LOCUS       NM_001304284            8870 bp    mRNA    linear   PRI 28-AUG-2024
DEFINITION  Homo sapiens ubiquitin specific peptidase 6 (USP6), transcript
            variant 1, mRNA.
ACCESSION   NM_001304284 XM_005256845
VERSION     NM_001304284.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 8870)
  AUTHORS   Vuong,M., Mejbel,H.A., Mackinnon,A.C., Roden,D. and Suster,D.I.
  TITLE     Nodular Fasciitis of the Buccal Mucosa with a Novel USP6 Gene
            Rearrangement: A Case Report and Review of the Literature
  JOURNAL   Head Neck Pathol 18 (1), 79 (2024)
   PUBMED   39167308
  REMARK    GeneRIF: Nodular Fasciitis of the Buccal Mucosa with a Novel USP6
            Gene Rearrangement: A Case Report and Review of the Literature.
            Review article
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 8870)
  AUTHORS   Arcovito,G., Crucitta,S., Del Re,M., Caporalini,C., Palomba,A.,
            Nozzoli,F. and Franchi,A.
  TITLE     Recurrent USP6 rearrangement in a subset of atypical
            myofibroblastic tumours of the soft tissues: low-grade
            myofibroblastic sarcoma or atypical/malignant nodular fasciitis?
  JOURNAL   Histopathology 85 (2), 244-253 (2024)
   PUBMED   38651320
  REMARK    GeneRIF: Recurrent USP6 rearrangement in a subset of atypical
            myofibroblastic tumours of the soft tissues: low-grade
            myofibroblastic sarcoma or atypical/malignant nodular fasciitis?
REFERENCE   3  (bases 1 to 8870)
  AUTHORS   Legrand,M., Jourdan,M.L. and de Pinieux,G.
  TITLE     Histopathogenesis of bone- and soft-tissue tumor spectrum with USP6
            gene rearrangement: multiple partners involved in the tissue repair
            process
  JOURNAL   Histol Histopathol 38 (3), 247-260 (2023)
   PUBMED   36205240
  REMARK    GeneRIF: Histopathogenesis of bone- and soft-tissue tumor spectrum
            with USP6 gene rearrangement: multiple partners involved in the
            tissue repair process.
            Review article
REFERENCE   4  (bases 1 to 8870)
  AUTHORS   Obermeier,K.T., Schmockel,E., Otto,S. and Haidari,S.
  TITLE     Frequency of translocation of USP-6 in the aneurysmal bone cyst of
            the jaw
  JOURNAL   J Oral Pathol Med 52 (2), 145-149 (2023)
   PUBMED   36504363
  REMARK    GeneRIF: Frequency of translocation of USP-6 in the aneurysmal bone
            cyst of the jaw.
REFERENCE   5  (bases 1 to 8870)
  AUTHORS   Ogura,Y., Ohbayashi,N., Kanaho,Y., Kawaguchi,A. and Funakoshi,Y.
  TITLE     Ubiquitin-specific protease TRE17/USP6 promotes tumor cell invasion
            through the regulation of glycoprotein CD147 intracellular
            trafficking
  JOURNAL   J Biol Chem 298 (9), 102335 (2022)
   PUBMED   35926707
  REMARK    GeneRIF: Ubiquitin-specific protease TRE17/USP6 promotes tumor cell
            invasion through the regulation of glycoprotein CD147 intracellular
            trafficking.
REFERENCE   6  (bases 1 to 8870)
  AUTHORS   Papa,F.R. and Hochstrasser,M.
  TITLE     The yeast DOA4 gene encodes a deubiquitinating enzyme related to a
            product of the human tre-2 oncogene
  JOURNAL   Nature 366 (6453), 313-319 (1993)
   PUBMED   8247125
REFERENCE   7  (bases 1 to 8870)
  AUTHORS   Onno,M., Nakamura,T., Hillova,J. and Hill,M.
  TITLE     Identification of novel sequences in the repertoire of
            hypervariable TRE17 genes from immortalized nonmalignant and
            malignant human keratinocytes
  JOURNAL   Gene 131 (2), 209-215 (1993)
   PUBMED   8406013
REFERENCE   8  (bases 1 to 8870)
  AUTHORS   Onno,M., Nakamura,T., Mariage-Samson,R., Hillova,J. and Hill,M.
  TITLE     Human TRE17 oncogene is generated from a family of homologous
            polymorphic sequences by single-base changes
  JOURNAL   DNA Cell Biol 12 (2), 107-118 (1993)
   PUBMED   8471161
REFERENCE   9  (bases 1 to 8870)
  AUTHORS   Hoogendijk,J.E., Hensels,G.W., Gabreels-Festen,A.A., Gabreels,F.J.,
            Janssen,E.A., de Jonghe,P., Martin,J.J., van Broeckhoven,C.,
            Valentijn,L.J., Baas,F. et al.
