LOCUS       XM_047415835            6231 bp    mRNA    linear   PRI 25-AUG-2024
DEFINITION  PREDICTED: Homo sapiens ubiquitin specific peptidase 53 (USP53),
            transcript variant X15, mRNA.
ACCESSION   XM_047415835
VERSION     XM_047415835.1
DBLINK      BioProject: PRJNA168
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000004.12) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2024_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.3
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/23/2024
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..6231
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
     gene            1..6231
                     /gene="USP53"
                     /gene_synonym="PFIC7"
                     /note="ubiquitin specific peptidase 53; Derived by
                     automated computational analysis using gene prediction
                     method: Gnomon. Supporting evidence includes similarity
                     to: 2 mRNAs, 13 ESTs, 721 long SRA reads, and 99% coverage
                     of the annotated genomic feature by RNAseq alignments,
                     including 24 samples with support for all annotated
                     introns"
                     /db_xref="GeneID:54532"
                     /db_xref="HGNC:HGNC:29255"
                     /db_xref="MIM:617431"
     CDS             950..3202
                     /gene="USP53"
                     /gene_synonym="PFIC7"
                     /codon_start=1
                     /product="inactive ubiquitin carboxyl-terminal hydrolase
                     53 isoform X6"
                     /protein_id="XP_047271791.1"
                     /db_xref="GeneID:54532"
                     /db_xref="HGNC:HGNC:29255"
                     /db_xref="MIM:617431"
                     /translation="MAWVKFLRKPGGNLGKVYQPGSMLSLAPTKGLLNEPGQNSCFLN
                     SAVQVLWQLDIFRRSLRVLTGHVCQGDACIFCALKTIFAQFQHSREKALPSDNIRHAL
                     AESFKDEQRFQLGLMDDAAECFENMLERIHFHIVPSRDADMCTSKSCITHQKFAMTLY
                     EQCVCRSCGASSDPLPFTEFVRYISTTALCNEVERMLERHERFKPEMFAELLQAANTT
                     DDYRKCPSNCGQKIKIRRVLMNCPEIVTIGLVWDSEHSDLTEAVVRNLATHLYLPGIG
                     TRWKDVVSKCIRCHFQPLLLFYANPDGTAVSTEDALRQVISWSHYKSVAENMGCEKPV
                     IHKSDNLKENGFGDQAKQRENQKFPTDNISSSNRSHSHTGVGKGPAKLSHIDQREKIK
                     DISRECALKAIEQKNLLSSQRKDLEKGQRKDLGRHRDLVDEDLSHFQSGSPPAPNGFK
                     QHGNPHLYHSQGKGSYKHDRVVPQSRASAQIISSSKSQILAPGEKITGKVKSDNGTGY
                     DTDSSQDSRDRGNSCDSSSKSRNRGWKPMRETLNVDSIFSESEKRQHSPRHKPNISNK
                     PKSSKDPSFSNWPKENPKQKGLMTIYEDEMKQEIGSRSSLESNGKGAEKNKGLVEGKV
                     HGDNWQMQRTESGYESSDHISNGSTNLDSPVIDGNGTVMDISGVKETVCFSDQITTSN
                     LNKERGDCTSLQSQHHLEDHMYMKTMESYFLHPVYKYPRTIMQENISTSQMNRNLKNR
                     MNANFLSGLI"
ORIGIN      
        1 agttcccggt gagcctcggt actgtggcag cagtcagtgt gtctggcggg tgtcggcgtg
       61 aagcggggct gggccagcgg gaggtagctc tgtgggagtg gaaggcctgt atttctctac
      121 ctggaccgca cgctcctcgc gcaaggaggg tagagctcaa gatgcttggg atttgcttta
      181 cattctaagt ggatttggag aagagacaat aaagaataag cagtcaattc tataatatat
      241 ttagaaggag aaaagtgcca aggaggaatg aaaaagtaga acaagagaca gcatcttgct
      301 gccacccagg ctggagtgca gtggtgcagt cttagcttac tgcagcctca aacttctggg
      361 ctcaagtaat cctcccgcct cagcttcctg agtagctgag attacagatt tgctttgagg
      421 tcacattgat atgaaatatg gagtcacctt ttataacttc acctgggaaa gagagagaaa
      481 actttcttgt taaaaaaaca taaggaaaac aaacaaccaa aggaatcatg ccaaatgcca
