LOCUS       NM_016001               1876 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens UTP18 small subunit processome component (UTP18),
            mRNA.
ACCESSION   NM_016001
VERSION     NM_016001.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1876)
  AUTHORS   Singh,S., Vanden Broeck,A., Miller,L., Chaker-Margot,M. and
            Klinge,S.
  TITLE     Nucleolar maturation of the human small subunit processome
  JOURNAL   Science 373 (6560), eabj5338 (2021)
   PUBMED   34516797
REFERENCE   2  (bases 1 to 1876)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 1876)
  AUTHORS   Fasci,D., van Ingen,H., Scheltema,R.A. and Heck,A.J.R.
  TITLE     Histone Interaction Landscapes Visualized by Crosslinking Mass
            Spectrometry in Intact Cell Nuclei
  JOURNAL   Mol Cell Proteomics 17 (10), 2018-2033 (2018)
   PUBMED   30021884
REFERENCE   4  (bases 1 to 1876)
  AUTHORS   Baltz,A.G., Munschauer,M., Schwanhausser,B., Vasile,A.,
            Murakawa,Y., Schueler,M., Youngs,N., Penfold-Brown,D., Drew,K.,
            Milek,M., Wyler,E., Bonneau,R., Selbach,M., Dieterich,C. and
            Landthaler,M.
  TITLE     The mRNA-bound proteome and its global occupancy profile on
            protein-coding transcripts
  JOURNAL   Mol Cell 46 (5), 674-690 (2012)
   PUBMED   22681889
REFERENCE   5  (bases 1 to 1876)
  AUTHORS   Castello,A., Fischer,B., Eichelbaum,K., Horos,R., Beckmann,B.M.,
            Strein,C., Davey,N.E., Humphreys,D.T., Preiss,T., Steinmetz,L.M.,
            Krijgsveld,J. and Hentze,M.W.
  TITLE     Insights into RNA biology from an atlas of mammalian mRNA-binding
            proteins
  JOURNAL   Cell 149 (6), 1393-1406 (2012)
   PUBMED   22658674
REFERENCE   6  (bases 1 to 1876)
  AUTHORS   Beausoleil,S.A., Villen,J., Gerber,S.A., Rush,J. and Gygi,S.P.
  TITLE     A probability-based approach for high-throughput protein
            phosphorylation analysis and site localization
  JOURNAL   Nat Biotechnol 24 (10), 1285-1292 (2006)
   PUBMED   16964243
REFERENCE   7  (bases 1 to 1876)
  AUTHORS   Bernstein,K.A., Gallagher,J.E., Mitchell,B.M., Granneman,S. and
            Baserga,S.J.
  TITLE     The small-subunit processome is a ribosome assembly intermediate
  JOURNAL   Eukaryot Cell 3 (6), 1619-1626 (2004)
   PUBMED   15590835
REFERENCE   8  (bases 1 to 1876)
  AUTHORS   Beausoleil,S.A., Jedrychowski,M., Schwartz,D., Elias,J.E.,
            Villen,J., Li,J., Cohn,M.A., Cantley,L.C. and Gygi,S.P.
  TITLE     Large-scale characterization of HeLa cell nuclear phosphoproteins
  JOURNAL   Proc Natl Acad Sci U S A 101 (33), 12130-12135 (2004)
   PUBMED   15302935
REFERENCE   9  (bases 1 to 1876)
  AUTHORS   Yokoyama,A., Wang,Z., Wysocka,J., Sanyal,M., Aufiero,D.J.,
            Kitabayashi,I., Herr,W. and Cleary,M.L.
  TITLE     Leukemia proto-oncoprotein MLL forms a SET1-like histone
            methyltransferase complex with menin to regulate Hox gene
            expression
  JOURNAL   Mol Cell Biol 24 (13), 5639-5649 (2004)
   PUBMED   15199122
REFERENCE   10 (bases 1 to 1876)
  AUTHORS   Scherl,A., Coute,Y., Deon,C., Calle,A., Kindbeiter,K.,
            Sanchez,J.C., Greco,A., Hochstrasser,D. and Diaz,J.J.
  TITLE     Functional proteomic analysis of human nucleolus
  JOURNAL   Mol Biol Cell 13 (11), 4100-4109 (2002)
   PUBMED   12429849
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BG723023.1, BC025276.1, AY007138.1 and BM548967.1.
