LOCUS       NM_014709              11675 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens ubiquitin specific peptidase 34 (USP34), mRNA.
ACCESSION   NM_014709 XM_291018
VERSION     NM_014709.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 11675)
  AUTHORS   Zhu,Q., Liang,P., Meng,H., Li,F., Miao,W., Chu,C., Wang,W., Li,D.,
            Chen,C., Shi,Y., Yu,X., Ping,Y., Niu,C., Wu,H.B., Zhang,A.,
            Bian,X.W. and Zhou,W.
  TITLE     Stabilization of Pin1 by USP34 promotes Ubc9 isomerization and
            protein sumoylation in glioma stem cells
  JOURNAL   Nat Commun 15 (1), 40 (2024)
   PUBMED   38167292
  REMARK    GeneRIF: Stabilization of Pin1 by USP34 promotes Ubc9 isomerization
            and protein sumoylation in glioma stem cells.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 11675)
  AUTHORS   Cheng,N. and Trejo,J.
  TITLE     An siRNA library screen identifies CYLD and USP34 as
            deubiquitinases that regulate GPCR-p38 MAPK signaling and distinct
            inflammatory responses
  JOURNAL   J Biol Chem 299 (12), 105370 (2023)
   PUBMED   37865315
  REMARK    GeneRIF: An siRNA library screen identifies CYLD and USP34 as
            deubiquitinases that regulate GPCR-p38 MAPK signaling and distinct
            inflammatory responses.
REFERENCE   3  (bases 1 to 11675)
  AUTHORS   Xu,G., Su,H., Lu,L., Liu,X., Zhao,L., Tang,B. and Ming,Z.
  TITLE     Structural Insights into the Catalytic Mechanism and Ubiquitin
            Recognition of USP34
  JOURNAL   J Mol Biol 434 (13), 167634 (2022)
   PUBMED   35588869
  REMARK    GeneRIF: Structural Insights into the Catalytic Mechanism and
            Ubiquitin Recognition of USP34.
REFERENCE   4  (bases 1 to 11675)
  AUTHORS   Dai,W.L., Yuan,S.X. and Cao,J.P.
  TITLE     The deubiquitinase USP34 stabilizes SOX2 and induces cell survival
            and drug resistance in laryngeal squamous cell carcinoma
  JOURNAL   Kaohsiung J Med Sci 36 (12), 983-989 (2020)
   PUBMED   32783291
  REMARK    GeneRIF: The deubiquitinase USP34 stabilizes SOX2 and induces cell
            survival and drug resistance in laryngeal squamous cell carcinoma.
REFERENCE   5  (bases 1 to 11675)
  AUTHORS   Wang,H., Ju,D., Kho,D.H., Yang,H., Li,L., Raz,A., Sun,F. and Xie,Y.
  TITLE     The ubiquitin specific protease USP34 protects the ubiquitin ligase
            gp78 from proteasomal degradation
  JOURNAL   Biochem Biophys Res Commun 509 (2), 348-353 (2019)
   PUBMED   30585151
  REMARK    GeneRIF: The study unveils a previously unknown function of USP34
            in regulating the metabolic stability of gp78.
REFERENCE   6  (bases 1 to 11675)
  AUTHORS   Kenny,E.E., Pe'er,I., Karban,A., Ozelius,L., Mitchell,A.A.,
            Ng,S.M., Erazo,M., Ostrer,H., Abraham,C., Abreu,M.T., Atzmon,G.,
            Barzilai,N., Brant,S.R., Bressman,S., Burns,E.R., Chowers,Y.,
            Clark,L.N., Darvasi,A., Doheny,D., Duerr,R.H., Eliakim,R.,
            Giladi,N., Gregersen,P.K., Hakonarson,H., Jones,M.R., Marder,K.,
            McGovern,D.P., Mulle,J., Orr-Urtreger,A., Proctor,D.D., Pulver,A.,
            Rotter,J.I., Silverberg,M.S., Ullman,T., Warren,S.T., Waterman,M.,
            Zhang,W., Bergman,A., Mayer,L., Katz,S., Desnick,R.J., Cho,J.H. and
            Peter,I.
  TITLE     A genome-wide scan of Ashkenazi Jewish Crohn's disease suggests
            novel susceptibility loci
  JOURNAL   PLoS Genet 8 (3), e1002559 (2012)
   PUBMED   22412388
REFERENCE   7  (bases 1 to 11675)
  AUTHORS   Lui,T.T., Lacroix,C., Ahmed,S.M., Goldenberg,S.J., Leach,C.A.,
            Daulat,A.M. and Angers,S.
  TITLE     The ubiquitin-specific protease USP34 regulates axin stability and
            Wnt/beta-catenin signaling
  JOURNAL   Mol Cell Biol 31 (10), 2053-2065 (2011)
   PUBMED   21383061
  REMARK    GeneRIF: axin associates with ubiquitin-specific protease 34
            (USP34); results indicate USP34 controls the levels of axin and
            positively modulate Wnt signaling by acting downstream of
            beta-catenin stabilization through controlling the nuclear
            accumulation of axin
REFERENCE   8  (bases 1 to 11675)
  AUTHORS   Ballif,B.A., Villen,J., Beausoleil,S.A., Schwartz,D. and Gygi,S.P.
  TITLE     Phosphoproteomic analysis of the developing mouse brain
  JOURNAL   Mol Cell Proteomics 3 (11), 1093-1101 (2004)
   PUBMED   15345747
REFERENCE   9  (bases 1 to 11675)
  AUTHORS   Quesada,V., Diaz-Perales,A., Gutierrez-Fernandez,A., Garabaya,C.,
            Cal,S. and Lopez-Otin,C.
  TITLE     Cloning and enzymatic analysis of 22 novel human ubiquitin-specific
            proteases
  JOURNAL   Biochem Biophys Res Commun 314 (1), 54-62 (2004)
   PUBMED   14715245
REFERENCE   10 (bases 1 to 11675)
  AUTHORS   Puente,X.S., Sanchez,L.M., Overall,C.M. and Lopez-Otin,C.
