LOCUS       NM_020903               3763 bp    mRNA    linear   PRI 22-SEP-2024
DEFINITION  Homo sapiens ubiquitin specific peptidase 29 (USP29), transcript
            variant 1, mRNA.
ACCESSION   NM_020903
VERSION     NM_020903.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3763)
  AUTHORS   Tu,R., Kang,Y., Pan,Y., Da,Y., Ren,D., Zhang,R., Cai,Z., Liu,Y.,
            Xu,J., Ma,J., Zhou,Z., Yin,S., Li,X., Zhang,P., Zhang,Q., Wang,J.,
            Lu,X. and Zhang,C.
  TITLE     USP29 activation mediated by FUBP1 promotes AURKB stability and
            oncogenic functions in gastric cancer
  JOURNAL   Cancer Cell Int 24 (1), 33 (2024)
   PUBMED   38233848
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3763)
  AUTHORS   Guan,T., Li,M., Song,Y., Chen,J., Tang,J., Zhang,C., Wen,Y.,
            Yang,X., Huang,L., Zhu,Y., Wang,H., Ding,K., Zheng,J., Zhang,H. and
            Liu,T.
  TITLE     Phosphorylation of USP29 by CDK1 Governs TWIST1 Stability and
            Oncogenic Functions
  JOURNAL   Adv Sci (Weinh) 10 (11), e2205873 (2023)
   PUBMED   36782089
  REMARK    GeneRIF: Phosphorylation of USP29 by CDK1 Governs TWIST1 Stability
            and Oncogenic Functions.
REFERENCE   3  (bases 1 to 3763)
  AUTHORS   Gao,W., Wang,L., Ju,X., Zhao,S., Li,Z., Su,M., Xu,J., Wang,P.,
            Ding,Q., Lv,G. and Zhang,W.
  TITLE     The Deubiquitinase USP29 Promotes SARS-CoV-2 Virulence by
            Preventing Proteasome Degradation of ORF9b
  JOURNAL   mBio 13 (3), e0130022 (2022)
   PUBMED   35638730
  REMARK    GeneRIF: The Deubiquitinase USP29 Promotes SARS-CoV-2 Virulence by
            Preventing Proteasome Degradation of ORF9b.
REFERENCE   4  (bases 1 to 3763)
  AUTHORS   Tu,R., Kang,W., Yang,M., Wang,L., Bao,Q., Chen,Z., Dong,Y.,
            Wang,J., Jiang,J., Liu,H. and Qing,G.
  TITLE     USP29 coordinates MYC and HIF1alpha stabilization to promote tumor
            metabolism and progression
  JOURNAL   Oncogene 40 (46), 6417-6429 (2021)
   PUBMED   34601505
  REMARK    GeneRIF: USP29 coordinates MYC and HIF1alpha stabilization to
            promote tumor metabolism and progression.
REFERENCE   5  (bases 1 to 3763)
  AUTHORS   Chandrasekaran,A.P., Woo,S.H., Sarodaya,N., Rhie,B.H., Tyagi,A.,
            Das,S., Suresh,B., Ko,N.R., Oh,S.J., Kim,K.S. and Ramakrishna,S.
  TITLE     Ubiquitin-Specific Protease 29 Regulates Cdc25A-Mediated
            Tumorigenesis
  JOURNAL   Int J Mol Sci 22 (11), 5766 (2021)
   PUBMED   34071237
  REMARK    GeneRIF: Ubiquitin-Specific Protease 29 Regulates Cdc25A-Mediated
            Tumorigenesis.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3763)
  AUTHORS   Martin,Y., Cabrera,E., Amoedo,H., Hernandez-Perez,S.,
            Dominguez-Kelly,R. and Freire,R.
  TITLE     USP29 controls the stability of checkpoint adaptor Claspin by
            deubiquitination
  JOURNAL   Oncogene 34 (8), 1058-1063 (2015)
   PUBMED   24632611
  REMARK    GeneRIF: USP29 interacts with Claspin and is able to deubiquitinate
            it both in vivo and in vitro.
REFERENCE   7  (bases 1 to 3763)
  AUTHORS   Sowa,M.E., Bennett,E.J., Gygi,S.P. and Harper,J.W.
