LOCUS       NM_022832               7932 bp    mRNA    linear   PRI 12-DEC-2024
DEFINITION  Homo sapiens ubiquitin specific peptidase 46 (USP46), transcript
            variant 1, mRNA.
ACCESSION   NM_022832
VERSION     NM_022832.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 7932)
  AUTHORS   Jiang,L., Qi,X., Lai,M., Zhou,J., Yuan,M., You,J., Liu,Q., Pan,J.,
            Zhao,L., Ying,M., Ji,J., Li,K., Zhang,Y., Pan,W., He,Q., Yang,B.
            and Cao,J.
  TITLE     WDR20 prevents hepatocellular carcinoma senescence by orchestrating
            the simultaneous USP12/46-mediated deubiquitination of c-Myc
  JOURNAL   Proc Natl Acad Sci U S A 121 (44), e2407904121 (2024)
   PUBMED   39432777
  REMARK    GeneRIF: WDR20 prevents hepatocellular carcinoma senescence by
            orchestrating the simultaneous USP12/46-mediated deubiquitination
            of c-Myc.
REFERENCE   2  (bases 1 to 7932)
  AUTHORS   Ng,V.H., Spencer,Z., Neitzel,L.R., Nayak,A., Loberg,M.A., Shen,C.,
            Kassel,S.N., Kroh,H.K., An,Z., Anthony,C.C., Bryant,J.M.,
            Lawson,A., Goldsmith,L., Benchabane,H., Hansen,A.G., Li,J.,
            D'Souza,S., Lebensohn,A.M., Rohatgi,R., Weiss,W.A., Weiss,V.L.,
            Williams,C., Hong,C.C., Robbins,D.J., Ahmed,Y. and Lee,E.
  TITLE     The USP46 complex deubiquitylates LRP6 to promote Wnt/beta-catenin
            signaling
  JOURNAL   Nat Commun 14 (1), 6173 (2023)
   PUBMED   37798301
  REMARK    GeneRIF: The USP46 complex deubiquitylates LRP6 to promote
            Wnt/beta-catenin signaling.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 7932)
  AUTHORS   Ke,L., Jia,Z., Gao,W. and Luo,L.
  TITLE     Ubiquitin specific protease 46 potentiates triple negative breast
            cancer development by stabilizing PGAM1-mediated glycolysis
  JOURNAL   Cell Biol Int 47 (1), 41-51 (2023)
   PUBMED   36335636
  REMARK    GeneRIF: Ubiquitin specific protease 46 potentiates triple negative
            breast cancer development by stabilizing PGAM1-mediated glycolysis.
REFERENCE   4  (bases 1 to 7932)
  AUTHORS   Wen,M., Xu,H., Peng,H., Sheng,Y., Yang,W. and Yan,J.
  TITLE     MiR-27a-3p targets USP46 to inhibit the cell proliferation of
            hepatocellular carcinoma
  JOURNAL   Chem Biol Drug Des 100 (2), 280-289 (2022)
   PUBMED   35637630
  REMARK    GeneRIF: MiR-27a-3p targets USP46 to inhibit the cell proliferation
            of hepatocellular carcinoma.
REFERENCE   5  (bases 1 to 7932)
  AUTHORS   Qiu,Y., Huang,D., Sheng,Y., Huang,J., Li,N., Zhang,S., Hong,Z.,
            Yin,X. and Yan,J.
  TITLE     Deubiquitinating enzyme USP46 suppresses the progression of
            hepatocellular carcinoma by stabilizing MST1
  JOURNAL   Exp Cell Res 405 (1), 112646 (2021)
   PUBMED   34029571
  REMARK    GeneRIF: Deubiquitinating enzyme USP46 suppresses the progression
            of hepatocellular carcinoma by stabilizing MST1.
REFERENCE   6  (bases 1 to 7932)
  AUTHORS   Sowa,M.E., Bennett,E.J., Gygi,S.P. and Harper,J.W.
  TITLE     Defining the human deubiquitinating enzyme interaction landscape
  JOURNAL   Cell 138 (2), 389-403 (2009)
   PUBMED   19615732
REFERENCE   7  (bases 1 to 7932)
  AUTHORS   Cohn,M.A., Kee,Y., Haas,W., Gygi,S.P. and D'Andrea,A.D.
