LOCUS       NM_032175               5096 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens UTP15 small subunit processome component (UTP15),
            transcript variant 1, mRNA.
ACCESSION   NM_032175
VERSION     NM_032175.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5096)
  AUTHORS   Singh,S., Vanden Broeck,A., Miller,L., Chaker-Margot,M. and
            Klinge,S.
  TITLE     Nucleolar maturation of the human small subunit processome
  JOURNAL   Science 373 (6560), eabj5338 (2021)
   PUBMED   34516797
REFERENCE   2  (bases 1 to 5096)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 5096)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Paulo,J.A., Cannon,J.R., Ting,L.,
            Baltier,K., Colby,G., Gebreab,F., Gygi,M.P., Parzen,H., Szpyt,J.,
            Tam,S., Zarraga,G., Pontano-Vaites,L., Swarup,S., White,A.E.,
            Schweppe,D.K., Rad,R., Erickson,B.K., Obar,R.A., Guruharsha,K.G.,
            Li,K., Artavanis-Tsakonas,S., Gygi,S.P. and Harper,J.W.
  TITLE     Architecture of the human interactome defines protein communities
            and disease networks
  JOURNAL   Nature 545 (7655), 505-509 (2017)
   PUBMED   28514442
REFERENCE   4  (bases 1 to 5096)
  AUTHORS   Wada,K., Sato,M., Araki,N., Kumeta,M., Hirai,Y., Takeyasu,K.,
            Furukawa,K. and Horigome,T.
  TITLE     Dynamics of WD-repeat containing proteins in SSU processome
            components
  JOURNAL   Biochem Cell Biol 92 (3), 191-199 (2014)
   PUBMED   24754225
REFERENCE   5  (bases 1 to 5096)
  AUTHORS   Sato,M., Araki,N., Kumeta,M., Takeyasu,K., Taguchi,Y., Asai,T.,
            Furukawa,K. and Horigome,T.
  TITLE     Interaction, mobility, and phosphorylation of human orthologues of
            WD repeat-containing components of the yeast SSU processome t-UTP
            sub-complex
  JOURNAL   Biochem Cell Biol 91 (6), 466-475 (2013)
   PUBMED   24219289
REFERENCE   6  (bases 1 to 5096)
  AUTHORS   Prieto,J.L. and McStay,B.
  TITLE     Recruitment of factors linking transcription and processing of
            pre-rRNA to NOR chromatin is UBF-dependent and occurs independent
            of transcription in human cells
  JOURNAL   Genes Dev 21 (16), 2041-2054 (2007)
   PUBMED   17699751
REFERENCE   7  (bases 1 to 5096)
  AUTHORS   Tsuritani,K., Irie,T., Yamashita,R., Sakakibara,Y., Wakaguri,H.,
            Kanai,A., Mizushima-Sugano,J., Sugano,S., Nakai,K. and Suzuki,Y.
  TITLE     Distinct class of putative 'non-conserved' promoters in humans:
            comparative studies of alternative promoters of human and mouse
            genes
  JOURNAL   Genome Res 17 (7), 1005-1014 (2007)
   PUBMED   17567985
REFERENCE   8  (bases 1 to 5096)
  AUTHORS   Van Hooser,A.A., Yuh,P. and Heald,R.
  TITLE     The perichromosomal layer
  JOURNAL   Chromosoma 114 (6), 377-388 (2005)
   PUBMED   16136320
  REMARK    Review article
REFERENCE   9  (bases 1 to 5096)
  AUTHORS   Scherl,A., Coute,Y., Deon,C., Calle,A., Kindbeiter,K.,
            Sanchez,J.C., Greco,A., Hochstrasser,D. and Diaz,J.J.
  TITLE     Functional proteomic analysis of human nucleolus
  JOURNAL   Mol Biol Cell 13 (11), 4100-4109 (2002)
   PUBMED   12429849
REFERENCE   10 (bases 1 to 5096)
  AUTHORS   Simpson,J.C., Wellenreuther,R., Poustka,A., Pepperkok,R. and
            Wiemann,S.
