LOCUS       NM_006649               2507 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens UTP14A small subunit processome component (UTP14A),
            transcript variant 1, mRNA.
ACCESSION   NM_006649
VERSION     NM_006649.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2507)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   2  (bases 1 to 2507)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 2507)
  AUTHORS   Li,K.K., Mao,C.Y., Zhang,J.G., Ma,Q., Wang,Y.J., Liu,X.H., Bao,T.
            and Guo,W.
  TITLE     Overexpression of U three protein 14a (UTP14a) is associated with
            poor prognosis of esophageal squamous cell carcinoma
  JOURNAL   Thorac Cancer 10 (11), 2071-2080 (2019)
   PUBMED   31496055
  REMARK    GeneRIF: Results suggest that UTP14a expression is correlated with
            tumor proliferation and invasion; higher expression of UTP14a is a
            predictor of poor prognosis in patients with esophageal squamous
            cell carcinoma (ESCC). Additionally, knockdown of UTP14a inhibits
            cell proliferation and invasion in ESCC cell line, ECA109.
REFERENCE   4  (bases 1 to 2507)
  AUTHORS   Fragoza,R., Das,J., Wierbowski,S.D., Liang,J., Tran,T.N., Liang,S.,
            Beltran,J.F., Rivera-Erick,C.A., Ye,K., Wang,T.Y., Yao,L., Mort,M.,
            Stenson,P.D., Cooper,D.N., Wei,X., Keinan,A., Schimenti,J.C.,
            Clark,A.G. and Yu,H.
  TITLE     Extensive disruption of protein interactions by genetic variants
            across the allele frequency spectrum in human populations
  JOURNAL   Nat Commun 10 (1), 4141 (2019)
   PUBMED   31515488
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2507)
  AUTHORS   Ren,P., Sun,X., Zhang,C., Wang,L., Xing,B. and Du,X.
  TITLE     Human UTP14a promotes angiogenesis through upregulating PDGFA
            expression in colorectal cancer
  JOURNAL   Biochem Biophys Res Commun 512 (4), 871-876 (2019)
   PUBMED   30929921
  REMARK    GeneRIF: UTP14a promotes angiogenesis through upregulating
            transcription and secretion of PDGFA in colorectal cancer.
REFERENCE   6  (bases 1 to 2507)
  AUTHORS   Vinayagam,A., Stelzl,U., Foulle,R., Plassmann,S., Zenkner,M.,
            Timm,J., Assmus,H.E., Andrade-Navarro,M.A. and Wanker,E.E.
  TITLE     A directed protein interaction network for investigating
            intracellular signal transduction
  JOURNAL   Sci Signal 4 (189), rs8 (2011)
   PUBMED   21900206
REFERENCE   7  (bases 1 to 2507)
  AUTHORS   Hu,L., Wang,J., Liu,Y., Zhang,Y., Zhang,L., Kong,R., Zheng,Z.,
            Du,X. and Ke,Y.
  TITLE     A small ribosomal subunit (SSU) processome component, the human U3
            protein 14A (hUTP14A) binds p53 and promotes p53 degradation
  JOURNAL   J Biol Chem 286 (4), 3119-3128 (2011)
   PUBMED   21078665
  REMARK    GeneRIF: hUTP14a physically interacts with p53 and functionally
            promotes p53 turn-over
REFERENCE   8  (bases 1 to 2507)
  AUTHORS   Rohozinski,J., Lamb,D.J. and Bishop,C.E.
  TITLE     UTP14c is a recently acquired retrogene associated with
            spermatogenesis and fertility in man
  JOURNAL   Biol Reprod 74 (4), 644-651 (2006)
   PUBMED   16354793
REFERENCE   9  (bases 1 to 2507)
  AUTHORS   Rohozinski,J. and Bishop,C.E.
  TITLE     The mouse juvenile spermatogonial depletion (jsd) phenotype is due
            to a mutation in the X-derived retrogene, mUtp14b
  JOURNAL   Proc Natl Acad Sci U S A 101 (32), 11695-11700 (2004)
   PUBMED   15289605
REFERENCE   10 (bases 1 to 2507)
  AUTHORS   Scanlan,M.J., Chen,Y.T., Williamson,B., Gure,A.O., Stockert,E.,
            Gordan,J.D., Tureci,O., Sahin,U., Pfreundschuh,M. and Old,L.J.
