LOCUS       NM_020368               2020 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens UTP3 small subunit processome component (UTP3), mRNA.
ACCESSION   NM_020368
VERSION     NM_020368.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2020)
  AUTHORS   Nan,Y., Luo,Q., Wu,X., Chang,W., Zhao,P., Liu,S. and Liu,Z.
  TITLE     HCP5 prevents ubiquitination-mediated UTP3 degradation to inhibit
            apoptosis by activating c-Myc transcriptional activity
  JOURNAL   Mol Ther 31 (2), 552-568 (2023)
   PUBMED   36245126
  REMARK    GeneRIF: HCP5 prevents ubiquitination-mediated UTP3 degradation to
            inhibit apoptosis by activating c-Myc transcriptional activity.
REFERENCE   2  (bases 1 to 2020)
  AUTHORS   Singh,S., Vanden Broeck,A., Miller,L., Chaker-Margot,M. and
            Klinge,S.
  TITLE     Nucleolar maturation of the human small subunit processome
  JOURNAL   Science 373 (6560), eabj5338 (2021)
   PUBMED   34516797
REFERENCE   3  (bases 1 to 2020)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   4  (bases 1 to 2020)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 2020)
  AUTHORS   Choi,S.Y., Pi,J.H., Park,S.K. and Kang,C.J.
  TITLE     Crlz-1 Controls Germinal Center Reaction by Relaying a Wnt Signal
            to the Bcl-6 Expression in Centroblasts during Humoral Immune
            Responses
  JOURNAL   J Immunol 203 (10), 2630-2643 (2019)
   PUBMED   31586036
  REMARK    GeneRIF: Crlz-1, which is induced by canonical Wnt/beta-catenin
            signaling, controls Germinal Center reaction by regulating the
            expression of Bcl-6 in centroblasts.
REFERENCE   6  (bases 1 to 2020)
  AUTHORS   Nousiainen,M., Sillje,H.H., Sauer,G., Nigg,E.A. and Korner,R.
  TITLE     Phosphoproteome analysis of the human mitotic spindle
  JOURNAL   Proc Natl Acad Sci U S A 103 (14), 5391-5396 (2006)
   PUBMED   16565220
REFERENCE   7  (bases 1 to 2020)
  AUTHORS   Stelzl,U., Worm,U., Lalowski,M., Haenig,C., Brembeck,F.H.,
            Goehler,H., Stroedicke,M., Zenkner,M., Schoenherr,A., Koeppen,S.,
            Timm,J., Mintzlaff,S., Abraham,C., Bock,N., Kietzmann,S.,
            Goedde,A., Toksoz,E., Droege,A., Krobitsch,S., Korn,B.,
            Birchmeier,W., Lehrach,H. and Wanker,E.E.
  TITLE     A human protein-protein interaction network: a resource for
            annotating the proteome
  JOURNAL   Cell 122 (6), 957-968 (2005)
   PUBMED   16169070
REFERENCE   8  (bases 1 to 2020)
  AUTHORS   Andersen,J.S., Lam,Y.W., Leung,A.K., Ong,S.E., Lyon,C.E.,
            Lamond,A.I. and Mann,M.
  TITLE     Nucleolar proteome dynamics
  JOURNAL   Nature 433 (7021), 77-83 (2005)
   PUBMED   15635413
REFERENCE   9  (bases 1 to 2020)
  AUTHORS   Andersen,J.S., Lyon,C.E., Fox,A.H., Leung,A.K., Lam,Y.W., Steen,H.,
            Mann,M. and Lamond,A.I.
  TITLE     Directed proteomic analysis of the human nucleolus
  JOURNAL   Curr Biol 12 (1), 1-11 (2002)
   PUBMED   11790298
REFERENCE   10 (bases 1 to 2020)
  AUTHORS   Simpson,J.C., Wellenreuther,R., Poustka,A., Pepperkok,R. and
            Wiemann,S.
  TITLE     Systematic subcellular localization of novel proteins identified by
            large-scale cDNA sequencing
  JOURNAL   EMBO Rep 1 (3), 287-292 (2000)
   PUBMED   11256614
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK026909.1.
