LOCUS       NM_001377506            2398 bp    mRNA    linear   PRI 07-APR-2024
DEFINITION  Homo sapiens UDP-glucuronate decarboxylase 1 (UXS1), transcript
            variant 7, mRNA.
ACCESSION   NM_001377506 XM_011511904
VERSION     NM_001377506.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2398)
  AUTHORS   Brewer,G.
  TITLE     UXS1: a sweet spot for cell death
  JOURNAL   Nat Rev Cancer 24 (1), 3 (2024)
   PUBMED   38030856
  REMARK    GeneRIF: UXS1: a sweet spot for cell death.
REFERENCE   2  (bases 1 to 2398)
  AUTHORS   Walsh,R.M. Jr., Polizzi,S.J., Kadirvelraj,R., Howard,W.W. and
            Wood,Z.A.
  TITLE     Man o' war mutation in UDP-alpha-D-xylose synthase favors the
            abortive catalytic cycle and uncovers a latent potential for
            hexamer formation
  JOURNAL   Biochemistry 54 (3), 807-819 (2015)
   PUBMED   25521717
  REMARK    GeneRIF: The persistence of a latent hexamer-building interface in
            the human enzyme suggests that the ancestral UXS may have been a
            hexamer.
REFERENCE   3  (bases 1 to 2398)
  AUTHORS   Polizzi,S.J., Walsh,R.M. Jr., Le Magueres,P., Criswell,A.R. and
            Wood,Z.A.
  TITLE     Human UDP-alpha-d-xylose synthase forms a catalytically important
            tetramer that has not been observed in crystal structures
  JOURNAL   Biochemistry 52 (22), 3888-3898 (2013)
   PUBMED   23656592
  REMARK    GeneRIF: hUXS forms a tetramer in solution that is important for
            activity. The higher activity of the tetramer coupled with the
            relative instability of the dimeric complex suggests that an
            association-dissociation mechanism may regulate hUXS activity.
REFERENCE   4  (bases 1 to 2398)
  AUTHORS   Polizzi,S.J., Walsh,R.M. Jr., Peeples,W.B., Lim,J.M., Wells,L. and
            Wood,Z.A.
  TITLE     Human UDP-alpha-D-xylose synthase and Escherichia coli ArnA
            conserve a conformational shunt that controls whether xylose or
            4-keto-xylose is produced
  JOURNAL   Biochemistry 51 (44), 8844-8855 (2012)
   PUBMED   23072385
REFERENCE   5  (bases 1 to 2398)
  AUTHORS   Eixelsberger,T., Sykora,S., Egger,S., Brunsteiner,M.,
            Kavanagh,K.L., Oppermann,U., Brecker,L. and Nidetzky,B.
  TITLE     Structure and mechanism of human UDP-xylose synthase: evidence for
            a promoting role of sugar ring distortion in a three-step catalytic
            conversion of UDP-glucuronic acid
  JOURNAL   J Biol Chem 287 (37), 31349-31358 (2012)
   PUBMED   22810237
REFERENCE   6  (bases 1 to 2398)
  AUTHORS   Persson,B., Kallberg,Y., Bray,J.E., Bruford,E., Dellaporta,S.L.,
            Favia,A.D., Duarte,R.G., Jornvall,H., Kavanagh,K.L., Kedishvili,N.,
            Kisiela,M., Maser,E., Mindnich,R., Orchard,S., Penning,T.M.,
            Thornton,J.M., Adamski,J. and Oppermann,U.
  TITLE     The SDR (short-chain dehydrogenase/reductase and related enzymes)
            nomenclature initiative
  JOURNAL   Chem Biol Interact 178 (1-3), 94-98 (2009)
   PUBMED   19027726
REFERENCE   7  (bases 1 to 2398)
  AUTHORS   Gonzalez-Begne,M., Lu,B., Han,X., Hagen,F.K., Hand,A.R.,
            Melvin,J.E. and Yates,J.R.
