LOCUS       NM_020894               4773 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens UV stimulated scaffold protein A (UVSSA), transcript
            variant 1, mRNA.
ACCESSION   NM_020894 XM_042661
VERSION     NM_020894.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4773)
  AUTHORS   Mistry,H., Kumari,S., Aswal,V.K. and Gupta,G.D.
  TITLE     Structural characterization of transcription-coupled repair protein
            UVSSA and its interaction with TFIIH protein
  JOURNAL   Int J Biol Macromol 247, 125792 (2023)
   PUBMED   37442507
  REMARK    GeneRIF: Structural characterization of transcription-coupled
            repair protein UVSSA and its interaction with TFIIH protein.
REFERENCE   2  (bases 1 to 4773)
  AUTHORS   Mistry,H. and Gupta,G.D.
  TITLE     Transcription coupled DNA repair protein UVSSA binds to DNA and
            RNA: Mapping of nucleic acid interaction sites on human UVSSA
  JOURNAL   Arch Biochem Biophys 735, 109515 (2023)
   PUBMED   36623745
  REMARK    GeneRIF: Transcription coupled DNA repair protein UVSSA binds to
            DNA and RNA: Mapping of nucleic acid interaction sites on human
            UVSSA.
REFERENCE   3  (bases 1 to 4773)
  AUTHORS   Kordon,M.M., Arron,S., Cleaver,J.E., Bezrookove,V., Karentz,D.,
            Lu,B., Perr,E., Chang,D. and Pederson,T.
  TITLE     The UVSSA protein is part of a genome integrity homeostasis network
            with links to transcription-coupled DNA repair and ATM signaling
  JOURNAL   Proc Natl Acad Sci U S A 119 (11), e2116254119 (2022)
   PUBMED   35254895
  REMARK    GeneRIF: The UVSSA protein is part of a genome integrity
            homeostasis network with links to transcription-coupled DNA repair
            and ATM signaling.
REFERENCE   4  (bases 1 to 4773)
  AUTHORS   Schwertman,P., Vermeulen,W. and Marteijn,J.A.
  TITLE     UVSSA and USP7, a new couple in transcription-coupled DNA repair
  JOURNAL   Chromosoma 122 (4), 275-284 (2013)
   PUBMED   23760561
  REMARK    GeneRIF: UVSSA together with USP7 is implicated in regulating
            transcription-coupled DNA repair.[review]
            Review article
REFERENCE   5  (bases 1 to 4773)
  AUTHORS   Ogi,T., Nakazawa,Y., Sasaki,K., Guo,C., Yoshiura,K., Utani,A. and
            Nagayama,Y.
  TITLE     [Molecular cloning and characterisation of UVSSA, the responsible
            gene for UV-sensitive syndrome]
  JOURNAL   Seikagaku 85 (3), 133-144 (2013)
   PUBMED   23631307
  REMARK    GeneRIF: Human UVSSA protein is required for the ubiquitination of
            RNA polymerase and DNA repair after light-induced DNA damage
            [review].
            Review article
REFERENCE   6  (bases 1 to 4773)
  AUTHORS   Fei,J. and Chen,J.
  TITLE     KIAA1530 protein is recruited by Cockayne syndrome complementation
            group protein A (CSA) to participate in transcription-coupled
            repair (TCR)
  JOURNAL   J Biol Chem 287 (42), 35118-35126 (2012)
   PUBMED   22902626
  REMARK    GeneRIF: KIAA1530 is an important player in TCR but also lead to a
            better understanding of the molecular mechanism underlying UV(s)S
            syndrome.
REFERENCE   7  (bases 1 to 4773)
  AUTHORS   Zhang,X., Horibata,K., Saijo,M., Ishigami,C., Ukai,A., Kanno,S.,
            Tahara,H., Neilan,E.G., Honma,M., Nohmi,T., Yasui,A. and Tanaka,K.
  TITLE     Mutations in UVSSA cause UV-sensitive syndrome and destabilize
            ERCC6 in transcription-coupled DNA repair
  JOURNAL   Nat Genet 44 (5), 593-597 (2012)
   PUBMED   22466612
  REMARK    GeneRIF: Mutations in UVSSA cause UV-sensitive syndrome and
            destabilize ERCC6 in transcription-coupled DNA repair.
REFERENCE   8  (bases 1 to 4773)
  AUTHORS   Schwertman,P., Lagarou,A., Dekkers,D.H., Raams,A., van der
            Hoek,A.C., Laffeber,C., Hoeijmakers,J.H., Demmers,J.A.,
            Fousteri,M., Vermeulen,W. and Marteijn,J.A.
