LOCUS       NM_021645               5529 bp    mRNA    linear   PRI 08-JUN-2024
DEFINITION  Homo sapiens UTP14C small subunit processome component (UTP14C),
            mRNA.
ACCESSION   NM_021645 XM_375024
VERSION     NM_021645.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5529)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 5529)
  AUTHORS   Yachie,N., Petsalaki,E., Mellor,J.C., Weile,J., Jacob,Y., Verby,M.,
            Ozturk,S.B., Li,S., Cote,A.G., Mosca,R., Knapp,J.J., Ko,M., Yu,A.,
            Gebbia,M., Sahni,N., Yi,S., Tyagi,T., Sheykhkarimli,D., Roth,J.F.,
            Wong,C., Musa,L., Snider,J., Liu,Y.C., Yu,H., Braun,P.,
            Stagljar,I., Hao,T., Calderwood,M.A., Pelletier,L., Aloy,P.,
            Hill,D.E., Vidal,M. and Roth,F.P.
  TITLE     Pooled-matrix protein interaction screens using Barcode Fusion
            Genetics
  JOURNAL   Mol Syst Biol 12 (4), 863 (2016)
   PUBMED   27107012
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5529)
  AUTHORS   Rohozinski,J., Edwards,C.L. and Anderson,M.L.
  TITLE     Does expression of the retrogene UTP14c in the ovary pre-dispose
            women to ovarian cancer?
  JOURNAL   Med Hypotheses 78 (4), 446-449 (2012)
   PUBMED   22285623
  REMARK    GeneRIF: We hypothesize that women, whose ovaries express UTP14c,
            are predisposed to ovarian cancer due to the disruption of
            protective signals that normally trigger TP53-mediated apoptosis
            and the dysregulation of genes that promote oncogenesis
REFERENCE   4  (bases 1 to 5529)
  AUTHORS   Rohozinski,J., Lamb,D.J. and Bishop,C.E.
  TITLE     UTP14c is a recently acquired retrogene associated with
            spermatogenesis and fertility in man
  JOURNAL   Biol Reprod 74 (4), 644-651 (2006)
   PUBMED   16354793
  REMARK    GeneRIF: may be functionally equivalent to mouse Utp14b and
            required for normal male fertility in humans
REFERENCE   5  (bases 1 to 5529)
  AUTHORS   Rohozinski,J. and Bishop,C.E.
  TITLE     The mouse juvenile spermatogonial depletion (jsd) phenotype is due
            to a mutation in the X-derived retrogene, mUtp14b
  JOURNAL   Proc Natl Acad Sci U S A 101 (32), 11695-11700 (2004)
   PUBMED   15289605
REFERENCE   6  (bases 1 to 5529)
  AUTHORS   Dunham,A., Matthews,L.H., Burton,J., Ashurst,J.L., Howe,K.L.,
            Ashcroft,K.J., Beare,D.M., Burford,D.C., Hunt,S.E.,
            Griffiths-Jones,S., Jones,M.C., Keenan,S.J., Oliver,K., Scott,C.E.,
            Ainscough,R., Almeida,J.P., Ambrose,K.D., Andrews,D.T.,
            Ashwell,R.I., Babbage,A.K., Bagguley,C.L., Bailey,J., Bannerjee,R.,
            Barlow,K.F., Bates,K., Beasley,H., Bird,C.P., Bray-Allen,S.,
            Brown,A.J., Brown,J.Y., Burrill,W., Carder,C., Carter,N.P.,
            Chapman,J.C., Clamp,M.E., Clark,S.Y., Clarke,G., Clee,C.M.,
            Clegg,S.C., Cobley,V., Collins,J.E., Corby,N., Coville,G.J.,
            Deloukas,P., Dhami,P., Dunham,I., Dunn,M., Earthrowl,M.E.,
            Ellington,A.G., Faulkner,L., Frankish,A.G., Frankland,J.,
            French,L., Garner,P., Garnett,J., Gilbert,J.G., Gilson,C.J.,
