LOCUS       NM_032582               6937 bp    mRNA    linear   PRI 09-OCT-2024
DEFINITION  Homo sapiens ubiquitin specific peptidase 32 (USP32), mRNA.
ACCESSION   NM_032582 XM_496236
VERSION     NM_032582.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6937)
  AUTHORS   Su,W., Ahmad,I., Wu,Y., Tang,L., Khan,I., Ye,B., Liang,J., Li,S.
            and Zheng,Y.H.
  TITLE     Furin Egress from the TGN is Regulated by Membrane-Associated
            RING-CH Finger (MARCHF) Proteins and Ubiquitin-Specific Protease 32
            (USP32) via Nondegradable K33-Polyubiquitination
  JOURNAL   Adv Sci (Weinh) 11 (35), e2403732 (2024)
   PUBMED   39031635
  REMARK    GeneRIF: Furin Egress from the TGN is Regulated by
            Membrane-Associated RING-CH Finger (MARCHF) Proteins and
            Ubiquitin-Specific Protease 32 (USP32) via Nondegradable
            K33-Polyubiquitination.
REFERENCE   2  (bases 1 to 6937)
  AUTHORS   Xiu,M., Bao,W., Wang,J., Chen,J., Li,Y. and Hai,Y.
  TITLE     High USP32 expression contributes to cancer progression and is
            correlated with immune infiltrates in hepatocellular carcinoma
  JOURNAL   BMC Cancer 23 (1), 1105 (2023)
   PUBMED   37957631
  REMARK    GeneRIF: High USP32 expression contributes to cancer progression
            and is correlated with immune infiltrates in hepatocellular
            carcinoma.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 6937)
  AUTHORS   Zhang,H., Tao,Y., Ding,X., Wang,Y. and Wang,X.
  TITLE     Roles of the hsa_circ_0013880/USP32/Rap1b axis in the proliferation
            and apoptosis of acute myeloid leukemia cells
  JOURNAL   Acta Biochim Biophys Sin (Shanghai) 55 (3), 382-393 (2023)
   PUBMED   36951484
  REMARK    GeneRIF: Roles of the hsa_circ_0013880/USP32/Rap1b axis in the
            proliferation and apoptosis of acute myeloid leukemia cells.
REFERENCE   4  (bases 1 to 6937)
  AUTHORS   Li,C., Gao,Z., Cui,Z., Liu,Z., Bian,Y., Sun,H., Wang,N., He,Z.,
            Li,B., Li,F., Li,Z., Wang,L., Zhang,D., Yang,L., Xu,Z. and Xu,H.
  TITLE     Deubiquitylation of Rab35 by USP32 promotes the transmission of
            imatinib resistance by enhancing exosome secretion in
            gastrointestinal stromal tumours
  JOURNAL   Oncogene 42 (12), 894-910 (2023)
   PUBMED   36725886
  REMARK    GeneRIF: Deubiquitylation of Rab35 by USP32 promotes the
            transmission of imatinib resistance by enhancing exosome secretion
            in gastrointestinal stromal tumours.
REFERENCE   5  (bases 1 to 6937)
  AUTHORS   Hertel,A., Alves,L.M., Dutz,H., Tascher,G., Bonn,F., Kaulich,M.,
            Dikic,I., Eimer,S., Steinberg,F. and Bremm,A.
  TITLE     USP32-regulated LAMTOR1 ubiquitination impacts mTORC1 activation
            and autophagy induction
  JOURNAL   Cell Rep 41 (10), 111653 (2022)
   PUBMED   36476874
REFERENCE   6  (bases 1 to 6937)
  AUTHORS   Butland,S.L., Sanders,S.S., Schmidt,M.E., Riechers,S.P., Lin,D.T.,
            Martin,D.D., Vaid,K., Graham,R.K., Singaraja,R.R., Wanker,E.E.,
            Conibear,E. and Hayden,M.R.
