LOCUS       NM_201286               4643 bp    mRNA    linear   PRI 13-FEB-2025
DEFINITION  Homo sapiens ubiquitin specific peptidase 51 (USP51), mRNA.
ACCESSION   NM_201286 XM_017029299 XM_093149
VERSION     NM_201286.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4643)
  AUTHORS   Mu,M., Zhang,Q., Li,J., Zhao,C., Li,X., Chen,Z., Sun,X. and Yu,J.
  TITLE     USP51 facilitates colorectal cancer stemness and chemoresistance by
            forming a positive feed-forward loop with HIF1A
  JOURNAL   Cell Death Differ 30 (11), 2393-2407 (2023)
   PUBMED   37816999
  REMARK    GeneRIF: USP51 facilitates colorectal cancer stemness and
            chemoresistance by forming a positive feed-forward loop with HIF1A.
REFERENCE   2  (bases 1 to 4643)
  AUTHORS   Chen,J., Wu,Z., Deng,W., Tang,M., Wu,L., Lin,N., Chen,L., Fu,Y.,
            Zhao,M., Chen,C. and Li,W.
  TITLE     USP51 promotes non-small cell lung carcinoma cell stemness by
            deubiquitinating TWIST1
  JOURNAL   J Transl Med 21 (1), 453 (2023)
   PUBMED   37422632
  REMARK    GeneRIF: USP51 promotes non-small cell lung carcinoma cell stemness
            by deubiquitinating TWIST1.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4643)
  AUTHORS   Zhou,F., Lu,J., Jin,W., Li,Z., Xu,D. and Gu,L.
  TITLE     The role of USP51 in attenuating chemosensitivity of lung cancer
            cells to cisplatin by regulating DNA damage response
  JOURNAL   Biotechnol Appl Biochem 70 (2), 634-644 (2023)
   PUBMED   35856403
  REMARK    GeneRIF: The role of USP51 in attenuating chemosensitivity of lung
            cancer cells to cisplatin by regulating DNA damage response.
REFERENCE   4  (bases 1 to 4643)
  AUTHORS   Hang,Q., Zeng,L., Wang,L., Nie,L., Yao,F., Teng,H., Deng,Y.,
            Yap,S., Sun,Y., Frank,S.J., Chen,J. and Ma,L.
  TITLE     Non-canonical function of DGCR8 in DNA double-strand break repair
            signaling and tumor radioresistance
  JOURNAL   Nat Commun 12 (1), 4033 (2021)
   PUBMED   34188037
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4643)
  AUTHORS   Zhang,Z., Li,J., Ou,Y., Yang,G., Deng,K., Wang,Q., Wang,Z.,
            Wang,W., Zhang,Q., Wang,H., Sun,W., Sun,P. and Yang,S.
  TITLE     CDK4/6 inhibition blocks cancer metastasis through a
            USP51-ZEB1-dependent deubiquitination mechanism
  JOURNAL   Signal Transduct Target Ther 5 (1), 25 (2020)
   PUBMED   32296027
  REMARK    GeneRIF: CDK4/6 inhibition blocks cancer metastasis through a
            USP51-ZEB1-dependent deubiquitination mechanism.
            Erratum:[Signal Transduct Target Ther. 2020 Jun 19;5(1):103. doi:
            10.1038/s41392-020-00212-9.. PMID: 34145216]
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4643)
  AUTHORS   Wang,Z., Zhang,H., Liu,J., Cheruiyot,A., Lee,J.H., Ordog,T.,
            Lou,Z., You,Z. and Zhang,Z.
  TITLE     USP51 deubiquitylates H2AK13,15ub and regulates DNA damage response
  JOURNAL   Genes Dev 30 (8), 946-959 (2016)
   PUBMED   27083998
  REMARK    GeneRIF: USP51 is the deubiquitylating enzyme for H2AK13,15ub and
            regulates DNA damage response
REFERENCE   7  (bases 1 to 4643)
  AUTHORS   Argos,M., Tong,L., Pierce,B.L., Rakibuz-Zaman,M., Ahmed,A.,
            Islam,T., Rahman,M., Paul-Brutus,R., Rahaman,R., Roy,S.,
            Jasmine,F., Kibriya,M.G. and Ahsan,H.
  TITLE     Genome-wide association study of smoking behaviours among
            Bangladeshi adults
  JOURNAL   J Med Genet 51 (5), 327-333 (2014)
   PUBMED   24665060
REFERENCE   8  (bases 1 to 4643)
  AUTHORS   Puente,X.S. and Lopez-Otin,C.
