LOCUS       NM_016037               2023 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens UTP11 small subunit processome component (UTP11),
            mRNA.
ACCESSION   NM_016037
VERSION     NM_016037.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2023)
  AUTHORS   Chen,Y., Zhang,X., Zhang,M., Fan,W., Lin,Y. and Li,G.
  TITLE     UTP11 promotes the growth of hepatocellular carcinoma by enhancing
            the mRNA stability of Oct4
  JOURNAL   BMC Cancer 24 (1), 93 (2024)
   PUBMED   38233795
  REMARK    GeneRIF: UTP11 promotes the growth of hepatocellular carcinoma by
            enhancing the mRNA stability of Oct4.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2023)
  AUTHORS   Gan,Y., Deng,J., Hao,Q., Huang,Y., Han,T., Xu,J.G., Zhao,M.,
            Yao,L., Xu,Y., Xiong,J., Lu,H., Wang,C., Chen,J. and Zhou,X.
  TITLE     UTP11 deficiency suppresses cancer development via nucleolar stress
            and ferroptosis
  JOURNAL   Redox Biol 62, 102705 (2023)
   PUBMED   37087976
  REMARK    GeneRIF: UTP11 deficiency suppresses cancer development via
            nucleolar stress and ferroptosis.
REFERENCE   3  (bases 1 to 2023)
  AUTHORS   Singh,S., Vanden Broeck,A., Miller,L., Chaker-Margot,M. and
            Klinge,S.
  TITLE     Nucleolar maturation of the human small subunit processome
  JOURNAL   Science 373 (6560), eabj5338 (2021)
   PUBMED   34516797
REFERENCE   4  (bases 1 to 2023)
  AUTHORS   Baltz,A.G., Munschauer,M., Schwanhausser,B., Vasile,A.,
            Murakawa,Y., Schueler,M., Youngs,N., Penfold-Brown,D., Drew,K.,
            Milek,M., Wyler,E., Bonneau,R., Selbach,M., Dieterich,C. and
            Landthaler,M.
  TITLE     The mRNA-bound proteome and its global occupancy profile on
            protein-coding transcripts
  JOURNAL   Mol Cell 46 (5), 674-690 (2012)
   PUBMED   22681889
REFERENCE   5  (bases 1 to 2023)
  AUTHORS   Castello,A., Fischer,B., Eichelbaum,K., Horos,R., Beckmann,B.M.,
            Strein,C., Davey,N.E., Humphreys,D.T., Preiss,T., Steinmetz,L.M.,
            Krijgsveld,J. and Hentze,M.W.
  TITLE     Insights into RNA biology from an atlas of mammalian mRNA-binding
            proteins
  JOURNAL   Cell 149 (6), 1393-1406 (2012)
   PUBMED   22658674
REFERENCE   6  (bases 1 to 2023)
  AUTHORS   Andersen,J.S., Lam,Y.W., Leung,A.K., Ong,S.E., Lyon,C.E.,
            Lamond,A.I. and Mann,M.
  TITLE     Nucleolar proteome dynamics
  JOURNAL   Nature 433 (7021), 77-83 (2005)
   PUBMED   15635413
REFERENCE   7  (bases 1 to 2023)
  AUTHORS   Heese,K., Nagai,Y. and Sawada,T.
  TITLE     Comparative gene identification-94--a pivotal regulator of
            apoptosis
  JOURNAL   Neuroscience 116 (2), 321-324 (2003)
   PUBMED   12559088
REFERENCE   8  (bases 1 to 2023)
  AUTHORS   Andersen,J.S., Lyon,C.E., Fox,A.H., Leung,A.K., Lam,Y.W., Steen,H.,
            Mann,M. and Lamond,A.I.
  TITLE     Directed proteomic analysis of the human nucleolus
  JOURNAL   Curr Biol 12 (1), 1-11 (2002)
   PUBMED   11790298
REFERENCE   9  (bases 1 to 2023)
  AUTHORS   Heese,K., Nakayama,T., Hata,R., Masumura,M., Akatsu,H., Li,F.,
            Nagai,Y., Yamamoto,T., Kosaka,K., Suemoto,T. and Sawada,T.
