LOCUS       NM_005154              18865 bp    mRNA    linear   PRI 12-NOV-2024
DEFINITION  Homo sapiens ubiquitin specific peptidase 8 (USP8), transcript
            variant 1, mRNA.
ACCESSION   NM_005154
VERSION     NM_005154.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 18865)
  AUTHORS   Caba,C., Black,M., Liu,Y., DaDalt,A.A., Mallare,J., Fan,L.,
            Harding,R.J., Wang,Y.X., Vacratsis,P.O., Huang,R., Zhuang,Z. and
            Tong,Y.
  TITLE     Autoinhibition of ubiquitin-specific protease 8: Insights into
            domain interactions and mechanisms of regulation
  JOURNAL   J Biol Chem 300 (10), 107727 (2024)
   PUBMED   39214302
  REMARK    GeneRIF: Autoinhibition of ubiquitin-specific protease 8: Insights
            into domain interactions and mechanisms of regulation.
REFERENCE   2  (bases 1 to 18865)
  AUTHORS   Miao,H., Wang,L., Gong,F., Duan,L., Wang,L., Yao,Y., Feng,M.,
            Deng,K., Wang,R., Xiao,Y., Ling,Q., Zhu,H. and Lu,L.
  TITLE     A long-term prognosis study of human USP8-mutated ACTH-secreting
            pituitary neuroendocrine tumours
  JOURNAL   Clin Endocrinol (Oxf) 101 (1), 32-41 (2024)
   PUBMED   38691659
  REMARK    GeneRIF: A long-term prognosis study of human USP8-mutated
            ACTH-secreting pituitary neuroendocrine tumours.
REFERENCE   3  (bases 1 to 18865)
  AUTHORS   Endo,A., Fukushima,T., Takahashi,C., Tsuchiya,H., Ohtake,F.,
            Ono,S., Ly,T., Yoshida,Y., Tanaka,K., Saeki,Y. and Komada,M.
  TITLE     USP8 prevents aberrant NF-kappaB and Nrf2 activation by
            counteracting ubiquitin signals from endosomes
  JOURNAL   J Cell Biol 223 (3) (2024)
   PUBMED   38180476
  REMARK    GeneRIF: USP8 prevents aberrant NF-kappaB and Nrf2 activation by
            counteracting ubiquitin signals from endosomes.
REFERENCE   4  (bases 1 to 18865)
  AUTHORS   Xia,R., Jia,H., Fan,J., Liu,Y. and Jia,J.
  TITLE     USP8 promotes smoothened signaling by preventing its ubiquitination
            and changing its subcellular localization
  JOURNAL   PLoS Biol 10 (1), e1001238 (2012)
   PUBMED   22253573
  REMARK    GeneRIF: USP8 is a positive regulator in Hh signaling by
            down-regulating Smo ubiquitination and thereby mediating Smo
            intracellular trafficking.
REFERENCE   5  (bases 1 to 18865)
  AUTHORS   Wright,M.H., Berlin,I. and Nash,P.D.
  TITLE     Regulation of endocytic sorting by ESCRT-DUB-mediated
            deubiquitination
  JOURNAL   Cell Biochem Biophys 60 (1-2), 39-46 (2011)
   PUBMED   21448666
  REMARK    GeneRIF: Studies indicate that USP8/Ubpy and AMSH interact with
            ESCRT components to modulate the ubiquitination status of receptors
            and relevant sorting proteins.
            Review article
REFERENCE   6  (bases 1 to 18865)
  AUTHORS   Berlin,I., Higginbotham,K.M., Dise,R.S., Sierra,M.I. and Nash,P.D.
  TITLE     The deubiquitinating enzyme USP8 promotes trafficking and
            degradation of the chemokine receptor 4 at the sorting endosome
  JOURNAL   J Biol Chem 285 (48), 37895-37908 (2010)
   PUBMED   20876529
  REMARK    GeneRIF: USP8 promotes trafficking and degradation of CXCR4 at the
            sorting endosome.
REFERENCE   7  (bases 1 to 18865)
  AUTHORS   Mizuno,E., Kobayashi,K., Yamamoto,A., Kitamura,N. and Komada,M.
  TITLE     A deubiquitinating enzyme UBPY regulates the level of protein
            ubiquitination on endosomes
  JOURNAL   Traffic 7 (8), 1017-1031 (2006)
   PUBMED   16771824
  REMARK    GeneRIF: UBPY regulates the level of protein ubiquitination on
            endosomes, which is required for maintaining the morphology of the
            organelle
REFERENCE   8  (bases 1 to 18865)
  AUTHORS   Naviglio,S., Mattecucci,C., Matoskova,B., Nagase,T., Nomura,N., Di
            Fiore,P.P. and Draetta,G.F.
  TITLE     UBPY: a growth-regulated human ubiquitin isopeptidase
  JOURNAL   EMBO J 17 (12), 3241-3250 (1998)
   PUBMED   9628861
REFERENCE   9  (bases 1 to 18865)
  AUTHORS   Janssen,J.W., Schleithoff,L., Bartram,C.R. and Schulz,A.S.
  TITLE     An oncogenic fusion product of the phosphatidylinositol 3-kinase
            p85beta subunit and HUMORF8, a putative deubiquitinating enzyme
  JOURNAL   Oncogene 16 (13), 1767-1772 (1998)
   PUBMED   9582025
REFERENCE   10 (bases 1 to 18865)
  AUTHORS   Hedera,P.
  TITLE     Hereditary Spastic Paraplegia Overview
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301682
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK292400.1, KF459553.1,
            AC012170.6, D29956.1, BM751645.1, AA399951.1, AA399952.1 and
            AI276208.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_005154.4.
            
            Summary: This gene encodes a protein that belongs to the
            ubiquitin-specific processing protease family of proteins. The
            encoded protein is thought to regulate the morphology of the
            endosome by ubiquitination of proteins on this organelle and is
            involved in cargo sorting and membrane trafficking at the early
            endosome stage. This protein is required for the cell to enter the
            S phase of the cell cycle and also functions as a positive
            regulator in the Hedgehog signaling pathway in development.
            Pseudogenes of this gene are present on chromosomes 2 and 6.
            Alternate splicing results in multiple transcript variants.
            [provided by RefSeq, Sep 2013].
