LOCUS       NM_001258249            6174 bp    mRNA    linear   PRI 12-JUN-2024
DEFINITION  Homo sapiens ubiquitously transcribed tetratricopeptide repeat
            containing, Y-linked (UTY), transcript variant 4, mRNA.
ACCESSION   NM_001258249
VERSION     NM_001258249.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6174)
  AUTHORS   Cunningham,C.M., Li,M., Ruffenach,G., Doshi,M., Aryan,L., Hong,J.,
            Park,J., Hrncir,H., Medzikovic,L., Umar,S., Arnold,A.P. and
            Eghbali,M.
  TITLE     Y-Chromosome Gene, Uty, Protects Against Pulmonary Hypertension by
            Reducing Proinflammatory Chemokines
  JOURNAL   Am J Respir Crit Care Med 206 (2), 186-196 (2022)
   PUBMED   35504005
  REMARK    GeneRIF: Y-Chromosome Gene, Uty, Protects Against Pulmonary
            Hypertension by Reducing Proinflammatory Chemokines.
REFERENCE   2  (bases 1 to 6174)
  AUTHORS   Pottmeier,P., Doszyn,O., Peuckert,C. and Jazin,E.
  TITLE     Increased Expression of Y-Encoded Demethylases During
            Differentiation of Human Male Neural Stem Cells
  JOURNAL   Stem Cells Dev 29 (23), 1497-1509 (2020)
   PUBMED   33040644
  REMARK    GeneRIF: Increased Expression of Y-Encoded Demethylases During
            Differentiation of Human Male Neural Stem Cells.
REFERENCE   3  (bases 1 to 6174)
  AUTHORS   Tricarico,R., Nicolas,E., Hall,M.J. and Golemis,E.A.
  TITLE     X- and Y-Linked Chromatin-Modifying Genes as Regulators of
            Sex-Specific Cancer Incidence and Prognosis
  JOURNAL   Clin Cancer Res 26 (21), 5567-5578 (2020)
   PUBMED   32732223
  REMARK    GeneRIF: X- and Y-Linked Chromatin-Modifying Genes as Regulators of
            Sex-Specific Cancer Incidence and Prognosis.
            Review article
REFERENCE   4  (bases 1 to 6174)
  AUTHORS   Fan,Z., Zhao,W., Fan,S., Li,C., Qiao,J. and Xu,Y.
  TITLE     Identification of Potential Biomarkers for Intervertebral Disc
            Degeneration Using the Genome-Wide Expression Analysis
  JOURNAL   J Comput Biol 27 (9), 1341-1349 (2020)
   PUBMED   31904996
  REMARK    GeneRIF: Identification of Potential Biomarkers for Intervertebral
            Disc Degeneration Using the Genome-Wide Expression Analysis.
REFERENCE   5  (bases 1 to 6174)
  AUTHORS   Gazova,I., Lengeling,A. and Summers,K.M.
  TITLE     Lysine demethylases KDM6A and UTY: The X and Y of histone
            demethylation
  JOURNAL   Mol Genet Metab 127 (1), 31-44 (2019)
   PUBMED   31097364
  REMARK    GeneRIF: UTY is co-regulated with KDM6A. UTY compensates for KDM6A
            in eutherian males and is responsible for the association between
            the loss of the Y chromosome and poor prognosis in a range of
            cancers. [review]
            Review article
REFERENCE   6  (bases 1 to 6174)
  AUTHORS   Laaser,I., Theis,F.J., de Angelis,M.H., Kolb,H.J. and Adamski,J.
  TITLE     Huge splicing frequency in human Y chromosomal UTY gene
  JOURNAL   OMICS 15 (3), 141-154 (2011)
   PUBMED   21329462
REFERENCE   7  (bases 1 to 6174)
  AUTHORS   Warren,E.H., Gavin,M.A., Simpson,E., Chandler,P., Page,D.C.,
            Disteche,C., Stankey,K.A., Greenberg,P.D. and Riddell,S.R.
