LOCUS       NM_003369               5117 bp    mRNA    linear   PRI 12-DEC-2024
DEFINITION  Homo sapiens UV radiation resistance associated (UVRAG), transcript
            variant 2, mRNA.
ACCESSION   NM_003369
VERSION     NM_003369.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5117)
  AUTHORS   Qian,X., Sun,J. and Cui,Y.
  TITLE     UVRAG: orchestrating the initiation of reticulophagy
  JOURNAL   Autophagy 20 (3), 712-713 (2024)
   PUBMED   38054642
  REMARK    GeneRIF: UVRAG: orchestrating the initiation of reticulophagy.
REFERENCE   2  (bases 1 to 5117)
  AUTHORS   Kliche,J., Garvanska,D.H., Simonetti,L., Badgujar,D.,
            Dobritzsch,D., Nilsson,J., Davey,N.E. and Ivarsson,Y.
  TITLE     Large-scale phosphomimetic screening identifies phospho-modulated
            motif-based protein interactions
  JOURNAL   Mol Syst Biol 19 (7), e11164 (2023)
   PUBMED   37219487
REFERENCE   3  (bases 1 to 5117)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   4  (bases 1 to 5117)
  AUTHORS   Benz,C., Ali,M., Krystkowiak,I., Simonetti,L., Sayadi,A.,
            Mihalic,F., Kliche,J., Andersson,E., Jemth,P., Davey,N.E. and
            Ivarsson,Y.
  TITLE     Proteome-scale mapping of binding sites in the unstructured regions
            of the human proteome
  JOURNAL   Mol Syst Biol 18 (1), e10584 (2022)
   PUBMED   35044719
REFERENCE   5  (bases 1 to 5117)
  AUTHORS   Xu,C., Wu,J., Wu,Y., Ren,Z., Yao,Y., Chen,G., Fang,E.F., Noh,J.H.,
            Liu,Y.U., Wei,L., Chen,X. and Sima,J.
  TITLE     TNF-alpha-dependent neuronal necroptosis regulated in Alzheimer's
            disease by coordination of RIPK1-p62 complex with autophagic UVRAG
  JOURNAL   Theranostics 11 (19), 9452-9469 (2021)
   PUBMED   34646380
  REMARK    GeneRIF: TNF-alpha-dependent neuronal necroptosis regulated in
            Alzheimer's disease by coordination of RIPK1-p62 complex with
            autophagic UVRAG.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 5117)
  AUTHORS   Iida,A., Emi,M., Matsuoka,R., Hiratsuka,E., Okui,K., Ohashi,H.,
            Inazawa,J., Fukushima,Y., Imai,T. and Nakamura,Y.
  TITLE     Identification of a gene disrupted by inv(11)(q13.5;q25) in a
            patient with left-right axis malformation
  JOURNAL   Hum Genet 106 (3), 277-287 (2000)
   PUBMED   10798355
REFERENCE   7  (bases 1 to 5117)
  AUTHORS   Perelman,B., Dafni,N., Naiman,T., Eli,D., Yaakov,M., Feng,T.L.,
            Sinha,S., Weber,G., Khodaei,S., Sancar,A., Dotan,I. and Canaani,D.
  TITLE     Molecular cloning of a novel human gene encoding a 63-kDa protein
            and its sublocalization within the 11q13 locus
  JOURNAL   Genomics 41 (3), 397-405 (1997)
   PUBMED   9169138
REFERENCE   8  (bases 1 to 5117)
  AUTHORS   Panaretou,C., Domin,J., Cockcroft,S. and Waterfield,M.D.
  TITLE     Characterization of p150, an adaptor protein for the human
            phosphatidylinositol (PtdIns) 3-kinase. Substrate presentation by
            phosphatidylinositol transfer protein to the p150.Ptdins 3-kinase
            complex
  JOURNAL   J Biol Chem 272 (4), 2477-2485 (1997)
   PUBMED   8999962
REFERENCE   9  (bases 1 to 5117)
  AUTHORS   Bekri,S., Adelaide,J., Merscher,S., Grosgeorge,J., Caroli-Bosc,F.,
            Perucca-Lostanlen,D., Kelley,P.M., Pebusque,M.J., Theillet,C.,
            Birnbaum,D. and Gaudray,P.