      541 actctacatc tttttgtatt attaacatat tttatgcatc aagacaaatg gcttatgcat
      601 taaaggggat gattcgttca tcagtatttt tagccattaa aaaaaatcgt tttcatatta
      661 accttataca gctcccataa aatttaacac atataaacat ctttaacgcc ttgtttaaaa
      721 tagctttctt ttttagtgct tagaacttca atgtttatgc accctattgt tacttgtcag
      781 agtctttaag agtttataac atcaggaaag atatggactt ggaaacttac attattaaaa
      841 tagactgcag tggatttaat tggacaattc aagacatcca ttttattgtc caaaatatta
      901 cataaaagtg tacagttttt agcctaaatg caaacaaagt tgcttgaaaa tggcatgggt
      961 aaaattctta cggaaacctg gtggcaatct tggaaaagtt tatcagcctg gaagtatgct
     1021 atcactagcc cctaccaaag gcttgttaaa tgaaccagga caaaacagct gctttcttaa
     1081 tagcgctgta caggttttat ggcaattgga tatattccga cgaagcttgc gggttttgac
     1141 tggacatgtt tgtcagggag atgcctgtat attttgtgca ttgaagacga tatttgcaca
     1201 gttccaacac agtcgagaaa aagcacttcc ctcagataac ataaggcatg ctcttgcaga
     1261 aagtttcaaa gatgagcagc gatttcaact tggccttatg gatgatgctg cggagtgctt
     1321 tgaaaatatg ttggagagga ttcattttca catagtgcca agcagagatg cagacatgtg
     1381 tacctctaaa tcttgtatca ctcaccagaa gtttgctatg actctgtatg aacagtgtgt
     1441 gtgtcgtagc tgtggagcat cgtcagatcc tctacctttt acagaatttg tgcggtacat
     1501 ttctacaaca gccttatgca atgaggttga aagaatgttg gaaaggcatg aacgctttaa
     1561 acctgaaatg tttgcagaat tgctacaagc agcaaataca acagatgact ataggaaatg
     1621 tcctagtaac tgtggccaaa aaataaaaat tcgccgtgtt ttaatgaatt gcccagagat
     1681 tgttacaatt ggtttagtct gggactccga gcattctgac ttgaccgaag ctgttgttcg
     1741 gaatctagca acacatcttt atcttcctgg gattggaact agatggaaag atgttgtctc
     1801 caaatgcatt cgatgccact ttcagccact acttttgttt tatgcaaacc cagatggcac
     1861 agcagtttct actgaggatg cactcaggca ggtcatcagc tggtcacatt acaaatctgt
     1921 tgcagaaaat atgggatgtg aaaagcctgt aattcataag tcagataatt taaaagaaaa
     1981 tggatttggt gatcaggcaa agcagagaga aaatcagaaa tttccaactg ataatatttc
     2041 atcatctaat cggagccaca gtcacacagg tgtagggaaa ggaccagcta agttaagtca
     2101 cattgatcaa agggaaaaga taaaagacat ttccagagaa tgtgctctga aagctattga
     2161 acagaaaaac ttactttctt cacaaaggaa agatttagag aagggacaaa gaaaagattt
     2221 aggacgacat agagatttgg ttgatgaaga cctttcacat ttccaatctg gatcacctcc
     2281 tgccccaaat ggttttaaac aacatgggaa tccacatcta tatcatagtc aaggaaaagg
     2341 atcatataaa catgaccgag ttgtacctca gagtcgagct tctgcacaaa taataagttc
     2401 aagtaaatcc cagattcttg ctccaggaga gaaaataact ggcaaagtta agagtgacaa
     2461 tggcactgga tatgacacag acagcagcca agattctagg gatagaggaa acagctgtga
     2521 tagcagcagt aaaagccgga accgaggttg gaaacctatg agagaaacat taaatgttga
     2581 tagtattttt agtgaaagtg aaaaaagaca gcatagtcca agacataaac caaatatcag
     2641 taataagcct aaatctagca aggatccgag ttttagtaat tggccaaaag agaatccaaa
     2701 gcaaaaaggt ttaatgacca tatatgaaga tgaaatgaag caggaaatag gaagcagaag
     2761 ttcccttgaa tctaatggaa aaggagcaga gaaaaataaa ggccttgtag agggtaaagt
     2821 gcatggtgat aattggcaga tgcaaaggac tgagtctgga tatgaaagca gtgatcacat
     2881 cagtaatggt tctactaatt tggactcacc tgttatcgat ggaaatggta cagtaatgga
     2941 tatcagtggt gttaaagaaa cagtatgctt cagtgaccag attacgacaa gcaacctaaa
     3001 taaagaacgt ggggactgta cctcccttca gagccaacat cacttagaag atcacatgta
     3061 catgaagaca atggaaagtt atttccttca tccagtctac aaatacccaa ggaccataat
     3121 gcaagagaac atatccacca gtcagatgaa cagaaacttg aaaaaccgaa tgaatgcaaa
     3181 ttttctgagt ggcttaatat agaaaattct gagagaacag gtttgccttt tcacgttgat
     3241 aactctgctt ctgggaagag agtgaacagt aatgaaccat cttcattatg gtcttcacac
     3301 ctaagaactg ttgggttaaa gccagaaact gctcctctca tccagcaaca aaatatcatg
     3361 gatcaatgtt actttgagaa ctctctatcc acagaatgta taattcggtc agccagcaga
