LOCUS       NM_020798               4725 bp    mRNA    linear   PRI 23-SEP-2024
DEFINITION  Homo sapiens ubiquitin specific peptidase 35 (USP35), mRNA.
ACCESSION   NM_020798 XM_290527 XM_935134 XM_942438 XM_945970
VERSION     NM_020798.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4725)
  AUTHORS   Ma,C., Tian,Z., Wang,D., Gao,W., Qian,L., Zang,Y., Xu,X., Jia,J.
            and Liu,Z.
  TITLE     Ubiquitin-specific Protease 35 Promotes Gastric Cancer Metastasis
            by Increasing the Stability of Snail1
  JOURNAL   Int J Biol Sci 20 (3), 953-967 (2024)
   PUBMED   38250150
  REMARK    GeneRIF: Ubiquitin-specific Protease 35 Promotes Gastric Cancer
            Metastasis by Increasing the Stability of Snail1.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4725)
  AUTHORS   Lv,T., Zhang,B., Jiang,C., Zeng,Q., Yang,J. and Zhou,Y.
  TITLE     USP35 promotes hepatocellular carcinoma progression by protecting
            PKM2 from ubiquitination-mediated degradation
  JOURNAL   Int J Oncol 63 (4) (2023)
   PUBMED   37594129
  REMARK    GeneRIF: USP35 promotes hepatocellular carcinoma progression by
            protecting PKM2 from ubiquitination-mediated degradation.
REFERENCE   3  (bases 1 to 4725)
  AUTHORS   Wang,S., Wang,T., Zhang,X., Cheng,S., Chen,C., Yang,G., Wang,F.,
            Wang,R., Zhang,Q., Yang,D., Zhang,Y., Liu,S., Qin,H., Liu,Q. and
            Liu,H.
  TITLE     The deubiquitylating enzyme USP35 restricts regulated cell death to
            promote survival of renal clear cell carcinoma
  JOURNAL   Cell Death Differ 30 (7), 1757-1770 (2023)
   PUBMED   37173391
  REMARK    GeneRIF: The deubiquitylating enzyme USP35 restricts regulated cell
            death to promote survival of renal clear cell carcinoma.
REFERENCE   4  (bases 1 to 4725)
  AUTHORS   Wang,W., Wang,M., Xiao,Y., Wang,Y., Ma,L., Guo,L., Wu,X., Lin,X.
            and Zhang,P.
  TITLE     USP35 mitigates endoplasmic reticulum stress-induced apoptosis by
            stabilizing RRBP1 in non-small cell lung cancer
  JOURNAL   Mol Oncol 16 (7), 1572-1590 (2022)
   PUBMED   34618999
  REMARK    GeneRIF: USP35 mitigates endoplasmic reticulum stress-induced
            apoptosis by stabilizing RRBP1 in non-small cell lung cancer.
REFERENCE   5  (bases 1 to 4725)
  AUTHORS   Wang,W., Lin,H., Zheng,E., Hou,Z., Liu,Y., Huang,W., Chen,D.,
            Feng,J., Li,J. and Li,L.
  TITLE     Regulation of survivin protein stability by USP35 is evolutionarily
            conserved
  JOURNAL   Biochem Biophys Res Commun 574, 48-55 (2021)
   PUBMED   34438346
  REMARK    GeneRIF: Regulation of survivin protein stability by USP35 is
            evolutionarily conserved.
REFERENCE   6  (bases 1 to 4725)
  AUTHORS   Bailey,S.D., Xie,C., Do,R., Montpetit,A., Diaz,R., Mohan,V.,
            Keavney,B., Yusuf,S., Gerstein,H.C., Engert,J.C. and Anand,S.
  CONSRTM   DREAM investigators
  TITLE     Variation at the NFATC2 locus increases the risk of
            thiazolidinedione-induced edema in the Diabetes REduction
            Assessment with ramipril and rosiglitazone Medication (DREAM) study
  JOURNAL   Diabetes Care 33 (10), 2250-2253 (2010)
   PUBMED   20628086
  REMARK    GeneRIF: Observational study of gene-disease association,
            gene-environment interaction, and pharmacogenomic / toxicogenomic.
            (HuGE Navigator)
REFERENCE   7  (bases 1 to 4725)
  AUTHORS   Davila,S., Froeling,F.E., Tan,A., Bonnard,C., Boland,G.J.,
            Snippe,H., Hibberd,M.L. and Seielstad,M.
