LOCUS       NM_001372103           10062 bp    mRNA    linear   PRI 09-JUN-2024
DEFINITION  Homo sapiens ubiquitin specific peptidase 47 (USP47), transcript
            variant 14, mRNA.
ACCESSION   NM_001372103
VERSION     NM_001372103.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 10062)
  AUTHORS   Lei,H., Xu,H., Yang,L., Wang,Y., Zhang,Y. and Wu,Y.
  TITLE     USP47 stabilizes YBX1 to promote the progression of acute myeloid
            leukemia
  JOURNAL   Oncogene 43 (7), 539-542 (2024)
   PUBMED   38104157
  REMARK    GeneRIF: USP47 stabilizes YBX1 to promote the progression of acute
            myeloid leukemia.
REFERENCE   2  (bases 1 to 10062)
  AUTHORS   Wang,A., Huang,H., Shi,J.H., Yu,X., Ding,R., Zhang,Y., Han,Q.,
            Ni,Z.Y., Li,X., Zhao,R. and Zou,Q.
  TITLE     USP47 inhibits m6A-dependent c-Myc translation to maintain
            regulatory T cell metabolic and functional homeostasis
  JOURNAL   J Clin Invest 133 (23), e169365 (2023)
   PUBMED   37788092
  REMARK    GeneRIF: USP47 inhibits m6A-dependent c-Myc translation to maintain
            regulatory T cell metabolic and functional homeostasis.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 10062)
  AUTHORS   Shin,S.C., Park,J., Kim,K.H., Yoon,J.M., Cho,J., Ha,B.H., Oh,Y.,
            Choo,H., Song,E.J. and Kim,E.E.
  TITLE     Structural and functional characterization of USP47 reveals a hot
            spot for inhibitor design
  JOURNAL   Commun Biol 6 (1), 970 (2023)
   PUBMED   37740002
  REMARK    GeneRIF: Structural and functional characterization of USP47
            reveals a hot spot for inhibitor design.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 10062)
  AUTHORS   Chen,H.Y., Tang,R.C., Liang,J.W., Zhao,W., Yu,S.S., Yao,R.R.,
            Xu,R., Zhang,A., Geng,S., Sun,X.Y., Ge,Q. and Zhang,J.
  TITLE     Deubiquitinase USP47 attenuates virus-induced type I interferon
            signaling
  JOURNAL   Int Immunopharmacol 118, 110040 (2023)
   PUBMED   37001379
  REMARK    GeneRIF: Deubiquitinase USP47 attenuates virus-induced type I
            interferon signaling.
REFERENCE   5  (bases 1 to 10062)
  AUTHORS   Kassel,S., Hanson,A.J., Benchabane,H., Saito-Diaz,K., Cabel,C.R.,
            Goldsmith,L., Taha,M., Kanuganti,A., Ng,V.H., Xu,G., Ye,F.,
            Picker,J., Port,F., Boutros,M., Weiss,V.L., Robbins,D.J.,
            Thorne,C.A., Ahmed,Y. and Lee,E.
  TITLE     USP47 deubiquitylates Groucho/TLE to promote Wnt-beta-catenin
            signaling
  JOURNAL   Sci Signal 16 (771), eabn8372 (2023)
   PUBMED   36749823
  REMARK    GeneRIF: USP47 deubiquitylates Groucho/TLE to promote
            Wnt-beta-catenin signaling.
REFERENCE   6  (bases 1 to 10062)
  AUTHORS   Yang,S.W., Oh,K.H., Park,E., Chang,H.M., Park,J.M., Seong,M.W.,
            Ka,S.H., Song,W.K., Park,D.E., Baas,P.W., Jeon,Y.J. and Chung,C.H.
  TITLE     USP47 and C terminus of Hsp70-interacting protein (CHIP)
            antagonistically regulate katanin-p60-mediated axonal growth
  JOURNAL   J Neurosci 33 (31), 12728-12738 (2013)
   PUBMED   23904609
  REMARK    GeneRIF: The results of this study indicated that USP47 plays a
            crucial role in the control of axonal growth during neuronal
            development by antagonizing CHIP-mediated katanin-p60 degradation.
REFERENCE   7  (bases 1 to 10062)
  AUTHORS   Parsons,J.L., Dianova,I.I., Khoronenkova,S.V., Edelmann,M.J.,
            Kessler,B.M. and Dianov,G.L.
