LOCUS       NM_006786                591 bp    mRNA    linear   PRI 06-APR-2024
DEFINITION  Homo sapiens urotensin 2 (UTS2), transcript variant 2, mRNA.
ACCESSION   NM_006786
VERSION     NM_006786.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 591)
  AUTHORS   Nassour,H., Petrin,D., Devost,D., Billard,E., Sleno,R., Hebert,T.E.
            and Chatenet,D.
  TITLE     Evidence for heterodimerization and functional interaction of the
            urotensin II and the angiotensin II type 1 receptors
  JOURNAL   Cell Signal 116, 111056 (2024)
   PUBMED   38262555
  REMARK    GeneRIF: Evidence for heterodimerization and functional interaction
            of the urotensin II and the angiotensin II type 1 receptors.
REFERENCE   2  (bases 1 to 591)
  AUTHORS   Mihovilovic,A., Dogas,Z., Martinovic,D., Tokic,D., Puizina
            Mladinic,E., Kumric,M., Ivkovic,N., Vilovic,M. and Bozic,J.
  TITLE     Serum Urotensin II Levels Are Elevated in Patients with Obstructive
            Sleep Apnea
  JOURNAL   Biomolecules 13 (6), 914 (2023)
   PUBMED   37371494
  REMARK    GeneRIF: Serum Urotensin II Levels Are Elevated in Patients with
            Obstructive Sleep Apnea.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 591)
  AUTHORS   Zhang,Y. and Chen,G.X.
  TITLE     Urotensin II level is elevated in inflammatory bowel disease
            patients
  JOURNAL   World J Gastroenterol 28 (35), 5230-5232 (2022)
   PUBMED   36188724
  REMARK    GeneRIF: Urotensin II level is elevated in inflammatory bowel
            disease patients.
REFERENCE   4  (bases 1 to 591)
  AUTHORS   Kamal,A., Elgengehy,F.T., Elawady,Z., Fawzy,N.A. and El Sisi,O.
  TITLE     Role of miR-146a rs2910164 and UTS2 rs228648 Genetic Variants in
            Behcet's Disease
  JOURNAL   Immunol Invest 51 (4), 899-908 (2022)
   PUBMED   33605830
  REMARK    GeneRIF: Role of miR-146a rs2910164 and UTS2 rs228648 Genetic
            Variants in Behcet's Disease.
REFERENCE   5  (bases 1 to 591)
  AUTHORS   Yin,C.L., Liu,X., Wang,H.X., Yan,M.C., Guo,L.J., Li,G.N., Xia,J.G.,
            Yuan,H.H. and Yin,Y.
  TITLE     Dynamic Changes in Plasma Urotensin II and Its Correlation With
            Plaque Stability
  JOURNAL   J Cardiovasc Pharmacol 78 (1), e147-e155 (2021)
   PUBMED   34173803
  REMARK    GeneRIF: Dynamic Changes in Plasma Urotensin II and Its Correlation
            With Plaque Stability.
REFERENCE   6  (bases 1 to 591)
  AUTHORS   Zatelli,M.C., Tagliati,F., Taylor,J.E., Rossi,R., Culler,M.D. and
            degli Uberti,E.C.
  TITLE     Somatostatin receptor subtypes 2 and 5 differentially affect
            proliferation in vitro of the human medullary thyroid carcinoma
            cell line tt
  JOURNAL   J Clin Endocrinol Metab 86 (5), 2161-2169 (2001)
   PUBMED   11344221
REFERENCE   7  (bases 1 to 591)
  AUTHORS   Liu,Q., Pong,S.S., Zeng,Z., Zhang,Q., Howard,A.D., Williams,D.L.
            Jr., Davidoff,M., Wang,R., Austin,C.P., McDonald,T.P., Bai,C.,
            George,S.R., Evans,J.F. and Caskey,C.T.
  TITLE     Identification of urotensin II as the endogenous ligand for the
            orphan G-protein-coupled receptor GPR14
  JOURNAL   Biochem Biophys Res Commun 266 (1), 174-178 (1999)
   PUBMED   10581185
REFERENCE   8  (bases 1 to 591)
  AUTHORS   Ames,R.S., Sarau,H.M., Chambers,J.K., Willette,R.N., Aiyar,N.V.,
            Romanic,A.M., Louden,C.S., Foley,J.J., Sauermelch,C.F.,
            Coatney,R.W., Ao,Z., Disa,J., Holmes,S.D., Stadel,J.M.,
            Martin,J.D., Liu,W.S., Glover,G.I., Wilson,S., McNulty,D.E.,
            Ellis,C.E., Elshourbagy,N.A., Shabon,U., Trill,J.J., Hay,D.W.,
            Ohlstein,E.H., Bergsma,D.J. and Douglas,S.A.
  TITLE     Human urotensin-II is a potent vasoconstrictor and agonist for the
            orphan receptor GPR14
  JOURNAL   Nature 401 (6750), 282-286 (1999)
   PUBMED   10499587
  REMARK    Erratum:[Nature 1999 Dec 23-30;402(6764):898]
REFERENCE   9  (bases 1 to 591)
  AUTHORS   Coulouarn,Y., Lihrmann,I., Jegou,S., Anouar,Y., Tostivint,H.,
            Beauvillain,J.C., Conlon,J.M., Bern,H.A. and Vaudry,H.