  TITLE     Human and mouse proteases: a comparative genomic approach
  JOURNAL   Nat Rev Genet 4 (7), 544-558 (2003)
   PUBMED   12838346
  REMARK    Review article
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC016727.10, AB011142.2, BX473680.1, AC016894.11, AC018889.7,
            AK023171.1 and AW293998.1.
            
            On May 17, 2019 this sequence version replaced NM_014709.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMEA1965299, SAMEA1966682
                              [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000398571.7/ ENSP00000381577.2
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-373               AC016727.10        37727-38099         c
            374-505             AB011142.2         55-186
            506-1017            BX473680.1         139-650
            1018-2376           AB011142.2         700-2058
            2377-2378           AC016894.11        50144-50145         c
            2379-4816           AB011142.2         2061-4498
            4817-4818           AC018889.7         89043-89044         c
            4819-11587          AB011142.2         4501-11269
            11588-11674         AK023171.1         2492-2578
            11675-11675         AW293998.1         25-25               c
FEATURES             Location/Qualifiers
     source          1..11675
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2p15"
     gene            1..11675
                     /gene="USP34"
                     /note="ubiquitin specific peptidase 34"
                     /db_xref="GeneID:9736"
                     /db_xref="HGNC:HGNC:20066"
                     /db_xref="MIM:615295"
     exon            1..438
                     /gene="USP34"
                     /inference="alignment:Splign:2.1.0"
     CDS             396..11036
                     /gene="USP34"
                     /EC_number="3.4.19.12"
                     /note="ubiquitin specific protease 34; ubiquitin
                     thioesterase 34; deubiquitinating enzyme 34;
                     ubiquitin-specific-processing protease 34; ubiquitin
                     thiolesterase 34"
                     /codon_start=1
                     /product="ubiquitin carboxyl-terminal hydrolase 34"
                     /protein_id="NP_055524.3"
                     /db_xref="CCDS:CCDS42686.1"
                     /db_xref="GeneID:9736"
                     /db_xref="HGNC:HGNC:20066"
                     /db_xref="MIM:615295"
                     /translation="MCENCADLVEVLNEISDVEGGDGLQLRKEHTLKIFTYINSWTQR
                     QCLCCFKEYKHLEIFNQVVCALINLVIAQVQVLRDQLCKHCTTINIDSTWQDESNQAE
                     EPLNIDRECNEGSTERQKSIEKKSNSTRICNLTEEESSKSSDPFSLWSTDEKEKLLLC
                     VAKIFQIQFPLYTAYKHNTHPTIEDISTQESNILGAFCDMNDVEVPLHLLRYVCLFCG
                     KNGLSLMKDCFEYGTPETLPFLIAHAFITVVSNIRIWLHIPAVMQHIIPFRTYVIRYL
                     CKLSDQELRQSAARNMADLMWSTVKEPLDTTLCFDKESLDLAFKYFMSPTLTMRLAGL
                     SQITNQLHTFNDVCNNESLVSDTETSIAKELADWLISNNVVEHIFGPNLHIEIIKQCQ
                     VILNFLAAEGRLSTQHIDCIWAAAQLKHCSRYIHDLFPSLIKNLDPVPLRHLLNLVSA
                     LEPSVHTEQTLYLASMLIKALWNNALAAKAQLSKQSSFASLLNTNIPIGNKKEEEELR
                     RTAPSPWSPAASPQSSDNSDTHQSGGSDIEMDEQLINRTKHVQQRLSDTEESMQGSSD
                     ETANSGEDGSSGPGSSSGHSDGSSNEVNSSHASQSAGSPGSEVQSEDIADIEALKEED
                     EDDDHGHNPPKSSCGTDLRNRKLESQAGICLGDSQGMSERNGTSSGTGKDLVFNTESL
                     PSVDNRMRMLDACSHSEDPEHDISGEMNATHIAQGSQESCITRTGDFLGETIGNELFN
                     CRQFIGPQHHHHHHHHHHHHDGHMVDDMLSADDVSCSSSQVSAKSEKNMADFDGEESG
                     CEEELVQINSHAELTSHLQQHLPNLASIYHEHLSQGPVVHKHQFNSNAVTDINLDNVC
                     KKGNTLLWDIVQDEDAVNLSEGLINEAEKLLCSLVCWFTDRQIRMRFIEGCLENLGNN
                     RSVVISLRLLPKLFGTFQQFGSSYDTHWITMWAEKELNMMKLFFDNLVYYIQTVREGR
                     QKHALYSHSAEVQVRLQFLTCVFSTLGSPDHFRLSLEQVDILWHCLVEDSECYDDALH
                     WFLNQVRSKDQHAMGMETYKHLFLEKMPQLKPETISMTGLNLFQHLCNLARLATSAYD
                     GCSNSELCGMDQFWGIALRAQSGDVSRAAIQYINSYYINGKTGLEKEQEFISKCMESL
                     MIASSSLEQESHSSLMVIERGLLMLKTHLEAFRRRFAYHLRQWQIEGTGISSHLKALS
                     DKQSLPLRVVCQPAGLPDKMTIEMYPSDQVADLRAEVTHWYENLQKEQINQQAQLQEF
                     GQSNRKGEFPGGLMGPVRMISSGHELTTDYDEKALHELGFKDMQMVFVSLGAPRRERK
                     GEGVQLPASCLPPPQKDNIPMLLLLQEPHLTTLFDLLEMLASFKPPSGKVAVDDSESL
                     RCEELHLHAENLSRRVWELLMLLPTCPNMLMAFQNISDEQSNDGFNWKELLKIKSAHK
                     LLYALEIIEALGKPNRRIRRESTGSYSDLYPDSDDSSEDQVENSKNSWSCKFVAAGGL
                     QQLLEIFNSGILEPKEQESWTVWQLDCLACLLKLICQFAVDPSDLDLAYHDVFAWSGI