  TITLE     A genomic analysis of rat proteases and protease inhibitors
  JOURNAL   Genome Res 14 (4), 609-622 (2004)
   PUBMED   15060002
REFERENCE   9  (bases 1 to 4643)
  AUTHORS   Quesada,V., Diaz-Perales,A., Gutierrez-Fernandez,A., Garabaya,C.,
            Cal,S. and Lopez-Otin,C.
  TITLE     Cloning and enzymatic analysis of 22 novel human ubiquitin-specific
            proteases
  JOURNAL   Biochem Biophys Res Commun 314 (1), 54-62 (2004)
   PUBMED   14715245
REFERENCE   10 (bases 1 to 4643)
  AUTHORS   Puente,X.S., Sanchez,L.M., Overall,C.M. and Lopez-Otin,C.
  TITLE     Human and mouse proteases: a comparative genomic approach
  JOURNAL   Nat Rev Genet 4 (7), 544-558 (2003)
   PUBMED   12838346
  REMARK    Review article
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL590410.13.
            This sequence is a reference standard in the RefSeqGene project.
            
            On or before Sep 17, 2020 this sequence version replaced
            XM_017029299.1, NM_201286.3.
            
            Sequence Note:.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: ERR4352444.740097.1,
                                           SRR14038193.4083658.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968189
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000500968.4/ ENSP00000423333.2
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-73                AL590410.13        129722-129794       c
            74-270              AL590410.13        129115-129311       c
            271-4643            AL590410.13        124562-128934       c
FEATURES             Location/Qualifiers
     source          1..4643
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /map="Xp11.21"
     gene            1..4643
                     /gene="USP51"
                     /note="ubiquitin specific peptidase 51"
                     /db_xref="GeneID:158880"
                     /db_xref="HGNC:HGNC:23086"
     exon            1..73
                     /gene="USP51"
                     /inference="alignment:Splign:2.1.0"
     exon            74..270
                     /gene="USP51"
                     /inference="alignment:Splign:2.1.0"
     exon            271..4643
                     /gene="USP51"
                     /inference="alignment:Splign:2.1.0"
     CDS             320..2455
                     /gene="USP51"
                     /EC_number="3.4.19.12"
                     /note="ubiquitin thiolesterase 51; deubiquitinating enzyme
                     51; ubiquitin thioesterase 51;
                     ubiquitin-specific-processing protease 51"
                     /codon_start=1
                     /product="ubiquitin carboxyl-terminal hydrolase 51"
                     /protein_id="NP_958443.1"
                     /db_xref="CCDS:CCDS14370.1"
                     /db_xref="GeneID:158880"
                     /db_xref="HGNC:HGNC:23086"
                     /translation="MAQVRETSLPSGSGVRWISGGGGGASPEEAVEKAGKMEEAAAGA
                     TKASSRREAEEMKLEPLQEREPAPEENLTWSSSGGDEKVLPSIPLRCHSSSSPVCPRR
                     KPRPRPQPRARSRSQPGLSAPPPPPARPPPPPPPPPPPAPRPRAWRGSRRRSRPGSRP
                     QTRRSCSGDLDGSGDPGGLGDWLLEVEFGQGPTGCSHVESFKVGKNWQKNLRLIYQRF
                     VWSGTPETRKRKAKSCICHVCSTHMNRLHSCLSCVFFGCFTEKHIHKHAETKQHHLAV
                     DLYHGVIYCFMCKDYVYDKDIEQIAKETKEKILRLLTSTSTDVSHQQFMTSGFEDKQS
