LOCUS       NM_001391956            6792 bp    mRNA    linear   PRI 20-FEB-2025
DEFINITION  Homo sapiens ubiquitin specific peptidase 54 (USP54), transcript
            variant 27, mRNA.
ACCESSION   NM_001391956 XM_017015775
VERSION     NM_001391956.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6792)
  AUTHORS   Wendrich,K., Gallant,K., Recknagel,S., Petroulia,S., Kazi,N.H.,
            Hane,J.A., Fuhrer,S., Bezstarosti,K., O'Dea,R., Demmers,J. and
            Gersch,M.
  TITLE     Discovery and mechanism of K63-linkage-directed deubiquitinase
            activity in USP53
  JOURNAL   Nat Chem Biol (2024) In press
   PUBMED   39587316
  REMARK    Publication Status: Available-Online prior to print
REFERENCE   2  (bases 1 to 6792)
  AUTHORS   Chen,L., Zhang,L., He,H., Shao,F., Yu,Z., Gao,Y. and He,J.
  TITLE     Ubiquitin-specific protease 54 regulates GLUT1-mediated aerobic
            glycolysis to inhibit lung adenocarcinoma progression by modifying
            p53 degradation
  JOURNAL   Oncogene 43 (26), 2025-2037 (2024)
   PUBMED   38744954
  REMARK    GeneRIF: Ubiquitin-specific protease 54 regulates GLUT1-mediated
            aerobic glycolysis to inhibit lung adenocarcinoma progression by
            modifying p53 degradation.
REFERENCE   3  (bases 1 to 6792)
  AUTHORS   Zhou,C., Zhang,X., Ma,H., Zhou,Y., Meng,Y., Chen,C., Shi,G., Yu,W.
            and Zhang,J.
  TITLE     USP54 is a potential therapeutic target in castration-resistant
            prostate cancer
  JOURNAL   BMC Urol 24 (1), 32 (2024)
   PUBMED   38321455
  REMARK    GeneRIF: USP54 is a potential therapeutic target in
            castration-resistant prostate cancer.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 6792)
  AUTHORS   Zhou,Y., Liu,Y., Gupta,S., Paramo,M.I., Hou,Y., Mao,C., Luo,Y.,
            Judd,J., Wierbowski,S., Bertolotti,M., Nerkar,M., Jehi,L.,
            Drayman,N., Nicolaescu,V., Gula,H., Tay,S., Randall,G., Wang,P.,
            Lis,J.T., Feschotte,C., Erzurum,S.C., Cheng,F. and Yu,H.
  TITLE     A comprehensive SARS-CoV-2-human protein-protein interactome
            reveals COVID-19 pathobiology and potential host therapeutic
            targets
  JOURNAL   Nat Biotechnol 41 (1), 128-139 (2023)
   PUBMED   36217030
REFERENCE   5  (bases 1 to 6792)
  AUTHORS   Zhang,C., Ma,X., Wei,G., Zhu,X., Hu,P., Chen,X., Wang,D., Li,Y.,
            Ruan,T., Zhang,W., Tao,K. and Wu,C.