  TITLE     Proteomic analysis of human parotid gland exosomes by
            multidimensional protein identification technology (MudPIT)
  JOURNAL   J Proteome Res 8 (3), 1304-1314 (2009)
   PUBMED   19199708
REFERENCE   8  (bases 1 to 2398)
  AUTHORS   Bakker,H., Oka,T., Ashikov,A., Yadav,A., Berger,M., Rana,N.A.,
            Bai,X., Jigami,Y., Haltiwanger,R.S., Esko,J.D. and
            Gerardy-Schahn,R.
  TITLE     Functional UDP-xylose transport across the endoplasmic
            reticulum/Golgi membrane in a Chinese hamster ovary cell mutant
            defective in UDP-xylose Synthase
  JOURNAL   J Biol Chem 284 (4), 2576-2583 (2009)
   PUBMED   19028698
  REMARK    GeneRIF: Complementation was achieved by expression of a
            cytoplasmic variant of UDP-xylose Synthase, which proves the
            existence of a functional Golgi UDP-xylose transporter[UDP-xylose
            Synthase]
REFERENCE   9  (bases 1 to 2398)
  AUTHORS   Hwang,H.Y. and Horvitz,H.R.
  TITLE     The SQV-1 UDP-glucuronic acid decarboxylase and the SQV-7
            nucleotide-sugar transporter may act in the Golgi apparatus to
            affect Caenorhabditis elegans vulval morphogenesis and embryonic
            development
  JOURNAL   Proc Natl Acad Sci U S A 99 (22), 14218-14223 (2002)
   PUBMED   12391314
REFERENCE   10 (bases 1 to 2398)
  AUTHORS   Moriarity,J.L., Hurt,K.J., Resnick,A.C., Storm,P.B., Laroy,W.,
            Schnaar,R.L. and Snyder,S.H.
  TITLE     UDP-glucuronate decarboxylase, a key enzyme in proteoglycan
            synthesis: cloning, characterization, and localization
  JOURNAL   J Biol Chem 277 (19), 16968-16975 (2002)
   PUBMED   11877387
  REMARK    GeneRIF: UDP-glucuronate decarboxylase, a key enzyme in
            proteoglycan synthesis: cloning, characterization, and
            localization.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC018878.8.
            
            On Jan 16, 2020 this sequence version replaced XM_011511904.3.
            
            Summary: This gene encodes an enzyme found in the perinuclear Golgi
            which catalyzes the synthesis of UDP-xylose used in
            glycosaminoglycan (GAG) synthesis on proteoglycans. The GAG chains
            are covalently attached to proteoglycans which participate in
            signaling pathways during development. Multiple transcript variants
            encoding different isoforms have been found for this gene.
            [provided by RefSeq, Dec 2014].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038193.3893950.1,
                                           SRR14038195.1392766.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-635               AC018878.8         130787-131421       c
            636-696             AC018878.8         128842-128902       c
            697-877             AC018878.8         115974-116154       c
            878-982             AC018878.8         100458-100562       c
            983-1042            AC018878.8         96404-96463         c
            1043-1164           AC018878.8         93754-93875         c
            1165-1284           AC018878.8         83430-83549         c
            1285-1328           AC018878.8         75578-75621         c
            1329-1389           AC018878.8         71842-71902         c
            1390-1447           AC018878.8         69500-69557         c
            1448-1551           AC018878.8         67502-67605         c
            1552-2398           AC018878.8         64095-64941         c
FEATURES             Location/Qualifiers
     source          1..2398
