LOCUS       NP_003360                699 aa            linear   PRI 28-APR-2025
DEFINITION  UV radiation resistance-associated gene protein isoform 2 [Homo
            sapiens].
ACCESSION   NP_003360
VERSION     NP_003360.2
DBSOURCE    REFSEQ: accession NM_003369.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (residues 1 to 699)
  AUTHORS   Qian,X., Sun,J. and Cui,Y.
  TITLE     UVRAG: orchestrating the initiation of reticulophagy
  JOURNAL   Autophagy 20 (3), 712-713 (2024)
   PUBMED   38054642
  REMARK    GeneRIF: UVRAG: orchestrating the initiation of reticulophagy.
REFERENCE   2  (residues 1 to 699)
  AUTHORS   Kliche,J., Garvanska,D.H., Simonetti,L., Badgujar,D.,
            Dobritzsch,D., Nilsson,J., Davey,N.E. and Ivarsson,Y.
  TITLE     Large-scale phosphomimetic screening identifies phospho-modulated
            motif-based protein interactions
  JOURNAL   Mol Syst Biol 19 (7), e11164 (2023)
   PUBMED   37219487
REFERENCE   3  (residues 1 to 699)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   4  (residues 1 to 699)
  AUTHORS   Benz,C., Ali,M., Krystkowiak,I., Simonetti,L., Sayadi,A.,
            Mihalic,F., Kliche,J., Andersson,E., Jemth,P., Davey,N.E. and
            Ivarsson,Y.
  TITLE     Proteome-scale mapping of binding sites in the unstructured regions
            of the human proteome
  JOURNAL   Mol Syst Biol 18 (1), e10584 (2022)
   PUBMED   35044719
REFERENCE   5  (residues 1 to 699)
  AUTHORS   Xu,C., Wu,J., Wu,Y., Ren,Z., Yao,Y., Chen,G., Fang,E.F., Noh,J.H.,
            Liu,Y.U., Wei,L., Chen,X. and Sima,J.
  TITLE     TNF-alpha-dependent neuronal necroptosis regulated in Alzheimer's
            disease by coordination of RIPK1-p62 complex with autophagic UVRAG
  JOURNAL   Theranostics 11 (19), 9452-9469 (2021)
   PUBMED   34646380
  REMARK    GeneRIF: TNF-alpha-dependent neuronal necroptosis regulated in
            Alzheimer's disease by coordination of RIPK1-p62 complex with
            autophagic UVRAG.
            Publication Status: Online-Only
REFERENCE   6  (residues 1 to 699)
  AUTHORS   Iida,A., Emi,M., Matsuoka,R., Hiratsuka,E., Okui,K., Ohashi,H.,
            Inazawa,J., Fukushima,Y., Imai,T. and Nakamura,Y.
  TITLE     Identification of a gene disrupted by inv(11)(q13.5;q25) in a
            patient with left-right axis malformation
  JOURNAL   Hum Genet 106 (3), 277-287 (2000)
   PUBMED   10798355
REFERENCE   7  (residues 1 to 699)
  AUTHORS   Perelman,B., Dafni,N., Naiman,T., Eli,D., Yaakov,M., Feng,T.L.,
            Sinha,S., Weber,G., Khodaei,S., Sancar,A., Dotan,I. and Canaani,D.
  TITLE     Molecular cloning of a novel human gene encoding a 63-kDa protein
            and its sublocalization within the 11q13 locus
  JOURNAL   Genomics 41 (3), 397-405 (1997)
   PUBMED   9169138
REFERENCE   8  (residues 1 to 699)
  AUTHORS   Panaretou,C., Domin,J., Cockcroft,S. and Waterfield,M.D.
  TITLE     Characterization of p150, an adaptor protein for the human
            phosphatidylinositol (PtdIns) 3-kinase. Substrate presentation by
            phosphatidylinositol transfer protein to the p150.Ptdins 3-kinase
            complex
  JOURNAL   J Biol Chem 272 (4), 2477-2485 (1997)
   PUBMED   8999962
REFERENCE   9  (residues 1 to 699)
  AUTHORS   Bekri,S., Adelaide,J., Merscher,S., Grosgeorge,J., Caroli-Bosc,F.,
            Perucca-Lostanlen,D., Kelley,P.M., Pebusque,M.J., Theillet,C.,
            Birnbaum,D. and Gaudray,P.
  TITLE     Detailed map of a region commonly amplified at 11q13-->q14 in human
            breast carcinoma
  JOURNAL   Cytogenet Cell Genet 79 (1-2), 125-131 (1997)
   PUBMED   9533029
REFERENCE   10 (residues 1 to 699)
  AUTHORS   Teitz,T., Penner,M., Eli,D., Stark,M., Bakhanashvili,M., Naiman,T.
            and Canaani,D.
  TITLE     Isolation by polymerase chain reaction of a cDNA whose product
            partially complements the ultraviolet sensitivity of xeroderma
            pigmentosum group C cells
  JOURNAL   Gene 87 (2), 295-298 (1990)
   PUBMED   2332174
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DB087351.1, AB012958.1 and
            AP002340.3.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Jul 3, 2002 this sequence version replaced NP_003360.1.