  TITLE     Characterization of human colon cancer antigens recognized by
            autologous antibodies
  JOURNAL   Int J Cancer 76 (5), 652-658 (1998)
   PUBMED   9610721
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK291918.1 and BQ017502.1.
            
            On Nov 22, 2018 this sequence version replaced NM_006649.3.
            
            Summary: This gene encodes a member of the uridine triphosphate 14
            family. As an essential component of a large ribonucleoprotein
            complex bound to the U3 small nucleolar RNA, the encoded protein is
            involved in ribosome biogenesis and 18S rRNA synthesis. An
            autosomal retrotransposed copy of this X-linked gene exists on
            chromosome 13. Alternative splicing results in multiple transcript
            variants.[provided by RefSeq, Oct 2009].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC009649.1, SRR1803614.48295.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000394422.8/ ENSP00000377944.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2371              AK291918.1         11-2381
            2372-2507           BQ017502.1         28-163              c
FEATURES             Location/Qualifiers
     source          1..2507
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /map="Xq26.1"
     gene            1..2507
                     /gene="UTP14A"
                     /gene_synonym="dJ537K23.3; NYCO16; SDCCAG16; Utp14"
                     /note="UTP14A small subunit processome component"
                     /db_xref="GeneID:10813"
                     /db_xref="HGNC:HGNC:10665"
                     /db_xref="MIM:300508"
     exon            1..73
                     /gene="UTP14A"
                     /gene_synonym="dJ537K23.3; NYCO16; SDCCAG16; Utp14"
                     /inference="alignment:Splign:2.1.0"
     CDS             48..2363
                     /gene="UTP14A"
                     /gene_synonym="dJ537K23.3; NYCO16; SDCCAG16; Utp14"
                     /note="isoform 1 is encoded by transcript variant 1;
                     serologically defined colon cancer antigen 16; U3 small
                     nucleolar RNA-associated protein 14 homolog A; antigen
                     NY-CO-16; UTP14, U3 small nucleolar ribonucleoprotein,
                     homolog A; UTP14A small subunit (SSU) processome
                     component"
                     /codon_start=1
                     /product="U3 small nucleolar RNA-associated protein 14
                     homolog A isoform 1"
                     /protein_id="NP_006640.2"
                     /db_xref="CCDS:CCDS14615.1"
                     /db_xref="GeneID:10813"
                     /db_xref="HGNC:HGNC:10665"
                     /db_xref="MIM:300508"
                     /translation="MTANRLAESLLALSQQEELADLPKDYLLSESEDEGDNDGERKHQ
                     KLLEAISSLDGKNRRKLAERSEASLKVSEFNVSSEGSGEKLVLADLLEPVKTSSSLAT
                     VKKQLSRVKSKKTVELPLNKEEIERIHREVAFNKTAQVLSKWDPVVLKNRQAEQLVFP
                     LEKEEPAIAPIEHVLSGWKARTPLEQEIFNLLHKNKQPVTDPLLTPVEKASLRAMSLE
                     EAKMRRAELQRARALQSYYEAKARREKKIKSKKYHKVVKKGKAKKALKEFEQLRKVNP
                     AAALEELEKIEKARMMERMSLKHQNSGKWAKSKAIMAKYDLEARQAMQEQLSKNKELT
                     QKLQVASESEEEEGGTEDVEELLVPDVVNEVQMNADGPNPWMLRSCTSDTKEAATQED
                     PEQLPELEAHGVSESEGEERPVAEEEILLREFEERRSLRKRSELSQDAEPAGSQETKD
