LOCUS       NM_004654              10036 bp    mRNA    linear   PRI 10-OCT-2024
DEFINITION  Homo sapiens ubiquitin specific peptidase 9 Y-linked (USP9Y), mRNA.
ACCESSION   NM_004654
VERSION     NM_004654.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 10036)
  AUTHORS   Xiu,L., Ma,B. and Ding,L.
  TITLE     Antioncogenic roles of USP9Y and DDX3Y in lung cancer: USP9Y
            stabilizes DDX3Y by preventing its degradation through
            deubiquitination
  JOURNAL   Acta Histochem 126 (1), 152132 (2024)
   PUBMED   38217953
  REMARK    GeneRIF: Antioncogenic roles of USP9Y and DDX3Y in lung cancer:
            USP9Y stabilizes DDX3Y by preventing its degradation through
            deubiquitination.
REFERENCE   2  (bases 1 to 10036)
  AUTHORS   Han,N. and Liu,X.
  TITLE     AZF microdeletion affects semen parameters, sex hormone levels, and
            chromosome karyotypes in infertile men in Xinjiang
  JOURNAL   Cell Mol Biol (Noisy-le-grand) 69 (13), 106-111 (2023)
   PUBMED   38158680
  REMARK    GeneRIF: AZF microdeletion affects semen parameters, sex hormone
            levels, and chromosome karyotypes in infertile men in Xinjiang.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 10036)
  AUTHORS   Gao,H., Wang,L., Song,Y., Ma,D., Nie,R., Hu,Y., He,H., Zhang,R.,
            Wang,S. and Guo,H.
  TITLE     [Analysis of copy number variation in AZF region of Y chromosome in
            patients with spermatogenic failure]
  JOURNAL   Zhonghua Yi Xue Yi Chuan Xue Za Zhi 40 (9), 1068-1074 (2023)
   PUBMED   37643951
  REMARK    GeneRIF: [Analysis of copy number variation in AZF region of Y
            chromosome in patients with spermatogenic failure].
REFERENCE   4  (bases 1 to 10036)
  AUTHORS   Hajiesmaeil,M., Ravasini,F., Risi,F., Magnarini,G., Olivieri,A.,
            D'Atanasio,E., Galehdari,H., Trombetta,B. and Cruciani,F.
  TITLE     High incidence of AZF duplications in clan-structured Iranian
            populations detected through Y chromosome sequencing read depth
            analysis
  JOURNAL   Sci Rep 13 (1), 11857 (2023)
   PUBMED   37481605
  REMARK    GeneRIF: High incidence of AZF duplications in clan-structured
            Iranian populations detected through Y chromosome sequencing read
            depth analysis.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 10036)
  AUTHORS   Dicke,A.K., Pilatz,A., Wyrwoll,M.J., Punab,M., Ruckert,C.,
            Nagirnaja,L., Aston,K.I., Conrad,D.F., Di Persio,S., Neuhaus,N.,
            Fietz,D., Laan,M., Stallmeyer,B. and Tuttelmann,F.
  TITLE     DDX3Y is likely the key spermatogenic factor in the AZFa region
            that contributes to human non-obstructive azoospermia
  JOURNAL   Commun Biol 6 (1), 350 (2023)
   PUBMED   36997603
  REMARK    GeneRIF: DDX3Y is likely the key spermatogenic factor in the AZFa
            region that contributes to human non-obstructive azoospermia.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 10036)
  AUTHORS   Brown,G.M., Furlong,R.A., Sargent,C.A., Erickson,R.P.,
            Longepied,G., Mitchell,M., Jones,M.H., Hargreave,T.B., Cooke,H.J.
            and Affara,N.A.
  TITLE     Characterisation of the coding sequence and fine mapping of the
            human DFFRY gene and comparative expression analysis and mapping to
            the Sxrb interval of the mouse Y chromosome of the Dffry gene
  JOURNAL   Hum Mol Genet 7 (1), 97-107 (1998)
   PUBMED   9384609
REFERENCE   7  (bases 1 to 10036)
  AUTHORS   D'Andrea,A. and Pellman,D.
  TITLE     Deubiquitinating enzymes: a new class of biological regulators
  JOURNAL   Crit Rev Biochem Mol Biol 33 (5), 337-352 (1998)
   PUBMED   9827704
  REMARK    Review article
REFERENCE   8  (bases 1 to 10036)
  AUTHORS   Lahn,B.T. and Page,D.C.
  TITLE     Functional coherence of the human Y chromosome
  JOURNAL   Science 278 (5338), 675-680 (1997)
   PUBMED   9381176
REFERENCE   9  (bases 1 to 10036)
  AUTHORS   Jones,M.H., Furlong,R.A., Burkin,H., Chalmers,I.J., Brown,G.M.,
            Khwaja,O. and Affara,N.A.
  TITLE     The Drosophila developmental gene fat facets has a human homologue
            in Xp11.4 which escapes X-inactivation and has related sequences on
            Yq11.2
  JOURNAL   Hum Mol Genet 5 (11), 1695-1701 (1996)
   PUBMED   8922996
  REMARK    Erratum:[Hum Mol Genet 1997 Feb;6(2):334-5]
REFERENCE   10 (bases 1 to 10036)
  AUTHORS   Fan,Y. and Silber,S.J.
