LOCUS       NM_020935               8022 bp    mRNA    linear   PRI 09-FEB-2025
DEFINITION  Homo sapiens ubiquitin specific peptidase 37 (USP37), mRNA.
ACCESSION   NM_020935
VERSION     NM_020935.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 8022)
  AUTHORS   Piao,M. and Feng,G.
  TITLE     The deubiquitinating enzyme USP37 promotes keloid fibroblasts
            proliferation and collagen production by regulating the c-Myc
            expression
  JOURNAL   Int Wound J 20 (5), 1517-1524 (2023)
   PUBMED   36333840
  REMARK    GeneRIF: The deubiquitinating enzyme USP37 promotes keloid
            fibroblasts proliferation and collagen production by regulating the
            c-Myc expression.
REFERENCE   2  (bases 1 to 8022)
  AUTHORS   Chauhan,R., Gupta,A., Malhotra,L., Bhat,A.A., Pandita,R.K.,
            Masoodi,T., Dagar,G., Sadida,H.Q., Al-Marzooqi,S.K., Batra,A.,
            Bakhshi,S., Sharma,M.C., Tanwar,P., Khan,S.A., Samath,E.A.,
            Uddin,S., Akil,A.S.A., Haris,M., Macha,M.A., Pandita,T.K. and
            Singh,M.
  TITLE     Ubiquitin specific peptidase 37 and PCNA interaction promotes
            osteosarcoma pathogenesis by modulating replication fork
            progression
  JOURNAL   J Transl Med 21 (1), 286 (2023)
   PUBMED   37118828
  REMARK    GeneRIF: Ubiquitin specific peptidase 37 and PCNA interaction
            promotes osteosarcoma pathogenesis by modulating replication fork
            progression.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 8022)
  AUTHORS   Wu,C., Chang,Y., Chen,J., Su,Y., Li,L., Chen,Y., Li,Y., Wu,J.,
            Huang,J., Zhao,F., Wang,W., Yin,H., Wang,S., Jin,M., Lou,Z.,
            Zhu,W.G., Luo,K., Zhang,J. and Yuan,J.
  TITLE     USP37 regulates DNA damage response through stabilizing and
            deubiquitinating BLM
  JOURNAL   Nucleic Acids Res 49 (19), 11224-11240 (2021)
   PUBMED   34606619
  REMARK    GeneRIF: USP37 regulates DNA damage response through stabilizing
            and deubiquitinating BLM.
            Erratum:[Nucleic Acids Res. 2023 Mar 21;51(5):2496-2497. doi:
            10.1093/nar/gkad070.. PMID: 36744478]
REFERENCE   4  (bases 1 to 8022)
  AUTHORS   Qin,T., Cui,X.Y., Xiu,H., Huang,C., Sun,Z.N., Xu,X.M., Li,L.H. and
            Yue,L.
  TITLE     USP37 downregulation elevates the Chemical Sensitivity of Human
            Breast Cancer Cells to Adriamycin
  JOURNAL   Int J Med Sci 18 (2), 325-334 (2021)
   PUBMED   33390801
  REMARK    GeneRIF: USP37 downregulation elevates the Chemical Sensitivity of
            Human Breast Cancer Cells to Adriamycin.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 8022)
  AUTHORS   Hong,K., Hu,L., Liu,X., Simon,J.M., Ptacek,T.S., Zheng,X., Liao,C.,
            Baldwin,A.S. and Zhang,Q.
  TITLE     USP37 promotes deubiquitination of HIF2alpha in kidney cancer
  JOURNAL   Proc Natl Acad Sci U S A 117 (23), 13023-13032 (2020)
   PUBMED   32461361
  REMARK    GeneRIF: USP37 promotes deubiquitination of HIF2alpha in kidney
            cancer.
REFERENCE   6  (bases 1 to 8022)
  AUTHORS   Oguri,M., Kato,K., Yokoi,K., Yoshida,T., Watanabe,S., Metoki,N.,
            Yoshida,H., Satoh,K., Aoyagi,Y., Nozawa,Y. and Yamada,Y.