  TITLE     Systematic subcellular localization of novel proteins identified by
            large-scale cDNA sequencing
  JOURNAL   EMBO Rep 1 (3), 287-292 (2000)
   PUBMED   11256614
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BP872156.1, AL831972.1, BC150197.1, AL520195.3, AK022849.1 and
            AC010279.5.
            
            On Nov 22, 2018 this sequence version replaced NM_032175.3.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660809.182885.1,
                                           SRR1660809.260870.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000296792.9/ ENSP00000296792.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-12                BP872156.1         5-16
            13-1464             AL831972.1         1-1452
            1465-2232           BC150197.1         3101-3868
            2233-2394           AL520195.3         570-731
            2395-3383           AK022849.1         1461-2449
            3384-5096           AC010279.5         118823-120535
FEATURES             Location/Qualifiers
     source          1..5096
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q13.2"
     gene            1..5096
                     /gene="UTP15"
                     /gene_synonym="NET21"
                     /note="UTP15 small subunit processome component"
                     /db_xref="GeneID:84135"
                     /db_xref="HGNC:HGNC:25758"
                     /db_xref="MIM:616194"
     exon            1..170
                     /gene="UTP15"
                     /gene_synonym="NET21"
                     /inference="alignment:Splign:2.1.0"
     exon            171..343
                     /gene="UTP15"
                     /gene_synonym="NET21"
                     /inference="alignment:Splign:2.1.0"
     CDS             254..1810
                     /gene="UTP15"
                     /gene_synonym="NET21"
                     /note="isoform 1 is encoded by transcript variant 1;
                     Src-associated protein SAW; U3 small nucleolar
                     RNA-associated protein 15 homolog; UTP15, U3 small
                     nucleolar ribonucleoprotein, homolog; UTP15 SSU processome
                     component"
                     /codon_start=1
                     /product="U3 small nucleolar RNA-associated protein 15
                     homolog isoform 1"
                     /protein_id="NP_115551.2"
                     /db_xref="CCDS:CCDS34186.1"
                     /db_xref="GeneID:84135"
                     /db_xref="HGNC:HGNC:25758"
                     /db_xref="MIM:616194"
                     /translation="MAGYKPVAIQTYPILGEKITQDTLYWNNYKTPVQIKEFGAVSKV
                     DFSPQPPYNYAVTASSRIHIYGRYSQEPIKTFSRFKDTAYCATFRQDGRLLVAGSEDG
                     GVQLFDISGRAPLRQFEGHTKAVHTVDFTADKYHVVSGADDYTVKLWDIPNSKEILTF
                     KEHSDYVRCGCASKLNPDLFITGSYDHTVKMFDARTSESVLSVEHGQPVESVLLFPSG
                     GLLVSAGGRYVKVWDMLKGGQLLVSLKNHHKTVTCLCLSSSGQRLLSGSLDRKVKVYS
                     TTSYKVVHSFDYAASILSLALAHEDETIVVGMTNGILSVKHRKSEAKKESLPRRRRPA
                     YRTFIKGKNYMKQRDDILINRPAKKHLELYDRDLKHFRISKALDRVLDPTCTIKTPEI
                     TVSIIKELNRRGVLANALAGRDEKEISHVLNFLIRNLSQPRFAPVLINAAEIIIDIYL
                     PVIGQSPVVDKKFLLLQGLVEKEIDYQRELLETLGMMDMLFATMRRKEGTSVLEHTSD
                     GFPENKKIES"