  TITLE     The palmitoyl acyltransferase HIP14 shares a high proportion of
            interactors with huntingtin: implications for a role in the
            pathogenesis of Huntington's disease
  JOURNAL   Hum Mol Genet 23 (15), 4142-4160 (2014)
   PUBMED   24705354
REFERENCE   7  (bases 1 to 6937)
  AUTHORS   Akhavantabasi,S., Akman,H.B., Sapmaz,A., Keller,J., Petty,E.M. and
            Erson,A.E.
  TITLE     USP32 is an active, membrane-bound ubiquitin protease overexpressed
            in breast cancers
  JOURNAL   Mamm Genome 21 (7-8), 388-397 (2010)
   PUBMED   20549504
  REMARK    GeneRIF: USP32 is overexpressed in breast cancer.
REFERENCE   8  (bases 1 to 6937)
  AUTHORS   Puente,X.S., Sanchez,L.M., Overall,C.M. and Lopez-Otin,C.
  TITLE     Human and mouse proteases: a comparative genomic approach
  JOURNAL   Nat Rev Genet 4 (7), 544-558 (2003)
   PUBMED   12838346
  REMARK    Review article
REFERENCE   9  (bases 1 to 6937)
  AUTHORS   Paulding,C.A., Ruvolo,M. and Haber,D.A.
  TITLE     The Tre2 (USP6) oncogene is a hominoid-specific gene
  JOURNAL   Proc Natl Acad Sci U S A 100 (5), 2507-2511 (2003)
   PUBMED   12604796
REFERENCE   10 (bases 1 to 6937)
  AUTHORS   Scanlan,M.J., Gordan,J.D., Williamson,B., Stockert,E., Bander,N.H.,
            Jongeneel,V., Gure,A.O., Jager,D., Jager,E., Knuth,A., Chen,Y.T.
            and Old,L.J.
  TITLE     Antigens recognized by autologous antibody in patients with
            renal-cell carcinoma
  JOURNAL   Int J Cancer 83 (4), 456-464 (1999)
   PUBMED   10508479
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BI459907.1, AF533230.1, AL834444.1 and AC025048.8.
            
            On Nov 22, 2018 this sequence version replaced NM_032582.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803614.173635.1,
                                           SRR1803611.65237.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000300896.9/ ENSP00000300896.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-26                BI459907.1         102-127
            27-5170             AF533230.1         5-5148
            5171-6934           AL834444.1         1642-3405
            6935-6937           AC025048.8         126731-126733       c
FEATURES             Location/Qualifiers
     source          1..6937
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q23.1-q23.2"
     gene            1..6937
                     /gene="USP32"
                     /gene_synonym="NY-REN-60; USP10"
                     /note="ubiquitin specific peptidase 32"
                     /db_xref="GeneID:84669"
                     /db_xref="HGNC:HGNC:19143"
                     /db_xref="MIM:607740"
     exon            1..252
                     /gene="USP32"
                     /gene_synonym="NY-REN-60; USP10"
                     /inference="alignment:Splign:2.1.0"
     CDS             195..5009
                     /gene="USP32"
                     /gene_synonym="NY-REN-60; USP10"
                     /EC_number="3.4.19.12"
                     /note="ubiquitin specific protease 32; ubiquitin
