LOCUS       NM_032172               5090 bp    mRNA    linear   PRI 13-SEP-2024
DEFINITION  Homo sapiens ubiquitin specific peptidase 42 (USP42), transcript
            variant 2, mRNA.
ACCESSION   NM_032172 XM_374396 XM_499256
VERSION     NM_032172.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5090)
  AUTHORS   Pan,Y., Gu,H., Xiao,H., Zhao,L., Tang,Y. and Ge,W.
  TITLE     [Ubiquitin-specific protease 42 regulates osteogenic
            differentiation of human adipose-derived stem cells]
  JOURNAL   Beijing Da Xue Xue Bao Yi Xue Ban 56 (1), 9-16 (2024)
   PUBMED   38318890
  REMARK    GeneRIF: [Ubiquitin-specific protease 42 regulates osteogenic
            differentiation of human adipose-derived stem cells].
REFERENCE   2  (bases 1 to 5090)
  AUTHORS   Teixeira,E., Fernandes,C., Bungardean,M., Paula,A.D.C., Lima,R.T.,
            Batista,R., Vinagre,J., Sobrinho-Simoes,M., Maximo,V. and Soares,P.
  TITLE     Investigating USP42 Mutation as Underlying Cause of Familial
            Non-Medullary Thyroid Carcinoma
  JOURNAL   Int J Mol Sci 25 (3), 1522 (2024)
   PUBMED   38338801
  REMARK    GeneRIF: Investigating USP42 Mutation as Underlying Cause of
            Familial Non-Medullary Thyroid Carcinoma.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5090)
  AUTHORS   Mishra,R., Kumawat,K.L., Basu,A. and Banerjea,A.C.
  TITLE     Japanese Encephalitis Virus infection increases USP42 to stabilize
            TRIM21 and OAS1 for neuroinflammatory and anti-viral response in
            human microglia
  JOURNAL   Virology 573, 131-140 (2022)
   PUBMED   35779335
  REMARK    GeneRIF: Japanese Encephalitis Virus infection increases USP42 to
            stabilize TRIM21 and OAS1 for neuroinflammatory and anti-viral
            response in human microglia.
REFERENCE   4  (bases 1 to 5090)
  AUTHORS   Yu,J., Shen,W., Xu,J., Gong,B., Gao,B. and Zhu,J.
  TITLE     circUSP42 Is Downregulated in Triple-Negative Breast Cancer and
            Associated With Poor Prognosis
  JOURNAL   Technol Cancer Res Treat 19, 1533033820950827 (2020)
   PUBMED   32938310
  REMARK    GeneRIF: circUSP42 Is Downregulated in Triple-Negative Breast
            Cancer and Associated With Poor Prognosis.
REFERENCE   5  (bases 1 to 5090)
  AUTHORS   Hou,K., Zhu,Z., Wang,Y., Zhang,C., Yu,S., Zhu,Q. and Yan,B.
  TITLE     Overexpression and Biological Function of Ubiquitin-Specific
            Protease 42 in Gastric Cancer
  JOURNAL   PLoS One 11 (3), e0152997 (2016)
   PUBMED   27030989
  REMARK    GeneRIF: USP42 overexpression could be a potential prognostic
            marker for GC, regulate the survival and invasive properties of GC,
            and may represent a novel therapeutic molecular target for this
            tumor.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 5090)
  AUTHORS   Masetti,R., Togni,M., Astolfi,A., Pigazzi,M., Indio,V., Rivalta,B.,
            Manara,E., Rutella,S., Basso,G., Pession,A. and Locatelli,F.
  TITLE     Whole transcriptome sequencing of a paediatric case of de novo
            acute myeloid leukaemia with del(5q) reveals RUNX1-USP42 and
            PRDM16-SKI fusion transcripts
  JOURNAL   Br J Haematol 166 (3), 449-452 (2014)
   PUBMED   24673627
  REMARK    GeneRIF: we report, for the first time, the identification of a
            RUNX1-USP42 fusion transcript detected at diagnosis in a child with
            AML and del(5).
            Review article
REFERENCE   7  (bases 1 to 5090)
  AUTHORS   Hock,A.K., Vigneron,A.M., Carter,S., Ludwig,R.L. and Vousden,K.H.
  TITLE     Regulation of p53 stability and function by the deubiquitinating
            enzyme USP42
  JOURNAL   EMBO J 30 (24), 4921-4930 (2011)
   PUBMED   22085928
  REMARK    GeneRIF: the function of USP42 is required to allow the rapid
            activation of p53-dependent transcription and a p53-dependent
            cell-cycle arrest in response to stress.
