LOCUS       NM_003577               1214 bp    mRNA    linear   PRI 23-MAR-2024
DEFINITION  Homo sapiens undifferentiated embryonic cell transcription factor 1
            (UTF1), mRNA.
ACCESSION   NM_003577
VERSION     NM_003577.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1214)
  AUTHORS   Roshan,M.M., Azizi,H., Majelan,M.A. and Tabar,A.N.
  TITLE     Sox9 downregulation in non-obstructive azoospermia by UTF1 and
            mediator role of POU5F1
  JOURNAL   BMC Res Notes 17 (1), 77 (2024)
   PUBMED   38486279
  REMARK    GeneRIF: Sox9 downregulation in non-obstructive azoospermia by UTF1
            and mediator role of POU5F1.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1214)
  AUTHORS   Correa-Vazquez,J.F., Juarez-Vicente,F., Garcia-Gutierrez,P.,
            Barysch,S.V., Melchior,F. and Garcia-Dominguez,M.
  TITLE     The Sumo proteome of proliferating and neuronal-differentiating
            cells reveals Utf1 among key Sumo targets involved in neurogenesis
  JOURNAL   Cell Death Dis 12 (4), 305 (2021)
   PUBMED   33753728
  REMARK    GeneRIF: The Sumo proteome of proliferating and
            neuronal-differentiating cells reveals Utf1 among key Sumo targets
            involved in neurogenesis.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1214)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 1214)
  AUTHORS   Mouallif,M., Albert,A., Zeddou,M., Ennaji,M.M., Delvenne,P. and
            Guenin,S.
  TITLE     Expression profile of undifferentiated cell transcription factor 1
            in normal and cancerous human epithelia
  JOURNAL   Int J Exp Pathol 95 (4), 251-259 (2014)
   PUBMED   24738751
REFERENCE   5  (bases 1 to 1214)
  AUTHORS   Pantazis,G., Harter,P.N., Capper,D., Kohlhof,P., Mittelbronn,M. and
            Schittenhelm,J.
  TITLE     The embryonic stem cell factor UTF1 serves as a reliable diagnostic
            marker for germinomas
  JOURNAL   Pathology 46 (3), 225-229 (2014)
   PUBMED   24614704
  REMARK    GeneRIF: With a sensitivity of 100% and a specificity of 97% in the
            detection of central nervous system (CNS) germinomas, UTF1 serves
            as a new reliable alternative in the diagnostic setting of CNS germ
            cell tumours.
REFERENCE   6  (bases 1 to 1214)
  AUTHORS   Kooistra,S.M., Thummer,R.P. and Eggen,B.J.
  TITLE     Characterization of human UTF1, a chromatin-associated protein with
            repressor activity expressed in pluripotent cells
  JOURNAL   Stem Cell Res 2 (3), 211-218 (2009)
   PUBMED   19393592
  REMARK    GeneRIF: Human UTF1 is a tightly DNA-associated protein with
            transcriptional repressor activity.
REFERENCE   7  (bases 1 to 1214)
  AUTHORS   Zhao,Y., Yin,X., Qin,H., Zhu,F., Liu,H., Yang,W., Zhang,Q.,
            Xiang,C., Hou,P., Song,Z., Liu,Y., Yong,J., Zhang,P., Cai,J.,
            Liu,M., Li,H., Li,Y., Qu,X., Cui,K., Zhang,W., Xiang,T., Wu,Y.,
            Zhao,Y., Liu,C., Yu,C., Yuan,K., Lou,J., Ding,M. and Deng,H.
  TITLE     Two supporting factors greatly improve the efficiency of human iPSC
            generation
  JOURNAL   Cell Stem Cell 3 (5), 475-479 (2008)
   PUBMED   18983962
  REMARK    GeneRIF: enhances reprogramming efficiency of pluripotent stem
            cells generation induced from human adult fibroblasts
REFERENCE   8  (bases 1 to 1214)
  AUTHORS   Kristensen,D.M., Nielsen,J.E., Skakkebaek,N.E., Graem,N.,
            Jacobsen,G.K., Rajpert-De Meyts,E. and Leffers,H.
  TITLE     Presumed pluripotency markers UTF-1 and REX-1 are expressed in
            human adult testes and germ cell neoplasms
  JOURNAL   Hum Reprod 23 (4), 775-782 (2008)
   PUBMED   18281244
  REMARK    GeneRIF: The expression pattern indicated that UTF-1 plays a
            possible role in spermatogonial self-renewal
REFERENCE   9  (bases 1 to 1214)
  AUTHORS   Nishimoto,M., Fukushima,A., Miyagi,S., Suzuki,Y., Sugano,S.,
            Matsuda,Y., Hori,T., Muramatsu,M. and Okuda,A.
  TITLE     Structural analyses of the UTF1 gene encoding a transcriptional
            coactivator expressed in pluripotent embryonic stem cells
  JOURNAL   Biochem Biophys Res Commun 285 (4), 945-953 (2001)
   PUBMED   11467843
REFERENCE   10 (bases 1 to 1214)
  AUTHORS   Fukushima,A., Okuda,A., Nishimoto,M., Seki,N., Hori,T.A. and
            Muramatsu,M.
