LOCUS       NM_014388               8481 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens UTP25 small subunit processome component (UTP25),
            mRNA.
ACCESSION   NM_014388 NM_024998 XM_926295 XM_936838
VERSION     NM_014388.7
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 8481)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 8481)
  AUTHORS   Martin,B., Pappa,S., Diez-Villanueva,A., Mallona,I., Custodio,J.,
            Barrero,M.J., Peinado,M.A. and Jorda,M.
  TITLE     Tissue and cancer-specific expression of DIEXF is epigenetically
            mediated by an Alu repeat
  JOURNAL   Epigenetics 15 (6-7), 765-779 (2020)
   PUBMED   32041475
  REMARK    GeneRIF: Tissue and cancer-specific expression of DIEXF is
            epigenetically mediated by an Alu repeat.
REFERENCE   3  (bases 1 to 8481)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 8481)
  AUTHORS   Fragoza,R., Das,J., Wierbowski,S.D., Liang,J., Tran,T.N., Liang,S.,
            Beltran,J.F., Rivera-Erick,C.A., Ye,K., Wang,T.Y., Yao,L., Mort,M.,
            Stenson,P.D., Cooper,D.N., Wei,X., Keinan,A., Schimenti,J.C.,
            Clark,A.G. and Yu,H.
  TITLE     Extensive disruption of protein interactions by genetic variants
            across the allele frequency spectrum in human populations
  JOURNAL   Nat Commun 10 (1), 4141 (2019)
   PUBMED   31515488
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 8481)
  AUTHORS   Chen,S., Fragoza,R., Klei,L., Liu,Y., Wang,J., Roeder,K., Devlin,B.
            and Yu,H.
  TITLE     An interactome perturbation framework prioritizes damaging missense
            mutations for developmental disorders
  JOURNAL   Nat Genet 50 (7), 1032-1040 (2018)
   PUBMED   29892012
REFERENCE   6  (bases 1 to 8481)
  AUTHORS   Guan,Y., Huang,D., Chen,F., Gao,C., Tao,T., Shi,H., Zhao,S.,
            Liao,Z., Lo,L.J., Wang,Y., Chen,J. and Peng,J.
  TITLE     Phosphorylation of Def Regulates Nucleolar p53 Turnover and Cell
            Cycle Progression through Def Recruitment of Calpain3
  JOURNAL   PLoS Biol 14 (9), e1002555 (2016)
   PUBMED   27657329
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 8481)
  AUTHORS   Lei,H., Tang,J., Li,H., Zhang,H., Lu,C., Chen,H., Li,W., Xia,Y. and
            Tang,W.
  TITLE     MiR-195 affects cell migration and cell proliferation by
            down-regulating DIEXF in Hirschsprung's disease
  JOURNAL   BMC Gastroenterol 14, 123 (2014)
   PUBMED   25007945
  REMARK    GeneRIF: Colonic tissue from patients with Hirschsprung's disease
            showed lower expression levels of digestive-organ expansion factor
            (DIEXF).
            Publication Status: Online-Only
REFERENCE   8  (bases 1 to 8481)
  AUTHORS   Tao,T., Shi,H., Guan,Y., Huang,D., Chen,Y., Lane,D.P., Chen,J. and
            Peng,J.
  TITLE     Def defines a conserved nucleolar pathway that leads p53 to
            proteasome-independent degradation
  JOURNAL   Cell Res 23 (5), 620-634 (2013)
   PUBMED   23357851
REFERENCE   9  (bases 1 to 8481)
  AUTHORS   Castello,A., Fischer,B., Eichelbaum,K., Horos,R., Beckmann,B.M.,
            Strein,C., Davey,N.E., Humphreys,D.T., Preiss,T., Steinmetz,L.M.,
            Krijgsveld,J. and Hentze,M.W.
  TITLE     Insights into RNA biology from an atlas of mammalian mRNA-binding
            proteins
  JOURNAL   Cell 149 (6), 1393-1406 (2012)
   PUBMED   22658674
REFERENCE   10 (bases 1 to 8481)
  AUTHORS   Chen,J., Ruan,H., Ng,S.M., Gao,C., Soo,H.M., Wu,W., Zhang,Z.,
            Wen,Z., Lane,D.P. and Peng,J.
  TITLE     Loss of function of def selectively up-regulates Delta113p53
            expression to arrest expansion growth of digestive organs in
            zebrafish
  JOURNAL   Genes Dev 19 (23), 2900-2911 (2005)
   PUBMED   16322560
  REMARK    GeneRIF: characterization of the related zebrafish protein
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DA256510.1, AL022398.1, BC022964.1, AL022728.1 and CR749825.1.