     exon            344..436
                     /gene="UTP15"
                     /gene_synonym="NET21"
                     /inference="alignment:Splign:2.1.0"
     exon            437..621
                     /gene="UTP15"
                     /gene_synonym="NET21"
                     /inference="alignment:Splign:2.1.0"
     exon            622..800
                     /gene="UTP15"
                     /gene_synonym="NET21"
                     /inference="alignment:Splign:2.1.0"
     exon            801..926
                     /gene="UTP15"
                     /gene_synonym="NET21"
                     /inference="alignment:Splign:2.1.0"
     exon            927..1062
                     /gene="UTP15"
                     /gene_synonym="NET21"
                     /inference="alignment:Splign:2.1.0"
     exon            1063..1147
                     /gene="UTP15"
                     /gene_synonym="NET21"
                     /inference="alignment:Splign:2.1.0"
     exon            1148..1297
                     /gene="UTP15"
                     /gene_synonym="NET21"
                     /inference="alignment:Splign:2.1.0"
     exon            1298..1399
                     /gene="UTP15"
                     /gene_synonym="NET21"
                     /inference="alignment:Splign:2.1.0"
     exon            1400..1533
                     /gene="UTP15"
                     /gene_synonym="NET21"
                     /inference="alignment:Splign:2.1.0"
     exon            1534..1592
                     /gene="UTP15"
                     /gene_synonym="NET21"
                     /inference="alignment:Splign:2.1.0"
     exon            1593..5096
                     /gene="UTP15"
                     /gene_synonym="NET21"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2212..2217
                     /regulatory_class="polyA_signal_sequence"
                     /gene="UTP15"
                     /gene_synonym="NET21"
                     /note="hexamer: AACAAA"
     polyA_site      2238
                     /gene="UTP15"
                     /gene_synonym="NET21"
                     /note="major polyA site"
     regulatory      3660..3665
                     /regulatory_class="polyA_signal_sequence"
                     /gene="UTP15"
                     /gene_synonym="NET21"
                     /note="hexamer: AATAAA"
     polyA_site      3680
                     /gene="UTP15"
                     /gene_synonym="NET21"
     regulatory      4781..4786
                     /regulatory_class="polyA_signal_sequence"
                     /gene="UTP15"
                     /gene_synonym="NET21"
                     /note="hexamer: AACAAA"
     polyA_site      4786
                     /gene="UTP15"
                     /gene_synonym="NET21"
     polyA_site      4805
                     /gene="UTP15"
                     /gene_synonym="NET21"
     regulatory      4848..4853
                     /regulatory_class="polyA_signal_sequence"
                     /gene="UTP15"
                     /gene_synonym="NET21"
                     /note="hexamer: ATTAAA"
     polyA_site      4875
                     /gene="UTP15"
                     /gene_synonym="NET21"
     regulatory      5063..5068
                     /regulatory_class="polyA_signal_sequence"