  TITLE     De-novo mutation in hereditary motor and sensory neuropathy type I
  JOURNAL   Lancet 339 (8801), 1081-1082 (1992)
   PUBMED   1349106
REFERENCE   10 (bases 1 to 8870)
  AUTHORS   Nakamura,T., Hillova,J., Mariage-Samson,R., Onno,M., Huebner,K.,
            Cannizzaro,L.A., Boghosian-Sell,L., Croce,C.M. and Hill,M.
  TITLE     A novel transcriptional unit of the tre oncogene widely expressed
            in human cancer cells
  JOURNAL   Oncogene 7 (4), 733-741 (1992)
   PUBMED   1565468
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC012146.25.
            
            On Aug 2, 2019 this sequence version replaced NM_001304284.1.
            
            Transcript Variant: This variant (1) represents the longer
            transcript. Variants 1 and 2 encode the same protein.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BX647719.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA2145245
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000574788.6/ ENSP00000460380.1
            RefSeq Select criteria :: based on expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-709               AC012146.25        64347-65055         c
            710-800             AC012146.25        62797-62887         c
            801-962             AC012146.25        60299-60460         c
            963-1338            AC012146.25        59337-59712         c
            1339-2045           AC012146.25        55815-56521         c
            2046-2163           AC012146.25        55149-55266         c
            2164-2299           AC012146.25        53448-53583         c
            2300-2481           AC012146.25        51954-52135         c
            2482-2635           AC012146.25        50998-51151         c
            2636-2708           AC012146.25        50648-50720         c
            2709-2791           AC012146.25        50403-50485         c
            2792-2831           AC012146.25        48652-48691         c
            2832-2912           AC012146.25        48097-48177         c
            2913-3020           AC012146.25        47537-47644         c
            3021-3130           AC012146.25        47091-47200         c
            3131-3179           AC012146.25        45805-45853         c
            3180-3300           AC012146.25        45159-45279         c
            3301-3395           AC012146.25        44353-44447         c
            3396-3461           AC012146.25        43901-43966         c
            3462-3561           AC012146.25        43337-43436         c
            3562-3714           AC012146.25        42814-42966         c
            3715-4134           AC012146.25        41413-41832         c
            4135-4209           AC012146.25        39588-39662         c
            4210-4348           AC012146.25        38946-39084         c
            4349-4454           AC012146.25        38585-38690         c
            4455-4628           AC012146.25        36224-36397         c
            4629-4803           AC012146.25        35508-35682         c
            4804-4955           AC012146.25        34913-35064         c
            4956-5067           AC012146.25        33893-34004         c
            5068-5279           AC012146.25        32320-32531         c
            5280-5464           AC012146.25        25481-25665         c
            5465-5551           AC012146.25        19473-19559         c
            5552-5672           AC012146.25        18083-18203         c
            5673-5864           AC012146.25        12964-13155         c
            5865-6153           AC012146.25        12032-12320         c
            6154-6590           AC012146.25        10172-10608         c
            6591-6683           AC012146.25        9408-9500           c
            6684-8870           AC012146.25        6096-8282           c
FEATURES             Location/Qualifiers
     source          1..8870
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17p13.2"
     gene            1..8870