  TITLE     UV-sensitive syndrome protein UVSSA recruits USP7 to regulate
            transcription-coupled repair
  JOURNAL   Nat Genet 44 (5), 598-602 (2012)
   PUBMED   22466611
  REMARK    GeneRIF: Mutations in UVSSA cause UV-sensitive syndrome and
            recruits USP7 to regulate transcription-coupled repair.
REFERENCE   9  (bases 1 to 4773)
  AUTHORS   Nakazawa,Y., Sasaki,K., Mitsutake,N., Matsuse,M., Shimada,M.,
            Nardo,T., Takahashi,Y., Ohyama,K., Ito,K., Mishima,H., Nomura,M.,
            Kinoshita,A., Ono,S., Takenaka,K., Masuyama,R., Kudo,T., Slor,H.,
            Utani,A., Tateishi,S., Yamashita,S., Stefanini,M., Lehmann,A.R.,
            Yoshiura,K. and Ogi,T.
  TITLE     Mutations in UVSSA cause UV-sensitive syndrome and impair RNA
            polymerase IIo processing in transcription-coupled
            nucleotide-excision repair
  JOURNAL   Nat Genet 44 (5), 586-592 (2012)
   PUBMED   22466610
  REMARK    GeneRIF: Mutations in the UVSSA gene is associated with
            UV-sensitive syndrome.
REFERENCE   10 (bases 1 to 4773)
  AUTHORS   Yashin,A.I., Wu,D., Arbeev,K.G. and Ukraintseva,S.V.
  TITLE     Joint influence of small-effect genetic variants on human longevity
  JOURNAL   Aging (Albany NY) 2 (9), 612-620 (2010)
   PUBMED   20834067
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC078852.5, AB040963.1,
            BC110331.1, EL735271.1, BC021930.1 and AL390128.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On May 17, 2019 this sequence version replaced NM_020894.3.
            
            Summary: The protein encoded by this gene appears to be involved in
            ubiquitination and dephosphorylation of RNA polymerase II subunits
            that stall after UV irradiation. The encoded protein interacts with
            several members of the nucleotide excision repair complex, and is
            thought to be involved in the transcription-coupled nucleotide
            excision repair (TC-NER) pathway to help remove lesions in the DNA
            that block transcription. Defects in this gene can cause
            UV-sensitive syndrome 3. Alternative splicing results in multiple
            transcript variants. [provided by RefSeq, Dec 2015].
            
            Transcript Variant: This variant (1) represents the longest
            transcript. Variants 1, 2 and 3 encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB040963.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2142670, SAMEA2153347
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000389851.10/ ENSP00000374501.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-108               AC078852.5         59518-59625
            109-295             AB040963.1         1-187
            296-296             AC078852.5         59813-59813
            297-746             AB040963.1         189-638
            747-2334            BC110331.1         538-2125
            2335-2533           EL735271.1         433-631
            2534-2968           AB040963.1         2426-2860
            2969-3138           BC021930.1         1499-1668
            3139-4773           AL390128.1         3185-4819
FEATURES             Location/Qualifiers
     source          1..4773
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4p16.3"
     gene            1..4773
                     /gene="UVSSA"
                     /gene_synonym="KIAA1530; UVSS3"
                     /note="UV stimulated scaffold protein A"