  TITLE     Assessment of a polymorphism of SDK1 with hypertension in Japanese
            Individuals
  JOURNAL   Am J Hypertens 23 (1), 70-77 (2010)
   PUBMED   19851296
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   7  (bases 1 to 8022)
  AUTHORS   Jin,J., Smith,F.D., Stark,C., Wells,C.D., Fawcett,J.P.,
            Kulkarni,S., Metalnikov,P., O'Donnell,P., Taylor,P., Taylor,L.,
            Zougman,A., Woodgett,J.R., Langeberg,L.K., Scott,J.D. and Pawson,T.
  TITLE     Proteomic, functional, and domain-based analysis of in vivo 14-3-3
            binding proteins involved in cytoskeletal regulation and cellular
            organization
  JOURNAL   Curr Biol 14 (16), 1436-1450 (2004)
   PUBMED   15324660
REFERENCE   8  (bases 1 to 8022)
  AUTHORS   Quesada,V., Diaz-Perales,A., Gutierrez-Fernandez,A., Garabaya,C.,
            Cal,S. and Lopez-Otin,C.
  TITLE     Cloning and enzymatic analysis of 22 novel human ubiquitin-specific
            proteases
  JOURNAL   Biochem Biophys Res Commun 314 (1), 54-62 (2004)
   PUBMED   14715245
REFERENCE   9  (bases 1 to 8022)
  AUTHORS   Puente,X.S., Sanchez,L.M., Overall,C.M. and Lopez-Otin,C.
  TITLE     Human and mouse proteases: a comparative genomic approach
  JOURNAL   Nat Rev Genet 4 (7), 544-558 (2003)
   PUBMED   12838346
  REMARK    Review article
REFERENCE   10 (bases 1 to 8022)
  AUTHORS   Simpson,J.C., Wellenreuther,R., Poustka,A., Pepperkok,R. and
            Wiemann,S.
  TITLE     Systematic subcellular localization of novel proteins identified by
            large-scale cDNA sequencing
  JOURNAL   EMBO Rep 1 (3), 287-292 (2000)
   PUBMED   11256614
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC012510.8 and AC073838.6.
            
            On Nov 23, 2018 this sequence version replaced NM_020935.2.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data because no single transcript was available
            for the full length of the gene. The extent of this transcript is
            supported by transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BX538024.1, SRR1803615.218684.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000258399.8/ ENSP00000258399.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-174               AC012510.8         15295-15468         c
            175-315             AC012510.8         9790-9930           c
            316-379             AC012510.8         7937-8000           c
            380-559             AC012510.8         5615-5794           c
            560-731             AC012510.8         670-841             c
            732-832             AC073838.6         104129-104229       c
            833-1005            AC073838.6         101239-101411       c
            1006-1083           AC073838.6         100541-100618       c
            1084-1181           AC073838.6         88929-89026         c
            1182-1266           AC073838.6         84276-84360         c
            1267-1428           AC073838.6         64299-64460         c
            1429-1560           AC073838.6         52346-52477         c
            1561-1684           AC073838.6         52054-52177         c
            1685-1875           AC073838.6         50080-50270         c
            1876-1993           AC073838.6         42624-42741         c
            1994-2073           AC073838.6         39984-40063         c