  TITLE     The human UTY gene encodes a novel HLA-B8-restricted H-Y antigen
  JOURNAL   J Immunol 164 (5), 2807-2814 (2000)
   PUBMED   10679124
REFERENCE   8  (bases 1 to 6174)
  AUTHORS   Grbavec,D., Lo,R., Liu,Y., Greenfield,A. and Stifani,S.
  TITLE     Groucho/transducin-like enhancer of split (TLE) family members
            interact with the yeast transcriptional co-repressor SSN6 and
            mammalian SSN6-related proteins: implications for evolutionary
            conservation of transcription repression mechanisms
  JOURNAL   Biochem J 337 (Pt 1) (Pt 1), 13-17 (1999)
   PUBMED   9854018
REFERENCE   9  (bases 1 to 6174)
  AUTHORS   Greenfield,A., Carrel,L., Pennisi,D., Philippe,C., Quaderi,N.,
            Siggers,P., Steiner,K., Tam,P.P., Monaco,A.P., Willard,H.F. and
            Koopman,P.
  TITLE     The UTX gene escapes X inactivation in mice and humans
  JOURNAL   Hum Mol Genet 7 (4), 737-742 (1998)
   PUBMED   9499428
REFERENCE   10 (bases 1 to 6174)
  AUTHORS   Lahn,B.T. and Page,D.C.
  TITLE     Functional coherence of the human Y chromosome
  JOURNAL   Science 278 (5338), 675-680 (1997)
   PUBMED   9381176
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC006376.2 and AC010877.3.
            
            On Oct 19, 2020 this sequence version replaced NM_001258249.1.
            
            Summary: This gene encodes a protein containing tetratricopeptide
            repeats which are thought to be involved in protein-protein
            interactions. The encoded protein is also a minor
            histocompatibility antigen which may induce graft rejection of male
            stem cell grafts. A large number of alternatively spliced
            transcripts have been observed for this gene, but the full length
            nature of some of these variants has not been determined. [provided
            by RefSeq, Apr 2012].
            
            Transcript Variant: This variant (4) encodes the longest isoform
            (4).
            
            Sequence Note: This RefSeq record was created based on a transcript
            variant reported in PMID: 21329462, and assembled from transcript
            and genomic sequence data to make the sequence consistent with the
            reference genome assembly.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: EF612668.1, SRR18074967.119551.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000545955.6/ ENSP00000442047.2
            RefSeq Select criteria :: based on manual assertion
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-520               AC006376.2         148617-149136       c
            521-584             AC006376.2         148357-148420       c
            585-693             AC006376.2         139224-139332       c
            694-743             AC006376.2         118120-118169       c
            744-802             AC006376.2         83838-83896         c
            803-923             AC006376.2         80096-80216         c
            924-978             AC006376.2         66021-66075         c
            979-1013            AC006376.2         62962-62996         c
            1014-1107           AC006376.2         38359-38452         c