  TITLE     Detailed map of a region commonly amplified at 11q13-->q14 in human
            breast carcinoma
  JOURNAL   Cytogenet Cell Genet 79 (1-2), 125-131 (1997)
   PUBMED   9533029
REFERENCE   10 (bases 1 to 5117)
  AUTHORS   Teitz,T., Penner,M., Eli,D., Stark,M., Bakhanashvili,M., Naiman,T.
            and Canaani,D.
  TITLE     Isolation by polymerase chain reaction of a cDNA whose product
            partially complements the ultraviolet sensitivity of xeroderma
            pigmentosum group C cells
  JOURNAL   Gene 87 (2), 295-298 (1990)
   PUBMED   2332174
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DB087351.1, AB012958.1 and
            AP002340.3.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_003369.3.
            
            Summary: This gene complements the ultraviolet sensitivity of
            xeroderma pigmentosum group C cells and encodes a protein with a C2
            domain. The protein activates the Beclin1-PI(3)KC3 complex,
            promoting autophagy and suppressing the proliferation and
            tumorigenicity of human colon cancer cells. Chromosomal aberrations
            involving this gene are associated with left-right axis
            malformation and mutations in this gene have been associated with
            colon cancer. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660807.160384.1,
                                           SRR1660805.180317.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000356136.8/ ENSP00000348455.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-20                DB087351.1         44-63
            21-3535             AB012958.1         1-3515
            3536-5117           AP002340.3         145998-147579
FEATURES             Location/Qualifiers
     source          1..5117
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q13.5"
     gene            1..5117
                     /gene="UVRAG"
                     /gene_synonym="DHTX; p63; VPS38"
                     /note="UV radiation resistance associated"
                     /db_xref="GeneID:7405"
                     /db_xref="HGNC:HGNC:12640"
                     /db_xref="MIM:602493"
     exon            1..315
                     /gene="UVRAG"
                     /gene_synonym="DHTX; p63; VPS38"
                     /inference="alignment:Splign:2.1.0"
     CDS             199..2298
                     /gene="UVRAG"
                     /gene_synonym="DHTX; p63; VPS38"
                     /note="isoform 2 is encoded by transcript variant 2;
                     beclin 1 binding protein; disrupted in heterotaxy; UV
                     radiation resistance-associated gene protein"
                     /codon_start=1
                     /product="UV radiation resistance-associated gene protein
                     isoform 2"
                     /protein_id="NP_003360.2"
                     /db_xref="CCDS:CCDS8241.1"
                     /db_xref="GeneID:7405"
                     /db_xref="HGNC:HGNC:12640"
                     /db_xref="MIM:602493"
                     /translation="MSASASVGGPVPQPPPGPAAALPPGSAARALHVELPSQQRRLRH
                     LRNIAARNIVNRNGHQLLDTYFTLHLCSTEKIYKEFYRSEVIKNSLNPTWRSLDFGIM
                     PDRLDTSVSCFVVKIWGGKENIYQLLIEWKVCLDGLKYLGQQIHARNQNEIIFGLNDG
                     YYGAPFEHKGYSNAQKTILLQVDQNCVRNSYDVFSLLRLHRAQCAIKQTQVTVQKIGK
                     EIEEKLRLTSTSNELKKKSECLQLKILVLQNELERQKKALGREVALLHKQQIALQDKG
