LOCUS       NM_032557               7081 bp    mRNA    linear   PRI 23-APR-2024
DEFINITION  Homo sapiens ubiquitin specific peptidase 38 (USP38), transcript
            variant 1, mRNA.
ACCESSION   NM_032557
VERSION     NM_032557.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 7081)
  AUTHORS   Zhang,T., Su,F., Wang,B., Liu,L., Lu,Y., Su,H., Ling,R., Yue,P.,
            Dai,H., Yang,T., Yang,J., Chen,R., Wu,R., Zhu,K., Zhao,D. and
            Hou,X.
  TITLE     Ubiquitin specific peptidase 38 epigenetically regulates KLF
            transcription factor 5 to augment malignant progression of lung
            adenocarcinoma
  JOURNAL   Oncogene 43 (16), 1190-1202 (2024)
   PUBMED   38409551
  REMARK    GeneRIF: Ubiquitin specific peptidase 38 epigenetically regulates
            KLF transcription factor 5 to augment malignant progression of lung
            adenocarcinoma.
REFERENCE   2  (bases 1 to 7081)
  AUTHORS   Wang,R., Cai,X., Li,X., Li,J., Liu,X., Wang,J. and Xiao,W.
  TITLE     USP38 promotes deubiquitination of K11-linked polyubiquitination of
            HIF1alpha at Lys769 to enhance hypoxia signaling
  JOURNAL   J Biol Chem 300 (1), 105532 (2024)
   PUBMED   38072059
  REMARK    GeneRIF: USP38 promotes deubiquitination of K11-linked
            polyubiquitination of HIF1alpha at Lys769 to enhance hypoxia
            signaling.
REFERENCE   3  (bases 1 to 7081)
  AUTHORS   Gong,Y., Kong,B., Shuai,W., Chen,T., Zhang,J.J. and Huang,H.
  TITLE     USP38 regulates inflammatory cardiac remodeling after myocardial
            infarction
  JOURNAL   Clin Sci (Lond) 137 (21), 1665-1681 (2023)
   PUBMED   37903290
  REMARK    GeneRIF: USP38 regulates inflammatory cardiac remodeling after
            myocardial infarction.
REFERENCE   4  (bases 1 to 7081)
  AUTHORS   Wang,J., Gu,Y., Yan,X., Zhang,J., Wang,J. and Ding,Y.
  TITLE     USP38 inhibits colorectal cancer cell proliferation and migration
            via downregulating HMX3 ubiquitylation
  JOURNAL   Cell Cycle 22 (10), 1169-1181 (2023)
   PUBMED   36204976
  REMARK    GeneRIF: USP38 inhibits colorectal cancer cell proliferation and
            migration via downregulating HMX3 ubiquitylation.
REFERENCE   5  (bases 1 to 7081)
  AUTHORS   Yi,X.M., Li,M., Chen,Y.D., Shu,H.B. and Li,S.
  TITLE     Reciprocal regulation of IL-33 receptor-mediated inflammatory
            response and pulmonary fibrosis by TRAF6 and USP38
  JOURNAL   Proc Natl Acad Sci U S A 119 (10), e2116279119 (2022)
   PUBMED   35238669
  REMARK    GeneRIF: Reciprocal regulation of IL-33 receptor-mediated
            inflammatory response and pulmonary fibrosis by TRAF6 and USP38.
REFERENCE   6  (bases 1 to 7081)
  AUTHORS   Tsai,I.C., Adams,K.A., Tzeng,J.A., Shennib,O., Tan,P.L. and
            Katsanis,N.
  TITLE     Genome-wide suppressor screen identifies USP35/USP38 as therapeutic
            candidates for ciliopathies
  JOURNAL   JCI Insight 4 (22), 130516 (2019)
   PUBMED   31723061
  REMARK    GeneRIF: Genome-wide suppressor screen identifies USP35/USP38 as
            therapeutic candidates for ciliopathies.
            Publication Status: Online-Only
REFERENCE   7  (bases 1 to 7081)
  AUTHORS   Lin,M., Zhao,Z., Yang,Z., Meng,Q., Tan,P., Xie,W., Qin,Y.,
            Wang,R.F. and Cui,J.
  TITLE     USP38 Inhibits Type I Interferon Signaling by Editing TBK1
            Ubiquitination through NLRP4 Signalosome
  JOURNAL   Mol Cell 64 (2), 267-281 (2016)
   PUBMED   27692986
REFERENCE   8  (bases 1 to 7081)
  AUTHORS   Quesada,V., Diaz-Perales,A., Gutierrez-Fernandez,A., Garabaya,C.,
            Cal,S. and Lopez-Otin,C.