                     thioesterase 32; deubiquitinating enzyme 32; renal
                     carcinoma antigen NY-REN-60; ubiquitin-specific-processing
                     protease 32; ubiquitin thiolesterase 32"
                     /codon_start=1
                     /product="ubiquitin carboxyl-terminal hydrolase 32"
                     /protein_id="NP_115971.2"
                     /db_xref="CCDS:CCDS32697.1"
                     /db_xref="GeneID:84669"
                     /db_xref="HGNC:HGNC:19143"
                     /db_xref="MIM:607740"
                     /translation="MGAKESRIGFLSYEEALRRVTDVELKRLKDAFKRTCGLSYYMGQ
                     HCFIREVLGDGVPPKVAEVIYCSFGGTSKGLHFNNLIVGLVLLTRGKDEEKAKYIFSL
                     FSSESGNYVIREEMERMLHVVDGKVPDTLRKCFSEGEKVNYEKFRNWLFLNKDAFTFS
                     RWLLSGGVYVTLTDDSDTPTFYQTLAGVTHLEESDIIDLEKRYWLLKAQSRTGRFDLE
                     TFGPLVSPPIRPSLSEGLFNAFDENRDNHIDFKEISCGLSACCRGPLAERQKFCFKVF
                     DVDRDGVLSRVELRDMVVALLEVWKDNRTDDIPELHMDLSDIVEGILNAHDTTKMGHL
                     TLEDYQIWSVKNVLANEFLNLLFQVCHIVLGLRPATPEEEGQIIRGWLERESRYGLQA
                     GHNWFIISMQWWQQWKEYVKYDANPVVIEPSSVLNGGKYSFGTAAHPMEQVEDRIGSS
                     LSYVNTTEEKFSDNISTASEASETAGSGFLYSATPGADVCFARQHNTSDNNNQCLLGA
                     NGNILLHLNPQKPGAIDNQPLVTQEPVKATSLTLEGGRLKRTPQLIHGRDYEMVPEPV
                     WRALYHWYGANLALPRPVIKNSKTDIPELELFPRYLLFLRQQPATRTQQSNIWVNMGN
                     VPSPNAPLKRVLAYTGCFSRMQTIKEIHEYLSQRLRIKEEDMRLWLYNSENYLTLLDD
                     EDHKLEYLKIQDEQHLVIEVRNKDMSWPEEMSFIANSSKIDRHKVPTEKGATGLSNLG
                     NTCFMNSSIQCVSNTQPLTQYFISGRHLYELNRTNPIGMKGHMAKCYGDLVQELWSGT
                     QKNVAPLKLRWTIAKYAPRFNGFQQQDSQELLAFLLDGLHEDLNRVHEKPYVELKDSD
                     GRPDWEVAAEAWDNHLRRNRSIVVDLFHGQLRSQVKCKTCGHISVRFDPFNFLSLPLP
                     MDSYMHLEITVIKLDGTTPVRYGLRLNMDEKYTGLKKQLSDLCGLNSEQILLAEVHGS
                     NIKNFPQDNQKVRLSVSGFLCAFEIPVPVSPISASSPTQTDFSSSPSTNEMFTLTTNG
                     DLPRPIFIPNGMPNTVVPCGTEKNFTNGMVNGHMPSLPDSPFTGYIIAVHRKMMRTEL
                     YFLSSQKNRPSLFGMPLIVPCTVHTRKKDLYDAVWIQVSRLASPLPPQEASNHAQDCD
                     DSMGYQYPFTLRVVQKDGNSCAWCPWYRFCRGCKIDCGEDRAFIGNAYIAVDWDPTAL
                     HLRYQTSQERVVDEHESVEQSRRAQAEPINLDSCLRAFTSEEELGENEMYYCSKCKTH
                     CLATKKLDLWRLPPILIIHLKRFQFVNGRWIKSQKIVKFPRESFDPSAFLVPRDPALC
                     QHKPLTPQGDELSEPRILAREVKKVDAQSSAGEEDVLLSKSPSSLSANIISSPKGSPS
                     SSRKSGTSCPSSKNSSPNSSPRTLGRSKGRLRLPQIGSKNKLSSSKENLDASKENGAG
                     QICELADALSRGHVLGGSQPELVTPQDHEVALANGFLYEHEACGNGYSNGQLGNHSEE
                     DSTDDQREDTRIKPIYNLYAISCHSGILGGGHYVTYAKNPNCKWYCYNDSSCKELHPD
                     EIDTDSAYILFYEQQGIDYAQFLPKTDGKKMADTSSMDEDFESDYKKYCVLQ"
     exon            253..380
                     /gene="USP32"
                     /gene_synonym="NY-REN-60; USP10"
                     /inference="alignment:Splign:2.1.0"
     exon            381..486
                     /gene="USP32"
                     /gene_synonym="NY-REN-60; USP10"