  TITLE     Y Chromosome Infertility
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301513
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AF000986.2, Y13618.1,
            BI754571.1 and CK823170.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On May 17, 2019 this sequence version replaced NM_004654.3.
            
            Summary: This gene is a member of the peptidase C19 family. It
            encodes a protein that is similar to ubiquitin-specific proteases,
            which cleave the ubiquitin moiety from ubiquitin-fused precursors
            and ubiquitinylated proteins. [provided by RefSeq, Mar 2009].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF000986.2, SRR14038192.3899797.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1966682, SAMEA1968832
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000338981.7/ ENSP00000342812.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1790              AF000986.2         1-1790
            1791-3570           Y13618.1           903-2682
            3571-7200           AF000986.2         3571-7200
            7201-7259           Y13618.1           6313-6371
            7260-9367           AF000986.2         7260-9367
            9368-9535           BI754571.1         489-656
            9536-10036          CK823170.1         13-513              c
FEATURES             Location/Qualifiers
     source          1..10036
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="Y"
                     /map="Yq11.221"
     gene            1..10036
                     /gene="USP9Y"
                     /gene_synonym="DFFRY; FAF-Y; SPGFY2"
                     /note="ubiquitin specific peptidase 9 Y-linked"
                     /db_xref="GeneID:8287"
                     /db_xref="HGNC:HGNC:12633"
                     /db_xref="MIM:400005"
     exon            1..825
                     /gene="USP9Y"
                     /gene_synonym="DFFRY; FAF-Y; SPGFY2"
                     /inference="alignment:Splign:2.1.0"
     exon            826..885
                     /gene="USP9Y"
                     /gene_synonym="DFFRY; FAF-Y; SPGFY2"
                     /inference="alignment:Splign:2.1.0"
     exon            886..1041
                     /gene="USP9Y"
                     /gene_synonym="DFFRY; FAF-Y; SPGFY2"
                     /inference="alignment:Splign:2.1.0"
     CDS             946..8613
                     /gene="USP9Y"
                     /gene_synonym="DFFRY; FAF-Y; SPGFY2"
                     /EC_number="3.4.19.12"
                     /note="ubiquitin specific peptidase 9, Y-linked (fat
                     facets-like, Drosophila); ubiquitin thiolesterase FAF-Y;
                     ubiquitin-specific processing protease FAF-Y;
                     deubiquitinating enzyme FAF-Y; probable ubiquitin
                     carboxyl-terminal hydrolase FAF-Y; ubiquitin thioesterase
                     FAF-Y; fat facets protein-related, Y-linked;
                     ubiquitin-specific protease 9, Y chromosome; azoospermia
                     factor A"
                     /codon_start=1
                     /product="ubiquitin carboxyl-terminal hydrolase 9Y"
                     /protein_id="NP_004645.2"
                     /db_xref="CCDS:CCDS14781.1"
                     /db_xref="GeneID:8287"
                     /db_xref="HGNC:HGNC:12633"
                     /db_xref="MIM:400005"
                     /translation="MTAITHGSPVGGNDSQGQVLDGQSQHLFQQNQTSSPDSSNENSV
                     ATPPPEEQGQGDAPPQHEDEEPAFPHTELANLDDMINRPRWVVPVLPKGELEVLLEAA
                     IDLSVKGLDVKSEACQRFFRDGLTISFTKILMDEAVSGWKFEIHRCIINNTHRLVELC
                     VAKLSQDWFPLLELLAMALNPHCKFHIYNGTRPCELISSNAQLPEDELFARSSDPRSP
                     KGWLVDLINKFGTLNGFQILHDRFFNGSALNIQIIAALIKPFGQCYEFLSQHTLKKYF
                     IPVIEIVPHLLENLTDEELKKEAKNEAKNDALSMIIKSLKNLASRISGQDETIKNLEI
                     FRLKMILRLLQISSFNGKMNALNEINKVISSVSYYTHRHSNPEEEEWLTAERMAEWIQ