  TITLE     Centrosomal protein 120 promotes centrosome amplification and
            gastric cancer progression via USP54-mediated deubiquitination of
            PLK4
  JOURNAL   iScience 26 (1), 105745 (2022)
   PUBMED   36590171
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 6792)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   7  (bases 1 to 6792)
  AUTHORS   Gordon,D.E., Jang,G.M., Bouhaddou,M., Xu,J., Obernier,K.,
            White,K.M., O'Meara,M.J., Rezelj,V.V., Guo,J.Z., Swaney,D.L.,
            Tummino,T.A., Huttenhain,R., Kaake,R.M., Richards,A.L.,
            Tutuncuoglu,B., Foussard,H., Batra,J., Haas,K., Modak,M., Kim,M.,
            Haas,P., Polacco,B.J., Braberg,H., Fabius,J.M., Eckhardt,M.,
            Soucheray,M., Bennett,M.J., Cakir,M., McGregor,M.J., Li,Q.,
            Meyer,B., Roesch,F., Vallet,T., Mac Kain,A., Miorin,L., Moreno,E.,
            Naing,Z.Z.C., Zhou,Y., Peng,S., Shi,Y., Zhang,Z., Shen,W.,
            Kirby,I.T., Melnyk,J.E., Chorba,J.S., Lou,K., Dai,S.A.,
            Barrio-Hernandez,I., Memon,D., Hernandez-Armenta,C., Lyu,J.,
            Mathy,C.J.P., Perica,T., Pilla,K.B., Ganesan,S.J., Saltzberg,D.J.,
            Rakesh,R., Liu,X., Rosenthal,S.B., Calviello,L., Venkataramanan,S.,
            Liboy-Lugo,J., Lin,Y., Huang,X.P., Liu,Y., Wankowicz,S.A., Bohn,M.,
            Safari,M., Ugur,F.S., Koh,C., Savar,N.S., Tran,Q.D., Shengjuler,D.,
            Fletcher,S.J., O'Neal,M.C., Cai,Y., Chang,J.C.J., Broadhurst,D.J.,
            Klippsten,S., Sharp,P.P., Wenzell,N.A., Kuzuoglu-Ozturk,D.,
            Wang,H.Y., Trenker,R., Young,J.M., Cavero,D.A., Hiatt,J.,
            Roth,T.L., Rathore,U., Subramanian,A., Noack,J., Hubert,M.,
            Stroud,R.M., Frankel,A.D., Rosenberg,O.S., Verba,K.A., Agard,D.A.,
            Ott,M., Emerman,M., Jura,N., von Zastrow,M., Verdin,E.,
            Ashworth,A., Schwartz,O., d'Enfert,C., Mukherjee,S., Jacobson,M.,
            Malik,H.S., Fujimori,D.G., Ideker,T., Craik,C.S., Floor,S.N.,
            Fraser,J.S., Gross,J.D., Sali,A., Roth,B.L., Ruggero,D.,
            Taunton,J., Kortemme,T., Beltrao,P., Vignuzzi,M., Garcia-Sastre,A.,
            Shokat,K.M., Shoichet,B.K. and Krogan,N.J.
  TITLE     A SARS-CoV-2 protein interaction map reveals targets for drug
            repurposing
  JOURNAL   Nature 583 (7816), 459-468 (2020)
   PUBMED   32353859
REFERENCE   8  (bases 1 to 6792)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   9  (bases 1 to 6792)
  AUTHORS   Fraile,J.M., Campos-Iglesias,D., Rodriguez,F., Espanol,Y. and
            Freije,J.M.
  TITLE     The deubiquitinase USP54 is overexpressed in colorectal cancer stem
            cells and promotes intestinal tumorigenesis
  JOURNAL   Oncotarget 7 (46), 74427-74434 (2016)
   PUBMED   27769071
  REMARK    GeneRIF: we have demonstrated that USP54 is overexpressed in colon
            CSCs and promotes both colon carcinoma and melanoma progression.
REFERENCE   10 (bases 1 to 6792)
  AUTHORS   Quesada,V., Diaz-Perales,A., Gutierrez-Fernandez,A., Garabaya,C.,
            Cal,S. and Lopez-Otin,C.
  TITLE     Cloning and enzymatic analysis of 22 novel human ubiquitin-specific
            proteases
  JOURNAL   Biochem Biophys Res Commun 314 (1), 54-62 (2004)
   PUBMED   14715245
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL359074.12.