            1108-1234           AC006376.2         35370-35496         c
            1235-1333           AC006376.2         29533-29631         c
            1334-1553           AC006376.2         28870-29089         c
            1554-1688           AC006376.2         28191-28325         c
            1689-1844           AC006376.2         27567-27722         c
            1845-1937           AC006376.2         26980-27072         c
            1938-2033           AC006376.2         25026-25121         c
            2034-2429           AC006376.2         24106-24501         c
            2430-3202           AC006376.2         4666-5438           c
            3203-3332           AC010877.3         132353-132482       c
            3333-3438           AC010877.3         130733-130838       c
            3439-3644           AC010877.3         129687-129892       c
            3645-3709           AC010877.3         112318-112382       c
            3710-3784           AC010877.3         112170-112244       c
            3785-3933           AC010877.3         111531-111679       c
            3934-4048           AC010877.3         109009-109123       c
            4049-4236           AC010877.3         105089-105276       c
            4237-4378           AC010877.3         103839-103980       c
            4379-4505           AC010877.3         66410-66536         c
            4506-4676           AC010877.3         57149-57319         c
            4677-6174           AC010877.3         54517-56014         c
FEATURES             Location/Qualifiers
     source          1..6174
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="Y"
                     /map="Yq11.221"
     gene            1..6174
                     /gene="UTY"
                     /gene_synonym="KDM6AL; KDM6C; UTY1"
                     /note="ubiquitously transcribed tetratricopeptide repeat
                     containing, Y-linked"
                     /db_xref="GeneID:7404"
                     /db_xref="HGNC:HGNC:12638"
                     /db_xref="MIM:400009"
     exon            1..520
                     /gene="UTY"
                     /gene_synonym="KDM6AL; KDM6C; UTY1"
                     /inference="alignment:Splign:2.1.0"
     CDS             369..4703
                     /gene="UTY"
                     /gene_synonym="KDM6AL; KDM6C; UTY1"
                     /EC_number="1.14.11.68"
                     /note="isoform 4 is encoded by transcript variant 4;
                     ubiquitously transcribed tetratricopeptide repeat gene, Y
                     chromosome; ubiquitously transcribed TPR gene on Y
                     chromosome; histone demethylase UTY; [histone
                     H3]-trimethyl-L-lysine(27) demethylase UTY; ubiquitous TPR
                     motif protein UTY; ubiquitously-transcribed TPR protein on
                     the Y chromosome; ubiquitously-transcribed Y chromosome
                     tetratricopeptide repeat protein; ubiquitously transcribed
                     tetratricopeptide repeat gene, Y-linked"
                     /codon_start=1
                     /product="histone demethylase UTY isoform 4"