  TITLE     Cloning and enzymatic analysis of 22 novel human ubiquitin-specific
            proteases
  JOURNAL   Biochem Biophys Res Commun 314 (1), 54-62 (2004)
   PUBMED   14715245
REFERENCE   9  (bases 1 to 7081)
  AUTHORS   Puente,X.S., Sanchez,L.M., Overall,C.M. and Lopez-Otin,C.
  TITLE     Human and mouse proteases: a comparative genomic approach
  JOURNAL   Nat Rev Genet 4 (7), 544-558 (2003)
   PUBMED   12838346
  REMARK    Review article
REFERENCE   10 (bases 1 to 7081)
  AUTHORS   Hu,R.M., Han,Z.G., Song,H.D., Peng,Y.D., Huang,Q.H., Ren,S.X.,
            Gu,Y.J., Huang,C.H., Li,Y.B., Jiang,C.L., Fu,G., Zhang,Q.H.,
            Gu,B.W., Dai,M., Mao,Y.F., Gao,G.F., Rong,R., Ye,M., Zhou,J.,
            Xu,S.H., Gu,J., Shi,J.X., Jin,W.R., Zhang,C.K., Wu,T.M.,
            Huang,G.Y., Chen,Z., Chen,M.D. and Chen,J.L.
  TITLE     Gene expression profiling in the human
            hypothalamus-pituitary-adrenal axis and full-length cDNA cloning
  JOURNAL   Proc Natl Acad Sci U S A 97 (17), 9543-9548 (2000)
   PUBMED   10931946
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC039115.1, BG575871.1, AK091712.1 and AC099549.5.
            
            On Mar 12, 2014 this sequence version replaced NM_032557.5.
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660803.55518.1,
                                           SRR1660807.210210.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000307017.9/ ENSP00000303434.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3122              BC039115.1         1-3122
            3123-3589           BG575871.1         232-698
            3590-4693           AK091712.1         1364-2467
            4694-7081           AC099549.5         22853-25240
FEATURES             Location/Qualifiers
     source          1..7081
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4q31.21"
     gene            1..7081
                     /gene="USP38"
                     /gene_synonym="HP43.8KD"
                     /note="ubiquitin specific peptidase 38"
                     /db_xref="GeneID:84640"
                     /db_xref="HGNC:HGNC:20067"
                     /db_xref="MIM:618322"
     exon            1..1216
                     /gene="USP38"
                     /gene_synonym="HP43.8KD"
                     /inference="alignment:Splign:2.1.0"
     CDS             535..3663
                     /gene="USP38"
                     /gene_synonym="HP43.8KD"
                     /EC_number="3.4.19.12"
                     /note="isoform 1 is encoded by transcript variant 1;
                     ubiquitin specific protease 38; ubiquitin
                     carboxyl-terminal hydrolase 38; ubiquitin thioesterase 38;
                     deubiquitinating enzyme 38; ubiquitin-specific-processing
                     protease 38; ubiquitin thiolesterase 38"
                     /codon_start=1
                     /product="ubiquitin carboxyl-terminal hydrolase 38 isoform
                     1"
                     /protein_id="NP_115946.2"
                     /db_xref="CCDS:CCDS3758.1"
                     /db_xref="GeneID:84640"
                     /db_xref="HGNC:HGNC:20067"
                     /db_xref="MIM:618322"
                     /translation="MDKILEGLVSSSHPLPLKRVIVRKVVESAEHWLDEAQCEAMFDL
                     TTRLILEGQDPFQRQVGHQVLEAYARYHRPEFESFFNKTFVLGLLHQGYHSLDRKDVA
