LOCUS       NM_001286554            8940 bp    mRNA    linear   PRI 12-FEB-2025
DEFINITION  Homo sapiens ubiquitin specific peptidase 49 (USP49), transcript
            variant 1, mRNA.
ACCESSION   NM_001286554 XM_005248991
VERSION     NM_001286554.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 8940)
  AUTHORS   Kaushal,K., Kim,E.J., Tyagi,A., Karapurkar,J.K., Haq,S., Jung,H.S.,
            Kim,K.S. and Ramakrishna,S.
  TITLE     Genome-wide screening for deubiquitinase subfamily identifies
            ubiquitin-specific protease 49 as a novel regulator of
            odontogenesis
  JOURNAL   Cell Death Differ 29 (9), 1689-1704 (2022)
   PUBMED   35273362
  REMARK    GeneRIF: Genome-wide screening for deubiquitinase subfamily
            identifies ubiquitin-specific protease 49 as a novel regulator of
            odontogenesis.
REFERENCE   2  (bases 1 to 8940)
  AUTHORS   Matsui,M., Kajita,S., Tsuchiya,Y., Torii,W., Tamekuni,S. and
            Nishi,R.
  TITLE     USP49 is a novel deubiquitylating enzyme for gamma H2AX in DNA
            double-strand break repair
  JOURNAL   Gene 833, 146599 (2022)
   PUBMED   35598681
  REMARK    GeneRIF: USP49 is a novel deubiquitylating enzyme for gamma H2AX in
            DNA double-strand break repair.
REFERENCE   3  (bases 1 to 8940)
  AUTHORS   Tu,R., Kang,W., Kang,Y., Chen,Z., Zhang,P., Xiong,X., Ma,J.,
            Du,R.L. and Zhang,C.
  TITLE     c-MYC-USP49-BAG2 axis promotes proliferation and chemoresistance of
            colorectal cancer cells in vitro
  JOURNAL   Biochem Biophys Res Commun 607, 117-123 (2022)
   PUBMED   35367823
  REMARK    GeneRIF: c-MYC-USP49-BAG2 axis promotes proliferation and
            chemoresistance of colorectal cancer cells in vitro.
REFERENCE   4  (bases 1 to 8940)
  AUTHORS   Liu,Z., Li,J., Ding,Y., Ma,M., Chen,J., Lei,W., Li,L., Yao,Y.,
            Yu,X., Zhong,M., Liao,Q., Fang,W., Fan,L., Huang,C., Zhong,H.,
            Wen,Q., Fang,Z., Chen,J., Huang,S., Xiong,J., Xiang,X. and Deng,J.
  TITLE     USP49 mediates tumor progression and poor prognosis through a
            YAP1-dependent feedback loop in gastric cancer
  JOURNAL   Oncogene 41 (18), 2555-2570 (2022)
   PUBMED   35318441
  REMARK    GeneRIF: USP49 mediates tumor progression and poor prognosis
            through a YAP1-dependent feedback loop in gastric cancer.
REFERENCE   5  (bases 1 to 8940)
  AUTHORS   Shi,L., Shen,X. and Shen,Y.
  TITLE     USP49-Mediated Histone H2B Deubiquitination Regulates HCT116 Cell
            Proliferation through MDM2-p53 Axis
  JOURNAL   Mol Cell Biol 42 (3), e0043421 (2022)
   PUBMED   35072515
  REMARK    GeneRIF: USP49-Mediated Histone H2B Deubiquitination Regulates
            HCT116 Cell Proliferation through MDM2-p53 Axis.
            Erratum:[Mol Cell Biol. 2022 Jun 16;42(6):e0013922. doi:
            10.1128/mcb.00139-22.. PMID: 35546121]
REFERENCE   6  (bases 1 to 8940)
  AUTHORS   Kamatani,Y., Matsuda,K., Okada,Y., Kubo,M., Hosono,N., Daigo,Y.,
            Nakamura,Y. and Kamatani,N.