            
            On Jan 22, 2021 this sequence version replaced XM_017015775.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR18074969.1465792.1,
                                           SRR14038193.4480805.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000687698.1/ ENSP00000510226.1
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-65                AL359074.12        127721-127785       c
            66-629              AL359074.12        112241-112804       c
            630-793             AL359074.12        111955-112118       c
            794-886             AL359074.12        107864-107956       c
            887-1021            AL359074.12        81981-82115         c
            1022-1135           AL359074.12        79461-79574         c
            1136-1218           AL359074.12        79246-79328         c
            1219-1324           AL359074.12        78076-78181         c
            1325-1471           AL359074.12        77818-77964         c
            1472-1621           AL359074.12        75887-76036         c
            1622-1790           AL359074.12        72712-72880         c
            1791-1961           AL359074.12        71043-71213         c
            1962-2093           AL359074.12        67147-67278         c
            2094-2474           AL359074.12        66586-66966         c
            2475-2706           AL359074.12        66123-66354         c
            2707-2840           AL359074.12        63090-63223         c
            2841-3008           AL359074.12        60026-60193         c
            3009-3128           AL359074.12        57351-57470         c
            3129-3324           AL359074.12        56240-56435         c
            3325-4697           AL359074.12        52818-54190         c
            4698-4816           AL359074.12        41751-41869         c
            4817-4957           AL359074.12        41293-41433         c
            4958-5141           AL359074.12        37098-37281         c
            5142-6792           AL359074.12        33981-35631         c
FEATURES             Location/Qualifiers
     source          1..6792
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10q22.2"
     gene            1..6792
                     /gene="USP54"
                     /gene_synonym="bA137L10.3; bA137L10.4; C10orf29"
                     /note="ubiquitin specific peptidase 54"
                     /db_xref="GeneID:159195"
                     /db_xref="HGNC:HGNC:23513"
     exon            1..65
                     /gene="USP54"
                     /gene_synonym="bA137L10.3; bA137L10.4; C10orf29"
                     /inference="alignment:Splign:2.1.0"
     exon            66..629
                     /gene="USP54"
                     /gene_synonym="bA137L10.3; bA137L10.4; C10orf29"
                     /inference="alignment:Splign:2.1.0"
     exon            630..793
                     /gene="USP54"
                     /gene_synonym="bA137L10.3; bA137L10.4; C10orf29"
                     /inference="alignment:Splign:2.1.0"
     CDS             647..5701
                     /gene="USP54"
                     /gene_synonym="bA137L10.3; bA137L10.4; C10orf29"