                     /protein_id="NP_001245178.1"
                     /db_xref="CCDS:CCDS76079.1"
                     /db_xref="GeneID:7404"
                     /db_xref="HGNC:HGNC:12638"
                     /db_xref="MIM:400009"
                     /translation="MKSCAVSLTTAAVAFGDEAKKMAEGKASRESEEESVSLTVEERE
                     ALGGMDSRLFGFVRLHEDGARTKTLLGKAVRCYESLILKAEGKVESDFFCQLGHFNLL
                     LEDYSKALSAYQRYYSLQADYWKNAAFLYGLGLVYFYYNAFHWAIKAFQDVLYVDPSF
                     CRAKEIHLRLGLMFKVNTDYKSSLKHFQLALIDCNPCTLSNAEIQFHIAHLYETQRKY
                     HSAKEAYEQLLQTENLPAQVKATVLQQLGWMHHNMDLVGDKATKESYAIQYLQKSLEA
                     DPNSGQSWYFLGRCYSSIGKVQDAFISYRQSIDKSEASADTWCSIGVLYQQQNQPMDA
                     LQAYICAVQLDHGHAAAWMDLGTLYESCNQPQDAIKCYLNAARSKRCSNTSTLAARIK
                     FLQAQLCNLPQSSLQNKTKLLPSIEEAWSLPIPAELTSRQGAMNTAQQAYRAHDPNTE
                     HVLNHSQTPILQQSLSLHMITSSQVEGLSSPAKKKRTSSPTKNGSDNWNGGQSLSHHP
                     VQQVYSLCLTPQKLQHLEQLRANRDNLNPAQKHQLEQLESQFVLMQQMRHKEVAQVRT
                     TGIHNGAITDSSLPTNSVSNRQPHGALTRVSSVSQPGVRPACVEKLLSSGAFSAGCIP
                     CGTSKILGSTDTILLGSNCIAGSESNGNVPYLQQNTHTLPHNHTDLNSSTEEPWRKQL
                     SNSAQGLHKSQSSCLSGPNEEQPLFSTGSAQYHQATSTGIKKANEHLTLPSNSVPQGD
                     ADSHLSCHTATSGGQQGIMFTKESKPSKNRSLVPETSRHTGDTSNGCADVKGLSNHVH
                     QLIADAVSSPNHGDSPNLLIADNPQLSALLIGKANGNVGTGTCDKVNNIHPAVHTKTD
                     HSVASSPSSAISTATPSPKSTEQRSINSVTSLNSPHSGLHTVNGEGLGKSQSSTKVDL
                     PLASHRSTSQILPSMSVSICPSSTEVLKACRNPGKNGLSNSCILLDKCPPPRPPTSPY
                     PPLPKDKLNPPTPSIYLENKRDAFFPPLHQFCTNPKNPVTVIRGLAGALKLDLGLFST
                     KTLVEANNEHMVEVRTQLLQPADENWDPTGTKKIWRCESNRSHTTIAKYAQYQASSFQ
                     ESLREENEKRTQHKDHSDNESTSSENSGRRRKGPFKTIKFGTNIDLSDNKKWKLQLHE
                     LTKLPAFARVVSAGNLLTHVGHTILGMNTVQLYMKVPGSRTPGHQENNNFCSVNINIG
                     PGDCEWFVVPEDYWGVLNDFCEKNNLNFLMSSWWPNLEDLYEANVPVYRFIQRPGDLV
                     WINAGTVHWVQAVGWCNNIAWNVGPLTACQYKLAVERYEWNKLKSVKSPVPMVHLSWN
                     MARNIKVSDPKLFEMIKYCLLKILKQYQTLREALVAAGKEVIWHGRTNDEPAHYCSIC
                     EVEVFNLLFVTNESNTQKTYIVHCHDCARKTSKSLENFVVLEQYKMEDLIQVYDQFTL
                     ALSLSSSS"
     exon            521..584
                     /gene="UTY"
                     /gene_synonym="KDM6AL; KDM6C; UTY1"
                     /inference="alignment:Splign:2.1.0"
     exon            585..693
                     /gene="UTY"
                     /gene_synonym="KDM6AL; KDM6C; UTY1"
                     /inference="alignment:Splign:2.1.0"
     exon            694..743
                     /gene="UTY"
                     /gene_synonym="KDM6AL; KDM6C; UTY1"
                     /inference="alignment:Splign:2.1.0"
     exon            744..802
                     /gene="UTY"
                     /gene_synonym="KDM6AL; KDM6C; UTY1"
                     /inference="alignment:Splign:2.1.0"
     exon            803..923
                     /gene="UTY"
                     /gene_synonym="KDM6AL; KDM6C; UTY1"
                     /inference="alignment:Splign:2.1.0"
     exon            924..978
                     /gene="UTY"
