LOCUS       NM_001377505            1876 bp    mRNA    linear   PRI 07-APR-2024
DEFINITION  Homo sapiens UDP-glucuronate decarboxylase 1 (UXS1), transcript
            variant 6, mRNA.
ACCESSION   NM_001377505 XM_017005009
VERSION     NM_001377505.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1876)
  AUTHORS   Brewer,G.
  TITLE     UXS1: a sweet spot for cell death
  JOURNAL   Nat Rev Cancer 24 (1), 3 (2024)
   PUBMED   38030856
  REMARK    GeneRIF: UXS1: a sweet spot for cell death.
REFERENCE   2  (bases 1 to 1876)
  AUTHORS   Walsh,R.M. Jr., Polizzi,S.J., Kadirvelraj,R., Howard,W.W. and
            Wood,Z.A.
  TITLE     Man o' war mutation in UDP-alpha-D-xylose synthase favors the
            abortive catalytic cycle and uncovers a latent potential for
            hexamer formation
  JOURNAL   Biochemistry 54 (3), 807-819 (2015)
   PUBMED   25521717
  REMARK    GeneRIF: The persistence of a latent hexamer-building interface in
            the human enzyme suggests that the ancestral UXS may have been a
            hexamer.
REFERENCE   3  (bases 1 to 1876)
  AUTHORS   Polizzi,S.J., Walsh,R.M. Jr., Le Magueres,P., Criswell,A.R. and
            Wood,Z.A.
  TITLE     Human UDP-alpha-d-xylose synthase forms a catalytically important
            tetramer that has not been observed in crystal structures
  JOURNAL   Biochemistry 52 (22), 3888-3898 (2013)
   PUBMED   23656592
  REMARK    GeneRIF: hUXS forms a tetramer in solution that is important for
            activity. The higher activity of the tetramer coupled with the
            relative instability of the dimeric complex suggests that an
            association-dissociation mechanism may regulate hUXS activity.
REFERENCE   4  (bases 1 to 1876)
  AUTHORS   Polizzi,S.J., Walsh,R.M. Jr., Peeples,W.B., Lim,J.M., Wells,L. and
            Wood,Z.A.
  TITLE     Human UDP-alpha-D-xylose synthase and Escherichia coli ArnA
            conserve a conformational shunt that controls whether xylose or
            4-keto-xylose is produced
  JOURNAL   Biochemistry 51 (44), 8844-8855 (2012)
   PUBMED   23072385
REFERENCE   5  (bases 1 to 1876)
  AUTHORS   Eixelsberger,T., Sykora,S., Egger,S., Brunsteiner,M.,
            Kavanagh,K.L., Oppermann,U., Brecker,L. and Nidetzky,B.
  TITLE     Structure and mechanism of human UDP-xylose synthase: evidence for
            a promoting role of sugar ring distortion in a three-step catalytic
            conversion of UDP-glucuronic acid
  JOURNAL   J Biol Chem 287 (37), 31349-31358 (2012)
   PUBMED   22810237
REFERENCE   6  (bases 1 to 1876)
  AUTHORS   Persson,B., Kallberg,Y., Bray,J.E., Bruford,E., Dellaporta,S.L.,
            Favia,A.D., Duarte,R.G., Jornvall,H., Kavanagh,K.L., Kedishvili,N.,
            Kisiela,M., Maser,E., Mindnich,R., Orchard,S., Penning,T.M.,
            Thornton,J.M., Adamski,J. and Oppermann,U.
  TITLE     The SDR (short-chain dehydrogenase/reductase and related enzymes)
            nomenclature initiative
  JOURNAL   Chem Biol Interact 178 (1-3), 94-98 (2009)
   PUBMED   19027726
REFERENCE   7  (bases 1 to 1876)
  AUTHORS   Gonzalez-Begne,M., Lu,B., Han,X., Hagen,F.K., Hand,A.R.,
            Melvin,J.E. and Yates,J.R.