  TITLE     Genome-wide association study of hematological and biochemical
            traits in a Japanese population
  JOURNAL   Nat Genet 42 (3), 210-215 (2010)
   PUBMED   20139978
REFERENCE   7  (bases 1 to 8940)
  AUTHORS   Sowa,M.E., Bennett,E.J., Gygi,S.P. and Harper,J.W.
  TITLE     Defining the human deubiquitinating enzyme interaction landscape
  JOURNAL   Cell 138 (2), 389-403 (2009)
   PUBMED   19615732
REFERENCE   8  (bases 1 to 8940)
  AUTHORS   Quesada,V., Diaz-Perales,A., Gutierrez-Fernandez,A., Garabaya,C.,
            Cal,S. and Lopez-Otin,C.
  TITLE     Cloning and enzymatic analysis of 22 novel human ubiquitin-specific
            proteases
  JOURNAL   Biochem Biophys Res Commun 314 (1), 54-62 (2004)
   PUBMED   14715245
REFERENCE   9  (bases 1 to 8940)
  AUTHORS   Sato,S., Tomomori-Sato,C., Banks,C.A., Parmely,T.J., Sorokina,I.,
            Brower,C.S., Conaway,R.C. and Conaway,J.W.
  TITLE     A mammalian homolog of Drosophila melanogaster transcriptional
            coactivator intersex is a subunit of the mammalian Mediator complex
  JOURNAL   J Biol Chem 278 (50), 49671-49674 (2003)
   PUBMED   14576168
REFERENCE   10 (bases 1 to 8940)
  AUTHORS   Sato,S., Tomomori-Sato,C., Banks,C.A., Sorokina,I., Parmely,T.J.,
            Kong,S.E., Jin,J., Cai,Y., Lane,W.S., Brower,C.S., Conaway,R.C. and
            Conaway,J.W.
  TITLE     Identification of mammalian Mediator subunits with similarities to
            yeast Mediator subunits Srb5, Srb6, Med11, and Rox3
  JOURNAL   J Biol Chem 278 (17), 15123-15127 (2003)
   PUBMED   12584197
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL160163.24 and AL365205.35.
            
            On Jun 20, 2020 this sequence version replaced NM_001286554.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038194.3945750.1,
                                           SRR14372079.2797058.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA2144120
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000682992.1/ ENSP00000507239.1
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-52                AL160163.24        60897-60948         c
            53-134              AL160163.24        57367-57448         c
            135-208             AL160163.24        37137-37210         c
            209-1592            AL365205.35        75912-77295         c
            1593-1797           AL365205.35        74090-74294         c
            1798-1906           AL365205.35        70114-70222         c
            1907-2112           AL365205.35        69008-69213         c
            2113-8940           AL365205.35        60180-67007         c
FEATURES             Location/Qualifiers
     source          1..8940
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6p21.1"
     gene            1..8940
                     /gene="USP49"
                     /note="ubiquitin specific peptidase 49"
