatttaa gatgctggtg aagagctttt gctcttgcat tagatttgaa gatgtttaca
      961 ttgttgttat tgttatgtat cacttgctaa aaatattgtt ttaatcagag ataacctctt
     1021 taaaaaaatt tttaaagaac tatggctatg accaaagctt ctattttgcc aaaaagttaa
     1081 ataccgataa aatggcctta agtgtattcc tgacagttaa attcagaaac gtgccaaatg
     1141 gaactcaagg tgccccttca gaattaaaat cattaccttg tgtgtgaacc ttctacatct
     1201 tcataggcct ttcttccttt tgaaaggctg tagacagtgt ggctcccctt ctgattcagt
     1261 attttgcatg ggggttagag aaggtttgag gtagactctg accgtctcat aaaagagttc
     1321 tacccagcag ttggcagatt atcagctgtg gactccagca tgtttctgat aattatgcaa
     1381 gcaacaattc tgtagcctca agtaagacca cctgtgaact tgatcattat ctggcccaaa
     1441 tatgaagata aactataact ttggagtttg tttcctattt gtattcacat tctgcttcct
     1501 aaatcagttt tctaaattat gcctgcaatt aggcattggt caggggtgaa tggctctttt
     1561 cacagagagt agccaaccag agacctttgc tttgatatca tcaactgcag agaatgctgt
     1621 tgatgggaat gctggaagca gaaactttgt catcggaaaa acttttcttg tatgcatgag
     1681 actcaacatc aggatccaca gcttaaagat gggaattcag gtatgaaaga aaacaggcaa
     1741 ggaggcactg agggagaaag acacagactt tatcgctctg tggctcattg ttactggaat
     1801 attctaaaac tcttgttcac atgctattat gacttataaa gcagcaacag ctgaggcgca
     1861 ccaggacaca gcttccattt ctttaacgtc tgttccctta acatcgctga aatgatttac
     1921 tgttgaagag atgccttgcg gtgtggccag ctgtgaggag aaagcagctg gcagtgttag
     1981 gacattagtc caccttcagc gcagggtctc tggccgggtc tgactcagaa accttggtac
     2041 tcgccccttg gccacagtgc ccagacccat gtaacccact ggctcctgca ttaacccaga
     2101 aatacctcgc ttctatctgt gcacttagct gggaacttac ccactgtaat cacctaaata
     2161 aagtgtttat aaacatga
//