                     SGSQEVLSELRVLSQKLKENHQSRKQKASSEGTIPQVQREEPAPEEEEPLLLQRPERV
                     QTLEELEELGKEECFQNKELPRPVLEGQQSERTPNNRPDAPKEKKKKEQMIDLQNLLT
                     TQSPSVKSLAVPTIEELEDEEERNHRQMIKEAFAGDDVIRDFLKEKREAVEASKPKDV
                     DLTLPGWGEWGGVGLKPSAKKRRRFLIKAPEGPPRKDKNLPNVIINEKRNIHAAAHQV
                     RVLPYPFTHHWQFERTIQTPIGSTWNTQRAFQKLTTPKVVTKPGHIINPIKAEDVGYR
                     SSSRSDLSVIQRNPKRITTRHKKQLKKCSVD"
     exon            74..149
                     /gene="UTP14A"
                     /gene_synonym="dJ537K23.3; NYCO16; SDCCAG16; Utp14"
                     /inference="alignment:Splign:2.1.0"
     exon            150..220
                     /gene="UTP14A"
                     /gene_synonym="dJ537K23.3; NYCO16; SDCCAG16; Utp14"
                     /inference="alignment:Splign:2.1.0"
     exon            221..285
                     /gene="UTP14A"
                     /gene_synonym="dJ537K23.3; NYCO16; SDCCAG16; Utp14"
                     /inference="alignment:Splign:2.1.0"
     exon            286..428
                     /gene="UTP14A"
                     /gene_synonym="dJ537K23.3; NYCO16; SDCCAG16; Utp14"
                     /inference="alignment:Splign:2.1.0"
     exon            429..584
                     /gene="UTP14A"
                     /gene_synonym="dJ537K23.3; NYCO16; SDCCAG16; Utp14"
                     /inference="alignment:Splign:2.1.0"
     exon            585..704
                     /gene="UTP14A"
                     /gene_synonym="dJ537K23.3; NYCO16; SDCCAG16; Utp14"
                     /inference="alignment:Splign:2.1.0"
     exon            705..799
                     /gene="UTP14A"
                     /gene_synonym="dJ537K23.3; NYCO16; SDCCAG16; Utp14"
                     /inference="alignment:Splign:2.1.0"
     exon            800..923
                     /gene="UTP14A"
                     /gene_synonym="dJ537K23.3; NYCO16; SDCCAG16; Utp14"
                     /inference="alignment:Splign:2.1.0"
     exon            924..1001
                     /gene="UTP14A"
                     /gene_synonym="dJ537K23.3; NYCO16; SDCCAG16; Utp14"
                     /inference="alignment:Splign:2.1.0"
     exon            1002..1395
                     /gene="UTP14A"
                     /gene_synonym="dJ537K23.3; NYCO16; SDCCAG16; Utp14"
                     /inference="alignment:Splign:2.1.0"
     exon            1396..1796
                     /gene="UTP14A"
                     /gene_synonym="dJ537K23.3; NYCO16; SDCCAG16; Utp14"
                     /inference="alignment:Splign:2.1.0"
     exon            1797..1990
                     /gene="UTP14A"
                     /gene_synonym="dJ537K23.3; NYCO16; SDCCAG16; Utp14"
                     /inference="alignment:Splign:2.1.0"
     exon            1991..2090
                     /gene="UTP14A"
                     /gene_synonym="dJ537K23.3; NYCO16; SDCCAG16; Utp14"
                     /inference="alignment:Splign:2.1.0"
     exon            2091..2507
                     /gene="UTP14A"
                     /gene_synonym="dJ537K23.3; NYCO16; SDCCAG16; Utp14"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2486..2491
                     /regulatory_class="polyA_signal_sequence"
                     /gene="UTP14A"
                     /gene_synonym="dJ537K23.3; NYCO16; SDCCAG16; Utp14"