  TITLE     UAF1 is a subunit of multiple deubiquitinating enzyme complexes
  JOURNAL   J Biol Chem 284 (8), 5343-5351 (2009)
   PUBMED   19075014
  REMARK    GeneRIF: two novel multisubunit deubiquitinating enzyme complexes
            containing USP12 and USP46, respectively. Both complexes contain
            the UAF1 protein as a bona fide subunit. Interestingly, UAF1
REFERENCE   8  (bases 1 to 7932)
  AUTHORS   Zemunik,T., Boban,M., Lauc,G., Jankovic,S., Rotim,K., Vatavuk,Z.,
            Bencic,G., Dogas,Z., Boraska,V., Torlak,V., Susac,J., Zobic,I.,
            Rudan,D., Pulanic,D., Modun,D., Mudnic,I., Gunjaca,G., Budimir,D.,
            Hayward,C., Vitart,V., Wright,A.F., Campbell,H. and Rudan,I.
  TITLE     Genome-wide association study of biochemical traits in Korcula
            Island, Croatia
  JOURNAL   Croat Med J 50 (1), 23-33 (2009)
   PUBMED   19260141
  REMARK    GeneRIF: Observational study and genome-wide association study of
            gene-disease association. (HuGE Navigator)
REFERENCE   9  (bases 1 to 7932)
  AUTHORS   Quesada,V., Diaz-Perales,A., Gutierrez-Fernandez,A., Garabaya,C.,
            Cal,S. and Lopez-Otin,C.
  TITLE     Cloning and enzymatic analysis of 22 novel human ubiquitin-specific
            proteases
  JOURNAL   Biochem Biophys Res Commun 314 (1), 54-62 (2004)
   PUBMED   14715245
REFERENCE   10 (bases 1 to 7932)
  AUTHORS   Puente,X.S., Sanchez,L.M., Overall,C.M. and Lopez-Otin,C.
  TITLE     Human and mouse proteases: a comparative genomic approach
  JOURNAL   Nat Rev Genet 4 (7), 544-558 (2003)
   PUBMED   12838346
  REMARK    Review article
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CN483539.1, BC037574.1, AC026448.5 and BU620990.1.
            
            On Nov 23, 2018 this sequence version replaced NM_022832.3.
            
            Summary: Modification of cellular proteins by ubiquitin is an
            essential regulatory mechanism controlled by the coordinated action
            of multiple ubiquitin-conjugating and deubiquitinating enzymes.
            USP46 belongs to a large family of cysteine proteases that function
            as deubiquitinating enzymes (Quesada et al., 2004 [PubMed
            14715245]).[supplied by OMIM, Jun 2009].
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803612.45934.1,
                                           SRR1660803.141938.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000441222.8/ ENSP00000407818.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-28                CN483539.1         35-62
            29-3858             BC037574.1         12-3841
            3859-7638           AC026448.5         31700-35479         c
            7639-7932           BU620990.1         16-309              c
FEATURES             Location/Qualifiers
     source          1..7932
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4q12"
     gene            1..7932
                     /gene="USP46"
                     /note="ubiquitin specific peptidase 46"
                     /db_xref="GeneID:64854"
                     /db_xref="HGNC:HGNC:20075"
                     /db_xref="MIM:612849"
     exon            1..187
                     /gene="USP46"
                     /inference="alignment:Splign:2.1.0"
     CDS             152..1252
                     /gene="USP46"
