LOCUS       NM_153210               4185 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens ubiquitin specific peptidase 43 (USP43), transcript
            variant 1, mRNA.
ACCESSION   NM_153210 XM_945578
VERSION     NM_153210.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4185)
  AUTHORS   Zhao,Z., Lin,Z., Guo,X., Al-Danakh,A., He,H., Qin,H., Ma,C.,
            Zhang,N. and Tan,G.
  TITLE     Ubiquitin-Specific Protease 43 Impacts Pancreatic Ductal
            Adenocarcinoma Prognosis by Altering Its Proliferation and
            Infiltration of Surrounding Immune Cells
  JOURNAL   J Immunol Res 2023, 4311388 (2023)
   PUBMED   37050932
  REMARK    GeneRIF: Ubiquitin-Specific Protease 43 Impacts Pancreatic Ductal
            Adenocarcinoma Prognosis by Altering Its Proliferation and
            Infiltration of Surrounding Immune Cells.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4185)
  AUTHORS   Xue,Y., Li,M., Hu,J., Song,Y., Guo,W., Miao,C., Ge,D., Hou,Y.,
            Wang,X., Huang,X., Liu,T., Zhang,X. and Huang,Q.
  TITLE     Cav2.2-NFAT2-USP43 axis promotes invadopodia formation and breast
            cancer metastasis through cortactin stabilization
  JOURNAL   Cell Death Dis 13 (9), 812 (2022)
   PUBMED   36137995
  REMARK    GeneRIF: Cav2.2-NFAT2-USP43 axis promotes invadopodia formation and
            breast cancer metastasis through cortactin stabilization.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4185)
  AUTHORS   Sun,Q., Zhang,H., Zong,L., Julaiti,A., Jing,X. and Zhang,L.
  TITLE     Prognostic Value and Oncogenic Effects of Ubiquitin-Specific
            Protease 43 in Lung Squamous Cell Carcinoma
  JOURNAL   Tohoku J Exp Med 257 (2), 135-145 (2022)
   PUBMED   35321978
  REMARK    GeneRIF: Prognostic Value and Oncogenic Effects of
            Ubiquitin-Specific Protease 43 in Lung Squamous Cell Carcinoma.
REFERENCE   4  (bases 1 to 4185)
  AUTHORS   He,L., Liu,X., Yang,J., Li,W., Liu,S., Liu,X., Yang,Z., Ren,J.,
            Wang,Y., Shan,L., Guan,C., Pei,F., Lei,L., Zhang,Y., Yi,X.,
            Yang,X., Liang,J., Liu,R., Sun,L. and Shang,Y.
  TITLE     Imbalance of the reciprocally inhibitory loop between the
            ubiquitin-specific protease USP43 and EGFR/PI3K/AKT drives breast
            carcinogenesis
  JOURNAL   Cell Res 28 (9), 934-951 (2018)
   PUBMED   30135474
  REMARK    GeneRIF: study identifies USP43 to be an H2BK120 deubiquitinase and
            a potential tumor suppressor and reveals a reciprocally inhibitory
            loop between USP43 and EGFR/PI3K/AKT, whose imbalance drives breast
            carcinogenesis
REFERENCE   5  (bases 1 to 4185)
  AUTHORS   Quesada,V., Diaz-Perales,A., Gutierrez-Fernandez,A., Garabaya,C.,
            Cal,S. and Lopez-Otin,C.
  TITLE     Cloning and enzymatic analysis of 22 novel human ubiquitin-specific
            proteases
  JOURNAL   Biochem Biophys Res Commun 314 (1), 54-62 (2004)
   PUBMED   14715245
REFERENCE   6  (bases 1 to 4185)
  AUTHORS   Puente,X.S., Sanchez,L.M., Overall,C.M. and Lopez-Otin,C.
  TITLE     Human and mouse proteases: a comparative genomic approach
  JOURNAL   Nat Rev Genet 4 (7), 544-558 (2003)
   PUBMED   12838346
  REMARK    Review article
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC118755.7, BC144041.1, AJ583817.2 and BC039653.1.