                     /note="hexamer: AATAAA"
     polyA_site      2507
                     /gene="UTP14A"
                     /gene_synonym="dJ537K23.3; NYCO16; SDCCAG16; Utp14"
                     /note="major polyA site"
ORIGIN      
        1 ccttcggctt ccgttcttgg tccatgtgag agaagctggc tgctgaaatg actgcgaacc
       61 ggcttgcaga gagccttctg gctttgagcc aacaggaaga actagcggat ttgccaaaag
      121 actacctctt gagtgagagt gaagatgagg gggacaatga tggagagaga aagcatcaaa
      181 agcttctgga agcaatcagt tcccttgatg gaaagaatag gcggaaattg gctgagaggt
      241 ctgaggctag tctgaaggtg tcagagttca atgtcagttc tgaaggatca ggagaaaagc
      301 tggtccttgc agatctgctt gagcctgtta aaacttcatc ttctttggcc actgtgaaaa
      361 agcaactgag tagagtcaaa tcaaagaaga cagtggagtt acctctgaac aaagaagaga
      421 ttgaacggat ccacagagaa gtagcattca ataaaaccgc acaagtcctc tccaaatggg
      481 accctgtcgt cctgaagaac cggcaggcag agcagctggt ttttcccctg gagaaagagg
      541 agccagccat tgctcccatt gaacatgtgc tcagtggctg gaaggcaaga actcccctgg
      601 agcaggaaat tttcaacctc ctccataaga acaagcagcc agtgacagac cctttactga
      661 cccctgtgga aaaggcctct ctccgagcca tgagcctaga agaggcaaag atgcgacgag
      721 cagagcttca gagggctcgg gctctgcagt cctactatga ggccaaggct cgaagagaga
      781 agaaaatcaa aagtaaaaag tatcacaaag tcgtgaagaa aggaaaggcc aagaaagccc
      841 taaaagagtt tgagcagctg cggaaggtta atccagctgc agcactagaa gaactggaaa
      901 aaattgaaaa ggccagaatg atggaaagaa tgagccttaa gcaccaaaac agtgggaaat
      961 gggccaagtc aaaggcaatt atggccaaat atgacctgga ggctcgccaa gctatgcagg
     1021 aacagttgtc taagaacaaa gaactgacac agaaactcca ggtagcctct gagagtgagg
     1081 aagaggaggg aggcacagaa gatgtggaag aactccttgt ccctgatgta gtgaatgaag
     1141 tgcagatgaa tgcagatggg ccgaatccct ggatgctcag gagctgcacc agtgacacca
     1201 aagaggctgc aacccaggag gaccctgagc aactgccaga gcttgaggcc catggagttt
     1261 ctgaaagtga gggagaagaa agaccagtgg cagaagaaga aattttgttg agagaatttg
     1321 aggaaaggcg atcccttaga aaaagatctg agctcagcca agatgctgag ccagcaggca
     1381 gtcaagaaac aaaagattct ggcagccagg aggtgctgtc tgaattgaga gtactatctc
     1441 agaaattgaa ggaaaaccat cagtccagga agcaaaaagc aagttcagag gggactattc
     1501 cccaggtcca gagagaggaa cctgccccag aagaagagga gcccctgttg ctacagagac
     1561 cagagagagt acagacgctg gaagagctag aagagctggg aaaagaagaa tgttttcaaa
     1621 ataaggagct tcccagacct gtgttagaag ggcagcagtc agagaggacc ccaaataatc
     1681 gccctgatgc ccctaaggag aagaaaaaga aggagcaaat gatcgaccta cagaacctcc
     1741 taaccacaca atctccctcc gtgaagtctt tggcagttcc cacaatagag gagctggaag
     1801 atgaagagga gagaaaccat aggcagatga taaaggaagc ttttgctggg gatgatgtca
     1861 tcagagattt cttgaaagag aagagggaag ctgtggaggc gagtaagcca aaggacgtgg
     1921 acctgacact acctggctgg ggcgagtggg gtggtgtggg cctaaagccc agtgccaaga
     1981 aaagacgccg gtttctcatt aaagcccctg agggtcctcc aagaaaagat aagaatttgc
     2041 caaatgtgat tatcaatgag aagcgcaaca tccacgcagc tgctcatcag gtacgagtgc
     2101 ttccatatcc atttacccac cattggcaat ttgaaaggac catccagacc cccataggat
     2161 ccacatggaa cacccagagg gctttccaaa agctgactac tcccaaggtc gtcaccaagc
     2221 caggccatat cattaacccc ataaaagcag aagacgtggg ctaccggtct tcctcaaggt
     2281 cggacctgtc tgtcatacag aggaatccaa aacgaatcac cacacgtcac aaaaaacagc
     2341 tgaagaaatg ctctgtagat tgagttgctg gaggagtgac agccaggagc cctgacttca
     2401 cttcctttgg tccagtttta ctctgataca gggtggattc caaaactggc tcagtacatt
     2461 gcatgtagtt aagccacatt ttaaaaataa aggcattttt taatcta
//