                     /EC_number="3.4.19.12"
                     /note="isoform 1 is encoded by transcript variant 1;
                     ubiquitin carboxyl-terminal hydrolase 46; ubiquitin
                     thioesterase 46; deubiquitinating enzyme 46;
                     ubiquitin-specific-processing protease 46; ubiquitin
                     thiolesterase 46"
                     /codon_start=1
                     /product="ubiquitin carboxyl-terminal hydrolase 46 isoform
                     1"
                     /protein_id="NP_073743.2"
                     /db_xref="CCDS:CCDS47053.1"
                     /db_xref="GeneID:64854"
                     /db_xref="HGNC:HGNC:20075"
                     /db_xref="MIM:612849"
                     /translation="MTVRNIASICNMGTNASALEKDIGPEQFPINEHYFGLVNFGNTC
                     YCNSVLQALYFCRPFRENVLAYKAQQKKKENLLTCLADLFHSIATQKKKVGVIPPKKF
                     ISRLRKENDLFDNYMQQDAHEFLNYLLNTIADILQEEKKQEKQNGKLKNGNMNEPAEN
                     NKPELTWVHEIFQGTLTNETRCLNCETVSSKDEDFLDLSVDVEQNTSITHCLRDFSNT
                     ETLCSEQKYYCETCCSKQEAQKRMRVKKLPMILALHLKRFKYMEQLHRYTKLSYRVVF
                     PLELRLFNTSSDAVNLDRMYDLVAVVVHCGSGPNRGHYITIVKSHGFWLLFDDDIVEK
                     IDAQAIEEFYGLTSDISKNSESGYILFYQSRE"
     exon            188..268
                     /gene="USP46"
                     /inference="alignment:Splign:2.1.0"
     exon            269..482
                     /gene="USP46"
                     /inference="alignment:Splign:2.1.0"
     exon            483..712
                     /gene="USP46"
                     /inference="alignment:Splign:2.1.0"
     exon            713..789
                     /gene="USP46"
                     /inference="alignment:Splign:2.1.0"
     exon            790..873
                     /gene="USP46"
                     /inference="alignment:Splign:2.1.0"
     exon            874..1071
                     /gene="USP46"
                     /inference="alignment:Splign:2.1.0"
     exon            1072..1150
                     /gene="USP46"
                     /inference="alignment:Splign:2.1.0"
     exon            1151..7932
                     /gene="USP46"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3180..3185
                     /regulatory_class="polyA_signal_sequence"
                     /gene="USP46"
                     /note="hexamer: ATTAAA"
     polyA_site      3202
                     /gene="USP46"
                     /note="major polyA site"
     polyA_site      4695
                     /gene="USP46"
     regulatory      4706..4711
                     /regulatory_class="polyA_signal_sequence"
                     /gene="USP46"
                     /note="hexamer: AATAAA"
     polyA_site      4718
                     /gene="USP46"
                     /note="major polyA site"
     regulatory      4734..4739
                     /regulatory_class="polyA_signal_sequence"
                     /gene="USP46"
                     /note="hexamer: ATTATA"
     polyA_site      4755
                     /gene="USP46"
     regulatory      7901..7906
                     /regulatory_class="polyA_signal_sequence"
                     /gene="USP46"
                     /note="hexamer: AATAAA"
     polyA_site      7932
                     /gene="USP46"
ORIGIN      