            Publication Status: Online-Only
REFERENCE   8  (bases 1 to 5090)
  AUTHORS   Beausoleil,S.A., Jedrychowski,M., Schwartz,D., Elias,J.E.,
            Villen,J., Li,J., Cohn,M.A., Cantley,L.C. and Gygi,S.P.
  TITLE     Large-scale characterization of HeLa cell nuclear phosphoproteins
  JOURNAL   Proc Natl Acad Sci U S A 101 (33), 12130-12135 (2004)
   PUBMED   15302935
REFERENCE   9  (bases 1 to 5090)
  AUTHORS   Quesada,V., Diaz-Perales,A., Gutierrez-Fernandez,A., Garabaya,C.,
            Cal,S. and Lopez-Otin,C.
  TITLE     Cloning and enzymatic analysis of 22 novel human ubiquitin-specific
            proteases
  JOURNAL   Biochem Biophys Res Commun 314 (1), 54-62 (2004)
   PUBMED   14715245
REFERENCE   10 (bases 1 to 5090)
  AUTHORS   Puente,X.S., Sanchez,L.M., Overall,C.M. and Lopez-Otin,C.
  TITLE     Human and mouse proteases: a comparative genomic approach
  JOURNAL   Nat Rev Genet 4 (7), 544-558 (2003)
   PUBMED   12838346
  REMARK    Review article
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DB457216.2, BC132862.1, BF725643.1, AA936550.1 and BM995466.1.
            
            On Jun 2, 2019 this sequence version replaced NM_032172.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC132862.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000306177.10/ ENSP00000301962.5
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-73                DB457216.2         58-130
            74-4166             BC132862.1         1-4093
            4167-4385           BF725643.1         294-512
            4386-4717           AA936550.1         132-463
            4718-5090           BM995466.1         16-388              c
FEATURES             Location/Qualifiers
     source          1..5090
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7p22.1"
     gene            1..5090
                     /gene="USP42"
                     /note="ubiquitin specific peptidase 42"
                     /db_xref="GeneID:84132"
                     /db_xref="HGNC:HGNC:20068"
                     /db_xref="MIM:620946"
     exon            1..84
                     /gene="USP42"
                     /inference="alignment:Splign:2.1.0"
     exon            85..334
                     /gene="USP42"
                     /inference="alignment:Splign:2.1.0"
     CDS             94..4044
                     /gene="USP42"
                     /EC_number="3.4.19.12"
                     /note="isoform 2 is encoded by transcript variant 2;
                     ubiquitin specific protease 42; ubiquitin
                     carboxyl-terminal hydrolase 42; ubiquitin thioesterase 42;
                     deubiquitinating enzyme 42; ubiquitin-specific-processing
                     protease 42; ubiquitin thiolesterase 42"
                     /codon_start=1
                     /product="ubiquitin carboxyl-terminal hydrolase 42 isoform
                     2"
                     /protein_id="NP_115548.1"
                     /db_xref="CCDS:CCDS47535.1"
                     /db_xref="GeneID:84132"
                     /db_xref="HGNC:HGNC:20068"
                     /db_xref="MIM:620946"
                     /translation="MTIVDKASESSDPSAYQNQPGSSEAVSPGDMDAGSASWGAVSSL
                     NDVSNHTLSLGPVPGAVVYSSSSVPDKSKPSPQKDQALGDGIAPPQKVLFPSEKICLK
                     WQQTHRVGAGLQNLGNTCFANAALQCLTYTPPLANYMLSHEHSKTCHAEGFCMMCTMQ
                     AHITQALSNPGDVIKPMFVINEMRRIARHFRFGNQEDAHEFLQYTVDAMQKACLNGSN
