LOCUS       NM_004182                595 bp    mRNA    linear   PRI 21-SEP-2024
DEFINITION  Homo sapiens ubiquitously expressed prefoldin like chaperone (UXT),
            transcript variant 2, mRNA.
ACCESSION   NM_004182
VERSION     NM_004182.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 595)
  AUTHORS   Peng,W., Zeng,C., Xu,J., Zhao,H., Zhu,Q., Xu,H., Chen,H., Huang,H.,
            Zhou,Y. and Zhao,C.
  TITLE     Regulation of epithelial cell differentiation by the Ubiquitous
            expressed transcript isoform 1 in ulcerative colitis
  JOURNAL   J Gastroenterol Hepatol 38 (11), 2006-2017 (2023)
   PUBMED   37608570
REFERENCE   2  (bases 1 to 595)
  AUTHORS   Lemma,R.B., Ledsaak,M., Fuglerud,B.M., Rodriguez-Castaneda,F.,
            Eskeland,R. and Gabrielsen,O.S.
  TITLE     MYB regulates the SUMO protease SENP1 and its novel interaction
            partner UXT, modulating MYB target genes and the SUMO landscape
  JOURNAL   J Biol Chem 299 (9), 105062 (2023)
   PUBMED   37468105
  REMARK    GeneRIF: MYB regulates the SUMO protease SENP1 and its novel
            interaction partner UXT, modulating MYB target genes and the SUMO
            landscape.
REFERENCE   3  (bases 1 to 595)
  AUTHORS   Zhao,H., Chen,C., Yang,C., Mo,S., Zhao,H. and Tian,Y.
  TITLE     Prefoldin and prefoldin-like complex subunits as predictive
            biomarkers for hepatocellular carcinoma immunotherapy
  JOURNAL   Pathol Res Pract 232, 153808 (2022)
   PUBMED   35217267
  REMARK    GeneRIF: Prefoldin and prefoldin-like complex subunits as
            predictive biomarkers for hepatocellular carcinoma immunotherapy.
REFERENCE   4  (bases 1 to 595)
  AUTHORS   Hu,X.C., Chu,J., Zhou,Y., Li,C.C., Zhou,G.J. and Jiang,G.Q.
  TITLE     HOXD9 transcriptionally induced UXT facilitate breast cancer
            progression via epigenetic modification of RND3
  JOURNAL   Cell Signal 90, 110188 (2022)
   PUBMED   34767964
  REMARK    GeneRIF: HOXD9 transcriptionally induced UXT facilitate breast
            cancer progression via epigenetic modification of RND3.
REFERENCE   5  (bases 1 to 595)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   6  (bases 1 to 595)
  AUTHORS   Liu,L., Amy,V., Liu,G. and McKeehan,W.L.
  TITLE     Novel complex integrating mitochondria and the microtubular
            cytoskeleton with chromosome remodeling and tumor suppressor RASSF1
            deduced by in silico homology analysis, interaction cloning in
            yeast, and colocalization in cultured cells
  JOURNAL   In Vitro Cell Dev Biol Anim 38 (10), 582-594 (2002)
   PUBMED   12762840
REFERENCE   7  (bases 1 to 595)
  AUTHORS   Thiselton,D.L., McDowall,J., Brandau,O., Ramser,J., d'Esposito,F.,
            Bhattacharya,S.S., Ross,M.T., Hardcastle,A.J. and Meindl,A.
  TITLE     An integrated, functionally annotated gene map of the DXS8026-ELK1
            interval on human Xp11.3-Xp11.23: potential hotspot for
            neurogenetic disorders
  JOURNAL   Genomics 79 (4), 560-572 (2002)
   PUBMED   11944989
  REMARK    Erratum:[Genomics 2002 Jun;79(6):891]
REFERENCE   8  (bases 1 to 595)
  AUTHORS   Markus,S.M., Taneja,S.S., Logan,S.K., Li,W., Ha,S., Hittelman,A.B.,
            Rogatsky,I. and Garabedian,M.J.
  TITLE     Identification and characterization of ART-27, a novel coactivator
            for the androgen receptor N terminus
  JOURNAL   Mol Biol Cell 13 (2), 670-682 (2002)
   PUBMED   11854421
  REMARK    GeneRIF: UXT was identified in a screen for proteins that interact
            with the Androgen Receptor N-terminal activation domain.  We termed
            the protein Androgen Receptor Trapped clone 27 (ART-27).  ART-27
            appears to function as a transcriptional coactivator protein.
REFERENCE   9  (bases 1 to 595)
  AUTHORS   Liu,L. and McKeehan,W.L.
  TITLE     Sequence analysis of LRPPRC and its SEC1 domain interaction
            partners suggests roles in cytoskeletal organization, vesicular
            trafficking, nucleocytosolic shuttling, and chromosome activity
  JOURNAL   Genomics 79 (1), 124-136 (2002)
   PUBMED   11827465
REFERENCE   10 (bases 1 to 595)
  AUTHORS   Schroer,A., Schneider,S., Ropers,H. and Nothwang,H.
  TITLE     Cloning and characterization of UXT, a novel gene in human Xp11,
            which is widely and abundantly expressed in tumor tissue
  JOURNAL   Genomics 56 (3), 340-343 (1999)
   PUBMED   10087202
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA372561.1, AF092737.1 and
            BQ681820.1.
            