            
            On Nov 22, 2018 this sequence version replaced NM_014388.6.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: CR749825.1, SRR1803613.7274.1
                                           [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000491415.7/ ENSP00000419005.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-59                DA256510.1         7-65
            60-199              AL022398.1         107115-107254
            200-239             AL022398.1         109192-109231
            240-290             AL022398.1         109887-109937
            291-2666            BC022964.1         257-2632
            2667-7760           AL022398.1         130835-135928
            7761-8450           AL022728.1         101-790
            8451-8481           CR749825.1         8390-8420
FEATURES             Location/Qualifiers
     source          1..8481
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q32.2"
     gene            1..8481
                     /gene="UTP25"
                     /gene_synonym="C1orf107; DEF; DIEXF; DJ434O14.5"
                     /note="UTP25 small subunit processome component"
                     /db_xref="GeneID:27042"
                     /db_xref="HGNC:HGNC:28440"
                     /db_xref="MIM:619663"
     exon            1..199
                     /gene="UTP25"
                     /gene_synonym="C1orf107; DEF; DIEXF; DJ434O14.5"
                     /inference="alignment:Splign:2.1.0"
     CDS             93..2363
                     /gene="UTP25"
                     /gene_synonym="C1orf107; DEF; DIEXF; DJ434O14.5"
                     /note="digestive-organ expansion factor homolog; UTP25
                     small subunit processor component"
                     /codon_start=1
                     /product="U3 small nucleolar RNA-associated protein 25
                     homolog"
                     /protein_id="NP_055203.4"
                     /db_xref="CCDS:CCDS1493.1"
                     /db_xref="GeneID:27042"
                     /db_xref="HGNC:HGNC:28440"
                     /db_xref="MIM:619663"
                     /translation="MGKRGSRSQSQLLNTLTKKQKKHLRDFGEEHPFYDRVSRKEAKP
                     QICQLSESSDSSDSESDSESEPQQVSGYHRLLATLKNVSEEEEEDEEEEEEEDSIVDD
                     AEMNDEDGGSDVSVEEEMAAESTESPENVALSADPEGKEDGEEPPGTSQTSPEEFTDA
                     KHESLFSLETNFLEEESGDNSSLKASQDPFLQHVNKELKEKAIQAVATNPKTTHELKW
                     PILGQLFFSSKFQKLETFKPPKDIDLKSLHLQKPLESTWTKTNSQFLSGPQKSSSPFT
                     PLQKELFLIMNSYRDLFYPERTALKNGEEIRHVYCLHVINHILKANAQVLGNNSRRRS
                     QKFGVGDDDDFRDQGLTRPKVLIVVPFREAALRVVQLFISLLEGDSKKKIIVSNKKRF
                     QGEYGSDPEERPPNLKRPEDYEAVFVGNIDDHFRIGVAILQRSIRLYAPFYSSDILIA
                     SPLGLRTIIGGEGEKKRDFDFLSSIELLIIDQADIYLMQNWEHVLHLMNHMNLLPLDS
                     HGVDFSRVRMWSLNNWSKYYRQTLLFGALQDAQINSVFNKYCVNMQGQVAVRNVPMTG
                     SISHVLVQLPHVFQRMEAENLASVIDARFNFFVNKILPQYRDAVMSHTLIYIPSYFDF
                     VRLRNYFKKEELNFTHICEYTQKSGVSRARHFFLQGEKQFLLFTERFHFYKRYTIKGI
                     RNLIFYELPTYPHFYSEICNMLRATNRGEEATWTCTVLYSKYDAQRLAAVVGVERAAQ
                     MLQSNKNVHLFITGEK"
     exon            200..239
                     /gene="UTP25"
