LOCUS       NM_001385174            5872 bp    mRNA    linear   PRI 12-NOV-2024
DEFINITION  Homo sapiens ubiquitin specific peptidase 36 (USP36), transcript
            variant 7, mRNA.
ACCESSION   NM_001385174 XM_005257542
VERSION     NM_001385174.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5872)
  AUTHORS   Li,Y., Yang,Y., Sears,R.C., Dai,M.S. and Sun,X.X.
  TITLE     USP36 SUMOylates Las1L and Promotes Its Function in Pre-Ribosomal
            RNA ITS2 Processing
  JOURNAL   Cancer Res Commun 4 (10), 2835-2845 (2024)
   PUBMED   39356143
  REMARK    GeneRIF: USP36 SUMOylates Las1L and Promotes Its Function in
            Pre-Ribosomal RNA ITS2 Processing.
REFERENCE   2  (bases 1 to 5872)
  AUTHORS   Zhuang,T., Zhang,S., Liu,D., Li,Z., Li,X., Li,J., Yang,P.,
            Zhang,C., Cui,J., Fu,M., Shen,F., Yuan,L., Zhang,Z., Su,P., Zhu,J.
            and Yang,H.
  TITLE     USP36 promotes tumorigenesis and tamoxifen resistance in breast
            cancer by deubiquitinating and stabilizing ERalpha
  JOURNAL   J Exp Clin Cancer Res 43 (1), 249 (2024)
   PUBMED   39215346
  REMARK    GeneRIF: USP36 promotes tumorigenesis and tamoxifen resistance in
            breast cancer by deubiquitinating and stabilizing ERalpha.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5872)
  AUTHORS   Yan,J., Gu,X., Gao,X., Shao,Y. and Ji,M.
  TITLE     USP36 regulates the proliferation, survival, and differentiation of
            hFOB1.19 osteoblast
  JOURNAL   J Orthop Surg Res 19 (1), 483 (2024)
   PUBMED   39152465
  REMARK    GeneRIF: USP36 regulates the proliferation, survival, and
            differentiation of hFOB1.19 osteoblast.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 5872)
  AUTHORS   Gao,B., Qiao,Y., Zhu,S., Yang,N., Zou,S.S., Liu,Y.J. and Chen,J.
  TITLE     USP36 inhibits apoptosis by deubiquitinating cIAP1 and survivin in
            colorectal cancer cells
  JOURNAL   J Biol Chem 300 (7), 107463 (2024)
   PUBMED   38876304
  REMARK    GeneRIF: USP36 inhibits apoptosis by deubiquitinating cIAP1 and
            survivin in colorectal cancer cells.
REFERENCE   5  (bases 1 to 5872)
  AUTHORS   Guan,S., Chen,X., Wei,Y., Wang,F., Xie,W., Chen,Y., Liang,H.,
            Zhu,X., Yang,Y., Fang,W., Huang,Y., Zhao,H., Zhang,X., Liu,S.,
            Zhuang,W., Huang,M., Wang,X. and Zhang,L.
  TITLE     Germline USP36 Mutation Confers Resistance to EGFR-TKIs by
            Upregulating MLLT3 Expression in Patients with Non-Small Cell Lung
            Cancer
  JOURNAL   Clin Cancer Res 30 (7), 1382-1396 (2024)
   PUBMED   38261467
  REMARK    GeneRIF: Germline USP36 Mutation Confers Resistance to EGFR-TKIs by
            Upregulating MLLT3 Expression in Patients with Non-Small Cell Lung
            Cancer.
REFERENCE   6  (bases 1 to 5872)
  AUTHORS   Andersen,J.S., Lam,Y.W., Leung,A.K., Ong,S.E., Lyon,C.E.,
            Lamond,A.I. and Mann,M.
  TITLE     Nucleolar proteome dynamics
  JOURNAL   Nature 433 (7021), 77-83 (2005)
   PUBMED   15635413
REFERENCE   7  (bases 1 to 5872)
  AUTHORS   Kim,M.S., Yoo,K.J., Kang,I., Chung,H.M. and Baek,K.H.
  TITLE     A novel cysteine protease HeLa DUB-1 responsible for cleaving the
            ubiquitin in human ovarian cancer cells
  JOURNAL   Int J Oncol 25 (2), 373-379 (2004)
   PUBMED   15254734
  REMARK    GeneRIF: DUB-1 is present ubuquitously within cells and has
            deubiitinating enzyme activity in vivo and in vitro.
