LOCUS       NM_032334               3672 bp    mRNA    linear   PRI 23-MAR-2024
DEFINITION  Homo sapiens UTP23 small subunit processome component (UTP23),
            mRNA.
ACCESSION   NM_032334
VERSION     NM_032334.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3672)
  AUTHORS   E,F., Qian,L., Tang,J. and Tong,Z.
  TITLE     Cytoplasmic expression of UTP23 promotes colorectal cancer
            progression
  JOURNAL   Cell Mol Biol (Noisy-le-grand) 70 (1), 239-245 (2024)
   PUBMED   38372088
  REMARK    GeneRIF: Cytoplasmic expression of UTP23 promotes colorectal cancer
            progression.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3672)
  AUTHORS   Zhang,S., Bai,X., Li,F., Ni,C., Li,Y., Che,N., Zhao,N., Zhao,X. and
            Liu,T.
  TITLE     UTP23 Functions in Breast Cancer Progression and Predicts Poor
            Prognosis of Luminal a Breast Cancer
  JOURNAL   Clin Breast Cancer 24 (1), e20-e30.e6 (2024)
   PUBMED   37880005
  REMARK    GeneRIF: UTP23 Functions in Breast Cancer Progression and Predicts
            Poor Prognosis of Luminal a Breast Cancer.
REFERENCE   3  (bases 1 to 3672)
  AUTHORS   Li,J., Xie,S., Zhang,B., He,W., Zhang,Y., Wang,J. and Yang,L.
  TITLE     UTP23 Is a Promising Prognostic Biomarker and Is Associated with
            Immune Infiltration in Breast Cancer
  JOURNAL   Crit Rev Eukaryot Gene Expr 34 (3), 1-15 (2024)
   PUBMED   38305284
  REMARK    GeneRIF: UTP23 Is a Promising Prognostic Biomarker and Is
            Associated with Immune Infiltration in Breast Cancer.
REFERENCE   4  (bases 1 to 3672)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 3672)
  AUTHORS   Fu,Z., Wang,C., Chen,Y., Zhang,X., Wang,X. and Xie,X.
  TITLE     Down-regulation of UTP23 promotes paclitaxel resistance and
            predicts poorer prognosis in ovarian cancer
  JOURNAL   Pathol Res Pract 215 (11), 152625 (2019)
   PUBMED   31540773
  REMARK    GeneRIF: Our findings elucidated a previously unknown function for
            UTP23 in regulating paclitaxel sensitivity and UTP23 could serve as
            a potential prognostic predictor for ovarian cancer
REFERENCE   6  (bases 1 to 3672)
  AUTHORS   Wells,G.R., Weichmann,F., Sloan,K.E., Colvin,D., Watkins,N.J. and
            Schneider,C.
  TITLE     The ribosome biogenesis factor yUtp23/hUTP23 coordinates key
            interactions in the yeast and human pre-40S particle and hUTP23
            contains an essential PIN domain
  JOURNAL   Nucleic Acids Res 45 (8), 4796-4809 (2017)
   PUBMED   28082392
  REMARK    GeneRIF: yUtp23/hUTP23 could therefore be central to the
            coordinated integration and release of ES6 binding factors and
            likely plays a pivotal role in remodeling this pre-rRNA region in
            both yeast and humans. Finally, studies using RNAi-rescue systems
            in human cells revealed that intact PIN domain and Zinc finger
            motifs in human hUTP23 are essential for 18S rRNA maturation.
REFERENCE   7  (bases 1 to 3672)
  AUTHORS   Castello,A., Fischer,B., Eichelbaum,K., Horos,R., Beckmann,B.M.,
            Strein,C., Davey,N.E., Humphreys,D.T., Preiss,T., Steinmetz,L.M.,
            Krijgsveld,J. and Hentze,M.W.
  TITLE     Insights into RNA biology from an atlas of mammalian mRNA-binding
            proteins
  JOURNAL   Cell 149 (6), 1393-1406 (2012)
   PUBMED   22658674
REFERENCE   8  (bases 1 to 3672)
  AUTHORS   Hoareau-Aveilla,C., Fayet-Lebaron,E., Jady,B.E., Henras,A.K. and
            Kiss,T.
  TITLE     Utp23p is required for dissociation of snR30 small nucleolar RNP
            from preribosomal particles
  JOURNAL   Nucleic Acids Res 40 (8), 3641-3652 (2012)
   PUBMED   22180534
REFERENCE   9  (bases 1 to 3672)
  AUTHORS   Bleichert,F., Granneman,S., Osheim,Y.N., Beyer,A.L. and
            Baserga,S.J.
  TITLE     The PINc domain protein Utp24, a putative nuclease, is required for
            the early cleavage steps in 18S rRNA maturation
  JOURNAL   Proc Natl Acad Sci U S A 103 (25), 9464-9469 (2006)
   PUBMED   16769905
REFERENCE   10 (bases 1 to 3672)
  AUTHORS   Takagi,M., Absalon,M.J., McLure,K.G. and Kastan,M.B.