  TITLE     Characterization of functional domains of an embryonic stem cell
            coactivator UTF1 which are conserved and essential for potentiation
            of ATF-2 activity
  JOURNAL   J Biol Chem 273 (40), 25840-25849 (1998)
   PUBMED   9748258
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL445199.37 and AY606112.1.
            
            On Nov 23, 2018 this sequence version replaced NM_003577.2.
            
            Summary: The protein encoded by this gene is a leucine
            zipper-containing transcriptional coactivator that may link the
            upstream activator ATF2 with the basal transcription complex. The
            encoded protein is closely associated with chromatin and is
            required for the proper differentiation of embryonic carcinoma and
            embryonic stem cells. Found nearly exclusively in pluripotent
            cells, this protein can also serve as a transcriptional repressor.
            [provided by RefSeq, Nov 2015].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB011076.2, AY606112.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2155751 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000304477.3/ ENSP00000305906.2
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-57                AL445199.37        199300-199356
            58-1214             AY606112.1         1-1157
FEATURES             Location/Qualifiers
     source          1..1214
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10q26.3"
     gene            1..1214
                     /gene="UTF1"
                     /note="undifferentiated embryonic cell transcription
                     factor 1"
                     /db_xref="GeneID:8433"
                     /db_xref="HGNC:HGNC:12634"
                     /db_xref="MIM:604130"
     exon            1..622
                     /gene="UTF1"
                     /inference="alignment:Splign:2.1.0"
     CDS             73..1098
                     /gene="UTF1"
                     /codon_start=1
                     /product="undifferentiated embryonic cell transcription
                     factor 1"
                     /protein_id="NP_003568.2"
                     /db_xref="CCDS:CCDS31318.1"
                     /db_xref="GeneID:8433"
                     /db_xref="HGNC:HGNC:12634"
                     /db_xref="MIM:604130"
                     /translation="MLLRPRRPPPLAPPAPPSPASPDPEPRTPGDAPGTPPRRPASPS
                     ALGELGLPVSPGSAQRTPWSARETELLLGTLLQPAVWRALLLDRRQALPTYRRVSAAL
                     AQQQVRRTPAQCRRRYKFLKDKFREAHGQPPGPFDEQIRKLMGLLGDNGRKRPRRRSP
                     GSGRPQRARRPVPNAHAPAPSEPDATPLPTARDRDADPTWTLRFSPSPPKSADASPAP
                     GSPPAPAPTALATCIPEDRAPVRGPGSPPPPPAREDPDSPPGRPEDCAPPPAAPPSLN
                     TALLQTLGHLGDIANILGPLRDQLLTLNQHVEQLRGAFDQTVSLAVGFILGSAAAERG
                     VLRDPCQ"
     exon            623..1214
                     /gene="UTF1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1192..1197
                     /regulatory_class="polyA_signal_sequence"
                     /gene="UTF1"
                     /note="hexamer: AATAAA"
     polyA_site      1214
                     /gene="UTF1"
                     /note="major polyA site"
ORIGIN      
        1 agaacgcgtg tgggcggccc gggcggcgtc tggccctctc cccatcctcg cgcgccgcgc
       61 cccagccccg ggatgctgct ccggccccgc aggccgcccc cgctcgcgcc ccccgcgccg
      121 ccctcgcccg ccagccccga ccccgagccg cggacacccg gagacgcccc ggggaccccg
      181 ccccggaggc ccgcctcgcc cagcgcgctg ggggaactcg ggttgccggt gtccccgggc
      241 tcggcgcagc gcacgccctg gagcgcccgg gagacggagc tgctgctggg gacgctgctg
      301 caaccggccg tgtggcgcgc gctgctcctg gaccgccgcc aggccctgcc cacctaccgc
      361 cgcgtgtcgg ccgcgctggc ccagcagcag gtgcgccgca cccccgcgca gtgccgccgc
      421 cgctacaagt tccttaaaga caagtttcgc gaggcgcacg gccagccgcc cgggcccttc
      481 gacgagcaga tccggaagct catggggctg ctgggcgaca acgggcgcaa acggcctcgc
      541 cgccgctccc cggggtccgg gcgcccccag cgcgcccgcc gcccggtccc caacgcgcac
      601 gcgccggctc ccagcgaacc agacgccacc ccgctgccca ccgcccgcga ccgcgacgcg
      661 gaccccacct ggacgctccg cttcagcccg tccccaccga agtctgcgga cgcctccccc
      721 gcccccggct ccccgccagc tcccgccccg accgccctcg ccacctgcat ccccgaggac
      781 cgcgcgcccg tccgcggccc cgggtccccg ccgccacccc cggcccgcga agaccccgac
      841 tcgccgcccg gccgccccga ggactgcgcg ccccctccgg ccgcgccccc gtcgctgaac
      901 accgccctgc tgcagaccct ggggcacctg ggcgacatcg cgaacatcct gggcccgctg
      961 cgcgaccagc tgctgacctt gaaccagcac gtggagcagc tgcgcggcgc cttcgaccag
     1021 acagtgtccc tggccgtggg cttcattctg ggcagcgcgg ccgccgagcg aggggtcctc
     1081 agggacccgt gccagtgagt cccggctgcg gccagtctcc cctctccagg ccgaggcccc
     1141 tccgccctga cccctcctgc tgccttccca cccccgttct tgggtatgtt caataaaagg
     1201 attgttttcc taga
//