                     /EC_number="3.4.19.12"
                     /note="isoform 1 is encoded by transcript variant 27;
                     ubiquitin specific protease 54; inactive ubiquitin
                     carboxyl-terminal hydrolase 54; ubiquitin specific
                     proteinase 54; inactive ubiquitin-specific peptidase 54"
                     /codon_start=1
                     /product="ubiquitin carboxyl-terminal hydrolase 54 isoform
                     1"
                     /protein_id="NP_001378885.1"
                     /db_xref="CCDS:CCDS7329.2"
                     /db_xref="GeneID:159195"
                     /db_xref="HGNC:HGNC:23513"
                     /translation="MSWKRNYFSGGRGSVQGMFAPRSSTSIAPSKGLSNEPGQNSCFL
                     NSALQVLWHLDIFRRSFRQLTTHKCMGDSCIFCALKGIFNQFQCSSEKVLPSDTLRSA
                     LAKTFQDEQRFQLGIMDDAAECFENLLMRIHFHIADETKEDICTAQHCISHQKFAMTL
                     FEQCVCTSCGATSDPLPFIQMVHYISTTSLCNQAICMLERREKPSPSMFGELLQNAST
                     MGDLRNCPSNCGERIRIRRVLMNAPQIITIGLVWDSDHSDLAEDVIHSLGTCLKLGDL
                     FFRVTDDRAKQSELYLVGMICYYGKHYSTFFFQTKIRKWMYFDDAHVKEIGPKWKDVV
                     TKCIKGHYQPLLLLYADPQGTPVSTQDLPPQAEFQSYSRTCYDSEDSGREPSISSDTR
                     TDSSTESYPYKHSHHESVVSHFSSDSQGTVIYNVENDSMSQSSRDTGHLTDSECNQKH
                     TSKKGSLIERKRSSGRVRRKGDEPQASGYHSEGETLKEKQAPRNASKPSSSTNRLRDF
                     KETVSNMIHNRPSLASQTNVGSHCRGRGGDQPDKKPPRTLPLHSRDWEIESTSSESKS
                     SSSSKYRPTWRPKRESLNIDSIFSKDKRKHCGYTQLSPFSEDSAKEFIPDEPSKPPSY
                     DIKFGGPSPQYKRWGPARPGSHLLEQHPRLIQRMESGYESSERNSSSPVSLDAALPES
                     SNVYRDPSAKRSAGLVPSWRHIPKSHSSSILEVDSTASMGGWTKSQPFSGEEISSKSE
                     LDELQEEVARRAQEQELRRKREKELEAAKGFNPHPSRFMDLDELQNQGRSDGFERSLQ
                     EAESVFEESLHLEQKGDCAAALALCNEAISKLRLALHGASCSTHSRALVDKKLQISIR
                     KARSLQDRMQQQQSPQQPSQPSACLPTQAGTLSQPTSEQPIPLQVLLSQEAQLESGMD
                     TEFGASSFFHSPASCHESHSSLSPESSAPQHSSPSRSALKLLTSVEVDNIEPSAFHRQ
                     GLPKAPGWTEKNSHHSWEPLDAPEGKLQGSRCDNSSCSKLPPQEGRGIAQEQLFQEKK
                     DPANPSPVMPGIATSERGDEHSLGCSPSNSSAQPSLPLYRTCHPIMPVASSFVLHCPD
                     PVQKTNQCLQGQSLKTSLTLKVDRGSEETYRPEFPSTKGLVRSLAEQFQRMQGVSMRD
                     STGFKDRSLSGSLRKNSSPSDSKPPFSQGQEKGHWPWAKQQSSLEGGDRPLSWEESTE
                     HSSLALNSGLPNGETSSGGQPRLAEPDIYQEKLSQVRDVRSKDLGSSTDLGTSLPLDS
                     WVNITRFCDSQLKHGAPRPGMKSSPHDSHTCVTYPERNHILLHPHWNQDTEQETSELE
                     SLYQASLQASQAGCSGWGQQDTAWHPLSQTGSADGMGRRLHSAHDPGLSKTSTAEMEH
                     GLHEARTVRTSQATPCRGLSRECGEDEQYSAENLRRISRSLSGTVVSEREEAPVSSHS
                     FDSSNVRKPLETGHRCSSSSSLPVIHDPSVFLLGPQLYLPQPQFLSPDVLMPTMAGEP
                     NRLPGTSRSVQQFLAMCDRGETSQGAKYTGRTLNYQSLPHRSRTDNSWAPWSETNQHI
                     GTRFLTTPGCNPQLTYTATLPERSKGLQVPHTQSWSDLFHSPSHPPIVHPVYPPSSSL
                     HVPLRSAWNSDPVPGSRTPGPRRVDMPPDDDWRQSSYASHSGHRRTVGEGFLFVLSDA
                     PRREQIRARVLQHSQW"
     exon            794..886
                     /gene="USP54"
                     /gene_synonym="bA137L10.3; bA137L10.4; C10orf29"
                     /inference="alignment:Splign:2.1.0"