  TITLE     USP47 is a deubiquitylating enzyme that regulates base excision
            repair by controlling steady-state levels of DNA polymerase beta
  JOURNAL   Mol Cell 41 (5), 609-615 (2011)
   PUBMED   21362556
  REMARK    GeneRIF: USP47 has a role in regulating DNA repair and maintaining
            genome integrity
REFERENCE   8  (bases 1 to 10062)
  AUTHORS   Peschiaroli,A., Skaar,J.R., Pagano,M. and Melino,G.
  TITLE     The ubiquitin-specific protease USP47 is a novel beta-TRCP
            interactor regulating cell survival
  JOURNAL   Oncogene 29 (9), 1384-1393 (2010)
   PUBMED   19966869
  REMARK    GeneRIF: USP47, a novel beta-Trcp interactor, regulates cell growth
            and survival, potentially providing a novel target for anticancer
            therapies.
REFERENCE   9  (bases 1 to 10062)
  AUTHORS   Quesada,V., Diaz-Perales,A., Gutierrez-Fernandez,A., Garabaya,C.,
            Cal,S. and Lopez-Otin,C.
  TITLE     Cloning and enzymatic analysis of 22 novel human ubiquitin-specific
            proteases
  JOURNAL   Biochem Biophys Res Commun 314 (1), 54-62 (2004)
   PUBMED   14715245
REFERENCE   10 (bases 1 to 10062)
  AUTHORS   Puente,X.S., Sanchez,L.M., Overall,C.M. and Lopez-Otin,C.
  TITLE     Human and mouse proteases: a comparative genomic approach
  JOURNAL   Nat Rev Genet 4 (7), 544-558 (2003)
   PUBMED   12838346
  REMARK    Review article
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC104383.4 and AC124276.5.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803611.233757.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA2153932
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-253               AC104383.4         64816-65068
            254-369             AC104383.4         96644-96759
            370-573             AC104383.4         103021-103224
            574-687             AC104383.4         107311-107424
            688-826             AC104383.4         114812-114950
            827-923             AC124276.5         194177-194273       c
            924-1069            AC124276.5         189010-189155       c
            1070-1149           AC124276.5         188528-188607       c
            1150-1299           AC124276.5         186322-186471       c
            1300-1395           AC124276.5         171619-171714       c
            1396-1548           AC124276.5         171376-171528       c
            1549-1716           AC124276.5         168979-169146       c
            1717-1848           AC124276.5         162305-162436       c
            1849-1925           AC124276.5         161750-161826       c
            1926-1981           AC124276.5         161119-161174       c
            1982-2094           AC124276.5         158754-158866       c
            2095-2199           AC124276.5         157935-158039       c
            2200-2407           AC124276.5         155360-155567       c
            2408-2523           AC124276.5         153498-153613       c
            2524-2643           AC124276.5         151322-151441       c
            2644-3421           AC124276.5         148758-149535       c
            3422-3597           AC124276.5         143750-143925       c
            3598-3678           AC124276.5         143312-143392       c
            3679-3794           AC124276.5         141866-141981       c
            3795-3913           AC124276.5         141388-141506       c
            3914-4044           AC124276.5         138999-139129       c
            4045-4175           AC124276.5         136706-136836       c
            4176-10062          AC124276.5         129983-135869       c
FEATURES             Location/Qualifiers