                     /inference="alignment:Splign:2.1.0"
     exon            487..605
                     /gene="USP32"
                     /gene_synonym="NY-REN-60; USP10"
                     /inference="alignment:Splign:2.1.0"
     exon            606..765
                     /gene="USP32"
                     /gene_synonym="NY-REN-60; USP10"
                     /inference="alignment:Splign:2.1.0"
     exon            766..897
                     /gene="USP32"
                     /gene_synonym="NY-REN-60; USP10"
                     /inference="alignment:Splign:2.1.0"
     exon            898..1005
                     /gene="USP32"
                     /gene_synonym="NY-REN-60; USP10"
                     /inference="alignment:Splign:2.1.0"
     exon            1006..1121
                     /gene="USP32"
                     /gene_synonym="NY-REN-60; USP10"
                     /inference="alignment:Splign:2.1.0"
     exon            1122..1184
                     /gene="USP32"
                     /gene_synonym="NY-REN-60; USP10"
                     /inference="alignment:Splign:2.1.0"
     exon            1185..1268
                     /gene="USP32"
                     /gene_synonym="NY-REN-60; USP10"
                     /inference="alignment:Splign:2.1.0"
     exon            1269..1330
                     /gene="USP32"
                     /gene_synonym="NY-REN-60; USP10"
                     /inference="alignment:Splign:2.1.0"
     exon            1331..1433
                     /gene="USP32"
                     /gene_synonym="NY-REN-60; USP10"
                     /inference="alignment:Splign:2.1.0"
     exon            1434..1626
                     /gene="USP32"
                     /gene_synonym="NY-REN-60; USP10"
                     /inference="alignment:Splign:2.1.0"
     exon            1627..1802
                     /gene="USP32"
                     /gene_synonym="NY-REN-60; USP10"
                     /inference="alignment:Splign:2.1.0"
     exon            1803..1943
                     /gene="USP32"
                     /gene_synonym="NY-REN-60; USP10"
                     /inference="alignment:Splign:2.1.0"
     exon            1944..2061
                     /gene="USP32"
                     /gene_synonym="NY-REN-60; USP10"
                     /inference="alignment:Splign:2.1.0"
     exon            2062..2216
                     /gene="USP32"
                     /gene_synonym="NY-REN-60; USP10"
                     /inference="alignment:Splign:2.1.0"
     exon            2217..2298
                     /gene="USP32"
                     /gene_synonym="NY-REN-60; USP10"
                     /inference="alignment:Splign:2.1.0"
     exon            2299..2373
                     /gene="USP32"
                     /gene_synonym="NY-REN-60; USP10"
                     /inference="alignment:Splign:2.1.0"
     exon            2374..2512
                     /gene="USP32"
                     /gene_synonym="NY-REN-60; USP10"
                     /inference="alignment:Splign:2.1.0"