     exon            887..1021
                     /gene="USP54"
                     /gene_synonym="bA137L10.3; bA137L10.4; C10orf29"
                     /inference="alignment:Splign:2.1.0"
     exon            1022..1135
                     /gene="USP54"
                     /gene_synonym="bA137L10.3; bA137L10.4; C10orf29"
                     /inference="alignment:Splign:2.1.0"
     exon            1136..1218
                     /gene="USP54"
                     /gene_synonym="bA137L10.3; bA137L10.4; C10orf29"
                     /inference="alignment:Splign:2.1.0"
     exon            1219..1324
                     /gene="USP54"
                     /gene_synonym="bA137L10.3; bA137L10.4; C10orf29"
                     /inference="alignment:Splign:2.1.0"
     exon            1325..1471
                     /gene="USP54"
                     /gene_synonym="bA137L10.3; bA137L10.4; C10orf29"
                     /inference="alignment:Splign:2.1.0"
     exon            1472..1621
                     /gene="USP54"
                     /gene_synonym="bA137L10.3; bA137L10.4; C10orf29"
                     /inference="alignment:Splign:2.1.0"
     exon            1622..1790
                     /gene="USP54"
                     /gene_synonym="bA137L10.3; bA137L10.4; C10orf29"
                     /inference="alignment:Splign:2.1.0"
     exon            1791..1961
                     /gene="USP54"
                     /gene_synonym="bA137L10.3; bA137L10.4; C10orf29"
                     /inference="alignment:Splign:2.1.0"
     exon            1962..2093
                     /gene="USP54"
                     /gene_synonym="bA137L10.3; bA137L10.4; C10orf29"
                     /inference="alignment:Splign:2.1.0"
     exon            2094..2474
                     /gene="USP54"
                     /gene_synonym="bA137L10.3; bA137L10.4; C10orf29"
                     /inference="alignment:Splign:2.1.0"
     exon            2475..2706
                     /gene="USP54"
                     /gene_synonym="bA137L10.3; bA137L10.4; C10orf29"
                     /inference="alignment:Splign:2.1.0"
     exon            2707..2840
                     /gene="USP54"
                     /gene_synonym="bA137L10.3; bA137L10.4; C10orf29"
                     /inference="alignment:Splign:2.1.0"
     exon            2841..3008
                     /gene="USP54"
                     /gene_synonym="bA137L10.3; bA137L10.4; C10orf29"
                     /inference="alignment:Splign:2.1.0"
     exon            3009..3128
                     /gene="USP54"
                     /gene_synonym="bA137L10.3; bA137L10.4; C10orf29"
                     /inference="alignment:Splign:2.1.0"
     exon            3129..3324
                     /gene="USP54"
                     /gene_synonym="bA137L10.3; bA137L10.4; C10orf29"
                     /inference="alignment:Splign:2.1.0"
     exon            3325..4697
                     /gene="USP54"
                     /gene_synonym="bA137L10.3; bA137L10.4; C10orf29"
                     /inference="alignment:Splign:2.1.0"
     exon            4698..4816
                     /gene="USP54"
                     /gene_synonym="bA137L10.3; bA137L10.4; C10orf29"