                     TCETKEQEPKLVKPKKKRRKKSVYTVGLRGLINLGNTCFMNCIVQALTHIPLLKDFFL
                     SDKHKCIMTSPSLCLVCEMSSLFHAMYSGSRTPHIPYKLLHLIWIHAEHLAGYRQQDA
                     HEFLIAILDVLHRHSKDDSGGQEANNPNCCNCIIDQIFTGGLQSDVTCQACHSVSTTI
                     DPCWDISLDLPGSCATFDSQNPERADSTVSRDDHIPGIPSLTDCLQWFTRPEHLGSSA
                     KIKCNSCQSYQESTKQLTMKKLPIVACFHLKRFEHVGKQRRKINTFISFPLELDMTPF
                     LASTKESRMKEGQPPTDCVPNENKYSLFAVINHHGTLESGHYTSFIRQQKDQWFSCDD
                     AIITKATIEDLLYSEGYLLFYHKQGLEKD"
     regulatory      4621..4626
                     /regulatory_class="polyA_signal_sequence"
                     /gene="USP51"
                     /note="hexamer: AATAAA"
     polyA_site      4643
                     /gene="USP51"
                     /note="major polyA site"
ORIGIN      
        1 agagaaggct ggctgaggag cgcctggaca gcagcagttg ctgacgttct atatcacgcg
       61 cctggggccc aaggatacag ggaaagaacg tcagaggaag ctgcaccaaa gcgaggctgc
      121 gcagggcgca aaaaagcagt cagagggtgg cgcctttttt aaagaagttt ccatcctttc
      181 tgtcctaaag ctcaggccgt tccccacccc caccgctcgc tagccttctg ttcccagtcc
      241 cctggcatga tctgatcgcc tttgaagcag tcgcagctgt tttccagacg ccttgctcct
      301 caggtcgggg agtgatctga tggcccaggt tcgagaaact tctttgccct ccggctctgg
      361 ggtccgctgg atctccggag gtgggggagg agcctctcct gaggaggcgg ttgagaaggc
      421 ggggaaaatg gaggaggcgg cggcgggggc tacgaaggcg tcttcgagac gtgaagccga
      481 ggagatgaag ctggagccat tacaagagcg tgagcccgcg ccggaggaga acttgacgtg
      541 gagcagcagc ggcggcgacg agaaggtgct cccttcaatc ccccttcgct gtcacagcag
      601 ctcctcgccc gtttgcccgc gccgcaagcc ccgccctcgg ccccagcccc gggcccgctc
      661 ccgcagccag cctgggctct cggccccacc cccgcctcca gcccggcccc cgcccccgcc
      721 gccacccccg cccccacccg caccgcggcc cagggcctgg cgtggatccc ggcgcagatc
      781 ccggcctggg tccaggcctc agacacggag aagctgctct ggtgacctag acgggtcggg
      841 ggatcctggc ggcttagggg actggttgct ggaggtcgag tttggtcagg gtcccacagg
      901 ctgctctcat gtggagagct ttaaagtagg taagaactgg cagaagaacc tgaggttgat
      961 ctaccagcgt ttcgtttgga gtgggacccc agagactagg aaacgtaaag caaagtcatg
     1021 catctgtcac gtatgtagta cccatatgaa cagactccac tcttgtctct cctgtgtctt
     1081 ttttggctgc ttcactgaga aacatattca caaacatgca gaaacaaagc agcaccattt
     1141 agctgtagac ctttatcatg gggtcatata ttgcttcatg tgtaaggatt atgtatatga
     1201 caaagacata gaacagattg ccaaagaaac aaaagaaaaa attttgagat tattaacttc
     1261 cacctcaaca gatgtttctc atcaacagtt tatgacatca gggtttgaag acaagcaatc
     1321 aacctgtgag acaaaggaac aggagccaaa attggtgaaa cccaagaaaa agagaagaaa
     1381 aaagtcagtc tatactgtag gcctgagagg gctaatcaat cttgggaaca cttgttttat
     1441 gaattgtatt gtccaggcac ttacccatat tcctctactg aaagatttct tcctctctga
     1501 caagcacaaa tgtataatga caagccccag cttgtgtctg gtctgtgaaa tgtcttcgct
     1561 ttttcatgct atgtactctg ggagccgaac tcctcacatt ccctataagt tactgcatct
     1621 gatatggatc catgcagaac atttagcagg gtacaggcag caggatgccc atgagttcct
     1681 tattgcaata ttagacgtgc tacatagaca cagcaaagat gatagtggtg ggcaggaggc
     1741 caataacccc aactgctgta actgcatcat agaccaaatc tttacaggtg gcctgcaatc
     1801 agatgtcaca tgtcaagcct gccatagtgt ttctaccacc atagacccat gctgggacat
     1861 cagtttggac ttgcctggct cttgtgccac attcgattcc cagaacccag agagggctga
     1921 cagcacagtg agcagggatg accacatacc aggaatcccc tcacttacag actgtctaca