REFERENCE   8  (bases 1 to 5872)
  AUTHORS   Quesada,V., Diaz-Perales,A., Gutierrez-Fernandez,A., Garabaya,C.,
            Cal,S. and Lopez-Otin,C.
  TITLE     Cloning and enzymatic analysis of 22 novel human ubiquitin-specific
            proteases
  JOURNAL   Biochem Biophys Res Commun 314 (1), 54-62 (2004)
   PUBMED   14715245
REFERENCE   9  (bases 1 to 5872)
  AUTHORS   Puente,X.S., Sanchez,L.M., Overall,C.M. and Lopez-Otin,C.
  TITLE     Human and mouse proteases: a comparative genomic approach
  JOURNAL   Nat Rev Genet 4 (7), 544-558 (2003)
   PUBMED   12838346
  REMARK    Review article
REFERENCE   10 (bases 1 to 5872)
  AUTHORS   Scherl,A., Coute,Y., Deon,C., Calle,A., Kindbeiter,K.,
            Sanchez,J.C., Greco,A., Hochstrasser,D. and Diaz,J.J.
  TITLE     Functional proteomic analysis of human nucleolus
  JOURNAL   Mol Biol Cell 13 (11), 4100-4109 (2002)
   PUBMED   12429849
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC022966.13.
            
            On Jul 8, 2020 this sequence version replaced XM_005257542.3.
            
            Summary: This gene encodes a member of the peptidase C19 or
            ubiquitin-specific protease family of cysteine proteases. Members
            of this family remove ubiquitin molecules from polyubiquitinated
            proteins. The encoded protein may deubiquitinate and stabilize the
            transcription factor c-Myc, also known as MYC, an important
            oncoprotein known to be upregulated in most human cancers. The
            encoded protease may also regulate the activation of autophagy.
            This gene exhibits elevated expression in some breast and lung
            cancers. [provided by RefSeq, Mar 2016].
            
            Transcript Variant: This variant (7), as well as variants 2-6, 8,
            and 9, encodes isoform 2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR11853564.12851.1,
                                           SRR11853563.15039.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000449938.7/ ENSP00000401119.4
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-79                AC022966.13        147608-147686       c
            80-243              AC022966.13        145459-145622       c
            244-505             AC022966.13        142983-143244       c
            506-727             AC022966.13        142152-142373       c
            728-838             AC022966.13        135769-135879       c
            839-941             AC022966.13        134117-134219       c
            942-1009            AC022966.13        128809-128876       c
            1010-1080           AC022966.13        127863-127933       c
            1081-1163           AC022966.13        126802-126884       c
            1164-1275           AC022966.13        125539-125650       c
            1276-1416           AC022966.13        121284-121424       c
            1417-1517           AC022966.13        120645-120745       c
            1518-1659           AC022966.13        119732-119873       c
            1660-2337           AC022966.13        113831-114508       c
            2338-2468           AC022966.13        113028-113158       c
            2469-3062           AC022966.13        110257-110850       c
            3063-3274           AC022966.13        109196-109407       c
            3275-3376           AC022966.13        106539-106640       c
            3377-3492           AC022966.13        105780-105895       c
            3493-3644           AC022966.13        105272-105423       c