     exon            2513..2618
                     /gene="USP32"
                     /gene_synonym="NY-REN-60; USP10"
                     /inference="alignment:Splign:2.1.0"
     exon            2619..2792
                     /gene="USP32"
                     /gene_synonym="NY-REN-60; USP10"
                     /inference="alignment:Splign:2.1.0"
     exon            2793..2967
                     /gene="USP32"
                     /gene_synonym="NY-REN-60; USP10"
                     /inference="alignment:Splign:2.1.0"
     exon            2968..3119
                     /gene="USP32"
                     /gene_synonym="NY-REN-60; USP10"
                     /inference="alignment:Splign:2.1.0"
     exon            3120..3231
                     /gene="USP32"
                     /gene_synonym="NY-REN-60; USP10"
                     /inference="alignment:Splign:2.1.0"
     exon            3232..3443
                     /gene="USP32"
                     /gene_synonym="NY-REN-60; USP10"
                     /inference="alignment:Splign:2.1.0"
     exon            3444..3628
                     /gene="USP32"
                     /gene_synonym="NY-REN-60; USP10"
                     /inference="alignment:Splign:2.1.0"
     exon            3629..3715
                     /gene="USP32"
                     /gene_synonym="NY-REN-60; USP10"
                     /inference="alignment:Splign:2.1.0"
     exon            3716..3836
                     /gene="USP32"
                     /gene_synonym="NY-REN-60; USP10"
                     /inference="alignment:Splign:2.1.0"
     exon            3837..4028
                     /gene="USP32"
                     /gene_synonym="NY-REN-60; USP10"
                     /inference="alignment:Splign:2.1.0"
     exon            4029..4317
                     /gene="USP32"
                     /gene_synonym="NY-REN-60; USP10"
                     /inference="alignment:Splign:2.1.0"
     exon            4318..4742
                     /gene="USP32"
                     /gene_synonym="NY-REN-60; USP10"
                     /inference="alignment:Splign:2.1.0"
     exon            4743..4835
                     /gene="USP32"
                     /gene_synonym="NY-REN-60; USP10"
                     /inference="alignment:Splign:2.1.0"
     exon            4836..6937
                     /gene="USP32"
                     /gene_synonym="NY-REN-60; USP10"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5138..5143
                     /regulatory_class="polyA_signal_sequence"
                     /gene="USP32"
                     /gene_synonym="NY-REN-60; USP10"
                     /note="hexamer: AATAAA"
     regulatory      5151..5156
                     /regulatory_class="polyA_signal_sequence"
                     /gene="USP32"
                     /gene_synonym="NY-REN-60; USP10"
                     /note="hexamer: ATTAAA"
     polyA_site      5164
                     /gene="USP32"
                     /gene_synonym="NY-REN-60; USP10"
                     /note="major polyA site"