  TITLE     Regulation of p53 translation and induction after DNA damage by
            ribosomal protein L26 and nucleolin
  JOURNAL   Cell 123 (1), 49-63 (2005)
   PUBMED   16213212
  REMARK    Erratum:[Cell. 2005 Nov 4;123(3):536-7]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BP231814.1, AK315770.1, AP002905.2 and AC087350.3.
            
            On Nov 22, 2018 this sequence version replaced NM_032334.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803613.194965.1,
                                           SRR1803611.114302.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000309822.7/ ENSP00000308332.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-35                BP231814.1         22-56
            36-830              AK315770.1         1-795
            831-1209            AP002905.2         5330-5708           c
            1210-3672           AC087350.3         190902-193364       c
FEATURES             Location/Qualifiers
     source          1..3672
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="8"
                     /map="8q24.11"
     gene            1..3672
                     /gene="UTP23"
                     /gene_synonym="C8orf53"
                     /note="UTP23 small subunit processome component"
                     /db_xref="GeneID:84294"
                     /db_xref="HGNC:HGNC:28224"
     exon            1..268
                     /gene="UTP23"
                     /gene_synonym="C8orf53"
                     /inference="alignment:Splign:2.1.0"
     CDS             81..830
                     /gene="UTP23"
                     /gene_synonym="C8orf53"
                     /note="UTP23, small subunit (SSU) processome component,
                     homolog"
                     /codon_start=1
                     /product="rRNA-processing protein UTP23 homolog"
                     /protein_id="NP_115710.2"
                     /db_xref="CCDS:CCDS6320.1"
                     /db_xref="GeneID:84294"
                     /db_xref="HGNC:HGNC:28224"
                     /translation="MKITRQKHAKKHLGFFRNNFGVREPYQILLDGTFCQAALRGRIQ
                     LREQLPRYLMGETQLCTTRCVLKELETLGKDLYGAKLIAQKCQVRNCPHFKNAVSGSE
                     CLLSMVEEGNPHHYFVATQDQNLSVKVKKKPGVPLMFIIQNTMVLDKPSPKTIAFVKA
                     VESGQLVSVHEKESIKHLKEEQGLVKNTEQSRRKKRKKISGPNPLSCLKKKKKAPDTQ
                     SSASEKKRKRKRIRNRSNPKVLSEKQNAEGE"
     exon            269..443
                     /gene="UTP23"
                     /gene_synonym="C8orf53"
                     /inference="alignment:Splign:2.1.0"
     exon            444..3672
                     /gene="UTP23"
                     /gene_synonym="C8orf53"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3651..3656
                     /regulatory_class="polyA_signal_sequence"
                     /gene="UTP23"
                     /gene_synonym="C8orf53"
                     /note="hexamer: ATTAAA"
     polyA_site      3672
                     /gene="UTP23"
                     /gene_synonym="C8orf53"
                     /note="major polyA site"
ORIGIN      
        1 ggcattgagg gtactggggc gtgcgtgagg cgtttactga tgcttcctgg tccggtggcc
       61 tcggtcccgg taagccaggc atgaagatca caaggcagaa acatgccaag aagcatcttg
      121 gcttcttccg caacaacttc ggagtccgcg agccgtacca gatcctgctg gacggcacct
      181 tctgtcaggc ggcgctgcgg ggccgcatcc agctgcggga gcagctgccc cgctacctca
      241 tgggggagac gcagctgtgc accacaagat gtgtgttaaa agagctagaa acattgggaa
      301 aggacttata tggggcaaaa ctgattgcac aaaaatgcca agttcgaaat tgtcctcatt
      361 tcaagaatgc agtgagtgga tcagaatgtc tgctttccat ggttgaagag ggaaatcctc
      421 atcattattt tgtggcaaca caggatcaga atttgtctgt gaaagtaaaa aagaagcctg
      481 gagttcctct catgtttatt attcagaaca ctatggtttt ggacaaacct tctcccaaaa
      541 caattgcctt tgtaaaagca gtggagtcag gtcagcttgt ctcagtgcat gagaaagaaa