                     /gene="USP6"
                     /gene_synonym="HRP1; Tre-2; TRE17; TRE2; TRESMCR;
                     USP6-short"
                     /note="ubiquitin specific peptidase 6"
                     /db_xref="GeneID:9098"
                     /db_xref="HGNC:HGNC:12629"
                     /db_xref="MIM:604334"
     exon            1..709
                     /gene="USP6"
                     /gene_synonym="HRP1; Tre-2; TRE17; TRE2; TRESMCR;
                     USP6-short"
                     /inference="alignment:Splign:2.1.0"
     exon            710..800
                     /gene="USP6"
                     /gene_synonym="HRP1; Tre-2; TRE17; TRE2; TRESMCR;
                     USP6-short"
                     /inference="alignment:Splign:2.1.0"
     exon            801..962
                     /gene="USP6"
                     /gene_synonym="HRP1; Tre-2; TRE17; TRE2; TRESMCR;
                     USP6-short"
                     /inference="alignment:Splign:2.1.0"
     exon            963..1338
                     /gene="USP6"
                     /gene_synonym="HRP1; Tre-2; TRE17; TRE2; TRESMCR;
                     USP6-short"
                     /inference="alignment:Splign:2.1.0"
     exon            1339..2045
                     /gene="USP6"
                     /gene_synonym="HRP1; Tre-2; TRE17; TRE2; TRESMCR;
                     USP6-short"
                     /inference="alignment:Splign:2.1.0"
     exon            2046..2163
                     /gene="USP6"
                     /gene_synonym="HRP1; Tre-2; TRE17; TRE2; TRESMCR;
                     USP6-short"
                     /inference="alignment:Splign:2.1.0"
     exon            2164..2299
                     /gene="USP6"
                     /gene_synonym="HRP1; Tre-2; TRE17; TRE2; TRESMCR;
                     USP6-short"
                     /inference="alignment:Splign:2.1.0"
     exon            2300..2481
                     /gene="USP6"
                     /gene_synonym="HRP1; Tre-2; TRE17; TRE2; TRESMCR;
                     USP6-short"
                     /inference="alignment:Splign:2.1.0"
     exon            2482..2635
                     /gene="USP6"
                     /gene_synonym="HRP1; Tre-2; TRE17; TRE2; TRESMCR;
                     USP6-short"
                     /inference="alignment:Splign:2.1.0"
     exon            2636..2708
                     /gene="USP6"
                     /gene_synonym="HRP1; Tre-2; TRE17; TRE2; TRESMCR;
                     USP6-short"
                     /inference="alignment:Splign:2.1.0"
     CDS             2637..6857
                     /gene="USP6"
                     /gene_synonym="HRP1; Tre-2; TRE17; TRE2; TRESMCR;
                     USP6-short"
                     /EC_number="3.4.19.12"
                     /note="ubiquitin specific protease 6 (Tre-2 oncogene);
                     ubiquitin specific peptidase 6 (Tre-2 oncogene);
                     hyperpolymorphic gene 1; ubiquitin-specific protease USP6;
                     proto-oncogene TRE-2; ubiquitin thioesterase 6;
                     deubiquitinating enzyme 6; ubiquitin-specific-processing
                     protease 6; ubiquitin thiolesterase 6; TBC1D3 and USP32
                     fusion; RN-tre"
                     /codon_start=1
                     /product="ubiquitin carboxyl-terminal hydrolase 6"
                     /protein_id="NP_001291213.1"
                     /db_xref="CCDS:CCDS11069.2"
                     /db_xref="GeneID:9098"
                     /db_xref="HGNC:HGNC:12629"
                     /db_xref="MIM:604334"
                     /translation="MDMVENADSLQAQERKDILMKYDKGHRAGLPEDKGPEPVGINSS
                     IDRFGILHETELPPVTAREAKKIRREMTRTSKWMEMLGEWETYKHSSKLIDRVYKGIP
                     MNIRGPVWSVLLNIQEIKLKNPGRYQIMKERGKRSSEHIHHIDLDVRTTLRNHVFFRD
                     RYGAKQRELFYILLAYSEYNPEVGYCRDLSHITALFLLYLPEEDAFWALVQLLASERH
                     SLPGFHSPNGGTVQGLQDQQEHVVPKSQPKTMWHQDKEGLCGQCASLGCLLRNLIDGI