            3645-5872           AC022966.13        102524-104751       c
FEATURES             Location/Qualifiers
     source          1..5872
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q25.3"
     gene            1..5872
                     /gene="USP36"
                     /gene_synonym="DUB1"
                     /note="ubiquitin specific peptidase 36"
                     /db_xref="GeneID:57602"
                     /db_xref="HGNC:HGNC:20062"
                     /db_xref="MIM:612543"
     exon            1..79
                     /gene="USP36"
                     /gene_synonym="DUB1"
                     /inference="alignment:Splign:2.1.0"
     exon            80..243
                     /gene="USP36"
                     /gene_synonym="DUB1"
                     /inference="alignment:Splign:2.1.0"
     exon            244..505
                     /gene="USP36"
                     /gene_synonym="DUB1"
                     /inference="alignment:Splign:2.1.0"
     CDS             253..3624
                     /gene="USP36"
                     /gene_synonym="DUB1"
                     /EC_number="3.4.19.12"
                     /note="isoform 2 is encoded by transcript variant 7;
                     ubiquitin specific protease 36; ubiquitin
                     carboxyl-terminal hydrolase 36; ubiquitin thioesterase 36;
                     deubiquitinating enzyme 36; ubiquitin-specific-processing
                     protease 36"
                     /codon_start=1
                     /product="ubiquitin carboxyl-terminal hydrolase 36 isoform
                     2"
                     /protein_id="NP_001372103.1"
                     /db_xref="CCDS:CCDS32755.1"
                     /db_xref="GeneID:57602"
                     /db_xref="HGNC:HGNC:20062"
                     /db_xref="MIM:612543"
                     /translation="MPIVDKLKEALKPGRKDSADDGELGKLLASSAKKVLLQKIEFEP
                     ASKSFSYQLEALKSKYVLLNPKTEGASRHKSGDDPPARRQGSEHTYESCGDGVPAPQK
                     VLFPTERLSLRWERVFRVGAGLHNLGNTCFLNATIQCLTYTPPLANYLLSKEHARSCH
                     QGSFCMLCVMQNHIVQAFANSGNAIKPVSFIRDLKKIARHFRFGNQEDAHEFLRYTID
                     AMQKACLNGCAKLDRQTQATTLVHQIFGGYLRSRVKCSVCKSVSDTYDPYLDVALEIR
                     QAANIVRALELFVKADVLSGENAYMCAKCKKKVPASKRFTIHRTSNVLTLSLKRFANF
                     SGGKITKDVGYPEFLNIRPYMSQNNGDPVMYGLYAVLVHSGYSCHAGHYYCYVKASNG
                     QWYQMNDSLVHSSNVKVVLNQQAYVLFYLRIPGSKKSPEGLISRTGSSSLPGRPSVIP
                     DHSKKNIGNGIISSPLTGKRQDSGTMKKPHTTEEIGVPISRNGSTLGLKSQNGCIPPK
                     LPSGSPSPKLSQTPTHMPTILDDPGKKVKKPAPPQHFSPRTAQGLPGTSNSNSSRSGS
                     QRQGSWDSRDVVLSTSPKLLATATANGHGLKGNDESAGLDRRGSSSSSPEHSASSDST
                     KAPQTPRSGAAHLCDSQETNCSTAGHSKTPPSGADSKTVKLKSPVLSNTTTEPASTMS
                     PPPAKKLALSAKKASTLWRATGNDLRPPPPSPSSDLTHPMKTSHPVVASTWPVHRARA
                     VSPAPQSSSRLQPPFSPHPTLLSSTPKPPGTSEPRSCSSISTALPQVNEDLVSLPHQL
                     PEASEPPQSPSEKRKKTFVGEPQRLGSETRLPQHIREATAAPHGKRKRKKKKRPEDTA
                     ASALQEGQTQRQPGSPMYRREGQAQLPAVRRQEDGTQPQVNGQQVGCVTDGHHASSRK
                     RRRKGAEGLGEEGGLHQDPLRHSCSPMGDGDPEAMEESPRKKKKKKRKQETQRAVEED
                     GHLKCPRSAKPQDAVVPESSSCAPSANGWCPGDRMGLSQAPPVSWNGERESDVVQELL
                     KYSSDKAYGRKVLTWDGKMSAVSQDAIEDSRQARTETVVDDWDEEFDRGKEKKIKKFK
                     REKRRNFNAFQKLQTRRNFWSVTHPAKAASLSYRR"
     exon            506..727
                     /gene="USP36"
                     /gene_synonym="DUB1"
