LOCUS       NM_005800               4894 bp    mRNA    linear   PRI 11-FEB-2025
DEFINITION  Homo sapiens ubiquitin specific peptidase like 1 (USPL1),
            transcript variant 1, mRNA.
ACCESSION   NM_005800
VERSION     NM_005800.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4894)
  AUTHORS   Viard,J., Loe-Mie,Y., Daudin,R., Khelfaoui,M., Plancon,C.,
            Boland,A., Tejedor,F., Huganir,R.L., Kim,E., Kinoshita,M., Liu,G.,
            Haucke,V., Moncion,T., Yu,E., Hindie,V., Blehaut,H., Mircher,C.,
            Herault,Y., Deleuze,J.F., Rain,J.C., Simonneau,M. and
            Lepagnol-Bestel,A.M.
  TITLE     Chr21 protein-protein interactions: enrichment in proteins involved
            in intellectual disability, autism, and late-onset Alzheimer's
            disease
  JOURNAL   Life Sci Alliance 5 (12), e202101205 (2022)
   PUBMED   35914814
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4894)
  AUTHORS   Li,Y., Varejao,N. and Reverter,D.
  TITLE     Structural basis for the SUMO protease activity of the atypical
            ubiquitin-specific protease USPL1
  JOURNAL   Nat Commun 13 (1), 1819 (2022)
   PUBMED   35383180
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4894)
  AUTHORS   Hutten,S., Chachami,G., Winter,U., Melchior,F. and Lamond,A.I.
  TITLE     A role for the Cajal-body-associated SUMO isopeptidase USPL1 in
            snRNA transcription mediated by RNA polymerase II
  JOURNAL   J Cell Sci 127 (Pt 5), 1065-1078 (2014)
   PUBMED   24413172
  REMARK    GeneRIF: USPL1 plays a key role in RNAPII-mediated snRNA
            transcription.
REFERENCE   4  (bases 1 to 4894)
  AUTHORS   Bermejo,J.L., Kabisch,M., Dunnebier,T., Schnaidt,S., Melchior,F.,
            Fischer,H.P., Harth,V., Rabstein,S., Pesch,B., Bruning,T.,
            Justenhoven,C., Brauch,H., Baisch,C., Ko,Y.D. and Hamann,U.
  TITLE     Exploring the association between genetic variation in the SUMO
            isopeptidase gene USPL1 and breast cancer through integration of
            data from the population-based GENICA study and external genetic
            databases
  JOURNAL   Int J Cancer 133 (2), 362-372 (2013)
   PUBMED   23338788
  REMARK    GeneRIF: genetic variability in USPL1 may have a role in breast
            cancer, especially in rs7984952
REFERENCE   5  (bases 1 to 4894)
  AUTHORS   Schulz,S., Chachami,G., Kozaczkiewicz,L., Winter,U.,
            Stankovic-Valentin,N., Haas,P., Hofmann,K., Urlaub,H., Ovaa,H.,
            Wittbrodt,J., Meulmeester,E. and Melchior,F.
  TITLE     Ubiquitin-specific protease-like 1 (USPL1) is a SUMO isopeptidase
            with essential, non-catalytic functions
  JOURNAL   EMBO Rep 13 (10), 930-938 (2012)
   PUBMED   22878415
REFERENCE   6  (bases 1 to 4894)
  AUTHORS   Bohm,D., Keller,K., Pieter,J., Boehm,N., Wolters,D., Siggelkow,W.,
            Lebrecht,A., Schmidt,M., Kolbl,H., Pfeiffer,N. and Grus,F.H.
  TITLE     Comparison of tear protein levels in breast cancer patients and
            healthy controls using a de novo proteomic approach
  JOURNAL   Oncol Rep 28 (2), 429-438 (2012)
   PUBMED   22664934
REFERENCE   7  (bases 1 to 4894)
  AUTHORS   Wang,J., Huo,K., Ma,L., Tang,L., Li,D., Huang,X., Yuan,Y., Li,C.,
            Wang,W., Guan,W., Chen,H., Jin,C., Wei,J., Zhang,W., Yang,Y.,
            Liu,Q., Zhou,Y., Zhang,C., Wu,Z., Xu,W., Zhang,Y., Liu,T., Yu,D.,
            Zhang,Y., Chen,L., Zhu,D., Zhong,X., Kang,L., Gan,X., Yu,X., Ma,Q.,
            Yan,J., Zhou,L., Liu,Z., Zhu,Y., Zhou,T., He,F. and Yang,X.