        1 ctcctcccgg cctccctctc ccagccaaac tgaaagccgg accccaggcc gccgcgctgc
       61 cgcccggcct ccccgccagc gcgccaccat gggcagtccc ggtttcccct tgtaaagatg
      121 gcggtgaggg atcgctgcaa cctttagact aatgactgtc cgaaacatcg cctccatctg
      181 taatatgggc accaatgcct ctgctctgga aaaagacatt ggtccagagc agtttccaat
      241 caatgaacac tatttcggat tggtcaattt tggaaacaca tgctactgta actccgtgct
      301 tcaggcattg tacttctgcc gtccattccg ggagaatgtg ttggcataca aggcccagca
      361 aaagaagaag gaaaacttgc tgacgtgcct ggcggacctt ttccacagca ttgccacaca
      421 gaagaagaag gttggcgtca tcccaccaaa gaagttcatt tcaaggctga gaaaagagaa
      481 tgatctcttt gataactaca tgcagcagga tgctcatgaa tttttaaatt atttgctaaa
      541 cactattgcg gacatccttc aggaggagaa gaaacaggaa aaacaaaatg gaaaattaaa
      601 aaatggcaac atgaacgaac ctgcggaaaa taataaacca gaactcacct gggtccatga
      661 gatttttcag ggaacgctta ccaatgaaac tcgatgcttg aactgtgaaa ctgttagtag
      721 caaagatgaa gattttcttg acctttctgt tgatgtggag cagaatacat ccattaccca
      781 ctgtctaaga gacttcagca acacagaaac actgtgtagt gaacaaaaat attattgtga
      841 aacatgctgc agcaaacaag aagcccagaa aaggatgagg gtaaaaaagc tgcccatgat
      901 cttggccctg cacctaaagc ggttcaagta catggagcag ctgcacagat acaccaagct
      961 gtcttaccgt gtggtcttcc ctctggaact ccggctcttc aacacctcca gtgatgcagt
     1021 gaacctggac cgcatgtatg acttggttgc ggtggtcgtt cactgtggca gtggtcctaa
     1081 tcgtgggcat tatatcacta ttgtgaaaag tcacggcttc tggcttttgt ttgatgatga
     1141 cattgtagag aaaatagatg ctcaagctat tgaagaattc tatggcctga cgtcagatat
     1201 atcaaaaaat tcagaatctg gatatatttt attctatcag tcaagagagt aactgaaaga
     1261 cctgcgggac tgattcacgt ggggagaatg ttcacagcac tgtcacccgg cttctccgca
     1321 ggctttcctc ttccccagtg gcccactaat ggtatcactc cgagtctcaa tggtctggct
     1381 gtgttagact ctctcctttt gtgtttttac atgcagcact actcttggtt ttatttcagt
     1441 ctgacataga gttaactgca atcagattgt agtctgattt atatgaataa cggttgctaa
     1501 ttttaggact gggtgaaagc tatgccattc attatgtctg gctgtattag aatgacattt
     1561 cctatgaatg tctacggtct gttttaggtg tttgctaaac ttctatggct tccagggtct
     1621 tcttacaatg cattccttta acttgtccct ggaagcattg ctacccattt tcagcttctc
     1681 tgcctctctt ctgatacaag gacagaagaa ttgggtagat attcaccttt taggggtgca
     1741 agtatagctt taagtttgtg caagtgaaaa tgttgaaaag tgagtaacct cgatattaaa
     1801 atcatccttg acatgaaaca gggtgaagag aagctgtccg tggcggctgg tgttggctgg
     1861 cattggcact gggctgtgct gacctagcca ttacaattcc aggggctaag aaggctcagg
     1921 gcagacaaag tcaagaggag gaagtttttg tggacaatga aaagttattt tcgtaccttt
     1981 ctaccaaaac caagtttcag gaaaataact ctatgttgtt tattttcagt gacacttatg
     2041 taaggccctg tgagttgtat ttatcctgta tccggcactg ctaagctttt caaggtatct
     2101 ttccaatcct gctgatgtgg cagtcaatgg ctgcagggct ggcaaacctc cccttagcca
     2161 gtcagcacgg cattgttcct tatcaggaat aacaaaggta ctacatcttt ccagccatca
     2221 gcacgttgta caacttaact ttttaacata gtccgtctgt ttactgaggc actggcgagt
     2281 cccagggctg atacagaacc ttccctagag ggaataccag agttagctgg gtatagaggt
     2341 ggctcaaagg aagtgtccgt gggcaggggg aggaatgaac aaaatggcgc tgtttctttg
     2401 gctcagactc ctagaatgct tgacaagaca gaattttttt ggaagaacct catctcacta
     2461 tagttacttt tttcactttt gttatatatg tatttattag agcatttgaa tattggtacc
     2521 tttaaaaggg tcatttggtg ttttgctgtt gagctggttt ttgagtcata gatcttggct
     2581 tcctttagaa gccacttaac ttccatacac tataataaac tgtgaacata tttttgttac