                     /gene_synonym="C1orf107; DEF; DIEXF; DJ434O14.5"
                     /inference="alignment:Splign:2.1.0"
     exon            240..480
                     /gene="UTP25"
                     /gene_synonym="C1orf107; DEF; DIEXF; DJ434O14.5"
                     /inference="alignment:Splign:2.1.0"
     exon            481..654
                     /gene="UTP25"
                     /gene_synonym="C1orf107; DEF; DIEXF; DJ434O14.5"
                     /inference="alignment:Splign:2.1.0"
     exon            655..743
                     /gene="UTP25"
                     /gene_synonym="C1orf107; DEF; DIEXF; DJ434O14.5"
                     /inference="alignment:Splign:2.1.0"
     exon            744..1154
                     /gene="UTP25"
                     /gene_synonym="C1orf107; DEF; DIEXF; DJ434O14.5"
                     /inference="alignment:Splign:2.1.0"
     exon            1155..1374
                     /gene="UTP25"
                     /gene_synonym="C1orf107; DEF; DIEXF; DJ434O14.5"
                     /inference="alignment:Splign:2.1.0"
     exon            1375..1577
                     /gene="UTP25"
                     /gene_synonym="C1orf107; DEF; DIEXF; DJ434O14.5"
                     /inference="alignment:Splign:2.1.0"
     exon            1578..1760
                     /gene="UTP25"
                     /gene_synonym="C1orf107; DEF; DIEXF; DJ434O14.5"
                     /inference="alignment:Splign:2.1.0"
     exon            1761..1873
                     /gene="UTP25"
                     /gene_synonym="C1orf107; DEF; DIEXF; DJ434O14.5"
                     /inference="alignment:Splign:2.1.0"
     exon            1874..2119
                     /gene="UTP25"
                     /gene_synonym="C1orf107; DEF; DIEXF; DJ434O14.5"
                     /inference="alignment:Splign:2.1.0"
     exon            2120..8481
                     /gene="UTP25"
                     /gene_synonym="C1orf107; DEF; DIEXF; DJ434O14.5"
                     /inference="alignment:Splign:2.1.0"
     regulatory      8458..8463
                     /regulatory_class="polyA_signal_sequence"
                     /gene="UTP25"
                     /gene_synonym="C1orf107; DEF; DIEXF; DJ434O14.5"
                     /note="hexamer: ATTAAA"
     polyA_site      8481
                     /gene="UTP25"
                     /gene_synonym="C1orf107; DEF; DIEXF; DJ434O14.5"
                     /note="major polyA site"
ORIGIN      
        1 gcagtcagcg agcccacgtg cttgtgttga ctggacaact tcctggtgga aaaccgcgac
       61 tcttgcaagt gggcaaactt gacgttttcg ctatgggcaa acgcgggagc cggagccaga
      121 gccagctact caacacccta actaaaaagc agaagaaaca tcttcgagat ttcggcgagg
      181 agcatccctt ctatgacagg gtttccagaa aggaagcaaa gccacagatt tgtcaactgt
      241 cagagagttc agattcttca gattctgaaa gcgactcaga gagtgaacca caacaagttt
      301 ctggctacca cagactactt gctacattaa agaatgtttc tgaggaagaa gaggaagatg
      361 aggaggagga agaggaagaa gacagtattg tagatgatgc agaaatgaac gatgaagatg
      421 gtggtagcga tgtcagtgtg gaagaagaga tggctgcaga gtctactgaa agtccagaga
      481 atgtagcttt atctgctgac cctgagggaa aagaagatgg ggaagagcca ccgggcacat
      541 cacaaacatc ccccgaagag ttcacagatg caaaacacga gtcactgttc agcctggaaa
      601 ccaattttct ggaagaggaa agtggagaca actcttcttt gaaagcctct caagatccat