                     /inference="alignment:Splign:2.1.0"
     exon            728..838
                     /gene="USP36"
                     /gene_synonym="DUB1"
                     /inference="alignment:Splign:2.1.0"
     exon            839..941
                     /gene="USP36"
                     /gene_synonym="DUB1"
                     /inference="alignment:Splign:2.1.0"
     exon            942..1009
                     /gene="USP36"
                     /gene_synonym="DUB1"
                     /inference="alignment:Splign:2.1.0"
     exon            1010..1080
                     /gene="USP36"
                     /gene_synonym="DUB1"
                     /inference="alignment:Splign:2.1.0"
     exon            1081..1163
                     /gene="USP36"
                     /gene_synonym="DUB1"
                     /inference="alignment:Splign:2.1.0"
     exon            1164..1275
                     /gene="USP36"
                     /gene_synonym="DUB1"
                     /inference="alignment:Splign:2.1.0"
     exon            1276..1416
                     /gene="USP36"
                     /gene_synonym="DUB1"
                     /inference="alignment:Splign:2.1.0"
     exon            1417..1517
                     /gene="USP36"
                     /gene_synonym="DUB1"
                     /inference="alignment:Splign:2.1.0"
     exon            1518..1659
                     /gene="USP36"
                     /gene_synonym="DUB1"
                     /inference="alignment:Splign:2.1.0"
     exon            1660..2337
                     /gene="USP36"
                     /gene_synonym="DUB1"
                     /inference="alignment:Splign:2.1.0"
     exon            2338..2468
                     /gene="USP36"
                     /gene_synonym="DUB1"
                     /inference="alignment:Splign:2.1.0"
     exon            2469..3062
                     /gene="USP36"
                     /gene_synonym="DUB1"
                     /inference="alignment:Splign:2.1.0"
     exon            3063..3274
                     /gene="USP36"
                     /gene_synonym="DUB1"
                     /inference="alignment:Splign:2.1.0"
     exon            3275..3376
                     /gene="USP36"
                     /gene_synonym="DUB1"
                     /inference="alignment:Splign:2.1.0"
     exon            3377..3492
                     /gene="USP36"
                     /gene_synonym="DUB1"
                     /inference="alignment:Splign:2.1.0"
     exon            3493..3644
                     /gene="USP36"
                     /gene_synonym="DUB1"
                     /inference="alignment:Splign:2.1.0"
     exon            3645..5872
                     /gene="USP36"
                     /gene_synonym="DUB1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5850..5855
                     /regulatory_class="polyA_signal_sequence"
                     /gene="USP36"
                     /gene_synonym="DUB1"
                     /note="hexamer: AATAAA"
     polyA_site      5872
                     /gene="USP36"
                     /gene_synonym="DUB1"
                     /note="major polyA site"
ORIGIN      
        1 atggtgcgcg tgctgggccg cgggccgaag gagtcgccag ggctgcgtag gcttgtggcg
       61 cgcccgcgga gaggccgggg ctctgacgcc cgctctgcgg cttcggtgtt tgaacaggcc
      121 acagtccagg agcgcttaca ttcaggagct ccgcgtagca cctgcccaac caaactcagc
      181 cctccgttaa gatcctggtt ccatgccgca gtaggacagc aggcccaagt ctgcacatcc