                     /db_xref="GeneID:25862"
                     /db_xref="HGNC:HGNC:20078"
     exon            1..52
                     /gene="USP49"
                     /inference="alignment:Splign:2.1.0"
     exon            53..134
                     /gene="USP49"
                     /inference="alignment:Splign:2.1.0"
     exon            135..208
                     /gene="USP49"
                     /inference="alignment:Splign:2.1.0"
     exon            209..1592
                     /gene="USP49"
                     /inference="alignment:Splign:2.1.0"
     CDS             237..2303
                     /gene="USP49"
                     /EC_number="3.4.19.12"
                     /note="isoform a is encoded by transcript variant 1;
                     ubiquitin specific protease 49; deubiquitinating enzyme
                     49; ubiquitin-specific-processing protease 49; ubiquitin
                     carboxyl-terminal hydrolase 49; ubiquitin thioesterase 49;
                     ubiquitin thiolesterase 49"
                     /codon_start=1
                     /product="ubiquitin carboxyl-terminal hydrolase 49 isoform
                     a"
                     /protein_id="NP_001273483.1"
                     /db_xref="CCDS:CCDS69111.1"
                     /db_xref="GeneID:25862"
                     /db_xref="HGNC:HGNC:20078"
                     /translation="MDRCKHVGRLRLAQDHSILNPQKWCCLECATTESVWACLKCSHV
                     ACGRYIEDHALKHFEETGHPLAMEVRDLYVFCYLCKDYVLNDNPEGDLKLLRSSLLAV
                     RGQKQDTPVRRGRTLRSMASGEDVVLPQRAPQGQPQMLTALWYRRQRLLARTLRLWFE
                     KSSRGQAKLEQRRQEEALERKKEEARRRRREVKRRLLEELASTPPRKSARLLLHTPRD
                     AGPAASRPAALPTSRRVPAATLKLRRQPAMAPGVTGLRNLGNTCYMNSILQVLSHLQK
                     FRECFLNLDPSKTEHLFPKATNGKTQLSGKPTNSSATELSLRNDRAEACEREGFCWNG
                     RASISRSLELIQNKEPSSKHISLCRELHTLFRVMWSGKWALVSPFAMLHSVWSLIPAF
                     RGYDQQDAQEFLCELLHKVQQELESEGTTRRILIPFSQRKLTKQVLKVVNTIFHGQLL
                     SQVTCISCNYKSNTIEPFWDLSLEFPERYHCIEKGFVPLNQTECLLTEMLAKFTETEA
                     LEGRIYACDQCNSKRRKSNPKPLVLSEARKQLMIYRLPQVLRLHLKRFRWSGRNHREK
                     IGVHVVFDQVLTMEPYCCRDMLSSLDKETFAYDLSAVVMHHGKGFGSGHYTAYCYNTE
                     GGFWVHCNDSKLNVCSVEEVCKTQAYILFYTQRTVQGNARISETHLQAQVQSSNNDEG
                     RPQTFS"
     exon            1593..1797
                     /gene="USP49"
                     /inference="alignment:Splign:2.1.0"
     exon            1798..1906
                     /gene="USP49"
                     /inference="alignment:Splign:2.1.0"
     exon            1907..2112
                     /gene="USP49"
                     /inference="alignment:Splign:2.1.0"
     exon            2113..8940
                     /gene="USP49"
                     /inference="alignment:Splign:2.1.0"
     regulatory      8922..8927