      661 ttcttcaaca tgtgaacaaa gaactgaaag aaaaagcaat tcaggctgtt gccacaaatc
      721 ccaaaactac ccacgagctt aaatggccta ttctgggcca gcttttcttt tcctctaagt
      781 ttcagaagtt ggaaacattt aaacccccaa aggatattga cttaaagtca cttcatctcc
      841 agaagcctct ggaatccacc tggactaaga ccaacagcca gttcctatct ggtccccaaa
      901 aatcaagcag cccattcacc cccctccaga aagaactctt cttaattatg aattcttacc
      961 gggacctgtt ctacccggaa aggactgctc tgaagaacgg ggaagagatc cgccatgtgt
     1021 attgcctgca tgtgataaat cacatcctca aagccaatgc ccaggtgctt ggcaacaata
     1081 gcagacgccg aagccagaag tttggagtgg gtgatgatga tgacttcaga gaccaagggt
     1141 taacaaggcc caaggtactg atagtggtgc cattccggga agctgctttg cgggtggtgc
     1201 agctcttcat cagcctcctc gagggtgaca gcaagaagaa aatcattgtg agcaacaaaa
     1261 agaggtttca gggagaatat ggatcagatc ccgaggagag accacccaac ttgaagaggc
     1321 ctgaggatta tgaagccgta tttgtgggca atattgatga ccacttcagg attggagtgg
     1381 caatacttca gagaagcatc cgactctatg ccccgtttta ctcctcggat atcctcattg
     1441 cttcccccct gggcttgagg accatcattg gtggagaagg agagaagaag agagattttg
     1501 actttctgtc ttctatcgag cttctcatca ttgatcaagc tgacatttac ctgatgcaga
     1561 actgggagca tgtcctgcat ttgatgaatc acatgaacct actacccctg gactcacatg
     1621 gggtagactt ttctcgagtg cggatgtgga gcctcaataa ttggtccaag tactatcgcc
     1681 agacactgct atttggggcc cttcaggatg cccagatcaa ctcagtgttc aacaagtact
     1741 gtgtcaacat gcaaggccag gtggccgtga ggaatgtccc aatgacaggc tctatcagtc
     1801 atgtcctggt gcagctccca catgtcttcc agaggatgga agctgaaaac ctagcttcag
     1861 tgattgatgc caggtttaac ttttttgtga acaagatttt gccacagtat cgtgatgcag
     1921 tcatgtctca cacgctcatc tatatcccct cctactttga cttcgtgcgt cttcgaaatt
     1981 acttcaagaa ggaggaattg aattttaccc acatctgcga gtacacgcag aagtctggtg
     2041 tctccagggc cagacacttc ttccttcaag gagagaaaca gtttctactt ttcacagagc
     2101 gcttccattt ctacaaaagg tatacaataa aaggcatcag gaacctgatt ttctatgaac
     2161 tgccgacata tccacacttt tacagtgaaa tctgtaatat gctgagagcc accaacagag
     2221 gagaagaggc cacgtggacc tgcactgttc tctactccaa atatgatgcc cagaggttag
     2281 ctgccgtggt tggtgtggag cgggcggcac agatgctaca gtccaacaag aatgtccacc
     2341 tcttcattac tggagaaaaa tgaaattttg ttgggcagga agtggtattt ggcatgatac
     2401 ataatgtttg attctatgcc atttggaccc aattctgatt acttacagaa gaaggactga
     2461 tacaaagaaa gtgcatgagg caatgtcagt attatctgac atctttcttt tcaggtcatg
     2521 tgtccctgaa aagttaaatg taaaccagat tttggtaaat cccatctttc agaagtgaag
     2581 agggggctag aaggactctg agaagttggt agaagaaaac tcccacttgt gaatattttt
     2641 gtgagacata aattctttta ttacgattta cctctaattt attacactta gtaaattctt
     2701 ccagattttt ctatttgttt gacacttcct taaagtaagg aatacacatt gcttgcgaga
     2761 actggttatg agacattgga atacttcttg ctgctacatg tcatcttaat tttggatggc
     2821 atgggttttg taaaacttat tctgccccag ccaaactttt ttgaaacctt aaatagtcta
     2881 ccttaattca gcctagaaga gtacattgat ttactgatct tttttcatat tcataatact
     2941 aaatgtttta gttttgttca aatatatgct taaaatcacg ttatttaaaa aacacatcag
     3001 ctctgtctca agaagtaatt ttgttgaaac tccatgttaa aatatccatc ttcaacagta
     3061 gtgtcttcat aataactagt cattttttca gtcataaaca gatgcaaata aaaaggaaat
     3121 tacactttta aaaacatttt tattttgaaa cattctcaaa cagaaaaatt ccaagtacag
     3181 aacctgaacc atttgagagt gagttgccaa cccagtgggc ctatcacctt taaatacttt
     3241 agtatatatt tcctgtaaac aattaagggt attgtttgtg attaggaatg ccccaccaat