  TITLE     New genetic associations detected in a host response study to
            hepatitis B vaccine
  JOURNAL   Genes Immun 11 (3), 232-238 (2010)
   PUBMED   20237496
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   8  (bases 1 to 4725)
  AUTHORS   Talmud,P.J., Drenos,F., Shah,S., Shah,T., Palmen,J., Verzilli,C.,
            Gaunt,T.R., Pallas,J., Lovering,R., Li,K., Casas,J.P., Sofat,R.,
            Kumari,M., Rodriguez,S., Johnson,T., Newhouse,S.J., Dominiczak,A.,
            Samani,N.J., Caulfield,M., Sever,P., Stanton,A., Shields,D.C.,
            Padmanabhan,S., Melander,O., Hastie,C., Delles,C., Ebrahim,S.,
            Marmot,M.G., Smith,G.D., Lawlor,D.A., Munroe,P.B., Day,I.N.,
            Kivimaki,M., Whittaker,J., Humphries,S.E. and Hingorani,A.D.
  CONSRTM   ASCOT investigators; NORDIL investigators; BRIGHT Consortium
  TITLE     Gene-centric association signals for lipids and apolipoproteins
            identified via the HumanCVD BeadChip
  JOURNAL   Am J Hum Genet 85 (5), 628-642 (2009)
   PUBMED   19913121
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   9  (bases 1 to 4725)
  AUTHORS   Quesada,V., Diaz-Perales,A., Gutierrez-Fernandez,A., Garabaya,C.,
            Cal,S. and Lopez-Otin,C.
  TITLE     Cloning and enzymatic analysis of 22 novel human ubiquitin-specific
            proteases
  JOURNAL   Biochem Biophys Res Commun 314 (1), 54-62 (2004)
   PUBMED   14715245
REFERENCE   10 (bases 1 to 4725)
  AUTHORS   Puente,X.S., Sanchez,L.M., Overall,C.M. and Lopez-Otin,C.
  TITLE     Human and mouse proteases: a comparative genomic approach
  JOURNAL   Nat Rev Genet 4 (7), 544-558 (2003)
   PUBMED   12838346
  REMARK    Review article
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK056231.1, CN287538.1,
            AJ586137.1, DB095282.1, AB037793.1, AP002985.2 and AI263341.1.
            
            On Nov 23, 2018 this sequence version replaced NM_020798.3.
            
            Summary: This gene encodes a member of the peptidase C19 family of
            ubiquitin-specific proteases. These deubiquitinating enzymes (DUBs)
            catalyze the removal of ubiquitin proteins from other proteins. The
            encoded protein associates with polarized mitochondria and has been
            shown to inhibit NF-kappa B activation and delay PARK2-mediated
            degradation of mitochondria. Expression of this gene is upregulated
            by the let-7a microRNA and reduced expression has been observed in
            human tumor tissues. [provided by RefSeq, Jul 2017].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA1965299,
                              SAMEA1968540 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000529308.6/ ENSP00000431876.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-8                 AK056231.1         108-115
            9-249               CN287538.1         21-261
            250-637             AJ586137.1         1-388
            638-1204            DB095282.1         1-567
            1205-1636           AJ586137.1         953-1384
            1637-3870           AB037793.1         1207-3440
            3871-4666           AP002985.2         68742-69537
            4667-4725           AI263341.1         14-72               c
FEATURES             Location/Qualifiers
     source          1..4725
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q14.1"
     gene            1..4725
                     /gene="USP35"