     source          1..10062
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11p15.3"
     gene            1..10062
                     /gene="USP47"
                     /gene_synonym="TRFP"
                     /note="ubiquitin specific peptidase 47"
                     /db_xref="GeneID:55031"
                     /db_xref="HGNC:HGNC:20076"
                     /db_xref="MIM:614460"
     exon            1..253
                     /gene="USP47"
                     /gene_synonym="TRFP"
                     /inference="alignment:Splign:2.1.0"
     exon            254..369
                     /gene="USP47"
                     /gene_synonym="TRFP"
                     /inference="alignment:Splign:2.1.0"
     exon            370..573
                     /gene="USP47"
                     /gene_synonym="TRFP"
                     /inference="alignment:Splign:2.1.0"
     CDS             571..4350
                     /gene="USP47"
                     /gene_synonym="TRFP"
                     /EC_number="3.4.19.12"
                     /note="isoform m is encoded by transcript variant 14;
                     ubiquitin carboxyl-terminal hydrolase 47; ubiquitin
                     thioesterase 47; deubiquitinating enzyme 47;
                     ubiquitin-specific-processing protease 47; ubiquitin
                     thiolesterase 47; Trf (TATA binding protein-related
                     factor)-proximal homolog"
                     /codon_start=1
                     /product="ubiquitin carboxyl-terminal hydrolase 47 isoform
                     m"
                     /protein_id="NP_001359032.1"
                     /db_xref="GeneID:55031"
                     /db_xref="HGNC:HGNC:20076"
                     /db_xref="MIM:614460"
                     /translation="MAPLDHTSDKSLLDANFEPGKKNFLHLTDKDGEQPQILLEDSSA
                     GEDSVHDRFIGPLPREGSGGSTSDYVSQSYSYSSILNKSETGYVGLVNQAMTCYLNSL
                     LQTLFMTPEFRNALYKWEFEESEEDPVTSIPYQLQRLFVLLQTSKKRAIETTDVTRSF
                     GWDSSEAWQQHDVQELCRVMFDALEQKWKQTEQADLINELYQGKLKDYVRCLECGYEG
                     WRIDTYLDIPLVIRPYGSSQAFASVEEALHAFIQPEILDGPNQYFCERCKKKCDARKG
                     LRFLHFPYLLTLQLKRFDFDYTTMHRIKLNDRMTFPEELDMSTFIDVEDEKSPQTESC
                     TDSGAENEGSCHSDQMSNDFSNDDGVDEGICLETNSGTEKISKSGLEKNSLIYELFSV
                     MVHSGSAAGGHYYACIKSFSDEQWYSFNDQHVSRITQEDIKKTHGGSSGSRGYYSSAF
                     ASSTNAYMLIYRLKDPARNAKFLEVDEYPEHIKNLVQKERELEEQEKRQREIERNTCK
                     IKLFCLHPTKQVMMENKLEVHKDKTLKEAVEMAYKMMDLEEVIPLDCCRLVKYDEFHD
                     YLERSYEGEEDTPMGLLLGGVKSTYMFDLLLETRKPDQVFQSYKPGEVMVKVHVVDLK
                     AESVAAPITVRAYLNQTVTEFKQLISKAIHLPAETMRIVLERCYNDLRLLSVSSKTLK
                     AEGFFRSNKVFVESSETLDYQMAFADSHLWKLLDRHANTIRLFVLLPEQSPVSYSKRT
                     AYQKAGGDSGNVDDDCERVKGPVGSLKSVEAILEESTEKLKSLSLQQQQDGDNGDSSK
                     STETSDFENIESPLNERDSSASVDNRELEQHIQTSDPENFQSEERSDSDVNNDRSTSS
                     VDSDILSSSHSSDTLCNADNAQIPLANGLDSHSITSSRRTKANEGKKETWDTAEEDSG
                     TDSEYDESGKSRGEMQYMYFKAEPYAADEGSGEGHKWLMVHVDKRITLAAFKQHLEPF
                     VGVLSSHFKVFRVYASNQEFESVRLNETLSSFSDDNKITIRLGRALKKGEYRVKVYQL
                     LVNEQEPCKFLLDAVFAKGMTVRQSKEELIPQLREQCGLELSIDRFRLRKKTWKNPGT
                     VFLDYHIYEEDINISSNWEVFLEVLDGVEKMKSMSQLAVLSRRWKPSEMKLDPFQEVV
                     LESSSVDELREKGRGTFPCDISVLDIHQDLDWNPKVSTLNVWPLYICDDGAVIFYRDK
                     TEELMELTDEQRNELMKKESSRLQKTGHRVTYSPRKEKALKIYLDGAPNKDLTQD"
     exon            574..687
                     /gene="USP47"
                     /gene_synonym="TRFP"
                     /inference="alignment:Splign:2.1.0"