            Ghori,J., Grafham,D.V., Gribble,S.M., Griffiths,C., Hall,R.E.,
            Hammond,S., Harley,J.L., Hart,E.A., Heath,P.D., Howden,P.J.,
            Huckle,E.J., Hunt,P.J., Hunt,A.R., Johnson,C., Johnson,D., Kay,M.,
            Kimberley,A.M., King,A., Laird,G.K., Langford,C.J., Lawlor,S.,
            Leongamornlert,D.A., Lloyd,D.M., Lloyd,C., Loveland,J.E.,
            Lovell,J., Martin,S., Mashreghi-Mohammadi,M., McLaren,S.J.,
            McMurray,A., Milne,S., Moore,M.J., Nickerson,T., Palmer,S.A.,
            Pearce,A.V., Peck,A.I., Pelan,S., Phillimore,B., Porter,K.M.,
            Rice,C.M., Searle,S., Sehra,H.K., Shownkeen,R., Skuce,C.D.,
            Smith,M., Steward,C.A., Sycamore,N., Tester,J., Thomas,D.W.,
            Tracey,A., Tromans,A., Tubby,B., Wall,M., Wallis,J.M., West,A.P.,
            Whitehead,S.L., Willey,D.L., Wilming,L., Wray,P.W., Wright,M.W.,
            Young,L., Coulson,A., Durbin,R., Hubbard,T., Sulston,J.E., Beck,S.,
            Bentley,D.R., Rogers,J. and Ross,M.T.
  TITLE     The DNA sequence and analysis of human chromosome 13
  JOURNAL   Nature 428 (6982), 522-528 (2004)
   PUBMED   15057823
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            D87455.1, BC089407.1, N71815.1 and AI076921.1.
            
            On May 17, 2019 this sequence version replaced NM_021645.5.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803612.196961.1,
                                           SRR1803614.215655.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000521776.2/ ENSP00000428619.1
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3956              D87455.1           1-3956
            3957-4113           BC089407.1         3367-3523
            4114-4928           D87455.1           4205-5019
            4929-5081           N71815.1           75-227
            5082-5494           D87455.1           5173-5585
            5495-5529           AI076921.1         9-43                c
FEATURES             Location/Qualifiers
     source          1..5529
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="13"
                     /map="13q14.3"
     gene            1..5529
                     /gene="UTP14C"
                     /gene_synonym="2700066J21Rik; KIAA0266; UTP14B"
                     /note="UTP14C small subunit processome component"
                     /db_xref="GeneID:9724"
                     /db_xref="HGNC:HGNC:20321"
                     /db_xref="MIM:608969"
     exon            1..247
                     /gene="UTP14C"
                     /gene_synonym="2700066J21Rik; KIAA0266; UTP14B"
                     /inference="alignment:Splign:2.1.0"
     exon            248..5529
                     /gene="UTP14C"
                     /gene_synonym="2700066J21Rik; KIAA0266; UTP14B"
                     /inference="alignment:Splign:2.1.0"
     CDS             734..3034
                     /gene="UTP14C"
                     /gene_synonym="2700066J21Rik; KIAA0266; UTP14B"
                     /note="UTP14, U3 small nucleolar ribonucleoprotein,
                     homolog C; UTP14, small subunit processome component