                     QNNILSIVLQDSLHQPQYVEKLEKILRFVIKEKALTLQDLDNIWAAQAGKHEAIVKNV
                     HDLLAKLAWDFSPGQLDHLFDCFKASWTNASKKQREKLLELIRRLAEDDKDGVMAHKV
                     LNLLWNLAQSDDVPVDIMDLALSAHIKILDYSCSQDRDAQKIQWIDHFIEELRTNDKW
                     VIPALKQIREICSLFGEASQNLSQTQRSPHIFYRHDLINQLQQNHALVTLVAENLATY
                     MNSIRLYAGDHEDYDPQTVRLGSRYSHVQEVQERLNFLRFLLKDGQLWLCAPQAKQIW
                     KCLAENAVYLCDREACFKWYSKLMGDEPDLDPDINKDFFESNVLQLDPSLLTENGMKC
                     FERFFKAVNCRERKLIAKRRSYMMDDLELIGLDYLWRVVIQSSDEIANRAIDLLKEIY
                     TNLGPRLKANQVVIHEDFIQSCFDRLKASYDTLCVFDGDKNSINCARQEAIRMVRVLT
                     VIKEYINECDSDYHKERMILPMSRAFRGKHLSLIVRFPNQGRQVDELDIWSHTNDTIG
                     SVRRCIVNRIKANVAHKKIELFVGGELIDSEDDRKLIGQLNLKDKSLITAKLTQINFN
                     MPSSPDSSSDSSTASPGNHRNHYNDGPNLEVESCLPGVIMSVHPRYISFLWQVADLGS
                     NLNMPPLRDGARVLMKLMPPDRTAVEKLRAVCLDHAKLGEGKLSPPLDSLFFGPSASQ
                     VLYLTEVVYALLMPAGVPLTDGSSDFQVHFLKSGGLPLVLSMLIRNNFLPNTDMETRR
                     GAYLNALKIAKLLLTAIGYGHVRAVAEACQPVVDGTDPITQINQVTHDQAVVLQSALQ
                     SIPNPSSECVLRNESILLAQEISNEASRYMPDICVIRAIQKIIWASACGALGLVFSPN
                     EEITKIYQMTTNGSNKLEVEDEQVCCEALEVMTLCFALLPTALDALSKEKAWQTFIID
                     LLLHCPSKTVRQLAQEQFFLMCTRCCMGHRPLLFFITLLFTILGSTAREKGKYSGDYF
                     TLLRHLLNYAYNGNINIPNAEVLLVSEIDWLKRIRDNVKNTGETGVEEPILEGHLGVT
                     KELLAFQTSEKKYHFGCEKGGANLIKELIDDFIFPASKVYLQYLRSGELPAEQAIPVC
                     SSPVTINAGFELLVALAIGCVRNLKQIVDCLTEMYYMGTAITTCEALTEWEYLPPVGP
                     RPPKGFVGLKNAGATCYMNSVIQQLYMIPSIRNSILAIEGTGSDLHDDMFGDEKQDSE
                     SNVDPRDDVFGYPHQFEDKPALSKTEDRKEYNIGVLRHLQVIFGHLAASQLQYYVPRG
                     FWKQFRLWGEPVNLREQHDALEFFNSLVDSLDEALKALGHPAILSKVLGGSFADQKIC
                     QGCPHRYECEESFTTLNVDIRNHQNLLDSLEQYIKGDLLEGANAYHCEKCDKKVDTVK
                     RLLIKKLPRVLAIQLKRFDYDWERECAIKFNDYFEFPRELDMGPYTVAGVANLERDNV
                     NSENELIEQKEQSDNETAGGTKYRLVGVLVHSGQASGGHYYSYIIQRNGKDDQTDHWY
                     KFDDGDVTECKMDDDEEMKNQCFGGEYMGEVFDHMMKRMSYRRQKRWWNAYILFYEQM
                     DMIDEDDEMIRYISELTIARPHQIIMSPAIERSVRKQNVKFMHNRLQYSLEYFQFVKK
                     LLTCNGVYLNPAPGQDYLLPEAEEITMISIQLAARFLFTTGFHTKKIVRGPASDWYDA
                     LCVLLRHSKNVRFWFTHNVLFNVSNRFSEYLLECPSAEVRGAFAKLIVFIAHFSLQDG
                     SCPSPFASPGPSSQACDNLSLSDHLLRATLNLLRREVSEHGHHLQQYFNLFVMYANLG
                     VAEKTQLLKLNVPATFMLVSLDEGPGPPIKYQYAELGKLYSVVSQLIRCCNVSSTMQS
                     SINGNPPLPNPFGDLNLSQPIMPIQQNVLDILFVRTSYVKKIIEDCSNSEDTIKLLRF
                     CSWENPQFSSTVLSELLWQVAYSYTYELRPYLDLLFQILLIEDSWQTHRIHNALKGIP
                     DDRDGLFDTIQRSKNHYQKRAYQCIKCMVALFSSCPVAYQILQGNGDLKRKWTWAVEW
                     LGDELERRPYTGNPQYSYNNWSPPVQSNETANGYFLERSHSARMTLAKACELCPEEEP
                     DDQDAPDEHEPSPSEDAPLYPHSPASQYQQNNHVHGQPYTGPAAHHLNNPQKTGQRTQ
                     ENYEGNEEVSSPQMKDQ"
     exon            1042..1190
                     /gene="USP9Y"
                     /gene_synonym="DFFRY; FAF-Y; SPGFY2"
                     /inference="alignment:Splign:2.1.0"
     exon            1191..1270
                     /gene="USP9Y"
                     /gene_synonym="DFFRY; FAF-Y; SPGFY2"
                     /inference="alignment:Splign:2.1.0"
     exon            1271..1383
                     /gene="USP9Y"
                     /gene_synonym="DFFRY; FAF-Y; SPGFY2"
                     /inference="alignment:Splign:2.1.0"
     exon            1384..1602
                     /gene="USP9Y"
                     /gene_synonym="DFFRY; FAF-Y; SPGFY2"
                     /inference="alignment:Splign:2.1.0"
     exon            1603..1718
                     /gene="USP9Y"
                     /gene_synonym="DFFRY; FAF-Y; SPGFY2"
                     /inference="alignment:Splign:2.1.0"
     exon            1719..1970
                     /gene="USP9Y"