                     AESHRKRTWPGKSRKAAGDHAKGLHIPRLTEVFLVLVQGTSLIQRLMSVAYTYDNLAP
                     RVLKAQSDHRSRHEVSHYSMWLLVSWAHCCSLVKSSLADSDHLQDWLKKLTLLIPETA
                     VRHESCSGLYKLSLSGLDGGDSINRSFLLLAASTLLKFLPDAQALKPIRIDDYEEEPI
                     LKPGCKEYFWLLCKLVDNIHIKDASQTTLLDLDALARHLADCIRSREILDHQDGNVED
                     DGLTGLLRLATSVVKHKPPFKFSREGQEFLRDIFNLLFLLPSLKDRQQPKCKSHSSRA
                     AAYDLLVEMVKGSVENYRLIHNWVMAQHMQSHAPYKWDYWPHEDVRAECRFVGLTNLG
                     ATCYLASTIQQLYMIPEARQAVFTAKYSEDMKHKTTLLELQKMFTYLMESECKAYNPR
                     PFCKTYTMDKQPLNTGEQKDMTEFFTDLITKIEEMSPELKNTVKSLFGGVITNNVVSL
                     DCEHVSQTAEEFYTVRCQVADMKNIYESLDEVTIKDTLEGDNMYTCSHCGKKVRAEKR
                     ACFKKLPRILSFNTMRYTFNMVTMMKEKVNTHFSFPLRLDMTPYTEDFLMGKSERKEG
                     FKEVSDHSKDSESYEYDLIGVTVHTGTADGGHYYSFIRDIVNPHAYKNNKWYLFNDAE
                     VKPFDSAQLASECFGGEMTTKTYDSVTDKFMDFSFEKTHSAYMLFYKRMEPEEENGRE
                     YKFDVSSELLEWIWHDNMQFLQDKNIFEHTYFGFMWQLCSCIPSTLPDPKAVSLMTAK
                     LSTSFVLETFIHSKEKPTMLQWIELLTKQFNNSQAACEWFLDRMADDDWWPMQILIKC
                     PNQIVRQMFQRLCIHVIQRLRPVHAHLYLQPGMEDGSDDMDTSVEDIGGRSCVTRFVR
                     TLLLIMEHGVKPHSKHLTEYFAFLYEFAKMGEEESQFLLSLQAISTMVHFYMGTKGPE
                     NPQVEVLSEEEGEEEEEEEDILSLAEEKYRPAALEKMIALVALLVEQSRSERHLTLSQ
                     TDMAALTGGKGFPFLFQHIRDGINIRQTCNLIFSLCRYNNRLAEHIVSMLFTSIAKLT
                     PEAANPFFKLLTMLMEFAGGPPGMPPFASYILQRIWEVIEYNPSQCLDWLAVQTPRNK
                     LAHSWVLQNMENWVERFLLAHNYPRVRTSAAYLLVSLIPSNSFRQMFRSTRSLHIPTR
                     DLPLSPDTTVVLHQVYNVLLGLLSRAKLYVDAAVHGTTKLVPYFSFMTYCLISKTEKL
                     MFSTYFMDLWNLFQPKLSEPAIATNHNKQALLSFWYNVCADCPENIRLIVQNPVVTKN
                     IAFNYILADHDDQDVVLFNRGMLPAYYGILRLCCEQSPAFTRQLASHQNIQWAFKNLT
                     PHASQYPGAVEELFNLMQLFIAQRPDMREEELEDIKQFKKTTISCYLRCLDGRSCWTT
                     LISAFRILLESDEDRLLVVFNRGLILMTESFNTLHMMYHEATACHVTGDLVELLSIFL
                     SVLKSTRPYLQRKDVKQALIQWQERIEFAHKLLTLLNSYSPPELRNACIDVLKELVLL
                     SPHDFLHTLVPFLQHNHCTYHHSNIPMSLGPYFPCRENIKLIGGKSNIRPPRPELNMC
                     LLPTMVETSKGKDDVYDRMLLDYFFSYHQFIHLLCRVAINCEKFTETLVKLSVLVAYE
                     GLPLHLALFPKLWTELCQTQSAMSKNCIKLLCEDPVFAEYIKCILMDERTFLNNNIVY
                     TFMTHFLLKVQSQVFSEANCANLISTLITNLISQYQNLQSDFSNRVEISKASASLNGD
                     LRALALLLSVHTPKQLNPALIPTLQELLSKCRTCLQQRNSLQEQEAKERKTKDDEGAT
                     PIKRRRVSSDEEHTVDSCISDMKTETREVLTPTSTSDNETRDSSIIDPGTEQDLPSPE
                     NSSVKEYRMEVPSSFSEDMSNIRSQHAEEQSNNGRYDDCKEFKDLHCSKDSTLAEEES
                     EFPSTSISAVLSDLADLRSCDGQALPSQDPEVALSLSCGHSRGLFSHMQQHDILDTLC
                     RTIESTIHVVTRISGKGNQAAS"
     exon            439..526
                     /gene="USP34"
                     /inference="alignment:Splign:2.1.0"
     exon            527..947
                     /gene="USP34"
                     /inference="alignment:Splign:2.1.0"
     exon            948..998
                     /gene="USP34"
                     /inference="alignment:Splign:2.1.0"
     exon            999..1148
                     /gene="USP34"
                     /inference="alignment:Splign:2.1.0"
     exon            1149..1216
                     /gene="USP34"
                     /inference="alignment:Splign:2.1.0"
     exon            1217..1409
                     /gene="USP34"
                     /inference="alignment:Splign:2.1.0"
     exon            1410..1471
                     /gene="USP34"
                     /inference="alignment:Splign:2.1.0"
     exon            1472..1553
                     /gene="USP34"
                     /inference="alignment:Splign:2.1.0"
     exon            1554..1646
                     /gene="USP34"
                     /inference="alignment:Splign:2.1.0"
     exon            1647..1772
                     /gene="USP34"
                     /inference="alignment:Splign:2.1.0"
     exon            1773..1902
                     /gene="USP34"
                     /inference="alignment:Splign:2.1.0"
     exon            1903..1938
                     /gene="USP34"
                     /inference="alignment:Splign:2.1.0"
     exon            1939..2069
                     /gene="USP34"
                     /inference="alignment:Splign:2.1.0"
     exon            2070..2680
                     /gene="USP34"
                     /inference="alignment:Splign:2.1.0"
     exon            2681..2895
                     /gene="USP34"
                     /inference="alignment:Splign:2.1.0"
     exon            2896..3011