  TITLE     Proteomic analysis of human parotid gland exosomes by
            multidimensional protein identification technology (MudPIT)
  JOURNAL   J Proteome Res 8 (3), 1304-1314 (2009)
   PUBMED   19199708
REFERENCE   8  (bases 1 to 1876)
  AUTHORS   Bakker,H., Oka,T., Ashikov,A., Yadav,A., Berger,M., Rana,N.A.,
            Bai,X., Jigami,Y., Haltiwanger,R.S., Esko,J.D. and
            Gerardy-Schahn,R.
  TITLE     Functional UDP-xylose transport across the endoplasmic
            reticulum/Golgi membrane in a Chinese hamster ovary cell mutant
            defective in UDP-xylose Synthase
  JOURNAL   J Biol Chem 284 (4), 2576-2583 (2009)
   PUBMED   19028698
  REMARK    GeneRIF: Complementation was achieved by expression of a
            cytoplasmic variant of UDP-xylose Synthase, which proves the
            existence of a functional Golgi UDP-xylose transporter[UDP-xylose
            Synthase]
REFERENCE   9  (bases 1 to 1876)
  AUTHORS   Hwang,H.Y. and Horvitz,H.R.
  TITLE     The SQV-1 UDP-glucuronic acid decarboxylase and the SQV-7
            nucleotide-sugar transporter may act in the Golgi apparatus to
            affect Caenorhabditis elegans vulval morphogenesis and embryonic
            development
  JOURNAL   Proc Natl Acad Sci U S A 99 (22), 14218-14223 (2002)
   PUBMED   12391314
REFERENCE   10 (bases 1 to 1876)
  AUTHORS   Moriarity,J.L., Hurt,K.J., Resnick,A.C., Storm,P.B., Laroy,W.,
            Schnaar,R.L. and Snyder,S.H.
  TITLE     UDP-glucuronate decarboxylase, a key enzyme in proteoglycan
            synthesis: cloning, characterization, and localization
  JOURNAL   J Biol Chem 277 (19), 16968-16975 (2002)
   PUBMED   11877387
  REMARK    GeneRIF: UDP-glucuronate decarboxylase, a key enzyme in
            proteoglycan synthesis: cloning, characterization, and
            localization.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC018878.8.
            
            On Jan 16, 2020 this sequence version replaced XM_017005009.1.
            
            Summary: This gene encodes an enzyme found in the perinuclear Golgi
            which catalyzes the synthesis of UDP-xylose used in
            glycosaminoglycan (GAG) synthesis on proteoglycans. The GAG chains
            are covalently attached to proteoglycans which participate in
            signaling pathways during development. Multiple transcript variants
            encoding different isoforms have been found for this gene.
            [provided by RefSeq, Dec 2014].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660809.80970.1,
                                           SRR14038196.738139.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-154               AC018878.8         164932-165085       c
            155-182             AC018878.8         136840-136867       c
            183-231             AC018878.8         135520-135568       c
            232-275             AC018878.8         134451-134494       c
            276-336             AC018878.8         128842-128902       c
            337-517             AC018878.8         115974-116154       c
            518-622             AC018878.8         100458-100562       c
            623-682             AC018878.8         96404-96463         c
            683-804             AC018878.8         93754-93875         c
            805-924             AC018878.8         83430-83549         c
            925-968             AC018878.8         75578-75621         c
