LOCUS       NM_198152               2385 bp    mRNA    linear   PRI 08-APR-2024
DEFINITION  Homo sapiens urotensin 2B (UTS2B), mRNA.
ACCESSION   NM_198152
VERSION     NM_198152.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2385)
  AUTHORS   Debiec,R., Christofidou,P., Denniff,M., Bloomer,L.D., Bogdanski,P.,
            Wojnar,L., Musialik,K., Charchar,F.J., Thompson,J.R.,
            Waterworth,D., Song,K., Vollenweider,P., Waeber,G.,
            Zukowska-Szczechowska,E., Samani,N.J., Lambert,D. and
            Tomaszewski,M.
  TITLE     Urotensin-II system in genetic control of blood pressure and renal
            function
  JOURNAL   PLoS One 8 (12), e83137 (2013)
   PUBMED   24391740
  REMARK    GeneRIF: family-based analysis of association between blood
            pressure, glomerular filtration and genes of the urotensin-II
            pathway (urotensin-II, urotensin-II related peptide, urotensin-II
            receptor) saturated with 28 tagging single nucleotide polymorphisms
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2385)
  AUTHORS   Williams,S.G. and Hall,K.B.
  TITLE     Human U2B'' protein binding to snRNA stemloops
  JOURNAL   Biophys Chem 159 (1), 82-89 (2011)
   PUBMED   21684671
  REMARK    GeneRIF: U2B'' has a relaxed specificity for its RNA targets.
REFERENCE   3  (bases 1 to 2385)
  AUTHORS   Furney,S.J., Simmons,A., Breen,G., Pedroso,I., Lunnon,K.,
            Proitsi,P., Hodges,A., Powell,J., Wahlund,L.O., Kloszewska,I.,
            Mecocci,P., Soininen,H., Tsolaki,M., Vellas,B., Spenger,C.,
            Lathrop,M., Shen,L., Kim,S., Saykin,A.J., Weiner,M.W. and
            Lovestone,S.
  CONSRTM   Alzheimer's Disease Neuroimaging Initiative; AddNeuroMed Consortium
  TITLE     Genome-wide association with MRI atrophy measures as a quantitative
            trait locus for Alzheimer's disease
  JOURNAL   Mol Psychiatry 16 (11), 1130-1138 (2011)
   PUBMED   21116278
REFERENCE   4  (bases 1 to 2385)
  AUTHORS   Djordjevic,T. and Gorlach,A.
  TITLE     Urotensin-II in the lung: a matter for vascular remodelling and
            pulmonary hypertension?
  JOURNAL   Thromb Haemost 98 (5), 952-962 (2007)
   PUBMED   18000598
  REMARK    GeneRIF: vascular remodelling processes in conjunction with
            enhanced vasoconstriction are involved in the pathogenesis of
            pulmonary hypertension; UII may play a novel role in the
            pathogenesis of this disorder
            Review article
REFERENCE   5  (bases 1 to 2385)
  AUTHORS   Kemp,W., Krum,H., Colman,J., Bailey,M., Yandle,T., Richards,M. and
            Roberts,S.
  TITLE     Urotensin II: a novel vasoactive mediator linked to chronic liver
            disease and portal hypertension
  JOURNAL   Liver Int 27 (9), 1232-1239 (2007)
   PUBMED   17919235
  REMARK    GeneRIF: Elevated serum urotensin II is associated with chronic
            liver disease and portal hypertension
REFERENCE   6  (bases 1 to 2385)
  AUTHORS   Tan,Y.J., Fan,Z.T. and Yang,H.X.
  TITLE     [Role of urotensin II gene in the genetic susceptibility to
            gestational diabetes mellitus in northern Chinese women]
  JOURNAL   Zhonghua Fu Chan Ke Za Zhi 41 (11), 732-735 (2006)
   PUBMED   17327028
  REMARK    GeneRIF: Urotensin II gene may contribute to the genetic
            susceptibility to gestational diabetes mellitus in Chinese
            population
REFERENCE   7  (bases 1 to 2385)
  AUTHORS   Dowal,L., Provitera,P. and Scarlata,S.
  TITLE     Stable association between G alpha(q) and phospholipase C beta 1 in
            living cells
  JOURNAL   J Biol Chem 281 (33), 23999-24014 (2006)
   PUBMED   16754659
REFERENCE   8  (bases 1 to 2385)
  AUTHORS   Watanabe,T., Kanome,T., Miyazaki,A. and Katagiri,T.
  TITLE     Human urotensin II as a link between hypertension and coronary
            artery disease
  JOURNAL   Hypertens Res 29 (6), 375-387 (2006)
   PUBMED   16940699
  REMARK    GeneRIF: These findings suggest that U-II plays key roles in
            accelerating the development of atherosclerosis, thereby leading to
            coronary artery disease.