            
            On Nov 23, 2018 this sequence version replaced NM_153210.4.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC144041.1, SRR1803612.125652.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA1968832
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000285199.12/ ENSP00000285199.6
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-20                AC118755.7         2555-2574           c
            21-1246             BC144041.1         1-1226
            1247-1247           AJ583817.2         1134-1134
            1248-3531           BC144041.1         1228-3511
            3532-3608           BC039653.1         1474-1550
            3609-4185           BC039653.1         1553-2129
FEATURES             Location/Qualifiers
     source          1..4185
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17p13.1"
     gene            1..4185
                     /gene="USP43"
                     /note="ubiquitin specific peptidase 43"
                     /db_xref="GeneID:124739"
                     /db_xref="HGNC:HGNC:20072"
     exon            1..620
                     /gene="USP43"
                     /inference="alignment:Splign:2.1.0"
     CDS             117..3488
                     /gene="USP43"
                     /EC_number="3.4.19.12"
                     /note="isoform 1 is encoded by transcript variant 1;
                     ubiquitin specific protease 43; ubiquitin
                     carboxyl-terminal hydrolase 43; ubiquitin thioesterase 43;
                     deubiquitinating enzyme 43; ubiquitin-specific-processing
                     protease 43; ubiquitin thiolesterase 43"
                     /codon_start=1
                     /product="ubiquitin carboxyl-terminal hydrolase 43 isoform
                     1"
                     /protein_id="NP_694942.3"
                     /db_xref="CCDS:CCDS45610.1"
                     /db_xref="GeneID:124739"
                     /db_xref="HGNC:HGNC:20072"
                     /translation="MDLGPGDAAGGGPLAPRPRRRRSLRRLFSRFLLALGSRSRPGDS
                     PPRPQPGHCDGDGEGGFACAPGPVPAAPGSPGEERPPGPQPQLQLPAGDGARPPGAQG
                     LKNHGNTCFMNAVVQCLSNTDLLAEFLALGRYRAAPGRAEVTEQLAALVRALWTREYT
                     PQLSAEFKNAVSKYGSQFQGNSQHDALEFLLWLLDRVHEDLEGSSRGPVSEKLPPEAT
                     KTSENCLSPSAQLPLGQSFVQSHFQAQYRSSLTCPHCLKQSNTFDPFLCVSLPIPLRQ
                     TRFLSVTLVFPSKSQRFLRVGLAVPILSTVAALRKMVAEEGGVPADEVILVELYPSGF
                     QRSFFDEEDLNTIAEGDNVYAFQVPPSPSQGTLSAHPLGLSASPRLAAREGQRFSLSL
                     HSESKVLILFCNLVGSGQQASRFGPPFLIREDRAVSWAQLQQSILSKVRHLMKSEAPV
                     QNLGSLFSIRVVGLSVACSYLSPKDSRPLCHWAVDRVLHLRRPGGPPHVKLAVEWDSS
                     VKERLFGSLQEERAQDADSVWQQQQAHQQHSCTLDECFQFYTKEEQLAQDDAWKCPHC
                     QVLQQGMVKLSLWTLPDILIIHLKRFCQVGERRNKLSTLVKFPLSGLNMAPHVAQRST
                     SPEAGLGPWPSWKQPDCLPTSYPLDFLYDLYAVCNHHGNLQGGHYTAYCRNSLDGQWY
                     SYDDSTVEPLREDEVNTRGAYILFYQKRNSIPPWSASSSMRGSTSSSLSDHWLLRLGS
                     HAGSTRGSLLSWSSAPCPSLPQVPDSPIFTNSLCNQEKGGLEPRRLVRGVKGRSISMK
                     APTTSRAKQGPFKTMPLRWSFGSKEKPPGASVELVEYLESRRRPRSTSQSIVSLLTGT
                     AGEDEKSASPRSNVALPANSEDGGRAIERGPAGVPCPSAQPNHCLAPGNSDGPNTARK
                     LKENAGQDIKLPRKFDLPLTVMPSVEHEKPARPEGQKAMNWKESFQMGSKSSPPSPYM
                     GFSGNSKDSRRGTSELDRPLQGTLTLLRSVFRKKENRRNERAEVSPQVPPVSLVSGGL
                     SPAMDGQAPGSPPALRIPEGLARGLGSRLERDVWSAPSSLRLPRKASRAPRGSALGMS
                     QRTVPGEQASYGTFQRVKYHTLSLGRKKTLPESSF"
     exon            621..752
                     /gene="USP43"