                     SAFSAEHLKLQLQKESLNELRKECTAKRELFLKTNAQLTIRCRQLLSELSYIYPIDLN
                     EHKDYFVCGVKLPNSEDFQAKDDGSIAVALGYTAHLVSMISFFLQVPLRYPIIHKGSR
                     STIKDNINDKLTEKEREFPLYPKGGEKLQFDYGVYLLNKNIAQLRYQHGLGTPDLRQT
                     LPNLKNFMEHGLMVRCDRHHTSSAIPVPKRQSSIFGGADVGFSGGIPSPDKGHRKRAS
                     SENERLQYKTPPPSYNSALAQPVTTVPSMGETERKITSLSSSLDTSLDFSKENKKKGE
                     DLVGSLNGGHANVHPSQEQGEALSGHRATVNGTLLPSEQAGSASVQLPGEFHPVSEAE
                     LCCTVEQAEEIIGLEATGFASGDQLEAFNCIPVDSAVAVECDEQVLGEFEEFSRRIYA
                     LNENVSSFRRPRRSSDK"
     exon            316..433
                     /gene="UVRAG"
                     /gene_synonym="DHTX; p63; VPS38"
                     /inference="alignment:Splign:2.1.0"
     exon            434..468
                     /gene="UVRAG"
                     /gene_synonym="DHTX; p63; VPS38"
                     /inference="alignment:Splign:2.1.0"
     exon            469..630
                     /gene="UVRAG"
                     /gene_synonym="DHTX; p63; VPS38"
                     /inference="alignment:Splign:2.1.0"
     exon            631..705
                     /gene="UVRAG"
                     /gene_synonym="DHTX; p63; VPS38"
                     /inference="alignment:Splign:2.1.0"
     exon            706..791
                     /gene="UVRAG"
                     /gene_synonym="DHTX; p63; VPS38"
                     /inference="alignment:Splign:2.1.0"
     exon            792..897
                     /gene="UVRAG"
                     /gene_synonym="DHTX; p63; VPS38"
                     /inference="alignment:Splign:2.1.0"
     exon            898..1024
                     /gene="UVRAG"
                     /gene_synonym="DHTX; p63; VPS38"
                     /inference="alignment:Splign:2.1.0"
     exon            1025..1109
                     /gene="UVRAG"
                     /gene_synonym="DHTX; p63; VPS38"
                     /inference="alignment:Splign:2.1.0"
     exon            1110..1197
                     /gene="UVRAG"
                     /gene_synonym="DHTX; p63; VPS38"
                     /inference="alignment:Splign:2.1.0"
     exon            1198..1258
                     /gene="UVRAG"
                     /gene_synonym="DHTX; p63; VPS38"
                     /inference="alignment:Splign:2.1.0"
     exon            1259..1424
                     /gene="UVRAG"
                     /gene_synonym="DHTX; p63; VPS38"
                     /inference="alignment:Splign:2.1.0"
     exon            1425..1503
                     /gene="UVRAG"
                     /gene_synonym="DHTX; p63; VPS38"
                     /inference="alignment:Splign:2.1.0"
     exon            1504..1595
                     /gene="UVRAG"
                     /gene_synonym="DHTX; p63; VPS38"
                     /inference="alignment:Splign:2.1.0"
     exon            1596..5117
                     /gene="UVRAG"
                     /gene_synonym="DHTX; p63; VPS38"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3515..3520
                     /regulatory_class="polyA_signal_sequence"
                     /gene="UVRAG"
                     /gene_synonym="DHTX; p63; VPS38"
                     /note="hexamer: AATAAA"
     polyA_site      3536
                     /gene="UVRAG"
                     /gene_synonym="DHTX; p63; VPS38"