                     /gene="UTP15"
                     /gene_synonym="NET21"
                     /note="hexamer: AATAAA"
     polyA_site      5096
                     /gene="UTP15"
                     /gene_synonym="NET21"
ORIGIN      
        1 acgtcatctt cgcgcgacgt tcggttcgct gtgtgtgtcg ccggctcctt gagggtccat
       61 gtgattttta cgccagtgct gctgaactgt gcagggtagg gagctggcac agtccgatta
      121 attgtccttg ggtcgaggtg tctcgtcgga ccctttgggg ctcagtggag aattaaggca
      181 gagtcactgt aattatttct aataccaatt ccaaaatagt gactcttgga caatagtgca
      241 attatatgga attatggctg gttataagcc tgtagctatt cagacatatc ctatacttgg
      301 tgaaaaaatc acccaagata cactgtactg gaacaactat aagacccctg ttcagattaa
      361 ggaatttggt gcagtttcaa aagtagactt ttctcctcag cctccatata attatgctgt
      421 cacagcttcc tcaagaattc acatttatgg ccgatactcc caagaaccta taaaaacctt
      481 ttctcgattt aaagacacag catactgtgc tacttttcga caagatggta gattgcttgt
      541 ggctggcagt gaagatggtg gagttcaact ttttgatata agtgggaggg ctcccctcag
      601 gcagtttgaa ggccatacaa aagcagttca tacagtagat tttacagctg acaaatatca
      661 cgtggtctct ggggctgatg attatacagt taaattatgg gatattccaa actccaaaga
      721 aattttgaca tttaaagaac actctgatta tgtgaggtgt ggatgtgcta gcaaacttaa
      781 tccggatctc tttataacag gatcatatga tcatactgtg aagatgtttg atgcacgaac
      841 gagtgagagt gttctctccg ttgagcatgg gcagccagtg gagagtgtcc tacttttccc
      901 ctctggaggt cttctggtgt cagcaggagg tcgttatgtt aaagtctggg acatgttaaa
      961 aggaggacaa ttgctagtat ctttgaaaaa tcatcacaaa accgtgacat gtttatgtct
     1021 aagcagctct ggacagaggt tactctctgg ctcactggat aggaaggtga aagtatacag
     1081 cacaacttcc tacaaagtag tccacagttt tgattatgca gcttcaattt tgagtcttgc
     1141 ccttgcacat gaagatgaga caatagttgt aggaatgacc aatggaatac tgagtgttaa
     1201 acatcggaaa tctgaagcaa agaaggaatc acttcccaga agaagaaggc ctgcatatcg
     1261 aacctttatt aaaggaaaaa attacatgaa gcaacgggat gacattttga ttaacaggcc
     1321 agcaaagaag cacctagaat tgtatgacag ggatctgaaa cattttcgga tctctaaggc
     1381 actcgataga gttcttgatc ccacttgtac aataaagaca cccgagatta cggtgtccat
     1441 cataaaggag ttaaatcgaa gaggagtcct tgcaaatgcg cttgcaggtc gggatgagaa
     1501 ggaaatcagt catgttctta attttttgat aaggaatctt tctcagccaa gatttgcccc
     1561 tgttttaatc aatgctgctg aaataattat tgatatatat ctgcctgtaa ttggtcagtc
     1621 ccctgtagtt gataaaaagt ttttactact tcaaggactt gtagaaaaag agattgatta
     1681 ccaaagagaa ttgttagaaa ccttggggat gatggatatg ctttttgcca ccatgagaag
     1741 gaaggaaggc acttctgtgt tggaacacac atctgatgga tttccagaga ataagaagat
     1801 agaatcatag tgtctgctaa ataagacata taagaactct gaagttggaa tagatttgac
     1861 tgtattaaat gttggcgaga gactctcttt gatacattaa aaaaactgtt tgcagaagca
     1921 gttctgtgga agagactgga ataattatgg ccggaaaaca agtacccgtt ttaagtaaga
     1981 catggttttc catgtaatat tttgaattat agcatcttca cctagaagat ctcaattgtc
     2041 ttagtcacag agtaggttta tctgggatgg atattaattt taatacagga gtgttctgta
     2101 tcaacatttg ggttggtatt cagatgggaa ttcaaatatg aatcctctct ggagagggtc
     2161 caactgggaa tcctgctaaa ggagcaaagc cttgtattac ctctggaaga caacaaaaac
     2221 aattggcaac aacaaaaagc ctctttcttg actttaatca gtgcctttgg gatttctagg
     2281 cccttgctta gcttgcttcc tgtctccttg atatctacac ttgtcttaga tcacatgccc
     2341 tgcttcagct ggtaatggga ctgcatcggt tccaagtgtg gcaagtaagt tttcggctct
     2401 gaagaactga cactagctag atttgtattc agagtgtgag agcaagctct acagatagac