     2641 ctaatgcatc cactgatgaa catgcaaact ttgggcataa tgtgaactaa aattgaaatg
     2701 gaaaatgtta gtggccattt tgcaacaatg aagaggatag cactttatct agatgaaaac
     2761 tggatttctt atctttgaaa tatcttgaac tgtttattgc tcagaactta agtaagcatg
     2821 ccaacatttc gtttgtttat gcttgaagtg aaatgtttta cttttcactg gagaagacaa
     2881 aacagggtga tcttcatgtt attgttttat acaagtgatg gaaatgtacc ttgccttgtt
     2941 tagaggcaat ttcacattta taaatatttt tttttcctcc atgaaactta cgcagtaatc
     3001 actacctgga aggtgagttt tgatctcttt ttaaggagag gcactttcca actgaaggtg
     3061 attgatgtag ggaaatgttt gtactatata gaatccatat atttgactgc aagttacaaa
     3121 gttttaagaa catgatggtt ggtctctaat atatttggaa ctgattcata agaaaagtta
     3181 ttaaaattat ctttgaaaca cctcttgaag ctaatttatt agaaaaaata tttcagttgg
     3241 aaggctgtag aagtaatgtt taaatgctaa gtcataagtt caggatattt cttttctatt
     3301 tggttgtgca aaatgttttt cccagttatt taatcgaagt aattcctttt aatagaaaga
     3361 gtcagttaaa attcagcatt catggataga tttttggaac gaaaaagggt aagtataaga
     3421 aaatattgca aacacattaa aacagttgta tggtgcagga aaagaagatt ggaaaaagac
     3481 caaaacacac ttctccagca acactccatc agctttttaa aatttagagc tatctgctaa
     3541 ttttttccct cttccttctc aataaatgaa acaaacactg ggcagctgca ggtttctccc
     3601 aatcatgtct ctttatgtaa agacagtaac atgcaaacac ttttagttta catccctcat
     3661 tcacagtgta aagcaggaaa tggtgtggga gatgtgagac cattctgagg tcagcgatag
     3721 cccaaaggct ctgcagtatt ccctccaatg gccaaggatt ccgtgtgtca tctgcaggag
     3781 tgagtaggcc tgctgtattt cttgtaactg ctgggtgtta caaaataagt tacaatgttt
     3841 tacactttaa aaaaaaaaca gaaggaacat ttgctttatt ggttacttac tagtttagcc
     3901 tctaggttat ggcacagcat gctaaaaaat catgtgttta aaagtaaatg ttggtaaaat
     3961 gctggcatct ggtcctattg tgttgatgca ttttcacttc tgtggtcata ggaaatggac
     4021 tggtctaaag agagtgaggc acaacacaag cagggcatta gtttgaatag gaagtcaatc
     4081 atatttggtt ttatggcctg gtgtattttg ggtttaagat aaaataggga aaaatgtcag
     4141 aaatgatccc tatgcattta ttttcatgga tacccttaat ttcatgggca tgcctaataa
     4201 tgatctatgt tctaactgga gcttagggct tattttagat attggagtgt agctttatta
     4261 cagatggatt ttatctttca acattgcatt ttgatcaact ttgtatattc acgtgtatta
     4321 aaatattgtg cactaaatgt tttgcccttg tttgctatta tatggtcaag gcatttatca
     4381 gcactattgt aatgaactca tgtaagtggc atgggtcagg gaaaattatt tcctactttt
     4441 ctgcctaatt aaatttctgt tttccagtat tacattaatt tatttttggc ttccatttct
     4501 gtataaccaa aatagttact gtatttgtgt ggcattccta ttattttgtt gctaaaaata
     4561 ttgtagtttt tatttaaaat aatctgtacc ttaatttttt aaaatgtaac caattcaagc
     4621 actttaagca ataatgtcaa tcttgtgaaa ttttaatcag tttaacaccc tgcctctaaa
     4681 attgtttgca aaaaataaat aaatgaataa aatgggaatt ctctttctag agaattatat
     4741 ccgggtaatg ctacacacat ggacttaaaa tcctttttat aaagtgtgag tcagtggcag
     4801 gtcttatgtc caagtaatta ttacaaacaa ttttgaagca gtggaaatgt acagaacatt
     4861 ctgatcatta taatatataa aggcagtatt actctcaagg ttgataaaaa tcaatgttct
     4921 ggagataact catcactttt tttgagtgaa aaagatcaac agaatttaat tcaggaaatg
     4981 gtatctggag aatagcaaat tgagaatatc agtgaaaaga atttagggat agttaactag
     5041 gcatcacagt gaatttattt ttggggactt tgcatataaa atccttttaa ccagttatga
     5101 aatgaaagat ccattcccca aataagaagg cagcttccag tatctggttt ctaggaagga
     5161 gtaggactgt gattggtccc tggtgccctg acttctgggc ctgtttctga gccatggggg
     5221 accccccagc ttcagaaata ctcacgtggg ttcacaccac tccctgcccc agaaggaggg