  TITLE     Characterizing CGI-94 (comparative gene identification-94) which is
            down-regulated in the hippocampus of early stage Alzheimer's
            disease brain
  JOURNAL   Eur J Neurosci 15 (1), 79-86 (2002)
   PUBMED   11860508
  REMARK    GeneRIF: CGI-94 is down-regulated at the mRNA level in the
            hippocampus of early stage AD brain
REFERENCE   10 (bases 1 to 2023)
  AUTHORS   Robertson,N.G., Khetarpal,U., Gutierrez-Espeleta,G.A., Bieber,F.R.
            and Morton,C.C.
  TITLE     Isolation of novel and known genes from a human fetal cochlear cDNA
            library using subtractive hybridization and differential screening
  JOURNAL   Genomics 23 (1), 42-50 (1994)
   PUBMED   7829101
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BU940926.1, AF151852.1, CX163866.1, BU620078.1 and BI493106.1.
            
            On Nov 22, 2018 this sequence version replaced NM_016037.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.732910.1,
                                           SRR3476690.573458.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000373014.5/ ENSP00000362105.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-130               BU940926.1         26-155
            131-1025            AF151852.1         131-1025
            1026-1479           CX163866.1         414-867
            1480-1616           BU620078.1         431-567             c
            1617-2023           BI493106.1         12-418              c
FEATURES             Location/Qualifiers
     source          1..2023
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p34.3"
     gene            1..2023
                     /gene="UTP11"
                     /gene_synonym="CGI-94; CGI94; UTP11L"
                     /note="UTP11 small subunit processome component"
                     /db_xref="GeneID:51118"
                     /db_xref="HGNC:HGNC:24329"
                     /db_xref="MIM:609440"
     exon            1..132
                     /gene="UTP11"
                     /gene_synonym="CGI-94; CGI94; UTP11L"
                     /inference="alignment:Splign:2.1.0"
     CDS             70..831
                     /gene="UTP11"
                     /gene_synonym="CGI-94; CGI94; UTP11L"
                     /note="UTP11-like protein; U3 snoRNA-associated protein
                     11; UTP11-like, U3 small nucleolar ribonucleoprotein;
                     UTP11, small subunit processome component homolog"
                     /codon_start=1
                     /product="probable U3 small nucleolar RNA-associated
                     protein 11"
                     /protein_id="NP_057121.2"
                     /db_xref="CCDS:CCDS429.1"
                     /db_xref="GeneID:51118"
                     /db_xref="HGNC:HGNC:24329"
                     /db_xref="MIM:609440"
                     /translation="MAAAFRKAAKSRQREHRERSQPGFRKHLGLLEKKKDYKLRADDY
                     RKKQEYLKALRKKALEKNPDEFYYKMTRVKLQDGVHIIKETKEEVTPEQLKLMRTQDV
                     KYIEMKRVAEAKKIERLKSELHLLDFQGKQQNKHVFFFDTKKEVEQFDVATHLQTAPE
                     LVDRVFNRPRIETLQKEKVKGVTNQTGLKRIAKERQKQYNCLTQRIEREKKLFVIAQK
                     IQTRKDLMDKTQKVKVKKETVNSPAIYKFQSRRKR"
     exon            133..194
                     /gene="UTP11"
                     /gene_synonym="CGI-94; CGI94; UTP11L"
                     /inference="alignment:Splign:2.1.0"
     exon            195..297
                     /gene="UTP11"
                     /gene_synonym="CGI-94; CGI94; UTP11L"
                     /inference="alignment:Splign:2.1.0"
     exon            298..411
                     /gene="UTP11"
                     /gene_synonym="CGI-94; CGI94; UTP11L"
                     /inference="alignment:Splign:2.1.0"
     exon            412..505
                     /gene="UTP11"
                     /gene_synonym="CGI-94; CGI94; UTP11L"