                     ILDYIHNGLKLIMSCPSVLDLFSLLQVEVLRMVCERPEPQLCARLSDLLTDFVQCIPK
                     GKLSITFCQQLVRTIGHFQCVSTQERELREYVSQVTKVSNLLQNIWKAEPATLLPSLQ
                     EVFASISSTDASFEPSVALASLVQHIPLQMITVLIRSLTTDPNVKDASMTQALCRMID
                     WLSWPLAQHVDTWVIALLKGLAAVQKFTILIDVTLLKIELVFNRLWFPLVRPGALAVL
                     SHMLLSFQHSPEAFHLIVPHVVNLVHSFKNDGLPSSTAFLVQLTELIHCMMYHYSGFP
                     DLYEPILEAIKDFPKPSEEKIKLILNQSAWTSQSNSLASCLSRLSGKSETGKTGLINL
                     GNTCYMNSVIQALFMATDFRRQVLSLNLNGCNSLMKKLQHLFAFLAHTQREAYAPRIF
                     FEASRPPWFTPRSQQDCSEYLRFLLDRLHEEEKILKVQASHKPSEILECSETSLQEVA
                     SKAAVLTETPRTSDGEKTLIEKMFGGKLRTHIRCLNCRSTSQKVEAFTDLSLAFCPSS
                     SLENMSVQDPASSPSIQDGGLMQASVPGPSEEPVVYNPTTAAFICDSLVNEKTIGSPP
                     NEFYCSENTSVPNESNKILVNKDVPQKPGGETTPSVTDLLNYFLAPEILTGDNQYYCE
                     NCASLQNAEKTMQITEEPEYLILTLLRFSYDQKYHVRRKILDNVSLPLVLELPVKRIT
                     SFSSLSESWSVDVDFTDLSENLAKKLKPSGTDEASCTKLVPYLLSSVVVHSGISSESG
                     HYYSYARNITSTDSSYQMYHQSEALALASSQSHLLGRDSPSAVFEQDLENKEMSKEWF
                     LFNDSRVTFTSFQSVQKITSRFPKDTAYVLLYKKQHSTNGLSGNNPTSGLWINGDPPL
                     QKELMDAITKDNKLYLQEQELNARARALQAASASCSFRPNGFDDNDPPGSCGPTGGGG
                     GGGFNTVGRLVF"
     exon            1217..1352
                     /gene="USP38"
                     /gene_synonym="HP43.8KD"
                     /inference="alignment:Splign:2.1.0"
     exon            1353..1482
                     /gene="USP38"
                     /gene_synonym="HP43.8KD"
                     /inference="alignment:Splign:2.1.0"
     exon            1483..1584
                     /gene="USP38"
                     /gene_synonym="HP43.8KD"
                     /inference="alignment:Splign:2.1.0"
     exon            1585..1743
                     /gene="USP38"
                     /gene_synonym="HP43.8KD"
                     /inference="alignment:Splign:2.1.0"
     exon            1744..1937
                     /gene="USP38"
                     /gene_synonym="HP43.8KD"
                     /inference="alignment:Splign:2.1.0"
     exon            1938..2031
                     /gene="USP38"
                     /gene_synonym="HP43.8KD"
                     /inference="alignment:Splign:2.1.0"
     exon            2032..2138
                     /gene="USP38"
                     /gene_synonym="HP43.8KD"
                     /inference="alignment:Splign:2.1.0"
     exon            2139..3501
                     /gene="USP38"
                     /gene_synonym="HP43.8KD"
                     /inference="alignment:Splign:2.1.0"
     exon            3502..7081
                     /gene="USP38"
                     /gene_synonym="HP43.8KD"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4550..4555
                     /regulatory_class="polyA_signal_sequence"
                     /gene="USP38"
                     /gene_synonym="HP43.8KD"
                     /note="hexamer: AGTAAA"
     polyA_site      4575
                     /gene="USP38"
                     /gene_synonym="HP43.8KD"
                     /note="major polyA site"
     regulatory      4676..4681
                     /regulatory_class="polyA_signal_sequence"
                     /gene="USP38"
                     /gene_synonym="HP43.8KD"
                     /note="hexamer: ATTAAA"