            
            On Nov 23, 2018 this sequence version replaced NM_020368.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript is intronless :: AF271212.1, AK026909.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000254803.4/ ENSP00000254803.2
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2020              AK026909.1         3-2022
FEATURES             Location/Qualifiers
     source          1..2020
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4q13.3"
     gene            1..2020
                     /gene="UTP3"
                     /gene_synonym="CRL1; CRLZ1; SAS10"
                     /note="UTP3 small subunit processome component"
                     /db_xref="GeneID:57050"
                     /db_xref="HGNC:HGNC:24477"
                     /db_xref="MIM:611614"
     exon            1..2020
                     /gene="UTP3"
                     /gene_synonym="CRL1; CRLZ1; SAS10"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1626..1631
                     /regulatory_class="polyA_signal_sequence"
                     /gene="UTP3"
                     /gene_synonym="CRL1; CRLZ1; SAS10"
                     /note="hexamer: AATAAA"
     polyA_site      1649
                     /gene="UTP3"
                     /gene_synonym="CRL1; CRLZ1; SAS10"
                     /note="major polyA site"
     regulatory      1994..1999
                     /regulatory_class="polyA_signal_sequence"
                     /gene="UTP3"
                     /gene_synonym="CRL1; CRLZ1; SAS10"
                     /note="hexamer: AATAAA"
     polyA_site      2020
                     /gene="UTP3"
                     /gene_synonym="CRL1; CRLZ1; SAS10"
                     /note="major polyA site"
ORIGIN      
        1 agtagccgat caggagtctg caaactccgg tggtagggga gcgcgctgct gtttagagcc
       61 acgagttacc ggagcgcctg attcctgcgc cgaagtcagt ggtggccgaa agtccggagt
      121 cgctgtaaaa cctgagattg tgagccatgg tggggagatc ccggcggcgc ggagcagcta
      181 agtgggcagc tgtgcgagcc aaggcaggtc ccacgctcac cgacgaaaat ggagatgatt
      241 taggattgcc accctcacca ggggacacca gctactacca agatcaggta gatgactttc
      301 atgaggcacg atcccgggcc gccttagcta agggctggaa tgaagtacag agtggagacg
      361 aggaggatgg cgaggaggag gaggaggagg tgctagccct agatatggac gatgaggacg
      421 acgaagatgg agggaatgcg ggggaggagg aggaggagga gaatgccgat gatgatggtg
      481 ggagctccgt gcaaagtgaa gctgaggcct ctgtggatcc cagtttgtcg tggggtcaga
      541 ggaaaaaact ttactatgac acggactatg gttccaagtc ccgaggccgg cagagtcaac
      601 aggaggcaga ggaggaggaa agagaggagg aggaggaggc acagatcatt cagcggcgcc
      661 tagcccaagc gctgcaagag gatgattttg gtgtcgcctg ggttgaggcc tttgcaaaac
      721 cagtgcctca ggtagatgag gctgagacac gggtcgtgaa ggatttggct aaagtttcag
      781 tgaaagagaa gctgaaaatg ttgcgaaagg aatcaccaga actcttggag ctgatagaag
      841 acctgaaagt caagttgaca gaggttaagg atgagctgga gccattgtta gagttggtgg
      901 aacaagggat cattccaccc ggaaaaggaa gccaatactt gaggaccaag tacaacctct
      961 acttgaatta ttgctcgaac atcagttttt atttgatcct gaaagctagg agagtcccag
     1021 cacatggaca tcctgtcata gaaaggcttg ttacctaccg aaatttgatc aacaagctgt
     1081 ccgttgtgga tcagaagctg tcctcagaaa ttcgtcatct gttgacactt aaggatgatg
     1141 ctgtaaagaa agaactgatt ccaaaagcaa aatccaccaa gcccaaacca aagtctgttt
     1201 caaagacttc tgctgctgcc tgtgctgtta cagatctttc tgatgattct gattttgatg
     1261 aaaaagcaaa actgaagtac tataaagaaa tagaagacag gcaaaagcta aagagaaaga
     1321 aagaagaaaa tagcactgaa gaacaggctc ttgaagatca aaatgcaaag agagctatta
     1381 cctatcaaat tgctaaaaat aggggactta ctcctaggag aaagaagatt gatcgcaatc
     1441 ccagagtgaa acacagagag aagttcagaa gagccaaaat tagaagaaga ggccaggttc
     1501 gtgaagttcg taaagaagag caacgttata gtggtgaatt atctggcatt cgtgcaggag
     1561 ttaaaaagag cattaagctt aaatgaagtt tttgcttagc ataaggtttt tggcagtttt
     1621 ggatcaataa atttttactt ttaactaaag tcattgtatt aatatataat actttaaatt
     1681 ttaaaaattc ttgtccacaa ggaaatttgt ctgggttatt ggacaattta taagaactat
     1741 gggagcaata tgaaggtgct tgagaaaaga gatgatgttg aagttttcca atattctgtt
     1801 gaagttttcc aatattaagt attagcttag ggaaatttca cagttcattg tggagtgtta
     1861 aacttagaac atgtgtaact tttcacataa agagaatgca tctttgacag ttatcttatt
     1921 tgtaaggcag cctataaaat agttctgaag tattttattt acctaactat aattattggg
     1981 ccagatactt gttaataaat gggcttaatg ttaacatgga
//
