LOCUS       NM_001365479            5695 bp    mRNA    linear   PRI 02-MAY-2024
DEFINITION  Homo sapiens ubiquitin specific peptidase 40 (USP40), transcript
            variant 1, mRNA.
ACCESSION   NM_001365479 XM_017004426
VERSION     NM_001365479.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5695)
  AUTHORS   Mo,H., Li,R., Yang,N., Han,J., Xiao,X., Zhang,Y., Xiao,Z., Jiao,L.,
            Xu,Q. and Tu,K.
  TITLE     USP40 promotes hepatocellular carcinoma progression through a
            YAP/USP40 positive feedback loop
  JOURNAL   Cancer Lett 589, 216832 (2024)
   PUBMED   38537774
  REMARK    GeneRIF: USP40 promotes hepatocellular carcinoma progression
            through a YAP/USP40 positive feedback loop.
REFERENCE   2  (bases 1 to 5695)
  AUTHORS   Wu,Q., Qiu,Y., Guo,J., Yuan,Z., Yang,Y., Zhu,Q., Zhang,Z., Guo,J.,
            Wu,Y., Zhang,J., Huang,D., Tu,K. and Hu,X.
  TITLE     USP40 promotes hepatocellular carcinoma cell proliferation,
            migration and stemness by deubiquitinating and stabilizing Claudin1
  JOURNAL   Biol Direct 19 (1), 13 (2024)
   PUBMED   38308285
  REMARK    GeneRIF: USP40 promotes hepatocellular carcinoma cell
            proliferation, migration and stemness by deubiquitinating and
            stabilizing Claudin1.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5695)
  AUTHORS   An,W., Yao,S., Sun,X., Hou,Z., Lin,Y., Su,L. and Liu,X.
  TITLE     Glucocorticoid modulatory element-binding protein 1 (GMEB1)
            interacts with the de-ubiquitinase USP40 to stabilize CFLARL and
            inhibit apoptosis in human non-small cell lung cancer cells
  JOURNAL   J Exp Clin Cancer Res 38 (1), 181 (2019)
   PUBMED   31046799
  REMARK    GeneRIF: Our findings show the de-ubiquitinase USP40 regulates the
            ubiquitination and degradation of CFLARL; and GMEB1 acts as a
            bridge protein for USP40 and CFLARL. Mechanistically, we found
            GMEB1 inhibits the activation of CASP8 by modulating ubiquitination
            and degradation of CFLARL
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 5695)
  AUTHORS   Zhao,B., Song,W., Chen,Y.P., Huang,R., Chen,K., Cao,B., Yang,Y. and
            Shang,H.F.
  TITLE     Association analysis of single-nucleotide polymorphisms of USP24
            and USP40 with Parkinson's disease in the Han Chinese population
  JOURNAL   Eur Neurol 68 (3), 181-184 (2012)
   PUBMED   22923019
  REMARK    GeneRIF: present study is the first to report a lack of association
            between SNPs of USP40 and parkinson disease in Han Chinese
            patients. Other
REFERENCE   5  (bases 1 to 5695)
  AUTHORS   Kenny,E.E., Pe'er,I., Karban,A., Ozelius,L., Mitchell,A.A.,
            Ng,S.M., Erazo,M., Ostrer,H., Abraham,C., Abreu,M.T., Atzmon,G.,
            Barzilai,N., Brant,S.R., Bressman,S., Burns,E.R., Chowers,Y.,
            Clark,L.N., Darvasi,A., Doheny,D., Duerr,R.H., Eliakim,R.,
            Giladi,N., Gregersen,P.K., Hakonarson,H., Jones,M.R., Marder,K.,
            McGovern,D.P., Mulle,J., Orr-Urtreger,A., Proctor,D.D., Pulver,A.,
            Rotter,J.I., Silverberg,M.S., Ullman,T., Warren,S.T., Waterman,M.,
            Zhang,W., Bergman,A., Mayer,L., Katz,S., Desnick,R.J., Cho,J.H. and
            Peter,I.
