LOCUS       NM_018949               3685 bp    mRNA    linear   PRI 09-JUN-2024
DEFINITION  Homo sapiens urotensin 2 receptor (UTS2R), transcript variant 1,
            mRNA.
ACCESSION   NM_018949
VERSION     NM_018949.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3685)
  AUTHORS   Nassour,H., Hoang,T.A., Martin,R.D., Dallagnol,J.C.C., Billard,E.,
            Letourneau,M., Novellino,E., Carotenuto,A., Allen,B.G., Tanny,J.C.,
            Fournier,A., Hebert,T.E. and Chatenet,D.
  TITLE     Lipidated peptides derived from intracellular loops 2 and 3 of the
            urotensin II receptor act as biased allosteric ligands
  JOURNAL   J Biol Chem 297 (3), 101057 (2021)
   PUBMED   34389356
  REMARK    GeneRIF: Lipidated peptides derived from intracellular loops 2 and
            3 of the urotensin II receptor act as biased allosteric ligands.
REFERENCE   2  (bases 1 to 3685)
  AUTHORS   Dai,Z., Wang,Y., Wu,Z., Feng,Z., Liu,Z., Qiu,Y., Cheng,J.C., Xu,L.
            and Zhu,Z.
  TITLE     Novel Mutations in UTS2R are Associated with Adolescent Idiopathic
            Scoliosis in the Chinese Population
  JOURNAL   Spine (Phila Pa 1976) 46 (5), E288-E293 (2021)
   PUBMED   33156271
  REMARK    GeneRIF: Novel Mutations in UTS2R are Associated with Adolescent
            Idiopathic Scoliosis in the Chinese Population.
REFERENCE   3  (bases 1 to 3685)
  AUTHORS   Gravina,A.G., Dallio,M., Tuccillo,C., Martorano,M., Abenavoli,L.,
            Luzza,F., Stiuso,P., Lama,S., Grieco,P., Merlino,F., Caraglia,M.,
            Loguercio,C. and Federico,A.
  TITLE     Urotensin II receptor expression in patients with ulcerative
            colitis: a pilot study
  JOURNAL   Minerva Gastroenterol Dietol 66 (1), 23-28 (2020)
   PUBMED   31293119
  REMARK    GeneRIF: Urotensin II receptor expression in patients with
            ulcerative colitis: a pilot study.
REFERENCE   4  (bases 1 to 3685)
  AUTHORS   Coly,P.M., Perzo,N., Le Joncour,V., Lecointre,C., Schouft,M.T.,
            Desrues,L., Tonon,M.C., Wurtz,O., Gandolfo,P., Castel,H. and
            Morin,F.
  TITLE     Chemotactic G protein-coupled receptors control cell migration by
            repressing autophagosome biogenesis
  JOURNAL   Autophagy 12 (12), 2344-2362 (2016)
   PUBMED   27715446
  REMARK    GeneRIF: ligand-induced activation of the chemokine receptor CXCR4
            and the urotensin 2 receptor UTS2R, triggers a marked reduction in
            the biogenesis of autophagosomes.
REFERENCE   5  (bases 1 to 3685)
  AUTHORS   Yang,Y., Zhang,J., Chen,X., Wu,T., Xu,X., Cao,G., Li,H. and Li,Y.
  TITLE     UII/GPR14 is involved in NF-kappaB-mediated colonic inflammation in
            vivo and in vitro
  JOURNAL   Oncol Rep 36 (5), 2800-2806 (2016)
   PUBMED   27600191
  REMARK    GeneRIF: UII/GPR14 signaling was involved in the DSS-induced
            colonic inflammation and its inhibition may serve as a potential
            therapeutic target, which may be associated with the NF-kappaB
            signaling pathway.
REFERENCE   6  (bases 1 to 3685)
  AUTHORS   Protopopov,A., Kashuba,V., Podowski,R., Gizatullin,R.,
            Sonnhammer,E., Wahlestedt,C. and Zabarovsky,E.R.
  TITLE     Assignment of the GPR14 gene coding for the G-protein-coupled
            receptor 14 to human chromosome 17q25.3 by fluorescent in situ
            hybridization
  JOURNAL   Cytogenet Cell Genet 88 (3-4), 312-313 (2000)
   PUBMED   10828617
REFERENCE   7  (bases 1 to 3685)
  AUTHORS   Liu,Q., Pong,S.S., Zeng,Z., Zhang,Q., Howard,A.D., Williams,D.L.