     polyA_site      4708
                     /gene="USP38"
                     /gene_synonym="HP43.8KD"
                     /note="major polyA site"
     regulatory      4778..4783
                     /regulatory_class="polyA_signal_sequence"
                     /gene="USP38"
                     /gene_synonym="HP43.8KD"
                     /note="hexamer: GATAAA"
     polyA_site      4799
                     /gene="USP38"
                     /gene_synonym="HP43.8KD"
     regulatory      6951..6956
                     /regulatory_class="polyA_signal_sequence"
                     /gene="USP38"
                     /gene_synonym="HP43.8KD"
                     /note="hexamer: TATAAA"
     polyA_site      6973
                     /gene="USP38"
                     /gene_synonym="HP43.8KD"
                     /note="major polyA site"
     regulatory      7016..7021
                     /regulatory_class="polyA_signal_sequence"
                     /gene="USP38"
                     /gene_synonym="HP43.8KD"
                     /note="hexamer: CATAAA"
     polyA_site      7037
                     /gene="USP38"
                     /gene_synonym="HP43.8KD"
ORIGIN      
        1 acttcaaaat ccgggtcaaa gggtgtcgct tcggtctctt ctccccggct gatcccagca
       61 ctctccgtga cagcgcctcc tgactcagcc caggaccggc ttcttctcac gacctgctgg
      121 agactggacg cccacacctg acccggaact cggaggcgtg cttcctccac ccgccggcta
      181 gcagccccgg gccctgagct cccgccgacg ccgctggggg gcccgacagg cccctcggcg
      241 ctgatgctga gtgggatcga gggcccgggg cggcggcgga gtacgggcct ctggcgcctt
      301 aggccagccg caggtgtcgg ttcttaggct ctccaggctc gctagctccc gccccggctt
      361 ggatgggtct ccctgcgcca taaatgtggc tgctgaggcg gcggtggccg tggcccgtcg
      421 cgctgctgct gcggcgctcc aagttcatct ccgccccggg gctctcctgc cccacctcgg
      481 ggctgccgcc acccgctcct tatcccctgg ccctggcctt gcagcgtggc gacaatggac
      541 aagatcctgg agggccttgt gagttcctcg catcccctgc ccctcaagcg ggtgattgtg
      601 cggaaggtgg tggaatcggc ggagcactgg ctagacgagg cgcagtgcga ggccatgttt
      661 gacctgacga cccggctcat cctggagggc caggaccctt tccagcggca ggtggggcac
      721 caggtgctgg aggcctacgc acgataccac cggccagagt tcgagtcctt cttcaacaag
      781 accttcgtgt tgggcctcct tcatcagggc taccactctc tggacaggaa ggatgtagcc
      841 atcctggact acattcacaa cggcctgaag ctgattatga gctgtccgtc ggtgctggat
      901 ctctttagcc tcctgcaggt agaggtgtta cggatggtgt gtgagaggcc ggagccgcag
      961 ctctgtgccc gactgagcga ccttctgacc gactttgtgc aatgcatccc caaggggaaa
     1021 ttgtccatca cgttctgtca acagctggtt cgaacgatag gccatttcca gtgcgtgtcc
     1081 acccaggaaa gagagctgcg ggaatatgtc tcccaggtga caaaagtgag taacttgctg
     1141 cagaacatct ggaaggccga gcctgccaca ctactgcctt ccctgcaaga agtttttgca
     1201 agcatctctt ccacagatgc atcatttgaa ccttctgtag cattggcaag ccttgtgcag
     1261 catattcctc ttcagatgat tacagttctc atcaggagcc ttactacgga tccaaatgta
     1321 aaagatgcaa gtatgaccca agccctttgc agaatgattg actggctatc ctggccattg
     1381 gctcagcatg tggatacatg ggtaattgca ctcctgaaag gactggcagc tgtccagaag
     1441 tttactattt tgatagatgt tactttgctg aaaatagaac tggtttttaa tcgactttgg
     1501 tttcctcttg tgagacctgg tgctcttgca gttctttctc acatgctgct tagctttcag
     1561 cattctccag aggcgttcca tttgattgtt cctcatgtgg ttaatttggt tcattctttc
     1621 aaaaatgatg gtctgccttc aagtacagcc ttcttagtac aattaacaga attgatacac
     1681 tgtatgatgt atcattattc tggatttcca gatctctatg aacctattct ggaggcaata