                     SLGLTLRLWDVYLVEGEQVLMPITSIALKVQQKRLMKTSRCGLWARLRNQFFDTWAMN
                     DDTVLKHLRASTKKLTRKQGDLPPPAKREQGSLAPRPVPASRGGKTLCKGYRQAPPGP
                     PAQFQRPICSASPPWASRFSTPCPGGAVREDTYPVGTQGVPSLALAQGGPQGSWRFLE
                     WKSMPRLPTDLDIGGPWFPHYDFEWSCWVRAISQEDQLATCWQAEHCGEVHNKDMSWP
                     EEMSFTANSSKIDRQKVPTEKGATGLSNLGNTCFMNSSIQCVSNTQPLTQYFISGRHL
                     YELNRTNPIGMKGHMAKCYGDLVQELWSGTQKSVAPLKLRRTIAKYAPKFDGFQQQDS
                     QELLAFLLDGLHEDLNRVHEKPYVELKDSDGRPDWEVAAEAWDNHLRRNRSIIVDLFH
                     GQLRSQVKCKTCGHISVRFDPFNFLSLPLPMDSYMDLEITVIKLDGTTPVRYGLRLNM
                     DEKYTGLKKQLRDLCGLNSEQILLAEVHDSNIKNFPQDNQKVQLSVSGFLCAFEIPVP
                     SSPISASSPTQIDFSSSPSTNGMFTLTTNGDLPKPIFIPNGMPNTVVPCGTEKNFTNG
                     MVNGHMPSLPDSPFTGYIIAVHRKMMRTELYFLSPQENRPSLFGMPLIVPCTVHTRKK
                     DLYDAVWIQVSWLARPLPPQEASIHAQDRDNCMGYQYPFTLRVVQKDGNSCAWCPQYR
                     FCRGCKIDCGEDRAFIGNAYIAVDWHPTALHLRYQTSQERVVDKHESVEQSRRAQAEP
                     INLDSCLRAFTSEEELGESEMYYCSKCKTHCLATKKLDLWRLPPFLIIHLKRFQFVND
                     QWIKSQKIVRFLRESFDPSAFLVPRDPALCQHKPLTPQGDELSKPRILAREVKKVDAQ
                     SSAGKEDMLLSKSPSSLSANISSSPKGSPSSSRKSGTSCPSSKNSSPNSSPRTLGRSK
                     GRLRLPQIGSKNKPSSSKKNLDASKENGAGQICELADALSRGHMRGGSQPELVTPQDH
                     EVALANGFLYEHEACGNGCGDGYSNGQLGNHSEEDSTDDQREDTHIKPIYNLYAISCH
                     SGILSGGHYITYAKNPNCKWYCYNDSSCEELHPDEIDTDSAYILFYEQQGIDYAQFLP
                     KIDGKKMADTSSTDEDSESDYEKYSMLQ"
     exon            2709..2791
                     /gene="USP6"
                     /gene_synonym="HRP1; Tre-2; TRE17; TRE2; TRESMCR;
                     USP6-short"
                     /inference="alignment:Splign:2.1.0"
     exon            2792..2831
                     /gene="USP6"
                     /gene_synonym="HRP1; Tre-2; TRE17; TRE2; TRESMCR;
                     USP6-short"
                     /inference="alignment:Splign:2.1.0"
     exon            2832..2912
                     /gene="USP6"
                     /gene_synonym="HRP1; Tre-2; TRE17; TRE2; TRESMCR;
                     USP6-short"
                     /inference="alignment:Splign:2.1.0"
     exon            2913..3020
                     /gene="USP6"
                     /gene_synonym="HRP1; Tre-2; TRE17; TRE2; TRESMCR;
                     USP6-short"
                     /inference="alignment:Splign:2.1.0"
     exon            3021..3130
                     /gene="USP6"
                     /gene_synonym="HRP1; Tre-2; TRE17; TRE2; TRESMCR;
                     USP6-short"
                     /inference="alignment:Splign:2.1.0"
     exon            3131..3179
                     /gene="USP6"
                     /gene_synonym="HRP1; Tre-2; TRE17; TRE2; TRESMCR;
                     USP6-short"
                     /inference="alignment:Splign:2.1.0"
     exon            3180..3300
                     /gene="USP6"
                     /gene_synonym="HRP1; Tre-2; TRE17; TRE2; TRESMCR;
                     USP6-short"
                     /inference="alignment:Splign:2.1.0"
     exon            3301..3395
                     /gene="USP6"
                     /gene_synonym="HRP1; Tre-2; TRE17; TRE2; TRESMCR;
                     USP6-short"
                     /inference="alignment:Splign:2.1.0"
     exon            3396..3461
                     /gene="USP6"
                     /gene_synonym="HRP1; Tre-2; TRE17; TRE2; TRESMCR;
                     USP6-short"
                     /inference="alignment:Splign:2.1.0"
     exon            3462..3561
                     /gene="USP6"
                     /gene_synonym="HRP1; Tre-2; TRE17; TRE2; TRESMCR;
                     USP6-short"
                     /inference="alignment:Splign:2.1.0"
     exon            3562..3714
                     /gene="USP6"
                     /gene_synonym="HRP1; Tre-2; TRE17; TRE2; TRESMCR;
                     USP6-short"