            Jr., Davidoff,M., Wang,R., Austin,C.P., McDonald,T.P., Bai,C.,
            George,S.R., Evans,J.F. and Caskey,C.T.
  TITLE     Identification of urotensin II as the endogenous ligand for the
            orphan G-protein-coupled receptor GPR14
  JOURNAL   Biochem Biophys Res Commun 266 (1), 174-178 (1999)
   PUBMED   10581185
REFERENCE   8  (bases 1 to 3685)
  AUTHORS   Ames,R.S., Sarau,H.M., Chambers,J.K., Willette,R.N., Aiyar,N.V.,
            Romanic,A.M., Louden,C.S., Foley,J.J., Sauermelch,C.F.,
            Coatney,R.W., Ao,Z., Disa,J., Holmes,S.D., Stadel,J.M.,
            Martin,J.D., Liu,W.S., Glover,G.I., Wilson,S., McNulty,D.E.,
            Ellis,C.E., Elshourbagy,N.A., Shabon,U., Trill,J.J., Hay,D.W.,
            Ohlstein,E.H., Bergsma,D.J. and Douglas,S.A.
  TITLE     Human urotensin-II is a potent vasoconstrictor and agonist for the
            orphan receptor GPR14
  JOURNAL   Nature 401 (6750), 282-286 (1999)
   PUBMED   10499587
  REMARK    Erratum:[Nature 1999 Dec 23-30;402(6764):898]
REFERENCE   9  (bases 1 to 3685)
  AUTHORS   Coulouarn,Y., Lihrmann,I., Jegou,S., Anouar,Y., Tostivint,H.,
            Beauvillain,J.C., Conlon,J.M., Bern,H.A. and Vaudry,H.
  TITLE     Cloning of the cDNA encoding the urotensin II precursor in frog and
            human reveals intense expression of the urotensin II gene in
            motoneurons of the spinal cord
  JOURNAL   Proc Natl Acad Sci U S A 95 (26), 15803-15808 (1998)
   PUBMED   9861051
REFERENCE   10 (bases 1 to 3685)
  AUTHORS   Marchese,A., Heiber,M., Nguyen,T., Heng,H.H., Saldivia,V.R.,
            Cheng,R., Murphy,P.M., Tsui,L.C., Shi,X., Gregor,P. et al.
  TITLE     Cloning and chromosomal mapping of three novel genes, GPR9, GPR10,
            and GPR14, encoding receptors related to interleukin 8,
            neuropeptide Y, and somatostatin receptors
  JOURNAL   Genomics 29 (2), 335-344 (1995)
   PUBMED   8666380
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC132938.9.
            
            On Apr 17, 2020 this sequence version replaced NM_018949.2.
            
            Transcript Variant: This variant (1) represents the longer
            transcript. Variants 1 and 2 both encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14372079.3729450.1,
                                           SRR14038192.3964420.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA2145774
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000313135.5/ ENSP00000323516.2
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 5' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-283               AC132938.9         94872-95154         c
            284-469             AC132938.9         94136-94321         c
            470-3685            AC132938.9         89461-92676         c
FEATURES             Location/Qualifiers
     source          1..3685
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q25.3"
     gene            1..3685
                     /gene="UTS2R"
                     /gene_synonym="GPR14; UR-2-R; UTR; UTR2"
                     /note="urotensin 2 receptor"
                     /db_xref="GeneID:2837"
                     /db_xref="HGNC:HGNC:4468"