                     homolog C"
                     /codon_start=1
                     /product="U3 small nucleolar RNA-associated protein 14
                     homolog C"
                     /protein_id="NP_067677.4"
                     /db_xref="CCDS:CCDS31978.1"
                     /db_xref="GeneID:9724"
                     /db_xref="HGNC:HGNC:20321"
                     /db_xref="MIM:608969"
                     /translation="MNVNQVAENLALSHQEELVDLPKNYPLSENEDEGDSDGERKHQK
                     LLEAIISLDGKNRRKLAERSEASLKVSEFSVSSEGSGEKLGLADLLEPVKTSSSLATV
                     KKQLNRVKSKKVVELPLNKEKIEQIHREVAFSKTSQVLSKWDPIILKNQQAEQLVFPL
                     GKEQPAIAPIEHALSGWKARTPLEQEIFNLLHKNKQPVTDPLLTPMEKASLQAMSLEE
                     AKMHRAELQRARALQSYYEAKARKEKKIKSKKYHKVVKKGKAKKALKEFEQLQKVNPT
                     VALEEMEKIENARMMERMSLKHQNSGKWAKSKAIMAKYDLEARQAMQEQLAKNKELTQ
                     KLQVASESEEEEGGTEVEELLVPHVANEVQMNVDGPNPWMFRSCTSDTKEAATQEDPE
                     QVPELAAHEVSASEAEERPVAEEEILLREFEERQSLRKRSELNQDAEPASSQETKDSS
                     SQEVLSELRALSQKLKEKHQSRKQKASSEGTVPQVQREEPAPEEAEPLLLQRSERVQT
                     LEELEELGKEDCFQNKELPRPVLEGQQSERTPNNRPDAPKEKKEKEQLINLQNFLTTQ
                     SPSVRSLAVPTIIEELEDEEERDQRQMIKEAFAGDDVIRDFLKEKREAVEASKPKDVD
                     LTLPGWGEWGGVGLKPSAKKRRQFLIKAPEGPPRKDKNLPNVIISEKRNIHAAAHQVQ
                     VLPYPFTHHRQFERTIQTPIGSTWNTQRAFQKLTTPKVVTKPGHIIKPIKAEDVGYQS
                     SSRSDLPVIQRNPKRITTRHNKEEKL"
     regulatory      5488..5493
                     /regulatory_class="polyA_signal_sequence"
                     /gene="UTP14C"
                     /gene_synonym="2700066J21Rik; KIAA0266; UTP14B"
                     /note="hexamer: AAGAAA"
     regulatory      5498..5503
                     /regulatory_class="polyA_signal_sequence"
                     /gene="UTP14C"
                     /gene_synonym="2700066J21Rik; KIAA0266; UTP14B"
                     /note="hexamer: AATAAA"
     polyA_site      5504
                     /gene="UTP14C"
                     /gene_synonym="2700066J21Rik; KIAA0266; UTP14B"
                     /note="major polyA site"
     polyA_site      5529
                     /gene="UTP14C"
                     /gene_synonym="2700066J21Rik; KIAA0266; UTP14B"
                     /note="major polyA site"
ORIGIN      
        1 gcctttgcta aattgctgaa taagaagatg gttgagtcac ctccttcgct taaacttgtc
       61 ctcattggag gttgtcgtaa caaagatgat gaacttaggg taaaccaact gagaaggctg
      121 tctgaggatt taggagttca agaatatgtg gaatttaaaa taaacattcc atttgatgaa
      181 ttaaagaatt atttgtctga agcaacaatt ggtctgcata ccatgtggaa cgagcatttt
      241 gggattggag ttgtggagtg tatggcagct ggcacaatta tccttgcaca caattcgggg
      301 ggcccaaagc ttgacattgt ggttcctcac gaaggagata taactggctt tctggctgag
      361 agtgaagaag actatgctga aactatcgct cacattcttt ccatgtctgc agaaaagaga
      421 ctccaaatca gaaaaagtgc tcgtgcatct gtaagcagat tctctgatca ggaatttgaa
      481 gtgacattcc tatcatctgt ggaaaagtta tttaagtaat gccatatctg taaaattaaa
      541 gatattttat ataaactggt taaacacctt catatgtaaa tatttttcta aattcaatct