                     /gene_synonym="KDM6AL; KDM6C; UTY1"
                     /inference="alignment:Splign:2.1.0"
     exon            979..1013
                     /gene="UTY"
                     /gene_synonym="KDM6AL; KDM6C; UTY1"
                     /inference="alignment:Splign:2.1.0"
     exon            1014..1107
                     /gene="UTY"
                     /gene_synonym="KDM6AL; KDM6C; UTY1"
                     /inference="alignment:Splign:2.1.0"
     exon            1108..1234
                     /gene="UTY"
                     /gene_synonym="KDM6AL; KDM6C; UTY1"
                     /inference="alignment:Splign:2.1.0"
     exon            1235..1333
                     /gene="UTY"
                     /gene_synonym="KDM6AL; KDM6C; UTY1"
                     /inference="alignment:Splign:2.1.0"
     exon            1334..1553
                     /gene="UTY"
                     /gene_synonym="KDM6AL; KDM6C; UTY1"
                     /inference="alignment:Splign:2.1.0"
     exon            1554..1688
                     /gene="UTY"
                     /gene_synonym="KDM6AL; KDM6C; UTY1"
                     /inference="alignment:Splign:2.1.0"
     exon            1689..1844
                     /gene="UTY"
                     /gene_synonym="KDM6AL; KDM6C; UTY1"
                     /inference="alignment:Splign:2.1.0"
     exon            1845..1937
                     /gene="UTY"
                     /gene_synonym="KDM6AL; KDM6C; UTY1"
                     /inference="alignment:Splign:2.1.0"
     exon            1938..2033
                     /gene="UTY"
                     /gene_synonym="KDM6AL; KDM6C; UTY1"
                     /inference="alignment:Splign:2.1.0"
     exon            2034..2429
                     /gene="UTY"
                     /gene_synonym="KDM6AL; KDM6C; UTY1"
                     /inference="alignment:Splign:2.1.0"
     exon            2430..3202
                     /gene="UTY"
                     /gene_synonym="KDM6AL; KDM6C; UTY1"
                     /inference="alignment:Splign:2.1.0"
     exon            3203..3332
                     /gene="UTY"
                     /gene_synonym="KDM6AL; KDM6C; UTY1"
                     /inference="alignment:Splign:2.1.0"
     exon            3333..3438
                     /gene="UTY"
                     /gene_synonym="KDM6AL; KDM6C; UTY1"
                     /inference="alignment:Splign:2.1.0"
     exon            3439..3644
                     /gene="UTY"
                     /gene_synonym="KDM6AL; KDM6C; UTY1"
                     /inference="alignment:Splign:2.1.0"
     exon            3645..3709
                     /gene="UTY"
                     /gene_synonym="KDM6AL; KDM6C; UTY1"
                     /inference="alignment:Splign:2.1.0"
     exon            3710..3784
                     /gene="UTY"
                     /gene_synonym="KDM6AL; KDM6C; UTY1"
                     /inference="alignment:Splign:2.1.0"
     exon            3785..3933
                     /gene="UTY"
                     /gene_synonym="KDM6AL; KDM6C; UTY1"
                     /inference="alignment:Splign:2.1.0"
     exon            3934..4048