                     /gene_synonym="DFFRY; FAF-Y; SPGFY2"
                     /inference="alignment:Splign:2.1.0"
     exon            1971..2109
                     /gene="USP9Y"
                     /gene_synonym="DFFRY; FAF-Y; SPGFY2"
                     /inference="alignment:Splign:2.1.0"
     exon            2110..2262
                     /gene="USP9Y"
                     /gene_synonym="DFFRY; FAF-Y; SPGFY2"
                     /inference="alignment:Splign:2.1.0"
     exon            2263..2367
                     /gene="USP9Y"
                     /gene_synonym="DFFRY; FAF-Y; SPGFY2"
                     /inference="alignment:Splign:2.1.0"
     exon            2368..2574
                     /gene="USP9Y"
                     /gene_synonym="DFFRY; FAF-Y; SPGFY2"
                     /inference="alignment:Splign:2.1.0"
     exon            2575..2711
                     /gene="USP9Y"
                     /gene_synonym="DFFRY; FAF-Y; SPGFY2"
                     /inference="alignment:Splign:2.1.0"
     exon            2712..2845
                     /gene="USP9Y"
                     /gene_synonym="DFFRY; FAF-Y; SPGFY2"
                     /inference="alignment:Splign:2.1.0"
     exon            2846..2933
                     /gene="USP9Y"
                     /gene_synonym="DFFRY; FAF-Y; SPGFY2"
                     /inference="alignment:Splign:2.1.0"
     exon            2934..3276
                     /gene="USP9Y"
                     /gene_synonym="DFFRY; FAF-Y; SPGFY2"
                     /inference="alignment:Splign:2.1.0"
     exon            3277..3372
                     /gene="USP9Y"
                     /gene_synonym="DFFRY; FAF-Y; SPGFY2"
                     /inference="alignment:Splign:2.1.0"
     exon            3373..3584
                     /gene="USP9Y"
                     /gene_synonym="DFFRY; FAF-Y; SPGFY2"
                     /inference="alignment:Splign:2.1.0"
     exon            3585..3825
                     /gene="USP9Y"
                     /gene_synonym="DFFRY; FAF-Y; SPGFY2"
                     /inference="alignment:Splign:2.1.0"
     exon            3826..3975
                     /gene="USP9Y"
                     /gene_synonym="DFFRY; FAF-Y; SPGFY2"
                     /inference="alignment:Splign:2.1.0"
     exon            3976..4096
                     /gene="USP9Y"
                     /gene_synonym="DFFRY; FAF-Y; SPGFY2"
                     /inference="alignment:Splign:2.1.0"
     exon            4097..4227
                     /gene="USP9Y"
                     /gene_synonym="DFFRY; FAF-Y; SPGFY2"
                     /inference="alignment:Splign:2.1.0"
     exon            4228..4506
                     /gene="USP9Y"
                     /gene_synonym="DFFRY; FAF-Y; SPGFY2"
                     /inference="alignment:Splign:2.1.0"
     exon            4507..4632
                     /gene="USP9Y"
                     /gene_synonym="DFFRY; FAF-Y; SPGFY2"
                     /inference="alignment:Splign:2.1.0"
     exon            4633..4758
                     /gene="USP9Y"
                     /gene_synonym="DFFRY; FAF-Y; SPGFY2"
                     /inference="alignment:Splign:2.1.0"
     exon            4759..4928
                     /gene="USP9Y"
                     /gene_synonym="DFFRY; FAF-Y; SPGFY2"
                     /inference="alignment:Splign:2.1.0"
     exon            4929..5037
                     /gene="USP9Y"
                     /gene_synonym="DFFRY; FAF-Y; SPGFY2"
                     /inference="alignment:Splign:2.1.0"
     exon            5038..5184
                     /gene="USP9Y"
                     /gene_synonym="DFFRY; FAF-Y; SPGFY2"
                     /inference="alignment:Splign:2.1.0"
     exon            5185..5331
                     /gene="USP9Y"
                     /gene_synonym="DFFRY; FAF-Y; SPGFY2"
                     /inference="alignment:Splign:2.1.0"
     exon            5332..5554
                     /gene="USP9Y"