     3301 aaggataatg tgaatatttc agaatccaaa aaaattcgaa acacgtctgg tcccaagcat
     3361 ttcagataag agatattcaa ctcatcctag tatggactcg tagtttcttc ttttattcaa
     3421 tgggttacgg tttgttacat cattatttct ttagatgcgt aactggtctc aaatatggcc
     3481 gctgggagca ccttcaggtt agcccctgtg tacttttgac atgtccccca tctacttggg
     3541 cactgctgta ttttttgaca atgagacatt ccaggtttct ctactccagc cctgcttgct
     3601 tttagtagga aattattata aaaggttaga ttggagtgct tactattgtg gtgccactca
     3661 tcccaggctc agtggtcaga acttgggaat tgtgtacatg tatgcacaca catatgtaca
     3721 cacgttgtct aaatttgctt cacattaata tctaaattta ctttcatatc catatattga
     3781 aaaccatgaa ttcacaccag tacctccaat tctagtccaa caacacagga ttgcttctca
     3841 ttttctttcc atattgataa ctcctttctc agacagtggc tcccattatc ctcaatgtaa
     3901 taacccatga ttggtacaga ttttttttat ccttgggcac gcttaaaatt acttagcaaa
     3961 aacaaaaagt aaaatcagtt ttgaagtaat atttctgcta aatatttaga catttttact
     4021 tctttttctt cagcatggta agtaaaacca tttattccat atttagatgg ttttctaaat
     4081 ttcagaaaat ttagttagat aaaagccgac cgaacccatg ctacaaagaa ctttttgtat
     4141 ctataggcat gccctgtggt tactggcgta attgtgctgc tgtttatcat agatcctgta
     4201 tattatgaga ataagaaatg agtttattta cctcattcag aaatgtgagg cgaagggact
     4261 gtaattacct ggatcttttt tttttttttt gagatggagt ctcgctctgt tgcccaggct
     4321 ggagtacact ggcatgatct tggcttactg caatctgtgc ctcccgagtt caagcgattc
     4381 tcgtgcctcc gcctcccaag tagctgggac tacaggcgca tgccaccatg cacagctaat
     4441 tttttatatt tttagtagag atggggtttt gccatgttgg ccaggctggt ctcaaactct
     4501 tgacctcaag tgatctgccc acctcagcct cccaaagtgc tggggttaca ggcctgagcc
     4561 gccacgcctg gccaattacc tacatctttt tctactgcca tattcttttg cctgtgaatt
     4621 gtagttcatc tcgtggtttc cattattact attcacacga ctcccaaatc tccagcttct
     4681 ctggctctcc actcacatgt gagtctggat ttcaaatcca tgatgtagcc ccagaaataa
     4741 ccattttatt aagcacccct agtgattttc atgctggcat agagccaaac ccagccaact
     4801 gcttcttgcc tgcagagaac actgaggatt tcaagtgtga acaaagtagt gttgctttgt
     4861 tcctggctca gcacctgaaa agaaggtaag cctctgcagt tagccctggc tccttagtgc
     4921 attgcagagt ggagtctctg caatggtttt attaaaagga tgccttgaag atctggtctc
     4981 tctcaacaca caataagcga gaagagaggc tactgaaata cggatgcgtg agctggaatt
     5041 acacactacc ttgatgttaa caaggctcat ttgcagcaag caagtgccta tatagggtct
     5101 gaaatataga caaaggatgg tcccaatcct ggaaacagtg gaattaaaag gtatggaaag
     5161 gaacttaccc agaaagtaac acttttaaat gttttttctt ttcccatagt taaaacaacc
     5221 agcttagcac ttttcttttt gagagagaaa aagctttgaa tcgtggatgc ttctcacagc
     5281 tggctgcacc acgtgcagtg ttcaaaaaac aagaacaagc taatcataga gaaccagcag
     5341 cagctaaaca gccctctgct tgcttccaaa gggcttataa ttgagcacag atggtcctag
     5401 tggagatggg gaatgtgtcc ctgctgactc ctcatacccc agaggaccaa ggggggctca
     5461 tgaaggctct cagccctgat tgtgccctcg tgagggcaag gagctatgct gctgaaggag
     5521 gaaagggaaa ggcaggtggg gccagaccct attggccatc tgaccagcct tcccaagccc
     5581 acgtgagcag atctagggtc tcaagattac agaaggcctg gggtgaggga gcaagagttg
     5641 gaagttcttt atagttgtct gaagagcctc attgtccaac tgcaggggcc tgaggtgccc
     5701 aaagcttcgt ggaaaagtaa tgtcagtgga atgctcagaa gtggctcttt tcagggcacg
     5761 gcttctgagg agcgtggggc caccacagct agccctccct ccgtctagcc atcctctcct
     5821 tccagtccct ttcccatctt ttctctcaaa ggagcatggt agtgatcttc attaccaaat