                     /inference="alignment:Splign:2.1.0"
     exon            3715..4134
                     /gene="USP6"
                     /gene_synonym="HRP1; Tre-2; TRE17; TRE2; TRESMCR;
                     USP6-short"
                     /inference="alignment:Splign:2.1.0"
     exon            4135..4209
                     /gene="USP6"
                     /gene_synonym="HRP1; Tre-2; TRE17; TRE2; TRESMCR;
                     USP6-short"
                     /inference="alignment:Splign:2.1.0"
     exon            4210..4348
                     /gene="USP6"
                     /gene_synonym="HRP1; Tre-2; TRE17; TRE2; TRESMCR;
                     USP6-short"
                     /inference="alignment:Splign:2.1.0"
     exon            4349..4454
                     /gene="USP6"
                     /gene_synonym="HRP1; Tre-2; TRE17; TRE2; TRESMCR;
                     USP6-short"
                     /inference="alignment:Splign:2.1.0"
     exon            4455..4628
                     /gene="USP6"
                     /gene_synonym="HRP1; Tre-2; TRE17; TRE2; TRESMCR;
                     USP6-short"
                     /inference="alignment:Splign:2.1.0"
     exon            4629..4803
                     /gene="USP6"
                     /gene_synonym="HRP1; Tre-2; TRE17; TRE2; TRESMCR;
                     USP6-short"
                     /inference="alignment:Splign:2.1.0"
     exon            4804..4955
                     /gene="USP6"
                     /gene_synonym="HRP1; Tre-2; TRE17; TRE2; TRESMCR;
                     USP6-short"
                     /inference="alignment:Splign:2.1.0"
     exon            4956..5067
                     /gene="USP6"
                     /gene_synonym="HRP1; Tre-2; TRE17; TRE2; TRESMCR;
                     USP6-short"
                     /inference="alignment:Splign:2.1.0"
     exon            5068..5279
                     /gene="USP6"
                     /gene_synonym="HRP1; Tre-2; TRE17; TRE2; TRESMCR;
                     USP6-short"
                     /inference="alignment:Splign:2.1.0"
     exon            5280..5464
                     /gene="USP6"
                     /gene_synonym="HRP1; Tre-2; TRE17; TRE2; TRESMCR;
                     USP6-short"
                     /inference="alignment:Splign:2.1.0"
     exon            5465..5551
                     /gene="USP6"
                     /gene_synonym="HRP1; Tre-2; TRE17; TRE2; TRESMCR;
                     USP6-short"
                     /inference="alignment:Splign:2.1.0"
     exon            5552..5672
                     /gene="USP6"
                     /gene_synonym="HRP1; Tre-2; TRE17; TRE2; TRESMCR;
                     USP6-short"
                     /inference="alignment:Splign:2.1.0"
     exon            5673..5864
                     /gene="USP6"
                     /gene_synonym="HRP1; Tre-2; TRE17; TRE2; TRESMCR;
                     USP6-short"
                     /inference="alignment:Splign:2.1.0"
     exon            5865..6153
                     /gene="USP6"
                     /gene_synonym="HRP1; Tre-2; TRE17; TRE2; TRESMCR;
                     USP6-short"
                     /inference="alignment:Splign:2.1.0"
     exon            6154..6590
                     /gene="USP6"
                     /gene_synonym="HRP1; Tre-2; TRE17; TRE2; TRESMCR;
                     USP6-short"
                     /inference="alignment:Splign:2.1.0"
     exon            6591..6683
                     /gene="USP6"
                     /gene_synonym="HRP1; Tre-2; TRE17; TRE2; TRESMCR;
                     USP6-short"
                     /inference="alignment:Splign:2.1.0"
     exon            6684..8870
                     /gene="USP6"
                     /gene_synonym="HRP1; Tre-2; TRE17; TRE2; TRESMCR;
                     USP6-short"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6987..6992
                     /regulatory_class="polyA_signal_sequence"
                     /gene="USP6"