                     /inference="alignment:Splign:2.1.0"
     exon            753..856
                     /gene="USP43"
                     /inference="alignment:Splign:2.1.0"
     exon            857..949
                     /gene="USP43"
                     /inference="alignment:Splign:2.1.0"
     exon            950..1085
                     /gene="USP43"
                     /inference="alignment:Splign:2.1.0"
     exon            1086..1221
                     /gene="USP43"
                     /inference="alignment:Splign:2.1.0"
     exon            1222..1357
                     /gene="USP43"
                     /inference="alignment:Splign:2.1.0"
     exon            1358..1469
                     /gene="USP43"
                     /inference="alignment:Splign:2.1.0"
     exon            1470..1573
                     /gene="USP43"
                     /inference="alignment:Splign:2.1.0"
     exon            1574..1651
                     /gene="USP43"
                     /inference="alignment:Splign:2.1.0"
     exon            1652..1778
                     /gene="USP43"
                     /inference="alignment:Splign:2.1.0"
     exon            1779..2127
                     /gene="USP43"
                     /inference="alignment:Splign:2.1.0"
     exon            2128..2286
                     /gene="USP43"
                     /inference="alignment:Splign:2.1.0"
     exon            2287..2451
                     /gene="USP43"
                     /inference="alignment:Splign:2.1.0"
     exon            2452..4185
                     /gene="USP43"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4165..4170
                     /regulatory_class="polyA_signal_sequence"
                     /gene="USP43"
                     /note="hexamer: AATAAA"
     polyA_site      4185
                     /gene="USP43"
                     /note="major polyA site"
ORIGIN      
        1 acacctggcc cgcaggtagc cggcaccagg agccttagag aagctgtagg gcctgctggc
       61 cgctcgtccg cctcgcgccc gggggctccg cgcctggagc tgcgccggcg gcagccatgg
      121 acctgggccc cggggacgcg gcaggagggg gaccgctcgc gccccggccc cgccgccgcc
      181 gctccctgcg ccgcctgttc agccgcttcc tgctggcgct gggcagccgc tcacgccccg
      241 gggactcacc gccccggccc cagccgggac actgtgatgg cgacggtgag gggggcttcg
      301 cctgcgcccc gggcccagtt ccagcggccc ccgggagccc cggggaggaa cgcccgcccg
      361 gaccccagcc ccagctccag ctccccgccg gcgatggggc gcggccgccg ggcgctcagg
      421 gcttgaagaa ccacggcaac acctgtttca tgaacgcggt ggtgcagtgt ctcagcaaca
      481 ccgacctgct ggccgagttc ctggcgctgg ggcgctaccg ggcggctccg ggccgcgccg
      541 aggtcaccga gcagctggcg gcgctggtgc gcgcgctctg gactcgcgaa tacacgcccc
      601 aactttccgc ggagttcaag aatgcagttt ccaagtacgg ctctcagttc caaggcaatt
      661 cccagcacga cgccctggaa ttcctgctct ggttgctgga tcgtgtacat gaggacctgg
      721 agggttcatc ccgagggccg gtgtcggaga agcttccgcc tgaagccact aaaacctctg
      781 agaactgcct gtcaccatca gctcagcttc ctctaggtca aagctttgtg caaagccact
      841 ttcaagcaca atatagatct tccttgactt gtccccactg cctgaaacag agcaacacct
      901 ttgatccttt cctgtgtgtg tccctaccta tccccttgcg ccagacgagg ttcttgagtg
      961 tcaccttggt cttcccctct aagagccagc ggttcctgcg ggttggcctg gccgtgccga
     1021 tcctcagcac agtggcagcc ctgaggaaga tggttgcaga ggaaggaggc gtccctgcag
     1081 atgaggtgat cttggttgaa ctgtatccca gtggattcca gcggtctttc tttgatgaag
     1141 aggacctgaa taccatcgca gagggagata atgtgtatgc ctttcaagtt cctccctcac
     1201 ccagccaggg gactctctca gctcatccac tgggtctgtc ggcctcccca cgcctggcag
     1261 cccgtgaggg ccagcgattc tccctctctc tccacagtga gagcaaggtg ctaatcctct