  TITLE     A genome-wide scan of Ashkenazi Jewish Crohn's disease suggests
            novel susceptibility loci
  JOURNAL   PLoS Genet 8 (3), e1002559 (2012)
   PUBMED   22412388
REFERENCE   6  (bases 1 to 5695)
  AUTHORS   Li,Y., Schrodi,S., Rowland,C., Tacey,K., Catanese,J. and Grupe,A.
  TITLE     Genetic evidence for ubiquitin-specific proteases USP24 and USP40
            as candidate genes for late-onset Parkinson disease
  JOURNAL   Hum Mutat 27 (10), 1017-1023 (2006)
   PUBMED   16917932
  REMARK    GeneRIF: Da suggest that genetic variants in USP40 affect the risk
            for late-onset Parkinson disease (PD), which is consistent with the
            predicted role of the ubiquitination pathway in PD etiology.
            GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   7  (bases 1 to 5695)
  AUTHORS   Quesada,V., Diaz-Perales,A., Gutierrez-Fernandez,A., Garabaya,C.,
            Cal,S. and Lopez-Otin,C.
  TITLE     Cloning and enzymatic analysis of 22 novel human ubiquitin-specific
            proteases
  JOURNAL   Biochem Biophys Res Commun 314 (1), 54-62 (2004)
   PUBMED   14715245
REFERENCE   8  (bases 1 to 5695)
  AUTHORS   Puente,X.S., Sanchez,L.M., Overall,C.M. and Lopez-Otin,C.
  TITLE     Human and mouse proteases: a comparative genomic approach
  JOURNAL   Nat Rev Genet 4 (7), 544-558 (2003)
   PUBMED   12838346
  REMARK    Review article
REFERENCE   9  (bases 1 to 5695)
  AUTHORS   Bass,B.L.
  TITLE     RNA editing by adenosine deaminases that act on RNA
  JOURNAL   Annu Rev Biochem 71, 817-846 (2002)
   PUBMED   12045112
  REMARK    Review article
REFERENCE   10 (bases 1 to 5695)
  AUTHORS   Chen,X., Zhang,Y., Douglas,L. and Zhou,P.
  TITLE     UV-damaged DNA-binding proteins are targets of CUL-4A-mediated
            ubiquitination and degradation
  JOURNAL   J Biol Chem 276 (51), 48175-48182 (2001)
   PUBMED   11673459
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC019072.8 and AC019221.4.
            
            On Apr 29, 2020 this sequence version replaced NM_001365479.1.
            
            Summary: Modification of cellular proteins by ubiquitin is an
            essential regulatory mechanism controlled by the coordinated action
            of multiple ubiquitin-conjugating and deubiquitinating enzymes.
            USP40 belongs to a large family of cysteine proteases that function
            as deubiquitinating enzymes (Quesada et al., 2004 [PubMed
            14715245]).[supplied by OMIM, Mar 2008].