                     /note="ubiquitin specific peptidase 35"
                     /db_xref="GeneID:57558"
                     /db_xref="HGNC:HGNC:20061"
                     /db_xref="MIM:620959"
     exon            1..239
                     /gene="USP35"
                     /inference="alignment:Splign:2.1.0"
     exon            240..922
                     /gene="USP35"
                     /inference="alignment:Splign:2.1.0"
     CDS             250..3306
                     /gene="USP35"
                     /EC_number="3.4.19.12"
                     /note="ubiquitin specific protease 35; ubiquitin
                     thioesterase 35; deubiquitinating enzyme 35;
                     ubiquitin-specific-processing protease 35; ubiquitin
                     thiolesterase 35"
                     /codon_start=1
                     /product="ubiquitin carboxyl-terminal hydrolase 35"
                     /protein_id="NP_065849.1"
                     /db_xref="CCDS:CCDS41693.1"
                     /db_xref="GeneID:57558"
                     /db_xref="HGNC:HGNC:20061"
                     /db_xref="MIM:620959"
                     /translation="MDKILEAVVTSSYPVSVKQGLVRRVLEAARQPLEREQCLALLAL
                     GARLYVGGAEELPRRVGCQLLHVAGRHHPDVFAEFFSARRVLRLLQGGAGPPGPRALA
                     CVQLGLQLLPEGPAADEVFALLRREVLRTVCERPGPAACAQVARLLARHPRCVPDGPH
                     RLLFCQQLVRCLGRFRCPAEGEEGAVEFLEQAQQVSGLLAQLWRAQPAAILPCLKELF
                     AVISCAEEEPPSSALASVVQHLPLELMDGVVRNLSNDDSVTDSQMLTAISRMIDWVSW
                     PLGKNIDKWIIALLKGLAAVKKFSILIEVSLTKIEKVFSKLLYPIVRGAALSVLKYML
                     LTFQHSHEAFHLLLPHIPPMVASLVKEDSNSGTSCLEQLAELVHCMVFRFPGFPDLYE
                     PVMEAIKDLHVPNEDRIKQLLGQDAWTSQKSELAGFYPRLMAKSDTGKIGLINLGNTC
                     YVNSILQALFMASDFRHCVLRLTENNSQPLMTKLQWLFGFLEHSQRPAISPENFLSAS
                     WTPWFSPGTQQDCSEYLKYLLDRLHEEEKTGTRICQKLKQSSSPSPPEEPPAPSSTSV
                     EKMFGGKIVTRICCLCCLNVSSREEAFTDLSLAFPPPERCRRRRLGSVMRPTEDITAR
                     ELPPPTSAQGPGRVGPRRQRKHCITEDTPPTSLYIEGLDSKEAGGQSSQEERIEREEE
                     GKEERTEKEEVGEEEESTRGEGEREKEEEVEEEEEKVEKETEKEAEQEKEEDSLGAGT
                     HPDAAIPSGERTCGSEGSRSVLDLVNYFLSPEKLTAENRYYCESCASLQDAEKVVELS
                     QGPCYLILTLLRFSFDLRTMRRRKILDDVSIPLLLRLPLAGGRGQAYDLCSVVVHSGV
                     SSESGHYYCYAREGAARPAASLGTADRPEPENQWYLFNDTRVSFSSFESVSNVTSFFP
                     KDTAYVLFYRQRPREGPEAELGSSRVRTEPTLHKDLMEAISKDNILYLQEQEKEARSR
                     AAYISALPTSPHWGRGFDEDKDEDEGSPGGCNPAGGNGGDFHRLVF"
     exon            923..1055
                     /gene="USP35"
                     /inference="alignment:Splign:2.1.0"
     exon            1056..1185
                     /gene="USP35"
                     /inference="alignment:Splign:2.1.0"
     exon            1186..1287
                     /gene="USP35"
                     /inference="alignment:Splign:2.1.0"
     exon            1288..1446
                     /gene="USP35"
                     /inference="alignment:Splign:2.1.0"
     exon            1447..1640
                     /gene="USP35"
                     /inference="alignment:Splign:2.1.0"
     exon            1641..1734
                     /gene="USP35"
                     /inference="alignment:Splign:2.1.0"
     exon            1735..1841
                     /gene="USP35"
                     /inference="alignment:Splign:2.1.0"
     exon            1842..3138
                     /gene="USP35"