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (a). Variants 1 and 2 encode the same protein.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803617.49321.1,
                                           SRR1803611.189746.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000307179.9/ ENSP00000302239.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1502              AK292400.1         24-1525
            1503-1674           KF459553.1         1-172               c
            1675-1773           AC012170.6         128665-128763
            1774-3207           AK292400.1         1797-3230
            3208-3208           AC012170.6         144129-144129
            3209-3567           AK292400.1         3232-3590
            3568-3807           D29956.1           3710-3949
            3808-4176           AC012170.6         146267-146635
            4177-4218           D29956.1           4318-4359
            4219-4392           BM751645.1         331-504
            4393-4667           AA399951.1         39-313
            4668-5001           AC012170.6         147127-147460
            5002-5524           AA399952.1         5-527               c
            5525-5527           AI276208.1         14-16               c
            5528-18865          AC012170.6         147987-161324
FEATURES             Location/Qualifiers
     source          1..18865
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="15"
                     /map="15q21.2"
     gene            1..18865
                     /gene="USP8"
                     /gene_synonym="HumORF8; PITA4; SPG59; UBPY"
                     /note="ubiquitin specific peptidase 8"
                     /db_xref="GeneID:9101"
                     /db_xref="HGNC:HGNC:12631"
                     /db_xref="MIM:603158"
     exon            1..110
                     /gene="USP8"
                     /gene_synonym="HumORF8; PITA4; SPG59; UBPY"
                     /inference="alignment:Splign:2.1.0"
     exon            111..279
                     /gene="USP8"
                     /gene_synonym="HumORF8; PITA4; SPG59; UBPY"
                     /inference="alignment:Splign:2.1.0"
     CDS             176..3532
                     /gene="USP8"
                     /gene_synonym="HumORF8; PITA4; SPG59; UBPY"
                     /EC_number="3.4.19.12"
                     /note="isoform a is encoded by transcript variant 1;
                     ubiquitin carboxyl-terminal hydrolase 8; ubiquitin
                     isopeptidase Y; deubiquitinating enzyme 8;
                     ubiquitin-specific-processing protease 8; ubiquitin
                     thiolesterase 8"
                     /codon_start=1
                     /product="ubiquitin carboxyl-terminal hydrolase 8 isoform
                     a"
                     /protein_id="NP_005145.3"
                     /db_xref="CCDS:CCDS10137.1"
                     /db_xref="GeneID:9101"
                     /db_xref="HGNC:HGNC:12631"
                     /db_xref="MIM:603158"
                     /translation="MPAVASVPKELYLSSSLKDLNKKTEVKPEKISTKSYVHSALKIF
                     KTAEECRLDRDEERAYVLYMKYVTVYNLIKKRPDFKQQQDYFHSILGPGNIKKAVEEA
                     ERLSESLKLRYEEAEVRKKLEEKDRQEEAQRLQQKRQETGREDGGTLAKGSLENVLDS
                     KDKTQKSNGEKNEKCETKEKGAITAKELYTMMTDKNISLIIMDARRMQDYQDSCILHS
                     LSVPEEAISPGVTASWIEAHLPDDSKDTWKKRGNVEYVVLLDWFSSAKDLQIGTTLRS
                     LKDALFKWESKTVLRNEPLVLEGGYENWLLCYPQYTTNAKVTPPPRRQNEEVSISLDF
                     TYPSLEESIPSKPAAQTPPASIEVDENIELISGQNERMGPLNISTPVEPVAASKSDVS
                     PIIQPVPSIKNVPQIDRTKKPAVKLPEEHRIKSESTNHEQQSPQSGKVIPDRSTKPVV
                     FSPTLMLTDEEKARIHAETALLMEKNKQEKELRERQQEEQKEKLRKEEQEQKAKKKQE
                     AEENEITEKQQKAKEEMEKKESEQAKKEDKETSAKRGKEITGVKRQSKSEHETSDAKK
                     SVEDRGKRCPTPEIQKKSTGDVPHTSVTGDSGSGKPFKIKGQPESGILRTGTFREDTD
                     DTERNKAQREPLTRARSEEMGRIVPGLPSGWAKFLDPITGTFRYYHSPTNTVHMYPPE
                     MAPSSAPPSTPPTHKAKPQIPAERDREPSKLKRSYSSPDITQAIQEEEKRKPTVTPTV
                     NRENKPTCYPKAEISRLSASQIRNLNPVFGGSGPALTGLRNLGNTCYMNSILQCLCNA
                     PHLADYFNRNCYQDDINRSNLLGHKGEVAEEFGIIMKALWTGQYRYISPKDFKITIGK
                     INDQFAGYSQQDSQELLLFLMDGLHEDLNKADNRKRYKEENNDHLDDFKAAEHAWQKH
                     KQLNESIIVALFQGQFKSTVQCLTCHKKSRTFEAFMYLSLPLASTSKCTLQDCLRLFS
                     KEEKLTDNNRFYCSHCRARRDSLKKIEIWKLPPVLLVHLKRFSYDGRWKQKLQTSVDF
                     PLENLDLSQYVIGPKNNLKKYNLFSVSNHYGGLDGGHYTAYCKNAARQRWFKFDDHEV
                     SDISVSSVKSSAAYILFYTSLGPRVTDVAT"
     exon            280..424
                     /gene="USP8"
                     /gene_synonym="HumORF8; PITA4; SPG59; UBPY"
                     /inference="alignment:Splign:2.1.0"