      241 cagtgatgca ccatgccaat agtggataag ttgaaggagg ccctgaaacc cggccgcaag
      301 gactcggctg atgatggaga actggggaag cttcttgcct cctctgccaa gaaggtcctt
      361 ttacagaaaa tcgagttcga gccagccagc aagagcttct cctaccagct ggaggcctta
      421 aagagcaaat atgtgttgct caaccccaaa acagagggag ctagtcgcca caagagtgga
      481 gatgacccac cggccaggag acagggcagt gagcacacgt atgagagctg tggtgacgga
      541 gtcccagccc cgcagaaagt gcttttcccc acggagcgac tgtctctgag gtgggagcgg
      601 gtcttccgcg tgggcgcagg actccacaac cttggcaaca cctgctttct caatgccacc
      661 atccagtgct tgacctacac accacctcta gccaactacc tgctctccaa ggagcatgct
      721 cgcagctgcc accagggaag cttctgcatg ctgtgtgtca tgcagaacca cattgtccag
      781 gccttcgcca acagcggcaa cgccatcaag cccgtctcct tcatccgaga cctgaaaaag
      841 atcgcccgac acttccgctt tgggaaccag gaggacgcgc atgagttcct gcggtacacc
      901 atcgacgcca tgcagaaagc ctgcctgaat ggctgtgcca agttggatcg tcaaacgcag
      961 gctactacct tggtccatca aatttttgga gggtatctca gatcacgcgt gaagtgctcc
     1021 gtgtgcaaga gcgtctcgga cacctacgac ccctacttgg acgtcgcgct ggagatccgg
     1081 caagctgcga atattgtgcg tgctctggaa ctttttgtga aagcagatgt cctgagtgga
     1141 gagaatgcct acatgtgtgc taaatgcaag aagaaggttc cagccagcaa gcgcttcacc
     1201 atccacagaa catccaacgt cttaaccctt tccctcaagc gctttgccaa cttcagcggg
     1261 gggaagatca ccaaggatgt aggctatccg gaattcctca acatacgtcc gtatatgtcc
     1321 cagaataatg gtgatcctgt catgtatgga ctctatgctg tcctggtgca ctcgggctac
     1381 agctgccatg ccgggcacta ttactgctac gtgaaggcaa gcaatggaca gtggtaccag
     1441 atgaatgatt ccttggtcca ttccagcaac gtcaaggtgg ttctgaacca gcaggcctac
     1501 gtgctgttct atctgcgaat tccaggctct aagaaaagtc ccgagggcct catctccagg
     1561 acaggctcct cctcccttcc cggccgcccg agtgtgattc cagatcactc caagaagaac
     1621 atcggcaatg ggattatttc ctccccactg actggaaagc gacaagactc tgggacgatg
     1681 aagaagccgc acaccactga agagattggt gtgcccatat ccaggaatgg ctccaccctg
     1741 ggcctgaagt cccagaacgg ctgcattcct ccaaagctgc cctcggggtc cccttccccc
     1801 aaactctccc agacacccac acacatgcca accatcctag acgaccctgg aaagaaggtg
     1861 aagaagccag ctcctccaca gcacttttcc cccagaactg ctcaggggct gcctgggacc
     1921 agcaactcga atagcagcag atctgggagc caaaggcagg gctcctggga cagcagggat
     1981 gttgtcctct ctacctcacc taagctcctg gctacagcca ctgccaacgg gcatgggctg
     2041 aaggggaacg acgagagcgc tggcctcgac aggaggggct ccagcagctc cagcccagag
     2101 cactcggcca gcagcgactc caccaaggcc ccccagaccc ccaggagtgg agcggcccat
     2161 ctctgcgatt ctcaggaaac gaactgttcc accgctggcc actccaaaac gccgccaagt
     2221 ggagcagatt ctaagacggt gaagctgaag tcccctgtcc tgagcaacac caccactgag
     2281 cctgcaagca ccatgtctcc tccaccagcc aaaaaactgg ccctttctgc caagaaggcc
     2341 agcaccctgt ggagggcgac cggcaatgac ctccgtccac ctcccccctc accatcctcc
     2401 gacctcaccc accccatgaa aacctctcac cccgtcgttg cctccacttg gcccgtccat
     2461 agagccaggg ctgtgtcacc tgctccccaa tcatccagcc gcctgcaacc ccccttcagc
     2521 ccccacccca cattgctgtc cagtaccccc aagcccccag ggacgtcaga accacggagc
     2581 tgctcctcca tctcgacggc gctgcctcag gtcaacgagg accttgtgtc tcttccacac
     2641 cagttgccag aggccagtga gcccccccag agcccctctg agaagaggaa aaagaccttt
     2701 gtgggagagc cgcagaggct gggctcagag acgcgcctcc cacagcacat cagggaggcc
     2761 actgcggctc cccacgggaa gaggaagagg aagaagaaga agcgcccgga ggacacagct
     2821 gccagcgccc tgcaggaggg gcagacacag agacagcctg ggagccccat gtacaggagg
     2881 gagggccagg cacagctgcc cgctgtcaga cggcaggaag atggcacaca gccacaggtg
     2941 aatggccagc aggtgggatg tgttacggac ggccaccacg cgagcagcag gaagcggagg
     3001 aggaaaggag cagaaggtct tggtgaagaa ggcggcctgc accaggaccc acttcggcac