            2074-2238           AC073838.6         36390-36554         c
            2239-2304           AC073838.6         33970-34035         c
            2305-2446           AC073838.6         31160-31301         c
            2447-2702           AC073838.6         28950-29205         c
            2703-2869           AC073838.6         20330-20496         c
            2870-2930           AC073838.6         17626-17686         c
            2931-3046           AC073838.6         14110-14225         c
            3047-3116           AC073838.6         11412-11481         c
            3117-3255           AC073838.6         9900-10038          c
            3256-8022           AC073838.6         4571-9337           c
FEATURES             Location/Qualifiers
     source          1..8022
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2q35"
     gene            1..8022
                     /gene="USP37"
                     /note="ubiquitin specific peptidase 37"
                     /db_xref="GeneID:57695"
                     /db_xref="HGNC:HGNC:20063"
                     /db_xref="MIM:620226"
     exon            1..174
                     /gene="USP37"
                     /inference="alignment:Splign:2.1.0"
     exon            175..315
                     /gene="USP37"
                     /inference="alignment:Splign:2.1.0"
     exon            316..379
                     /gene="USP37"
                     /inference="alignment:Splign:2.1.0"
     exon            380..559
                     /gene="USP37"
                     /inference="alignment:Splign:2.1.0"
     CDS             404..3343
                     /gene="USP37"
                     /EC_number="3.4.19.12"
                     /note="ubiquitin specific protease 37; tmp_locus_50;
                     ubiquitin thioesterase 37; deubiquitinating enzyme 37;
                     ubiquitin-specific-processing protease 37; ubiquitin
                     thiolesterase 37"
                     /codon_start=1
                     /product="ubiquitin carboxyl-terminal hydrolase 37"
                     /protein_id="NP_065986.3"
                     /db_xref="CCDS:CCDS2418.1"
                     /db_xref="GeneID:57695"
                     /db_xref="HGNC:HGNC:20063"
                     /db_xref="MIM:620226"
                     /translation="MSPLKIHGPIRIRSMQTGITKWKEGSFEIVEKENKVSLVVHYNT
                     GGIPRIFQLSHNIKNVVLRPSGAKQSRLMLTLQDNSFLSIDKVPSKDAEEMRLFLDAV
                     HQNRLPAAMKPSQGSGSFGAILGSRTSQKETSRQLSYSDNQASAKRGSLETKDDIPFR
                     KVLGNPGRGSIKTVAGSGIARTIPSLTSTSTPLRSGLLENRTEKRKRMISTGSELNED
                     YPKENDSSSNNKAMTDPSRKYLTSSREKQLSLKQSEENRTSGLLPLQSSSFYGSRAGS
                     KEHSSGGTNLDRTNVSSQTPSAKRSLGFLPQPVPLSVKKLRCNQDYTGWNKPRVPLSS
                     HQQQQLQGFSNLGNTCYMNAILQSLFSLQSFANDLLKQGIPWKKIPLNALIRRFAHLL
                     VKKDICNSETKKDLLKKVKNAISATAERFSGYMQNDAHEFLSQCLDQLKEDMEKLNKT
                     WKTEPVSGEENSPDISATRAYTCPVITNLEFEVQHSIICKACGEIIPKREQFNDLSID
                     LPRRKKPLPPRSIQDSLDLFFRAEELEYSCEKCGGKCALVRHKFNRLPRVLILHLKRY
                     SFNVALSLNNKIGQQVIIPRYLTLSSHCTENTKPPFTLGWSAHMAISRPLKASQMVNS
                     CITSPSTPSKKFTFKSKSSLALCLDSDSEDELKRSVALSQRLCEMLGNEQQQEDLEKD
                     SKLCPIEPDKSELENSGFDRMSEEELLAAVLEISKRDASPSLSHEDDDKPTSSPDTGF