     exon            425..510
                     /gene="USP8"
                     /gene_synonym="HumORF8; PITA4; SPG59; UBPY"
                     /inference="alignment:Splign:2.1.0"
     exon            511..673
                     /gene="USP8"
                     /gene_synonym="HumORF8; PITA4; SPG59; UBPY"
                     /inference="alignment:Splign:2.1.0"
     exon            674..716
                     /gene="USP8"
                     /gene_synonym="HumORF8; PITA4; SPG59; UBPY"
                     /inference="alignment:Splign:2.1.0"
     exon            717..861
                     /gene="USP8"
                     /gene_synonym="HumORF8; PITA4; SPG59; UBPY"
                     /inference="alignment:Splign:2.1.0"
     exon            862..1024
                     /gene="USP8"
                     /gene_synonym="HumORF8; PITA4; SPG59; UBPY"
                     /inference="alignment:Splign:2.1.0"
     exon            1025..1169
                     /gene="USP8"
                     /gene_synonym="HumORF8; PITA4; SPG59; UBPY"
                     /inference="alignment:Splign:2.1.0"
     exon            1170..1393
                     /gene="USP8"
                     /gene_synonym="HumORF8; PITA4; SPG59; UBPY"
                     /inference="alignment:Splign:2.1.0"
     exon            1394..1978
                     /gene="USP8"
                     /gene_synonym="HumORF8; PITA4; SPG59; UBPY"
                     /inference="alignment:Splign:2.1.0"
     exon            1979..2065
                     /gene="USP8"
                     /gene_synonym="HumORF8; PITA4; SPG59; UBPY"
                     /inference="alignment:Splign:2.1.0"
     exon            2066..2146
                     /gene="USP8"
                     /gene_synonym="HumORF8; PITA4; SPG59; UBPY"
                     /inference="alignment:Splign:2.1.0"
     exon            2147..2409
                     /gene="USP8"
                     /gene_synonym="HumORF8; PITA4; SPG59; UBPY"
                     /inference="alignment:Splign:2.1.0"
     exon            2410..2622
                     /gene="USP8"
                     /gene_synonym="HumORF8; PITA4; SPG59; UBPY"
                     /inference="alignment:Splign:2.1.0"
     exon            2623..2833
                     /gene="USP8"
                     /gene_synonym="HumORF8; PITA4; SPG59; UBPY"
                     /inference="alignment:Splign:2.1.0"
     exon            2834..3070
                     /gene="USP8"
                     /gene_synonym="HumORF8; PITA4; SPG59; UBPY"
                     /inference="alignment:Splign:2.1.0"
     exon            3071..3213
                     /gene="USP8"
                     /gene_synonym="HumORF8; PITA4; SPG59; UBPY"
                     /inference="alignment:Splign:2.1.0"
     exon            3214..3346
                     /gene="USP8"
                     /gene_synonym="HumORF8; PITA4; SPG59; UBPY"
                     /inference="alignment:Splign:2.1.0"
     exon            3347..18865
                     /gene="USP8"
                     /gene_synonym="HumORF8; PITA4; SPG59; UBPY"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4196..4201
                     /regulatory_class="polyA_signal_sequence"
                     /gene="USP8"
                     /gene_synonym="HumORF8; PITA4; SPG59; UBPY"
                     /note="hexamer: ATTAAA"
     polyA_site      4220
                     /gene="USP8"
                     /gene_synonym="HumORF8; PITA4; SPG59; UBPY"
                     /note="major polyA site"
     regulatory      5501..5506
                     /regulatory_class="polyA_signal_sequence"
                     /gene="USP8"
                     /gene_synonym="HumORF8; PITA4; SPG59; UBPY"
                     /note="hexamer: AATAAA"
     polyA_site      5527
                     /gene="USP8"
                     /gene_synonym="HumORF8; PITA4; SPG59; UBPY"
     regulatory      9678..9683
                     /regulatory_class="polyA_signal_sequence"
                     /gene="USP8"
                     /gene_synonym="HumORF8; PITA4; SPG59; UBPY"
                     /note="hexamer: AATAAT"
     polyA_site      9705
                     /gene="USP8"
                     /gene_synonym="HumORF8; PITA4; SPG59; UBPY"
     regulatory      18844..18849
                     /regulatory_class="polyA_signal_sequence"
                     /gene="USP8"
                     /gene_synonym="HumORF8; PITA4; SPG59; UBPY"
                     /note="hexamer: AATAAA"
     polyA_site      18865
                     /gene="USP8"
                     /gene_synonym="HumORF8; PITA4; SPG59; UBPY"
ORIGIN      
        1 gagctgggct ggcttccgtc ctggtagcca aggctaattc tccctcgagt tcttgggaga