     1321 tctgtaactt ggtggggtca gggcagcagg ctagcaggtt tgggccaccc ttcctgataa
     1381 gggaagacag agctgtttcc tgggcccagc tccagcagtc tatcctcagc aaggtccgcc
     1441 atcttatgaa gagtgaggcc cctgtacaga acctggggtc tctgttctcc atccgtgttg
     1501 tgggactctc tgtggcctgc agctatttgt ctccgaagga cagtcggccc ctctgtcact
     1561 gggcagttga cagggttttg catctcagga ggccaggagg ccctccacat gtcaagctgg
     1621 cggtggagtg ggatagctct gtcaaggagc gcctgttcgg gagcctccag gaggagcgag
     1681 cgcaggatgc cgacagtgtg tggcagcagc agcaggcgca tcagcagcac agctgtacct
     1741 tggatgaatg ttttcagttc tacaccaagg aggagcagct ggcccaggat gacgcctgga
     1801 agtgtcctca ctgccaagtc ctgcagcagg ggatggtgaa gctgagtttg tggacgctgc
     1861 ctgacatcct catcatccac ctcaaaaggt tctgccaggt gggcgagaga agaaacaagc
     1921 tctccacgct ggtgaagttt ccgctctctg gactcaacat ggctccccat gtggcccaga
     1981 gaagcaccag ccctgaggca ggactgggcc cctggccttc ctggaagcag ccggactgcc
     2041 tgcccaccag ttacccgctg gacttcctgt acgacctgta tgccgtctgc aaccaccatg
     2101 gcaacctgca aggtgggcat tacacagcct actgccggaa ctctctggat ggccagtggt
     2161 acagttatga tgacagcacg gtggaaccgc ttcgagaaga tgaggtcaac accagagggg
     2221 cttatatcct gttctatcag aagcggaaca gcatccctcc ctggtcagcc agcagctcca
     2281 tgagaggctc taccagctcc tccctgtctg atcactggct cttacggctc gggagccacg
     2341 ctggcagcac aaggggaagc ctgctgtcct ggagctctgc cccctgcccc tccctgcccc
     2401 aggttcctga ctctcccatc ttcaccaaca gcctctgcaa tcaggaaaag ggagggttgg
     2461 agcccaggcg tttggtacgg ggcgtgaaag gcagaagcat tagcatgaag gcacccacca
     2521 cttcccgagc caagcaggga ccattcaaga ccatgcctct gcggtggtcc tttggatcca
     2581 aggagaaacc accaggtgcc tccgtcgagt tggtggagta cttggaatcc agacgaagac
     2641 ctcggtccac gagccagtcc attgtgtcgc tgttgacggg cactgcgggt gaggatgaga
     2701 agtcagcatc gccgaggtcc aacgtcgccc ttcctgctaa cagcgaagat ggtgggcggg
     2761 ccattgaaag aggtccagcc ggggtgccct gtccctcggc tcaacccaac cactgtctgg
     2821 cccctggaaa ctcagatggt ccaaacacag caaggaaact caaggaaaat gcagggcagg
     2881 acatcaagct tcccagaaag tttgacctgc ctctcactgt gatgccttca gtggagcatg
     2941 agaaaccagc tcgaccggag ggccagaagg ccatgaactg gaaggagagc ttccagatgg
     3001 gaagcaaaag cagcccaccc tccccctata tgggattctc tggaaacagc aaagacagtc
     3061 gccgaggcac ctctgagcta gacagacccc tgcaggggac actcaccctt ctgaggtccg
     3121 tgtttcggaa gaaggagaac aggaggaatg agagggcaga ggtctctcca caggtgcccc
     3181 ccgtctccct ggtgagtggc gggctgagcc ctgccatgga cgggcaggct ccaggctcac
     3241 ctcctgccct caggatccca gagggcctgg ccaggggcct gggcagccgg ctcgagaggg
     3301 atgtctggtc agcccccagc tctctccgcc tccctcgtaa agccagcagg gccccgagag
     3361 gcagtgcact gggcatgtca caaaggactg ttccagggga gcaggcttct tatggcacct
     3421 ttcagagagt caaatatcac actctttctt taggtcgaaa gaaaacctta ccggagtcca
     3481 gcttttgatg gagcgtgtca gtattgtgtg acgctggcat tcttgggact ttgccaagca
     3541 actgtaggca gctcatgttg agaatgggtt tccaggaaac ccgttgtctt gtaatctcta
     3601 aaaaaaaatt tttttttttt tgtggtgggg ggtctccata tctagacttc caacacccaa
     3661 ggtccatata acccaaggtc gaaaaccttc ctgcatcatt gggtgctttg ctacagtttg
     3721 gccactagag gatgctattg ggtcagtatt accagtttca gggcaagaac tgatatttac
     3781 taaagagttt tggatgtggg caaacaagat gaggctggtt taataagaat cttcaatgtc
     3841 atgtcaaata ctgtcaatgg cttttccttt ttctttcttt ttttttttta aattgtggac
     3901 ttaaagaaaa atattttatt tttaatgctt ttctgggata agcattaaag atgccaaaaa
     3961 gaaaaaaaaa acaaaagaat gatagtgatg gtaaggcaag attctagcaa agagagatgg
     4021 gagataaatg gctgagagtt caggtgaata tttaatatat taaaaattgt attaaagttt
     4081 ttcaaggtat tttaaaaata actattttga tactagaaaa aaagtccatt ttttaattta
     4141 aatatgagat ctatgtacaa ttttaataaa atcctgtcca tgaaa
//