            969-1029            AC018878.8         71842-71902         c
            1030-1876           AC018878.8         64095-64941         c
FEATURES             Location/Qualifiers
     source          1..1876
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2q12.2"
     gene            1..1876
                     /gene="UXS1"
                     /gene_synonym="hUXS; hUXS1; SDR6E1; UGD"
                     /note="UDP-glucuronate decarboxylase 1"
                     /db_xref="GeneID:80146"
                     /db_xref="HGNC:HGNC:17729"
                     /db_xref="MIM:609749"
     exon            1..154
                     /gene="UXS1"
                     /gene_synonym="hUXS; hUXS1; SDR6E1; UGD"
                     /inference="alignment:Splign:2.1.0"
     CDS             61..1161
                     /gene="UXS1"
                     /gene_synonym="hUXS; hUXS1; SDR6E1; UGD"
                     /EC_number="4.1.1.35"
                     /note="isoform 5 is encoded by transcript variant 6; short
                     chain dehydrogenase/reductase family 6E, member 12;
                     UDP-glucuronic acid decarboxylase 1; UXS-1"
                     /codon_start=1
                     /product="UDP-glucuronic acid decarboxylase 1 isoform 5"
                     /protein_id="NP_001364434.1"
                     /db_xref="GeneID:80146"
                     /db_xref="HGNC:HGNC:17729"
                     /db_xref="MIM:609749"
                     /translation="MVSKALLRLVSAVNRRRMKLLLGIALLAYVASVWGNFVNMRSIQ
                     ENGELKIESKIEEMVEPLREKIRDLEKSFTQKYPPVKFLSEKDRKRILITGGAGFVGS
                     HLTDKLMMDGHEVTVVDNFFTGRKRNVEHWIGHENFELINHDVVEPLYIEVDQIYHLA
                     SPASPPNYMYNPIKTLKTNTIGTLNMLGLAKRVGARLLLASTSEVYGDPEVHPQSEDY
                     WGHVNPIGPRACYDEGKRVAETMCYAYMKQEGVEVRVARIFNTFGPRMHMNDGRVVSN
                     FILQALQGEPLTVYGSGSQTRAFQYVSDLVNGLVALMNSNVSSPVNLVPLEEGLNKAI
                     HYFRKELEYQANNQYIPKPKPARIKKGRTRHS"
     exon            155..182
                     /gene="UXS1"
                     /gene_synonym="hUXS; hUXS1; SDR6E1; UGD"
                     /inference="alignment:Splign:2.1.0"
     exon            183..231
                     /gene="UXS1"
                     /gene_synonym="hUXS; hUXS1; SDR6E1; UGD"
                     /inference="alignment:Splign:2.1.0"
     exon            232..275
                     /gene="UXS1"
                     /gene_synonym="hUXS; hUXS1; SDR6E1; UGD"
                     /inference="alignment:Splign:2.1.0"
     exon            276..336
                     /gene="UXS1"
                     /gene_synonym="hUXS; hUXS1; SDR6E1; UGD"
                     /inference="alignment:Splign:2.1.0"
     exon            337..517
                     /gene="UXS1"
                     /gene_synonym="hUXS; hUXS1; SDR6E1; UGD"
                     /inference="alignment:Splign:2.1.0"
     exon            518..622
                     /gene="UXS1"
                     /gene_synonym="hUXS; hUXS1; SDR6E1; UGD"
                     /inference="alignment:Splign:2.1.0"
     exon            623..682
                     /gene="UXS1"
                     /gene_synonym="hUXS; hUXS1; SDR6E1; UGD"
                     /inference="alignment:Splign:2.1.0"
     exon            683..804
                     /gene="UXS1"
                     /gene_synonym="hUXS; hUXS1; SDR6E1; UGD"
                     /inference="alignment:Splign:2.1.0"
     exon            805..924