       61 tgggcatttg gcgagaaggc tggcgttagt gaagcgcgcc cggcgtcacg gaaagaagca
      121 cttgtaagga aatatagcat ccattgtgaa agtggaaaag taaagataat tcatcatgcc
      181 tgctgtggct tcagttccta aagaactcta cctcagttct tcactaaaag accttaataa
      241 gaagacagaa gttaaaccag agaaaataag cactaagagt tatgtgcaca gtgccctgaa
      301 gatctttaag acagcagaag aatgcagatt agatcgtgat gaggaaaggg cctatgtact
      361 atatatgaaa tacgtgactg tttataatct tatcaaaaaa agacctgatt tcaagcaaca
      421 gcaggattat ttccattcaa tacttggacc tggaaacatc aaaaaagctg tcgaagaagc
      481 tgaaagactc tctgaaagcc ttaaattaag atatgaagaa gctgaagtcc ggaaaaaact
      541 tgaggaaaaa gacaggcagg aggaagcaca gcggctacaa caaaaaaggc aggaaacagg
      601 aagagaggat ggtggcacat tggctaaagg ctctttggag aatgttttgg attccaaaga
      661 caaaacccaa aagagcaatg gtgaaaagaa tgaaaaatgt gagaccaaag agaaaggagc
      721 aatcacagca aaggaactat acacaatgat gacggataaa aacatcagct tgattataat
      781 ggatgctcga agaatgcagg attatcagga ttcctgtatt ttacattctc tcagtgttcc
      841 tgaagaagcc atcagtccag gagtcactgc tagttggatt gaagcacacc tgccagatga
      901 ttctaaagac acatggaaga agagggggaa tgtggagtat gtggtacttc ttgactggtt
      961 tagttctgcc aaagatttac agattggaac aactctccgg agtctgaaag atgcactttt
     1021 caagtgggaa agtaaaactg tcctgcgcaa tgagcctttg gttttagagg gaggctatga
     1081 aaactggctc ctttgttatc cccagtatac aacaaatgct aaggtcactc cacccccacg
     1141 acgccagaat gaagaggtgt ctatctcatt ggattttact tatccctcat tggaagaatc
     1201 aattccttct aaacctgctg cccagacgcc acctgcatct atagaagtag atgaaaatat
     1261 agaattgata agtggtcaaa atgagagaat gggaccactg aatatatcaa ctccagttga
     1321 accagttgct gcttctaaat ctgatgtttc acccataatt cagccagtgc ctagtataaa
     1381 gaatgttcca cagattgatc gtactaaaaa accagcagtc aaattgcctg aagagcatag
     1441 aataaaatct gaaagtacaa accatgagca acaatctcct cagagtggaa aagttattcc
     1501 tgatcgttcc accaagccag tagttttttc tccaactctc atgttaacag atgaagaaaa
     1561 ggctcgtatt catgcagaaa ctgctcttct aatggaaaaa aacaaacaag aaaaagaact
     1621 tcgggaaagg cagcaagagg aacagaaaga gaaactgagg aaggaagaac aagaacaaaa
     1681 agccaaaaag aaacaagaag ctgaagaaaa tgaaattaca gagaagcaac aaaaagcaaa
     1741 agaagaaatg gagaagaaag aaagtgaaca ggccaagaaa gaagataaag aaacctcagc
     1801 aaagaggggc aaagaaataa caggagtaaa aagacaaagt aaaagtgaac atgaaacttc
     1861 tgatgccaag aaatctgtag aagatagggg gaaaaggtgt ccaaccccag aaatacagaa
     1921 aaagtcaaca ggagatgtgc cccatacatc tgtgacaggg gattcaggtt caggcaagcc
     1981 atttaagatt aaaggacaac cagaaagtgg aattctaagg acaggaactt ttagagagga
     2041 tacagacgat accgaaagaa ataaagctca acgagaacct ttgacaagag cacgaagtga
     2101 agaaatgggg aggatcgtac caggactgcc ttcaggctgg gccaagtttc ttgacccaat
     2161 cactggaacc tttcgttatt atcattcacc caccaacact gttcatatgt acccaccgga
     2221 aatggctcct tcatctgcac ctccttccac ccctccaact cataaagcca agccacagat
     2281 tcctgctgag cgggataggg aaccttccaa actgaagcgc tcctactcct ccccagatat
     2341 aacccaggct attcaagagg aagagaagag gaagccaaca gtaactccaa cagttaatcg
     2401 ggaaaacaag ccaacatgtt atcctaaagc tgagatctca aggctttctg cttctcagat
     2461 tcggaacctc aatcctgttt ttggaggttc tggaccagct cttactggac ttcgtaactt
     2521 aggaaatact tgttatatga actcaatatt gcagtgccta tgtaacgctc cacatttggc
     2581 tgattatttc aaccgaaact gttatcagga tgatattaac aggtcaaatt tgttggggca
     2641 taaaggtgaa gtggcagaag aatttggtat aatcatgaaa gccctgtgga caggacagta
     2701 tagatatatc agtccaaagg actttaaaat caccattggg aagatcaatg accagtttgc
     2761 aggatacagt cagcaagatt cacaagaatt gcttctgttc ctaatggatg gtctccatga
     2821 agatctaaat aaagctgata atcggaagag atataaagaa gaaaataatg atcatctcga
     2881 tgactttaaa gctgcagaac atgcctggca gaaacacaag cagctcaatg agtctattat
     2941 tgttgcactt tttcagggtc aattcaaatc tacagtacag tgcctcacat gtcacaaaaa
     3001 gtctaggaca tttgaggcct tcatgtattt gtctctacca ctagcatcca caagtaaatg
     3061 tacattacag gattgcctta gattattttc caaagaagaa aaactcacag ataacaacag
     3121 attttactgc agtcattgca gagctcgacg ggattctcta aaaaagatag aaatctggaa
     3181 gttaccacct gtgcttttag tgcatctgaa acgtttttcc tacgatggca ggtggaaaca
     3241 aaaattacag acatctgtgg acttcccgtt agaaaatctt gacttgtcac agtatgttat
     3301 tggtccaaag aacaatttga agaaatataa tttgttttct gtttcaaatc actacggtgg
     3361 gctggatgga ggccactaca cagcctattg taaaaatgca gcaagacaac ggtggtttaa
     3421 gtttgatgat catgaagttt ctgatatctc cgtttcttct gtgaaatctt cagcagctta
     3481 tatcctcttt tatacttcat tgggaccacg agtaactgat gtagccacat aaggagacat
     3541 aggttataaa ctagttatct tttaaaaggc tcagcaacac aactcttgaa atgcttatca
     3601 ggataatggt agctatagct ggccatttag aggaattcta ggacagtggg agctgtgtta
     3661 ctagcactat ataattccgg tcagtgctga caaataacat ttaacaagta ttgcagtaat
     3721 catcacttac aggtaccatt tatttcaaaa caactttttt agtctgctcc aaagttaaaa
     3781 taattaacta gctaagcatt attattcgac tggtctaaaa actattgtta tctttttttt