            On Aug 13, 2020 this sequence version replaced NM_004182.3.
            
            Summary: The protein encoded by this gene functions as a cofactor
            that modulates androgen receptor-dependent transcription, and also
            plays a critical role in tumor necrosis factor-induced apoptosis.
            Expression of this gene may play a role in tumorigenesis.
            Alternatively spliced transcript variants encoding multiple
            isoforms have been observed for this gene. [provided by RefSeq, Nov
            2011].
            
            Transcript Variant: This variant (2) differs in the 5' UTR and
            initiates translation at a downstream, in-frame start codon,
            compared to variant 1. The encoded isoform (2) has a shorter
            N-terminus, compared to isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BQ676558.1, CR736741.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000333119.8/ ENSP00000327797.3
            RefSeq Select criteria :: based on manual assertion, conservation
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-19                DA372561.1         1-19
            20-593              AF092737.1         1-574
            594-595             BQ681820.1         268-269
FEATURES             Location/Qualifiers
     source          1..595
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /map="Xp11.23"
     gene            1..595
                     /gene="UXT"
                     /gene_synonym="ART-27; SKP2; STAP1"
                     /note="ubiquitously expressed prefoldin like chaperone"
                     /db_xref="GeneID:8409"
                     /db_xref="HGNC:HGNC:12641"
                     /db_xref="MIM:300234"
     exon            1..66
                     /gene="UXT"
                     /gene_synonym="ART-27; SKP2; STAP1"
                     /inference="alignment:Splign:2.1.0"
     exon            67..173
                     /gene="UXT"
                     /gene_synonym="ART-27; SKP2; STAP1"
                     /inference="alignment:Splign:2.1.0"
     CDS             76..549
                     /gene="UXT"
                     /gene_synonym="ART-27; SKP2; STAP1"
                     /note="isoform 2 is encoded by transcript variant 2;
                     protein UXT; SKP2-associated alpha PFD 1; ubiquitously
                     expressed transcript protein; androgen receptor trapped
                     clone 27 protein"
                     /codon_start=1
                     /product="protein UXT isoform 2"
                     /protein_id="NP_004173.1"
                     /db_xref="CCDS:CCDS14285.1"
                     /db_xref="GeneID:8409"
                     /db_xref="HGNC:HGNC:12641"
                     /db_xref="MIM:300234"
                     /translation="MATPPKRRAVEATGEKVLRYETFISDVLQRDLRKVLDHRDKVYE
                     QLAKYLQLRNVIERLQEAKHSELYMQVDLGCNFFVDTVVPDTSRIYVALGYGFFLELT
                     LAEALKFIDRKSSLLTELSNSLTKDSMNIKAHIHMLLEGLRELQGLQNFPEKPHH"
     exon            174..255
                     /gene="UXT"
                     /gene_synonym="ART-27; SKP2; STAP1"
                     /inference="alignment:Splign:2.1.0"
     exon            256..323
                     /gene="UXT"
                     /gene_synonym="ART-27; SKP2; STAP1"
                     /inference="alignment:Splign:2.1.0"
     exon            324..431
                     /gene="UXT"
                     /gene_synonym="ART-27; SKP2; STAP1"
                     /inference="alignment:Splign:2.1.0"
     exon            432..495
                     /gene="UXT"
                     /gene_synonym="ART-27; SKP2; STAP1"
                     /inference="alignment:Splign:2.1.0"
     exon            496..595
                     /gene="UXT"
                     /gene_synonym="ART-27; SKP2; STAP1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      572..577
                     /regulatory_class="polyA_signal_sequence"
                     /gene="UXT"
                     /gene_synonym="ART-27; SKP2; STAP1"
                     /note="hexamer: ATTAAA"
     polyA_site      595
                     /gene="UXT"
                     /gene_synonym="ART-27; SKP2; STAP1"
                     /note="major polyA site"
ORIGIN      
        1 gtcattcacc cgcgccaccc ggaagccgcg gttcctacca accgttctta ttgctggcgg
       61 cctgaggagc ccatcatggc gacgccccct aagcggcggg cggtggaggc cacgggggag
      121 aaagtgctgc gctacgagac cttcatcagt gacgtgctgc agcgggactt gcgaaaggtg
      181 ctggaccatc gagacaaggt atatgagcag ctggccaaat accttcaact gagaaatgtc
      241 attgagcgac tccaggaagc taagcactcg gagttatata tgcaggtgga tttgggctgt
      301 aacttcttcg ttgacacagt ggtcccagat acttcacgca tctatgtggc cctgggatat
      361 ggttttttcc tggagttgac actggcagaa gctctcaagt tcattgatcg taagagctct
      421 ctcctcacag agctcagcaa cagcctcacc aaggactcca tgaatatcaa agcccatatc
      481 cacatgttgc tagaggggct tagagaacta caaggcctgc agaatttccc agagaagcct
      541 caccattgac ttcttccccc catcctcaga cattaaagag cctgaatgcc tttga
//