                     KLDRHTQATTLVCQIFGGYLRSRVKCLNCKGVSDTFDPYLDITLEIKAAQSVNKALEQ
                     FVKPEQLDGENSYKCSKCKKMVPASKRFTIHRSSNVLTLSLKRFANFTGGKIAKDVKY
                     PEYLDIRPYMSQPNGEPIVYVLYAVLVHTGFNCHAGHYFCYIKASNGLWYQMNDSIVS
                     TSDIRSVLSQQAYVLFYIRSHDVKNGGELTHPTHSPGQSSPRPVISQRVVTNKQAAPG
                     FIGPQLPSHMIKNPPHLNGTGPLKDTPSSSMSSPNGNSSVNRASPVNASASVQNWSVN
                     RSSVIPEHPKKQKITISIHNKLPVRQCQSQPNLHSNSLENPTKPVPSSTITNSAVQST
                     SNASTMSVSSKVTKPIPRSESCSQPVMNGKSKLNSSVLVPYGAESSEDSDEESKGLGK
                     ENGIGTIVSSHSPGQDAEDEEATPHELQEPMTLNGANSADSDSDPKENGLAPDGASCQ
                     GQPALHSENPFAKANGLPGKLMPAPLLSLPEDKILETFRLSNKLKGSTDEMSAPGAER
                     GPPEDRDAEPQPGSPAAESLEEPDAAAGLSSTKKAPPPRDPGTPATKEGAWEAMAVAP
                     EEPPPSAGEDIVGDTAPPDLCDPGSLTGDASPLSQDAKGMIAEGPRDSALAEAPEGLS
                     PAPPARSEEPCEQPLLVHPSGDHARDAQDPSQSLGAPEAAERPPAPVLDMAPAGHPEG
                     DAEPSPGERVEDAAAPKAPGPSPAKEKIGSLRKVDRGHYRSRRERSSSGEPARESRSK
                     TEGHRHRRRRTCPRERDRQDRHAPEHHPGHGDRLSPGERRSLGRCSHHHSRHRSGVEL
                     DWVRHHYTEGERGWGREKFYPDRPRWDRCRYYHDRYALYAARDWKPFHGGREHERAGL
                     HERPHKDHNRGRRGCEPARERERHRPSSPRAGAPHALAPHPDRFSHDRTALVAGDNCN
                     LSDRFHEHENGKSRKRRHDSVENSDSHVEKKARRSEQKDPLEEPKAKKHKKSKKKKKS
                     KDKHRDRDSRHQQDSDLSAACSDADLHRHKKKKKKKKRHSRKSEDFVKDSELHLPRVT
                     SLETVAQFRRAQGGFPLSGGPPLEGVGPFREKTKHLRMESRDDRCRLFEYGQGD"
     exon            335..535
                     /gene="USP42"
                     /inference="alignment:Splign:2.1.0"
     exon            536..646
                     /gene="USP42"
                     /inference="alignment:Splign:2.1.0"
     exon            647..749
                     /gene="USP42"
                     /inference="alignment:Splign:2.1.0"
     exon            750..817
                     /gene="USP42"
                     /inference="alignment:Splign:2.1.0"
     exon            818..888
                     /gene="USP42"
                     /inference="alignment:Splign:2.1.0"
     exon            889..971
                     /gene="USP42"
                     /inference="alignment:Splign:2.1.0"
     exon            972..1083
                     /gene="USP42"
                     /inference="alignment:Splign:2.1.0"
     exon            1084..1224
                     /gene="USP42"
                     /inference="alignment:Splign:2.1.0"
     exon            1225..1325
                     /gene="USP42"
                     /inference="alignment:Splign:2.1.0"
     exon            1326..1479
                     /gene="USP42"
                     /inference="alignment:Splign:2.1.0"
     exon            1480..2199
                     /gene="USP42"
                     /inference="alignment:Splign:2.1.0"
     exon            2200..2294
                     /gene="USP42"
                     /inference="alignment:Splign:2.1.0"
     exon            2295..3734
                     /gene="USP42"
                     /inference="alignment:Splign:2.1.0"
     exon            3735..4036
                     /gene="USP42"
                     /inference="alignment:Splign:2.1.0"
     exon            4037..4080
                     /gene="USP42"
                     /inference="alignment:Splign:2.1.0"
     exon            4081..5090
                     /gene="USP42"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4726..4731