                     /inference="alignment:Splign:2.1.0"
     exon            3139..4725
                     /gene="USP35"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3503..3508
                     /regulatory_class="polyA_signal_sequence"
                     /gene="USP35"
                     /note="hexamer: ATTAAA"
     polyA_site      3521
                     /gene="USP35"
     regulatory      4182..4187
                     /regulatory_class="polyA_signal_sequence"
                     /gene="USP35"
                     /note="hexamer: AATAAA"
     polyA_site      4188
                     /gene="USP35"
     polyA_site      4202
                     /gene="USP35"
                     /note="major polyA site"
     regulatory      4703..4708
                     /regulatory_class="polyA_signal_sequence"
                     /gene="USP35"
                     /note="hexamer: AATAAA"
     polyA_site      4725
                     /gene="USP35"
ORIGIN      
        1 agccccgggg ccgcgccgca gagtcgggct tcctggatac atagaggctt gtgccaggcg
       61 gggtgggaag actggatttt gcagtggaag cagcatctct tccgtctggg acctggctga
      121 gggcgtcccc accctggggg gagcagagga ccagccctga cctagccggg cccagcctcg
      181 tcctgcccgg cctgagcgcc ccgcccagca gccggctctg gcccaccggg gtccgggagc
      241 gcgggcgcca tggacaagat cttggaggcg gtggtgacgt cgtcataccc ggtcagcgtg
      301 aagcaggggc tggttcggcg cgtgctggag gcggcgcggc agccgctgga gcgtgagcag
      361 tgcctggcgc tgctggcgct gggcgcgcgc ctctacgtgg gcggcgcgga ggagctgccg
      421 cgccgcgtgg gctgccagct gctgcacgtg gccggccgcc accaccccga cgtcttcgcc
      481 gagttcttca gcgcgcgtcg cgtgctgcgc ctgctgcagg gtggcgccgg ccccccgggc
      541 ccccgcgcgc tcgcctgcgt gcagctgggt ctgcagctgc tgcccgaggg gcctgcggcc
      601 gacgaggtgt tcgcgctgct gcggcgcgag gtgctgcgca ccgtgtgcga gcgcccgggc
      661 cccgcggcct gcgcgcaggt ggcacggctg ctggctcgcc acccgcgctg tgtgcccgac
      721 ggaccccacc gcctgctctt ctgccagcag ctggtgcgtt gcctcggccg cttccgctgc
      781 ccagccgaag gcgaggaggg cgccgtggag ttcctagagc aggcccagca ggtgagcggg
      841 ctcctggcgc agctgtggcg cgcacagccc gccgccatcc tgccctgcct caaagagctg
      901 ttcgcagtca tctcctgcgc agaggaggag ccaccatcta gcgccctggc cagcgtggtc
      961 cagcacctcc cattggagct catggatggt gttgtccgga acctcagcaa tgatgacagt
     1021 gtgacagact cgcagatgct gactgccatt agcaggatga ttgactgggt gtcctggccc
     1081 ctggggaaga atattgacaa gtggatcatt gcactgctga agggcctggc tgctgttaag
     1141 aagttcagca tcttgatcga ggtttcgctc accaaaattg agaaggtttt ctctaagctg
     1201 ctgtacccca tcgtccgggg agctgccttg tctgtgctca agtacatgct cctgaccttc
     1261 cagcactccc acgaagcctt ccacctgctc ctccctcaca tcccccccat ggtggcctct
     1321 ctggtcaagg aggactcgaa ctcggggacc agctgcctgg agcagctggc ggagctggtc
     1381 cactgcatgg tgttccggtt cccgggcttc ccggatctgt atgagcctgt catggaggcc
     1441 atcaaggacc tccatgttcc caatgaggac cgcatcaagc agctgctggg gcaggatgcc
     1501 tggacttcgc agaagagcga gctggcgggt ttctatcccc ggctcatggc caagtcagac
     1561 acgggcaaga ttggtctcat caacctgggc aacacatgct atgtcaacag catccttcag
     1621 gccttattca tggcgtctga cttcagacat tgtgtgctcc gcttgactga gaacaactca
     1681 cagcccctga tgaccaagct gcagtggctc tttggcttcc tagaacacag ccagcggcct
     1741 gccatttccc cagagaactt cctctccgca tcctggacgc cctggttcag ccctggcacc
     1801 cagcaggact gctcggagta tctgaagtac ctgctggatc ggctgcacga agaggagaaa
     1861 acgggcacaa ggatctgcca gaaactcaag cagtccagct cgccctctcc gcccgaggag
     1921 cccccggccc caagttcaac ctctgtggaa aaaatgtttg gaggcaagat agtgactcgg