                     /regulatory_class="polyA_signal_sequence"
                     /gene="USP49"
                     /note="hexamer: ATTAAA"
     polyA_site      8940
                     /gene="USP49"
                     /note="major polyA site"
ORIGIN      
        1 gtgttcggtt gtctcgcgcc ctggtgacag ctcgcgcgtg ctgatgatgg cgattctttg
       61 gatgggaaga gaccttgaaa ggacctctag tttatcctgc aactccagtc aatatcccac
      121 ttaaatcatt ccaggtaata gagaagagga aacctaacca atgactgtgg aataatatgg
      181 aagaagatgg aaaaaacttg tttaatgggt tgagaaagtg gcgacttcta taagacatgg
      241 atagatgcaa acatgtaggg cggttacggc tcgcccagga ccactccatc ctgaaccctc
      301 agaagtggtg ctgcttagag tgtgccacca ccgagtccgt gtgggcctgc ctcaagtgct
      361 cccacgtggc ctgcggccgc tatattgagg accacgccct gaaacacttt gaggagacgg
      421 gacacccgct agccatggaa gtccgggatc tctacgtgtt ctgttacctg tgcaaggact
      481 acgtgctcaa tgataaccca gagggggacc tgaagctgct aagaagctcc ctcctggcgg
      541 tccggggcca gaaacaggac acgccggtga gacgtgggcg gacgctgcgg tccatggctt
      601 cgggtgagga cgtggtcctg ccgcagcgcg ctcctcaggg acagccgcag atgctcacgg
      661 ctctgtggta ccggcgtcag cgcctgctgg ccaggacgct gcggctgtgg ttcgagaaga
      721 gctcccgggg ccaggcgaag ctggagcagc ggcggcagga ggaggccctg gagcgcaaga
      781 aggaggaggc gcggaggcgg cggcgcgagg tgaaacggcg gctgctggag gagctggcca
      841 gcacccctcc gcgcaagagt gcacggctgc tcctgcacac gccccgcgac gcgggcccgg
      901 ctgcctcgcg ccccgccgcc ctccctacct cacgcagagt gcccgccgcc acactcaagc
      961 tgcgtcgcca gccggccatg gccccaggcg tcacgggcct gcgcaacctg ggcaacacct
     1021 gctacatgaa ctccatcctc caggtgctca gccacctcca gaagttccga gaatgtttcc
     1081 tcaaccttga cccttccaaa acggaacatc tgtttcccaa agccaccaac gggaagactc
     1141 agctttctgg caagccaacc aacagctcgg ccacggagct gtccttgaga aatgacaggg
     1201 ccgaggcatg cgagcgggag ggcttctgct ggaacggcag ggcctccatt agtcggagtc
     1261 tggagctcat ccagaacaag gagccgagtt caaagcacat ttccctctgc cgtgaactgc
     1321 acaccctctt ccgagtcatg tggtccggga agtgggccct agtgtcgccc ttcgccatgc
     1381 tccactcagt gtggagcctg atccctgcct tccgcggcta cgaccaacag gacgcgcagg
     1441 aatttctctg cgagctgctg cacaaggtgc agcaggaact cgagtctgag ggcaccacac
     1501 gccggatcct catccccttc tcccagagga agctcaccaa acaggtctta aaggtggtga
     1561 ataccatatt tcatgggcag ctgctcagtc aggtcacatg tatatcatgc aattacaaat
     1621 ccaataccat tgagcccttt tgggacctat ccctggaatt ccctgaacgc tatcactgca
     1681 tagaaaaggg gtttgtccct ttgaatcaaa cagagtgctt gctcactgag atgctggcca
     1741 aattcacaga gacagaggcc ctggaaggga gaatctacgc ttgtgaccag tgtaacagca
     1801 aacgacgaaa atccaatccc aaaccccttg ttctgagtga agctagaaag cagttaatga
     1861 tctacagact acctcaggtt ctccggctgc accttaaaag attcaggtgg tctggccgta
     1921 atcatcgaga gaagattggg gtccatgtcg tctttgacca ggtattaacc atggaacctt
     1981 actgctgcag ggacatgctc tcctctcttg acaaagagac ctttgcctat gatctctccg
     2041 cagtggtcat gcatcacggg aaagggtttg gctcaggaca ctacacagcc tattgctaca