      601 gtatcaaaca tctcaaagag gaacagggtt tagtgaaaaa cactgaacag agtagaagaa
      661 aaaagcgcaa gaaaataagt ggtcccaatc ctcttagttg tttgaagaaa aagaaaaagg
      721 caccggacac acaatcatct gcttctgaaa agaaaagaaa aagaaaaaga attcggaaca
      781 gatctaaccc aaaagtactt tctgagaagc agaatgcaga aggagaatga atcctttgga
      841 tactttcaag gacattcaaa tgtgaaaatg aattttttac aactagaagt atttataata
      901 aaagaccaaa cttatttttg taaatgaacc catatgcttt agctaaaatt aattataaaa
      961 taaaaacagt gaccagtcta gccagcatgg caaaacccca tctctactaa aatacaaaaa
     1021 ttagctgggc atgatggtgc acagttgtaa ttccagctac tcaggaggct gaggcatgag
     1081 aatcgcttga acctgggagg cagagattgc agtgagccca gttcgtgtca cttcactcca
     1141 gcctgggcaa cagagtgaga acatgtctca aaaaaaaaat aaaaacagtg aatgggtgta
     1201 ggtgtgatgg aattcacttt acttactaaa tggtttcggg aggttgtttc tccaggtaaa
     1261 attgtcgcct ctctggtccc attcccacct tcaaacatta tatgcaaaca gttttaaaaa
     1321 atcttacagt tctaaaaggc ttgtgacaaa aaaagaggca gtccctcttt cacattgaca
     1381 gaagaaactt cctctttcaa ttctagtagt tgaagaattt atatttccaa attgtatgat
     1441 tataccgcta ctttttgata catcaattat ttattgactt cctactagaa agagtgaaat
     1501 tttgcccatt tatactgcac catttttcca gtatatgaat attttactct ttgtacatca
     1561 gaaactcagt attttcatta ttatgactag agtttttttg tttgtttgtt tgagttctac
     1621 ttgtccaata aggatgatga ttttctttta gatgtaaatg ttaacttcaa tagcaagaat
     1681 tcaaaaataa tattctcttt gagattgact gtgaatgtta ttgaaaagtg tctaaattag
     1741 tctgaggatc aatgagggtc aattcagtta ggaattgaat aatgaaacgt gtctctctga
     1801 attcccccgg caattgtttt agtcatttat caggccaaaa ttaaaatgtt tttgtactac
     1861 aagatggaag tataaaatta ttggacaagt gaaatcgtat cagtagttcc tgactgacag
     1921 cttctggagc cacactagag cagtgattct cagtctaaca ttaggttatc atgatgacgt
     1981 atgagtaaat tcttaatggt taaatgtgag acagttcaca tttattccca tagaaatgtc
     2041 attctcattt gaattcagag atacttcttt gctggaagtt ggaattatag ctttacacca
     2101 aggagtgaca cgtagactaa tctggcaagc caaggtagtg tttggattgc aatgtcatga
     2161 ttctatttta aattcttgat ggtagaaaca tttttaataa ggaaggtaaa aatactggaa
     2221 aaaagtgaat agtgtaggtt ttgtgaggaa agttaacatt tgtcaatgac aagcattaag
     2281 gccacctaat aaagtgtaga caaagtgata aatgaaatat acactgatga tactcatttc
     2341 aatatgctaa aatacattaa atttaggtat tactcttaat ctatttctac ttagtcagtg
     2401 ctatctgatt acctgttaat agcatctgaa ctggagagct ggaaaaatcc acttttttat
     2461 gaagcagtaa ttatagaagt actaaaaatt acaatgtatt agtaagttta atattttgac
     2521 agggcatggt ggctcacacc tgtaatccca gcactttggg aggccgaggc tggcagatca
     2581 caaaattaag agatcaagac catcctggcc aacatggtga aaccctgtct gtactaaaaa
     2641 tacaaaaatt agctgggtgt ggtggtgtgc gcctgtagtc ccagctactc gggaggctga
     2701 ggcaggagaa tcgcttgaac ccaggaggcg gaggttgcag tgagccaaga tcatgccact
     2761 gcactccagc ctggtgagag agtgaaaccc cgtctcaaaa ataaataaat aaataagttt
     2821 actattttaa aactggttaa tcatttatgt attttgccag taaaattact ttaaaagata
     2881 ttttaacaaa agtctcatat ccttgtactt cagttttttt gtgtgtgaat actatcccta
     2941 taccactacc cctaaaacct cagaattatt tgctttattt tttcatacaa cttggggaag
     3001 ggaaccatgg gagtatgcac atgggatcat aatccattct gtggtttgga aaaagaaaat
     3061 gttaacctct gctttagagg gtagctacta gctttgttgg ggataaaagt gtaatacatg
     3121 cacttttgaa ctctgaaagt ttgccaatct gaaaaggggt gtttctgaag accactatct
     3181 tttacgaaca cttaaaaata agtgtttgca gttgtgtatg ggcacgatac tgtattcttt
     3241 acatttttat ggccctacag ctacttctta tccctgcaag tatataaatt aaaaccaagt
     3301 cactttagaa cagctttgaa actagagttt caaaggtaaa aggatctcat gtttctgaat
     3361 ctgcgtaaag caagatggct gtgatttgac aggtttaatt gctagttttt tataggtgga
     3421 tagaaatgaa tagtttggag tctttaaaat gttttaaaaa atgtttgctt actatctata
     3481 tatatgacat tattcccaat tagttttata tctccaagat atatatatgt atataggtat
     3541 atacacatat gtatatatac atagtctata tattctatat aagaatatat tccaataaga
     3601 atatattcca tacgggaata tattagtcat tgatgtattt tgccggtaaa attaaaagat
     3661 attttaacaa aa
//