                     /note="major polyA site"
     regulatory      5097..5102
                     /regulatory_class="polyA_signal_sequence"
                     /gene="UVRAG"
                     /gene_synonym="DHTX; p63; VPS38"
                     /note="hexamer: AATAAA"
     polyA_site      5117
                     /gene="UVRAG"
                     /gene_synonym="DHTX; p63; VPS38"
ORIGIN      
        1 ggtaatatgg ctcttcctta gccagcggcg gcaacggcgg cagcggcggc agcggcggcg
       61 gctactgtct gggctgagca gtagtgcctc tcgggtggcg ggtttctagg ctgcaggggc
      121 ttggtaggtg gtggcaaggg ggcggcggcg gatgccggaa gagtgcccgc cccgccgctt
      181 ggcggcccct ggatcgagat gagcgcctcc gcgtcggtcg ggggccccgt cccccagcca
      241 cccccgggcc cggccgctgc tctgcctccc ggttctgccg cgcgggccct gcatgtggag
      301 ctgccgtctc agcagcggcg tcttcgacat cttcggaaca ttgctgcccg gaacattgtt
      361 aatagaaatg gccatcagct ccttgatacc tactttacac ttcacttgtg tagtactgaa
      421 aagatatata aagaatttta tagaagtgaa gtgattaaga attccttgaa tcccacgtgg
      481 cgaagtctcg attttggaat tatgccagac cgtcttgata catctgtgtc ttgtttcgtg
      541 gtgaagatat ggggtggaaa ggagaacatc taccagctgt tgattgaatg gaaagtctgt
      601 ttggatgggc tgaaatactt gggtcagcag attcatgccc gaaaccaaaa tgaaataatt
      661 tttgggctga atgatggata ctatggtgct ccatttgaac ataagggtta ttcaaatgct
      721 cagaagacta ttcttctgca ggtggatcag aactgtgttc gcaattctta cgatgtcttc
      781 tctttgctac ggcttcatag agcccagtgt gcaattaaac agactcaggt aactgttcag
      841 aaaattggaa aggaaattga agaaaaacta agactcacat ctacaagcaa tgaactgaaa
      901 aaaaaaagtg aatgcctgca gttaaaaatt ttggtgcttc agaatgaact ggaacggcag
      961 aagaaagctt tgggacggga ggtggcatta ctgcataagc aacaaattgc attacaagac
     1021 aaaggaagtg cattttcagc tgagcacctc aaacttcaac tccagaagga atccctaaat
     1081 gagctgagga aggagtgcac tgcaaaaaga gaactcttct tgaagactaa tgctcagttg
     1141 acaattcgtt gcaggcagtt actctctgag ctttcctaca tttaccctat tgatttgaat
     1201 gaacataagg attactttgt atgcggtgtc aagttgccta attctgagga cttccaagca
     1261 aaagatgatg gaagcattgc tgttgccctt ggttatactg cacatctggt ctccatgatt
     1321 tcctttttcc tacaagtgcc cctcagatat cctataattc ataaggggtc tagatcaaca
     1381 atcaaagaca atatcaatga caaactgacg gaaaaggaga gagagtttcc actgtatcca
     1441 aaaggagggg agaagttgca gtttgattat ggtgtctatc ttctgaacaa aaatatagca
     1501 cagctaagat atcaacatgg actagggact ccagacttgc ggcaaaccct tcccaacctg
     1561 aaaaacttca tggagcatgg actaatggtc aggtgtgaca gacatcacac ctccagtgca
     1621 atccctgttc ctaagagaca aagctccata tttgggggtg cagatgtagg cttctctggg
     1681 gggatccctt caccagacaa aggacatcga aaacgggcca gctctgagaa tgagagactt
     1741 cagtacaaaa cccctcctcc cagttacaac tcagcattag cccagcctgt gaccaccgtc
     1801 ccctccatgg gagagaccga gagaaagata acatctctat cctcctcctt ggatacctcc
     1861 ttggacttct ccaaagaaaa caagaaaaaa ggagaggatc tagttggcag cttaaacgga
     1921 ggccacgcga atgtgcaccc tagccaagaa caaggagaag ccctctccgg gcaccgggcc
     1981 acagtcaatg gcactctcct acccagcgag caggccgggt ccgccagtgt ccagcttcca
     2041 ggcgagttcc acccagtctc agaagctgag ctctgctgta ctgtggagca agcagaagaa
     2101 atcatcgggc tggaagccac aggtttcgcc tcaggtgatc agctagaagc atttaactgc
     2161 atcccagtgg acagtgctgt ggcagtagag tgtgacgaac aagttctggg agaatttgaa
     2221 gagttctccc gaaggatcta tgcactgaat gaaaacgtat ccagcttccg ccggccgcgc
     2281 aggagttccg ataagtgaag tgagcaggtc aacagtagga ctggggcaga agctctgcct
     2341 aaaatgaagt gaaagctgca cttaaccctt tgtgataatg atgacacaaa atgaatatta