     2101 acacagaggg aggtttttgg gtccactgca atgactcaaa gctgaatgta tgcagtgtcg
     2161 aggaagtgtg caaaacccag gcctacatcc ttttttacac tcaaagaaca gtgcagggca
     2221 atgcaagaat ctcagaaacc catctccaag ctcaggtgca gtccagcaac aatgatgaag
     2281 gcagaccaca gacattttcc tgaatgggag gcatgtatca aagactggct tttgtgtatt
     2341 ggtgtccata catctttcct cttataggaa ataaggctac tgcaggaaca gattactagg
     2401 tttgccttgc tgggtctaga gtagaaggtg ccaggtgatt cgtgtcctgt cgtaaatttt
     2461 atagtctctt tcttttgaat gagtttggga gttccctcct ttcctaaaaa caaaagaagt
     2521 aacttctatg aagatccttt catcagttgc ttctgaatat agagggatct gggtggagga
     2581 aagcggggcg ggggggtaaa tcaatcatat ccacacagga gagcagccat gttttctctc
     2641 catgatgtga ttcccctgct aatcaggacc tccttgcagc accagaagaa ccctccggat
     2701 gtgagcagtc ctggacagag cacgtgagga ggggccctgg gctagcagtt tgctggatgg
     2761 gattggctcc aagatgggag atgaagtcta aagggtttat tcccacaaag gaagtaacct
     2821 tcaagggttt aaaacaaact tccttttttg gggatagcag ctgaagagtg gagtgagatg
     2881 catggaacaa atttccccat gcaaagtggg atggttttca tatgtcatac cctccctact
     2941 tgctgctgtc atataatcat tccatacttc tgagactggc atgaataccc cttcattcta
     3001 aagaaggggc aggtcatata aagaagcaat agactagcac atgttccatg ctgagccaaa
     3061 ggacactcct ggctatctca gttctgtagc agatccctgg ttcaggtcta gggcaagcac
     3121 atggtttggt ttaaattgat tcttaggttt tctcagaact caattgaggg tgggcagaga
     3181 tagctgatgc tccagggctt attgaaggcc tgtcacccgt tctcacttca gtgcggcatg
     3241 cagcttctta gcctgcagct tctttcttgc tcctggagag ctagaacatt catgttcaca
     3301 gggtttggga gcttttggtt ctctagggta tgttaactgc ttaggagtcc acctcgtaca
     3361 tatctgaaga gttgattacc aatggccttg acctgtttcc tcccaaatct gataatccct
     3421 actgttgctt taccccccat actcagtcca tcagagaaaa aaacaagagt gccccgtcct
     3481 ttcccccagt gctagtaaaa tacatcttcc tttttaaatt gggtcagttt ctaaacagaa
     3541 tgaaattgcc cagataaaaa cccttgtccc catcaggcac cacttcattc ttagttcttc
     3601 acttagattt gctggtgaaa gtgaatgcaa accctaactt ttgttgctgt ggtcactgca
     3661 gtgagcctca ctcaacctgt cactatgaat gctcatcttt tgactgagta tatcatatta
     3721 atgtttgaat tcaggtagaa gtacagttgt cacttgaagg gagtagatgt ggaagggcgt
     3781 tcggggagga gtgggaagtg gggaaagcca ggctaaagaa tgagggttat agctttagca
     3841 atgttgatga gccacatttc ccacacagat ctgtagcatt tgctgttgac ctcttttgag
     3901 atgaactctc ccataggccc tgccaggcag cactgagaca tggaggaaat tcagacaaaa
     3961 aatggctcac cctgataggg aaggagtgac tatattttaa attaaacttg ctttttccaa
     4021 cactgtgagg tttctgtaat atttagcttt tatttggaag cgatagcgta tggcattttt
     4081 tatgctgttt ggtttatatt gtctactgca ggcttctttg tataagcttt gcctgggctc
     4141 accctctcct ggacactgtt ttaaagtgtc accgctgtcc atgctgccag aggctctgat
     4201 gtgaagctgt actctcaaga tccacgtttt taagtcggca tgattagtaa tgactttttg
     4261 tggcaataga aaagcccatt aactcaaaaa aaccaaggag agtaaaaagg aaaggaaact
     4321 atgaatcgtg cctcatcttt cattgaatcc tatatttatt attctagaaa aaaagaactt