     1981 atctgctgtc tctgctgcct caacgtctcc tcccgggagg aggccttcac ggacctctct
     2041 ctcgccttcc ctcctcctga gcgctgtcgc cgccgccgcc tgggctctgt gatgcgcccc
     2101 acagaagaca tcacagcccg ggagttgccc ccaccaacca gtgcacaggg gccaggcagg
     2161 gtgggtcctc ggaggcaaag gaaacactgc atcacagagg acaccccccc caccagcctg
     2221 tacatcgaag gcctggactc caaggaagct ggtgggcaga gcagtcagga ggaaaggata
     2281 gagagggagg aagaagggaa ggaggagaga acggagaagg aagaagtggg ggaggaggag
     2341 gaaagcacca gaggggaagg agagagggag aaagaggagg aggtggaaga ggaagaagag
     2401 aaggtggaga aggagacaga aaaggaggct gagcaggaaa aggaagaaga cagcctggga
     2461 gcggggaccc acccggatgc tgccatcccc tccggggagc ggacatgtgg ctctgagggc
     2521 tcccgctccg tcctggacct ggttaactac ttcctgtccc ccgagaagct gacagcagaa
     2581 aaccgctact actgcgagtc gtgtgcctcc ctgcaggatg ccgagaaggt ggtggagctg
     2641 agccaagggc cgtgctacct catcctcaca ctgctgcgct tctctttcga cctgcgcacc
     2701 atgcggcgcc gcaagatcct ggatgacgtc tccatccccc tgctgctccg cctgccactg
     2761 gctggtggcc gtggccaggc ctatgacctc tgcagtgtgg tggtgcactc tggagtgtct
     2821 tcggagagtg gtcactacta ctgctatgcc cgtgagggcg ctgcccgccc tgccgcttct
     2881 ctgggaactg ccgataggcc agagcccgag aaccagtggt acctgttcaa tgacactcgg
     2941 gtgtccttct cttccttcga atctgtcagc aacgtcacct ccttcttccc taaggacaca
     3001 gcctatgtgc tgttttaccg gcagcggccc agggaggggc ccgaggctga gttgggctct
     3061 tctagagtcc ggacagagcc caccctgcac aaggacttga tggaagccat ttccaaagac
     3121 aacatccttt acctacagga gcaggagaag gaggcccgga gcagggcggc ctacatctct
     3181 gcactcccca catctccgca ctgggggagg ggctttgatg aagacaagga tgaggatgaa
     3241 ggctctccag ggggctgcaa tcctgcaggt ggcaatggtg gtgacttcca cagactggtc
     3301 ttctaatgtg aacctgctgc caacctgacc ccttccctcc aggagccagg tagggcctga
     3361 gggaagctgt ggaggcaggc cctaccaaga ggaaggatgg tacagctcat ggcaccttag
     3421 tcctcagcct gatgaagggt acacagagat tctctcagat atggaagtaa gacctaagtc
     3481 cctttcattg gggatcagtc ccattaaaac tttacaccca agtgtcctgg ttaacttgaa
     3541 gcagccgaga tgggcacaca cgggtctttg cctccccctc cttccctagc aggctcccca
     3601 tgcgggaaga tctgatgatg ttcaggaaac aggctagacc tcagctccaa tgttttgaca
     3661 tcaagtacta ttttccttcc gactgctgta cggtataaag cacagcagga tccaagcctt
     3721 gcacaaaggg gtgggggggg cagtgtctcc tctggctgtc ctgtttgttt gtttctcata
     3781 tgggggtggg gggtacctgc actgtctgta cctttctgag aagaacagag accgagacct
     3841 gcccccttac caagcgccac tgcatggttt tggggggggg ggcggggggc tagcttctca
     3901 cagcaggagg cctttgcccc cacagcccct ccacgcctgc ctcagggcct gagaagccac
     3961 cacttgtatc ccccttgtgg ttagagtcct gattttactg caaaggtgtt catgttcctt
     4021 gtgaagtgtg ggctcttagg aagcctgtgg gctcctctga gcagttggcc tttgtagctg
     4081 caacagcagc cacctgcagg ttgggtgaag tgccctgaca ctgctgtagc ccccttctaa
     4141 cttctaaccg aagacaagac agacacccat gttcataaat aaataaaagt aagcctaagc
     4201 aagagattgt tcttccttgg actcaggggc tgtgatggcc actgggtttt gctcacgggg
     4261 tctggggagg ccaggactca gcctgccccc cagtgacgtg tgagatgcca cagggagcca
     4321 agagccctct actgaatcta ctgaagtggg gtgtaagtaa acgtgtggac tgactgactt
     4381 acttacctta ctgagggctg ggtgatgctg cccgtggaga ggatgcacct gggaggcagc
     4441 tctcaagcct ttacctacct ccttccccag gggctgcctg ctgtgatggt ggtgtggagt
     4501 ttgggcccaa tgtcacagac cctcaagatg tcacatctaa gtgacctgtg aaagcagcag
     4561 acagacacgc ccagaaccca tctctagacg cctaagaaag ctggatgggt aaatgctagt
     4621 atgatttcca ctttacaaca gacgctgagg tagagagcat ttgttcttat tcacagccaa
     4681 gaaaaatacc caattatttc caaataaagc aaaaattgga acaga
//