            
            Transcript Variant: This variant (1), as well as variant 3, encodes
            isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038196.2692259.1,
                                           SRR14038197.699721.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000678225.2/ ENSP00000502952.1
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-99                AC019072.8         109229-109327
            100-317             AC019072.8         110438-110655
            318-385             AC019072.8         113208-113275
            386-499             AC019072.8         116087-116200
            500-664             AC019072.8         118992-119156
            665-811             AC019072.8         121485-121631
            812-955             AC019072.8         124492-124635
            956-1084            AC019072.8         126782-126910
            1085-1180           AC019072.8         133648-133743
            1181-1288           AC019072.8         135242-135349
            1289-1589           AC019072.8         142232-142532
            1590-1671           AC019072.8         146499-146580
            1672-1843           AC019221.4         195-366
            1844-1928           AC019221.4         2211-2295
            1929-1999           AC019221.4         3211-3281
            2000-2319           AC019221.4         4284-4603
            2320-2443           AC019221.4         6659-6782
            2444-2501           AC019221.4         8102-8159
            2502-2555           AC019221.4         15151-15204
            2556-2644           AC019221.4         15976-16064
            2645-2731           AC019221.4         17638-17724
            2732-2768           AC019221.4         27858-27894
            2769-2833           AC019221.4         29161-29225
            2834-2908           AC019221.4         30941-31015
            2909-3035           AC019221.4         34222-34348
            3036-3130           AC019221.4         36512-36606
            3131-3249           AC019221.4         38290-38408
            3250-3315           AC019221.4         39469-39534
            3316-3526           AC019221.4         41796-42006
            3527-3622           AC019221.4         42147-42242
            3623-3717           AC019221.4         46476-46570
            3718-5695           AC019221.4         50270-52247
FEATURES             Location/Qualifiers
     source          1..5695
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2q37.1"
     gene            1..5695
                     /gene="USP40"
                     /note="ubiquitin specific peptidase 40"
                     /db_xref="GeneID:55230"
                     /db_xref="HGNC:HGNC:20069"
                     /db_xref="MIM:610570"
     exon            1..99
                     /gene="USP40"
                     /inference="alignment:Splign:2.1.0"
     exon            100..317
                     /gene="USP40"
                     /inference="alignment:Splign:2.1.0"
     CDS             119..3829
                     /gene="USP40"
                     /EC_number="3.4.19.12"
                     /note="isoform 1 is encoded by transcript variant 1;
                     ubiquitin specific protease 40; ubiquitin
                     carboxyl-terminal hydrolase 40;
                     ubiquitin-specific-processing protease 40;