                     /gene="USP34"
                     /inference="alignment:Splign:2.1.0"
     exon            3012..3139
                     /gene="USP34"
                     /inference="alignment:Splign:2.1.0"
     exon            3140..3229
                     /gene="USP34"
                     /inference="alignment:Splign:2.1.0"
     exon            3230..3325
                     /gene="USP34"
                     /inference="alignment:Splign:2.1.0"
     exon            3326..3408
                     /gene="USP34"
                     /inference="alignment:Splign:2.1.0"
     exon            3409..3563
                     /gene="USP34"
                     /inference="alignment:Splign:2.1.0"
     exon            3564..3677
                     /gene="USP34"
                     /inference="alignment:Splign:2.1.0"
     exon            3678..3777
                     /gene="USP34"
                     /inference="alignment:Splign:2.1.0"
     exon            3778..3937
                     /gene="USP34"
                     /inference="alignment:Splign:2.1.0"
     exon            3938..4064
                     /gene="USP34"
                     /inference="alignment:Splign:2.1.0"
     exon            4065..4212
                     /gene="USP34"
                     /inference="alignment:Splign:2.1.0"
     exon            4213..4313
                     /gene="USP34"
                     /inference="alignment:Splign:2.1.0"
     exon            4314..4523
                     /gene="USP34"
                     /inference="alignment:Splign:2.1.0"
     exon            4524..4649
                     /gene="USP34"
                     /inference="alignment:Splign:2.1.0"
     exon            4650..4772
                     /gene="USP34"
                     /inference="alignment:Splign:2.1.0"
     exon            4773..4856
                     /gene="USP34"
                     /inference="alignment:Splign:2.1.0"
     exon            4857..4943
                     /gene="USP34"
                     /inference="alignment:Splign:2.1.0"
     exon            4944..5144
                     /gene="USP34"
                     /inference="alignment:Splign:2.1.0"
     exon            5145..5227
                     /gene="USP34"
                     /inference="alignment:Splign:2.1.0"
     exon            5228..5268
                     /gene="USP34"
                     /inference="alignment:Splign:2.1.0"
     exon            5269..5393
                     /gene="USP34"
                     /inference="alignment:Splign:2.1.0"
     exon            5394..5546
                     /gene="USP34"
                     /inference="alignment:Splign:2.1.0"
     exon            5547..5651
                     /gene="USP34"
                     /inference="alignment:Splign:2.1.0"
     exon            5652..5707
                     /gene="USP34"
                     /inference="alignment:Splign:2.1.0"
     exon            5708..5828
                     /gene="USP34"
                     /inference="alignment:Splign:2.1.0"
     exon            5829..6012
                     /gene="USP34"
                     /inference="alignment:Splign:2.1.0"
     exon            6013..6173
                     /gene="USP34"
                     /inference="alignment:Splign:2.1.0"
     exon            6174..6239
                     /gene="USP34"
                     /inference="alignment:Splign:2.1.0"
     exon            6240..6386
                     /gene="USP34"
                     /inference="alignment:Splign:2.1.0"
     exon            6387..6443
                     /gene="USP34"
                     /inference="alignment:Splign:2.1.0"
     exon            6444..6521
                     /gene="USP34"
                     /inference="alignment:Splign:2.1.0"
     exon            6522..6616
                     /gene="USP34"
                     /inference="alignment:Splign:2.1.0"
     exon            6617..6789
                     /gene="USP34"
                     /inference="alignment:Splign:2.1.0"
     exon            6790..6943
                     /gene="USP34"
                     /inference="alignment:Splign:2.1.0"
     exon            6944..7022
                     /gene="USP34"
                     /inference="alignment:Splign:2.1.0"
     exon            7023..7076
                     /gene="USP34"
                     /inference="alignment:Splign:2.1.0"
     exon            7077..7172
                     /gene="USP34"
                     /inference="alignment:Splign:2.1.0"
     exon            7173..7237
                     /gene="USP34"