     polyA_site      5170
                     /gene="USP32"
                     /gene_synonym="NY-REN-60; USP10"
     regulatory      6912..6917
                     /regulatory_class="polyA_signal_sequence"
                     /gene="USP32"
                     /gene_synonym="NY-REN-60; USP10"
                     /note="hexamer: AATAAA"
     polyA_site      6937
                     /gene="USP32"
                     /gene_synonym="NY-REN-60; USP10"
ORIGIN      
        1 cgtgatccgg catggaggcg gtggcggcga ccgggaggag ccgccggggc agaagccgca
       61 cttgttagtg tggggggagg tgggggcggg ggacgccgac accgtcaccg tcacccaggg
      121 acgccgagga gaaggcggga ggggggtggg ggcgagatca ggctccgacc ccccgccgag
      181 gggatgaggg gagcatgggt gccaaggagt cacggatcgg attcctcagc tacgaggagg
      241 cgctgaggag agttacagat gtagagctaa aacgactgaa ggatgctttc aagaggacct
      301 gtggactctc atattacatg ggccagcact gcttcatccg ggaagtgctt ggggatggag
      361 tgcctccaaa ggttgctgag gtgatttact gttcttttgg tggaacatcc aaagggctgc
      421 acttcaataa tttaatagtt ggacttgtcc tccttacaag aggcaaagat gaagagaaag
      481 caaaatacat ttttagtctt ttttcaagtg aatctgggaa ctatgttata cgggaagaaa
      541 tggaaagaat gctccacgtg gtggatggta aagtcccaga tacactcagg aagtgtttct
      601 cagagggtga aaaggtaaac tatgaaaagt ttagaaattg gctttttcta aacaaagatg
      661 cttttacttt ctctcgatgg cttctatctg gaggtgtgta tgttaccctc actgatgata
      721 gtgatactcc tactttctac caaactctgg ctggagtcac acatttggag gaatcagaca
      781 tcattgatct tgagaaacgc tattggttat tgaaggctca atcccggact ggacgatttg
      841 atttagagac atttggccca ttggtttcac cacctattcg tccatctcta agtgaaggtt
      901 tgtttaatgc ttttgatgaa aatcgtgaca atcacataga ttttaaggag atatcctgtg
      961 ggttatcagc ctgttgcagg ggacccctgg ctgaaagaca aaaattttgc ttcaaggtat
     1021 ttgatgttga ccgtgatgga gttctctcca gggttgaact gagagacatg gtggttgcac
     1081 ttttagaagt ctggaaggac aaccgcactg atgatattcc tgaattacat atggatctct
     1141 ctgatattgt agaaggcata ctgaatgcac atgacaccac aaagatgggt catcttactc
     1201 tggaagacta tcagatctgg agtgtgaaaa atgttcttgc caatgagttt ttgaacctcc
     1261 ttttccaggt gtgtcacata gttctggggt taagaccagc tactccggaa gaagaaggac
     1321 aaattattag aggatggtta gaacgagaga gcaggtatgg tctgcaagca ggacacaact
     1381 ggtttatcat ctccatgcag tggtggcaac agtggaaaga atatgtcaaa tacgatgcca
     1441 accctgtggt aattgagcca tcatctgttt tgaatggagg aaaatactca tttggaactg
     1501 cagcccatcc tatggagcag gtcgaagata gaattggaag cagcctcagt tacgtgaata
     1561 ctacagaaga gaaattttca gacaacattt ctactgcatc tgaagcctca gaaactgctg
     1621 gcagcggctt tctgtattct gccacaccag gggcagatgt ttgctttgct cgacaacata
     1681 acacttctga caataacaac cagtgtttgc tgggagccaa tgggaatatt ttgttgcacc
     1741 ttaaccctca gaaaccaggg gctattgata atcagccatt agtaactcaa gaaccagtaa
     1801 aggctacatc attaacacta gaaggaggac gattaaaacg aactccacag ctgattcatg
     1861 gaagagacta tgaaatggtc ccagaacctg tgtggagagc actttatcac tggtatggag
     1921 caaacctggc cttacctaga ccagttatca agaacagcaa gacagacatc ccagagctgg
     1981 aattatttcc ccgctatctt ctcttcctga gacagcagcc tgccactcgg acacagcagt
     2041 ctaacatctg ggtgaatatg ggaaatgtac cttctccgaa tgcaccttta aagcgggtat