      601 catttgtcaa atcattttac tttagaaaac agacaaaatt tccttttaga ataaaaggaa
      661 gtgttgaaaa gaaaatggat gactagcctt cggcttccat tcttggtata catgagagag
      721 gctggctgct gagatgaatg tgaaccaggt tgcagagaat ctggctttga gccaccagga
      781 agaactagtg gatttgccaa aaaactaccc cttgagtgaa aatgaagatg agggggacag
      841 tgatggagag agaaagcatc aaaagcttct ggaagcaatc atttcccttg atggaaagaa
      901 taggcggaaa ttggctgaga ggtctgaggc tagtctgaaa gtgtcagagt tcagtgtcag
      961 ttctgaagga tcaggagaaa agctgggcct tgcagatctg cttgagcccg ttaaaacttc
     1021 atcttctttg gccactgtaa aaaagcaact gaatagagtc aaatcaaaga aggtggtgga
     1081 gttacctctt aacaaagaaa aaattgaaca gatccacaga gaagtagcat tcagtaaaac
     1141 ctcacaggtc ctctccaaat gggaccctat catcctgaag aaccagcagg cagagcagct
     1201 ggtttttccc ctggggaagg agcagccagc cattgctccc attgaacatg cgctcagtgg
     1261 ctggaaggca agaactcccc tggagcagga aatttttaac ctcctccata agaacaagca
     1321 gccagtgaca gatcctttac tgactcccat ggaaaaggcc tctctccaag ccatgagcct
     1381 ggaagaggca aagatgcacc gagcagagct tcagagggct cgggctctgc agtcctacta
     1441 tgaggccaag gctcgaaaag agaagaaaat caaaagtaaa aagtatcaca aagtcgtgaa
     1501 gaaaggaaag gccaagaaag ccttaaaaga gtttgagcag ctacagaagg ttaatccaac
     1561 tgtggcactg gaagaaatgg aaaaaattga aaatgccaga atgatggaaa gaatgagcct
     1621 taagcaccaa aacagtggga aatgggccaa gtcaaaggca attatggcca aatatgacct
     1681 ggaggctcgc caagctatgc aggaacagtt ggccaagaac aaagaactga cacagaaact
     1741 ccaggtagcc tctgagagtg aggaagagga gggaggcaca gaagtggaag aactccttgt
     1801 ccctcatgta gcgaatgaag tgcagatgaa tgtggacgga ccgaatccct ggatgttcag
     1861 gagctgcacc agtgacacca aagaggctgc aacacaggag gaccctgagc aagtgccaga
     1921 gcttgcagct catgaggttt ctgcaagtga ggcagaagaa agaccagtgg cagaggaaga
     1981 aattttgttg agagaatttg aggaaaggca atcccttaga aaaagatctg agctcaacca
     2041 ggatgctgag ccagcaagca gtcaagaaac aaaagattct agcagccagg aggtgctgtc
     2101 cgaattgagg gcactatctc agaaattgaa ggaaaaacat cagtccagga agcaaaaagc
     2161 aagttcagag gggactgttc cccaggtcca gagagaggaa cctgccccag aagaagcgga
     2221 acccctattg ctacagaggt cagagagagt acaaactctg gaagagctag aagagctggg
     2281 aaaagaagat tgttttcaaa ataaggagct tcccagacct gtgttagaag gacagcagtc
     2341 agagaggacc ccaaataatc ggcctgatgc ccctaaggag aagaaagaga aggagcaact
     2401 gatcaaccta cagaacttcc tgaccacaca gtctccttcc gtgaggtctt tggcagttcc
     2461 cacaataata gaggagctgg aagatgaaga ggagagagac caaaggcaga tgataaagga
     2521 agcttttgct ggggatgatg tcatcagaga tttcttgaaa gagaagaggg aagctgtgga
     2581 ggcgagtaag ccaaaggacg tggacctgac actacctggc tggggcgagt ggggtggtgt
     2641 gggcctaaag cccagtgcca agaaaagacg ccagtttctc attaaagccc ctgagggtcc
     2701 tccaagaaaa gataagaatt tgccaaatgt gattatcagt gagaagcgca acatccacgc
     2761 agcagctcat caggtacaag tgcttccata tccatttacc caccatcggc aatttgaaag
     2821 gaccatccag acccctatag gatccacatg gaacacccag agggctttcc aaaagctgac
     2881 tactcccaag gtcgtcacca agccaggcca tatcattaag cccataaaag cagaggatgt
     2941 gggctaccag tcttcctcaa ggtcagacct gcctgtcata cagaggaatc caaaacgaat
     3001 caccacacgt cacaataaag aagaaaaact gtaggttgtg tagctggaga agtgacagtc