                     /db_xref="GeneID:57654"
                     /db_xref="HGNC:HGNC:29304"
                     /db_xref="MIM:614632"
     exon            1..553
                     /gene="UVSSA"
                     /gene_synonym="KIAA1530; UVSS3"
                     /inference="alignment:Splign:2.1.0"
     exon            554..653
                     /gene="UVSSA"
                     /gene_synonym="KIAA1530; UVSS3"
                     /inference="alignment:Splign:2.1.0"
     CDS             556..2685
                     /gene="UVSSA"
                     /gene_synonym="KIAA1530; UVSS3"
                     /codon_start=1
                     /product="UV-stimulated scaffold protein A"
                     /protein_id="NP_065945.2"
                     /db_xref="CCDS:CCDS33938.1"
                     /db_xref="GeneID:57654"
                     /db_xref="HGNC:HGNC:29304"
                     /db_xref="MIM:614632"
                     /translation="MDQKLSKLVEELTTSGEPRLNPEKMKELKKICKSSEEQLSRAYR
                     LLIAQLTQEHAEIRLSAFQIVEELFVRSHQFRMLVVSNFQEFLELTLGTDPAQPLPPP
                     REAAQRLRQATTRAVEGWNEKFGEAYKKLALGYHFLRHNKKVDFQDTNARSLAERKRE
                     EEKQKHLDKIYQERASQAEREMQEMSGEIESCLTEVESCFRLLVPFDFDPNPETESLG
                     MASGMSDALRSSCAGQVGPCRSGTPDPRDGEQPCCSRDLPASAGHPRAGGGAQPSQTA
                     TGDPSDEDEDSDLEEFVRSHGLGSHKYTLDVELCSEGLKVQENEDNLALIHAARDTLK
                     LIRNKFLPAVCSWIQRFTRVGTHGGCLKRAIDLKAELELVLRKYKELDIEPEGGERRR
                     TEALGDAEEDEDDEDFVEVPEKEGYEPHIPDHLRPEYGLEAAPEKDTVVRCLRTRTRM
                     DEEVSDPTSAAAQLRQLRDHLPPPSSASPSRALPEPQEAQKLAAERARAPVVPYGVDL
                     HYWGQELPTAGKIVKSDSQHRFWKPSEVEEEVVNADISEMLRSRHITFAGKFEPVQHW
                     CRAPRPDGRLCERQDRLKCPFHGKIVPRDDEGRPLDPEDRAREQRRQLQKQERPEWQD
                     PELMRDVEAATGQDLGSSRYSGKGRGKKRRYPSLTNLKAQADTARARIGRKVFAKAAV
                     RRVVAAMNRMDQKKHEKFSNQFNYALN"
     exon            654..984
                     /gene="UVSSA"
                     /gene_synonym="KIAA1530; UVSS3"
                     /inference="alignment:Splign:2.1.0"
     exon            985..1105
                     /gene="UVSSA"
                     /gene_synonym="KIAA1530; UVSS3"
                     /inference="alignment:Splign:2.1.0"
     exon            1106..1489
                     /gene="UVSSA"
                     /gene_synonym="KIAA1530; UVSS3"
                     /inference="alignment:Splign:2.1.0"
     exon            1490..1602
                     /gene="UVSSA"
                     /gene_synonym="KIAA1530; UVSS3"
                     /inference="alignment:Splign:2.1.0"
     exon            1603..1731
                     /gene="UVSSA"
                     /gene_synonym="KIAA1530; UVSS3"
                     /inference="alignment:Splign:2.1.0"
     exon            1732..1843
                     /gene="UVSSA"
                     /gene_synonym="KIAA1530; UVSS3"
                     /inference="alignment:Splign:2.1.0"
     exon            1844..1988
                     /gene="UVSSA"
                     /gene_synonym="KIAA1530; UVSS3"
                     /inference="alignment:Splign:2.1.0"
     exon            1989..2123
                     /gene="UVSSA"
                     /gene_synonym="KIAA1530; UVSS3"
                     /inference="alignment:Splign:2.1.0"
     exon            2124..2307
                     /gene="UVSSA"
                     /gene_synonym="KIAA1530; UVSS3"