     1741 aaggattttc ctaagcccag tgaagagaag attaagttaa ttctcaatca aagtgcctgg
     1801 acttctcaat ccaattcttt ggcgtcttgc ttgtctagac tttctggaaa atctgaaact
     1861 gggaaaactg gtcttattaa cctaggaaat acatgttata tgaacagtgt tatacaagcc
     1921 ttgtttatgg ccacagattt caggagacaa gtattatctt taaatctaaa tgggtgcaat
     1981 tcattaatga aaaaattaca gcatcttttt gcctttctgg cccatacaca gagggaagca
     2041 tacgcacctc ggatattctt tgaggcttcc agacctccat ggtttactcc cagatcacag
     2101 caagactgtt ctgaatacct cagatttctc cttgacaggc tccatgaaga agaaaagatc
     2161 ttgaaagttc aggcctcaca caagccttct gaaattctgg aatgcagtga aacttcttta
     2221 caggaagtag ctagtaaagc agcagtacta acagagaccc ctcgtacaag tgacggtgag
     2281 aagactttaa tagaaaaaat gtttggagga aaactacgaa ctcacatacg ttgtttgaac
     2341 tgcaggagta cctcacaaaa agtggaagcc tttacagatc tttcgcttgc cttttgtcct
     2401 tcctcttctt tggaaaacat gtctgtccaa gatccagcat catcacccag tatacaagat
     2461 ggtggtctaa tgcaagcctc tgtacccggt ccttcagaag aaccagtagt ttataatcca
     2521 acaacagctg ccttcatctg tgactcactt gtgaatgaaa aaaccatagg cagtcctcct
     2581 aatgagtttt actgttctga aaacacttct gtccctaacg aatctaacaa gattcttgtt
     2641 aataaagatg tacctcagaa accaggaggt gaaaccacac cttcagtaac tgacttacta
     2701 aattattttt tggctccaga gattcttact ggtgataacc aatattattg tgaaaactgt
     2761 gcctctctgc aaaatgctga gaaaactatg caaatcacgg aggaacctga ataccttatt
     2821 cttactctcc tgagattttc atatgatcag aagtatcatg tgagaaggaa aattttagac
     2881 aatgtatcac tgccactggt tttggagttg ccagttaaaa gaattacttc tttctcttca
     2941 ttgtcagaaa gttggtctgt agatgttgac ttcactgatc ttagtgagaa ccttgctaaa
     3001 aaattaaagc cttcagggac tgatgaagct tcctgcacaa aattggtgcc ctatctatta
     3061 agttccgttg tggttcactc tggtatatcc tctgaaagtg ggcattacta ttcttatgcc
     3121 aggaatatca caagtacaga ctcttcatat cagatgtacc accagtctga ggctctggca
     3181 ttagcatcct cccagagtca tttactaggg agagatagtc ccagtgcagt ttttgaacag
     3241 gatttggaaa ataaggaaat gtcaaaagaa tggtttttat ttaatgacag tagagtgaca
     3301 tttacttcat ttcagtcagt ccagaaaatt acgagcaggt ttccaaagga cacagcttat
     3361 gtgcttttgt ataaaaaaca gcatagtact aatggtttaa gtggtaataa cccaaccagt
     3421 ggactctgga taaatggaga cccacctcta cagaaagaac ttatggatgc tataacaaaa
     3481 gacaataaac tatatttaca ggaacaagag ttgaatgctc gagcccgggc cctccaagct
     3541 gcatctgctt catgttcatt tcggcccaat ggatttgatg acaacgaccc accaggaagc
     3601 tgtggaccaa ctggtggagg gggtggagga ggatttaata cagttggcag actcgtattt
     3661 tgatcctgag agagtccaaa atgcactggt cacgaaacgt ctaatactat gactgttaaa
     3721 atgtcagact ataacaaata tctatctttt atttttcatt agacccttat acttcaagag
     3781 aacacactca gtgcttgttt ttattttctt gacacattta ttaacaaaat gcatcatgga
     3841 aaaaaaaatc tacctcttaa aattccattt gcttttatgg ttagacatgc ttgaccaaaa
     3901 atgttcagaa gaaaatatgt acctggtccc taattaagct gcgttaaatt tggtagaagc
     3961 atttaaatgg tctatcttca gttttactga acaaaaaatg taatttattt agcattcttt
     4021 ataaaagaat tgatgctaga ggtaaaaaaa aatacttgtt tttaaaaaat cctttacgtc
     4081 ttgtgtaatt accccattat taaattcaag tccttgaaaa tcaactagag attataaagt
     4141 ctctaaagaa ggcaataaca aaatttatca agatatagta cttttcagtt tttgtttagt
     4201 gtcttcagca tcactgtgtc tgtatttcaa gtacaaatgt ttttaaaaag gattctttat
     4261 acatatgtgc tgaattgatt ttaagaaagt tgcatgatcc tgtaggagca acatttttac
     4321 ctaaaaaatg ctaactttat agtatttcta attgttcaag gattttaaaa ttctatttca
     4381 gggagtatat cttctgtggt tttgaaggag gtgagttctg tatgtgcctt gcagtactgt