                     /inference="alignment:Splign:2.1.0"
     exon            7238..7313
                     /gene="USP34"
                     /inference="alignment:Splign:2.1.0"
     exon            7314..7361
                     /gene="USP34"
                     /inference="alignment:Splign:2.1.0"
     exon            7362..7427
                     /gene="USP34"
                     /inference="alignment:Splign:2.1.0"
     exon            7428..7508
                     /gene="USP34"
                     /inference="alignment:Splign:2.1.0"
     exon            7509..7594
                     /gene="USP34"
                     /inference="alignment:Splign:2.1.0"
     exon            7595..7763
                     /gene="USP34"
                     /inference="alignment:Splign:2.1.0"
     exon            7764..7838
                     /gene="USP34"
                     /inference="alignment:Splign:2.1.0"
     exon            7839..7990
                     /gene="USP34"
                     /inference="alignment:Splign:2.1.0"
     exon            7991..8039
                     /gene="USP34"
                     /inference="alignment:Splign:2.1.0"
     exon            8040..8144
                     /gene="USP34"
                     /inference="alignment:Splign:2.1.0"
     exon            8145..8189
                     /gene="USP34"
                     /inference="alignment:Splign:2.1.0"
     exon            8190..8294
                     /gene="USP34"
                     /inference="alignment:Splign:2.1.0"
     exon            8295..8442
                     /gene="USP34"
                     /inference="alignment:Splign:2.1.0"
     exon            8443..9077
                     /gene="USP34"
                     /inference="alignment:Splign:2.1.0"
     exon            9078..9235
                     /gene="USP34"
                     /inference="alignment:Splign:2.1.0"
     exon            9236..9314
                     /gene="USP34"
                     /inference="alignment:Splign:2.1.0"
     exon            9315..9441
                     /gene="USP34"
                     /inference="alignment:Splign:2.1.0"
     exon            9442..9549
                     /gene="USP34"
                     /inference="alignment:Splign:2.1.0"
     exon            9550..9654
                     /gene="USP34"
                     /inference="alignment:Splign:2.1.0"
     exon            9655..9779
                     /gene="USP34"
                     /inference="alignment:Splign:2.1.0"
     exon            9780..9903
                     /gene="USP34"
                     /inference="alignment:Splign:2.1.0"
     exon            9904..9983
                     /gene="USP34"
                     /inference="alignment:Splign:2.1.0"
     exon            9984..10124
                     /gene="USP34"
                     /inference="alignment:Splign:2.1.0"
     exon            10125..10268
                     /gene="USP34"
                     /inference="alignment:Splign:2.1.0"
     exon            10269..10428
                     /gene="USP34"
                     /inference="alignment:Splign:2.1.0"
     exon            10429..11675
                     /gene="USP34"
                     /inference="alignment:Splign:2.1.0"
     regulatory      11569..11574
                     /regulatory_class="polyA_signal_sequence"
                     /gene="USP34"
                     /note="hexamer: AATAAA"
     polyA_site      11592
                     /gene="USP34"
                     /note="major polyA site"
     regulatory      11650..11655
                     /regulatory_class="polyA_signal_sequence"
                     /gene="USP34"
                     /note="hexamer: ATTAAA"
     polyA_site      11675
                     /gene="USP34"
ORIGIN      
        1 gcagcccgag cgctctgtta aaatggcggc ggcgtcggcg gtggccgcgg cgtctggtcg
       61 gtgaagtgac tctgctgctt ctctccccac ccgccccctc cccccctctc ccctcccccc
      121 gtccttcccc cccttccccg ccgccggcgc ctcggcgccc ctccggcctg cgcacctccc
      181 ctcgctcccc tcctctcccc ctcccgctgc ggggaccgcc ggccccctcc cccattctct
      241 tgctccccgc cccgtccccg ccgccgcccg ccctagtcgc ctccccgccc cgccggccgg
      301 ccggccccct cctccgcctc tctcccctcc cccccgccgg tcgggatcag tcagtgtgat
      361 ccgaagcggg ggaggggggg ggcggcggcc gaacgatgtg cgagaactgc gcagacctgg
      421 tggaggtgtt aaatgaaata tcagatgtag aaggtggtga tggactgcag ctcagaaagg
      481 aacatactct caaaatattt acttatatca attcctggac acagaggcaa tgtctatgct
      541 gcttcaagga atataagcat ttggagattt ttaatcaagt agtgtgtgca cttattaact
      601 tagtgattgc ccaagttcaa gtgctccggg accagctttg taaacattgt actaccatta