  TITLE     Toward an understanding of the protein interaction network of the
            human liver
  JOURNAL   Mol Syst Biol 7, 536 (2011)
   PUBMED   21988832
  REMARK    Erratum:[Mol Syst Biol. 2017 Dec 18;13(12):965. doi:
            10.15252/msb.20178107.. PMID: 29254952]
            Publication Status: Online-Only
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BI752017.1, X59131.1, BC036027.1, AK289826.1 and AL138681.17.
            
            On Nov 22, 2018 this sequence version replaced NM_005800.4.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660807.175383.1,
                                           SRR1803615.158261.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000255304.9/ ENSP00000255304.4
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-28                BI752017.1         228-255
            29-1624             X59131.1           1-1596
            1625-2427           BC036027.1         1624-2426
            2428-3608           AK289826.1         2411-3591
            3609-3677           X59131.1           3581-3649
            3678-4894           AL138681.17        85059-86275
FEATURES             Location/Qualifiers
     source          1..4894
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="13"
                     /map="13q12.3"
     gene            1..4894
                     /gene="USPL1"
                     /gene_synonym="bA121O19.1; C13orf22; D13S106E"
                     /note="ubiquitin specific peptidase like 1"
                     /db_xref="GeneID:10208"
                     /db_xref="HGNC:HGNC:20294"
                     /db_xref="MIM:617470"
     exon            1..137
                     /gene="USPL1"
                     /gene_synonym="bA121O19.1; C13orf22; D13S106E"
                     /inference="alignment:Splign:2.1.0"
     exon            138..304
                     /gene="USPL1"
                     /gene_synonym="bA121O19.1; C13orf22; D13S106E"
                     /inference="alignment:Splign:2.1.0"
     CDS             206..3484
                     /gene="USPL1"
                     /gene_synonym="bA121O19.1; C13orf22; D13S106E"
                     /note="isoform 1 is encoded by transcript variant 1;
                     highly charged protein; ubiquitin-specific peptidase-like
                     protein 1; SUMO-specific isopeptidase USPL1; USP-like 1"
                     /codon_start=1
                     /product="SUMO-specific isopeptidase USPL1 isoform 1"
                     /protein_id="NP_005791.3"
                     /db_xref="CCDS:CCDS9336.1"
                     /db_xref="GeneID:10208"
                     /db_xref="HGNC:HGNC:20294"
                     /db_xref="MIM:617470"
                     /translation="MMDSPKIGNGLPVIGPGTDIGISSLHMVGYLGKNFDSAKVPSDE
                     YCPACREKGKLKALKTYRISFQESIFLCEDLQCIYPLGSKSLNNLISPDLEECHTPHK
                     PQKRKSLESSYKDSLLLANSKKTRNYIAIDGGKVLNSKHNGEVYDETSSNLPDSSGQQ
                     NPIRTADSLERNEILEADTVDMATTKDPATVDVSGTGRPSPQNEGCTSKLEMPLESKC
                     TSFPQALCVQWKNAYALCWLDCILSALVHSEELKNTVTGLCSKEESIFWRLLTKYNQA