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2q12.2"
     gene            1..2398
                     /gene="UXS1"
                     /gene_synonym="hUXS; hUXS1; SDR6E1; UGD"
                     /note="UDP-glucuronate decarboxylase 1"
                     /db_xref="GeneID:80146"
                     /db_xref="HGNC:HGNC:17729"
                     /db_xref="MIM:609749"
     exon            1..635
                     /gene="UXS1"
                     /gene_synonym="hUXS; hUXS1; SDR6E1; UGD"
                     /inference="alignment:Splign:2.1.0"
     CDS             586..1683
                     /gene="UXS1"
                     /gene_synonym="hUXS; hUXS1; SDR6E1; UGD"
                     /EC_number="4.1.1.35"
                     /note="isoform 6 is encoded by transcript variant 7; short
                     chain dehydrogenase/reductase family 6E, member 12;
                     UDP-glucuronic acid decarboxylase 1; UXS-1"
                     /codon_start=1
                     /product="UDP-glucuronic acid decarboxylase 1 isoform 6"
                     /protein_id="NP_001364435.1"
                     /db_xref="GeneID:80146"
                     /db_xref="HGNC:HGNC:17729"
                     /db_xref="MIM:609749"
                     /translation="MTFLRHFLWAASTKDGRFTQKYPPVKFLSEKDRKRILITGGAGF
                     VGSHLTDKLMMDGHEVTVVDNFFTGRKRNVEHWIGHENFELINHDVVEPLYIEVDQIY
                     HLASPASPPNYMYNPIKTLKTNTIGTLNMLGLAKRVGARLLLASTSEVYGDPEVHPQS
                     EDYWGHVNPIGPRACYDEGKRVAETMCYAYMKQEGVEVRVARIFNTFGPRMHMNDGRV
                     VSNFILQALQGEPLTVYGSGSQTRAFQYVSDLVNGLVALMNSNVSSPVNLGNPEEHTI
                     LEFAQLIKNLVGSGSEIQFLSEAQDDPQKRKPDIKKAKLMLGWEPVVPLEEGLNKAIH
                     YFRKELEYQANNQYIPKPKPARIKKGRTRHS"
     exon            636..696
                     /gene="UXS1"
                     /gene_synonym="hUXS; hUXS1; SDR6E1; UGD"
                     /inference="alignment:Splign:2.1.0"
     exon            697..877
                     /gene="UXS1"
                     /gene_synonym="hUXS; hUXS1; SDR6E1; UGD"
                     /inference="alignment:Splign:2.1.0"
     exon            878..982
                     /gene="UXS1"
                     /gene_synonym="hUXS; hUXS1; SDR6E1; UGD"
                     /inference="alignment:Splign:2.1.0"
     exon            983..1042
                     /gene="UXS1"
                     /gene_synonym="hUXS; hUXS1; SDR6E1; UGD"
                     /inference="alignment:Splign:2.1.0"
     exon            1043..1164
                     /gene="UXS1"
                     /gene_synonym="hUXS; hUXS1; SDR6E1; UGD"
                     /inference="alignment:Splign:2.1.0"
     exon            1165..1284
                     /gene="UXS1"
                     /gene_synonym="hUXS; hUXS1; SDR6E1; UGD"
                     /inference="alignment:Splign:2.1.0"
     exon            1285..1328
                     /gene="UXS1"
                     /gene_synonym="hUXS; hUXS1; SDR6E1; UGD"
                     /inference="alignment:Splign:2.1.0"
     exon            1329..1389
                     /gene="UXS1"
                     /gene_synonym="hUXS; hUXS1; SDR6E1; UGD"
                     /inference="alignment:Splign:2.1.0"
     exon            1390..1447
                     /gene="UXS1"
                     /gene_synonym="hUXS; hUXS1; SDR6E1; UGD"
                     /inference="alignment:Splign:2.1.0"
     exon            1448..1551
                     /gene="UXS1"
                     /gene_synonym="hUXS; hUXS1; SDR6E1; UGD"
                     /inference="alignment:Splign:2.1.0"