     3841 ttccttttca ctgttatggc cttttcacat ttctaaatcc catcttgata tactatgaat
     3901 actctagaat gatgtaaagc agataggaat gtatgtgtac atatttattg catacttgca
     3961 catcaaatcg atgtacatag tttaacacgt ggtccttttg tgaaacctag aactcagagg
     4021 attgcttttt ttctttcagc ctattttgag ttaacttcag tgctttctta gggaaatgac
     4081 agggcaaagc aatttttctg ttggctttgg gctgtatttg tgcactaaat ctttattcta
     4141 aaaaaaaaaa tggaaacttt aattttttta aaacgagaat ttcatttaca gctacattaa
     4201 aatcttaatg agaaaaataa tttataaccc tgtgggtgtt ctgtctttaa tattgtatta
     4261 tcaaatatag gacagtaaaa ccatagattt tatatacaca cgtgctatat aataacaccc
     4321 agagtcattc tttcaagact agtattctca catattgaga atattcattc taaatattaa
     4381 agtaaaaatg ccgggagtca ggcatgattg caaagtgaac tgcattataa actacatctt
     4441 tacagagtga tgtattaaga gggttaaagg agcttataat ttatttaacc gagggactca
     4501 gttgctatat atatagtcag taaaacactc catataaaaa taagattcta aaagtgcttc
     4561 agaaagagac caccattagc aggctctcag ggagaagatg aaaggatggg gttcaaattg
     4621 tgaagctgac aacttttcat gttttacaat tagtctaaga gaccacttct tggctaaatt
     4681 attatatcaa atatattcaa atcatattct taaactcatc gagccatttg aacaaaaatt
     4741 atttttgttt agcttcatga gtatctttgg aaaataattt gttgaatata tatgattatg
     4801 agatattttc tgataaacac tgaattttga aacctgaact cactatataa ttgcagtgtt
     4861 ttgaaggcct gcatccatta gcattgcatt atattcacac tgcctttttt agtgaaccaa
     4921 gacccatctt ctggacgaca gatttatctt aagatgaaag gttgtataac atgcccacaa
     4981 ggcataaaaa tgttaatgat gcaagtaagt tctaagagtt taatgaccaa gcaaaactct
     5041 accaccagat gctgactgct tgttttgcag tgttcaggaa acaccatttt cctggctctt
     5101 aacgcttttg tattggtatg gaaaagggct ggcagctata gaacaggaga tccatagcat
     5161 tttgaacaga agtatctgga atctcactga ctcgtgtgtt atcaaagcta tatcaggcct
     5221 gggtgactga attcttgcag aaagcagtgt agtggccacc atccaaatca ccaaaatggt
     5281 tctatgggag aaaggaatgt caaacttagt attcacatat gaacactaac tactggaaca
     5341 gaaatgatag ggccaagaga tgctttttaa attgtccctt attctaaatt aaaaggaagt
     5401 gataattttg ttgttaaatc atgcatatag cctgactgct atattgcttc tcatttcatt
     5461 gtaactactt atatgttgtg cccattgact atcatctgtg aataaagaaa gacaatattt
     5521 agcagcatct gattaatgtt tatcagtgaa catttagtta gcacttaata tacatcaact
     5581 attaagcatt aaaggaaatt ttacaataag aagataattc aggccgggca cagtggctca
     5641 cacctgtaat cccaacactc tgggaggctg aggcaggtgg attgcttgag tccaggagtt
     5701 caagaccagc ctgggcaaaa tagcgagact ccatatcttt taaaggaaaa aaaaaaaaaa
     5761 aaaaaagatg agctaggcat agtggtgcac acctgtagtc ccagctactt gggaagttgg
     5821 ggtgggagga tctctcgagc ctgagaggtc gaggctgcaa tgagccgtga ttgtaccact
     5881 gcactccagc ctgggtgaca gagtgagacc ctgtcttaaa attgtaagtt catttacgta
     5941 agatggcttc tttttttttt ttttaaagtt aggataagcc acagaagaga catttaacat
     6001 tagaataagg atcttaactg catattgcta cagcacaaat tgagggggct atgtagcaac
     6061 aacccctcaa tcccccatag ggtacaaaaa ataatgtatc tcattttcct ttttccatgt
     6121 ctttcctaac ccagtattgt ttggaacaaa ggcattagag aggtgtactt ccaaggaggt
     6181 gttatggtgt atgataaggg tcagcaaacc acggcccgtg ggtcaactcc aggctgtttt
     6241 tgtaagaccc atgcattagc aacgggtttt aaatttttat atggttgggg aaaagatcca
     6301 agtaataata gtattgttat atgtgaaaat tttatgaaat tcaaatgtca atgtccttaa
     6361 agttttatgg gaacacagtc atgctcattt gtttacactt ttcagtggct gctttaatga
     6421 tacaacagta aaactgaata gttgcagcca ataccatatg gcttatgagg cctaaaatat
     6481 ttactgtttg gcctttaaca gaataagttt gctgacctct gctgtagagg aagaaaattg
     6541 attatttgtt aacttatttt taattttttg agatggagtc tctctctgtt gcccaggctg
     6601 gaatgcagtg gcacgatctc ggctcactgc aacctccgcc tcccaggttc aagcaattct
     6661 tctgcctcag ccttccaagt agctgggaga ctacaggtgc ctgccaccat gcccagctaa
     6721 ttttttgtat ttttagtaga gatggggttt cactgtgtta gccaggatgg tctcgatctc
     6781 gacctcggga tcctcccact tcggcctccc aaagttattt atttttattt gagacagagt
     6841 cttgctctgt tgcccaggct ggagtgcagt gacgtgatct cagctcacca caacctctgc
     6901 ttcctgggtt aaagctcttc tcctgcctca gcctcccaag taactgggat tacaggcacg
     6961 caccaccaca cccagctaat tttttgtatt tttagtagag atggggtttc gccgtgttgg
     7021 ccaggctggt cttgaactcc tgacctcaag tgatccacct gcctccacct cccaaagtgc
     7081 tgggattaca ggcgtgagcc actgcaccca gcctatttat ttttagaagc agtttcttgc
     7141 tatgttgccc aggctgtaca tgaattccta ggcacaagca gtcctctcac ttcaggcccc
     7201 caaatagctg ggactacagg catacaccac catgtccaga atgaaaatgg atctgactag
     7261 ttaattccaa cgtgaattcg ggtgtaatag tacattgtga ccttagcgaa attatttgac
     7321 ctttctgagc tttaatttct catctattaa catggcttgt tttgtatagc tgttatcaaa
     7381 tatctcatgt attgagggct agtacacagg agttatttat tcaatattcc cttcaacctt
     7441 cgtcttcccc acctctctcc ttacaggtaa tagaaatatc tgaaattcac atttaaaaga
     7501 tcaaggttcc gccaggcctg gtggctcacg cctgtaatcc cagcactttg ggaggctgag