     exon            688..826
                     /gene="USP47"
                     /gene_synonym="TRFP"
                     /inference="alignment:Splign:2.1.0"
     exon            827..923
                     /gene="USP47"
                     /gene_synonym="TRFP"
                     /inference="alignment:Splign:2.1.0"
     exon            924..1069
                     /gene="USP47"
                     /gene_synonym="TRFP"
                     /inference="alignment:Splign:2.1.0"
     exon            1070..1149
                     /gene="USP47"
                     /gene_synonym="TRFP"
                     /inference="alignment:Splign:2.1.0"
     exon            1150..1299
                     /gene="USP47"
                     /gene_synonym="TRFP"
                     /inference="alignment:Splign:2.1.0"
     exon            1300..1395
                     /gene="USP47"
                     /gene_synonym="TRFP"
                     /inference="alignment:Splign:2.1.0"
     exon            1396..1548
                     /gene="USP47"
                     /gene_synonym="TRFP"
                     /inference="alignment:Splign:2.1.0"
     exon            1549..1716
                     /gene="USP47"
                     /gene_synonym="TRFP"
                     /inference="alignment:Splign:2.1.0"
     exon            1717..1848
                     /gene="USP47"
                     /gene_synonym="TRFP"
                     /inference="alignment:Splign:2.1.0"
     exon            1849..1925
                     /gene="USP47"
                     /gene_synonym="TRFP"
                     /inference="alignment:Splign:2.1.0"
     exon            1926..1981
                     /gene="USP47"
                     /gene_synonym="TRFP"
                     /inference="alignment:Splign:2.1.0"
     exon            1982..2094
                     /gene="USP47"
                     /gene_synonym="TRFP"
                     /inference="alignment:Splign:2.1.0"
     exon            2095..2199
                     /gene="USP47"
                     /gene_synonym="TRFP"
                     /inference="alignment:Splign:2.1.0"
     exon            2200..2407
                     /gene="USP47"
                     /gene_synonym="TRFP"
                     /inference="alignment:Splign:2.1.0"
     exon            2408..2523
                     /gene="USP47"
                     /gene_synonym="TRFP"
                     /inference="alignment:Splign:2.1.0"
     exon            2524..2643
                     /gene="USP47"
                     /gene_synonym="TRFP"
                     /inference="alignment:Splign:2.1.0"
     exon            2644..3421
                     /gene="USP47"
                     /gene_synonym="TRFP"
                     /inference="alignment:Splign:2.1.0"
     exon            3422..3597
                     /gene="USP47"
                     /gene_synonym="TRFP"
                     /inference="alignment:Splign:2.1.0"
     exon            3598..3678
                     /gene="USP47"
                     /gene_synonym="TRFP"
                     /inference="alignment:Splign:2.1.0"
     exon            3679..3794
                     /gene="USP47"
                     /gene_synonym="TRFP"
                     /inference="alignment:Splign:2.1.0"
     exon            3795..3913
                     /gene="USP47"
                     /gene_synonym="TRFP"
                     /inference="alignment:Splign:2.1.0"
     exon            3914..4044
                     /gene="USP47"
                     /gene_synonym="TRFP"
                     /inference="alignment:Splign:2.1.0"