            
            Summary: This gene complements the ultraviolet sensitivity of
            xeroderma pigmentosum group C cells and encodes a protein with a C2
            domain. The protein activates the Beclin1-PI(3)KC3 complex,
            promoting autophagy and suppressing the proliferation and
            tumorigenicity of human colon cancer cells. Chromosomal aberrations
            involving this gene are associated with left-right axis
            malformation and mutations in this gene have been associated with
            colon cancer. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660807.160384.1,
                                           SRR1660805.180317.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000356136.8/ ENSP00000348455.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..699
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q13.5"
     Protein         1..699
                     /product="UV radiation resistance-associated gene protein
                     isoform 2"
                     /note="beclin 1 binding protein; disrupted in heterotaxy;
                     UV radiation resistance-associated gene protein"
                     /calculated_mol_wt=78020
     Region          1..24
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9P2Y5.1)"
     Region          39..437
                     /region_name="VPS38"
                     /note="Vacuolar protein sorting 38; pfam17649"
                     /db_xref="CDD:435943"
     Region          200..269
                     /region_name="Sufficient for interaction with STX7, VTI1B
                     AND STX8. /evidence=ECO:0000269|PubMed:24550300"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9P2Y5.1)"
     Region          270..442
                     /region_name="Sufficient for interaction with VPS16,
                     required for interaction with CEP63.
                     /evidence=ECO:0000269|PubMed:18552835,
                     ECO:0000269|PubMed:22542840"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9P2Y5.1)"
     Region          443..699
                     /region_name="Required for interaction with PRKDC, XRCC6
                     and XRCC5. /evidence=ECO:0000269|PubMed:22542840"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9P2Y5.1)"
     Region          486..591
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9P2Y5.1)"
     Site            493
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000269|PubMed:25533187; propagated from
                     UniProtKB/Swiss-Prot (Q9P2Y5.1)"
     Site            498
                     /site_type="phosphorylation"
                     /note="Phosphoserine, by MTOR.
                     /evidence=ECO:0000269|PubMed:25533187,
                     ECO:0007744|PubMed:18691976, ECO:0007744|PubMed:19369195,
                     ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:23186163;
                     propagated from UniProtKB/Swiss-Prot (Q9P2Y5.1)"
     Site            508
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000269|PubMed:25533187; propagated from
                     UniProtKB/Swiss-Prot (Q9P2Y5.1)"
     Site            518
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0007744|PubMed:18669648,
                     ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:23186163;
                     propagated from UniProtKB/Swiss-Prot (Q9P2Y5.1)"
     Site            522
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000269|PubMed:25533187; propagated from
                     UniProtKB/Swiss-Prot (Q9P2Y5.1)"
     Site            549
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000269|PubMed:25533187; propagated from
                     UniProtKB/Swiss-Prot (Q9P2Y5.1)"
     Site            550
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000269|PubMed:25533187,
                     ECO:0007744|PubMed:23186163; propagated from
                     UniProtKB/Swiss-Prot (Q9P2Y5.1)"
     Site            571
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:19369195; propagated from
                     UniProtKB/Swiss-Prot (Q9P2Y5.1)"
     Site            582
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000269|PubMed:25533187; propagated from
                     UniProtKB/Swiss-Prot (Q9P2Y5.1)"
     Site            689
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:23186163; propagated from
                     UniProtKB/Swiss-Prot (Q9P2Y5.1)"
     CDS             1..699
                     /gene="UVRAG"
                     /gene_synonym="DHTX; p63; VPS38"
                     /coded_by="NM_003369.4:199..2298"
                     /note="isoform 2 is encoded by transcript variant 2"
                     /db_xref="CCDS:CCDS8241.1"
                     /db_xref="GeneID:7405"
                     /db_xref="HGNC:HGNC:12640"
                     /db_xref="MIM:602493"
ORIGIN      
        1 msasasvggp vpqpppgpaa alppgsaara lhvelpsqqr rlrhlrniaa rnivnrnghq
       61 lldtyftlhl cstekiykef yrseviknsl nptwrsldfg impdrldtsv scfvvkiwgg
      121 keniyqllie wkvcldglky lgqqiharnq neiifglndg yygapfehkg ysnaqktill
      181 qvdqncvrns ydvfsllrlh raqcaikqtq vtvqkigkei eeklrltsts nelkkksecl
      241 qlkilvlqne lerqkkalgr evallhkqqi alqdkgsafs aehlklqlqk eslnelrkec
      301 takrelflkt naqltircrq llselsyiyp idlnehkdyf vcgvklpnse dfqakddgsi
      361 avalgytahl vsmisfflqv plrypiihkg srstikdnin dkltekeref plypkggekl
      421 qfdygvylln kniaqlryqh glgtpdlrqt lpnlknfmeh glmvrcdrhh tssaipvpkr
      481 qssifggadv gfsggipspd kghrkrasse nerlqyktpp psynsalaqp vttvpsmget
      541 erkitslsss ldtsldfske nkkkgedlvg slngghanvh psqeqgeals ghratvngtl
      601 lpseqagsas vqlpgefhpv seaelcctve qaeeiiglea tgfasgdqle afncipvdsa
      661 vavecdeqvl gefeefsrri yalnenvssf rrprrssdk
//