     7561 gcaggcggat cacttgaggt caggagtttg agactagcct ggccaacatg gtgaaaatcc
     7621 atctcttcta aaaatataaa aattagctgg gcatggtggc gcatgccggt aatcccagct
     7681 acttgggagg ctgaggcaga atcatttgaa cctgggagat ggaggttgca gtgagctgag
     7741 atcatgccat tgcattccag cctgggcgga gccctaaaca ggaaatttaa caacagtatg
     7801 gtgtgtggtt tatgctttgt gactgcctgg gcgtaaagac agtccctagt ttctgtaacc
     7861 agtatgctcg ggttttaaag gtcacgcaag gacactcgag gtaaagtctt aggcccccct
     7921 acaaggtgag aagttggatt gagatccaca tacaaagcca ggacctttaa agacattcac
     7981 cctcaatgga aggattaaaa aacaaaatcc accctctagt gcttgtgtta gcttggactc
     8041 atggtacaga gaataaaagt cattcctggg aatttgtcac catagaccta ccttttcacc
     8101 agtttgggat tcaaatttat actacctgtg tggtctgcga atcctgtgaa cttaatatga
     8161 aaagtatttc tagggcagtt gccagaagga aacagaattt ctagattgtt gcatgttaac
     8221 tcagacctaa caggatatcc acatatgaaa ccccaatgaa gttgagatca caattcaaaa
     8281 taatagaaca tgcaaggaaa caatttatca taagagtcag aaggcaataa gatttaaacc
     8341 cccaaggact ttagataata gaattattaa gcagaggcta caaataaagt atatttaaat
     8401 atatttagaa gaaggaaaca aactttagaa actaaataga attttcagaa atgagaaata
     8461 caacatagtt ggccgtccat atttacgggc tctgcatctt cagaatcaac taatgtgatg
     8521 ggaaagattt gaaaaaataa tacaacaata aaaatataca tattttaaaa tacagtgtaa
     8581 caactattta catagtattt atattgtatt agatattata agtaatccag agatgactta
     8641 aagtatatgg gaggatgtgc ataggttaca tgcaaatact actccaggcc tggcatggtg
     8701 gctcacacgt gtaatcccaa cgtttttggg ggatggaggt gggcagactg cttgagccca
     8761 ggagttgtag accagcctgg gcaacatggc aaaaccctgt ctacacaaaa tacaaaaatt
     8821 gaccaggcat agtggcacgt gcctatagtc ccagctactt ggtaggttga ggtgggagaa
     8881 tcacctgagc ccaggaggtc gaggctacag tgagctgtga ctgagccact gctctccagc
     8941 ctggcaacag aatgagacct tgtctcaaaa aacaaaaaca aaaaacacca gaaaagacac
     9001 cattttatat agggcccttg agcatctgtg gattttgata gtcaaaggga tcctggaacc
     9061 aactccctgc agatactgag gtacaactgt actggaaatt aacttaatga agatattagg
     9121 acacagaaaa tgaataaacc ggactgggcg cggtggctca tgcctgtaat cctagcactt
     9181 tgggaggctg aggcgggtgg accatgaggt caggagttca agaccaacct ggtacacatg
     9241 gtgaaaccct gtctctatta aaaaaaacaa aaaaaattag ctgggcctgg tggcgtgcac
     9301 ctgtaatccc agctacttga gaggctgaag caggagaatc gcttgaaccc gggaggtgga
     9361 ggttgcagtg agccaagatc gtgccattgc actccagtgt gggtgacaga gtgagactcc
     9421 atctcaaaaa aaaaaaaaaa agaataaact ataaaatgaa gttggggaaa ttagcaagaa
     9481 tggagtagtg atggagaata cgtgttaaga ggcatgaaaa attgaatgag aatattcagc
     9541 gtatgtcctg tagaagttct aggaggagag aatcgagtag gggagcaagg caatattaaa
     9601 agtgataatg gctgaaaatg attaatgaga catgaatctt cacatttagg aaatgcagcg
     9661 agccagggat aaataaaaat aatactgcag aacaacagag acaaagagaa aaagcttaaa
     9721 agcaaccaga aagaaaaaga gagtttaccc acaagaatct aacctgctgg tagaagttct
     9781 ccatagcagc catagaaatc agagacaata cagtagcttc aaaataatag agaaaaataa
     9841 ctgtcaatct ggaatttgat ttctagttat catccaagaa tgaaagtgaa ttaaagactt
     9901 ctcaaagact gagagacttc aggataacag accctcactg aaaagcctac tgaaatatat
     9961 gccacatgaa ttttaaaaac tcaatgaagg aagaagtgat acataataga cagtgattaa
    10021 caaaaaagac tgatgaagat ccgggcaaat ataacccaat atgaacagta gaaaaccatg
    10081 ataatgtctc ctttggaggc atattaaaaa attaaaaacc ggctgggcat ggtggttcac
    10141 acctgtaatc ccagcacttt ggaaggccaa ggcaggagga tcgtttgagc ccaggagttt
    10201 gagaccagcc tgggcaacat agtgagacct ggtctctaaa aaaaataaaa aagttggcca
    10261 tgcacagtag catgcctgta gtcccagcta cttggcaggc agaggcagga ggatccctta
    10321 agcccagagt tcaaaactgt agtgagctat gattcattgc actagtgcac tccagtctgg
    10381 gcaacagagt gagaccctgt ctcaaaaaca aaagatgctg aaaacagtag ttcagtgatc
    10441 agaattacag tgttctaaga gctttccatt tctttgggag cagagtataa agatcttgat
    10501 taactttagg ctttaagtat gaaagctgtc gttttttagc ataattacta aagaatcaaa
    10561 atgtgtaact tccaaagttg tagagggaaa ataaagaaag ctttatcagt ttagtagcag
    10621 caagaacaac aggggaaaac aacacagcag aggtccccaa cccccccagg ctgcctgtcc
    10681 ctgacctgtt caggacctgg ctgcacagca ggaagcgagc ggcaaaccta ccctgagcac
    10741 cgcctcctgt cagatcagct gctgcattag attctcacag cagcacaaac tctattgtga
    10801 actgcgcatg tgagggatct aggttgcgtg ctccttatga gaatctactg cctgattttc
    10861 tgaggtggaa cagtttaatc ccaaaaccat gcccgccccg gcccccatcc atgggaaaaa
    10921 aaccgcatca gtggaaaaat tgtcttccac aaaaatcagt ccctggtgcc aacaaggttg
    10981 gggactgccg aattagaaaa ataaggctaa cataaacaca aaagaagatg acgacaagta
    11041 aatccgaatt tattactagt tgaaatatat gggatgtagt aaatttacca aatatttact
    11101 ggattttaaa tatccagttc tagccaggcg cgatggctca cgtctataat ctcagcactt
    11161 ggggaggccg aggggggcgg atcacgaggt caggagatca agactatcct ggccaacacg
    11221 gtgaaacctc atctctacaa aaatacaaaa aattagccgg gcatggtggc aggcgcctat
    11281 agtcccagct actccggagg ctgaggcagg agaatggcat gaacccagga ggtgaagctt