                     deubiquitinating enzyme 40; ubiquitin thioesterase 40;
                     ubiquitin thiolesterase 40"
                     /codon_start=1
                     /product="ubiquitin carboxyl-terminal hydrolase 40 isoform
                     1"
                     /protein_id="NP_001352408.1"
                     /db_xref="CCDS:CCDS92972.1"
                     /db_xref="GeneID:55230"
                     /db_xref="HGNC:HGNC:20069"
                     /db_xref="MIM:610570"
                     /translation="MFGDLFEEEYSTVSNNQYGKGKKLKTKALEPPAPREFTNLSGIR
                     NQGGTCYLNSLLQTLHFTPEFREALFSLGPEELGLFEDKDKPDAKVRIIPLQLQRLFA
                     QLLLLDQEAASTADLTDSFGWTSNEEMRQHDVQELNRILFSALETSLVGTSGHDLIYR
                     LYHGTIVNQIVCKECKNVSERQEDFLDLTVAVKNVSGLEDALWNMYVEEEVFDCDNLY
                     HCGTCDRLVKAAKSAKLRKLPPFLTVSLLRFNFDFVKCERYKETSCYTFPLRINLKPF
                     CEQSELDDLEYIYDLFSVIIHKGGCYGGHYHVYIKDVDHLGNWQFQEEKSKPDVNLKD
                     LQSEEEIDHPLMILKAILLEEENNLIPVDQLGQKLLKKIGISWNKKYRKQHGPLRKFL
                     QLHSQIFLLSSDESTVRLLKNSSLQAESDFQRNDQQIFKMLPPESPGLNNSISCPHWF
                     DINDSKVQPIREKDIEQQFQGKESAYMLFYRKSQLQRPPEARANPRYGVPCHLLNEMD
                     AANIELQTKRAECDSANNTFELHLHLGPQYHFFNGALHPVVSQTESVWDLTFDKRKTL
                     GDLRQSIFQLLEFWEGDMVLSVAKLVPAGLHIYQSLGGDELTLCETEIADGEDIFVWN
                     GVEVGGVHIQTGIDCEPLLLNVLHLDTSSDGEKCCQVIESPHVFPANAEVGTVLTALA
                     IPAGVIFINSAGCPGGEGWTAIPKEDMRKTFREQGLRNGSSILIQDSHDDNSLLTKEE
                     KWVTSMNEIDWLHVKNLCQLESEEKQVKISATVNTMVFDIRIKAIKELKLMKELADNS
                     CLRPIDRNGKLLCPVPDSYTLKEAELKMGSSLGLCLGKAPSSSQLFLFFAMGSDVQPG
                     TEMEIVVEETISVRDCLKLMLKKSGLQGDAWHLRKMDWCYEAGEPLCEEDATLKELLI
                     CSGDTLLLIEGQLPPLGFLKVPIWWYQLQGPSGHWESHQDQTNCTSSWGRVWRATSSQ
                     GASGNEPAQVSLLYLGDIEISEDATLAELKSQAMTLPPFLEFGVPSPAHLRAWTVERK
                     RPGRLLRTDRQPLREYKLGRRIEICLEPLQKGENLGPQDVLLRTQVRIPGERTYAPAL
                     DLVWNAAQGGTAGSLRQRVADFYRLPVEKIEIAKYFPEKFEWLPISSWNQQITKRKKK
                     KKQDYLQGAPYYLKDGDTIGVKNLLIDDDDDFSTIRDDTGKEKQKQRALGRRKSQEAL
                     HEQSSYILSSAETPARPRAPETSLSIHVGSFR"
     exon            318..385
                     /gene="USP40"
                     /inference="alignment:Splign:2.1.0"
     exon            386..499
                     /gene="USP40"
                     /inference="alignment:Splign:2.1.0"
     exon            500..664
                     /gene="USP40"
                     /inference="alignment:Splign:2.1.0"
     exon            665..811
                     /gene="USP40"
                     /inference="alignment:Splign:2.1.0"
     exon            812..955
                     /gene="USP40"
                     /inference="alignment:Splign:2.1.0"
     exon            956..1084
                     /gene="USP40"
                     /inference="alignment:Splign:2.1.0"
     exon            1085..1180
                     /gene="USP40"
                     /inference="alignment:Splign:2.1.0"
     exon            1181..1288
                     /gene="USP40"
                     /inference="alignment:Splign:2.1.0"
     exon            1289..1589
                     /gene="USP40"
                     /inference="alignment:Splign:2.1.0"