                     NTLLYTSQLSGVKDGDCKKLTSEIFAEIETCLNEVRDEIFISLQPQLRCTLGDMESPV
                     FAFPLLLKLETHIEKLFLYSFSWDFECSQCGHQYQNRHMKSLVTFTNVIPEWHPLNAA
                     HFGPCNNCNSKSQIRKMVLEKVSPIFMLHFVEGLPQNDLQHYAFHFEGCLYQITSVIQ
                     YRANNHFITWILDADGSWLECDDLKGPCSERHKKFEVPASEIHIVIWERKISQVTDKE
                     AACLPLKKTNDQHALSNEKPVSLTSCSVGDAASAETASVTHPKDISVAPRTLSQDTAV
                     THGDHLLSGPKGLVDNILPLTLEETIQKTASVSQLNSEAFLLENKPVAENTGILKTNT
                     LLSQESLMASSVSAPCNEKLIQDQFVDISFPSQVVNTNMQSVQLNTEDTVNTKSVNNT
                     DATGLIQGVKSVEIEKDAQLKQFLTPKTEQLKPERVTSQVSNLKKKETTADSQTTTSK
                     SLQNQSLKENQKKPFVGSWVKGLISRGASFMPLCVSAHNRNTITDLQPSVKGVNNFGG
                     FKTKGINQKASHVSKKARKSASKPPPISKPPAGPPSSNGTAAHPHAHAASEVLEKSGS
                     TSCGAQLNHSSYGNGISSANHEDLVEGQIHKLRLKLRKKLKAEKKKLAALMSSPQSRT
                     VRSENLEQVPQDGSPNDCESIEDLLNELPYPIDIASESACTTVPGVSLYSSQTHEEIL
                     AELLSPTPVSTELSENGEGDFRYLGMGDSHIPPPVPSEFNDVSQNTHLRQDHNYCSPT
                     KKNPCEVQPDSLTNNACVRTLNLESPMKTDIFDEFFSSSALNALANDTLDLPHFDEYL
                     FENY"
     exon            305..433
                     /gene="USPL1"
                     /gene_synonym="bA121O19.1; C13orf22; D13S106E"
                     /inference="alignment:Splign:2.1.0"
     exon            434..1073
                     /gene="USPL1"
                     /gene_synonym="bA121O19.1; C13orf22; D13S106E"
                     /inference="alignment:Splign:2.1.0"
     exon            1074..1187
                     /gene="USPL1"
                     /gene_synonym="bA121O19.1; C13orf22; D13S106E"
                     /inference="alignment:Splign:2.1.0"
     exon            1188..1317
                     /gene="USPL1"
                     /gene_synonym="bA121O19.1; C13orf22; D13S106E"
                     /inference="alignment:Splign:2.1.0"
     exon            1318..1443
                     /gene="USPL1"
                     /gene_synonym="bA121O19.1; C13orf22; D13S106E"
                     /inference="alignment:Splign:2.1.0"
     exon            1444..1601
                     /gene="USPL1"
                     /gene_synonym="bA121O19.1; C13orf22; D13S106E"
                     /inference="alignment:Splign:2.1.0"
     exon            1602..4894
                     /gene="USPL1"
                     /gene_synonym="bA121O19.1; C13orf22; D13S106E"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3658..3663
                     /regulatory_class="polyA_signal_sequence"
                     /gene="USPL1"
                     /gene_synonym="bA121O19.1; C13orf22; D13S106E"
                     /note="hexamer: ATTAAA"
     polyA_site      3677
                     /gene="USPL1"
                     /gene_synonym="bA121O19.1; C13orf22; D13S106E"
                     /note="major polyA site"
     regulatory      4874..4879
                     /regulatory_class="polyA_signal_sequence"
                     /gene="USPL1"
                     /gene_synonym="bA121O19.1; C13orf22; D13S106E"
                     /note="hexamer: AATAAA"
     polyA_site      4894
                     /gene="USPL1"