            Review article
REFERENCE   9  (bases 1 to 2385)
  AUTHORS   Sugo,T., Murakami,Y., Shimomura,Y., Harada,M., Abe,M.,
            Ishibashi,Y., Kitada,C., Miyajima,N., Suzuki,N., Mori,M. and
            Fujino,M.
  TITLE     Identification of urotensin II-related peptide as the urotensin
            II-immunoreactive molecule in the rat brain
  JOURNAL   Biochem Biophys Res Commun 310 (3), 860-868 (2003)
   PUBMED   14550283
  REMARK    GeneRIF: URP could possibly be the endogenous and functional ligand
            for the human UII receptor
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC068645.11 and AC126567.8.
            
            On Jan 25, 2021 this sequence version replaced NM_198152.4.
            
            Sequence Note:.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK090630.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1968189 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000340524.10/ ENSP00000340526.5
            RefSeq Select criteria :: based on manual assertion
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-113               AC068645.11        53195-53307
            114-192             AC068645.11        55012-55090
            193-596             AC068645.11        67282-67685
            597-653             AC068645.11        79173-79229
            654-880             AC126567.8         17655-17881
            881-979             AC126567.8         21798-21896
            980-1017            AC126567.8         23124-23161
            1018-1111           AC126567.8         24623-24716
            1112-2385           AC126567.8         31527-32800
FEATURES             Location/Qualifiers
     source          1..2385
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3q28"
     gene            1..2385
                     /gene="UTS2B"
                     /gene_synonym="U-IIB; U2B; UIIB; URP; UTS2D"
                     /note="urotensin 2B"
                     /db_xref="GeneID:257313"
                     /db_xref="HGNC:HGNC:30894"
                     /db_xref="MIM:618134"
     exon            1..113
                     /gene="UTS2B"
                     /gene_synonym="U-IIB; U2B; UIIB; URP; UTS2D"
                     /inference="alignment:Splign:2.1.0"
     exon            114..192
                     /gene="UTS2B"
                     /gene_synonym="U-IIB; U2B; UIIB; URP; UTS2D"
                     /inference="alignment:Splign:2.1.0"
     exon            193..596
                     /gene="UTS2B"
                     /gene_synonym="U-IIB; U2B; UIIB; URP; UTS2D"
                     /inference="alignment:Splign:2.1.0"
     exon            597..653
                     /gene="UTS2B"
                     /gene_synonym="U-IIB; U2B; UIIB; URP; UTS2D"
                     /inference="alignment:Splign:2.1.0"
     exon            654..880
                     /gene="UTS2B"
                     /gene_synonym="U-IIB; U2B; UIIB; URP; UTS2D"
                     /inference="alignment:Splign:2.1.0"
     CDS             778..1137
                     /gene="UTS2B"
                     /gene_synonym="U-IIB; U2B; UIIB; URP; UTS2D"
                     /note="urotensin II-related peptide; urotensin IIB;
                     urotensin 2 domain containing; prepro-URP; urotensin-2
                     domain-containing protein"
                     /codon_start=1
                     /product="urotensin-2B precursor"
                     /protein_id="NP_937795.2"
                     /db_xref="CCDS:CCDS3300.1"
                     /db_xref="GeneID:257313"
                     /db_xref="HGNC:HGNC:30894"
                     /db_xref="MIM:618134"
                     /translation="MNKILSSTVCFGLLTLLSVLSFLQSVHGRPYLTQGNEIFPDKKY
                     TNREELLLALLNKNFDFQRPFNTDLALPNKLEELNQLEKLKEQLVEEKDSETSYAVDG
                     LFSSHPSKRACFWKYCV"
     exon            881..979
                     /gene="UTS2B"
                     /gene_synonym="U-IIB; U2B; UIIB; URP; UTS2D"