                     AEDDIQEMPENPDTMETEKPKTITELDPASFTEITKDCDENKENKTPEGSQGEVDWLQ
                     QYDMEREREEQELQQALAQSLQEQEAWEQKEDDDLKRATELSLQEFNNSFVDALGSDE
                     DSGNEDVFDMEYTEAEAEELKRNAETGNLPHSYRLISVVSHIGSTSSSGHYISDVYDI
                     KKQAWFTYNDLEVSKIQEAAVQSDRDRSGYIFFYMHKEIFDELLETEKNSQSLSTEVG
                     KTTRQAL"
     exon            560..731
                     /gene="USP37"
                     /inference="alignment:Splign:2.1.0"
     exon            732..832
                     /gene="USP37"
                     /inference="alignment:Splign:2.1.0"
     exon            833..1005
                     /gene="USP37"
                     /inference="alignment:Splign:2.1.0"
     exon            1006..1083
                     /gene="USP37"
                     /inference="alignment:Splign:2.1.0"
     exon            1084..1181
                     /gene="USP37"
                     /inference="alignment:Splign:2.1.0"
     exon            1182..1266
                     /gene="USP37"
                     /inference="alignment:Splign:2.1.0"
     exon            1267..1428
                     /gene="USP37"
                     /inference="alignment:Splign:2.1.0"
     exon            1429..1560
                     /gene="USP37"
                     /inference="alignment:Splign:2.1.0"
     exon            1561..1684
                     /gene="USP37"
                     /inference="alignment:Splign:2.1.0"
     exon            1685..1875
                     /gene="USP37"
                     /inference="alignment:Splign:2.1.0"
     exon            1876..1993
                     /gene="USP37"
                     /inference="alignment:Splign:2.1.0"
     exon            1994..2073
                     /gene="USP37"
                     /inference="alignment:Splign:2.1.0"
     exon            2074..2238
                     /gene="USP37"
                     /inference="alignment:Splign:2.1.0"
     exon            2239..2304
                     /gene="USP37"
                     /inference="alignment:Splign:2.1.0"
     exon            2305..2446
                     /gene="USP37"
                     /inference="alignment:Splign:2.1.0"
     exon            2447..2702
                     /gene="USP37"
                     /inference="alignment:Splign:2.1.0"
     exon            2703..2869
                     /gene="USP37"
                     /inference="alignment:Splign:2.1.0"
     exon            2870..2930
                     /gene="USP37"
                     /inference="alignment:Splign:2.1.0"
     exon            2931..3046
                     /gene="USP37"
                     /inference="alignment:Splign:2.1.0"
     exon            3047..3116
                     /gene="USP37"
                     /inference="alignment:Splign:2.1.0"
     exon            3117..3255
                     /gene="USP37"
                     /inference="alignment:Splign:2.1.0"
     exon            3256..8022
                     /gene="USP37"
                     /inference="alignment:Splign:2.1.0"
     regulatory      8001..8006
                     /regulatory_class="polyA_signal_sequence"
                     /gene="USP37"
                     /note="hexamer: ATTAAA"
     polyA_site      8022
                     /gene="USP37"
                     /note="major polyA site"
ORIGIN      