     4381 acaagataga gaagaactaa tagagcatct actttacccc tcaggctgtc cagtggggat
     4441 aattattaat aaacatttaa tggaaaattc aaagatcttc caatttaatt tttaaaaata
     4501 gttttatacc aaatattata aggatttatt aagcagatta aggactttgt gaaataagtg
     4561 cttaacttag ctgagcacgc atatatcaaa gtaataaaag aaactaacat cagagtctcc
     4621 actgagctac acatttgtga aaggtgccca ctgcagttac agacacctca ggtacccaga
     4681 ggcggcagca ctggacactt aggacgttag tatttaagga gatttttatt aaagaagagt
     4741 tccctgctgc ataagccaat ggctattgtg agggaaatgt ccctttgcct ttaatttatt
     4801 tacgtactgg gtatagatga atgtctcagt tgcatctgaa attgaatcat tctaaagaga
     4861 agaaaataag aaccaggtaa aaactgacta gatgctgcca aatcaaaccc aaggtctcct
     4921 aaccgaacct taatgggcct gcttctctcc cagggcaagt agttaagagt ctcattccag
     4981 gaaccctttg tagttagttg gctggcatgt ttacttgctg ctgtagccag ccaagatgag
     5041 tgcacctagg ccctcaaaaa ggattttttt ttacctcaat ctagcctgac cctcatatct
     5101 gtggttgcct ctgagacgaa catccatgct agtataaaaa tagttaggaa tgcccttggc
     5161 agaactgaag ctcttattaa atggtggaca gagctcttgc cagctttgat ccagcccctc
     5221 agtctcggag ttatggggca gggttggggg gcagtgctac actgtaaaga atttccaggc
     5281 tgggcgcggt ggctcatgcc tgtaatccca gcactttggg aggccgagga gggcggatca
     5341 caaggtcaag agattgagat catcctggcc aacatggtga aactccgtct ctactaaaaa
     5401 tacaaaaatt agctgggcat ggtggcacgt gcctgtagtc ccagctactt gggaggctga
     5461 ggcaggagaa tcgctggaac ccaggaggca gaaggggcag tgagccgaga tcgtgccact
     5521 gcactccagc ctggcgacag agcgagactc tgtcttaaaa aaaaaacaaa aacaaaaaca
     5581 aaaaaaaaaa aagaatttcc agatgtctct taaaatgtca tgaataaaat tggaaactgt
     5641 agaagtgtta atgtgtccta tggactcaat agcagagttt atttttgttt ttaatggcaa
     5701 ggcttctaga gtcaatgatt gtatgagttt gctactctgg ctgtgcttac agcttcatcc
     5761 aagtacaagg gaagaaccaa tgaggtggat tggctgacag tggggcatgc cccagcataa
     5821 gccctagaga ggtcgacagt agtgcagaat gaaaacttgg tcggggatgg cgggtggtgg
     5881 gtgggaggag ggtgggctgg ccgggaggga gaaatggagt ttgttctact tactgataaa
     5941 gctttgtgaa ctaattttat acaattcata aaatttggtg ccttgtactc aattacggtt
     6001 tgcatggaat tgaaaagatt aagggaaagg atttcttctt gtcatttcaa gtggcaaatg
     6061 ggtctgtgta gtgtttaaag gacatctggt atcacagact tttaaaaagc atttcatgtc
     6121 tcttgtgtgt gaatgcaaat tattcttacc agcaagttct gaaattatgt tacaatgtcc
     6181 aaattctttg tatttgtgac tgttcatcaa atggctgctt ttcaaggcag actgtgtact
     6241 ccattgtttt tcacttccct tgtcatgttc catacattga cttgggcctt tttaaatcag
     6301 gctggggggc taccccttct taaatgaata ctatatccct atctgaggtt acctcttgtg
     6361 agtggaaggg ttgctttccc aggtggttgg gagagcacaa atgttgagaa aaggcctttt
     6421 agtctttatc aaaacaatga ctaatgctgg gcaacatata gcagaagtca aacaaaaatg
     6481 attcctcctg aaatggtacc ttcattggtt ctgatgttct tttgcaaaaa atgtccggaa
     6541 gcagtataga aaaccccctg tatgtgaacc ttagattgta aggcaagcca gtgcactgtg
     6601 taatatgcaa agggagtggt gcaaaagaga aggcacccgt cccagctctc catgcccttt