     2401 atggaggata ttcctcggaa aaacagactt tgggaatgaa ggagggactc aggatcattg
     2461 ttatcagtgg gccaaagtta gattttgctt tcaagatttg cttttcgggc ctgatgattt
     2521 taaagcaaaa atcaccctct agttgaaaga gcttacagct cgagtcacct tttagctatt
     2581 tgtctgcttt ttatttaccc ttgtatgtta tcctcagagg gaagatgata atatataaat
     2641 aatataatga acacaccctt agtttctcat aagcatttgc cctcaccatg gtttataaaa
     2701 ctttgggaaa acggaatatt cagaaatagg tttccgccat gtactgaaag gtctgtggcc
     2761 atctgtgagg tagatgaaga agcagcatag tggtctcctt acatctaggc ctaactgtcc
     2821 ctcttcctgc ccccgggtac cacagtccac ctttagaccc tactgtcgcc ccatcttctc
     2881 cgtggatggg ccatgcgtcc tgaaaacagg acatcagatt cactggttct gtaacccagt
     2941 agctgtgacg ttccatctct tctaaccagc catggccttc ccctcctctg ccataccctt
     3001 aatgcggccc tcagattaga tgaaaaactt gctcctggtg gatcccaagg gaccctcaag
     3061 gacctcgagg ttactgcagt cagatgccat ctcatcccct gtgggggcca aagtttttat
     3121 gtgggcagat gctgtggtca ggaactaggc atgctttctg gcaatgcact caccagacaa
     3181 aaatcccttg atgtaaatcc catgttaatt tattaaattt cagtcagaag gtcagcattt
     3241 acatgacaga atgtatgtag agagttgggg tgtctggtag gcaaactgca aggcagttga
     3301 gatagttgga ttaagaggct agacgagaca tagaatacta ttggtatgtg tgcaatttca
     3361 tgaatattaa attatgtttc gaagtccagt tgtcattccc gcattcagat ttcatttgct
     3421 gttgctttat acgttacgta cccaaggaca ttgcctcagg gttgcaaact ctttaaagga
     3481 aaatttatcc atatatccat gtattatata gaagaataaa aattgagttt acttcacccg
     3541 acctgatttt tttttaccag cttggaaatt cctcttgaac ctacgtctcc atatgtcaca
     3601 tcatgacagg actagcctga acaaaagcca tgtctatcta agcggaggct gttgacttca
     3661 ttcagtttgc atattgtata tagcaacaca aacacttgac aggtatatac tccagtcgcc
     3721 acatttgtcc tgcataacag cttcactcac aggcctcacc gtcactttat tttgtgtcca
     3781 agcattcctg ggctcaagtt taatgtatag ctacattgtt gttttccatg tagagaactc
     3841 acaggatgac tacatcacaa ataaacccaa ctctcaggca gtcgaaagct ttaactggat
     3901 ctgcagaagc ccatcttcct ccacatgaag aagtggggct ccttcaccta gagcaggagc
     3961 ttctctgcag tgtactgtct gtcgctcatt ttggagtcag tgtgggtgga gacagcatcg
     4021 tggatatgca cgtgctgcgg ggccctccag ggaagtaaca tttaccaaaa aaaaagaaaa
     4081 gttctgaagg gcagtgttag gattgcagaa tggaaggtca accccgtggg acttacgatt
     4141 gccccaggtg cgggatggac ttaaatgtca caccaaactc aaagtaggta cactgggttg
     4201 cagggcatcc agcctggcgc tggcaccacc aaggagcagg actcctcatg attacagtgt
     4261 ccatctcagg cccacacaac catgagagcc tggactctgg ggtctacccg tcagtgcccc
     4321 ccaccgctgt gcagactccc tggttgatcc tgggcttgtg gcttttcacc gcacggcggg
     4381 gagccctgct cttgaatgtc atcgggctgc tcagagctga ttgctaggtg cctacacatt
     4441 tgcctcgacc cacacagccc cgtggtgatg cctcaaaaca ccacttaggt ttgggttcgt
     4501 ttagttcgag tttggggttt tcatttgaac ttgtttgatg tctgcagttt ctgccatgac
     4561 ctgggtagaa cctatgggat tacccgtctc ctggaataac tgtttgacgt tttccaaagt
     4621 tgtagagtta gtatggcctc tgtttaaagt ggctggggcc aaaataaggg atgagttatt
     4681 atctcctact aaccttttag ttttgtaaat cactaagaaa attgtttgct tggaagatat
     4741 aagttgaatt ggaaactcat tactatctat ttctgaactg ctaagaaccc tttcagtttt
     4801 cttacagctg agacactttt aaacagcggg caaatgttat caaatgaata tttgattgtg
     4861 ttttttctct tcacttcccc ttaaccactt tagaaattcc agagattttt ttcccctcag
     4921 aatattagtt ttggaagatt gtgcccagct atatattttt tagcagttct aatggtgccc
     4981 atttatcctg acctaaccag ttatttaaat aattttttaa accaccacga ataataaatg
     5041 gcatgtgaaa ctgatctgtt ggtaactgga agaaaactca gcatctgtat ttatacaata
     5101 aaattgatta gtattta
//