                     /gene_synonym="DFFRY; FAF-Y; SPGFY2"
                     /inference="alignment:Splign:2.1.0"
     exon            5555..5775
                     /gene="USP9Y"
                     /gene_synonym="DFFRY; FAF-Y; SPGFY2"
                     /inference="alignment:Splign:2.1.0"
     exon            5776..5966
                     /gene="USP9Y"
                     /gene_synonym="DFFRY; FAF-Y; SPGFY2"
                     /inference="alignment:Splign:2.1.0"
     exon            5967..6140
                     /gene="USP9Y"
                     /gene_synonym="DFFRY; FAF-Y; SPGFY2"
                     /inference="alignment:Splign:2.1.0"
     exon            6141..6282
                     /gene="USP9Y"
                     /gene_synonym="DFFRY; FAF-Y; SPGFY2"
                     /inference="alignment:Splign:2.1.0"
     exon            6283..7033
                     /gene="USP9Y"
                     /gene_synonym="DFFRY; FAF-Y; SPGFY2"
                     /inference="alignment:Splign:2.1.0"
     exon            7034..7157
                     /gene="USP9Y"
                     /gene_synonym="DFFRY; FAF-Y; SPGFY2"
                     /inference="alignment:Splign:2.1.0"
     exon            7158..7383
                     /gene="USP9Y"
                     /gene_synonym="DFFRY; FAF-Y; SPGFY2"
                     /inference="alignment:Splign:2.1.0"
     exon            7384..7513
                     /gene="USP9Y"
                     /gene_synonym="DFFRY; FAF-Y; SPGFY2"
                     /inference="alignment:Splign:2.1.0"
     exon            7514..7699
                     /gene="USP9Y"
                     /gene_synonym="DFFRY; FAF-Y; SPGFY2"
                     /inference="alignment:Splign:2.1.0"
     exon            7700..7920
                     /gene="USP9Y"
                     /gene_synonym="DFFRY; FAF-Y; SPGFY2"
                     /inference="alignment:Splign:2.1.0"
     exon            7921..8009
                     /gene="USP9Y"
                     /gene_synonym="DFFRY; FAF-Y; SPGFY2"
                     /inference="alignment:Splign:2.1.0"
     exon            8010..8166
                     /gene="USP9Y"
                     /gene_synonym="DFFRY; FAF-Y; SPGFY2"
                     /inference="alignment:Splign:2.1.0"
     exon            8167..8379
                     /gene="USP9Y"
                     /gene_synonym="DFFRY; FAF-Y; SPGFY2"
                     /inference="alignment:Splign:2.1.0"
     exon            8380..8475
                     /gene="USP9Y"
                     /gene_synonym="DFFRY; FAF-Y; SPGFY2"
                     /inference="alignment:Splign:2.1.0"
     exon            8476..10036
                     /gene="USP9Y"
                     /gene_synonym="DFFRY; FAF-Y; SPGFY2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      10020..10025
                     /regulatory_class="polyA_signal_sequence"
                     /gene="USP9Y"
                     /gene_synonym="DFFRY; FAF-Y; SPGFY2"
                     /note="hexamer: AATAAA"
     polyA_site      10036
                     /gene="USP9Y"
                     /gene_synonym="DFFRY; FAF-Y; SPGFY2"
                     /note="major polyA site"
ORIGIN      
        1 tgaataattg aactttgttt atttctccat atttttgcag tggtaattcc attataaaac
       61 ctaatgaaac aatgttttta tagatggtgt ggaaagactt ttctgggctc agaggtgaaa
      121 ctgacccttg tgtatcagca gcatttctga ctgactgaga gagtgtagtg attaacagag
      181 ttgtgatgtt agttaagaaa cttagatttg ccattgtagc ttttctacca attagcagat
      241 tgtttaactc actgaaattg taaagtggta gacgtggact tagtcattac tgggcagctt
      301 atgaattgta ttcatttact catgatgtaa aaatggttag tctccacttt taaggctcta
      361 gttctagtgg ctaaataggt acttatttat acagtatgat aactgctgta ttaaaataca
      421 tgtctcaaat gtggaatagt agaagaggtg aagaaaatca tagtttgagg tagaatactg
      481 tttgctggtc ttaaaaactg tggtattttg gtgattccat aaattaggtc agatacttcc
      541 actggaggga aacagtttaa aggatatatg tgatactatt aatagaatga ggaagacaca