                     /inference="alignment:Splign:2.1.0"
     exon            2308..2416
                     /gene="UVSSA"
                     /gene_synonym="KIAA1530; UVSS3"
                     /inference="alignment:Splign:2.1.0"
     exon            2417..2591
                     /gene="UVSSA"
                     /gene_synonym="KIAA1530; UVSS3"
                     /inference="alignment:Splign:2.1.0"
     exon            2592..4773
                     /gene="UVSSA"
                     /gene_synonym="KIAA1530; UVSS3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4753..4758
                     /regulatory_class="polyA_signal_sequence"
                     /gene="UVSSA"
                     /gene_synonym="KIAA1530; UVSS3"
                     /note="hexamer: ATTAAA"
     polyA_site      4773
                     /gene="UVSSA"
                     /gene_synonym="KIAA1530; UVSS3"
                     /note="major polyA site"
ORIGIN      
        1 gaggcgagcg gccgcgtcag cggtaggtgg ggctgtggtt acgctgccgg gcgggggtcg
       61 cgccggttcg gtccccgggg ctctgcgggc gccgggcaga gacctgcggc cagggcgtgt
      121 cccgtgtgcc cgagagcgcc ggcggcgggg ccggagggcg ggccctgggc cgagtgacag
      181 gccgcagccc cccgagcacc gtcgaagccg gcgcgcccgc ccggtgcagc cgctgtgcga
      241 gagcgacccc gcggtccaag cctcgcgtgg ccctgccggg ccccttcttt ccccgagtag
      301 ggcgcagctt cccagcctcc gccccggcct cgcctggcgc ttccttccgg gtccttcggc
      361 ctttccctgg cggtgcggca ggccctcgcc tcatcccacc aggcacgccg cggtgctcgg
      421 ccctgggtat ccgggcaggc tgcctccgtt agggccgccc ctgctctccg gacgcgactt
      481 ttcattggtc tcagaatttc ttggctcctc ttggcctctg cagccttgct ggaggctgcc
      541 ctgcggaatc tgaatatgga tcagaaactt tcgaagttgg tagaagagct cacaacttca
      601 ggagaacccc gactaaatcc tgagaaaatg aaggaactga agaaaatttg caagtcttca
      661 gaggagcagc tgagccgcgc ctaccgcctg ctgatagcac agctgaccca ggagcacgcc
      721 gagatccgtc tctcagcctt ccagattgtg gaggaactct tcgtcaggtc tcaccagttc
      781 cggatgctgg ttgtttccaa cttccaggag ttcctggagc tcacgctggg cacagacccc
      841 gcacagcctc tgccgccccc cagggaggcg gcacagaggc tgaggcaggc gaccacccgg
      901 gccgtggaag ggtggaatga gaagtttggg gaggcctaca agaagcttgc cttgggctac
      961 cacttcttaa gacacaacaa aaaggtggat tttcaagaca cgaatgctcg gagtctggca
     1021 gaaaggaaga gagaagagga gaagcagaag cacttggata aaatttatca agaaagagcc
     1081 agccaggcgg agagggagat gcaagaaatg tctggagaaa ttgaatcctg cttgacggag
     1141 gtagagagct gctttaggct gctggtgcct tttgactttg acccgaaccc ggagacggaa
     1201 tcccttggca tggcttctgg catgtccgat gcccttcgct cctcctgcgc gggccaggtg
     1261 ggcccctgcc ggtctggcac ccctgacccc cgggacgggg agcagccctg ctgcagtaga
     1321 gacctgcctg cctctgcagg ccaccccaga gcgggcggcg gggcacagcc atcccagaca
     1381 gccacaggtg acccctcaga tgaggacgag gacagcgacc tcgaggagtt tgtgcggagc
     1441 cacgggctgg gctcgcacaa gtacacgctg gatgtggagc tctgctcaga gggcctgaag
     1501 gtgcaggaga acgaggacaa ccttgctctc atccacgccg cccgcgacac actcaagctc
     1561 atccggaaca agttcctgcc ggctgtgtgc tcgtggatcc agcgcttcac ccgcgtcggg
     1621 acccacggtg gatgtttaaa gcgtgccatt gacctgaagg ctgaattgga gctcgtactg
     1681 agaaaataca aggagctgga catcgagcct gagggagggg aaaggcgcag gacagaagcc
     1741 ctgggggatg cggaggaaga tgaggacgat gaggactttg tggaggtccc tgagaaggag
     1801 gggtatgagc cacacatccc cgaccacttg cggcctgagt atgggctgga ggcagcacca
     1861 gagaaagaca cagttgtgcg gtgcttgcgg acgaggacga ggatggacga ggaggtgtcg
     1921 gaccccacct ctgcggctgc tcagctgcgg cagctccggg accacttgcc tccaccctca
     1981 tctgccagcc cctccagagc gttgccagag ccacaggagg cccagaagct ggcagcagag