     2101 tagcctatac aggctgtttt agtcgaatgc agaccatcaa ggaaattcac gaatatctat
     2161 ctcaaaggct gcgcattaaa gaggaagata tgcgcctgtg gctatacaac agtgagaact
     2221 accttactct tctggatgat gaggatcata aattggaata tttgaaaatc caggatgaac
     2281 aacacctggt aattgaagtt cgcaacaaag atatgagttg gcctgaggag atgtctttta
     2341 tagcaaatag tagtaaaata gatagacaca aggttcccac agaaaaggga gccacaggtc
     2401 taagcaatct gggaaacaca tgcttcatga actcaagcat ccagtgtgtt agtaacacac
     2461 agccactgac acagtatttt atctcaggga gacatcttta tgaactcaac aggacaaatc
     2521 ccattggtat gaaggggcat atggctaaat gctatggtga tttagtgcag gaactttgga
     2581 gtggaactca gaagaatgtt gccccattaa agcttcggtg gaccatagca aaatatgctc
     2641 ccaggtttaa tgggtttcag caacaggact cccaagaact tctggctttt ctcttggatg
     2701 gtcttcatga agatcttaat cgagtccatg aaaagccata tgtggaactg aaggacagtg
     2761 atgggcgacc agactgggaa gtagctgcag aggcctggga caaccatcta agaagaaata
     2821 gatcaattgt tgtggatttg ttccatgggc agctaagatc tcaagtaaaa tgcaagacat
     2881 gtgggcatat aagtgtccga tttgaccctt tcaatttttt gtctttgcca ctaccaatgg
     2941 acagttatat gcacttagaa ataacagtga ttaagttaga tggtactacc cctgtacggt
     3001 atggactaag actgaatatg gatgaaaagt acacaggttt aaaaaaacag ctgagtgatc
     3061 tctgtggact taattcagaa caaatccttc tagcagaagt acatggttcc aacataaaga
     3121 actttcctca ggacaaccaa aaagtacgac tctcagtgag tggatttttg tgtgcatttg
     3181 aaattcctgt ccctgtgtct ccaatttcag cttctagtcc aacacagaca gatttctcct
     3241 cttcgccatc tacaaatgaa atgttcaccc taactaccaa tggggaccta ccccgaccaa
     3301 tattcatccc caatggaatg ccaaacactg ttgtgccatg tggaactgag aagaacttca
     3361 caaatggaat ggttaatggt cacatgccat ctcttcctga cagccccttt acaggttaca
     3421 tcattgcagt ccaccgaaaa atgatgagga cagaactgta tttcctgtca tctcagaaga
     3481 atcgccccag cctctttgga atgccattga ttgttccatg tactgtgcat acccggaaga
     3541 aagacctata tgatgcggtt tggattcaag tatcccggtt agcgagccca ctcccacctc
     3601 aggaagctag taatcatgcc caggattgtg acgacagtat gggctatcaa tatccattca
     3661 ctctacgagt tgtgcagaaa gatgggaact cctgtgcttg gtgcccatgg tatagatttt
     3721 gcagaggctg taaaattgat tgtggggaag acagagcttt cattggaaat gcctatatcg
     3781 ctgtggattg ggatcccaca gcccttcacc ttcgctatca aacatcccag gaaagggttg
     3841 tagatgagca tgagagtgtg gagcagagtc ggcgagcgca agccgagccc atcaacctgg
     3901 acagctgtct ccgtgctttc accagtgagg aagagctagg ggaaaatgag atgtactact
     3961 gttccaagtg taagacccac tgcttagcaa caaagaagct ggatctctgg aggcttccac
     4021 ccatcctgat tattcacctt aagcgatttc aatttgtaaa tggtcggtgg ataaaatcac
     4081 agaaaattgt caaatttcct cgggaaagtt ttgatccaag tgcttttttg gtaccaagag
     4141 acccggctct ctgccagcat aaaccactca caccccaggg ggatgagctc tctgagccca
     4201 ggattctggc aagggaggtg aagaaagtgg atgcgcagag ttcggctggg gaagaggacg
     4261 tgctcctgag caaaagccca tcctcactca gcgctaacat catcagcagc ccgaaaggtt
     4321 ctccttcttc atcaagaaaa agtggaacca gctgtccctc cagcaaaaac agcagcccta
     4381 atagcagccc acggactttg gggaggagca aagggaggct ccggctgccc cagattggca
     4441 gcaaaaataa actgtcaagt agtaaagaga acttggatgc cagcaaagaa aatggggctg