     exon            4045..4175
                     /gene="USP47"
                     /gene_synonym="TRFP"
                     /inference="alignment:Splign:2.1.0"
     exon            4176..10062
                     /gene="USP47"
                     /gene_synonym="TRFP"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4724..4729
                     /regulatory_class="polyA_signal_sequence"
                     /gene="USP47"
                     /gene_synonym="TRFP"
                     /note="hexamer: AATAAA"
     polyA_site      4745
                     /gene="USP47"
                     /gene_synonym="TRFP"
                     /note="major polyA site"
     regulatory      5091..5096
                     /regulatory_class="polyA_signal_sequence"
                     /gene="USP47"
                     /gene_synonym="TRFP"
                     /note="hexamer: AATAAA"
     polyA_site      5120
                     /gene="USP47"
                     /gene_synonym="TRFP"
     regulatory      5671..5676
                     /regulatory_class="polyA_signal_sequence"
                     /gene="USP47"
                     /gene_synonym="TRFP"
                     /note="hexamer: AATAAA"
     polyA_site      5690
                     /gene="USP47"
                     /gene_synonym="TRFP"
     regulatory      7306..7311
                     /regulatory_class="polyA_signal_sequence"
                     /gene="USP47"
                     /gene_synonym="TRFP"
                     /note="hexamer: AATAAA"
     polyA_site      7329
                     /gene="USP47"
                     /gene_synonym="TRFP"
     regulatory      7480..7485
                     /regulatory_class="polyA_signal_sequence"
                     /gene="USP47"
                     /gene_synonym="TRFP"
                     /note="hexamer: AATAAA"
     polyA_site      7500
                     /gene="USP47"
                     /gene_synonym="TRFP"
ORIGIN      
        1 gacgaaggcg gctgtggtag cggcggcggc ggcggcggag ccctgggtcg gtgtctgcgc
       61 gctggtgtct gaggcccagg ctgaggcctc cgctattgct ggagcgcagg cggcggagag
      121 gatgactgcc gctgccattc tctcttgagc tagcgagccg ccgccaccct ccaccctccc
      181 ccggcagggc ggagaggagc ggccggagtc agcgatggtg cccggcgagg agaaccaact
      241 ggtcccgaaa gaggatgtgt tttggagatg cagacaaaat atctttgatg aaatgaagaa
      301 gaaattttta caggtagact gctgatgtaa ttgctttaat gtgataatca gcagagcaag
      361 taacagcata tagaaaatgc tgctgaagaa cctagagtct tatgtattat acaagatact
      421 actaattcaa agacagtgaa tgaacggatc actttaaatt taccagcatc tactccagtc
      481 agaaagctct ttgaagatgt ggccaacaaa gtaggctaca taaatggaac ctttgacttg
      541 gtgtggggaa atggaatcaa tactgctgat atggcaccac tggatcatac cagtgacaag
      601 tcacttctcg acgctaattt tgagccagga aagaagaact ttctgcattt gacagataaa
      661 gatggtgaac aacctcaaat actgctggag gattccagtg ctggggaaga cagtgttcat
      721 gacaggttta taggtccgct tccaagagaa ggttctgggg gttctaccag tgattatgtc
      781 agccaaagct actcctactc atctattttg aataaatcag aaactggata tgtgggacta
      841 gtaaaccaag caatgacttg ctatttgaat agccttttgc aaacactttt tatgactcct
      901 gaatttagga atgcattata taagtgggaa tttgaagaat ctgaagaaga tccagtgaca
      961 agtattccat accaacttca aaggcttttt gttttgttac aaaccagcaa aaagagagca
     1021 attgaaacca cagatgttac aaggagcttt ggatgggata gtagtgaggc ttggcagcag
     1081 catgatgtac aagaactatg cagagtcatg tttgatgctt tggaacagaa atggaagcaa
     1141 acagaacagg ctgatcttat aaatgagcta tatcaaggca agctgaagga ctacgtgaga
     1201 tgtctggaat gtggttatga gggctggcga atcgacacat atcttgatat tccattggtc
     1261 atccgacctt atgggtccag ccaagcattt gctagtgtgg aagaagcatt gcatgcattt
     1321 attcagccag agattctgga tggcccaaat cagtattttt gtgaacgttg taagaagaag