    11341 gcagtgagcc gagatcgtgc cactgcattc cagcctgggc gacagagcga gacttcatct
    11401 caaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaatccagt tttaggccaa gtgtggtggc
    11461 tcatgcctgt aatcccaaca ctttgggagg ccaaggcagg cggatcacct gagatcagga
    11521 gttccagacc accctggcca acatggcaaa acccggtctc tactaaaaat acaaaaatta
    11581 gctgggtctg gtggcacatg ccagtaatcc caactacttg ggaagctgag gcaggagagt
    11641 tgcttgaacc tgggaggtgg aggttgcagt gagccaagat catgccactg cactccagcc
    11701 tggggcacag agtgagactc tgtctctaaa acaaaacaac aacaacaaca aatccagttc
    11761 tatgcactat ataacattta gaactcagaa aaggtgtatt tcccttgagc atcatgttgg
    11821 tgcttaaaat gtttcagatt ttggagcatt ttggattttc agattaggga tgctcaactt
    11881 gtcgtaggta gatatgacca agagaaagct gaagtagcta tacatcagct aaaatggtcc
    11941 ctaagataga atgcattgta aatgagtcac tttataatga aaaaaggttt aaatcaccca
    12001 aattgtataa tttgaaactg ctacctacct aacaaaacag acttgttaaa aacaaatgac
    12061 agaactatag ggaagttttg acaagtctac catcataatg gaagatttca actattgatc
    12121 aagcagacaa aaatattagt atagatacag cttttacaat atatacttag atgagtatct
    12181 gactcctgaa atagaagtgc actgtctcaa caaatgtaaa agagttagtt taggccaggc
    12241 acggtggctc atgcctgtaa tcccagcact ttgggaggcc aaggcaggcg aatcacgagg
    12301 tcaggagttc gagaccagcc tggccaacat ggagaaaccc cgtctctact aaaaatacaa
    12361 aaaattagct gggcatggtg tcggctgcct gtaatcccag ctactgagga ggctgaagca
    12421 ggaaaatcgc ttgaaactgg gcggcggagg ttgcagtgag ccgagatggt gccagtgcac
    12481 tctagcccgg gcgacagtgc aagactctgt ctcaaaaaaa aaaaaaaaaa aaaaaaaaga
    12541 ttagtttaat ttagacccta gtctttgaac acaatacaat tagcagtcaa tacaaaatga
    12601 tacccccaca aaaaatcaat acttttggaa attaaaaaaa cacttctaag taactttata
    12661 aataaattat aaaagtaaaa cacttagaag taaatagtaa tgaaaatact atatcaaaac
    12721 atgggatgca ctgatgtctg agaatgtctt aaaaataata cgatgccaag aagagagtgg
    12781 gtcagtatta agatgaattg atcatttatt ttatattcaa atatcttgct tcagcaagct
    12841 agttgatgga tgcatggcgg tttgttatgc tgtccaattt tgtatatgtt tgaaatattc
    12901 tataataaaa aaaggcagag aaagtgggag atagacattt gtagttttaa atacttatat
    12961 cttaaaggat agactgagtg ttaatacact ggacactcag tttaaaacat taaaacataa
    13021 cagaataaac cctaaaagag tagagggaag agataacact gtaagaggaa taacccataa
    13081 agcagaaaac aaagatgtaa tacagaagat ttaaaaaaag gtaaaagttg gtgttttaag
    13141 acaaaataat ttggatgtta gcctgccaca gtggttcatg cctataatcc ctgcactttg
    13201 ggaggccaag gcagatggat cgcctgagtc caggagtttg aaaccagctt gggcaacatg
    13261 gcaaaacccc gtctctataa aaaaaaaaag agtacaggcc aggcgcggtg gctcacgcct
    13321 gtaatcccag cactttggga ggccgaggcg ggcggatcac gaggtcagga gattgagacc
    13381 atcctggcta acacggtgaa accccatctc tattaaaaat acaaaaaatt acctgggcac
    13441 ggtggcgggc gcctgtagtc ccagctactt gggaggctga ggcaggagaa tggcgtgaac
    13501 ccggggtcgg agcttgcagt gagccaagat cgcgccactg tgctccagcc tgggcgacag
    13561 agcgagactc cgtcacaaaa aaaaaaaaaa aaaaaaaaaa aaaaattaca aaattagctg
    13621 gacatggtgt tgtgcctgta gttccatcta cttgggaggc tgaggtggga ggatggctcg
    13681 agcctgggag gcagaggttg cagtgagcca agatcacacc actgcactcc agcctgggag
    13741 acagagtgag accctctctc aaaaatagta acttggacgt caatagtaag atttagagaa
    13801 taagagacaa ggcggccggg cgcggtggct catgtaatcc cagcactttg gaaggctgag
    13861 gcaggcggat caccaggtca ggaaattgag actatcctgg ctaacacggt gaaacaccgt
    13921 ctctactaaa aatacaaaaa attagccggg catggtggcg ggcgcctgta gtcccaagct
    13981 actcaggagg ctgagacagg agaatgactt gaacccggga ggcggagctt gccgtgagct
    14041 gagatcgtgc cattgcactc cagcctgggc gacagagcga gactgcgtct caaaaaataa
    14101 aataaaataa aataaaataa aaaagagaca agtcaacgat aaaattaaaa atgaaaaaac
    14161 atgtaatagc tacagatcct gaataaattt attgttaata ccctaaaaac tttatgccag
    14221 ccaactgaga ccttagatga aatagacaaa tatctggaga ataagttacc aaaatgactg
    14281 aagagaaata catggctcac acctatattt tttacagaaa ttgacaaggg ccaggaataa
    14341 tcgaaatact actgaaaaat aagaataaag ttgtgatggt aatgacttag ggaataatga
    14401 tggttcttgc tctgccagat atcaatgttt atttcaaagc tatagctata attaatattc
    14461 ataagctaaa ttaagaatta attcaatatt aatttaataa atttaatatt ttatagctat
    14521 aattaataca gtacggaatt agcccaaatg tgaacaaatt gaccaacaga cacacacagc
    14581 ataggaaaac cagcattata tgttactgag gaaaagaaga ggctgagaca tttggttatt
    14641 catatgcaga aaaatgaaat tgaatcccta atttatacta catttttgtc agaagtgcaa
    14701 aacaatttaa atgtttggaa gatatgtagg taaatatctt tgtaattcca gggttggaaa
    14761 ggatttctta aatgagacac agaaaaggac taactagaaa agattgatgt tccaaccaaa
    14821 ttaaaacttg attgtcagca attacaataa gatacaacaa ccaaatgcag tttgtgaatt
    14881 ttggatggat tctggtcttt gaaaaaaaat gctactaaaa aaaaaaacct tgtgacaatt
    14941 gatatttgaa tatgaatcta tgaatatgag tgatggaatt ttaaattttc ttacatataa
    15001 ttctgctatt gtgggtatgt agaagaatgt ggttaaggga ttattttgat ctatgaagtg
    15061 tcacgataca agatttaaat cagcaaaaag ttagatatac gtgtgtatag atgtgcacat