      661 acatagattc cacgtggcaa gatgagagta atcaagcaga agaaccactg aatatagata
      721 gagagtgtaa tgaaggaagt acagaaagac aaaaatcaat agaaaaaaaa tcaaactcta
      781 caagaatttg taatctgact gaggaggaat cttcaaagag ttctgatcct tttagtttat
      841 ggagtacaga tgagaaggaa aaactcttac tatgtgtggc aaaaattttt caaattcagt
      901 ttcccttata tactgcttac aagcataata ctcaccctac tattgaggat atatcaactc
      961 aagaaagtaa catattaggg gcattctgtg atatgaatga tgtagaagta ccattgcatt
     1021 tgcttcgtta tgtatgtttg ttttgtggga aaaatggcct ttctctcatg aaggattgct
     1081 ttgaatatgg aactcctgaa actttgccat ttcttatagc acatgcgttt attacagttg
     1141 tgtctaatat tagaatatgg ctacatattc ccgctgtcat gcagcacatt atacctttta
     1201 ggacctatgt tattaggtat ttatgcaagc tctcggatca ggagttacga cagagtgcag
     1261 ctcgtaacat ggctgactta atgtggagca cagtcaaaga accattggat acaacattat
     1321 gctttgataa agaaagccta gatcttgcat ttaagtactt tatgtcacct actttgacta
     1381 tgaggttggc tggattgagt cagataacaa atcaactcca taccttcaat gatgtgtgca
     1441 ataatgaatc attagtatcg gacacagaaa cgtccattgc aaaagaactt gcagactggc
     1501 ttattagcaa caatgtggtg gagcatatat ttggaccaaa tttacatatt gagattatca
     1561 aacagtgcca agtgattttg aattttttgg cagcagaagg gcgactgagt actcaacata
     1621 ttgactgtat ttgggctgca gcacagttga aacattgtag tcggtatata catgacttat
     1681 ttccttcact catcaagaat ttggatcccg taccacttag acatctactt aatctggtct
     1741 cagctcttga gccaagtgtt catactgaac agacactgta cttggcatcc atgttaatta
     1801 aagcactgtg gaataacgca ctagcagcta aggctcagtt atctaaacag agttcttttg
     1861 catctttatt aaatactaat attcccattg gaaataagaa agaggaagaa gagcttagaa
     1921 gaacagctcc atcaccttgg tcacctgcag ctagtcctca aagcagtgat aatagcgata
     1981 cacatcaaag tggaggtagt gacattgaaa tggatgagca acttattaat agaaccaaac
     2041 atgtgcaaca acgactttca gacacagagg aatccatgca gggaagttct gacgaaactg
     2101 ccaacagtgg tgaagatgga agcagtggtc ctggtagcag tagtgggcat agtgatggat
     2161 ctagcaatga ggttaattct agccacgcaa gccagtcagc tgggagccct ggcagtgagg
     2221 tacagtcaga agacattgca gatattgaag ccctcaaaga ggaagatgaa gacgatgatc
     2281 atggtcataa tcctcccaaa agcagttgtg gtacagatct tcggaataga aagttagaga
     2341 gtcaagcagg catttgcctg ggggactccc aaggcatgtc agaaagaaat gggacaagca
     2401 gcggaacagg aaaggacctg gtttttaaca ctgaatcatt gccatcagta gataatcgaa
     2461 tgcgaatgct ggatgcttgt tcacactctg aagacccaga acatgatatt tcaggggaaa
     2521 tgaatgctac tcatatagca caagggtctc aggagtcttg tatcacacga actggggact
     2581 tccttgggga gactattggg aatgaattat ttaattgtcg acaatttatt ggtccacagc
     2641 atcaccacca ccaccaccac catcaccacc accacgatgg gcatatggtt gatgatatgc
     2701 taagtgcaga tgatgtcagt tgtagtagct cccaggttag tgcaaaatca gaaaaaaata
     2761 tggctgattt tgatggtgaa gaatctggat gtgaagagga gctagttcag attaattcac
     2821 atgcggaact gacatctcac ctccaacaac atcttcccaa tttagcttcc atttaccatg
     2881 aacatcttag tcaaggacct gtagttcata aacatcaatt caacagtaat gctgttacag
     2941 acattaattt ggataatgtt tgcaagaaag gaaatacttt gttgtgggat atagtccaag
     3001 atgaagatgc agttaatctt tctgaaggat taataaatga agcagagaaa cttctttgtt
     3061 cgttagtatg ttggtttaca gatagacaaa ttcgaatgag attcattgaa ggttgccttg
     3121 aaaacttggg aaacaacaga tcagtagtaa tttcacttcg tcttcttcca aaactatttg
     3181 gtacttttca gcagtttggg agcagttacg atacacactg gataacaatg tgggcagaaa
     3241 aagaactgaa catgatgaag cttttctttg ataatttggt atactacatt caaactgtga
     3301 gagaaggaag acaaaaacat gcactgtaca gccatagtgc tgaagttcaa gttcgtcttc
     3361 aattcttgac ttgtgtattt tcaactctgg gatcacctga tcatttcagg ttaagtttag
     3421 agcaagttga catcttatgg cattgtttag tagaagattc tgaatgttat gatgatgcac
     3481 tccattggtt tttaaatcaa gttcgaagta aagatcaaca tgctatgggt atggaaacct
     3541 acaaacatct tttcctggag aagatgcccc agctaaaacc tgaaacaatt agcatgactg
     3601 gcttaaacct gtttcagcat ctctgtaact tggctcgatt ggctaccagt gcctatgatg
     3661 gttgttcaaa ttctgagctg tgtggtatgg accaattttg gggcattgct ttaagagcac
     3721 aatctggtga tgtcagtcga gcagctatcc agtatattaa ctcctattat attaatggta
     3781 aaacaggttt ggagaaggag caagaattta ttagtaagtg catggagagt cttatgatag
     3841 cttctagcag tcttgaacag gaatcacact caagtctcat ggttatagaa agaggactcc
     3901 ttatgctgaa gacacatctg gaagcgttta ggagaaggtt tgcatatcat ctgagacagt
     3961 ggcaaattga aggcactggt attagtagtc atttgaaagc actgagtgac aaacagtctc
     4021 tgccgctaag ggttgtatgc cagccagctg gacttcctga caagatgact attgaaatgt
     4081 atcctagtga ccaggtagca gatcttaggg ctgaagtaac tcattggtat gaaaatttac
     4141 agaaagaaca aataaatcaa caagctcagc ttcaggagtt tggtcaaagc aaccgaaaag
     4201 gagagtttcc tggaggcctc atgggacctg tcaggatgat ttcatctgga cacgagttaa
     4261 caacagatta tgatgaaaaa gcacttcatg agcttggttt taaggatatg cagatggtat