     1381 tgtgatgcac ggaagggcct tcggtttttg cattttcctt atctgctgac cttacagctg
     1441 aaaagattcg attttgatta tacaaccatg cataggatta aactgaatga tcgaatgaca
     1501 tttcccgagg aactagatat gagtactttt attgatgttg aagatgagaa atctcctcag
     1561 actgaaagtt gcactgacag tggagcagaa aatgaaggta gttgtcacag tgatcagatg
     1621 agcaacgatt tctccaatga tgatggtgtt gatgaaggaa tctgtcttga aaccaatagt
     1681 ggaactgaaa agatctcaaa atctggactt gaaaagaatt ccttgatcta tgaacttttc
     1741 tctgttatgg ttcattctgg gagcgctgct ggtggtcatt attatgcatg tataaagtca
     1801 ttcagtgatg agcagtggta cagcttcaat gatcaacatg tcagcaggat aacacaagag
     1861 gacattaaga aaacacatgg tggatcttca ggaagcagag gatattattc tagtgctttc
     1921 gcaagttcca caaatgcata tatgctgatc tatagactga aggatccagc cagaaatgca
     1981 aaatttctag aagtggatga atacccagaa catattaaaa acttggtgca gaaagagaga
     2041 gagttggaag aacaagaaaa gagacaacga gaaattgagc gcaatacatg caagataaaa
     2101 ttattctgtt tgcatcctac aaaacaagta atgatggaaa ataaattgga ggttcataag
     2161 gataagacat taaaggaagc agtagaaatg gcttataaga tgatggattt agaagaggta
     2221 atacccctgg attgctgtcg ccttgttaaa tatgatgagt ttcatgatta tctagaacgg
     2281 tcatatgaag gagaagaaga tacaccaatg gggcttctac taggtggcgt caagtcaaca
     2341 tatatgtttg atctgctgtt ggagacgaga aagcctgatc aggttttcca atcttataaa
     2401 cctggagaag tgatggtgaa agttcatgtt gttgatctaa aggcagaatc tgtagctgct
     2461 cctataactg ttcgtgctta cttaaatcag acagttacag aattcaaaca actgatttca
     2521 aaggccatcc atttacctgc tgaaacaatg agaatagtgc tggaacgctg ctacaatgat
     2581 ttgcgtcttc tcagtgtctc cagtaaaacc ctgaaagctg aaggattttt tagaagtaac
     2641 aaggtgtttg ttgaaagctc cgagactttg gattaccaga tggcctttgc agactctcat
     2701 ttatggaaac tcctggatcg gcatgcaaat acaatcagat tatttgtttt gctacctgaa
     2761 caatccccag tatcttattc caaaaggaca gcataccaga aagctggagg cgattctggt
     2821 aatgtggatg atgactgtga aagagtcaaa ggacctgtag gaagcctaaa gtctgtggaa
     2881 gctattctag aagaaagcac tgaaaaactc aaaagcttgt cactgcagca acagcaggat
     2941 ggagataatg gggacagcag caaaagtact gagacaagtg actttgaaaa catcgaatca
     3001 cctctcaatg agagggactc ttcagcatca gtggataata gagaacttga acagcatatt
     3061 cagacttctg atccagaaaa ttttcagtct gaagaacgat cagactcaga tgtgaataat
     3121 gacaggagta caagttcagt ggacagtgat attcttagct ccagtcatag cagtgatact
     3181 ttgtgcaatg cagacaatgc tcagatccct ttggctaatg gacttgactc tcacagtatc
     3241 acaagtagta gaagaacgaa agcaaatgaa gggaaaaaag aaacatggga tacagcagaa
     3301 gaagactctg gaactgatag tgaatatgat gagagtggca agagtagggg agaaatgcag
     3361 tacatgtatt tcaaagctga accttatgct gcagatgaag gttctgggga aggacataaa
     3421 tggttgatgg tgcatgttga taaaagaatt actctggcag ctttcaaaca acatttagag
     3481 ccctttgttg gagttttgtc ctctcacttc aaggtctttc gagtgtatgc cagcaatcaa
     3541 gagtttgaga gcgtccggct gaatgagaca ctttcatcat tttctgatga caataagatt
     3601 acaattagac tggggagagc acttaaaaaa ggagaataca gagttaaagt ataccagctt
     3661 ttggtcaatg aacaagagcc atgcaagttt ctgctagatg ctgtgtttgc taaaggaatg
     3721 actgtacggc aatcaaaaga ggaattaatt cctcagctca gggagcaatg tggtttagag
     3781 ctcagtattg acaggtttcg tctaaggaaa aaaacatgga agaatcctgg cactgtcttt
     3841 ttggattatc atatttatga agaagatatt aatatttcca gcaactggga ggttttcctt
     3901 gaagttcttg atggggtaga gaagatgaag tccatgtcac agcttgcagt tttgtcaaga
     3961 cggtggaagc cttcagagat gaagttggat cccttccagg aggttgtatt ggaaagcagt
     4021 agtgtggacg aattgcgaga gaagggtaga ggaacatttc cctgtgatat ttctgtcctt
     4081 gatattcatc aggatttaga ctggaatcct aaagtttcta ccctgaatgt ctggcctctt
     4141 tatatctgtg atgatggtgc ggtcatattt tatagggata aaacagaaga attaatggaa
     4201 ttgacagatg agcaaagaaa tgaactgatg aaaaaagaaa gcagtcgact ccagaagact