     exon            1590..1671
                     /gene="USP40"
                     /inference="alignment:Splign:2.1.0"
     exon            1672..1843
                     /gene="USP40"
                     /inference="alignment:Splign:2.1.0"
     exon            1844..1928
                     /gene="USP40"
                     /inference="alignment:Splign:2.1.0"
     exon            1929..1999
                     /gene="USP40"
                     /inference="alignment:Splign:2.1.0"
     exon            2000..2319
                     /gene="USP40"
                     /inference="alignment:Splign:2.1.0"
     exon            2320..2443
                     /gene="USP40"
                     /inference="alignment:Splign:2.1.0"
     exon            2444..2501
                     /gene="USP40"
                     /inference="alignment:Splign:2.1.0"
     exon            2502..2555
                     /gene="USP40"
                     /inference="alignment:Splign:2.1.0"
     exon            2556..2644
                     /gene="USP40"
                     /inference="alignment:Splign:2.1.0"
     exon            2645..2731
                     /gene="USP40"
                     /inference="alignment:Splign:2.1.0"
     exon            2732..2768
                     /gene="USP40"
                     /inference="alignment:Splign:2.1.0"
     exon            2769..2833
                     /gene="USP40"
                     /inference="alignment:Splign:2.1.0"
     exon            2834..2908
                     /gene="USP40"
                     /inference="alignment:Splign:2.1.0"
     exon            2909..3035
                     /gene="USP40"
                     /inference="alignment:Splign:2.1.0"
     exon            3036..3130
                     /gene="USP40"
                     /inference="alignment:Splign:2.1.0"
     exon            3131..3249
                     /gene="USP40"
                     /inference="alignment:Splign:2.1.0"
     exon            3250..3315
                     /gene="USP40"
                     /inference="alignment:Splign:2.1.0"
     exon            3316..3526
                     /gene="USP40"
                     /inference="alignment:Splign:2.1.0"
     exon            3527..3622
                     /gene="USP40"
                     /inference="alignment:Splign:2.1.0"
     exon            3623..3717
                     /gene="USP40"
                     /inference="alignment:Splign:2.1.0"
     exon            3718..5695
                     /gene="USP40"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5672..5677
                     /regulatory_class="polyA_signal_sequence"
                     /gene="USP40"
                     /note="hexamer: AATAAA"
     polyA_site      5695
                     /gene="USP40"
                     /note="major polyA site"
ORIGIN      
        1 actttctgga gacccgccct cgccaacatg gcggcgccca gttggggcgg gttcgttcgc
       61 ttcgcgtttt ggccagggcg ggggtctggg ctttaggcag gtagtattta gtttcacaat
      121 gtttggggac ctgtttgaag aggagtattc cactgtgtct aataatcagt atggaaaagg
      181 gaagaaatta aagactaaag ctttggagcc acctgctcct agagaattca ccaatttaag
      241 cggaatcaga aatcagggtg gaacctgtta cctcaattcc cttcttcaga ctcttcattt
      301 cacacctgaa ttcagagaag ctctattttc tcttggccca gaagagcttg gtttgtttga