                     /gene_synonym="HRP1; Tre-2; TRE17; TRE2; TRESMCR;
                     USP6-short"
                     /note="hexamer: ATTAAA"
     polyA_site      7011
                     /gene="USP6"
                     /gene_synonym="HRP1; Tre-2; TRE17; TRE2; TRESMCR;
                     USP6-short"
                     /note="major polyA site"
     regulatory      8848..8853
                     /regulatory_class="polyA_signal_sequence"
                     /gene="USP6"
                     /gene_synonym="HRP1; Tre-2; TRE17; TRE2; TRESMCR;
                     USP6-short"
                     /note="hexamer: ATTAAA"
     polyA_site      8870
                     /gene="USP6"
                     /gene_synonym="HRP1; Tre-2; TRE17; TRE2; TRESMCR;
                     USP6-short"
                     /note="major polyA site"
ORIGIN      
        1 ggacagctag cggcgcggcg ggacgggcgg gccccgacgc ccagctccaa atgcgtggcc
       61 gctgtgggag ctcgtctcca ggcgcccatc agtcttcccc tcactcgacg ctaccttggc
      121 ggccgcgccc atgctgtccc cgctccaact agcagtcagg aggggccgcg ggcagcgctc
      181 gagacgctca ttgagaggac ttcccgcctg cgggctctct gctcgacgcc actcccggcc
      241 ccgctccggg cggcccccct caccactccc ggccccgctc ccggcggccc gcctcaccac
      301 tcccggcttc ccggggctta ggcccgcacc atcgagtcga accgagtcct catgttttcc
      361 tagacaagcc gctgggggag aggggaaaca cttctggccc atgtgagccg ccgtctcgtg
      421 tggtgtctga ggggcgtcta cctggagtca ctgagccgac gaaagggaaa aggccagtgc
      481 ctgtccggga agagctcagc ctagtggggc gggcgacaag ttacagttgc tgccttacga
      541 tggccgtggc ccgtggaggc actagaccct caccaggggt ctgtcaggaa aggcgggcag
      601 atacgtgagg cctgaacagg aaggaactgg gagacccaag actgtaccgc caagaccgct
      661 ttcgagtcgg gccgaccgga atttgaattc gtttcttcac ttactagttg atttttttcc
      721 ttgattcctt cgtgggactc aagacagggg tgccctgttt actcagccca ctgtgctcaa
      781 cctcttgcag gagtgtgcag gaaatgaagg ccctttgagg tcaggtggat gaggatgtca
      841 gtgtgaagat ggacactgtg cctggagtga acctgagctg gatcctgaat gagatgcatg
      901 accaggacaa gaaattggtg gagaagagct acaaggatgc caagggctgt ttcttcagca
      961 tgagagaggg gctgaactgc gaggtggcca ccaacacaga ggccctgcag agcggcagga
     1021 tagagatatg gagctctaca tctctgtgca gaacctgagc catcccagct cagcaaggta
     1081 gggcctctgt cccctcccca ccctgtacct atcaccccag ggtgagccca gccttataga
     1141 cccctgcttg gaggtgtgtt acgggaccca actggcccag ctgcaggggc tcatcagaag
     1201 catggagcag cagctgtgcg agctctgctg cgacgcggag caccaggacc atgagcacca
     1261 ggtccttctg gacgtgaaga cacggctgga gcaggagatc gccacctaca gccgcttgct
     1321 agaggttgag gacgctcaag tcacagggag aagacgtcca cccacacatc aggagacagg
     1381 cctggaacag agccttcctg cacagcctca gaagggaccc accctggtga caccttgatc
     1441 ttggactgac actcatgacc tccagtactg tgagacagta acattctgtt gttgaaggtg
     1501 cccagtctgt ggtactgtaa aacagccctg ggaaactaac gcagcctgtt agcccacaga
     1561 tggtgaaggg atggaatgct ccacggagct ccaggcttac tatctacagc ccccaaagtg
     1621 tgctgcggga cccttgggtg ggtgtaggta tgcaaggtaa ttttgggtgg ttcaaggtga
     1681 ataatttcaa ttgacataat aatgtattta tcttgctggg taaatgaggg atacccaact
     1741 gttaggaacc aggcaacaca gcaggaggtg agcagccagc cagtgagcaa agcttcatct
     1801 gtagaaacag ccacttccca tccctcgcat taccgcatga gctctgcctc ctgtcagatg
     1861 agcggtgccg ttagattctc acagaagcat gaaccctact gtgaactgcg catgccaggg
     1921 atctagattg cgtgctcctt atgagaacct aatgcctgat gatctgtgac tgtctcatca
     1981 ctgccagatg gaaccacgta gttgcaggaa aacaagttca gggctcccac tgattctaca
     2041 ttatggctgg agtgcaatgg cgcaatctcg gctctctgca acttccgcct cctgggttca
     2101 agcaattctc ctgcctcagc ctcccgagta gctgggacta caggcatgtg ccaccatgcc
     2161 tggggctgtc attgggacag tctgagatgg ggagtcgggg gagacaatgg atgaatggat
     2221 ggatgaatgg acagcagtcc agggagatgt ccctgtgtgt cctgaactgg gcccttcctc
     2281 cagtgagaag ccttcctgag ctgacttggg gacagtggct atggtatggg cggtgttggc
     2341 ctctgggcag ctacagagga gggtcatccc tgagcactca ccgggcgccc gttctacact
     2401 gcccatgtag acgattttct ctttcgtctt catggtggct tcgtagagtg ggtgctgttc
     2461 ccgaatgtac ccattcgaca ggaaactggg catctctgtg gccctgaaca tcccaggagg