                     /inference="alignment:Splign:2.1.0"
     exon            4817..4957
                     /gene="USP54"
                     /gene_synonym="bA137L10.3; bA137L10.4; C10orf29"
                     /inference="alignment:Splign:2.1.0"
     exon            4958..5141
                     /gene="USP54"
                     /gene_synonym="bA137L10.3; bA137L10.4; C10orf29"
                     /inference="alignment:Splign:2.1.0"
     exon            5142..6792
                     /gene="USP54"
                     /gene_synonym="bA137L10.3; bA137L10.4; C10orf29"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6765..6770
                     /regulatory_class="polyA_signal_sequence"
                     /gene="USP54"
                     /gene_synonym="bA137L10.3; bA137L10.4; C10orf29"
                     /note="hexamer: AATAAA"
     polyA_site      6792
                     /gene="USP54"
                     /gene_synonym="bA137L10.3; bA137L10.4; C10orf29"
                     /note="major polyA site"
ORIGIN      
        1 atcacttgcc ccacagatac cctcgtgatt agaggtcttt tgctggaggt tgactgtgct
       61 gtctgctctc tgacacagct ggctattcta gtcccagaag aaagaggaga gacttgctga
      121 agatctggat gggacaatag aagtttgggg cacattaaaa agaagcagca agaacatcaa
      181 caaaaacctc agatgattca aacaggcttc ttcttggctt tgtggaacct tttgcagttg
      241 ctcagaattt gagtttttgc ttcagaggat gatgagacaa ggcaatagag ggtgaggagg
      301 atcatgttgg attcttgctt ctctgtctgc ctctccttcc agttggaaaa atcttcagtc
      361 cataagaagc attatcaaca agcctgaaga acacatctta ccctgatcct ggatgctgtt
      421 ggagttgaga attacatcca cttcaccagg actttatgga ggctgttcaa gaaaaataga
      481 aggaagcaat acttaaggat ttctctgttt gcattagtcc tgtgccatgt tacattttgg
      541 agattgtttg gaacaagtga gggagggctc tgtcatcttg atctaggagg atacctgagt
      601 cccttgacta cacagatgat atttggaagg ctaaatgtga acaataatgt cttggaagag
      661 aaattatttt tcagggggtc gtggtagtgt acaagggatg tttgcacctc gaagctcaac
      721 ctccatagcc cccagcaaag gcctcagcaa tgagccaggg caaaacagct gcttcctcaa
      781 cagtgccctg caggttttgt ggcacttgga tatcttccga cgtagcttta ggcagcttac
      841 aactcacaag tgcatgggag attcctgcat cttttgcgct ctcaagggaa tctttaacca
      901 gtttcagtgt agtagtgaaa aagtgcttcc atctgacact ctccgcagtg ctctggcaaa
      961 gactttccag gatgaacaac gtttccagct gggaattatg gatgatgctg cagagtgctt
     1021 tgaaaacctc ctgatgagaa ttcacttcca cattgctgat gaaaccaaag aggatatatg
     1081 tactgcccaa cactgcattt cccatcagaa atttgcaatg acattgtttg agcagtgtgt
     1141 atgtactagc tgtggtgcca cttctgatcc gctgcctttc atccagatgg tacattatat
     1201 ctccaccact tccctttgca atcaggctat ttgtatgctg gaaagacgag agaaaccttc
     1261 accaagcatg tttggtgagc tgctgcagaa tgccagcacc atgggggatc tgcggaactg
     1321 tccaagcaac tgtggagaga ggatcaggat tcgccgtgtg ttgatgaatg ctccacagat
     1381 tatcacgatt gggctggtat gggactcaga ccactcagac ttagcagaag atgttatcca
     1441 cagcctggga acctgcctta agctgggtga tctgtttttc agagtgacgg atgaccgggc
     1501 caagcaatct gaactgtact tagttggaat gatctgttac tatggcaaac attattctac
     1561 attctttttt caaacaaaga ttcgcaaatg gatgtatttt gatgatgctc atgtcaagga
     1621 gattgggccc aaatggaagg atgtggtgac caaatgcatc aaggggcatt atcagcccct