     4501 ggcagatatg tgagctggct gacgccttga gtcgagggca tgtgctgggg ggcagccaac
     4561 cagagttggt cactcctcag gaccatgagg tagctttggc caatggattc ctttatgagc
     4621 atgaagcatg tggcaatggc tacagcaatg gtcagcttgg aaaccacagt gaagaagaca
     4681 gcactgatga ccaaagagaa gatactcgta ttaagcctat ttataatcta tatgcaattt
     4741 cgtgccattc aggaattctg ggtgggggcc attacgtcac ttatgccaaa aacccaaact
     4801 gcaagtggta ctgttacaat gacagcagct gtaaggaact tcacccggat gaaattgaca
     4861 ccgactctgc ctacattctt ttctatgagc agcaggggat agactatgca caatttctgc
     4921 caaagactga tggcaaaaag atggcagaca caagcagtat ggatgaagac tttgagtctg
     4981 attacaaaaa gtactgtgtg ttacagtaaa gctaccactc tggctgctag acagcttggc
     5041 ggtgagggag atgactcctt gtagctgaca tttggcaaaa gcgtcactga aaggcaagct
     5101 aaatgtagtt attttatcct gtggccctga agcacaaaat aaaaattcta attaaaatag
     5161 ttaactttaa gagtagtaat cattttattt tgaagtctca tacaagctct ccgatagaga
     5221 actttcaggc agatcccacc attagcctgt aaacaaaagg tttggcacca gccacctggg
     5281 accaaataag aattcaattg tgcttgtcca gatatgaaca aatatgtagt gagtatagag
     5341 tttaccataa tcataacaaa tattaaagat ttccttggag tcagagtaaa aaacaaacaa
     5401 ttataatgtt gtctagggac gacatgatat gctacctcct ttttcctgaa gttttattcc
     5461 attatattga caagatggag aaagcaagat cacgaaggtg tgcaaatgat tcttaaggca
     5521 tggacgagga tttttcaatt tattttttaa actgtttcca taccctttct ttgtctttct
     5581 tgctttttgt ttttgccgtt gtatttatgt ttgagacaca accagtcatt ggtggcaggg
     5641 gcatatagtg gtcagtctga aagggaggct ctcttaagag ctgtgtgcct tccacccaga
     5701 gccttgtggg agacccagta gaaagaaaca gcatcctggg aaatccagct accatggccc
     5761 tcccagtgga ggcatcttac atttaggata cttcaagtat cctcagaaat gtattctgca
     5821 cccccggccc cacccatgct gagggaaggg gagcagttgc caatatttgc accatcttca
     5881 catgcacctg ttgcaacaag agcttctggg aaggtaagtg gcattggagc tagatcacgt
     5941 ttcacaatta gtggttgttc ttttctgtgt ttgtcttgca ctttaaaaaa gagagaacac
     6001 atgcaaatga acttgcttgt gtgtatttga tggctctaag ggctataaat tacaaacaaa
     6061 acacatccca gacattagga gttcataagt gtatttaatg aaattggtgg ttttaggaag
     6121 tcaactttag ttttgctttg tttgcatgtc cactaatttt tttattttga tatttgtctt
     6181 ttttttaaat tttacagtag tcatcgaaag ttatgtttct ttgcttactt catttttttc
     6241 tctaatcaag actggaacaa aagtataaat attatttatt tcaggtagca tttttttcgt
     6301 gtagtttttt aatatatact tgaaggaaat gtttcacctt atttttggtc tttgtttatt
     6361 catttagacc ctgcaagttg attctcatta attgtcagat tccactaccc tttcttcctc
     6421 atagatagta attaccaatg taactaagta tttgtgttct gatatctgag gccagtaact
     6481 attaatatct agttctcaga gcatttggaa aggttatctt aaatggctac ctaaattgaa
     6541 atccttttca gaaaaaatat aattgcaagt aggtaggact ggcctaaatt gtctaatgta
     6601 ataaagtcag acaaaatgca tactttatag tttcaagatt ttcagtatat aaaatctgtc
     6661 cattcccatt aaaaagtgga agattttaaa taatttcttt acagatgttt tatttaagca
     6721 ggtagctcaa tctactaatg ttgtttgatc tgtgtttgtt atactggttg taattaattt
     6781 ttttaattca tgaactagca gaaaatttat taaattaact attaactaca ttcaccttgt
     6841 aaattactgt ataaaacttg ttgacaatgc actgacttta gaaagatgtt aatgtacata
     6901 aatagagtgt aaataaaata gtgttgatgt accgaaa
//