      601 ccagatattt aggagggaat tagcgagctt gaaactaaga gctggtttga atgagactgg
      661 gtcataagtg atttcaagta ccagattaag gcactgagat tttattttta agcactgaag
      721 tcagattttt tccttttaaa agaaaggatt catgatgaaa tctgcttttt gttttgcaga
      781 gagcttggag ataattctgg tggctgtgtg gagtatgtgt tggaggtatt aaattttcac
      841 agtatatata aggcagcaat tgataggcct ttcacagatt cttctgataa ctacataaag
      901 agacaaaaaa aagaaaaaag agcaaagatc tgtgctgtgt caagtatgac agccatcact
      961 catggctctc cagtaggagg gaacgacagc cagggccagg ttcttgatgg ccagtctcag
     1021 catctcttcc aacagaacca gacttcatca cctgattctt ccaatgagaa ttccgtagca
     1081 actcctcctc cagaggaaca agggcaaggt gatgccccac cacagcatga agatgaagag
     1141 cctgcatttc cacatactga gctggcaaac ctggatgaca tgatcaacag gcctcgatgg
     1201 gtggttcctg ttttgccaaa aggggaatta gaagtgcttt tagaagctgc tattgatctt
     1261 agtgtaaaag gccttgatgt taaaagtgaa gcatgccaac gtttttttcg agatggacta
     1321 acaatatctt tcactaaaat tcttatggat gaggctgtga gtggctggaa gtttgaaatt
     1381 catagatgta ttattaacaa tactcatcgc ctagtggagc tttgtgtggc caagttgtcc
     1441 caagattggt ttccacttct agaacttctc gccatggcct taaatcctca ctgcaagttt
     1501 catatctaca atggtacacg tccgtgtgaa ttaatttcct caaatgctca gttgcctgaa
     1561 gatgaattat ttgctcgttc ttcagatcct cgatcaccaa aaggttggct agtggatctc
     1621 atcaataaat ttggcacatt aaatgggttc cagattttgc atgatcgttt ttttaatgga
     1681 tcagcattaa atattcaaat aattgcagct cttattaaac catttggaca atgctatgag
     1741 tttctcagtc aacatacact gaaaaagtac ttcattccag ttatagaaat agttccacat
     1801 ttattggaaa acttaactga tgaagaactg aaaaaggagg caaagaatga agccaaaaat
     1861 gatgcccttt caatgattat taaatctttg aagaacttag cttcaagaat ttcaggacaa
     1921 gatgagacta taaaaaattt ggaaattttt aggttaaaga tgatactcag attgttgcaa
     1981 atttcctctt ttaatggaaa gatgaatgca ctgaatgaaa taaataaggt tatatctagt
     2041 gtatcatatt atactcatcg gcatagtaat cctgaggagg aagaatggct gacagctgag
     2101 cgaatggcag aatggataca gcaaaataat atcttatcca tagtcttgca agacagtctt
     2161 catcaaccac aatatgtaga aaagctagag aaaattcttc gttttgtgat taaagaaaag
     2221 gctcttacat tacaggacct tgataatatc tgggcagcac aggcaggaaa acatgaagcc
     2281 attgtgaaga atgtacatga tctgctagca aagttggctt gggatttttc tcctggacaa
     2341 cttgatcatc tttttgattg ctttaaggca agttggacaa atgcaagtaa aaagcaacgt
     2401 gaaaagctcc ttgagttgat acgccgtctt gcagaagatg ataaagatgg tgtgatggca
     2461 cacaaagtgt tgaaccttct ttggaacctg gctcagagtg atgatgtgcc tgtagacatc
     2521 atggaccttg ctcttagtgc ccacataaaa atactagatt atagttgttc ccaggatcga
     2581 gatgcacaga agatccagtg gatagatcac tttatagaag aacttcgcac aaatgacaag
     2641 tgggtaattc ctgctctgaa acaaataaga gaaatttgta gtttgtttgg tgaagcatct
     2701 caaaatttga gtcaaactca gcgaagtccc cacatatttt atcgccatga tttaatcaac
     2761 cagcttcaac aaaatcatgc tttagttact ttggtagcag aaaaccttgc aacctacatg
     2821 aatagcatca gattgtatgc tggagatcat gaagactatg atccacaaac agtgaggctt
     2881 ggaagtcgat acagtcatgt tcaagaagtt caagaacgac taaacttcct tagattttta
     2941 ctgaaggatg gccaactgtg gctctgtgct cctcaggcaa aacaaatatg gaagtgctta
     3001 gcagaaaatg cagtttatct ttgtgatcgt gaagcctgtt ttaagtggta ttccaagtta
     3061 atgggggatg aaccagactt ggatcctgat attaataagg acttctttga aagtaatgta
     3121 cttcagcttg atccttccct tttaactgaa aatggaatga aatgctttga aagatttttc
     3181 aaagctgtca attgtcgaga aaggaaacta atagcaaaaa gaagatccta tatgatggat
     3241 gatttggaat taattggact agactacctt tggagggttg tgattcagag tagtgacgag
     3301 attgctaaca gagctataga tcttcttaaa gagatataca caaaccttgg cccaagatta
     3361 aaagccaatc aggtggttat ccatgaagac ttcattcagt cttgctttga tcgtttaaaa
     3421 gcatcatatg atacactgtg tgtttttgat ggtgacaaaa acagcattaa ttgtgcaaga
     3481 caagaagcca ttcgaatggt tagagtatta actgttataa aagagtacat taatgaatgt
     3541 gacagtgatt atcacaagga aagaatgatt ctacctatgt cgagagcatt tcgtggcaaa
     3601 cacctctctc ttatagttcg gtttccaaac cagggcagac aggttgatga gttggatata
     3661 tggtctcata cgaatgacac aattggttca gtacggcgat gtattgttaa tcgtattaaa