     2461 cttattggac tacttttttt tttttcttca tgcagccttt ctaccaagtt ttcaccttgt
     2521 ttcaggtcag aggaatgata gaatttgtca tttttcttac aacagccttt cagactattc
     2581 ttcatatgtt tcaagctaat cttgtagcta agctacctaa tcctctgaaa actgttttct
     2641 ctgatttgta tttagattcc tccccccatt attcacaatc atattgtatt tcggaacccc
     2701 aatgcagagc agtttgcttt gaaaaatagt tgtttttaaa agtttaatgt aaataattat
     2761 tttttagaag tttttttttt ttttttaaag acagggtctc gctttatcgc ccaggctgga
     2821 gtacagtgat gcaatctcag tccactgcaa cctctgccct cccgggttta agcagttctc
     2881 ctgcctcagc ctcctgagta gctgggatta caggtgtgcc ccaccacgcc tggctaattt
     2941 ttgtagtttt agtagagacg gggtttcacc ttaccgggct ggtctaaaac tcctgacctc
     3001 aagtgatcta cctgcctctg cctcccgaag tgcttggatt acaggtgtga gccactgtgt
     3061 ccagcctgta actattattt ttttataaag agagattctt attttcttgg ctttttgatg
     3121 tatctgttcc tgatagataa tcattggcta gtaactccta gtacactggt ttcacagttg
     3181 ctacctctcc tgcttttctc taattattac gccaactcaa gtagttaaaa atcagtaaga
     3241 aaaatgtctt gagctagaag aacccataga ggaagatttt gtaatgcgaa tctcctctca
     3301 taattttagt tctgtaaatt cagggttttt ttttgttttt ttgttttttt taagccgaaa
     3361 aaatgcttaa tatgttccag taagggtatt aagtaaaaat taaataaacg tattaagttt
     3421 aacatattaa attaatttaa catttagact aacattaaca tttaaattaa tatgttaagt
     3481 gaatatactt aatatattct agtacaggta tgcttggaaa tagggcgttt ccttttcatg
     3541 aattgatttc gtacagcaca gtggcttata aggaaccagc agtgtttttc cctgagtaat
     3601 tatgaactta gtcaagatca gaagctgggt tttggggttg agaagagttc atttatttaa
     3661 ataaagtttc tatttaaaaa cctttttaaa aagttaacat cataaatatt ctgataattt
     3721 gcatagtagt aaaaattaga agttgaaatt ctacctaaag ctgtagttgc cgtcaattgt
     3781 gtaacatgtg acaaaggttt tcccatatgt catttcattt gattctcacc acaaccatcc
     3841 aaggttgatg ttattctcat ttaacattga gttaacgaaa gtagttgatt cactctcgaa
     3901 gtccctgagt gtgagctctt catcctagca ctgtgaagtg gtttgcctgc tggggcctaa
     3961 actcctcatt ccctttaaca aagcttcact gagtgctgca gttctcaaaa tatgtaacag
     4021 ttaacacatt tttcaaacag gttaggaagc aattcccata gccatcaata cttaaattca
     4081 ggagtacttt tttgtttgtt tgttttgttt tgtttttaga gacaaggtct ctttctgttg
     4141 tccaggctgg agtgtagtgg tgtgatcata gctcactgca gcttctgtct cctaggctga
     4201 agctatcctc ccacctcagc ctcctgagaa gctggggcta cagggatgag ccaccatgcc
     4261 cagctaattt tttattttga ttttttgaga taagaggtct caccatgttg cccaggcctg
     4321 aggcaatctc ctggtttcaa gcaatcttcc cacctcagcc tccttaatga ctgggattaa
     4381 aggcatgagc cactgcgccc agcaggaatg gttattatat tcattgagat aaactgtagt
     4441 atttgctgtt tgaagtattt aaacataatt ggcatattac aatatgtgac actggcctta
     4501 agattctaat ttaaaatgct taacagactt ttagacttat gagtttcagt tgaaaggtat
     4561 tttaaaatgt tactaagtct gcaaaagtac tgaaatgttt cagagaactt ggaaagtcac
     4621 cgtatgttta atttattatg tttatgagat ttaagcactt gggaaggttt atgctaatgg
     4681 ggtcaagcat ttgcaatgct gcttaaaaga atcatttttt taaatgtata aatgctatta
     4741 agttgtttaa aggaatttga attgtaaatg ggattgttaa aacaaattta gtctgttcaa
     4801 ctcaatgagg gcatttcatt ttctaggaac aaaataccct cttagacatt aaaaagccgc
     4861 atgcctgttc cctcagctat agttaactgg accatggtgg tacaactgac tcaacccttc
     4921 tctaagcagg gatttgtaat tgggatttat aatgaaattc ctgatctggg aaaatgggag
     4981 gctgggaatg ctatgtctag gtcatcagcg gagaaagttg gtttgtagag aatgaacaag
     5041 aatgaaacct aagtgcaaag aaaataaaga ttatcctgct ttaatagttc agacta
//