      361 agataaggat aaacccgatg caaaggttcg aatcatccct ttacagttac agcgcttgtt
      421 tgctcagctt ctgctcttag accaggaagc tgcatccaca gcagacctca ctgacagctt
      481 tgggtggacc agtaatgagg aaatgaggca acatgatgtg caggaactga atcgaatcct
      541 cttcagcgct ttggaaactt ctttagttgg gacctccggt catgacctca tctatcgtct
      601 gtaccatgga accattgtta accagattgt ttgtaaagaa tgtaagaacg ttagcgagag
      661 gcaggaagac ttcttagatc taacagtagc agtcaaaaat gtatccggtt tggaagatgc
      721 tctctggaac atgtatgtag aagaggaagt ttttgattgt gacaacttgt accactgtgg
      781 aacttgtgac aggctggtta aagcagcaaa gtcggccaaa ttacgtaagc tgcctccttt
      841 tcttactgtt tcattactaa gatttaattt tgattttgtg aaatgcgaac gctacaagga
      901 aactagctgt tatacattcc ctctccggat taatctcaag cccttttgtg aacagagtga
      961 attggatgac ttagaatata tatatgacct cttctcagtt attatacaca aaggtggctg
     1021 ctacggaggc cattaccatg tatatattaa agatgttgat catttgggaa actggcagtt
     1081 tcaagaggaa aaaagtaaac cagatgtgaa tctgaaagat ctccagagtg aagaagagat
     1141 tgatcatcca ctgatgattc taaaagcaat cttattagag gaggagaata atctaattcc
     1201 tgttgatcag ctgggccaga aacttttgaa aaagatagga atatcttgga acaagaagta
     1261 cagaaaacag catggaccac tgcggaagtt cttacagctc cattctcaga tatttctact
     1321 cagttcagat gaaagtacag ttcgtctctt gaagaatagt tctctccagg ctgagtctga
     1381 tttccaaagg aatgaccagc aaattttcaa gatgcttcct ccagaatccc caggtttaaa
     1441 caatagcatc tcctgtcccc actggtttga tataaatgat tctaaagtcc agccaatcag
     1501 ggaaaaggat attgaacagc aatttcaggg taaagaaagt gcctacatgt tgttttatcg
     1561 gaaatcccag ttgcagagac cccctgaagc tcgagctaat ccaagatatg gggttccatg
     1621 tcatttactg aatgaaatgg atgcagctaa cattgaactg caaaccaaaa gggcagaatg
     1681 tgattctgca aacaatactt ttgaattgca tcttcacctg ggccctcagt atcatttctt
     1741 caatggggct ctgcacccag tagtctctca aacagaaagc gtgtgggatt tgacctttga
     1801 taaaagaaaa actttaggag atctccggca gtcaatattt cagctgttag aattttggga
     1861 aggagacatg gttcttagtg ttgcaaagct tgtaccagca ggacttcaca tttaccagtc
     1921 acttggcggg gatgaactga cactgtgtga aactgaaatt gctgatgggg aagacatctt
     1981 tgtgtggaat ggggtggagg ttggtggagt ccacattcaa actggtattg actgcgaacc
     2041 tctactttta aatgttcttc atctagacac aagcagtgat ggagaaaagt gttgtcaggt
     2101 gatagaatct ccacatgtct ttccagctaa tgcagaagtg ggcactgtcc tcacagcctt
     2161 agcaatccca gcaggtgtca tcttcatcaa cagtgctgga tgtccaggtg gggagggttg
     2221 gacggccatc cccaaggaag acatgaggaa gacgttcagg gagcaagggc tcagaaatgg
     2281 aagctcaatt ttaattcagg attctcatga tgataacagc ttgttgacca aggaagagaa
     2341 atgggtcact agtatgaatg agattgactg gctccacgtt aaaaatttat gccagttaga
     2401 atctgaagag aagcaagtta aaatatcagc aactgttaac acaatggtgt ttgatattcg
     2461 aattaaagcc ataaaggaat taaaattaat gaaggaacta gctgacaaca gctgtttgag
     2521 acctattgat agaaatggga agcttctttg tccagtgccg gacagctata ctttgaagga
     2581 agcagaattg aagatgggaa gttcattggg actgtgtctt ggaaaagcac caagttcgtc
     2641 tcagttgttc ctgttttttg caatggggag tgacgttcaa cctgggacag aaatggaaat
     2701 cgtagtagaa gaaacaatat ctgtgagaga ttgtttaaag ttaatgctga agaaatctgg
     2761 cctacaagga gatgcctggc atttacgaaa aatggattgg tgctatgaag ctggagagcc
     2821 tttatgtgaa gaagatgcaa cactgaaaga acttctgata tgttctggag atactttgct
     2881 tttaattgaa ggacaacttc ctcctctggg tttcctgaag gtgcccatct ggtggtacca
     2941 gcttcagggt ccctcaggac actgggagag tcatcaggac cagaccaact gtacttcgtc
     3001 ttggggcaga gtttggagag ccacttccag ccaaggtgct tctgggaacg agcctgcgca