     3721 gccaatgtag cccacaaaaa aattgaactt tttgtgggtg gtgagctgat agattctgaa
     3781 gatgacagaa agctaattgg acaattaaac ttaaaagata aatctctaat tacagccaaa
     3841 cttacacaaa taaatttcaa tatgccatca agtcctgata gctcttccga ttcctcaact
     3901 gcatctcctg gaaaccaccg taatcattac aatgatggtc ccaatctaga ggtggaaagt
     3961 tgtttgcctg gggtgataat gtcagtgcat cccagataca tctctttcct ttggcaagtt
     4021 gcagacttag gtagcaacct gaatatgcca cctcttagag atggagcaag agtacttatg
     4081 aaacttatgc caccagatag aacagctgta gaaaaattac gagctgtttg tttggaccat
     4141 gcaaaacttg gagaaggcaa acttagtcca ccccttgact ctcttttctt tggtccttct
     4201 gcctcccaag ttctatacct aacagaggta gtttatgcct tgttaatgcc tgctggtgtg
     4261 cctctaactg atgggtcctc tgactttcaa gttcacttct tgaaaagtgg tggcttacct
     4321 cttgtactga gtatgctaat aagaaataac ttcttgccaa atacagatat ggaaactcga
     4381 aggggtgctt atttaaatgc tcttaaaata gccaaactgt tgttaactgc gattggctat
     4441 ggccatgttc gagctgtagc agaagcttgt cagccagttg tagatggtac agaccccata
     4501 acacagatta accaagttac tcatgatcaa gcagtggtgc tacaaagtgc ccttcagagc
     4561 attcctaatc cctcatccga gtgcgtactt agaaatgagt ccatacttct tgctcaggaa
     4621 atatctaatg aggcttcaag atatatgcct gatatttgtg taattagggc tatacagaaa
     4681 attatctggg catcagcatg tggggcatta ggactagttt ttagcccaaa tgaagaaata
     4741 actaaaattt atcagatgac caccaatgga agcaataagc tggaggtgga agatgaacaa
     4801 gtttgctgtg aagcactgga agtgatgacc ttatgttttg ctttacttcc aacagcgttg
     4861 gatgcactta gtaaagaaaa agcctggcag accttcatca ttgacttatt attgcactgt
     4921 ccaagcaaaa ctgttcgtca gttggcacag gagcagttct ttttaatgtg caccagatgt
     4981 tgcatgggac acaggcctct gcttttcttc attactttac tctttaccat actggggagc
     5041 acagcaagag agaagggtaa atattcaggt gattatttca cacttttacg gcaccttctc
     5101 aattatgctt acaatggcaa tattaacata cccaatgctg aagttcttct tgtcagtgaa
     5161 attgattggc tcaaaaggat tagggataat gttaaaaaca caggtgaaac aggtgtcgaa
     5221 gagccaatac tggaaggcca ccttggggta acaaaagagt tattggcctt tcaaacttct
     5281 gagaaaaagt atcactttgg ttgtgaaaaa ggaggtgcta atctcattaa agaattaatt
     5341 gatgatttca tctttcccgc atccaaagtt tacctgcagt atttaagaag tggagaacta
     5401 ccagctgagc aggctattcc agtctgtagt tcacccgtta ccatcaatgc cggttttgag
     5461 ctacttgtag cattagctat tggctgtgtg aggaatctca aacagatagt agactgtttg
     5521 actgaaatgt attacatggg cacagcaatt actacttgtg aagcacttac tgagtgggaa
     5581 tatctgcccc ctgttggacc ccgcccacca aaaggatttg tgggactcaa aaatgctggt
     5641 gctacgtgtt acatgaactc tgtgatccag cagctataca tgattccttc tatcaggaac
     5701 agtattcttg caattgaagg cacaggtagt gatttacacg atgatatgtt cggggatgag
     5761 aagcaggaca gtgagagtaa tgttgatccc cgagatgatg tatttggata tcctcatcaa
     5821 tttgaagaca agccagcatt aagtaagaca gaagatagga aagagtataa tattggtgtc
     5881 ctaagacacc ttcaggtcat ctttggtcat ttagctgctt cccaactaca atactatgta
     5941 cccagaggat tttggaaaca gttcaggctt tggggtgaac ctgttaatct ccgtgaacaa
     6001 catgatgcct tagagttttt taattctttg gtggatagtt tagatgaagc tttaaaagct
     6061 ttaggacacc cggctatact aagtaaagtc ctaggaggct cctttgctga tcagaagatc
     6121 tgccaaggct gcccacatag gtatgaatgt gaagaatctt ttacaacttt gaatgtggat
     6181 attagaaatc atcaaaatct tcttgactct ttggaacagt atatcaaagg agatttattg
     6241 gaaggtgcaa atgcatatca ttgtgaaaaa tgtgataaaa aggttgacac agtaaagcgc
     6301 ctgctaatta aaaaattgcc tcgggttctt gctatccaac tcaaacgatt tgactatgac
     6361 tgggaaagag aatgtgcaat taaattcaat gattattttg aatttcctcg agagctggat
     6421 atgggacctt acacagtagc aggtgttgca aacctggaaa gggataatgt aaactcagaa
     6481 aatgagttga ttgaacagaa agagcagtct gacaatgaaa ctgcaggagg cacaaagtac
     6541 agacttgtag gagtgcttgt acacagtggt caagcaagcg gtgggcatta ttattcttac
     6601 atcattcaaa ggaatggtaa agatgatcag acagatcact ggtataaatt tgatgatgga
     6661 gatgtaacag aatgcaaaat ggatgatgat gaagaaatga aaaatcagtg ttttggtgga
     6721 gagtacatgg gagaagtatt tgatcacatg atgaagcgca tgtcatatag gcgacagaag
     6781 aggtggtgga atgcttacat acttttttat gaacaaatgg atatgataga tgaagatgat
     6841 gagatgataa gatacatatc agagctaact attgcaagac cccatcagat cattatgtca