                     /db_xref="MIM:600896"
     exon            1..283
                     /gene="UTS2R"
                     /gene_synonym="GPR14; UR-2-R; UTR; UTR2"
                     /inference="alignment:Splign:2.1.0"
     exon            284..469
                     /gene="UTS2R"
                     /gene_synonym="GPR14; UR-2-R; UTR; UTR2"
                     /inference="alignment:Splign:2.1.0"
     exon            470..3685
                     /gene="UTS2R"
                     /gene_synonym="GPR14; UR-2-R; UTR; UTR2"
                     /inference="alignment:Splign:2.1.0"
     CDS             552..1721
                     /gene="UTS2R"
                     /gene_synonym="GPR14; UR-2-R; UTR; UTR2"
                     /note="urotensin II receptor; UR-II-R; G-protein coupled
                     receptor 14"
                     /codon_start=1
                     /product="urotensin-2 receptor"
                     /protein_id="NP_061822.1"
                     /db_xref="CCDS:CCDS11810.1"
                     /db_xref="GeneID:2837"
                     /db_xref="HGNC:HGNC:4468"
                     /db_xref="MIM:600896"
                     /translation="MALTPESPSSFPGLAATGSSVPEPPGGPNATLNSSWASPTEPSS
                     LEDLVATGTIGTLLSAMGVVGVVGNAYTLVVTCRSLRAVASMYVYVVNLALADLLYLL
                     SIPFIVATYVTKEWHFGDVGCRVLFGLDFLTMHASIFTLTVMSSERYAAVLRPLDTVQ
                     RPKGYRKLLALGTWLLALLLTLPVMLAMRLVRRGPKSLCLPAWGPRAHRAYLTLLFAT
                     SIAGPGLLIGLLYARLARAYRRSQRASFKRARRPGARALRLVLGIVLLFWACFLPFWL
                     WQLLAQYHQAPLAPRTARIVNYLTTCLTYGNSCANPFLYTLLTRNYRDHLRGRVRGPG
                     SGGGRGPVPSLQPRARFQRCSGRSLSSCSPQPTDSLVLAPAAPARPAPEGPRAPA"
ORIGIN      
        1 gcattcccag ctggcggcgg gcaggtggcg gcggcgcaga gacccggcgc ggggcggggg
       61 gcgcggcttt ggtggcggga ctggcgggcg cccctgccgt gtgctctgga agccgaggcc
      121 accgcggagc ccctcgcgcc ccctctgcgc tgggacaggg gagcgcgcct cggaaagttc
      181 cccgcggccc cgctgcgcga ggagtttgga gccgcgagcg gctgccccca cgcgcgaccc
      241 caggctcggc gggcaggtct ggccgctcag tgaccggagg cagcccacca ccgcgctgtt
      301 tcatccaggc tgctgacccc agcggcgact ccttcactgg cttcatgtca cagtttgcct
      361 gccccgtcca ctggggacat ttgagctgtt tccagcttct taggagtcaa gctgccgtga
      421 actttcgcac gcttgtcatt ttctgaacgt tggcagccct ttatctaagg ctgagctggt
      481 tgcccacagg ggcccccgcc ccatctcagg gagtgtccac ccagccctga gcccgtcgtg
      541 aggggtcaga gatggcgctg acccccgagt ccccgagcag cttccctggg ctggccgcca
      601 ctggcagctc tgtgccggag ccgcctggcg gccccaacgc aaccctcaac agctcctggg
      661 ccagcccgac cgagcccagc tccctggagg acctggtggc cacgggcacc attgggactc
      721 tgctgtcggc catgggcgtg gtgggcgtgg tgggcaacgc ctacacgctg gtggtcacct
      781 gccgctccct gcgtgcggtg gcctccatgt acgtctacgt ggtcaacctg gcgctggccg
      841 acctgctgta cctgctcagc atccccttca tcgtggccac ctacgtcacc aaggagtggc
      901 acttcgggga cgtgggctgc cgcgtgctct tcggcctgga cttcctgacc atgcacgcca
      961 gcatcttcac gctgaccgtc atgagcagcg agcgctacgc tgcggtgctg cggccgctgg
     1021 acaccgtgca gcgccccaag ggctaccgca agctgctggc gctgggcacc tggctgctgg
     1081 cgctgctgct gacgctgccc gtgatgctgg ccatgcggct ggtgcgccgg ggtcccaaga