     2521 ccgatcgtac agagacctct ggtgcctgac cgcagttcac atccacatcc ctggaataga
     2581 ccatcacagg ctcttcaccc ttggcaggtg gacaccattc aacctgccgg ggcaggatgg
     2641 acatggtaga gaatgcagat agtttgcagg cacaggagcg gaaggacata cttatgaagt
     2701 atgacaaggg acaccgagct gggctgccag aggacaaggg gcctgagccc gttggaatca
     2761 acagcagcat tgatcgtttt ggcattttgc atgagacgga gctgcctcct gtgactgcac
     2821 gggaggcgaa gaaaattcgg cgggagatga cacgaacgag caagtggatg gaaatgctgg
     2881 gagaatggga gacatataag cacagtagca aactcataga tcgagtgtac aagggaattc
     2941 ccatgaacat ccggggcccg gtgtggtcag tcctcctgaa cattcaggaa atcaagttga
     3001 aaaaccccgg aagataccag atcatgaagg agaggggcaa gaggtcatct gaacacatcc
     3061 accacatcga cctggacgtg aggacgactc tccggaacca tgtcttcttt agggatcgat
     3121 atggagccaa gcagagggaa ctattctaca tcctcctggc ctattcggag tataacccgg
     3181 aggtgggcta ctgcagggac ctgagccaca tcaccgcctt gttcctcctt tatctgcctg
     3241 aggaggacgc attctgggca ctggtgcagc tgctggccag tgagaggcac tccctgccag
     3301 gattccacag cccaaatggt gggacagtcc aggggctcca agaccaacag gagcatgtgg
     3361 tacccaagtc acaacccaag accatgtggc atcaggacaa ggaaggtcta tgcgggcagt
     3421 gtgcctcgtt aggctgcctt ctccggaacc tgattgacgg gatctctctc gggctcaccc
     3481 tgcgcctgtg ggacgtgtat ttggtggaag gagaacaggt gttgatgcca ataaccagca
     3541 ttgctcttaa ggttcagcag aagcgcctca tgaagacatc caggtgtggc ctgtgggcac
     3601 gtctgcggaa ccaattcttc gatacctggg ccatgaacga tgacaccgtg ctcaagcatc
     3661 ttagggcctc tacgaagaaa ctaacaagga agcaagggga cctgccaccc ccagccaaac
     3721 gcgagcaagg gtccttggca cccaggcctg tgccggcttc acgtggtggg aagaccctct
     3781 gcaaggggta taggcaggcc cctccaggcc caccagccca gttccagcgg cccatttgct
     3841 cagcttcccc gccatgggca tctcgttttt ccacgccctg tcctggtggg gctgtccggg
     3901 aagacacgta ccctgtgggc actcagggtg tgcccagcct ggccctggct cagggaggac
     3961 ctcagggttc ctggagattc ctggagtgga agtcaatgcc ccggctccca acggacctgg
     4021 atataggggg cccttggttc ccccattatg attttgaatg gagctgctgg gtccgtgcca
     4081 tatcccagga ggaccagctg gccacctgct ggcaggctga acactgcgga gaggttcaca
     4141 acaaagatat gagttggcct gaggagatgt cttttacagc aaatagtagt aaaatagata
     4201 gacaaaaggt tcccacagaa aagggagcca caggtctaag caacctggga aacacatgct
     4261 tcatgaactc aagcatccag tgcgttagta acacacagcc actgacacag tattttatct
     4321 cagggagaca tctttatgaa ctcaacagga caaatcccat tggtatgaag gggcatatgg
     4381 ctaaatgcta tggtgattta gtgcaggaac tctggagtgg aactcagaag agtgttgccc
     4441 cattaaagct tcggcggacc atagcaaaat atgctcccaa gtttgatggg tttcagcaac
     4501 aagactccca agaacttctg gcttttctct tggatggtct tcatgaagat ctcaaccgag
     4561 tccatgaaaa gccatatgtg gaactgaagg acagtgatgg ccgaccagac tgggaagtag
     4621 ctgcagaggc ctgggacaac catctaagaa gaaatagatc aattattgtg gatttgttcc
     4681 atgggcagct aagatctcaa gtcaaatgca agacatgtgg gcatataagt gtccgatttg
     4741 accctttcaa ttttttgtct ttgccactac caatggacag ttacatggac ttagaaataa
     4801 cagtgattaa gttagatggt actacccctg tacggtatgg actaagactg aatatggatg
     4861 aaaagtacac aggtttaaaa aaacagctga gggatctctg tggacttaat tcagaacaaa
     4921 tcctactagc agaagtacat gattccaaca taaagaactt tcctcaggat aaccaaaaag
     4981 tacaactctc agtgagcgga tttttgtgtg catttgaaat tcctgtccct tcatctccaa
     5041 tttcagcttc tagtccaaca caaatagatt tctcctcttc accatctaca aatggaatgt
     5101 tcaccctaac taccaatggg gacctaccca aaccaatatt catccccaat ggaatgccaa
     5161 acactgttgt gccatgtgga actgagaaga acttcacaaa tggaatggtt aatggtcaca
     5221 tgccatctct tcctgacagc ccctttacag gttacatcat tgcagtccac cgaaaaatga
     5281 tgaggacaga actgtatttc ctgtcacctc aggagaatcg ccccagcctc tttggaatgc
     5341 cattgattgt tccatgcact gtgcataccc ggaagaaaga cctatatgat gcggtttgga
     5401 ttcaagtatc ctggttagca agaccactcc cacctcagga agctagtatt catgcccagg
     5461 atcgtgataa ctgtatgggc tatcaatatc cattcactct acgagttgtg cagaaagatg
     5521 ggaactcctg tgcttggtgc ccacagtata gattttgcag aggctgtaaa attgattgtg
     5581 gggaagacag agctttcatt ggaaatgcct atattgctgt ggattggcac cccacagccc
     5641 ttcaccttcg ctatcaaaca tcccaggaaa gggttgtaga taagcatgag agtgtggagc