     3421 tctgatgggt gtcagatgcc aaaacttttt tgccagaatc taccaccccc tttgccacca
     3481 aagaaatatg ctataaccag tgtgccacag tcagagaaaa gcgaatctac acctgatgtc
     3541 aaacttacag aggtgtttaa agctacctct catcttccga agcacagttt aagtacagct
     3601 tcagaaccaa gtttagaagt gagtacacat atgaatgatg aaagacataa agaaacattt
     3661 caagtgagag aatgttttgg caacacacca aactgtccat ccagctcctc aactaacgat
     3721 tttcaggcaa actcaggtgc cattgatgca ttttgccaac cagaactaga ctctatttct
     3781 acctgtccaa atgagacagt ttcattaact acctattttt cagttgatag ctgcatgacg
     3841 gatacatata gattgaaata ccatcagagg cccaagctct cttttccaga gagcagtggc
     3901 ttttgtaata attcactatc ttagagtgaa aaaggactag acctgtgtta cataataatc
     3961 ttggttcaag ctgcccttct gaacaaagat ataaacctag catacattgt aatagataac
     4021 tggtaaaact gaccaacttt tacttctcag aggccattta aatataatag gaacctactg
     4081 accaaaccta gtgatacata aaattaaagc ctgtggcatt tttaaagttg ttaatcacta
     4141 tacatatgta tgtgtatatg tgtatacaca tatataattt tatgatcaat atcttagata
     4201 ttttagaaat tccctttgaa tagtcttggc gtgccgtgaa aaatagaaaa tcagggagat
     4261 ataataattc atttgtcata tgctacagtt gaataaaaat taaatttgtc cccctatttt
     4321 gtggccagta gactgggaag tattaaacta accagtactc atgtatggag attataaact
     4381 atgctaattg aaaagtacca ggtgatacat agcctggtac ttttttgtca aagaattgct
     4441 ttatgaagaa gcactttcta atgggtaacc agaaaagggc ttcacccatt tgtttttgac
     4501 ttctatgata gtcactgcat atgatccctt taagtgtctt taaaaaaaat gacttatgaa
     4561 tttgatagca tttggggaaa aaaagcctta tatgattaac aatttgtaag ttttcaagat
     4621 cggatggaat ttaattttgc tcctagaatt tttgtcttca gaatatctag ttaagataaa
     4681 ttaggccttt gactattata ggtattcata aatgctactt tagccatgta agttaaaaag
     4741 ttaaaatact taaactttag tgtatttatt tatctcgtta ctttttttct aattttatat
     4801 gaaatgtgaa aggtctttat tttggtttgg tttactttgg gctgctaacc accagtgtta
     4861 ggaattaatg tagggcaccc tcttattggg aatgtcactg taattgccta cattttcttt
     4921 gctgtaatat tacctgctta taggttgtca acccatttta tctgaatttg aaaatctatc
     4981 taggtttcca gattaaattt ctacctttca tatagagagt ttaattttaa taaaatgttt
     5041 aattagagca tccttccctt ttattctact ttgaacaaat agtaatttta ccccaactac
     5101 ttttcatgaa gagtgctttg aaaattaaag gaatttttat tattatggta accttatgag
     5161 taaaaataag ttactttaat tgctttattt cgttagttgt cattttattt tgtactatgc
     5221 tggtaaacta attgtggttt agaatagttt tatgttcact cctgataact gagaaacaga
     5281 actaaagttt tccttacatt gctaaatgga taaacctcat attcaataaa ctagtaaatg
     5341 tagccacttg actgattgcg taaatcgtgt taaaacattc taaaatgttg taactaattt
     5401 aatgtgaata ctgttaaaca gaaaataatt gcttataaaa gtctaacttc acccagttac
     5461 caagtcttgg ccaaatttta tcttctgcct atagttttta ctagcctttt taaactataa
     5521 tagtgagtga tcattacttt atattctcgt aagttagaaa tacttgaatg ccaaattaat
     5581 tttgttttaa gaaagcttat ttttaacata attttttagt gtggagggtt tgtaaataat
     5641 gtaaagtttg taaacctgta tttaaaatac caaagttttt cttcttttat aacattgtaa
     5701 gatactagaa aaatgggctt caagtttttt aatagctttc acagtttgtg tagttttttt
     5761 tttctatttg gttaagatgt gagttggaaa tgtattattt gaaacattta aactaatttt
     5821 tgtatttaac agcagtctca gacatttgtc ttttcaactc agttgagttg tagatatcaa
     5881 atagaaatgt ccagttttgc ctcttttaag tactgtccag ttgaaacctc ctgactcatg
     5941 tactactaca caaactagaa aatgcccatt tatttttgtt gattcaacac tccagataca
     6001 gattgataca tatatactaa tcattttatt tcatgtaaaa gttttacatc tagggtgcct
     6061 atttattttt atagatgctt tcatccagtt ataagcttat tataactttg taaatatttc
     6121 agccaacagt tgtaatgttt aaaatactta ccttcagaat gttatatttt catgtgaaat
     6181 caatttcttc taattcaaaa aaattttaag ataaactgat ttttaagttt a
//