    15121 atatatgtat agagagtgaa agtaataaaa gtgtatacac tgctaaatgt taataactga
    15181 atctagctga aatgtacacc aatgtacacc aatgttttgt tttttggttt tttttttaga
    15241 gatggagtct cgctctgtct cccaggctgg agtgcagtgg cgctatctcg gctcactgca
    15301 agctccgcct cctgggttca cgccattctc ctgcctcagc ctcctgagta gctgggacta
    15361 caggcgcccg ccaccatgcc cggctaattt tttttgtatt tttagtagag acggggtttc
    15421 accgtgttag ccaggatggt ctcgatctcc tgacctcgtg atccgcctgc cttggcctcc
    15481 caaagtgctg ggattacagg cgtcagccac cgtgcccggc cgatgtacac caatgttctc
    15541 tgtacaattc tttcagattt tctgaatgtt tgcaaagttt tattttaaaa actggagaga
    15601 gagcacttga aaagatgctc aacatcatta gtcattagga aaatgcaact caaaaccatg
    15661 acataccagt tcatacctac tttgtatggg atagaataaa aaatgagagg cagtaacaag
    15721 ttcggttgag gatgtgggga aactggaacc ttagttccag ttgctggtgg gaacgtaaaa
    15781 tgctgctgcc actttggaaa acaatttggc agttcctcaa aaaattaacc agagttacca
    15841 tatgacccag aaatttcaca cttaggtata tacccaacag aaatgaaaac atgtttacag
    15901 aaaatcctgt acataaatgt tcatagcagc attactgatg acagccaaaa gtggaaacaa
    15961 gccaaatgtc catcactgga tggattaagg aaatgtggta tatcctatac aatggaatat
    16021 tatttggcaa taaaaaggaa tgaagtacag atacatgcta tgacatgaat gaaacttgaa
    16081 aacattatgc tgaataaaag aaaataaaaa cagaaggtca tatattctat gattctgttt
    16141 attaaaatac ccagaatagg ccaggcactg tggctcacgc ctgtaatccc agcacctggg
    16201 ggagccgagg caggtggatc acttgacgtc tggagtttga gaccagcctg ggcaatatag
    16261 caaaacccca tctcaaccaa aatacacaaa aattattggg gcatggtggt gcacacctgt
    16321 ggtcccagct actcgaggga gggaggaggg aagatcactt gagccaggga ggttgaggct
    16381 gcagtgagct gagattgcac cattgcactc cagcctgagc aagagtgaga tattgtctca
    16441 aaaaataaaa taaataaaat tttaaaaata cgcagaatag gcacatctat agaaatatat
    16501 aaagtagagg ccaggagaag tggttcatgc ctgtaatccg agcactttgg gaggccaagg
    16561 tgggtgcgcc acttgaggtc aggagttcaa gaccagcctg gtcaacatgg tgaaacccca
    16621 cctctactaa aaatacaaaa atacacctgt agtcccagct actcgggagg ctgagttacg
    16681 agaatccctt gaacctggga ggcggaagtt gcagtgagct gaaatcatgc cactgcactc
    16741 cagcctgggc aacagagcaa gactctgtta aaaaaaaaaa aaatagcgag agatcgagag
    16801 agagtgcacg tgagaagact agtagttgct atggactggg ggagaaggaa cgggttacag
    16861 ggtttctttt ggggataacg aaaatgttct aaaactggac tgtggtgata actgcacaac
    16921 tctgtgaatg tactaaaaac tactgaactg gccaggcaca gtggctcaca cctgtaatcc
    16981 cagcactttg ggaggccctg agatgggcag atcacttgag gtcaggagtt ccagaccagt
    17041 ctggccaaca tggtgaaacc acatctctac taaaaatatt tttaaaaatt agccaggcat
    17101 ggtggtgcac ctgtaatccc agctacttgg gaggctgggg catgagaatc atttgaaacc
    17161 agggggtgga ggttgcagtg agccgagatc acaccaccgc actccagcct gggcgacaga
    17221 gccagactct gtctcaaaaa caaacaaaac aaaaacaaca aaaaacacaa ctgaacacat
    17281 ttaaggtgaa ttctgtggta tgtgaactat ctctaagaac ttctttttat ttaagttggg
    17341 aaacaaaaag atcatgtaca acaaaccaaa aacaaaaaag ttatttctaa cccatgtaac
    17401 atataacaag gatctagaac atgtaaatga ctctttccaa tcaataagaa gaaaaataac
    17461 ccagtttgta aaaaatgtgc aaaagacaaa tatttcatac aataggaaaa actaaaatga
    17521 gataattttg tatccattag atggcaaaaa ttaagaagtc tgatgatcct ggtaggggta
    17581 tgtattggta taatcacttg tagaaagtta aatatgcaca tactttatga tctaagtgac
    17641 ctcactccta agtatataca tgagagaaac tcttatgcac atatatatgc aggaatgtct
    17701 gcataatgtt gttcatgcca gcaaaaattt ggaaacaatg aaatatcaat aggaaaatgg
    17761 ataatttatg atatattcac acaatataca tcataggcta gtgaaattat aaccacatgc
    17821 aacaatatgg atatatcttt aaaatattta atgaaaaagt atgcttggcg cggtagctca
    17881 cacctgtaat cccagcactt tgggaggatg agggaggtgg atcacctgag gtcatgagtt
    17941 cgagacaaga gcgaaactgt ctaaaaaaaa aaaaaaaaaa aagagtgaag aatcaagcca
    18001 cagaaggtaa tttaaaaatg tacactcaag atttaaaaag aactacaatt ccataagaaa
    18061 aaggcaggcc acagaatagg aaaaagaata aaagacttgt ttaggcattt cacaaaagaa
    18121 agtatacaaa tttaagtagt tatttaaacc acaatgccat tctactatat gggcaaccag
    18181 aagggccaaa acaaaacgaa caaaagacta ccaagtgtta acaaggattt aaggcaactg
    18241 aaacttccag tcattgctgg tgggggtatg aattggtaca gtcgctttgg aaagctactg
    18301 agcagtatgt actaaagcca gacatatgcg tatttctgaa ccaggagttt cactcctagg
    18361 tatgtactca aaagaactgt gtacactatg ttcaccaaaa aacaagaatg tttatagcaa
    18421 ccctctttgc attagtcaaa agctagtaat tacccaaaag ttcctgaatg gtagaatgaa
    18481 ttactaaatt gtagtatttt catacaatgg aatactatac agcaatgaga atgaataaat
    18541 tacaatataa acaacaatat ggatgaacat tacataattt tgaatgaaag gagccagaca
    18601 caaaaaaagg atatactgta caattccatt tatacgaagc ataaaatcag gcaaaaatct
    18661 ataaatctgt cctgccagaa gtcagtggtt ttccagactc gaaggcaggt acaagcacag
    18721 ttagggtgct ggtaacattc tgtttaaact ctgttctgct ggttacatgg gtatgttcac
    18781 ttgaaaatcc atcaagtttt atcctcatgg tttgtgtact tttctgtata tatgtttcac
    18841 ttcaataaag tttatttttg gtcaa
//