        1 gtttgcgtgt ggtcacagtt cccgccatca gccgctctcc ctgactaggg gtagctagcg
       61 gcctccctcc tttgggttcg gtatccctac ttccattacc ctcggctcct cccactcctc
      121 gcgggctccg tgctttccgc gggtctgtcc gggggctccg gaccctcggc gcagctgagt
      181 tgatggcttc cggagaactg gcatagctgc agaatatgag tagtgtccca agaagagtgc
      241 tttgcctttg gcacaaggat cagaataaag gtgaattgct attacatagg gtttttcggt
      301 aaaagtcact gaaaattatt tgccatacag taaccagaga cctccaacta ggggccccca
      361 aactgtatcc tgcctgtagc cagaagcaat ttttaaagaa aatatgtctc ctctgaagat
      421 acatggtcct atcagaattc gaagtatgca gactgggatt acaaagtgga aagaaggatc
      481 ctttgaaatt gtagaaaaag agaataaagt cagcctagta gttcactaca atactggagg
      541 aattccaagg atatttcagc taagtcataa cattaaaaat gtggtgcttc gacccagtgg
      601 agcgaaacaa agccgcctaa tgttaactct gcaagataac agcttcttgt ctattgacaa
      661 agtaccaagt aaggatgcag aggaaatgag gttgtttcta gatgcagtcc atcaaaacag
      721 acttcctgca gccatgaaac cgtctcaggg gtctggtagt tttggagcca ttctgggcag
      781 caggacctca cagaaggaaa ccagcaggca gctttcttac tcagacaatc aggcttctgc
      841 aaaaagagga agtttggaaa ctaaagatga tattccattt cgaaaagttc ttggtaatcc
      901 gggtagagga tcgattaaga ctgtagcagg aagtggaata gctcggacga ttccttcttt
      961 gacatctact tcaacacctc ttagatcagg gttgctagaa aatcgtactg aaaagaggaa
     1021 aagaatgata tcaactggct cagaattgaa tgaagattac cctaaggaaa atgattcatc
     1081 atcgaacaac aaggccatga cagatccctc cagaaagtat ttaaccagca gtagagaaaa
     1141 gcagctgagt ttgaaacagt cagaagagaa taggacatca gggcttttac ctttacagtc
     1201 atcatccttt tatggtagca gagctggatc caaggaacac tcttctggtg gcactaactt
     1261 agacaggact aatgtttcaa gccagactcc ctctgccaaa agaagtttgg gatttcttcc
     1321 tcagccagtt cctctttctg ttaaaaaact gaggtgtaac caggattaca ctggctggaa
     1381 taaaccaaga gtgccccttt cctctcacca acagcagcaa ctgcagggct tctccaattt
     1441 gggaaatacc tgctatatga atgctattct acaatctcta ttttcactcc agtcatttgc
     1501 aaatgacttg cttaaacaag gtatcccatg gaagaaaatt ccactcaatg cacttatcag
     1561 acgctttgca cacttgcttg ttaaaaaaga tatctgtaat tcagagacca aaaaggattt
     1621 actcaagaag gttaaaaatg ccatttcagc tacagcagag agattctctg gttatatgca
     1681 gaatgatgct catgaatttt taagtcagtg tttggaccag ctgaaagaag atatggaaaa
     1741 attaaataaa acttggaaga ctgaacctgt ttctggagaa gaaaattcac cagatatttc
     1801 agctaccaga gcatacactt gccctgttat tactaatttg gagtttgagg ttcagcactc
     1861 catcatttgt aaagcatgtg gagagattat ccccaaaaga gaacagttta atgacctctc
     1921 tattgacctt cctcgtagga aaaaaccact ccctcctcgt tcaattcaag attctcttga
     1981 tcttttcttt agggccgaag aactggagta ttcttgtgag aagtgtggtg ggaagtgtgc
     2041 tcttgtcagg cacaaattta acaggcttcc tagggtcctc attctccatt tgaaacgata
     2101 tagcttcaat gtggctctct cgcttaacaa taagattggg cagcaagtca tcattccaag
     2161 atacctgacc ctgtcatctc attgcactga aaatacaaaa ccacctttta cccttggttg
     2221 gagtgcacat atggcaattt ctagaccatt gaaagcctct caaatggtga attcctgcat
     2281 caccagccct tctacacctt caaagaaatt caccttcaaa tccaagagct ccttggcttt
     2341 atgccttgat tcagacagtg aggatgagct aaaacgttct gtggccctca gccagagact
     2401 ttgtgaaatg ttaggcaacg aacagcagca ggaagacctg gaaaaagatt caaaattatg
     2461 cccaatagag cctgacaagt ctgaattgga aaactcagga tttgacagaa tgagcgaaga
     2521 agagcttcta gcagctgtct tggagataag taagagagat gcttcaccat ctctgagtca
     2581 tgaagatgat gataagccaa ctagcagccc agataccgga tttgcagaag atgatattca
     2641 agaaatgcca gaaaatccag acactatgga aactgagaag cccaaaacaa tcacagagct