                     /gene="UXS1"
                     /gene_synonym="hUXS; hUXS1; SDR6E1; UGD"
                     /inference="alignment:Splign:2.1.0"
     exon            925..968
                     /gene="UXS1"
                     /gene_synonym="hUXS; hUXS1; SDR6E1; UGD"
                     /inference="alignment:Splign:2.1.0"
     exon            969..1029
                     /gene="UXS1"
                     /gene_synonym="hUXS; hUXS1; SDR6E1; UGD"
                     /inference="alignment:Splign:2.1.0"
     exon            1030..1876
                     /gene="UXS1"
                     /gene_synonym="hUXS; hUXS1; SDR6E1; UGD"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1855..1860
                     /regulatory_class="polyA_signal_sequence"
                     /gene="UXS1"
                     /gene_synonym="hUXS; hUXS1; SDR6E1; UGD"
                     /note="hexamer: AATAAA"
     polyA_site      1876
                     /gene="UXS1"
                     /gene_synonym="hUXS; hUXS1; SDR6E1; UGD"
                     /note="major polyA site"
ORIGIN      
        1 gcattgtgca gcaggcgggc ccccgcgcgg tagggccctg gacccgcgcg gctcccgggg
       61 atggtgagca aggcgctgct gcgcctcgtg tctgccgtca accgcaggag gatgaagctg
      121 ctgctgggca tcgccttgct ggcctacgtc gcctctgttt ggggcaactt cgttaatatg
      181 aggtctatcc aggaaaatgg tgaactaaaa attgaaagca agattgaaga gatggttgaa
      241 ccactaagag agaaaatcag agatttagaa aaaagcttta cccagaaata cccaccagta
      301 aagtttttat cagaaaagga tcggaaaaga attttgataa caggaggcgc agggttcgtg
      361 ggctcccatc taactgacaa actcatgatg gacggccacg aggtgaccgt ggtggacaat
      421 ttcttcacgg gcaggaagag aaacgtggag cactggatcg gacatgagaa cttcgagttg
      481 attaaccacg acgtggtgga gcccctctac atcgaggttg accagatata ccatctggca
      541 tctccagcct cccctccaaa ctacatgtat aatcctatca agacattaaa gaccaatacg
      601 attgggacat taaacatgtt ggggctggca aaacgagtcg gtgcccgtct gctcctggcc
      661 tccacatcgg aggtgtatgg agatcctgaa gtccaccctc aaagtgagga ttactggggc
      721 cacgtgaatc caataggacc tcgggcctgc tacgatgaag gcaaacgtgt tgcagagacc
      781 atgtgctatg cctacatgaa gcaggaaggc gtggaagtgc gagtggccag aatcttcaac
      841 acctttgggc cacgcatgca catgaacgat gggcgagtag tcagcaactt catcctgcag
      901 gcgctccagg gggagccact cacggtatac ggatccgggt ctcagacaag ggcgttccag
      961 tacgtcagcg atctagtgaa tggcctcgtg gctctcatga acagcaacgt cagcagcccg
     1021 gtcaacctgg tcccgctgga ggaaggttta aacaaagcaa ttcactactt ccgtaaagaa
     1081 ctcgagtacc aggcaaataa tcagtacatc cccaaaccaa agcctgccag aataaagaaa
     1141 ggacggactc gccacagctg aactcctcac ttttaggaca caagactacc attgtacact
     1201 tgatgggatg tatttttggc ttttttttgt tgtcgtttaa agaaagactt taacaggtgt
     1261 catgaagaac aaactggaat ttcattctga agcttgcttt aatgaaatgg atgtgcctaa
     1321 aagctcccct caaaaaactg cagattttgc cttgcacttt ttgaatctct ctttttatgt
     1381 aaaatagcgt agatgcatct ctgcgtattt tcaagttttt ttatcttgct gtgagagcat
     1441 atgttgtgac tgtcgttgac agttttattt actggtttct ttgtgaagct gaaaaggaac
     1501 attaagcggg acaaaaaatg ccgattttat ttatgaaagt gggtacttaa taaatgagtc
     1561 gttatactat gcataaagaa aaatcctagc agtattgtca ggtggtggtg cgccggcatt
     1621 gattttaggg cagataaaag aattctgtgt gagagcttta tgtttctctt ttaattcaga
     1681 gtttttccaa ggtctacttt tgagttgcaa acttgacttt gaaatattcc tgttggtcat
     1741 gatcaaggat atttgaaatc actactgtgt tttgctgcgt atctggggcg ggggcaggtt
     1801 ggggggcaca aagttaacat attcttggtt aaccatggtt aaatatgcta ttttaataaa
     1861 ttattgaaac tcacca
//