     exon            1552..2398
                     /gene="UXS1"
                     /gene_synonym="hUXS; hUXS1; SDR6E1; UGD"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2377..2382
                     /regulatory_class="polyA_signal_sequence"
                     /gene="UXS1"
                     /gene_synonym="hUXS; hUXS1; SDR6E1; UGD"
                     /note="hexamer: AATAAA"
     polyA_site      2398
                     /gene="UXS1"
                     /gene_synonym="hUXS; hUXS1; SDR6E1; UGD"
                     /note="major polyA site"
ORIGIN      
        1 agatagggac tattctaagc tgacagcttg gattaacatt tgtttccatg gccccggatg
       61 cacactccac agtcctgcgc ctccgctcct cactgaattg gttttctccc tgcaccgcgt
      121 tttcccatat gtagctatat tcccattccc gagcggtctt gactctaaaa tcatatacac
      181 ggtagagaag gagccctgaa ggtgagtgag gggaagtcat gagtcagaga cggctccagc
      241 gttttcacga cagacagttc ggaggagcca cggtgcttat gagcagtcgt gggaaggaaa
      301 gagtctcagc tgtgccacgg cactgggtgt gccacttggg gactgaggct gaagacatgg
      361 atatcgtgag ctcagagaaa tgaggacaat tggagcggtg tgagaggtgc acacaaataa
      421 ctctgagatt tacagtgccg tcccctagct gagttggtga gggaagaaga ggcggaatga
      481 caagaagtgt tacttggcaa acaagacatc tgtgccgctc ccgccagtct aacagcatcg
      541 ctcctgactg aaggcagaac ttgctcctgc tccccagctg catggatgac tttcctgagg
      601 cacttcctat gggcggcaag tactaaagac ggtcgcttta cccagaaata cccaccagta
      661 aagtttttat cagaaaagga tcggaaaaga attttgataa caggaggcgc agggttcgtg
      721 ggctcccatc taactgacaa actcatgatg gacggccacg aggtgaccgt ggtggacaat
      781 ttcttcacgg gcaggaagag aaacgtggag cactggatcg gacatgagaa cttcgagttg
      841 attaaccacg acgtggtgga gcccctctac atcgaggttg accagatata ccatctggca
      901 tctccagcct cccctccaaa ctacatgtat aatcctatca agacattaaa gaccaatacg
      961 attgggacat taaacatgtt ggggctggca aaacgagtcg gtgcccgtct gctcctggcc
     1021 tccacatcgg aggtgtatgg agatcctgaa gtccaccctc aaagtgagga ttactggggc
     1081 cacgtgaatc caataggacc tcgggcctgc tacgatgaag gcaaacgtgt tgcagagacc
     1141 atgtgctatg cctacatgaa gcaggaaggc gtggaagtgc gagtggccag aatcttcaac
     1201 acctttgggc cacgcatgca catgaacgat gggcgagtag tcagcaactt catcctgcag
     1261 gcgctccagg gggagccact cacggtatac ggatccgggt ctcagacaag ggcgttccag
     1321 tacgtcagcg atctagtgaa tggcctcgtg gctctcatga acagcaacgt cagcagcccg
     1381 gtcaacctgg ggaacccaga agaacacaca atcctagaat ttgctcagtt aattaaaaac
     1441 cttgttggta gcggaagtga aattcagttt ctctccgaag cccaggatga cccacagaaa
     1501 agaaaaccag acatcaaaaa agcaaagctg atgctggggt gggagcccgt ggtcccgctg
     1561 gaggaaggtt taaacaaagc aattcactac ttccgtaaag aactcgagta ccaggcaaat
     1621 aatcagtaca tccccaaacc aaagcctgcc agaataaaga aaggacggac tcgccacagc
     1681 tgaactcctc acttttagga cacaagacta ccattgtaca cttgatggga tgtatttttg
     1741 gctttttttt gttgtcgttt aaagaaagac tttaacaggt gtcatgaaga acaaactgga
     1801 atttcattct gaagcttgct ttaatgaaat ggatgtgcct aaaagctccc ctcaaaaaac
     1861 tgcagatttt gccttgcact ttttgaatct ctctttttat gtaaaatagc gtagatgcat
     1921 ctctgcgtat tttcaagttt ttttatcttg ctgtgagagc atatgttgtg actgtcgttg
     1981 acagttttat ttactggttt ctttgtgaag ctgaaaagga acattaagcg ggacaaaaaa
     2041 tgccgatttt atttatgaaa gtgggtactt aataaatgag tcgttatact atgcataaag
     2101 aaaaatccta gcagtattgt caggtggtgg tgcgccggca ttgattttag ggcagataaa
     2161 agaattctgt gtgagagctt tatgtttctc ttttaattca gagtttttcc aaggtctact
     2221 tttgagttgc aaacttgact ttgaaatatt cctgttggtc atgatcaagg atatttgaaa
     2281 tcactactgt gttttgctgc gtatctgggg cgggggcagg ttggggggca caaagttaac
     2341 atattcttgg ttaaccatgg ttaaatatgc tattttaata aattattgaa actcacca
//