     1681 gctgctgctt tatgcagatc cccagggtac cccagtttcc acccaggacc tgcctcccca
     1741 agctgagttc cagtcataca gcaggacatg ctacgacagt gaagattcag ggagggagcc
     1801 ctccatctca agtgacactc gaacagattc ctcaacggag agctatccct acaaacattc
     1861 ccaccatgag tctgtggtca gtcacttctc ttctgattct caggggacag tcatctataa
     1921 tgtggaaaat gattccatgt ctcagagcag tcgggacaca ggacacctga ctgatagtga
     1981 atgtaatcag aaacacacat ccaagaaagg gtcactgata gagcgcaaga ggagctctgg
     2041 tcgggttagg aggaaaggcg atgagcccca ggcctcggga taccacagtg aaggagaaac
     2101 actgaaagag aagcaggctc ctagaaatgc ctccaaacca tccagcagca ccaacaggct
     2161 gagagatttt aaagagacag tcagcaatat gatccataac agaccatccc tggcttctca
     2221 gaccaatgta ggctctcact gcaggggcag aggaggagac cagcctgaca aaaaacctcc
     2281 taggaccctg cctttacact ctcgtgactg ggaaatagag agtaccagca gtgagtcaaa
     2341 atccagttct tccagcaagt atcgtcccac atggagaccc aaacgagaat ctctgaatat
     2401 tgacagtatc tttagtaagg acaaaaggaa gcactgtggc tatacccagc ttagcccctt
     2461 ttctgaggat tcagctaaag aatttatacc agatgaacca agcaagccac cttcttacga
     2521 cattaaattt ggtggaccaa gcccccagta caagcgctgg ggcccagcac ggccaggctc
     2581 tcacctttta gagcagcacc cccgactaat ccagcgaatg gaatctggct atgaaagcag
     2641 tgagaggaac agcagcagcc ctgtcagcct ggatgcagcc ctgcctgaga gctcaaatgt
     2701 ctacagggat ccaagtgcta agagatcagc tgggttggtt ccttcctggc gtcatatccc
     2761 aaagtcgcac agcagtagca tcctggaggt agactccaca gcatccatgg gtggctggac
     2821 aaagagtcag cctttctctg gtgaggagat atcttctaaa agtgaactgg atgaattgca
     2881 ggaagaggtg gccaggaggg cgcaggaaca ggaacttcga agaaaacggg agaaggagtt
     2941 agaggcagcg aaagggttta accctcatcc tagccgcttc atggacttgg atgaactgca
     3001 gaatcagggg aggagtgacg gctttgagag gtccctgcaa gaggcagagt cagtgtttga
     3061 agagtcacta catctggaac agaaaggaga ctgtgctgca gctttggctc tctgtaatga
     3121 agctatctct aaactaagac ttgccctgca tggtgccagc tgtagcacgc acagcagagc
     3181 cctagtcgat aagaagttgc aaatcagtat tcgaaaagca cggagcctgc aggatcgcat
     3241 gcagcagcag caatcaccac agcagccgtc gcagccctca gcctgcctcc caacacaggc
     3301 ggggactctc tctcagccaa caagtgaaca gcctatcccg ctccaagtat tgttaagcca
     3361 agaggcccaa ctggaatccg gcatggatac agagtttggg gccagttctt tcttccattc
     3421 acctgcttcc tgccatgagt cacactcatc actatctcca gagtcatctg ccccacagca
     3481 cagctccccc agtagatctg ccttgaagct tctgacttcg gttgaagtag acaacattga
     3541 accctctgca ttccacaggc aaggtttacc taaagcacca gggtggactg agaagaattc
     3601 tcatcatagt tgggagccat tggatgcccc agagggtaag ctgcaaggct ctaggtgtga
     3661 caacagcagt tgcagcaagc tccctccaca agaaggaaga ggcattgctc aagaacagct
     3721 gttccaagaa aagaaggatc ctgctaaccc ctccccggtg atgcctggaa tagccacctc
     3781 tgagaggggt gatgaacaca gcctaggctg tagtccttca aattcatcag ctcagcccag
     3841 ccttcccctg tatagaacct gccaccccat aatgcctgtt gcttcttcat ttgtgcttca
     3901 ctgtcctgat cctgtgcaga aaactaacca atgcctccaa ggccaaagcc tcaaaacttc
     3961 attgacttta aaagtggaca gaggcagtga ggagacctat aggccagagt ttcccagcac
     4021 aaaggggctt gtccgttctc tggctgagca gttccagagg atgcagggtg tctccatgag
     4081 ggatagtaca ggtttcaagg atagaagttt gtcaggtagt ctaaggaaga actcttcccc
     4141 ttctgattct aagcctcctt tctcacaggg tcaagagaaa ggccactggc catgggcaaa
     4201 gcaacaatcc tctctggagg gtggggatag accactttcc tgggaagagt ccactgaaca