     3061 aggggccctg attccacttc ctttggtcca gttttactct gctacagggt ggattccaaa
     3121 actggctcag cacattgcat gtagttgagc cacatttttt aaaaaaagaa aatggatgac
     3181 cattaattga ctagcatttt agaattgatc agacattaga acacagaaaa attctagtac
     3241 atttaaattc taaacaatac agtggatgac ccttttgaat atacctaatg atttccttaa
     3301 aaaagaaatt ttaaacagac ttgtttaatc gtgttctcaa agcatacagt caagaggtgg
     3361 gactgactga tgctttatag gtgtgtgtag ggtggtagag gccaaggtgc tgccagcaat
     3421 cctttccata ctaggtactg gtgaaaattg tttttgttta tgctgtcagc acatttgtgt
     3481 gggtctctca ttgtccctta acagtgccgc atctcagcct ggaagtcagc tttaagtcat
     3541 tcaagagaac ctcaggctgt ttttctgaca gtgatgatat gatatacaga tacatccaca
     3601 gggtatctat taccagcata atgcattgta agatggcaag gtggcatttt gaaagagcgc
     3661 tgggcaagca gttagcacat ctgggcctac cttcagcttc ttcatttaca aacttctgac
     3721 cttttgacac taaagctgct cctttatctt tctgagtctc agattcttca tctgtaatct
     3781 ggagttgtta attccagtcc ttactacctt ttagagttgg aatgagatgg aaagtagatg
     3841 aaactacttt gaaaattacg acagttaagg gctgggtgcg gtgtctcaca cctgtaatcc
     3901 cagcactttg ggaggccgag atgggtggat catgaggtca gcagttgaga ccagcctgaa
     3961 caacatggtg aaaccctgtc tgtactaaaa atacaaaaaa attagctggg cctggtggca
     4021 ggcacctgta atcccagcta cttgggagac tgaggcagga gaattgcttg aaactggaag
     4081 gcagaggttg cagtgagcca agattgtgcc actgcactct agcctgggca ataagcaaaa
     4141 ctccatctca aaaaagaaaa aaaggaaaaa gaaaattatg agagttactt aaaggtaaca
     4201 tcacatacta aatgtcttct ataatcctat atttattaat gcattacaac tctgtagatt
     4261 gttagttact aggccagtag ctaggaattg gtataaattt aatgcacctt ctatcctgaa
     4321 taactagcat ggaaaagtga atatatgtgt gagcagatat ggctataaag acctatagct
     4381 tttgcacttt atgcatatat aatcaatcct ttctagttca gtgaattgac cccatccaca
     4441 ggctgattca tctttgtgtt aaggggcaaa tgaaacggta tattatttct ttgcagtctc
     4501 ctctcagtca ttcatcaatg tggccagctt atctactccc aattatgttg ttgatacatc
     4561 tccaagccat ctgtcatcag atcaaaaagc agcaaacaga gggtcagtca caggatgttc
     4621 tgacacacca ttgtaacttt ttgttagaga tgatcccatt tagaaaaaga ctggtagaaa
     4681 ttggagtgaa aggaacccta cagattagcc cagttctctc ttattttcag ctttacagac
     4741 aagaacaatt taaatctaaa gaatttagta gattccttca gtgtcacaaa gctgtttcat
     4801 gaaagaatca agattataac ctggatattc tgactcctgg cccagtgctt tttcttactt
     4861 tgtagctaca ctttgaagta agattcaaac tgttatccac tcaattgcct tattcctgag
     4921 gatgtagtga aggaagaaaa agttttctgg aattccgtaa attatatttt aagcttattt
     4981 cttcaaaatt attttcatat atcacagata tatcattgga agatataatt tgcatatatg
     5041 ttcattatca gtgttcctaa tttggtatta catgtattct atttttttct gaatgatagc
     5101 atgaaaagtg tcaaagtggt ttgtccgcta gcgtctgtct gcagaacttt caggatgact
     5161 attaattcct ctcagatgtc atttttgagt ggtccaagcc tgctgttttg aacccacagc
     5221 agtggagatt tgtattctta tttacagttg tgtactataa agtgtgtgtt acataggttt
     5281 tgtgtaataa ttatttgtaa atattattta gatttgtatt tagacatgat ttatatctaa
     5341 tatagataca aagtctgtgt ctaaatatta tttaaagaag tgatttttca ttctcttgga
     5401 ttctttccag tgtggtgcct tttatatgcc tcacatagtc tccttgttct cctactaata
     5461 ttcccaagct ccatatgcca attaaagaag aaacaaaaat aaaagtttgt cttgcttgtg
     5521 aaacattaa
//