     4321 ttgtatcttt gggtgcacca aggagagagc ggaaagggga aggtgttcag ctgccagcat
     4381 cttgcctccc accccctcag aaggacaaca ttccaatgct tttgctttta caagagcctc
     4441 atttaactac tctttttgat ttattagaga tgcttgcatc atttaaacca ccctcaggaa
     4501 aagtggcagt ggatgatagt gagagcttac gatgtgaaga acttcatctt catgcagaaa
     4561 atctgtctag gcgggtctgg gagctactga tgcttcttcc tacatgtcct aatatgttga
     4621 tggcattcca gaatatctca gatgagcaga gtaatgatgg atttaattgg aaagaacttc
     4681 tcaaaattaa gagcgcccac aagctattgt atgctctgga aattattgaa gcactgggaa
     4741 aacctaatag aagaataagg agggagtcta cgggaagtta cagtgatctt tatccagatt
     4801 cagatgattc aagtgaagat caagtggaaa atagtaaaaa ttcctggagt tgcaagtttg
     4861 ttgctgctgg agggcttcaa cagttattag aaatttttaa ttctggaatt ctagagccta
     4921 aagagcagga atcatggact gtgtggcagc tagactgtct tgcttgcttg ctgaagttaa
     4981 tatgccagtt tgcagtagat ccatccgatt tggatttagc ttatcatgat gtctttgcct
     5041 ggtctggtat agcggaaagc cataggaaaa gaacctggcc tggcaaatca aggaaggctg
     5101 ctggtgatca tgctaagggt cttcatatac cacgattaac agaggtattt cttgttcttg
     5161 tccaaggaac cagtttgatt cagcgactta tgtctgttgc ttatacgtat gataatctgg
     5221 ctcctagagt tttaaaagct cagtctgatc acaggtctag acatgaagtt tcacattatt
     5281 caatgtggct cttggtgagt tgggctcatt gctgttcttt agtgaaatct agccttgctg
     5341 atagcgatca tttacaagat tggctaaaga aattgactct ccttattcct gagactgcag
     5401 ttcgtcatga atcatgcagt ggtctctata agttatccct gtcagggctg gatggaggag
     5461 actcaatcaa tcgttctttt ctgctattgg ctgcctcaac attattgaaa tttcttcctg
     5521 atgctcaagc actcaaacct attaggatag atgattatga ggaagaacca atattaaaac
     5581 caggatgtaa agagtatttt tggttgttat gcaaattagt tgacaacata catataaagg
     5641 acgctagtca gacaacgctc ctcgacttag atgccttggc aagacatttg gctgactgta
     5701 ttcgaagtag ggagatcctt gatcatcagg atggtaatgt agaagatgat gggcttacag
     5761 gactcctaag gcttgcaaca agtgttgtta aacacaaacc accctttaaa ttttcaaggg
     5821 aaggacagga atttttgaga gatatcttca atctcctgtt tttgttgcca agtctaaagg
     5881 accgacaaca gccaaagtgc aaatcacatt cttcaagagc tgccgcttac gatttgttag
     5941 tagagatggt aaaggggtct gttgagaact acaggctaat acacaactgg gttatggcac
     6001 aacacatgca gtcccatgca ccttataaat gggattactg gcctcatgaa gatgtccgtg
     6061 ctgaatgtag atttgttggc cttactaacc ttggagctac ttgttactta gcttctacta
     6121 ttcagcaact ttatatgata cctgaggcaa gacaggctgt cttcactgcc aagtattcag
     6181 aggatatgaa gcacaagacc actcttctgg agcttcagaa aatgtttaca tatttaatgg
     6241 agagtgaatg caaagcatat aatcctagac ctttctgtaa aacatacacc atggataagc
     6301 agcctctgaa tactggggaa cagaaagata tgacagagtt ttttactgat ctaattacca
     6361 aaatcgaaga aatgtctccc gaactgaaaa ataccgtcaa aagtttattt ggaggtgtaa
     6421 ttacaaacaa tgttgtatcc ttggattgtg aacatgttag tcaaactgct gaagagtttt
     6481 atactgtgag gtgccaagtg gctgatatga agaacattta tgaatctctt gatgaagtta
     6541 ctataaaaga cactttggaa ggtgataaca tgtatacttg ttctcattgt gggaagaaag
     6601 tacgagctga aaaaagggca tgttttaaga aattgcctcg cattttgagt ttcaatacta
     6661 tgagatacac atttaatatg gtcacgatga tgaaagagaa agtgaataca cacttttcct
     6721 tcccattacg tttggacatg acgccctata cagaagattt tcttatggga aagagtgaga
     6781 ggaaagaagg ttttaaagaa gtcagtgatc attcaaaaga ctcagagagc tatgaatatg
     6841 acttgatagg agtgactgtt cacacaggaa cggcagatgg tggacactat tatagcttta
     6901 tcagagatat agtaaatccc catgcttata aaaacaataa atggtatctt tttaatgatg
     6961 ctgaggtaaa accttttgat tctgctcaac ttgcatctga atgttttggt ggagagatga
     7021 cgaccaagac ctatgattct gttacagata aatttatgga cttctctttt gaaaagacac
     7081 acagtgcata tatgctgttt tacaaacgca tggaaccaga ggaagaaaat ggcagagaat
     7141 acaaatttga tgtttcgtca gagttactag agtggatttg gcatgataac atgcagtttc
     7201 ttcaagacaa aaacattttt gaacatacat attttggatt tatgtggcaa ttgtgtagtt
     7261 gtattcccag tacattacca gatcctaaag ctgtgtcctt aatgacagca aagttaagca
     7321 cttcctttgt cctagagaca tttattcatt ctaaagaaaa gcccacgatg cttcagtgga
     7381 ttgaactgtt gacgaaacag tttaataata gtcaggcagc ttgtgagtgg tttttagatc
     7441 gtatggctga tgacgactgg tggccaatgc agatactaat taagtgccct aatcaaattg
     7501 tgagacagat gtttcagcgt ttgtgtatcc atgtgattca gaggctgaga cctgtgcatg
     7561 ctcatctcta tttgcagcca ggaatggaag atgggtcaga tgatatggat acctcagtag
     7621 aagatattgg tggtcgttca tgtgtcactc gctttgtgag aaccctgtta ttaattatgg
     7681 aacatggtgt aaaacctcac agtaaacatc ttacagagta ttttgccttc ctttacgaat
     7741 ttgcaaaaat gggtgaagaa gagagccaat ttttgctttc attgcaagct atatctacaa
     7801 tggtacattt ttacatggga acaaaaggac ctgaaaatcc tcaagttgaa gtgttatcag
     7861 aggaagaagg ggaagaagaa gaggaggaag aagatatcct ctctctggca gaagaaaaat
     7921 acaggccagc tgcccttgaa aagatgatag ctttagttgc tcttttggtt gaacagtctc