                     /inference="alignment:Splign:2.1.0"
     exon            506..636
                     /gene="UTP11"
                     /gene_synonym="CGI-94; CGI94; UTP11L"
                     /inference="alignment:Splign:2.1.0"
     exon            637..747
                     /gene="UTP11"
                     /gene_synonym="CGI-94; CGI94; UTP11L"
                     /inference="alignment:Splign:2.1.0"
     exon            748..2023
                     /gene="UTP11"
                     /gene_synonym="CGI-94; CGI94; UTP11L"
                     /inference="alignment:Splign:2.1.0"
     regulatory      983..988
                     /regulatory_class="polyA_signal_sequence"
                     /gene="UTP11"
                     /gene_synonym="CGI-94; CGI94; UTP11L"
                     /note="hexamer: ATTAAA"
     polyA_site      1006
                     /gene="UTP11"
                     /gene_synonym="CGI-94; CGI94; UTP11L"
                     /note="major polyA site"
     regulatory      2003..2008
                     /regulatory_class="polyA_signal_sequence"
                     /gene="UTP11"
                     /gene_synonym="CGI-94; CGI94; UTP11L"
                     /note="hexamer: AATAAA"
     polyA_site      2023
                     /gene="UTP11"
                     /gene_synonym="CGI-94; CGI94; UTP11L"
ORIGIN      
        1 agtggacttg gcggcagagg cagtgcggat ccggcgttct ccactgatct tttccaaggc
       61 tgtacagaca tggcggcggc ttttcggaag gcggctaagt cccggcagcg ggaacacaga
      121 gagcgaagcc agcctggctt tcgaaaacat ctgggcctgc tggagaaaaa gaaagattac
      181 aaacttcgtg cagatgacta ccgtaaaaaa caagaatacc tcaaagctct tcggaagaag
      241 gctcttgaaa aaaatccaga tgaattctac tacaaaatga ctcgggttaa actccaggat
      301 ggagtacata ttattaagga gactaaggaa gaagtaaccc cagaacaact aaagctgatg
      361 agaactcagg acgtcaaata tatagaaatg aagagggttg cagaagctaa gaaaatcgaa
      421 agactaaaat cagagctcca tctgctggat ttccagggga agcaacagaa caagcatgtg
      481 ttcttttttg acaccaaaaa ggaagttgaa cagtttgatg tcgcaactca cctgcaaaca
      541 gccccggagc tagtcgacag agtctttaat aggcccagga tagagacctt gcagaaagaa
      601 aaagtgaaag gagttaccaa tcagactgga cttaagcgaa tagctaaaga aaggcaaaag
      661 cagtataact gcctgacaca gcggattgaa cgagagaaga aattgttcgt tattgctcag
      721 aaaattcaaa cacgcaaaga tcttatggat aaaactcaga aagtgaaggt gaagaaagaa
      781 acggtgaact ccccagctat ttataaattt cagagtcgtc gaaaacgttg acgtgttata
      841 gataagcctt gtcattctgt atcaaaaatc tgttgtcgtt ttctagtaac ttcaaattcc
      901 attactccaa atggcatggt tttccggttt gtaaccataa ctaaattgtc agtctgacat
      961 ttaatgtctt tctatggaca acattaaatc tccctccctt ctgtaattgt ttttggattg
     1021 tgaaattagt cttattttta tatacttaat tttttttttc tttgagatag ggtctttgtt
     1081 gccaggctgg aagtgcagtg tgtgattatg gctcactgca actttgaact cctgggctca
     1141 agtgatcttc ctgcatcagc ctcttgagta gctgggacca cagacatgtg ccaccatgtc
     1201 tgagtaatgt ttaaattttc tgtagagacc aggttttgcc atgttggcca ggctggtttt
     1261 gaactcgtgg cctcaagcga tcctcccacc ttggcctccc aaagggctgg gattacaggg
     1321 atgagccact atgcccagcc cataattttt tttgttatga aacataggat ctcattacag
     1381 cagatttgga aagtagatta attcattcct aatcccagtg cttattcaat aataacaaat
     1441 atttattgca tgcttaactg tgctaggagc tagagctgtg gaggtggaca attactgtga
     1501 gtagtctagt tgatttcctc cattttgtaa aacgaggcat cactttttgt ccatgttttt
     1561 gtgttttata gttacagtaa acaatttgat gtcctacttt tttttttttt ttttttgaga
     1621 cggagtctcg ctctgtcgcc caggccggac tgcggactgc agtggcgcaa tctcggctca
     1681 ctgcaagctc cgcttcccgg gttcacgcca ttctcctgcc tcagcctccc gagtagctgg
     1741 gactacaggc gcccgccacc gcgcctggct aatttttttt tgtatttttt tagtagagac
     1801 ggggtttcac cttgttagcc aggatggtct cgatctcctg acctcatgat ccacccgcct
     1861 cggcctccca aagtgctggg attacaggcg tgagccaccg cgcccggccg atgtcctact
     1921 ttttaattaa atcattagct ctttcccagt ttgttacatc acaaaagttt tttacagtaa
     1981 tatatgctag agtaaacgtt aaaataaata ttatttttaa tga
//