     3061 agtttctctc ctctacttgg gagacataga gatctcagaa gatgccacgc tggcggagct
     3121 gaagtctcag gccatgacct tgcctccttt cctggagttc ggtgtcccgt ccccagccca
     3181 cctcagagcc tggacggtgg agaggaagcg cccaggcagg cttttacgaa ctgaccggca
     3241 gccactcagg gaatataaac taggacggag aattgagatc tgcttagagc cccttcagaa
     3301 aggcgaaaac ttgggccccc aggacgtgct gctgaggaca caggtgcgca tccctggtga
     3361 gaggacctat gcccctgccc tggacctggt gtggaacgcg gcccagggtg ggactgccgg
     3421 ctccctgagg cagagagttg ccgatttcta tcgtcttccc gtggagaaga ttgaaattgc
     3481 caaatacttt cccgaaaagt tcgagtggct tccgatatct agctggaacc aacaaataac
     3541 caagaggaaa aagaaaaaaa aacaagatta tttgcaaggg gcaccgtatt acttgaaaga
     3601 cggagatact attggtgtta agaatctcct gattgacgac gatgatgatt tcagtacaat
     3661 cagagatgac actggaaaag aaaagcagaa acaacgggcc ctggggagaa ggaaaagcca
     3721 agaagccctc catgagcaga gcagctacat cctctccagt gcagagacgc ctgcccggcc
     3781 ccgagccccg gaaacttctc tctccatcca cgtggggagc ttcagataac cgcgccgctg
     3841 cacggctcta ctcccgatga actctccggc tgatgccaca aacgtgggtt tcctgggcat
     3901 ggggactggc tgcctggcgc ctccaatccc aaatcctctg cttcctttga gcacagggac
     3961 ggctcctctg aggcctggcc agtgcatgta gtcacttagc tctgcaacac gtggcagcca
     4021 cgggggctgg tgcagctctg gatgtcgccc acccagctgc cagtaggtgc tgggctctct
     4081 cacacagcac ccggccccag ctgccttttt ttttctttta accagaaaat gcacaacgtg
     4141 tgcgtgaacc gcaggtatgg aggcagcggc atgccgttgc tccgctgtgg gaggtgtgtg
     4201 gggtcaggcc agccactttc ctccgtgttc agatgactct cgttcgccct gaccggcttc
     4261 tcacagtgtc tcaggccact gcgccaccgc gctggtgctg agcagaagcg ggcagaagtg
     4321 gggtctgctt tcaggacttc atttccccca ctcgttccgg ccccgcatgc tccacgtctg
     4381 ccctttggtc tgagttaaaa ctgcgatgct gaaaagtgcg agctctttcc acgaggagga
     4441 gccacacagg gtggcctccg agggtgagtc gctctgctaa gcaagggcag ccgctgcacg
     4501 tcagcccgca ggccaagggt ccagcttatc ctgggtgctc tgtgatcaga aggtccttgg
     4561 atcccgagga ctgcagctgc tgccgtccac agcgcctcag cctctcttcc tgtgtggaag
     4621 cggggcaggc agggctgtgg cagacaggcc tggcatagcc caggttccag gtgtcctggg
     4681 cagcctgacc ggtttcctga gtagcctcaa tgaaaacacc tgagaaaaag aaaatgtaaa
     4741 ctaaggaagg gttttcccac ttaatccaac ccagatttct attcaactta aaggatttaa
     4801 ttggcatttg tgagaaataa tagtacctgt gtcactgagt tgattgattt gggacataga
     4861 cggttgactt tcccagacag cagcttagcg gaaagcagca tcccgaagac ggtgtcgcat
     4921 gtcctgagcc tgcttgtcac ctgggcctca cggtttctcg tcagccccgt cactgatggg
     4981 aagcagcact gaagtgtgag ggcagaaagg acaccgctgg agtcaggcgc tcccctgcct
     5041 gtgacccttt tccaacaagc tgatgctgag ccagcggcct gctttgtccc tcatactcct
     5101 cccaacagtc caaaccccta ccagacagaa gccacgtcgc ttctgcacac gtgtctgaga
     5161 gcgtctgcca tagacgtctg tgcgtttccg tgaagcactg cgccctaagg acccaactct
     5221 gactagcagc tgcctcccac tcccaaacac taaccccgct caggagactc gcactgggtg
     5281 tagactgcgt ctttgcagag ggagatgata gaggcttctg atgacgccag agctgtaagt
     5341 gtcgtgacga gctgggcgcc cagcccttct taagctgttc tgtttctgtg gctttaactg
     5401 acatatttct gtagcatctg ccttcatctc atctcagcgt aatgaaatat taatgaaatc
     5461 gctgaaaagc tttgccttcg agaggccaga agcctcgcgg aatgtctgca agtccaaaga
     5521 cgcgtgtggg ttgtgccctg aagtgccgtc cagcaggcgc gtgcggccgg gccggcctgt
     5581 gcgtgtggcc tttgccttct tccctttctt cctgttttct gtttttttaa tttggggatt
     5641 gagaaagctg tacgattttg ttaaagaaaa aaataaacca ttttttaaag ttgta
//