     4261 ggacatcgtg taacatactc acctcgtaaa gagaaagcac taaaaatata tctggatgga
     4321 gcaccaaata aagatctgac tcaagactga ctctgatagt gtagcatttt ccctggggga
     4381 gttttggttt taattagatg gttcactacc actgggtagt gccattttgg ccggacatgg
     4441 ttggggtaac ccagtgacac cagcactgat tggactgccc tacaccaatc agaagctcag
     4501 tgcccaatgg gccactgttt tgactcggaa tcatgttgtg cactatagtc aaatgtactg
     4561 taaagtgaaa agggatgtgc aaaaaaataa aaaaaaacaa caaaaaaagc taaccttcta
     4621 ttagaaaagg ggacagggga atgagtaaac ttcttttatt gcggacaaat gtgcacatag
     4681 ccgctagtaa aactagcctc aaacaggatg ctcatagctt aataataaaa gctgtgcaaa
     4741 ggccatgaat gaatgaattt tctgtttatt tcactgatgc acacattacc tcattgacaa
     4801 ttcagaagta aatccaacgt gtgttgactc ttggaaagca gcaaaaacag gagctgaaga
     4861 aaagaaattc ttggaaccag ccgtaaccca gtaaggaatt gtgaagttgt gtttttattt
     4921 tgtttcattt tttgcagagt attaagaaca ttattctgga acatcagaac gtttccctta
     4981 gaccgatccc agcaggtggc agctcagatt gctgcagtgt tgtaattata actgattgta
     5041 cttaagttat ggatgtagag aatatgtttc attcatttat tcagcatgta aataaaattg
     5101 atcctgttga gttatcataa ttgcagttca actatctgcc atgattattc ttttcacgta
     5161 tcattcattc tgtacatttg tgtacattga gaagtatagc aatctatgta aatgtaatcc
     5221 tcagtgaggt tcctcagtgc taggtcccat aggattgtcg ttgcccttgt taatgaggtt
     5281 tctctgttca gcggcttcaa tttttttctc tttgtacatc tagttttgaa gatttacttc
     5341 aagtttgaat cttctagaat gcttgtaagt ccagttttaa tttttagagt caatttgtag
     5401 ttacatgtag tttaactttt gggaaacgtc ttaacattgt tctgaataaa cttgctaatg
     5461 aggtcaggtc atggtacaga ctgatgcagt caacatgatt tcattgcaga gtttattagt
     5521 atcagcaagt ttttgctttg ctaaataaaa gtactcaatg aacacaattc tacataaatt
     5581 ttgacatacc atctaattta taaaaatcaa taaaaaaggt tttggtaaaa ctttttcatg
     5641 ccagatgctg tttacaacaa tgaacatgcc aataaaacat ttgttcattc tgttgtgtta
     5701 ttttagtcat taaacttctg tggatgaaga atctgggtta agaatagatt tgtcatcttt
     5761 aaatatgaca ttttgtaatg tgtattggat atctcatttc tatgataaag gtatatttac
     5821 agtaaagttc tcataagaga aatgaaaagc tgtgttaata tctaactttg gggaaccctg
     5881 tcagtatttc agatccgatt tttacccttt ttttcttata agaaagataa aattagaaaa
     5941 tactgttagc aaatgtggct ctgccatttg aatataatca ccgagaattc catgtcttaa
     6001 aagtctcctg gaatccacaa tgaaaaaaaa aatcttttct aaggtatttt tctggctaat
     6061 ttttatttga agaaagctat agcatttagc gaaatttgac tgaagtaatg ttctgagttt
     6121 gcattagtgg gattggtgat gttctcagaa gaaaattgga aacacttgtg atgaattgtc
     6181 tttcagatca cttagatttt ctgatgtaag aggacagctg tttggttctg atacaggcct
     6241 gcttacttgg gatgtagggt tagtaaatgg ggtttctgct ttaaaggact gacttgctat
     6301 cacacaaaag aggcagactt gtaaacacaa tgggctttgg agtttggtct gattgggttt
     6361 ggtttagtat tcctatgagc gtaaatggta aaattcttct gatacccact ctttagactg
     6421 tgccttctgc tctgttcttt gttttatgtt taactgctgt ttctaattgc aggtgtatta
     6481 cagatacaaa taagagtaaa gaaaatatat ttcattatag aaaagaaaaa attaaaagct
     6541 tcttgctttt cagtgcctga tagagtgaaa acacaaagtt gcactttaat aatttcaata
     6601 aaagctaatc tgtgtcagcc tccctctgct tcagagagtc aggtgagcat ccataaccta
     6661 acaggcagag ccctagcgat gtggatcaag tttcctgagc ccgggggcgg tggagcctca
     6721 tgatctctta tcttttgagg ctgaggcagg tcacatgcaa caaattgtga ccctgctccc
     6781 cacaagtcat gcaaaggttt tgaagagctt ttaccgtggg gcagatgaac ttgtgtcaac
     6841 catgcacacc ctgtgagaac caagtacctg tgtttctaag gcgggcactc aaggtgaggg
     6901 gtgcattctg gccaaagaaa caaaagctgt ggtttcagga ccatgccgtg tgtagctgat
     6961 ctgtacggga cgtgtatgta aggaagagca atcatgatag ataagaacag tgtgtgaagc
     7021 agccttcaca ctagagtgtt tggtcatctc ttataatgta agggaaggta ctttaaaatt
     7081 ctgggaagat gcgatgaact catgtcccag tcagaaaata atccaatgaa ataagcattg