     1141 gcctgtgcct gcccgcctgg ggcccgcgcg cccaccgcgc ctacctgacg ctgctcttcg
     1201 ccaccagcat cgcggggccc gggctgctca tcgggctgct ctacgcgcgc ctggcccgcg
     1261 cctaccgccg ctcgcagcgc gcctccttca agcgggcccg gcggccgggg gcgcgcgcgc
     1321 tgcgcctggt gctgggcatc gtgctgctct tctgggcctg cttcctgccc ttctggctgt
     1381 ggcagctgct cgcccagtac caccaggccc cgctggcgcc gcggacggcg cgcatcgtca
     1441 actacctgac cacctgcctc acctacggca acagctgcgc caaccccttc ctctacacgc
     1501 tgctcaccag gaactaccgc gaccacctgc gcggccgcgt gcggggcccg ggcagcgggg
     1561 gaggccgggg gcccgttccc tccctgcagc cccgcgcccg cttccagcgc tgttcgggcc
     1621 gctccctgtc ttcctgcagc ccacagccca ctgacagcct cgtgctggcc ccagcggccc
     1681 cggcccgacc tgcgcccgag ggtcccaggg ccccggcgtg agcacgcgga ggggcggctg
     1741 gagtccaggc ggggacgcgc cccaaagccc cagccactcc cgggagcccc cccaactccc
     1801 aaatcacagg ccctgcccct cctccgtccc cttctggaaa gatcctgctc gcttcccctc
     1861 agcgcccttc ccgtgatgcc cagaagcgcc cacccgcctc cctgagggtc tccaggaggc
     1921 tccagcgcag tcccggcttc tggagaccat ggcttcgtca cagagggcag caggcgccag
     1981 tgcccggccc gtgtggagac catggcgcgg ctgccgcccc cgggaccctc ctcctctcag
     2041 ccagcggccc tgtgactcct gttcctgcct gtgtggctcc atcccttgtg gctttgccac
     2101 tggaacaatc aaccctgagc tggcttccgt gtcctgccta ggcgcggggg acgccacatc
     2161 tgaggtgtgg gaggatcggc cggcaggatc cccaggacga caacggcagc tcaaggggga
     2221 gcctgtgggt ctggctgggg tagagggtgc acctgccttt gaggcctgtg caggcggctg
     2281 gtctggcacc tgatgtgggg cagggaaggt ggccaggagg ggaggctcca gctgaggggt
     2341 ggagcaggga aggcactgcc cagcagaggc ctgaggcttt gggtgcagaa cgcaagagga
     2401 caaggtcagt ggccgcacct acaggcctcc tggcctctca tccacgtctg gctcaggtct
     2461 gatcagaaag ggaatccagg tcccacctca cagtagcatt ggcagtctct gccccactca
     2521 cccctcactg cctcctggac agacttcctg ccccagctcc cagcttggcc aaccatcctc
     2581 tctctggcga ctgcccccct ccagccccca gcccggcccc ggaccctgca tggcctcccc
     2641 cagcctggcc tcccctcccc accccatggc catgcccaga ctaccagccc cttggggctc
     2701 catctgaaca ctggggcaag ggtcatgccc gcttggtccc tccagtgcct acccctcagt
     2761 ggagtgagca cagctctgct ggcaggactg tggccggcgt caggaataag catgcagcgc
     2821 tctccccagg gcctcccgga agaggggcaa tgcttgcagc tcccccctgg agttacgaaa
     2881 gtgctctgga actagacgct ggtgactggg cgatgctgtg aacgagccag tgccacagaa
     2941 ctgtgcacct gaatgtgtga gttctgtcgt gttttacttt aaaaacaaaa ggatcccact
     3001 ccccgacctt gtccctctgt taaaattgaa agagactgat gtcagccgcc ccgtctggga
     3061 gggaggtggg ggggtcagcc ccccgcccgg ccagccaccc cgtccgggag gtgaggggcg
     3121 cctctgcccg gccaccccta ctgggaagtg aggagcccct ctgcccggcc accaccccgt
     3181 ctgggaggtg tgcccagcag ctcattgaga acgggccatg atgacaatgg cggttttgtg
     3241 gaatagaaag gcaggaaagg tggggaaaag attgagaaat cggatggttg ccgtgtctgt
     3301 gtagaaagaa gtagacatgg gagacttttc attttgttct gtactaagaa aaattcttct
     3361 gccttgggat cctgttgatc tatgacctta cccccaaccc tgtgctctct gaaacatgtg
     3421 ctgtgtccac tcagggttga atggattaag ggcggtgcaa gatgtgcttt gttaaacaga
     3481 tgcttgaagg cagcacgctc gttaggagtc atcaccactc cctaatctca agtacccagg
     3541 gacacaaaca ctgcggaagg ccgcagggtc ctctgcctag gaaaaccaga gacctttgtt
     3601 cacttgttta tctgctgacc ttccctccac tattgtccta tgaccctgcc aaatccccct
     3661 ctgcgagaaa cacccaagaa tgatc
//