     1981 gtggtttaca aggccagagc acctaggaag cagtgccaaa atcaaatgca atagttgcca
     2041 aagctaccag gagtctacta aacagctcac aatgaaaaaa ttacccattg tggcttgttt
     2101 tcatctcaag cggtttgagc atgtaggcaa acagaggcga aagattaata cctttatctc
     2161 ctttcccttg gagctggaca tgactccgtt tttggcctct actaaagaga gcagaatgaa
     2221 agaaggccag ccaccaacag attgtgtgcc caatgagaat aagtattcct tgtttgcagt
     2281 gattaatcac catggaactt tggaaagtgg ccactatacc agcttcatcc ggcaacaaaa
     2341 ggaccagtgg ttcagctgtg atgatgccat catcaccaag gctaccattg aggacttact
     2401 ctacagtgaa gggtatttac tgttctatca caaacagggt ctagagaaag actagtctta
     2461 ccagaccact tactgaaaaa aaagtaaatg attaggcaag gattttgaag tgacacacag
     2521 acctacttgg aatggacaat gacagtaaca cctatgtgac agctagtatc ttgatataaa
     2581 gaacctattt tagcatggcc catgggtctg tcggaagaaa aaaatgaata ctaaccagtg
     2641 accattcaac cttaagaaat ggggagaggg agaagaggtt gaaaatggtc acataaagca
     2701 taatgaaatg aaaagaatgc tttaggtggg gacaacggga gtagaagtgt tctgatgcta
     2761 ctctatgtca tttgttttta cagaaatatc ttgtgaagtc agggagtatt cctttatcag
     2821 caaaaacttc acaattggtg ttccagctgt ggctgaccag ctaaatagtt tgaaagaaaa
     2881 ataatatttt aaaataaagt ttaaagagct ttaaaagaaa aacatttaaa aaggaaaaaa
     2941 tcatttttaa gattttaaaa gaaaaaaact tttaaatgtt gaaaaaaatt taagttgtta
     3001 tttttaaaag aaatatttta aaagttaaaa ataatttttt aatttaaaga agtttcagaa
     3061 ttttaaaaat taaaagcaaa gaaaattaaa ttcttaaagt ttaaaaatgt aaaataaatt
     3121 aaggaacaag gttaaaaatg aaagtttacc aaaaaaagga agaaaatact gttaaaaatt
     3181 aaagttagaa acaaaggaac atcttaaaag tttcaaatga aggaaaataa tataaataga
     3241 tatttcaaaa ttaaagcata aaatatacgt atttaaaaag tgttaacaaa attactacta
     3301 taatgattaa gaaataaatt ttcaaaaata cagaatggaa tgcaattcag attttagaga
     3361 aaagttttaa aagaggcaag tttagaataa ttcaagacaa aaagacaaaa tgtgtttaaa
     3421 gacaaaaatt gaaaaaatac aggaagaaaa tagagacttg taaaataaaa agaaccttag
     3481 ataagttcaa gagatttaaa tgaaaacttt aaatatttaa ataaagattt aaaaatttaa
     3541 gcttttaaaa agaaaaacag ttacataaaa attgaccagt gaaaaaatgt gaaagattca
     3601 agtagaaaaa attattaaaa ttaaaagttt aagaagttct atttttttat ttaagcatat
     3661 taaaatacag acgggtatga aagaaataaa tggaggagac aggaataacg acagcggtgt
     3721 gtgagtatat atatatatat atattttttt ttttgagctt tatgttgata tatcaatata
     3781 cgttggaaaa ggaaatagac attttaatca ttatcttacc atccaattgt gaaatggctg
     3841 caaggcctaa acactaacta acccaccttc ccctcttgag attccatgcc ccatctcata
     3901 tcctgaagga agtcaaatta cttcctaggc agaatcaatt catctgagaa aaatgaaaac
     3961 attagggact ttcccattta gaactgcatt attcatacaa attcttagct tctgaaaagg
     4021 ggctcttgat aatttggtgg cttagagaag ttagatcaca gctgtgaagc tctggctttg
     4081 gtatttgagc cccatggcct gattgaggaa gtggcaggga cccatatctg aggccttccc
     4141 accttccttt ttccctcttc cccctccaag gagaaacaag acctttaatt tccacagtag
     4201 agcaatgggt ttgtgcttgc agtccttctg ctcattcttt attccctctt tatttccttt
     4261 ttttgtcact catgcctagt tccctgaacc ccttacttac ctggccttac ctacatctct
     4321 gagccccagc ctgcagggct ccttctttga ctattcacct ggtggctttt actcctcctt
     4381 caagacccaa ctcacagatg acttctctgg agtcttccct gaatgctcta ggcaggtata
     4441 aatgagaaaa ttgttcctct cttcccctct ttattcctct cactgtgcct ccaaagtact
     4501 ttgtccatac ctcggtgata gtacttattc tactgtgatt ttattgtagc tttgtgattg
     4561 tctgcccctc tgcactgagc atctaagaac agggggccaa gccttattca tttctgtgtt
     4621 aataaatatt tgttaaatgt gaa
//