                     /regulatory_class="polyA_signal_sequence"
                     /gene="USP42"
                     /note="hexamer: ATTACA"
     polyA_site      4746
                     /gene="USP42"
                     /note="major polyA site"
     regulatory      5041..5046
                     /regulatory_class="polyA_signal_sequence"
                     /gene="USP42"
                     /note="hexamer: AATATA"
     polyA_site      5090
                     /gene="USP42"
                     /note="major polyA site"
ORIGIN      
        1 attgtccccc gccgggcggc tgggctgtgt gcggcggcgg cggcggcggc cgagggggat
       61 ggagcgagcg ccgagccggg tcagagttga acaatgacca tagttgacaa agcttctgaa
      121 tcttcagacc catcagccta tcagaatcag cctggcagct ccgaggcagt ctcacctgga
      181 gacatggatg caggttctgc cagctggggt gctgtgtctt cattgaatga tgtgtcaaat
      241 cacacacttt ctttaggacc agtacctggt gctgtagttt attcgagttc atctgtacct
      301 gataaatcaa aaccatcacc acaaaaggat caagccctag gtgatggcat cgctcctcca
      361 cagaaagttc ttttcccatc tgagaagatt tgtcttaagt ggcaacaaac tcatagagtt
      421 ggagctgggc tccagaattt gggcaatacc tgttttgcca atgcagcact gcagtgttta
      481 acctacacac cacctcttgc caattacatg ctatcacatg aacactccaa aacatgtcat
      541 gcagaaggct tttgtatgat gtgtacaatg caagcacata ttacccaggc actcagtaat
      601 cctggggacg ttattaaacc aatgtttgtc atcaatgaga tgcggcgtat agctaggcac
      661 ttccgttttg gaaaccaaga agatgcccat gaattccttc aatacactgt tgatgctatg
      721 cagaaagcat gcttgaatgg cagcaataaa ttagacagac acacccaggc caccactctt
      781 gtttgtcaga tatttggagg atacctaaga tctagagtca aatgtttaaa ttgcaagggc
      841 gtttcagata cttttgatcc atatcttgat ataacattgg agataaaggc tgctcagagt
      901 gtcaacaagg cattggagca gtttgtgaag ccggaacagc ttgatggaga aaactcgtac
      961 aagtgcagca agtgtaaaaa gatggttcca gcttcaaaga ggttcactat ccatagatcc
     1021 tctaatgttc ttacactttc tctgaaacgt tttgcaaatt ttaccggtgg aaaaattgct
     1081 aaggatgtga aataccctga gtatcttgat attcggccat atatgtctca acccaacgga
     1141 gagccaattg tctacgtctt gtatgcagtg ctggtccaca ctggttttaa ttgccatgct
     1201 ggccattact tctgctacat aaaagctagc aatggcctct ggtatcaaat gaatgactcc
     1261 attgtatcta ccagtgatat tagatcggta ctcagccaac aagcctatgt gctcttttat
     1321 atcaggtccc atgatgtgaa aaatggaggt gaacttactc atcccaccca tagccccggc
     1381 cagtcctctc cccgccccgt catcagtcag cgggttgtca ccaacaaaca ggctgcgcca
     1441 ggctttatcg gaccacagct tccctctcac atgataaaga atccacctca cttaaatggg
     1501 actggaccat tgaaagacac gccaagcagt tccatgtcga gtcctaacgg gaattccagt
     1561 gtcaacaggg ctagtcctgt taatgcttca gcttctgtcc aaaactggtc agttaatagg
     1621 tcctcagtga tcccagaaca tcctaagaaa caaaaaatta caatcagtat tcacaacaag
     1681 ttgcctgttc gccagtgtca gtctcaacct aaccttcata gtaattcttt ggagaaccct
     1741 accaagcccg ttccctcttc taccattacc aattctgcag tacagtctac ctcgaacgca
     1801 tctacgatgt cagtttctag taaagtaaca aaaccgatcc cccgcagtga atcctgctcc
     1861 cagcccgtga tgaatggcaa atccaagctg aactccagcg tgctggtgcc ctatggcgcc
     1921 gagtcctctg aggactctga cgaggagtca aaggggctgg gcaaggagaa tgggattggt
     1981 acgattgtga gctcccactc tcccggccaa gatgccgaag atgaggaggc cactccgcac
     2041 gagcttcaag aacccatgac cctaaacggt gctaatagtg cagacagcga cagtgacccg
     2101 aaagaaaacg gcctagcgcc tgatggtgcc agctgccaag gccagcctgc cctgcactca
     2161 gaaaatccct ttgctaaggc aaacggtctt cctggaaagt tgatgcctgc tcctttgctg
     2221 tctctcccag aagacaaaat cttagagacc ttcaggctta gcaacaaact gaaaggctcg
     2281 acggatgaaa tgagtgcacc tggagcagag aggggccctc ccgaggaccg cgacgccgag