            
            On Nov 22, 2018 this sequence version replaced NM_016001.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.274086.1,
                                           SRR3476690.838089.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000225298.12/ ENSP00000225298.7
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-14                BG723023.1         23-36
            15-740              BC025276.1         1-726
            741-1872            AY007138.1         221-1352
            1873-1876           BM548967.1         8-11                c
FEATURES             Location/Qualifiers
     source          1..1876
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q21.33"
     gene            1..1876
                     /gene="UTP18"
                     /gene_synonym="CGI-48; WDR50"
                     /note="UTP18 small subunit processome component"
                     /db_xref="GeneID:51096"
                     /db_xref="HGNC:HGNC:24274"
                     /db_xref="MIM:612816"
     exon            1..381
                     /gene="UTP18"
                     /gene_synonym="CGI-48; WDR50"
                     /inference="alignment:Splign:2.1.0"
     CDS             40..1710
                     /gene="UTP18"
                     /gene_synonym="CGI-48; WDR50"
                     /note="WD repeat domain 50; WD repeat-containing protein
                     50; UTP18, small subunit (SSU) processome component,
                     homolog"
                     /codon_start=1
                     /product="U3 small nucleolar RNA-associated protein 18
                     homolog"
                     /protein_id="NP_057085.2"
                     /db_xref="CCDS:CCDS42362.1"
                     /db_xref="GeneID:51096"
                     /db_xref="HGNC:HGNC:24274"
                     /db_xref="MIM:612816"
                     /translation="MPPERRRRMKLDRRTGAKPKRKPGMRPDWKAGAGPGGPPQKPAP
                     SSQRKPPARPSAAAAAIAVAAAEEERRLRQRNRLRLEEDKPAVERCLEELVFGDVEND
                     EDALLRRLRGPRVQEHEDSGDSEVENEAKGNFPPQKKPVWVDEEDEDEEMVDMMNNRF
                     RKDMMKNASESKLSKDNLKKRLKEEFQHAMGGVPAWAETTKRKTSSDDESEEDEDDLL
                     QRTGNFISTSTSLPRGILKMKNCQHANAERPTVARISSVQFHPGAQIVMVAGLDNAVS
                     LFQVDGKTNPKIQSIYLERFPIFKACFSANGEEVLATSTHSKVLYVYDMLAGKLIPVH
                     QVRGLKEKIVRSFEVSPDGSFLLINGIAGYLHLLAMKTKELIGSMKINGRVAASTFSS
                     DSKKVYASSGDGEVYVWDVNSRKCLNRFVDEGSLYGLSIATSRNGQYVACGSNCGVVN
                     IYNQDSCLQETNPKPIKAIMNLVTGVTSLTFNPTTEILAIASEKMKEAVRLVHLPSCT
                     VFSNFPVIKNKNISHVHTMDFSPRSGYFALGNEKGKALMYRLHHYSDF"
     exon            382..494
                     /gene="UTP18"
                     /gene_synonym="CGI-48; WDR50"
                     /inference="alignment:Splign:2.1.0"
     exon            495..593
                     /gene="UTP18"
                     /gene_synonym="CGI-48; WDR50"
                     /inference="alignment:Splign:2.1.0"
     exon            594..661
                     /gene="UTP18"
                     /gene_synonym="CGI-48; WDR50"
                     /inference="alignment:Splign:2.1.0"
     exon            662..750
                     /gene="UTP18"
                     /gene_synonym="CGI-48; WDR50"
                     /inference="alignment:Splign:2.1.0"
     exon            751..876
                     /gene="UTP18"
                     /gene_synonym="CGI-48; WDR50"
                     /inference="alignment:Splign:2.1.0"
     exon            877..1051
                     /gene="UTP18"
                     /gene_synonym="CGI-48; WDR50"
                     /inference="alignment:Splign:2.1.0"
     exon            1052..1152
                     /gene="UTP18"
                     /gene_synonym="CGI-48; WDR50"