     2701 ggatcctgcc agttttactg agataactaa agactgtgat gagaataaag aaaacaaaac
     2761 tccagaagga tctcagggag aagttgattg gctccagcag tatgatatgg agcgtgaaag
     2821 ggaagagcaa gagcttcagc aggcactggc tcagagcctt caagagcaag aggcttggga
     2881 acagaaagaa gatgatgacc tcaaaagagc taccgagtta agtcttcaag agtttaacaa
     2941 ctcctttgtg gatgcattgg gttctgatga ggactctgga aatgaggatg tttttgatat
     3001 ggagtacaca gaagctgaag ctgaggaact gaaaagaaat gctgagacag gaaatctgcc
     3061 tcattcgtac cggctcatca gtgttgtcag tcacattggt agcacttctt cttcaggtca
     3121 ttacattagt gatgtatatg acattaagaa gcaagcgtgg tttacttaca atgacctgga
     3181 ggtatcaaaa atccaagagg ctgccgtgca gagtgatcga gatcggagtg gctacatctt
     3241 cttttatatg cacaaggaga tctttgatga gctgctggaa acagaaaaga actctcagtc
     3301 acttagcacg gaagtgggga agactacccg tcaggccttg tgaggaacaa actcctgggt
     3361 tggcagcatg cactgcatat ttgttactgc tgcccacctc acctttcctc tgctgaagga
     3421 gaatttggaa ttctacttga tgcgggagca acaaacagct cagggccaaa ccaaaagaca
     3481 aaaattggag taacgtagaa tgctccatgc tattttatgg aaactttggt ctcacatccg
     3541 tagctgatta tcctcttttt ctcctatgag tggcacttct tttgtcttag gaatacatgt
     3601 tgtaaatata tatctgtgta tgtgtgtata cacacacaca gacacacaca cacacacacg
     3661 ggatgaatgg agccttaaag agttaggatg agccaccaga atatgcctgc tcaaaattaa
     3721 tagcacagca gtttggagaa gaaatgaagg tgtcaaagag tccattcacc tgagaaatgt
     3781 gtgaagacat acttatcagt tggcttttag cttttatgtt ccttgagtag tttcactcaa
     3841 gtctgtaacc ttttgtgttt ccttattagt aaaattcact ggaaagccag ctcttcatgt
     3901 tacactaatg acagtttgtt ctctttgcaa gagaggggca ttactgtcac ctgacttgag
     3961 gagctgtttt gttgttgttg ttgtctgcaa atttcatgaa tttgtgatgt ctttgctgtt
     4021 tacatgcagt cccaagaaat ggattgttgg tgctttggaa tatgttacag tcccacattt
     4081 gatatttctt atatactttg ttttctctaa ggagatttct tcacacagta tgttcatcat
     4141 atatcatcat cattattatg gtggtaaaga tagaatcttt tttctttttt gtcattctgc
     4201 catggagcag cattacccta atggattgca accaaaactt taaacaagta gaaagataat
     4261 atttctccaa ttgggactcc ccagcaggaa tacttaggga taaggaagaa tgctagcatc
     4321 tctgtctctc aaacataggg aggataagaa gagtgttctt ctggtaaagc taaaattctg
     4381 gaccactgaa gctaaaagcc ctattgcaag tatgaaatta agtacttgag ctgtaggaca
     4441 aaccttgggc atttaaccat ttactgtctg gctttgccct taaaataggg ttgcaattaa
     4501 aatgtgattg gcttaggtaa tcccaaaaac taacaaataa caaaggtgca taatttattt
     4561 atctactttt taggtgctct gagttgaggc aaagtagagc ggcaacatta agtgctatgc
     4621 tagtcactta gctgacgtaa ccagcttggt taagcagctt atgaaaccat ataaagaatt
     4681 cttttgagga tggaattctg tccacaaaat aattttgtga gcccagatat cattaggatc
     4741 acacagagtt aaatatagaa aaatgaaacc atcattatat tctttcgtgt tttttctttt
     4801 attataaaca aggggattat tctttagttc tcagaggtag ggacaaaacc acatcaggtt
     4861 ttcagaagga aaaaacattt aaaaacccac catcacatga gagaatcact tgaacccagg
     4921 aggcagaggt tgcagtgagc tgagatcgca tcattgcact gcagtctgag tgacagagtg
     4981 agactccatc tcattaaaaa aaacgaaaac aaaaacaaaa aaaacacaaa ccatcatcac
     5041 agaagatgca acatcttttc tgaaagattg ccttaagaga gctccagtcc tactcttgga
     5101 acttggatgt attctaatgt agtaaactat tctaagtttt cattctttga attataaatg
     5161 gcctcagcag ttttgctcaa ctactgataa atgctttgcc tcctaccatc tacctatata
     5221 ccttattgta atgaatgttc caaaatggta gagtggtaga aaacgccaga gtagtttaga
     5281 gcagaggaaa atatttgttt taaaactagc tttaaagttt tgtttcattt ctaccaggag