     5281 caggcacagg tccatgccat gtggcctcag tgaagcctac agtaactatg ggtagggctg
     5341 cttttccctg tcaatcaccc agggcacctg tgggtggaca gaagattgtc atcggaatac
     5401 atgcttgggc ccaattatgg gaataaaacc tcatagacca agagcaggga atgtgccagt
     5461 aagtgttgag tctcccagct gctgtccatc ttctcggggc agtgcagttg aacctgactg
     5521 agctggaaca gagactgttg ggaaggtcac ttctgtctgc cacgaaggcc aaaggcagag
     5581 aagaccttct tgggactgtg tttttctttc ctaggcctca ctttgtcctg ggatttatag
     5641 gacaggcctg tcactaccaa ggtgacacaa attctagaga atgtattttc ccatttcttc
     5701 aaatttcctt tcctctcttt ttattgatac ttaaaatacc tttactaaaa aaatgaagcc
     5761 ttccatttcc attcccttat atttacatga agataaaaat acttactaag tcgttgtatt
     5821 tgtccattct ggcagtgcta taaagacata cctgagcgtg ggtcatttct gaagaaaaga
     5881 ggtttaattg gctcatggtt ttatgggctg tacaggcttc tgttctgggg gaggcctcag
     5941 gaaacttaca atcagcagaa ggcaaaggga aagcaagccc atcttacatg gcaggagcaa
     6001 gaggaagaga gcaaaggggg aggggttaca cacttttctt tccttttttt tttttaagat
     6061 ggagtctcac tgtcacccag gctggagtgc agtgatgaga tctcagctca ctgcaacctc
     6121 tgcctcccga gttcaagcga ttcttctgcc tcagcctccc aagtagctgg gactacaggc
     6181 atgtgccact atacccgggt aatttttgta ttttcagtag atacaaagtt ttctcatatt
     6241 ggccaagctg gtctggaact cctgacttca ggtgcctcag cctcccaaag tgctgggatt
     6301 acaggcaaga gccaccttgc tcggctgggg ttacacactt ttaaacaacc agatctcgtg
     6361 agaactcagt catgaggcag tactaggggg atggtgctta accacctatg atgcaatcac
     6421 ctcccaccag gccccacctc caacactggg gattacaatt caacatggga tttgggtgga
     6481 gacacagagc caaaccgtat cagtcatttt tcttttactg aaggaaaatt ttggttgtgg
     6541 ggttagtact aaagatagcc catgtagact ttttctgaag ataccccaag tggagagatt
     6601 tttaattagg catttatttg gcacctattg cattctaggc attgtgatag gagctggggg
     6661 ataaaaaggt gacacagatt gggtccctct tatggactcg ttttttgtct cagaagacaa
     6721 gtctgggtga gaaagaaatt taaaatttaa gttgtggaaa taacacgtgt gggggaaact
     6781 ccttgcaatt cagcacagtt tggtattcag ccccagcctc aacatgcaga tggcactgtt
     6841 ggatgaagcc acaccatctt ttttcctggg agccccacac tcttcccagc ctgccttcta
     6901 gctcagggac aacacatttt gaaaaacaaa gtataaatcg attatgttgc aacaatgaac
     6961 ttcacgtttt gcctcttctc atgttaaaag agccagtatc atgaaagcct caacagtgag
     7021 ctttatgaat caaatatctg ttatttctaa acaatctgtt tacattatga ccaaataatt
     7081 agagcctatc tagacttacc aaaataagat agggcataag cgatttattg gtgcatcagc
     7141 ctttgtttgc tttttaaggt tcctttatgt tttaaaggga tttgaacaaa agacatcagg
     7201 agcttacaaa ggaaaaatag cttcattttg gttatgagat accagagtca gaaatgacat
     7261 tagattgtat agaaaagact tctaattgtg tgcttacttc ccacatgatt ataataaact
     7321 atatattaac aaccttggga tcgtactcag gttgtcaatt acacggatgc atctttcact
     7381 tttttctttc ccaagagtga gagaaagagt gaggttgtgc ttaaggcagt gtggaattct
     7441 acagaagctc ttcttggaaa aggagttcag gcacttgtgt tgtagactgc agtctgattc
     7501 tgttcttact tcctctcagc ataagggagc tttgaaaaga aaactcagac ttgtatccga
     7561 cttgaccaga agcaaaataa cttgatcatt gaagccacta tttctgtgta tttgatcaag
     7621 tcctcctctg gaatccaatg cagccatatt catatttcgg tctctcttaa tggaccttgc
     7681 tggaaagaac attctgtgct aagaaaatgg aaaataaacg tgagaaaact ttaagaatga
     7741 gccttcacac ctcctgcagc aggtgatagc tctgtacttc agagcttgtc tccaggttga
     7801 gaattacctg ttttccactc tgaggggatt agaaagatac tgttttaatg ggttataaaa
     7861 cttgtgtgaa gaagattggc cttctccacc tctcctgtga aataaattgt ttgaaaactc
     7921 tttgaagaga aa
//