                     /gene="UTY"
                     /gene_synonym="KDM6AL; KDM6C; UTY1"
                     /inference="alignment:Splign:2.1.0"
     exon            4049..4236
                     /gene="UTY"
                     /gene_synonym="KDM6AL; KDM6C; UTY1"
                     /inference="alignment:Splign:2.1.0"
     exon            4237..4378
                     /gene="UTY"
                     /gene_synonym="KDM6AL; KDM6C; UTY1"
                     /inference="alignment:Splign:2.1.0"
     exon            4379..4505
                     /gene="UTY"
                     /gene_synonym="KDM6AL; KDM6C; UTY1"
                     /inference="alignment:Splign:2.1.0"
     exon            4506..4676
                     /gene="UTY"
                     /gene_synonym="KDM6AL; KDM6C; UTY1"
                     /inference="alignment:Splign:2.1.0"
     exon            4677..6174
                     /gene="UTY"
                     /gene_synonym="KDM6AL; KDM6C; UTY1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6099..6104
                     /regulatory_class="polyA_signal_sequence"
                     /gene="UTY"
                     /gene_synonym="KDM6AL; KDM6C; UTY1"
                     /note="hexamer: ATTAAA"
     polyA_site      6125
                     /gene="UTY"
                     /gene_synonym="KDM6AL; KDM6C; UTY1"
                     /note="major polyA site"
     regulatory      6155..6160
                     /regulatory_class="polyA_signal_sequence"
                     /gene="UTY"
                     /gene_synonym="KDM6AL; KDM6C; UTY1"
                     /note="hexamer: AATAAT"
     polyA_site      6174
                     /gene="UTY"
                     /gene_synonym="KDM6AL; KDM6C; UTY1"
ORIGIN      
        1 agtcgcctag attggctaca actaagtggt tgggagcggg gaggtcgcgg cggctgcgtg
       61 gggttcgccc gtgacacaat tacaactttg tgctggtgct ggcaaagttt gtgattttaa
      121 gaaattctgc tgtgctctcc agcactgcga gcttctgcct tccctgtagt ttcccagatg
      181 tgatccaggt agccgagttc cgctgcccgt gcttcggtag cttaagtctt tgcctcagct
      241 tttttccttg cagccgctga ggaggcgata aaattggcgt cacagtctca agcagcgatt
      301 gaaggcgtct tttcaactac tcgattaagg ttgggtatcg tcgtgggact tggaaatttg
      361 ttgtttccat gaaatcctgc gcagtgtcgc tcactaccgc cgctgttgcc ttcggtgatg
      421 aggcaaagaa aatggcggaa ggaaaagcga gccgcgagag tgaagaggag tctgttagcc
      481 tgacagtcga ggaaagggag gcgcttggtg gcatggacag ccgtctcttc gggttcgtga
      541 ggcttcatga agatggcgcc agaacgaaga ccctactagg caaggctgtt cgctgctacg
      601 aatctttaat cttaaaagct gaaggaaaag tggagtctga cttcttttgc caattaggtc
      661 acttcaacct cttgttggaa gattattcaa aagcattatc tgcatatcag agatattaca
      721 gtttacaggc tgactactgg aagaatgctg cgtttttata tggccttggt ttggtctact
      781 tctactacaa tgcatttcat tgggcaatta aagcatttca agatgtcctt tatgttgacc
      841 ccagcttttg tcgagccaag gaaattcatt tacgacttgg gctcatgttc aaagtgaaca
      901 cagactacaa gtctagttta aagcattttc agttagcctt gattgactgt aatccatgta
      961 ctttgtccaa tgctgaaatt caatttcata ttgcccattt gtatgaaacc cagaggaagt
     1021 atcattctgc aaaggaggca tatgaacaac ttttgcagac agaaaacctt cctgcacaag
     1081 taaaagcaac tgtattgcaa cagttaggtt ggatgcatca taatatggat ctagtaggag