                     /gene_synonym="bA121O19.1; C13orf22; D13S106E"
ORIGIN      
        1 gccttcctag tggagacgcg agtgggggag gagcagtccg aggggaacgt gggttgaacg
       61 ttgcaactag ggtggagatc aagctggaac aggagttccg atcgacccgg taccaagaag
      121 gggagtgccc gcggcagggt tcattgaaaa aatccttagt gatattgaca tgtctcaagt
      181 gacataaatt agccaatgac tcggaatgat ggattctccg aagattggaa atggtttgcc
      241 agtgattgga ccagggactg atatagggat atcttcactc cacatggtgg ggtatttggg
      301 aaaaaatttt gattcagcta aagttccatc agatgagtat tgccctgctt gtagagagaa
      361 gggaaagtta aaagccttaa agacttaccg aattagtttt caagaatcta tctttttgtg
      421 tgaggatctg cagtgcatct atcctttggg ctctaaatca cttaataacc taatttctcc
      481 tgatttggaa gaatgtcaca ctccacataa gcctcagaaa aggaagagct tagaaagcag
      541 ctataaggat tcacttcttt tagcaaattc caaaaagact agaaattata ttgctattga
      601 cggtggaaaa gttttgaaca gcaaacataa tggagaagta tatgacgaaa cctcgtcaaa
      661 cttacctgat agtagtggtc aacagaatcc aattaggaca gctgattcct tggagcggaa
      721 tgagattttg gaagctgata ctgttgacat ggctactaca aaagatcctg ctacagttga
      781 tgtctctgga actggcagac cttcccctca aaatgaagga tgtacatcta aactggaaat
      841 gccactggag agcaaatgta catcatttcc ccaggcttta tgtgtccagt ggaaaaatgc
      901 ttatgctctc tgttggttag actgtatcct gtcagctttg gtgcactcgg aagagttaaa
      961 gaacaccgtg actggactgt gctcgaagga ggaatctata ttctggcggt tgcttacaaa
     1021 atataatcaa gcaaatacac ttctatatac cagtcaattg agtggtgtta aagatggaga
     1081 ttgtaaaaaa cttacctcag aaatatttgc agagatagag acctgtctga atgaagttag
     1141 agatgaaatt tttattagcc ttcagcccca gcttagatgc acattaggtg atatggaaag
     1201 ccctgtgttt gcatttcccc tgctcttaaa actagaaacc cacattgaaa agctcttcct
     1261 atattctttt tcttgggact ttgaatgttc gcagtgtgga caccaatatc aaaacaggca
     1321 tatgaagagt ctggtcacct ttacaaatgt catccctgag tggcacccac ttaatgctgc
     1381 ccattttggt ccatgtaaca attgcaacag taaatcacaa ataagaaaaa tggtattaga
     1441 aaaagtatct cccatattca tgttgcactt tgtagaaggc ttaccacaga atgacttgca
     1501 gcactatgca tttcattttg aaggctgtct ttatcagata acttctgtaa ttcagtatcg
     1561 agcaaataat cattttataa catggatttt agatgctgat ggaagttggc tggaatgtga
     1621 tgacttaaaa ggcccatgtt ctgaaaggca caagaaattt gaagttcctg cttcagagat
     1681 acatattgtt atttgggaaa gaaaaatatc ccaagtgaca gataaagaag ctgcctgcct
     1741 tccacttaaa aagactaatg accaacacgc tctcagtaat gagaaaccag tatctttaac
     1801 atcgtgttct gtgggtgatg ctgcctcagc tgaaacagcc tcagtaactc accctaaaga
     1861 tatatcagtt gcccctcgta ctctttcaca ggacacagct gtaactcatg gagatcattt
     1921 actttcaggt ccaaaaggtt tggttgacaa tattttacct ctgacacttg aagaaactat
     1981 ccagaaaaca gcctcagttt cacagttaaa ttctgaagct ttcctgttag aaaataaacc
     2041 tgtagcagaa aatacaggaa ttctcaaaac caatactttg ctatcacaag aatcactaat
     2101 ggcttcttca gtatcagctc catgtaatga aaagcttatt caagaccaat ttgtggacat
     2161 aagttttcca tcccaagttg taaatacaaa catgcagtca gtacagctga atacagaaga
     2221 tactgtaaat actaaatctg tgaataatac tgatgctact ggtcttatac agggagtgaa
     2281 gtcagtagaa attgagaagg acgctcagtt aaaacaattc cttacaccaa aaactgaaca
     2341 attaaaacca gaacgtgtca catctcaggt atctaatttg aagaaaaaag aaactacagc