     2341 cctcagcctg gcagccccgc cgccgaatcc ctggaggagc cagatgcggc cgccggcctc
     2401 agcagcacca agaaggctcc gccgccccgc gatcccggca cccccgctac caaagaaggc
     2461 gcctgggagg ccatggccgt cgcccccgag gagcctccgc ccagcgccgg cgaggacatc
     2521 gtgggggaca cagcaccccc tgacctgtgt gatcccggga gcttaacagg cgatgcgagc
     2581 ccgttgtccc aggacgcaaa ggggatgatc gcggagggcc cgcgggactc ggcgttggcg
     2641 gaagccccgg aagggttgag tccggctccg cctgcgcggt cggaggagcc ctgcgagcag
     2701 ccactccttg ttcaccccag cggggaccac gcccgggacg ctcaggaccc atcccagagc
     2761 ttgggcgcac ccgaggccgc agagcggccg ccagctcctg tgctggacat ggccccggcc
     2821 ggtcacccgg aaggggacgc tgagcctagc cccggcgaga gggtcgagga cgccgcggcg
     2881 ccgaaagccc caggcccttc cccagcgaag gagaaaatcg gcagcctcag aaaggtggac
     2941 cgaggccact accgcagccg gagagagcgc tcgtccagcg gggagcccgc cagagagagc
     3001 aggagcaaga ctgagggcca ccgtcaccgg cggcgccgca cctgcccccg ggagcgcgac
     3061 cgccaggacc gccacgcccc ggagcaccac cccggccacg gcgacaggct cagccctggc
     3121 gagcgccgct ctctgggcag gtgcagtcac caccactccc gacaccggag cggggtggag
     3181 ctggactggg tcagacacca ctacaccgag ggcgagcgtg gctggggccg ggagaagttc
     3241 taccccgaca ggccgcgctg ggacaggtgc cggtactacc atgacaggta cgccctgtac
     3301 gctgcccggg actggaagcc cttccacggc ggccgcgagc acgagcgggc cgggctgcac
     3361 gagcggccgc acaaggacca caaccggggc cgtaggggct gcgagccggc ccgggagagg
     3421 gagcggcacc gccccagcag cccccgcgca ggcgcgcccc acgccctcgc cccgcacccc
     3481 gaccgcttct cccacgacag aactgcactt gtagccggag acaactgtaa cctctctgat
     3541 cggtttcacg aacacgaaaa tggaaagtcc cggaaacgga gacacgacag tgtggagaac
     3601 agtgacagtc atgttgaaaa gaaagcccgg aggagcgaac agaaggatcc tctagaagag
     3661 cctaaagcaa agaagcacaa aaaatcaaag aagaaaaaga aatccaaaga caaacaccga
     3721 gaccgcgact ccaggcatca gcaggactca gacctctcag cagcgtgctc tgacgctgac
     3781 ctccacagac acaaaaaaaa gaagaagaaa aagaagagac attcaagaaa atcagaggac
     3841 tttgttaaag attcagaact gcacttaccc agggtcacca gcttggagac tgtcgcccag
     3901 ttccggagag cccagggtgg ctttcctctc tctggtggcc cgcctctgga aggcgtcgga
     3961 cctttccgtg agaaaacgaa acacttacgg atggaaagca gggatgacag gtgtcgtctc
     4021 tttgagtatg gccagggtga ttgaaaactc agcctcaaaa caaaaaattc actagttatg
     4081 attcaacgcg ttcaacagaa gccatcccca gcccagctta aattataaag atagacaata
     4141 actctgttcc aatctgcgtg gtgcttcttt agtaaatact gtacagattt taccatggag
     4201 aacttttttt ttagttttta ccttttctta attaccctta ttccgaatgg acgaacactt
     4261 tctaccactg ctgaccattg taaaataccg tgtatataaa tcccattgaa ataatgccct
     4321 ggaatagaac atctcaaatg ctgcttaatt acagactcag gtcgattact tgtatttcat
     4381 gtaatgttcc tccaagttag acatctggtg caagaccaac cgggagacca tggaattgtc
     4441 aaaagtacaa actgacagtg tgtatattta atttaaagac ttatttaaaa actcacaagc
     4501 tctcacctag actttggaga gcagtctgtt ttctgtaatg tctgatacta gaaactaatt
     4561 tgcttatttt agttgtattc aagatttgaa gatgtatttt atagacaagt tctgtttttg
     4621 aactttgtgg aactgttcca atcaatcaat ttcccagtta tgatgagtat ttacattatg
     4681 aatgtataac ccagacatga tttgtaaagc cgacagtatg tttctattac acaacacttt
     4741 ttgatacagc gtctcttgtc ttcactgata ctggagtctc cgttgtctgc ttggtccctt
     4801 cgagtttcta gttacagaca caatcatact gtgattttat ttttaatatg gatatgctat
     4861 caaactgtga tacacttata attcactggt cctgcatcag gagatggagt ggggaaaact
     4921 gtatttaata cagtttgtat ctgaataatc tgtatggttt atacagtttg tgttgttcag
     4981 agatgtttaa agtttgatct ttgtttttct aaagattaaa aaagcacttg ccccactgta
     5041 aatatacagc atgtaaaatt tctatagtat ataaatggca gcaaatcaca
//