     5701 agagtcggcg agcgcaagcc gagcccatca acctggacag ctgtctccgt gctttcacca
     5761 gtgaggaaga gctaggggaa agtgagatgt actactgttc caagtgtaag acccactgct
     5821 tagcaacaaa gaagctggat ctctggaggc ttccaccctt cctgattatt caccttaagc
     5881 gatttcaatt tgtaaatgat cagtggataa aatcacagaa aattgtcaga tttcttcggg
     5941 aaagttttga tccgagtgct tttttggtac cacgagaccc ggccctctgc cagcataaac
     6001 cactcacacc ccagggggat gagctctcca agcccaggat tctggcaaga gaggtgaaga
     6061 aagtggatgc gcagagttcg gctggaaaag aggacatgct cctaagcaaa agcccatcct
     6121 cactcagcgc taacatcagc agcagcccaa aaggttctcc ttcttcatca agaaaaagtg
     6181 gaaccagctg tccctccagc aaaaacagca gccctaatag cagcccacgg actttgggga
     6241 ggagcaaagg gaggctccgg ctgccccaga ttggcagcaa aaataagccg tcaagtagta
     6301 agaagaactt ggatgccagc aaagagaatg gggctgggca gatctgtgag ctggctgacg
     6361 ccttgagccg agggcatatg cgggggggca gccaaccaga gctggtcact cctcaggacc
     6421 atgaggtagc tttggccaat ggattccttt atgagcatga agcatgtggc aatggctgtg
     6481 gcgatggcta cagcaatggt cagcttggaa accacagtga agaagacagc actgatgacc
     6541 aaagagaaga cactcatatt aagcctattt ataatctata tgcaatttca tgccattcag
     6601 gaattctgag tgggggccat tacatcactt atgccaaaaa cccaaactgc aagtggtact
     6661 gttataatga cagcagctgt gaggaacttc accctgatga aattgacacc gactctgcct
     6721 acattctttt ctatgagcag caggggatag actacgcaca atttctgcca aagattgatg
     6781 gcaaaaagat ggcagacaca agcagtacgg atgaagactc tgagtctgat tacgaaaagt
     6841 actctatgtt acagtaaagc taccactctg gctgctagac agcttggtgg cgagggagat
     6901 gactccttgt agctgatact tggcaaaagt gtcactgaaa gacaagctaa atgtagttat
     6961 tttatcctgt tagaacaaaa attctaatta aaatagttaa cttgaagagt agaaacaatt
     7021 gtattttgaa gtctcataca agctgtctga tagagaactt tcaggcagat cccaccatta
     7081 gcctgtaaac aaaaggtgtg gcaccagcca cctgggacca aataagaatt gaattgtgct
     7141 tgtccagata tgaacaaata tgtagtgagt atagagttta ccaataatca taacaaatat
     7201 taaagatttc cttggagtca gaggaaaaaa caaacaatta taatgttgtc tagggacgac
     7261 atgatacgct acctcctttt tcctgaagtt ttattccatt atattgacaa gatggagaaa
     7321 gcaagatcat gaaggtgtgc aaatgattct tacggcatgg acaaggattt ttcaatttat
     7381 tttttaaact gtttccatac cctttctttt tcttgctttt tgtttttgcc attgtgttta
     7441 cgtttgagac acaaccagtc attggtggca ggggcataga gtggtcagtc tgaaagggag
     7501 gctctcttaa gagctatgtg ccttccaacc agagggagac ccagtagaaa gaaaaacatc
     7561 ctgggaaatc cagctaccag ggccctccca gtggaggcat cttacattta ggctacttca
     7621 agtatcctca gaaatgtatt ctgcaccccc ggccccgccc atgctgaggg aaggggagca
     7681 gttgccaata tttgcaccat cttcacatgc acatgttgca acaagagctt ctgggaaggt
     7741 aagcggcatc ggagctagat cacgtttcac aattagtggt tattcttttc tgtgtttgtt
     7801 ttgcacttta aaaaagagag aacacatgca aatgaacttg cttgtgtgta tttgatggct
     7861 ctaagggcta taaattacaa acaaaacaca tcccagacat taggagttca taagtatatt
     7921 taatgaaatt ggtggtttta ggaagtcaac tttagttttg ctttgtttgc atgtccactg
     7981 gtttttttat tttgatattt gtcttttttt aaattttaca gtagtcattg aaagttatgt
     8041 ttctttgctt acttcatttt ttccctctaa ttatttaaga ttggaacaaa agtataaata
     8101 ttatttattt gaggtagaat ttttttcatg tagtttctta atatatactt gaaggaaatg
     8161 tttcacctta tttttggtct ttgtttattc atttagaccc tgcaagttga ttctcattgc
     8221 cagattccat taccctttct tcctcatagg tagtaattac caatgtaact aagcatttgt
     8281 gttctgatat ctgaggccag taactattaa tatctagttc tcagagcatt tggaaaggtt
     8341 atcttaaatg gctacctaaa ttgaaatcct tttcagaaaa aatataattg caagtaggta
     8401 ggagtggcct aaattgtcta atgtaataaa gtcagacaaa atgcacactt tatagtttca
     8461 agattttcag taaataaaat ctgtccattc ctacctggac atgtcccatt aaaaagtgga
     8521 agattttaaa taatttcttt acagatgttt tatttaaaca ggtagcacaa tctactaatg
     8581 ttgtgtgatt tgtgttatac tggttgtaat taattttttt aattcatgaa ctagcggaaa
     8641 atttattaaa ttaactatta actacattca ccttgtaaat tactgtataa aacttgttga
     8701 caatgcactg actttagaaa gatgttaatg tacataaata gagtgtaaat aaaatagtgt
     8761 tgatgtactg aaatatgaac tgtatcaaaa gtattggtaa ttgtatatgg ggtgtacctg
     8821 tttatctgtt aactattatc caaacaaatt aaatactgtg gttgcctcta
//