     2401 agattctcaa accacaacat ctaagtcatt acagaatcag tctctgaaag aaaatcagaa
     2461 gaagccattt gtgggaagtt gggttaaagg cttaataagc aggggtgctt cttttatgcc
     2521 actctgtgtt tcagctcata atagaaacac tataactgat ttacaacctt cagttaaagg
     2581 ggtaaataat tttggtggct ttaaaactaa aggtataaac cagaaggcca gccacgtatc
     2641 caagaaagct cgtaagagtg caagtaagcc tcctcccatc agtaagccac cagcaggccc
     2701 tccatcgtct aatggcacag ctgcccaccc acatgctcat gctgcttcag aagttttgga
     2761 aaagtctgga agcacctcat gtggagctca actcaaccac agttcttatg ggaatggtat
     2821 ttcttcagca aaccatgaag acttggtgga aggtcagatt cataaacttc gtctaaaact
     2881 tcgtaaaaag ctaaaggcag aaaagaagaa attagctgct cttatgtctt ccccgcaaag
     2941 cagaacagtt cgaagtgaaa atctagaaca ggtgccccag gatgggtctc caaatgattg
     3001 tgaatcaata gaggacttgt taaatgagct accatatcca attgatattg ccagtgagtc
     3061 tgcatgcacc actgttcctg gtgtttccct gtacagtagt caaactcatg aagaaatttt
     3121 agcggaatta ttgtctccta cacctgtttc aacagagctg tcagaaaatg gggaaggtga
     3181 ctttaggtat ttgggaatgg gagatagtca tatcccacca ccagtaccaa gtgaattcaa
     3241 tgatgtttcc cagaacacac atctgagaca ggaccataat tattgtagcc ccaccaagaa
     3301 aaatccatgt gaagttcagc cagactctct gacaaataat gcctgcgtta gaacattaaa
     3361 cttggagagt ccgatgaaga ctgatatttt cgatgagttt ttttcctcct cagcattaaa
     3421 tgctttagca aatgacacat tagacctacc tcatttcgat gaatatctgt ttgagaatta
     3481 ttgaattaat gcttgttaac ttttttcata taatatttat tattattaga agaacttaca
     3541 atgtgttcag gtagtgttta tacactggac ttgtgtaatt acttgtgtaa taaccatgaa
     3601 caaaatgcaa ggtttaacct ttggttctgc ccatgaagca tgtaatcttt cttacacatt
     3661 aaaatcactg aatgtgttct cctttttggt ttcattttgt tcttgtgaga gtatgaggat
     3721 ttcaaaatgt taaagatgaa aagtggcgtc tagtttctga cagtttgtac agttggatgc
     3781 attacatttt tagatttgaa gttttggtta tgttagtgtt atgagtgatc tttgtggtgg
     3841 ttttcttccc ctggaaacct gttgctcgtg gcgctttgcc cacggtgccc gagttcttgt
     3901 cctgtgtcca gatatgcaga caaatgaagg gtgaagaaga agaagaggag ctttatttag
     3961 tgttagaaca gctcagaagg agacccacag tgagcagctc ccctgtgtcg gcgggcaggt
     4021 cgtccctcaa gtgttcagct ctcagcagag aaaaggccct ggagagggtg actcctctca
     4081 gctctcagca gagaagcagc cctggagaag gtagcttctg ttcgcaggca gattgtccag
     4141 aggtcctgct gctctcagac ggggccctgg agaggatagc ttctatccat aggcaggttg
     4201 ttctgccgtc tctacaggtc tctgaagctc ttagcagaga gggtagctcc tccctgttgc
     4261 tggtcgtccc accctctgct cagttctggc tgagcctggg gcattttacg ggcctcgggg
     4321 gaggaagtgc atacttactg gcctggaaaa ggcaccagtt cccactccta caggtgggac
     4381 tggcagcctg gccctcagcc ttcaggccct ccctgttcat ggcttccagg cttacccccc
     4441 tgctttgatc tgagagctgg tgccaatagc agggagaagc caagctgcag aggcaagcac
     4501 ttccgagcct gcaaaagcag gcccccaaaa gtgcagggat gcctgagtct gcacccgcac
     4561 ccaggagggt ggagatcttg cctgctccaa ggctgcagcc ggaatgatag caggctgact
     4621 ggagcacctg ccaccatcat tagttcaaga gtttatgcag atttaagttg tatacggtat
     4681 atgaatgtgt gacagttttc cttatggttg tgtggccttc tgtaagagcc tacgcctgtt
     4741 tgttacaccg gtagagtgct gtggaatgta aactttccct atgtcactta tctcctttat
     4801 ctctccatac agaggagggc aagaaacctt gttacttgaa ctttagtaat gttaagtgat
     4861 caataaatct ataaataaat gatagcagaa aaaa
//