     1141 acaaagccac aaaggaaagc tatgctattc agtatctcca aaagtctttg gaggcagatc
     1201 ctaattctgg ccaatcgtgg tattttcttg gaaggtgtta ttcaagtatt gggaaagttc
     1261 aggatgcctt tatatcttac aggcaatcta ttgataaatc agaagcaagt gcagatacat
     1321 ggtgttcaat aggtgtgttg tatcagcagc aaaatcagcc tatggatgct ttacaggcat
     1381 atatttgtgc tgtacaattg gaccatgggc atgccgcagc ctggatggac ctaggtactc
     1441 tctatgaatc ctgcaatcaa cctcaagatg ccattaaatg ctacctaaat gcagctagaa
     1501 gcaaacgttg tagtaatacc tctacgcttg ctgcaagaat taaatttcta caggctcagt
     1561 tgtgtaacct tccacaaagt agtctacaga ataaaactaa attacttcct agtattgagg
     1621 aggcatggag cctaccaatc cccgcagagc ttacctccag gcagggtgcc atgaacacag
     1681 cacagcaggc ttatagagct catgatccaa atactgaaca tgtattaaac cacagtcaaa
     1741 caccaatttt acagcaatcc ttgtcactac acatgattac ttctagccaa gtagaaggcc
     1801 tgtccagtcc tgccaagaag aaaagaacat ctagtccaac aaagaatggt tctgataact
     1861 ggaatggtgg ccagagtctt tcacatcatc cagtacagca agtttattcg ttgtgtttga
     1921 caccacagaa attacagcac ttggaacaac tgcgagcaaa tagagataat ttaaatccag
     1981 cacagaagca tcagctggaa cagttagaaa gtcagtttgt cttaatgcag caaatgagac
     2041 acaaagaagt tgctcaggta cgaactactg gaattcataa cggggccata actgattcat
     2101 cactgcctac aaactctgtc tctaatcgac aaccacatgg tgctctgacc agagtatcta
     2161 gcgtctctca gcctggagtt cgccctgctt gtgttgaaaa acttttgtcc agtggagctt
     2221 tttctgcagg ctgtattcct tgtggcacat caaaaattct aggaagtaca gacactatct
     2281 tgctaggcag taattgtata gcaggaagtg aaagtaatgg aaatgtgcct tacctgcagc
     2341 aaaatacaca cactctacct cataatcata cagacctgaa cagcagcaca gaagagccat
     2401 ggagaaaaca gctatctaac tccgctcagg ggcttcataa aagtcagagt tcatgtttgt
     2461 caggacctaa tgaagaacaa cctctgtttt ccactgggtc agcccagtat caccaggcaa
     2521 ctagcactgg tattaagaag gcgaatgaac atctcactct gcctagtaat tcagtaccac
     2581 agggggatgc tgacagtcac ctctcctgtc atactgctac ctcaggtgga caacaaggca
     2641 ttatgtttac caaagagagc aagccttcaa aaaatagatc cttggtgcct gaaacaagca
     2701 ggcatactgg agacacatct aatggctgtg ctgatgtcaa gggactttct aatcatgttc
     2761 atcagttgat agcagatgct gtttccagtc ctaaccatgg agattcacca aatttattaa
     2821 ttgcagacaa tcctcagctc tctgctttgt tgattggaaa agccaatggc aatgtgggta
     2881 ctggaacctg tgacaaagtg aataatattc acccagctgt tcatacaaag actgatcatt
     2941 ctgttgcctc ttcaccctct tcagccattt ccacagcaac accttctcct aaatccactg
     3001 agcagagaag cataaacagt gttaccagcc ttaacagtcc tcacagtgga ttacacacag
     3061 tcaatggaga ggggctgggg aagtcacaga gctctacaaa agtagacctg cctttagcta
     3121 gccacagatc tacttctcag atcttaccat caatgtcagt gtctatatgc cccagttcaa
     3181 cagaagttct gaaagcatgc aggaatccag gtaaaaatgg cttgtctaat agctgcattt
     3241 tgttagataa atgtccacct ccaagaccac caacttcacc atacccaccc ttgccaaagg
     3301 acaagttgaa tccacccaca cctagtattt acttggaaaa taaacgtgat gctttctttc
     3361 ctccattaca tcaattttgt acaaatccaa aaaaccctgt tacagtaata cgtggccttg
     3421 ctggagctct taaattagat cttggacttt tctctaccaa aactttggta gaagctaaca
     3481 atgaacatat ggtagaagtg aggacacagt tgctgcaacc agcagatgaa aactgggatc
     3541 ccactggaac aaagaaaatc tggcgttgtg aaagcaatag atctcatact acaattgcca
     3601 aatacgcaca ataccaggct tcctccttcc aggaatcatt gagagaagaa aatgagaaaa