                     /inference="alignment:Splign:2.1.0"
     exon            980..1017
                     /gene="UTS2B"
                     /gene_synonym="U-IIB; U2B; UIIB; URP; UTS2D"
                     /inference="alignment:Splign:2.1.0"
     exon            1018..1111
                     /gene="UTS2B"
                     /gene_synonym="U-IIB; U2B; UIIB; URP; UTS2D"
                     /inference="alignment:Splign:2.1.0"
     exon            1112..2385
                     /gene="UTS2B"
                     /gene_synonym="U-IIB; U2B; UIIB; URP; UTS2D"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2365..2370
                     /regulatory_class="polyA_signal_sequence"
                     /gene="UTS2B"
                     /gene_synonym="U-IIB; U2B; UIIB; URP; UTS2D"
                     /note="hexamer: ATTAAA"
     polyA_site      2385
                     /gene="UTS2B"
                     /gene_synonym="U-IIB; U2B; UIIB; URP; UTS2D"
                     /note="major polyA site"
ORIGIN      
        1 ataaggcgat ccagcaccta agatctcagc aaaaaaaagc taggtcctga ggcagctagt
       61 ggaaaaacaa gagaagggaa gtcaaaaggc tacttgctgt cagctaaagc cagacaacct
      121 ctcctgtttc atctcctggc aacagaatgc atcctccttt tgggaaactg cctctttccc
      181 cactcctcag agtaaatctt gctgctgctc actctttggg tctgcactgc ccataagagc
      241 tgtagcactc accgcgaagg tctgcagctt cactcttgaa accagagaga ccacgaacct
      301 accgggagaa atgaacaaat tccggacgca ccatctttaa gaactgtaac actcactgcg
      361 aggatctgcg gcttcattct ttaagtctgt gagaccaaga acccaccaat tccggcacac
      421 taatatgctg ttggaaactg gctatatgga aaggctatgt ggaagaaaac aaacacccca
      481 gccaacataa tggagctccc agctgacagc tgacatctag ctgattgcca accactttgg
      541 aaactgatct tcaaaaccca cttgagctat gtcaagagaa gccacctgtg acacagaagc
      601 agaaggatcc aagtcaaagg agtttatttg ggaggaaata gcacgagaga atgatcattc
      661 gtaactgagg cacacttgcc ttttgcaact aagctctact gaattccaaa gctatagaaa
      721 tatccatctt gacctggaaa gtctgtttct ttgctagtcc agaaggtttt ttttaacatg
      781 aacaagatcc tctcaagcac tgtttgcttt ggactcctaa ctttgttatc cgtgttgagt
      841 tttttacaat ctgtgcatgg acgaccatat cttacccaag gaaatgaaat atttccagat
      901 aaaaaatata caaatcgtga ggaactattg ctggctctac tgaataaaaa ttttgatttc
      961 caaagacctt tcaacactga cctagcctta cctaacaaac tggaagaact taaccagctg
     1021 gaaaagctaa aagaacagct agtggaggag aaggattctg agacgtccta tgctgtagat
     1081 ggtctattct cttctcatcc tagcaaacga gcttgctttt ggaaatactg tgtttaaagc
     1141 tttttctctg gatgcaaaaa aagataagaa tatcaggaaa atatatgtat ctactcactc
     1201 tgctgtaggc agaccccctg aaactattgc tgtggaataa aagatgaaat gctcctgatt
     1261 attgtaaata caaaattgca tgcgggattg tgtaaagaca atgccaggtt ggactgccag
     1321 aatgagccaa cagcacttgc ttccccctgt agagagccta tgaatggacg tgcagtcagg
     1381 gaggtttcat atcaccaaga ttcctatccc agaaaagcag atgttcatag ctctgggaat
     1441 ggaatgcgcc cctcgtggag agcctataaa cggatgcatg gaaggcgcct gtccatatgg
     1501 ataagatagg gttgtaaacg tcctcatctt gccatggctc ttctaggcct ctttagggtt
     1561 aaggcatatt tccttctgag aatttctggt ctaagcggtt gtctagcttc atgtcctgtt
     1621 tccatggatt gtttgtaacc agcttttgtt acaattgtta ctgctgatta atatcttgct
     1681 aatcataggt tatggaaaga ttgtgtttct gttttaaggc tctgttagaa attacacaca
     1741 cagtatattg taaattctta tctctgtata ctgtacttct acatacaaat gtactgtact
     1801 tctacataca aatgttatgt taaagaatta cttcatcccc atgtgaccat ctcacctcat
     1861 aatcaaatga ccctaaatcc ctcattaacc tacccctgcc cttgctaaac ttaataataa
     1921 atgctggtat atccagtgca ttgttggcac catgggacca gaaggtggtg acccccctgg
     1981 acccagcttt cactatcttg tgtgtgtctg ttatttctca acctgctgat ccgcctggga
     2041 acaaagagcc ccgttgcatt gcgggctact ggccagatcc cgcaatactc tgctatttaa
     2101 aattgtagct gtttcaatca taaagaaact ggcatttatt atgcatatga ttttttcacc
     2161 ttgttcttgt tactaagtca attatgataa gcttaaggtt tatgttgtga ataatcacta
     2221 atcagttgca cttttgaagg tatgtcacta tcaaaatggt tttgtagagc tagagttgaa
     2281 aatgctgtat ctattgtatg ctttccataa attcattgct tatgtaaagt tttgtcctgt
     2341 tgtgactatg ctgttgaact attaattaaa acattttgaa aagca
//