  TITLE     Cloning of the cDNA encoding the urotensin II precursor in frog and
            human reveals intense expression of the urotensin II gene in
            motoneurons of the spinal cord
  JOURNAL   Proc Natl Acad Sci U S A 95 (26), 15803-15808 (1998)
   PUBMED   9861051
REFERENCE   10 (bases 1 to 591)
  AUTHORS   Jais,P., Terris,B., Ruszniewski,P., LeRomancer,M., Reyl-Desmars,F.,
            Vissuzaine,C., Cadiot,G., Mignon,M. and Lewin,M.J.
  TITLE     Somatostatin receptor subtype gene expression in human endocrine
            gastroentero-pancreatic tumours
  JOURNAL   Eur J Clin Invest 27 (8), 639-644 (1997)
   PUBMED   9279525
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from Z98884.11, AY358375.1 and
            AF104118.1.
            
            On Jun 2, 2019 this sequence version replaced NM_006786.3.
            
            Summary: This gene encodes a mature peptide that is an active
            cyclic heptapeptide absolutely conserved from lamprey to human. The
            active peptide acts as a vasoconstrictor and is expressed only in
            brain tissue. Despite the gene family name similarity, this gene is
            not homologous to urocortin, a member of the
            sauvagine/corticotropin-releasing factor/urotensin I family. Most
            of the proprotein is cleaved to make the mature peptide. Transcript
            variants encoding different preproprotein isoforms have been
            described for this gene. [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (2) encodes a shorter
            preproprotein isoform (b) of 124 amino acids with a different
            amino-terminal end compared to isoform a. The mature peptide is
            identical for both transcript variants.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY358375.1, AV755530.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN03267753 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000361696.10/ ENSP00000355163.5
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-21                Z98884.11          130264-130284       c
            22-30               AY358375.1         1-9
            31-581              AF104118.1         1-551
            582-591             AY358375.1         561-570
FEATURES             Location/Qualifiers
     source          1..591
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p36.23"
     gene            1..591
                     /gene="UTS2"
                     /gene_synonym="PRO1068; U-II; UCN2; UII"
                     /note="urotensin 2"
                     /db_xref="GeneID:10911"
                     /db_xref="HGNC:HGNC:12636"
                     /db_xref="MIM:604097"
     exon            1..165
                     /gene="UTS2"
                     /gene_synonym="PRO1068; U-II; UCN2; UII"
                     /inference="alignment:Splign:2.1.0"
     CDS             63..437
                     /gene="UTS2"
                     /gene_synonym="PRO1068; U-II; UCN2; UII"
                     /note="isoform b preproprotein is encoded by transcript
                     variant 2; prepro U-II; urotensin II"
                     /codon_start=1
                     /product="urotensin-2 isoform b preproprotein"
                     /protein_id="NP_006777.1"
                     /db_xref="CCDS:CCDS91.1"
                     /db_xref="GeneID:10911"
                     /db_xref="HGNC:HGNC:12636"
                     /db_xref="MIM:604097"
                     /translation="MYKLASCCLLFIGFLNPLLSLPLLDSREISFQLSAPHEDARLTP
                     EELERASLLQILPEMLGAERGDILRKADSSTNIFNPRGNLRKFQDFSGQDPNILLSHL
                     LARIWKPYKKRETPDCFWKYCV"
     exon            166..276
                     /gene="UTS2"
                     /gene_synonym="PRO1068; U-II; UCN2; UII"
                     /inference="alignment:Splign:2.1.0"
     exon            277..320
                     /gene="UTS2"
                     /gene_synonym="PRO1068; U-II; UCN2; UII"
                     /inference="alignment:Splign:2.1.0"
     exon            321..591
                     /gene="UTS2"
                     /gene_synonym="PRO1068; U-II; UCN2; UII"
                     /inference="alignment:Splign:2.1.0"
     regulatory      568..573
                     /regulatory_class="polyA_signal_sequence"
                     /gene="UTS2"
                     /gene_synonym="PRO1068; U-II; UCN2; UII"
                     /note="hexamer: AATAAA"
     polyA_site      591
                     /gene="UTS2"
                     /gene_synonym="PRO1068; U-II; UCN2; UII"
                     /note="major polyA site"
ORIGIN      
        1 gagacagttg aaagttctct acaacagaag ccaagaagga agccgtctat cttgtggcga
       61 tcatgtataa gctggcctcc tgctgtttgc ttttcatagg attcttaaat cctctcttat
      121 ctcttcctct ccttgactcc agggaaatat cctttcaact ctcagcacct catgaagacg
      181 cgcgcttaac tccggaggag ctagaaagag cttcccttct acagatactg ccagagatgc
      241 tgggtgcaga aagaggggat attctcagga aagcagactc aagtaccaac atttttaacc
      301 caagaggaaa tttgagaaag tttcaggatt tctctggaca agatcctaac attttactga
      361 gtcatctttt ggccagaatc tggaaaccat acaagaaacg tgagactcct gattgcttct
      421 ggaaatactg tgtctgaagt gaaataagca tctgttagtc agctcagaaa cacccatctt
      481 agaatatgaa aaataacaca atgcttgatt tgaaaacagt gtggagaaaa actaggcaaa
      541 ctacaccctg ttcattgtta cctggaaaat aaatcctcta tgttttgcac a
//