     3061 agctgctctc ccatgggtga tggtgatcca gaggccatgg aagagtctcc aaggaaaaag
     3121 aaaaagaaaa aaagaaagca ggagacacag cgggcagtag aagaggatgg gcatctcaaa
     3181 tgcccaagga gtgccaagcc ccaagatgct gttgtccccg agtccagcag ctgcgcacca
     3241 tccgcgaatg gctggtgtcc tggggaccgc atggggctga gccaggcccc tcctgtgtct
     3301 tggaatggag agcgggagtc tgatgtggtc caggaactgc tcaaatactc atctgataaa
     3361 gcttacggga gaaaagttct gacctgggat ggcaagatgt cggcggtcag tcaggatgct
     3421 attgaagaca gcagacaggc ccggactgag accgtggttg atgactggga cgaagagttt
     3481 gaccgaggga aggaaaagaa aattaaaaaa tttaagagag agaagaggag aaacttcaac
     3541 gccttccaga aacttcagac tcgacggaac ttctggtctg tgactcaccc agcaaaggct
     3601 gccagcctca gctatcgccg ctgactgtgc ccctgtggaa ggagcctcct ggagacaagg
     3661 cgtcccttcc cgggagctgt cggtctggat ctgagggagc tctctgtgtg ggctctgctg
     3721 cgctgggagc ctgtcacggt aggagctctc ccggtaccag tgtccacaga ccgcccaaca
     3781 cagaggcttt gaggcttctc tagatcggaa cctctttggt gacattcccg accagccctg
     3841 caagagaaac gacagtgtgt gtgtgagcag aggtggccgc acacctgctg gacatctttg
     3901 ccaggctgtg ccttctcatg tttcatagac agtggtctgt gctggcagag gctgctgccc
     3961 ctggttgggg ctatcaggag agtgggggat ggtggccaca tgtcccccag gtggtctccc
     4021 ggtgcatagc tggtggctct gggcaagcca tcccttgctt ctcggggctg acgccaccgt
     4081 tgtgtccgag cccgccctcc cctgcttcct cagcgggacc ccttcatctg ttggccttac
     4141 ctgtcctcag aaaggaagag gtgaccccac ccagccacct ctccctttta tggaactcga
     4201 gagggtggcc ctactgtgca ccccttcctt gtgagtagct ctcaactgtc ctggagagca
     4261 gaggctattt ggggtcggag gagccctcga tacctgcgaa tacatctgct ttccaggctg
     4321 ctgtttattc tgagacgact gtgctgtagc ttcccttgca gctgcaataa cccgcaggtc
     4381 ttcactgagg tggaggcttt ggggtagaat tctccattta ttttactact taatacaaaa
     4441 catttatttt tgaccagtcc tgtggcttcc attagcaata tgtttccttt cccaaatatg
     4501 caaatagtgg ctttgtttgc tcaattttgt gagtgctttg gaatttaaat gattgtataa
     4561 ctcaagaaga ttacttttct atgttgctca agctgtgcct gccaacttgt aacttaataa
     4621 atacaggaaa tcctcagaga aggtgatatt ttcaggaaaa agacaaatgc cctcatagta
     4681 gtgggaagtg tgaaggtgac cgtgaacatc cttcctcatc gggtctgtcc ccgtcatttc
     4741 ctcccggagt cgtcgcaggt ggagatggac aacgtggtgt tggacttaga cctccttcag
     4801 tgtggctctg ctgggccaga ggcatcctgc tgtcccgggt ggctgcctcg ctgtctgcac
     4861 cccctctccc tggggcagct ttgcttcctg cccctgtgct cggggcctgg gtggttactg
     4921 gcgtgtagat ggaattgctt ttttaatatg ggaagataca tttatttttt tccatgtggg
     4981 tgggtgtctc tttttggatt ttcttctgtt tttacgtttc tcttcttaga agggtgggag
     5041 agaatcaagc tcctgtggcc acctgtgtcc cagcagcagt gagtggagct gctcagggtg
     5101 ccctctcctg cggaccagtc tctgaatgtt caaagatgag ggcctggctt ccgtgctctg
     5161 gctttgtaac ttatctggaa gggaaagcac atgccttcac gggcagggta tgttcctttt
     5221 cttctcgggg tgttgacttg cattcctgtg tgaactgttc cctctgccat gtttaccgtg
     5281 tgatgttctg tagttgaaaa tgttagttgt ctgctggcac agaatttatc tcgttccttt
     5341 ctctcccttc tctcctccaa atcagtctct tcccttctcc actagataac tgtaaaacct
     5401 tttcctgggg tacatacatt cgttaactct tgggcagtgg tgagcacgag atgactttct
     5461 gcagcgttta tcactgttgg gtggagtcac gtcccttccc tccaccgaag tcatcaacca
     5521 gatagggaag ggaaagatga ggcccagaaa acgagttcaa actctaggtc ttgtacacgt
     5581 atgtaagtaa atgtcaataa cccaagcctt tgtcatagca gtcacttggt tgacttagga
     5641 tctgggtctg ttgaattttg tgcttgggaa tggagctgga gggagtgggg cctgtgtaca
     5701 gcagctacct ctcccaggtc ctctcacttg cctgccccgc gtcctggttg catggccgca
     5761 cctgtgtgtg tgcagaggtc tgtgtcccat cctctgcacc tcctttccgg gggcctgggg
     5821 agccccacgt gttgccaaga tcttggtgca ataaaatact ccggttttgt ga
//