     7981 gatcagaaag gcatttgaca ttatcacaga ctgacatggc agcattaaca ggaggaaagg
     8041 gatttccctt cttgtttcaa catattcgtg atggcatcaa tataagacaa acttgtaatc
     8101 tgattttcag cctgtgtcga tacaataatc gacttgcaga acatattgta tctatgcttt
     8161 tcacatcaat agcaaagttg actcctgagg cagccaatcc tttctttaag ttgttgacta
     8221 tgctaatgga gtttgctggt ggacctccag gaatgcctcc ctttgcatct tatattctgc
     8281 agaggatatg ggaggtgatt gaatacaatc cttctcagtg tctagattgg ttggcagtgc
     8341 agacaccccg aaataaactg gcacacagct gggtcttaca gaatatggaa aactgggtcg
     8401 agcggtttct tttggctcac aattatccta gagtgaggac ttctgcagct tatcttctgg
     8461 tgtcccttat accaagcaat tcattccgtc agatgttccg gtcaacaagg tctttgcaca
     8521 tcccaacccg tgaccttcca ctcagtccag acacaacagt agtcctacat caggtctaca
     8581 acgtgctcct tggtttgctc tcaagagcca aactttatgt tgatgctgct gttcatggca
     8641 ctacaaagct agtgccctat tttagcttta tgacttactg tttaatttcc aaaactgaga
     8701 agctgatgtt ttccacatat ttcatggatt tgtggaacct tttccagcct aaactttctg
     8761 agccagcaat agctacaaat cacaataaac aggctttgct ttcattttgg tacaatgtct
     8821 gtgctgactg tccagagaat atccgcctta ttgttcagaa cccagtggta accaagaaca
     8881 ttgccttcaa ttacatcctt gctgaccatg atgatcagga tgtggtgctt tttaaccgtg
     8941 ggatgctgcc agcgtactat ggcattctga ggctctgctg tgagcagtct cctgcattca
     9001 cacgacaact ggcttctcac cagaacatcc agtgggcctt taagaatctt acaccacatg
     9061 ccagccaata ccctggagca gtagaagaac tgtttaacct gatgcagctg tttatagctc
     9121 agaggccaga tatgagagaa gaagaattag aagatattaa acagttcaag aaaacaacca
     9181 taagttgtta cttacgttgc ttagatggcc gctcctgctg gactacttta ataagtgcct
     9241 tcagaatact attagaatct gatgaagaca gacttcttgt tgtatttaat cgaggattga
     9301 ttctaatgac agagtctttc aacactttgc acatgatgta tcacgaagct acagcttgcc
     9361 atgtgactgg agatttagta gaacttctgt caatatttct ttcggttttg aagtctacac
     9421 gcccttatct tcagagaaaa gatgtgaaac aagcattaat ccagtggcag gagcgaattg
     9481 aatttgccca taaactgtta actcttctta attcctatag tcctccagaa cttagaaatg
     9541 cctgtataga tgtcctcaag gaacttgtac ttttgagtcc ccatgatttt cttcatactc
     9601 tggttccctt tctacaacac aaccattgta cttaccatca cagtaatata ccaatgtctc
     9661 ttggacctta tttcccttgt cgagaaaata tcaagctaat aggagggaaa agcaatattc
     9721 ggcctccgcg ccctgaactc aatatgtgcc tcttgcccac aatggtggaa accagtaagg
     9781 gcaaagatga cgtttatgat cgtatgctgc tagactactt cttttcttat catcagttca
     9841 tccatctatt atgccgagtt gcaatcaact gtgaaaaatt tactgaaaca ttagttaagc
     9901 tgagtgtcct agttgcctat gaaggtttgc cacttcatct tgcactgttc cccaaacttt
     9961 ggactgagct atgccagact cagtctgcta tgtcaaaaaa ctgcatcaag cttttgtgtg
    10021 aagatcctgt tttcgcagaa tatattaaat gtatcctaat ggatgaaaga acttttttaa
    10081 acaacaacat tgtctacacg ttcatgacac atttccttct aaaggttcaa agtcaagtgt
    10141 tttctgaagc aaactgtgcc aatttgatca gcactcttat tacaaacttg ataagccagt
    10201 atcagaacct acagtctgat ttctccaacc gagttgaaat ttccaaagca agtgcttctt
    10261 taaatgggga cctgagggca ctcgctttgc tcctgtcagt acacactccc aaacagttaa
    10321 acccagctct aattccaact ctgcaagagc ttttaagcaa atgcaggact tgtctgcaac
    10381 agagaaactc actccaagag caagaagcca aagaaagaaa aactaaagat gatgaaggag
    10441 caactcccat taaaaggcgg cgtgttagca gtgatgagga gcacactgta gacagctgca
    10501 tcagtgacat gaaaacagaa accagggagg tcctgacccc aacgagcact tctgacaatg
    10561 agaccagaga ctcctcaatt attgatccag gaactgagca agatcttcct tcccctgaaa
    10621 atagttctgt taaagaatac cgaatggaag ttccatcttc gttttcagaa gacatgtcaa
    10681 atatcaggtc acagcatgca gaagaacagt ccaacaatgg tagatatgac gattgtaaag
    10741 aatttaaaga cctccactgt tccaaggatt ctaccctagc tgaggaagaa tctgagttcc
    10801 cttctacttc tatctctgca gttctgtctg acttagctga cttgagaagc tgtgatggcc
    10861 aagctttgcc ctcccaggac cctgaggttg ctttatctct cagttgtggc cattccagag
    10921 gactctttag tcatatgcag caacatgaca ttttagatac cctgtgtagg accattgaat
    10981 ctacaatcca tgtcgtcaca aggatatctg gcaaaggaaa ccaagctgct tcttgacatt
    11041 aggtgtagca tgtctacttt taagtccctc acccccaacc cccatgctgt ttgtataagt
    11101 tttgcttatt tgtttttgtg cttcagtttg tccagtgctc tctgcttgaa tggcaagata
    11161 gatttatagg cttaattctt ggtcaggcag aactccagat gaaaaaaact tgcatcttca
    11221 gtatacttcc taaagggcaa tcagataatg gatatgtttt atgtaattaa gagttcactt
    11281 tagtggcttt catttaatat ggctgtctgg gaagaacagg gttgcctagc cctgtacaat
    11341 gtaatttaaa cttacagcat ttttactgtg tatgatatgg tgtcctctgt gccagttttg
    11401 taccttatag aggcagattg cctccgatcg ctgtggttct tattatcaaa attaagttta
    11461 cttgtatacg gaacaaccac aagaaatttg attctgtaaa gaatcctctt tagctgtggc
    11521 ctggcagtat ataaatggtg ctttatttaa cagaatacct gtggaggaaa taaagcacac
    11581 ttgatgtaaa aataattgtt ttatttttat tgacatgact gattgattga ttgctattct
    11641 gtgcacttaa ttaaactgat tgtgatgact tttca
//