     5341 cctctttggt ttggtttgat tttgcttgga aataattggt tttcttataa atgagtgaag
     5401 cggtgataaa attctttggc tagttattaa ttcttttacg tgtctttgca tttgagaggc
     5461 actgttaaaa attattggga aagatttaaa gtgcaggctg caattaaaac atggagaaaa
     5521 gtagaaataa tgccataagt ctagattgcc tcatgaagca gcctcatttg aattgctttc
     5581 atagctttca tgtgtgtatg gtttagaagt acacttacct cagaaacctg atttgatctt
     5641 catgtcttgg gcaggagttg ttgaaaatag gttattggaa tatataagtt atctcactgc
     5701 tcatgtactt gcatgtttgg gactcaaatt ttacttgatg tctgtccatt cttgtggccc
     5761 tatcagcctt ctccttcctt tactccttta atctacttct ttgactacca gtggagattt
     5821 cagctggact atgttgatgg ggtttgttgt tgtttttgag ctggctgtat atattttaaa
     5881 attataaata gataatatat tattttttgc acattgtgat cagtttgccc agaattgggg
     5941 atggggcagt tagcatgttg gggccaggaa gggacaagtt agataaggac tgagtgcttc
     6001 cgttgcaggc agtttgcaca atacctaatt aaccttccta ttgaaaatac caaatgtgtg
     6061 gttacattac tttaaatgac attgaattgg aacttgatgg caattagttc tagatacaac
     6121 cttttgatct ttgttggaat tttaagggaa aaatgaacta aacttcatat ttgttgattt
     6181 taatcaccta atagtactga aggttggaaa gttgcatgtg gctggatgct gttaatttct
     6241 ttaatagcca tgactataat ttaagcctat gagaagatag actgtttcgt agggatatat
     6301 tcacatgtgt gtgcacactc atgagttttg tctcagcagg atagaataag caaatccatg
     6361 aactggtctt ctattaatac tttgattcta aaaattattt gtttacttgc tatggtctgt
     6421 tcattctggg cctaacctta aaggctcaat aacaaataca acaaatgtaa atatgtttac
     6481 attttaagac atatgcagtg gttcttacag atcagttaat taactccaga aagcaaatgt
     6541 tagactacac atttattttt ctccttgatc aagtataaaa ttctgaaaca gaggctttaa
     6601 aatttaaaac ctcagcaaaa taatccatga atttactgat tcttctgtat cgtgtgtagt
     6661 taccattatg taactataca cacatacagc tacggatata atgaaaatta tctgcaaaca
     6721 cctaaattaa agagaaaaaa aagtagtttg taaactcatt tgtgatctac tgaaaagagg
     6781 ttatattaaa gcaaattaaa atattttcct tctctgtcct ctgaaatgac tgcagtagat
     6841 actcttagtt atcccattta gggtggttgg agggcctttt taatttaatt gaccccccga
     6901 ggtggtcttt tgttttaaac agggggcaac agctggatct ccaagtacat atggattttg
     6961 tatatatagg agatttttag aaaaatcaac aacctaacac cagattcaag tcacataaaa
     7021 gtgttccaat aaaatggatg gatgtctttt tcctccccat tttgctttat actgagtaat
     7081 gcactcttgc aagtgtatac aaaaactaaa tagacttctg ccctccaaca tctttttatt
     7141 gcattacttc aaaatcctaa ttttgtctct actgatatgt cttattaaca tctgaaaaaa
     7201 tatatatttt ttattggaaa attctaattt gttaggcctt gaaagttttg tgacaattat
     7261 tttgctgtgt ttaaccacaa tcattcacct tatggcatgc tttgattact agacttcagg
     7321 cagtctcatt cattgtatca tacttacaca caattagtaa gttgtctcca tgtgtgctat
     7381 atgtctgagg tgtatggagt ttttatttaa aaagtgtgcc agtctgaata taagcatttg
     7441 attttgtaac attggacttt tcttaaaagt acagaggttc aaagtatagg tatgtccatt
     7501 ggcataagaa tagagtgggt gagggtctgg accaggttcc aggttggtcc agtcagatgc
     7561 cagaacaaag aagaacagtc aactaaactg gtctacttca aaaatagtgg gcctgtgtga
     7621 agagtgagac cacatgtggg tgtgcacacc tcttgtcccc aggtttccct ccctttgagc
     7681 ttttctttcc ctccctaact tctctggcct attgtcattg ttgtttcttt aaacttaagg
     7741 agagaaaaac aaaaatgaga ttcctacact ttgcctaatt gagccactac caggttttct
     7801 ggcagctgtg gccacattat ttgtgagatg attttttttc tttatgttca gagtgacttt
     7861 tgattctgat tctttatgtt ttgtatggag cggcactttt atctgtgttt tagcagaact
     7921 gttcctctgt atcctttacg gtttttcttt gtttttgttt cctttttaaa ttatgcatag
     7981 agtttttttg tgtgtatgaa attaaagcct ttattaacct tc
//