     2041 cgggcccggg cgcctgtggt gccctacggc gtggacctgc actactgggg ccaggagctc
     2101 cccacagccg ggaagattgt caagtctgac tcccagcacc gcttctggaa gcccagcgag
     2161 gtggaggagg aagtggtcaa tgccgacatc tccgagatgc tccggagccg ccacatcact
     2221 tttgccggga agtttgagcc tgtgcagcac tggtgccgtg ccccgaggcc agacggccgg
     2281 ctctgtgagc gccaagaccg gctgaagtgc cctttccatg ggaagattgt tccacgggac
     2341 gacgaaggac ggccgctcga cccggaagac agggctcgtg agcagcggcg gcagctgcag
     2401 aagcaggagc gcccggaatg gcaggaccct gagttgatga gagacgtgga agcagccaca
     2461 gggcaggatc tcggctcatc caggtacagc gggaaaggca gggggaagaa gaggaggtac
     2521 cccagcctca ccaacctgaa ggctcaggct gataccgccc gcgctcgcat tgggagaaaa
     2581 gtcttcgcca aggcagctgt gcggagggta gtggcagcca tgaaccggat ggaccagaag
     2641 aagcacgaga agttttcaaa ccagtttaac tacgcactga actagagagc ggggcccagt
     2701 gcactggcca tcagcacttt ctccctctgc cagtgtctca ggacagcaga gtgggcgtgg
     2761 gtctgggcag taaccatgct ttgtctatta ctgtgtttga tgtaaagaaa tggtgtgttg
     2821 caatgccctg aaggtacggc cgctctgctg ctacagggtt cggcatcgtc tggtgatggg
     2881 tctggcctcg cagaagaggc cctcgggcct ggagatgtga acacaggcag cgaccctgtt
     2941 ccagagggct tctgcgagtc ctcgtgagac cagtgcttgt cgtggtgtgg ggttcagcac
     3001 ggacggaatg tgtgtgcagc tcagccttca gagcgtgcat tccccagcca ggaggcgacc
     3061 actcagagga actctgggaa acccactttt gtgcaaatgc tgtttttaac acaaacacaa
     3121 aggctagtga accgttcagt catctgcttt ctgtttctgg atgtgccttt tcatacatgt
     3181 gtcctcttgt ccctggcttc ttacacttgg cgttgttttt aaggtttatc catgcagttc
     3241 ccctccaatg tataaaacaa aggaggtgaa aacctgtcca tgcggaagct tgtgcaccca
     3301 tgttcacagc agcattggag aaggataccg aacatcttct cgtgggctta ctggccattt
     3361 gtgtatctcc tttggagagg agtctattca aacctcttgc ctatttttaa ttgaatgatt
     3421 tatcttgagt tgtaacagtt gttttttttg tttttccttt tagagatggg cttttgctct
     3481 tacccaggct gagtgcagtg gcagaatcat agctcagtgc agcctcaaac tcctgggctc
     3541 aagccatcct tccacgtcag cctcccaggt agctgggact acaggcacac accacaacac
     3601 ctggctaatt ttttaaattt tttgtagaga tgaggtctca ctgtgttgcc cacggtgatc
     3661 tcgaactcct agcctcaagc gatcctcctg cttcggtctc ccaaagtgtt gggattacag
     3721 gcatgagcca ccactcctgg ccaggagttt atatgtatac tgtggatact agatcctcat
     3781 gtgatttgca aaaactttat ttatttattt atttattttt gaaatggaat cttgctctgt
     3841 cgccaggctg gagtgcaatg gcgtgatctc ggctcactgc aactaccacc tcctgggttc
     3901 aagcgattcg cctgcgtcag cgtcctgagt agctgggact acaggcgcgc accaccacgc
     3961 ccagctaatt tttgtatttt tagtagagac gggatttcac tgtgttggct gggatggtct
     4021 tgatctcttg acctcgtgat ccacccacct cggcctccca tagtgctggg attacaggtg
     4081 tgagccaccg cactcagctg atttgcaaaa actttcttcc atactgttgt ttcactttct
     4141 ggatagtgtc ctctgaagca caaaagttaa ttttgatgaa gtacagcaat ttatctgttt
     4201 ttttcttttg ttgcttatgc ttttgctgtc acatttcaga agccatcacc taatccaaga
     4261 tcacagagat ttacacctag tttctaataa gcattttata atttcagctc ttatgtgtag
     4321 atctttgatc cattgtgaat taagttttgt gtgtggtgta agagcccaca ttcttttgca
     4381 tgtggatatc cagttgtccc agcaccattt gttgaaaaca ttatttttcc ccattgaatt
     4441 atcttcgcac cattattgat aatcagttga ccaaaaatgt acaggcttat ttctgggcac
     4501 ttgactctat tccattgacc tgtttaacct tatgccagtg ccacagtgcc ttgatcagtg
     4561 ctgctttgtt gtgagaagtt ttactttgtt ctgcttcaag gctgttttga ctcttctgca
     4621 tctcttgcat ttccaaatga attttaggat ccactcatca gtttcttcaa aaaaaaaaaa
     4681 aaagcagctg agatttttga taggaattac attaaatcta gagattgctt tggaatgtat
     4741 taccgtctta atattaaatc ttctgagtca tga
//