     4441 aattcaaaaa taggaatctt tggctgcaaa attttaatga aatgttagga agtaattttc
     4501 gtgctaacat taaaattata actttttgaa aggtaataga ttttccagaa gtaaaatctg
     4561 atggttctaa atcaatcaat gtgatagttc atttttaact cttagaagaa ttcagaggaa
     4621 attaacccag ctaagtaaaa aatctgtctt gattttgtta cttattcctc agaatattaa
     4681 acattgatca catattttta gagttttaca tttgggtttt ttgtttgttt gtttcagtca
     4741 tatgtttggc actgttgttt ctattttcgt agttttagat aaaatgttaa aatgccaaac
     4801 cctaccttcc tacacttttt cttttgccag gaaactggaa acatgtcagt tctcctggtt
     4861 cttgattata cagtactcaa gagttatccc agttatcccc cttcctaaag gttttaactt
     4921 atccacagtt gtgcattgtt ctgaagattg gtctcatatt tattttgaaa acactttaag
     4981 gaaacaatgt tcttcgatga tttggggttt atctttttcc caagctttta tgacagtggt
     5041 taaaaaacag aaatcctcat gtttattcca ttacctccca ttcctaacct gtttccaatc
     5101 accaggaaga ttaggaaggc agattagatt aaaaactgaa aattctttgc agatttaatg
     5161 aaggttctcc tccttataaa tgaatgaacc agttatcatg cttttctgtg gttttcctat
     5221 cccaatagtg aatttctgag ctatcctgtg tgttcagtta tccacttact tgatagcaac
     5281 ttacgaccag attatatcag tcttggcatt tattgaaatt ggtaaagtga tttaatactt
     5341 gatagattga tattgggcta agatgcttct aggaactttc ataaaagcaa ttatacttgt
     5401 gcagctttat ctatgaatat caggtctctc aaggatttta tgtatcaaga taatatgtat
     5461 tgactttttt aaatgataaa atgaattcta gttagagtct ttccttggta tctgcagtgg
     5521 attggttcca gaacaccatc ccccaatatt aaaatccaca gatactcaag tcccttattt
     5581 atataaaata gcacagtatt tgcatataac ctgtgcacat cctcccatat actttaatct
     5641 ccagatgatt agatatgatt gcatagcact tacgttgtgc tatgtagttg ttatattgtt
     5701 ttttcatttg tactattttt tatgatattt attggttttt taaattttct atccaaagtt
     5761 gtttgaatct aaggatacag agcctgagga tatggaaagc tgactaaata tagtaacact
     5821 gaagagtatt caaatgataa ctcataccag taccaaaaac ttgaagactt ccttttaaca
     5881 ttaaaaatac agtaactttt tacgtgattt gttgaattca acatatttgg aaccagaata
     5941 atcagaaact tcattcaaaa cctatgcatc tgaacttttt tagtaaggta atactcagga
     6001 ctgttctgat tctaacagat ccctgttaat tacagattta tttgtcatat taggtctttt
     6061 ctttctccca tattcctaac ccgtgtacta gctccaactg ttgtgaggtt tgactctgaa
     6121 gactgagtag agtactattg ttgtttttct ttccttagtc agagtaatca gtttaaatga
     6181 agttgctcat tgctgctaag aagcattagg cttcactgct agcaaaaatg aaaaactaca
     6241 aatctgagtc tttctttcaa agatgtttat tgacataatt aaagtaaaaa attgtttaga
     6301 gatatgcaaa gaaggaaata tatatgatgt cacacaagct ccagtaagct atccactaag
     6361 caggtgcctg tgcaactctg atttatggca ttaacatatc aaattgaagg aaggattcta
     6421 gctcattttc cattcaagca tcttcccact gcctctcttc cagctaaata atcagagaag
     6481 cagggcagta tatccctgga gatccctgac ttttatctcc ataccttaaa ttgttggtag
     6541 atcctttgga tgtagagata aaaattcatt atgatgctag aggcattggg gggtccatgc
     6601 gaaaggttca aacagcctat tacattaatg cacatgtgga aagaacaaaa attttcaagc
     6661 taagtcttaa gttcaaatct ataatttttt tctcttcagt tctgttcttt gtatgataat
     6721 ccttaaaaaa gtagttgtct tcttttcaca tacacctctt taaagctatc atcttataat
     6781 aagtggaatt ggatgcttat tgtgtgccca gcacagttta ggaaaaaaat aattggcact
     6841 gtttgtccag ttactggaga tcttcatttt gatgctttgt actttgttcc aggtctttaa
     6901 ttctcagtcc atcttttcct atgattgtgt acttcacatg atacattcca tataaagagc
     6961 tcttttaaaa tgactatttc aaaaatactg tacatttata tatagtattt tttctcataa
     7021 aaatgtgata gtttatatat cctttcatca tacgtttttt ctaatgagtt tagatttctg
     7081 a
//