                     /inference="alignment:Splign:2.1.0"
     exon            1153..1243
                     /gene="UTP18"
                     /gene_synonym="CGI-48; WDR50"
                     /inference="alignment:Splign:2.1.0"
     exon            1244..1367
                     /gene="UTP18"
                     /gene_synonym="CGI-48; WDR50"
                     /inference="alignment:Splign:2.1.0"
     exon            1368..1542
                     /gene="UTP18"
                     /gene_synonym="CGI-48; WDR50"
                     /inference="alignment:Splign:2.1.0"
     exon            1543..1685
                     /gene="UTP18"
                     /gene_synonym="CGI-48; WDR50"
                     /inference="alignment:Splign:2.1.0"
     exon            1686..1724
                     /gene="UTP18"
                     /gene_synonym="CGI-48; WDR50"
                     /inference="alignment:Splign:2.1.0"
     exon            1725..1876
                     /gene="UTP18"
                     /gene_synonym="CGI-48; WDR50"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1847..1852
                     /regulatory_class="polyA_signal_sequence"
                     /gene="UTP18"
                     /gene_synonym="CGI-48; WDR50"
                     /note="hexamer: AATAAA"
     polyA_site      1876
                     /gene="UTP18"
                     /gene_synonym="CGI-48; WDR50"
                     /note="major polyA site"
ORIGIN      
        1 gttccacgtg agcgcctgcg tttctcctca aacctaacga tgccgccgga gcggaggaga
       61 cgaatgaaac tggaccggag aaccggagcg aagccgaagc ggaagcccgg aatgaggccg
      121 gactggaaag ccggagcggg gccaggcggg cctccccaaa agcctgcccc ttcatcccag
      181 cggaaaccgc cggcccggcc gagcgcggcg gccgctgcga ttgcagtcgc ggcggcggag
      241 gaagagagac ggctccggca gcggaaccgc ctgaggctgg aggaggacaa accggccgtg
      301 gagcggtgct tggaggagct ggtcttcggc gacgtcgaga acgacgagga cgcgttgctg
      361 cggcgtctgc gaggcccgag ggttcaagaa catgaagact cgggtgactc agaagtggag
      421 aatgaagcaa aaggtaattt tccacctcaa aagaagccag tttgggtgga tgaagaagat
      481 gaagatgagg aaatggttga catgatgaac aatcggtttc ggaaggatat gatgaaaaat
      541 gctagtgaaa gtaaactttc gaaagacaac cttaaaaaga gacttaaaga agaattccaa
      601 catgccatgg gaggagtacc tgcctgggca gagactacta agcggaaaac atcttcagat
      661 gatgaaagtg aagaggatga agatgatttg ttgcaaagga ctgggaattt catatccaca
      721 tcaacttctc ttccaagagg aatcttgaag atgaagaact gccagcatgc gaatgctgaa
      781 cgtcctactg ttgctcggat ctcatctgtg cagttccatc ccggtgcaca gattgtgatg
      841 gttgctggat tagataatgc tgtatcacta tttcaggttg atgggaaaac aaatcctaaa
      901 attcagagca tctatttgga aaggtttcca atctttaagg cttgttttag tgctaatggg
      961 gaagaagttt tagccacgag tacccacagc aaggttcttt atgtctatga catgctggct
     1021 ggaaagttaa ttcctgtgca tcaagtgaga ggtttgaaag agaagatagt gaggagcttt
     1081 gaagtctccc cagatgggtc cttcttgctc ataaatggca ttgctggata tttgcatttg
     1141 ctagcaatga agaccaaaga actgattgga agcatgaaaa ttaatggaag ggttgcagca
     1201 tccacattct cttcagatag taagaaagta tacgcctctt cgggggatgg agaagtttat
     1261 gtttgggatg tgaactcaag gaagtgcctt aacagatttg ttgatgaagg cagtttatat
     1321 ggattaagca ttgccacatc taggaatgga cagtatgttg cttgtggttc taattgtgga
     1381 gtggtaaata tatacaatca agattcttgt ctccaagaaa caaacccaaa gccaataaaa
     1441 gctataatga acttggttac aggtgttact tctctgacct tcaatcctac tacagaaatc
     1501 ttggcaattg cttcagaaaa aatgaaagaa gcagtcagat tggttcatct tccttcctgt
     1561 acagtatttt caaacttccc agtcattaaa aataagaata tttctcatgt tcataccatg
     1621 gatttttctc cgagaagtgg atactttgcc ttggggaatg aaaagggcaa ggccctgatg
     1681 tataggttgc accattactc agacttctaa agagactatt tgaagtccag ttgagtcaca
     1741 agagaagcct gtcttgatat atcatctcag aaactttcct gaatatgtga taatatatgg
     1801 aaaatgattt atagatccag ctgtgcttaa gagccagtaa tgtcttaata aacatgtggc
     1861 agcttttgtt tgaaaa
//