     7141 gttgccaggc cacagttagg aattgtattg tgatacatct agaggccaag agagcaggag
     7201 agagctacca acttacactg tggtttaagc taaatgaccg cacagcatca tagcattgca
     7261 gtgttgttac taaatctgga agtgacctgt gaatgtatgg aatacaataa agtcttttat
     7321 tctggttcat ttgctagtac ttcctttttg attggatact gtagttcttc ctctggattt
     7381 tattttgttc agcgtcaagg ccctaatttt gcaaatgtag tctaaaccac attacgtgga
     7441 ctagaggata ctctgaatta gcaagttttt tgtttgctga ataaaactat tccatcttaa
     7501 caattctgtg taatttttga aaaacatcaa cattttggtc actagtagtc aaaatcttat
     7561 aaggccatat gtcctgaaag gcaaaactct gtgtatgtgc gatttaccag ggagatagta
     7621 ggacagtttt tatgagggtt tcaaaggagt tcatggccca aatgaagctt gtggccacct
     7681 aggtttagtg tacatgaaat tggaagatgc ttcttgattg tagttcccat ggggaagagg
     7741 gaggctgtga tcatttggtt agatacagca ttaattgtca caacttgact ttcagaaaca
     7801 agaatactgc acaaactcaa gcatgcattg gagcatgtgt tactatttag aaaagagtgc
     7861 agccatcagt aggtcaagct aggagggcaa aagagagttg agaggaatgc tctgcccctt
     7921 ccccatcaca gcactgcccc tttccacctc ctcaccagct cacctgtaca agagaattga
     7981 tctcaactga gtgtcagctc accaggtcag aaattgttat tggaccctaa aaccttgcct
     8041 cacaggtggg caccaagctc cccttccctc tgctttccat gtttcccacc tgccctctcc
     8101 ccacctgttt tcagcctctt ttataatgct taagtaacct gcttgaagag tataatttat
     8161 ggagataaaa atactcaatg cttacatttt tttcataact gtgccaattg ttttgtcaaa
     8221 tgcagttacc cactgggcag tgggcttatc aagtgctcag tgcaatcctg tgacttttaa
     8281 gtcattttgc attattaaga caatcttatc ttaaagttca gtggtttcat tcaaagctcc
     8341 cctgaacctc catagtgcct ccaagatgtg ctgtccctgc caactcctgc accagcttga
     8401 ctggtggtgg aagaggccag gaagagcggg gggaagacat gtgctaacca cttcttagca
     8461 atgaggctgg taaggttact gtccccttgt gcctggtcac tagtaacttt tttgtagaca
     8521 tgaaggtaga tgccctgcag gtcctatcag caaaggaccc aactcctaac agcattggtg
     8581 ctccctcatg aaatttgaca gtgtcttgcc agcctcctgc tggcagacac ttctctgcag
     8641 tgaataccac tatcccatgc tgcactagtc cctaccaagt cttcaaccct caatttgatc
     8701 ttccatgagt gtctcaaaaa gttcccctca gaagtttcag ccaagggaat aaaatctaac
     8761 ctctcctccc tcaacggagt gtcagggagg ggaagaatct gttttccaaa caccacaatc
     8821 tcccaaaagg ggatttcacc ctcccttggt catctttata cagggcaatt gtgctgctgc
     8881 tgctgaggtg gccactttca gcaagccctg tgtgcagggg cctagctgca tttagaaacc
     8941 aagcatagct atcaaaaagt aatctccaaa tagttgaatt gcatttcttg agtatctgga
     9001 gaggatgtgc agaccacagg aatacctaat gccttttttc tcttcctgtc tttgtccctc
     9061 acactacagc aggcccctcc cttccctctt caacctcatc ctccctcccc acaggcccag
     9121 agaaccagtt gggctttgtt ctcctgcagg ctatggttca tcatgcaaat agctcctgtg
     9181 tcagaaatgc tttttggctt caaataacag aaaagctaac accagcttta tcaataataa
     9241 tatcggtggt ttacttaagg tgtccagaga tggtggagaa caggattggt ttcctcctca
     9301 atgtcaagga ctcaaagact ctttctgtgg tagggccaca tcctaaaccc tgtatcctgt
     9361 gattatttac ctgacagggc aaaagagatt ttgcagatgc aattaaggtt aaggaccttg
     9421 acgtgggaag attgtgatta tttacctgac agggcaaaag agattttgca gatgcaatta
     9481 aggttaagga ccttgacgtg ggaagattat tctggattat ctaggtgggc gcaatttgat
     9541 cacatgggtc cccagaagtg gagaaccttt cccacctgta gaaagccaga gagctggcac
     9601 ctgagaagga cagaactgtc attgcaggat ttgaagatga aggggcccat gagccaagga
     9661 atgccagtga cctatagagg ctaaaaaaca gcaaggaaat ggactctccc cagagcctcc
     9721 agaggaatgc agccctgttg atcacatgat caccagatgg ctgccccaga gccaaatgtc
     9781 gcttcctgag caccatactc aaaggcaggg gaagtggatg gagggcagga gctccattct
     9841 tgtttgccac tctccttttg tcaattggga aaaaattcca gaaactctgg gagccctccc
     9901 cttacatttc ctgggtcatg gggccagccc tagctgctgg agggactgag aacagctgtt
     9961 gagcagttta cctgacggca tctgccatgg cttggcagga actctggctt tgggagagag
    10021 cagcagcaag gtattcaagc accacctcca cccagcccct cc
//