     5881 ttctactcca cacttatttt aaaaagcttt tctgaaagcc tggctacata gaattctaaa
     5941 cagatttcag tcaactttta attagagtca atgaatgggg agtaaataca cagataatcc
     6001 aaaattgatg taagcattgg aaggggaaag agggaacgct tctttccctc tgggcttggt
     6061 catttcctcc caagcaaacc ccgcgacgtt cagccgtctt cctcctatgc cacgtgctct
     6121 caccagaact gcagcaaaac tgcattttat gtcctgtgtc taaagctaaa cacatgttcc
     6181 tgtctacttt tgctttgttc ctgtttccct tctgtgagga ccttcccctc ctcagatgtg
     6241 gggagttgcc gcctccactt gcattacatg tatttcagag taggtcctag gctcccctta
     6301 cacctctggt cacgttgcca ttattcctat ggtagataaa ggggatgaga aagaacagag
     6361 ctccaggcct ttttcaaaca aactggtttt ctcagtatag ccctatgctc aaaaggagtg
     6421 aggacaggta tgtgactgcc ataaggagct gtttgctttg cacagagaaa tctaatcttt
     6481 ctcctgctgg gcagctcagt acagatgtcc cctcactgct ggaagaaaca cctgcccttg
     6541 cttgttctcc tgatggcccc tcacagtcag gtgtgggatg gcacatttct aggtgctcct
     6601 cgccgagctg tcatgggctt cagtcttggg cctctgcagc tggctgtgac caggtggaaa
     6661 ctgtagcctt ggctgaccca gagaaggaaa ggaggcagtc tgccgcttgg ctgatttagg
     6721 agttgtgctg aattcctgcc catctgttct cccagctgag ccaaggccaa agctgtctac
     6781 cttttgccaa cctaaggaat gacacagagc atggagcacc atcactgaaa catctgcccc
     6841 agtgccctgc caccttcgtc ctcactgacc tctgcagcct ctctcatctg ccagttttga
     6901 ttccgcaagg agaggtggcc ctgggctcac agctggtgtt tgtccacaga tgttcatggg
     6961 tttctttgtg ttctctcatt ttttcaaagc tgggtgttgg gaccaacatc accactgaca
     7021 ttctgtggct ctaaacaagt cctcacgacc acttctcagt tttctcatct ttatgaagta
     7081 tggagtaatc cccactagcc ttatagaggg actgtgtgag aagggaagag actgctattg
     7141 tttgccctat atccacctac ttccctagtt ccagaacgct ggactttaat gagataacaa
     7201 agtacctagt aaaaacactg catcattttc catcccccac cccttgcagt aaaatgtggc
     7261 ccatgagaca gaagcactaa ctactgagca ggacttctag gggagttctt taaaactcag
     7321 aggagcacca cttttacctt ctgctcttcc ctttttcctg cctggaacgc agaagtgatg
     7381 gctgaagctc ctgaggctat aagctctgta cgtaggagag tggtgaagaa aggagcttgg
     7441 ttctgcaagg atgttgtaga gctgccatac cagtcctgca tggtattcct gtgcactact
     7501 gttacgtgaa cacacaaaca cctaatttgt ttaagccatt aggccaggcc tctattagcc
     7561 attcctgact gatacagaag acaaaaatgg catcacagac tcctgaactc caaagacact
     7621 gcctattctt tcgtctgttc ttggcaagca ccaacattga gactgtactt cagggttgat
     7681 gctggccatt tggtggcgtg aggagtgggc actcacatgt ctctgctagc agttctgacg
     7741 tgtccattcc acactggatc catagaacga gggaacacaa gtgtcttctc ataagattta
     7801 tagaaacagt gatcgttgca gaaaaataat tagcaagaga acagacttca gctctctgaa
     7861 ggctgatgac cacctgtttc tcatctcttc tagtgtatgt caaagctaaa ttaggtcaaa
     7921 taggaaataa gtcagaatcc ccaattcgat agaaacttac aggtcttgtg atctaatctg
     7981 ccacttgatc cgtgaattac ctataggtca tccctaagag gtggcctcca gcttctgctt
     8041 gaattccttc aaggatgggg tgctcattgt ggcttttcta atcatctctg attgttagaa
     8101 acactgtgaa acttttatcc atcagtcctg tttctgaagc tgtacggtac aaattttttt
     8161 tttccccact taaggctcaa ctattggaat acatctacca tgtctcctat gaaacttgct
     8221 tctccaggcc aatcatcctt acttccttaa actttttttt ttcctgaaaa gttattcttt
     8281 taatcttatt aaaaaagcaa cccatgccca ttccacaaat acaagtgaaa tagtgaaaaa
     8341 caaaaatcaa actacatcta tttggtgatc attattaatg tcttatgttt cctcccagat
     8401 tgttttctgc atgaataata accaacaatg tgtgtgtatg tatatatatg cttttgcatt
     8461 aaaaggtggt tttgaaggta a
//