     4261 ttcttctctt gccttaaact ctgggctgcc taatggtgaa acttctagcg gaggacagcc
     4321 caggttggca gagccagaca tataccaaga gaagctgtcc caagtgagag atgttaggtc
     4381 taaggatctg ggcagcagta ctgacttggg gacttccttg cctttggatt cctgggtgaa
     4441 tatcacaagg ttctgtgatt ctcagcttaa gcatggggca cctaggccag gaatgaagtc
     4501 ctcccctcat gattcccata cgtgtgtaac ctatccagag agaaatcaca tccttttgca
     4561 tccacattgg aaccaagaca cagagcagga gacctcagaa ttggagtctc tgtatcaggc
     4621 cagtcttcag gcttctcaag ctggctgttc tggatggggg cagcaggata ccgcctggca
     4681 cccacttagc caaacaggct ctgcagatgg catggggagg aggttgcact cagcccatga
     4741 tcctggtctc tcaaagactt caacagcaga aatggagcat ggtctccatg aagccagaac
     4801 agtgcgtact tctcaggcta caccttgccg aggcctcagc agggagtgtg gggaggatga
     4861 gcagtacagt gcagagaatt tacgtcgcat ctcacgcagt ctcagtggca ccgttgtctc
     4921 agagagggag gaagctccgg tttcttccca cagttttgat tcatcaaacg tgaggaagcc
     4981 tttggaaacc gggcaccgtt gttccagctc ctcttccctc cctgtcatcc atgacccttc
     5041 tgtgtttctc ctcggtcccc aactctacct tccccaacca cagttcctgt ccccagatgt
     5101 cctgatgccc accatggcag gggagcccaa tagactccca ggaacttcaa ggagtgtcca
     5161 gcagtttctg gctatgtgtg acaggggtga aacttcccaa ggggccaagt acacaggaag
     5221 gactttgaac taccagagcc tcccccatcg ctccagaaca gacaactcct gggcaccctg
     5281 gtcagagacc aaccagcata ttgggaccag attcctgact actccagggt gcaatcctca
     5341 actaacctac actgccacac taccagaaag aagcaagggc cttcaggttc ctcacactca
     5401 gtcctggagt gatcttttcc attcaccctc ccaccctccc attgttcatc ctgtgtaccc
     5461 accatctagc agtcttcatg tacccctgag gtcagcttgg aattcagatc ctgttccagg
     5521 gtcccgaacc cctggtcctc gaagagtaga tatgccccca gatgatgact ggaggcaaag
     5581 cagttatgcc tcccactctg gacacaggag aacagtggga gaggggtttc tgtttgttct
     5641 atcagatgct cccagaagag agcagatcag ggctagagtc ctgcagcaca gtcaatggta
     5701 aaggttattc ctttcctttc ctggagctac acctttcttt gtaaaactgt actgtgggcc
     5761 gggcgcggtg gctcacacct gtaatcccag cactttggga ggctgaggcg ggtggatcac
     5821 gaggtcagga gattgagacc atcctggcca acatggtgaa accccgtctc taccaaaata
     5881 caaaaaatta gccaggcgtg acggtgcgtg cctgtagtcc caactactcg gaaggctgag
     5941 gcaggagaat tgcttgaacc cgggaggcag aggttgcagt gagccgagat cgcaccactg
     6001 cactccagct tggcaataga gtgagactcc atctcaaaaa acaaaacaaa acaacaacaa
     6061 aataaactac tgtggcagcg ttggtaccct gcatcactgc catggttgtg ctattctcat
     6121 ctcaacatag aattggtggg ttctcctaag ggtgtcagga acctctaaaa agatgtgatt
     6181 ctttgggagg ggatatttga aattccaact tccattcccc ctagcaaaag gaagcagctg
     6241 ctgtttaagg gttttatctg agccacttta aagatgaatc catggtatta ctctggatac
     6301 tagccattcc ttaggatttt aaggtcacat tttattcctg gatgctttat gtccccacct
     6361 ccacctgagc cctcatcctc tgttccctac tatactccca acttctactc tttgttttat
     6421 ccacctatcc ctattacctg accctttgtc ttccctgtct cccatccttg gggggacatg
     6481 tagccctgtg gtcatggttc tgatgacatc atcagggcag cccccctgcc caggtattat
     6541 ggcctgtcag cattccctgt gccctccaaa ccttaggcct agaatgcgga gctgccaaca
     6601 taacattcac ccttttgaac agatggagtc aggcacacta acacagcctt ctgtcctcaa
     6661 taacacagcc attattgcca cttgctcagt cgtcaatgta aaccctcaga gtcagctgaa
     6721 ctattttagg ccaaacatac tgtttttgta aagtattttt cattaataaa tctataagac
     6781 agttctattt aa
//