     6661 ccctggcagg cgctgactga gatggcgctg agtgaatgtg gaaggtgcta agacccagtc
     6721 tcttcactgc agggctgttt acagccagtt tcttttactc tgaccttaag gtttccactg
     6781 agctcatgaa acttcaacat atggtgttta aaagtttccc actcaaatgc acacttgaaa
     6841 attgggtccc tcagcctcat tactgaacta aataagtgaa gaagttgtat ctttggggta
     6901 aaactttcca gggccactta attttttaac cagttaagta cgcatcttcc tggtggttca
     6961 gactttttaa gtcagtgcta aagctgaaaa gcgccttcta aatatgactg tgagtttagt
     7021 ttgtatctta catttagtaa ctgttctgtt gggccaggac tatgacttta attactatgt
     7081 acttattcat cccacactct gcactaaata caccatagct actatagcat tgtggcaggc
     7141 actcattttt gtggactcat tccatacttc tgctggcata tttcgtttaa aatctagcta
     7201 aagattttca tagtactgtg ttaactagcc agggctgaaa agtgtgacag gatatcaaat
     7261 tgactttcct tggggaaaat gttgctttgg caatagtgaa gtccaactcc ttcatttaca
     7321 gaattagtga ttactcatca atttttgaaa gttgtagatt aagtagtttt atttactaaa
     7381 ttcttaacca ctttgaagat ttaagccagt tgaaatgaaa cattggctgg atgcagttgg
     7441 ctagcacctg taatcccaac actttgggag gccaaggtgg gaggattgct tgaggccagg
     7501 agctcaagac cagcctggga aacatagatt tgaaatcttt tcaaaaatgt ataaaaattt
     7561 aataaataaa taaatgaatc cttactcaac cataattatg gctttaaaac ccaaccaaca
     7621 gtaaacactt acttgaagcc aaaacagtaa attttgaatg aaatttgaat tatgcttttg
     7681 gaagctgcca tgtcttaatt cttgctggat tttgattttc aattttggaa gtttttatca
     7741 aaactgtcca gtcatgagta tatcaggtag cagcctttaa ggatctaagt ttcattccta
     7801 taaagaacag gaggtgctgg tatttcttgt cttagcaagt gatctgatgc aggtctaaat
     7861 gggggttagc atctatacta tggcttaaaa gtttcctcct tggtcaccat ttgggaggtg
     7921 atggcttcaa agctaagctt tgctctcatg tgacccttct ttatcttaat acccaataag
     7981 atataaacct ctcagagtca acccagtgta gactcaaagg gtcttagctt catctatcag
     8041 ataagatcta tctgatttat acaaagaatg gtgctgtttt tatatacata ctaaaaaaat
     8101 ctaattctca aacaattttc ttaatattta tgccagcaag gtcaggaaag actattttgt
     8161 cctgtttaac tttagtagtg aacaaactgc tagagacatc tgtcatcctt aacaggccac
     8221 tgtggtcctt atatactgac cctcctttcc aattaacgtc ctttaatccc atactagttc
     8281 cataagagac ttggcacata aaagcagtat tttttttaat gcctagtaaa ctggccagaa
     8341 aaaaatattg ccatggtgga cctgtttcta tccacctctt tctatggcta tataagtcta
     8401 tacatgccag ttccgtacat actccatttc caaagagccc ccaaaccctg gacagtagca
     8461 ctaccatgaa ttttagggtc acaaaacatt tccttctgaa ggaagcagct gcctcagcag
     8521 tgtcacttta gtgaccactg cccaggctta cttcactttg cctcccccta cacatcactg
     8581 ccctctttct gccaccaaac ctcactattc cagcaatgat gcctccctgg tgtctggaaa
     8641 acccatctgg tgcactaaaa tgctatgcaa caccaaatgg cttcttcccc taatattgct
     8701 caacaatgta aattcttcaa gaataaactt catgctaggt taacatcaat gtatggttac
     8761 agcttccttt tttttttttc ccttttaaaa tgaagcaaac cacctccatt aaaatccatg
     8821 ttttggggct tgtttttgtc tctcaagtgt gaaatataaa tcatgttttt atgatttttg
     8881 taaatctttt tacaccttgt ttttgtaagc aaaagtttct tattaaaaga ataaaatgac
//