     6901 ccagccattg agagaagtgt acggaaacaa aatgtgaaat ttatgcataa ccgattgcaa
     6961 tatagtttag agtattttca gtttgtgaaa aaactgctta catgtaatgg tgtttattta
     7021 aaccctgctc cagggcagga ttatttgttg cctgaagcag aagaaattac tatgattagt
     7081 attcagcttg ctgctagatt cctctttacc actggatttc acaccaagaa aatagttcgt
     7141 ggtcctgcca gtgactggta tgatgcactg tgcgttcttc tccgtcacag caaaaatgta
     7201 cgtttttggt ttactcataa tgtccttttt aatgtatcaa atcgcttctc tgaatacctt
     7261 ctggagtgcc ctagtgcaga agtgaggggt gcatttgcaa aacttatagt gtttattgca
     7321 cacttttcct tgcaagatgg gtcttgtcct tctccttttg catctccagg accttctagt
     7381 caggcatgtg ataacttgag cttgagtgac cacttactaa gagccacact aaatctcttg
     7441 agaagggaag tttcagagca tggacatcat ttacagcaat attttaattt gtttgtaatg
     7501 tatgccaatt taggtgtggc agaaaaaaca cagcttctga aattgaatgt acctgctacc
     7561 tttatgcttg tgtctttaga cgaaggacca ggtcctccaa tcaaatatca gtatgctgaa
     7621 ttaggcaagt tatattcagt agtgtctcag ctgattcgtt gttgcaatgt gtcatcaaca
     7681 atgcagtctt caatcaatgg taatccccct ctccccaatc ctttcggtga ccttaattta
     7741 tcacagccta taatgccaat tcagcagaat gtgttagaca ttttatttgt gagaacaagt
     7801 tatgtgaaga aaattattga agactgcagt aactcagagg ataccatcaa attacttcgc
     7861 ttttgctctt gggagaatcc tcagttctca tctactgtcc tcagcgaact tctctggcag
     7921 gttgcatatt catataccta tgaacttcgg ccatatttag atctactttt ccaaatttta
     7981 ctgattgagg actcctggca gactcacaga attcataatg cacttaaagg aattccagat
     8041 gacagagatg ggctgttcga tacaatacag cgctcgaaga atcactatca aaaacgagca
     8101 tatcagtgca taaaatgtat ggtagctcta tttagcagtt gtcctgttgc ttaccagatc
     8161 ttacagggta acggagatct taaaagaaaa tggacctggg cagtggaatg gctaggagat
     8221 gaacttgaaa gaagaccata tactggcaat cctcagtata gttacaacaa ttggtctcct
     8281 ccagtacaaa gcaatgaaac agcaaatggt tatttcttag aaagatcaca tagtgctagg
     8341 atgacacttg caaaagcttg tgaactctgt ccagaagagg agccagatga ccaggatgcc
     8401 ccagatgagc atgagccctc tccatcagaa gatgccccat tatatcctca ttcacctgcc
     8461 tctcagtatc aacagaataa tcatgtacat ggacagccat atacaggacc agcagcacat
     8521 cacttgaaca accctcagaa aacaggccaa cgaacacaag aaaattatga aggcaatgaa
     8581 gaagtatcct cacctcagat gaaggatcag tgaaaagcaa taattaactg cttcctttat
     8641 gactatgcac taaggtctta tagtccaaac tttctctgtg tctggctagt attgaaaact
     8701 agataaactg ctccaaacca acatggagta aagagcatat tcactggttt atttgcagta
     8761 atttgcaatt tgtcagtgta taagacacat gcagggtgaa gtgtacagag ttttgtaaca
     8821 aatgactggt cctaatctgt aaatgagaaa ggtatatata ctatgttaat gtctgactgt
     8881 taattcttaa gcaagaaact ttttttgatg aaaacaagtc agatctacac agtcacacaa
     8941 ttattttttg ttgtgttcac tacattgtgc aattgatatt gcctgctttg agcagtttgg
     9001 tcaacttacc aacttccccc caaaaaaggg aacataaaag agcccatctt tgtcagttta
     9061 caccaatagt ttcttgttaa tccttctttc ctggatatat aaggctggtg gtaacttttg
     9121 aattatatgg ttgatgtgga aaattggcag tgtaacattt ctagatactt ttcattacct
     9181 ttttattctg gtatataggc taaccacttt aaagctattc ttatgctgta acagttagca
     9241 tggcttcaca ctgtttgtgt agccaagagg acagaattac atgaatgaca gtgcccagag
     9301 tgacagctgt atattgctca gagcttttat ttcttatacc tagaataaat ataaaatggg
     9361 ggaaaaatgt gacagacaag cagtttttca ttgcacacat attcttcaca tttaatgttt
     9421 gatagttcaa tttcttgagc tgaagaatat caaagtatcg ataatacgaa ttttaaaata
     9481 ttaaaaccaa tacacaaaat tttcctatgt cagaatgtgg tggagcataa tagattgtat
     9541 ttggtgtgct tgcgattttt tttttccata gaatttatta agtgaagttt ctaaaacttt
     9601 gcttctcctg atcccggtga agtgtacatc ataagaatcc atagtacttt gaagtaccat
     9661 tgcaccaaga tgtctgactg aattcatagt cacactttta tttgaaagaa agaattgttg
     9721 tagttttttt tcattattct aaaactcttg ttgttagata caagatttaa ttaagatcta
     9781 agctcctgct tatttaatgt aattctaagg taccatttta gaaaaaacat ttgttttaag
     9841 attccaagaa acctgtgagt taatactata tttaaaagag aattggtaaa ttttgaatgt
     9901 gtgtaatatt ttggaacctg tttaaaaacc aaatatacct gcaaatagat acagcctatc
     9961 ctatactatt taaatgtttg gctgttttgt tttatagaaa ttattttgct gaattcacaa
    10021 ataaaattta agaaga
//