     3661 gaacacaaca caaagatcat tcagataacg aatccacatc ttcagagaat tctggaagga
     3721 gaaggaaagg accttttaaa accataaaat ttgggaccaa cattgacctc tctgataaca
     3781 aaaagtggaa gttgcagtta catgaactga ctaaacttcc tgcttttgcg cgtgtggtgt
     3841 cagcaggaaa tcttctaacc catgttgggc ataccattct gggcatgaat acagtacaac
     3901 tgtatatgaa agttccaggg agtcggacac caggtcacca agaaaataac aacttctgct
     3961 ctgttaacat aaatattggt ccaggagatt gtgaatggtt tgttgtacct gaagattatt
     4021 ggggtgttct gaatgacttc tgtgaaaaaa ataatttgaa ttttttaatg agttcttggt
     4081 ggcccaacct tgaagatctt tatgaagcaa atgtccctgt gtatagattt attcagcgac
     4141 ctggagattt ggtctggata aatgcaggca ctgtgcattg ggttcaagct gttggctggt
     4201 gcaataacat tgcctggaat gttggtccac ttacagcctg ccagtataaa ttggcagtgg
     4261 aacggtatga atggaacaaa ttgaaaagtg tgaagtcacc agtacccatg gtgcatcttt
     4321 cctggaatat ggcacgaaat atcaaagtct cagatccaaa gctttttgaa atgattaagt
     4381 attgtctttt gaaaattctg aagcaatatc agacattgag agaagctctt gttgcagcag
     4441 gaaaagaggt tatatggcat gggcggacaa atgatgaacc agctcattac tgtagcattt
     4501 gtgaggtgga ggtttttaat ctgctttttg tcactaatga aagcaatact caaaaaacct
     4561 acatagtaca ttgccatgat tgtgcacgaa aaacaagcaa aagtttggaa aattttgtgg
     4621 tgctcgaaca gtacaaaatg gaggacctaa tccaagttta tgatcaattt acactagctc
     4681 tttcattatc atcctcatct tgatatagtt ccatgaatat taaatgagat tatttctgct
     4741 cttcaggaaa tttctgcacc actggttttg tagctgtttc ataaaactgt tgactaaaag
     4801 ctatgtctat gcaaccttcc aagaatagta tgtcaagcaa ctggacacag tgctgcctct
     4861 gcttcaggac ttaacatgct gatccagctg tacttcagaa aaataatatt aatcatatgt
     4921 tttgtgtacg tatgacaaac tgtcaaagtg acacagaata ctgatttgaa gatagccttt
     4981 tttatgtttc tctatttctg ggctgatgaa ttaatattca tttgtatttt aaccctgcag
     5041 aattttcctt agttaaaaac actttcctag ctggtcattt cttcataaga tagcaaattt
     5101 aaatctctcc tcgatcagct tttaaaaaat gtgtactatt atctgaggaa gttttttact
     5161 gctttatgtt tttgtgtgtt ttgaggccat gatgattaca tttgtggttc caaaataatt
     5221 tttttaaata ttaatagccc atatacaaag ataatggatt gcacatagac aaagaaataa
     5281 acttcagatt tgtgattttt gtttctaaac ttgatacaga tttacactat ttataaatac
     5341 gtatttattg cctgaaaata tttgtgaatg gaatgttgtt tttttccaga cgtaactgcc
     5401 attaaatact aaggagttct gtagttttaa acactactcc tattacattt tatatgtgta
     5461 gataaaactg cttagtatta tacagaaatt tttattaaaa ttgttaaatg tttaaagggt
     5521 ttcccaatgt ttgagtttaa aaaagacttt ctgaaaaaat ccactttttg ttcattttca
     5581 aacctaatga ttatatgtat tttatatgtg tgtgtatgtg tacacacatg tataatatat
     5641 acagaaacct cgatatataa ttgtatagat tttaaaagtt ttatttttta catctatggt
     5701 agtttttgag gtgcctatta taaagtatta cggaagtttg ctgtttttaa agtaaatgtc
     5761 ttttagtgtg atttattaag ttgtagtcac catagtgata gcccataaat aattgctgga
     5821 aaattgtatt ttataacagt agaaaacata tagtcagtga agtaaatatt ttaaaggaaa
     5881 cattatatag atttgataaa tgttgtttat aattaagagt ttcttatgga aaagagattc
     5941 agaatgataa cctcttttag agaacaaata agtgacttat ttttttaaag ctagatgact
     6001 ttgaaatgct atactgtcct gcttgtacaa catggtttgg ggtgaagggg aggaaagtat
     6061 taaaaaatct atatcgctag taaattgtaa taagttctat taaaacttgt atttcatatg
     6121 aaaaatttgc taatttaata ttaactcatt tgataataat acttgtcttt tcta
//