  TITLE     Defining the human deubiquitinating enzyme interaction landscape
  JOURNAL   Cell 138 (2), 389-403 (2009)
   PUBMED   19615732
REFERENCE   8  (bases 1 to 3763)
  AUTHORS   Puente,X.S., Sanchez,L.M., Overall,C.M. and Lopez-Otin,C.
  TITLE     Human and mouse proteases: a comparative genomic approach
  JOURNAL   Nat Rev Genet 4 (7), 544-558 (2003)
   PUBMED   12838346
  REMARK    Review article
REFERENCE   9  (bases 1 to 3763)
  AUTHORS   Tureci,O., Sahin,U., Koslowski,M., Buss,B., Bell,C., Ballweber,P.,
            Zwick,C., Eberle,T., Zuber,M., Villena-Heinsen,C., Seitz,G. and
            Pfreundschuh,M.
  TITLE     A novel tumour associated leucine zipper protein targeting to sites
            of gene transcription and splicing
  JOURNAL   Oncogene 21 (24), 3879-3888 (2002)
   PUBMED   12032826
REFERENCE   10 (bases 1 to 3763)
  AUTHORS   Kim,J., Noskov,V.N., Lu,X., Bergmann,A., Ren,X., Warth,T.,
            Richardson,P., Kouprina,N. and Stubbs,L.
  TITLE     Discovery of a novel, paternally expressed ubiquitin-specific
            processing protease gene through comparative analysis of an
            imprinted region of mouse chromosome 7 and human chromosome 19q13.4
  JOURNAL   Genome Res 10 (8), 1138-1147 (2000)
   PUBMED   10958632
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC025588.1.
            
            On Jan 8, 2021 this sequence version replaced NM_020903.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK308285.1, DB086580.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000254181.9/ ENSP00000254181.3
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-245               AC025588.1         62499-62743
            246-395             AC025588.1         64839-64988
            396-496             AC025588.1         66553-66653
            497-3763            AC025588.1         71174-74440
FEATURES             Location/Qualifiers
     source          1..3763
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.43"
     gene            1..3763
                     /gene="USP29"
                     /gene_synonym="HOM-TES-84/86"
                     /note="ubiquitin specific peptidase 29"
                     /db_xref="GeneID:57663"
                     /db_xref="HGNC:HGNC:18563"
                     /db_xref="MIM:609546"
     exon            1..245
                     /gene="USP29"
                     /gene_synonym="HOM-TES-84/86"
                     /inference="alignment:Splign:2.1.0"
     exon            246..395
                     /gene="USP29"
                     /gene_synonym="HOM-TES-84/86"
                     /inference="alignment:Splign:2.1.0"
     exon            396..496
                     /gene="USP29"
                     /gene_synonym="HOM-TES-84/86"
                     /inference="alignment:Splign:2.1.0"
     exon            497..3763
                     /gene="USP29"
                     /gene_synonym="HOM-TES-84/86"
                     /inference="alignment:Splign:2.1.0"
     CDS             513..3281
                     /gene="USP29"
                     /gene_synonym="HOM-TES-84/86"
                     /EC_number="3.4.19.12"
                     /note="isoform 1 is encoded by transcript variant 1;
                     ubiquitin-specific processing protease; ubiquitin
                     carboxyl-terminal hydrolase 29; ubiquitin thiolesterase
                     29; deubiquitinating enzyme 29; ubiquitin thioesterase 29;
                     ubiquitin-specific-processing protease 29"
                     /codon_start=1
                     /product="ubiquitin carboxyl-terminal hydrolase 29 isoform
                     1"
                     /protein_id="NP_065954.1"
                     /db_xref="CCDS:CCDS33124.1"
                     /db_xref="GeneID:57663"
                     /db_xref="HGNC:HGNC:18563"
                     /db_xref="MIM:609546"
                     /translation="MISLKVCGFIQIWSQKTGMTKLKEALIETVQRQKEIKLVVTFKS
                     GKFIRIFQLSNNIRSVVLRHCKKRQSHLRLTLKNNVFLFIDKLSYRDAKQLNMFLDII
                     HQNKSQQPMKSDDDWSVFESRNMLKEIDKTSFYSICNKPSYQKMPLFMSKSPTHVKKG
                     ILENQGGKGQNTLSSDVQTNEDILKEDNPVPNKKYKTDSLKYIQSNRKNPSSLEDLEK
                     DRDLKLGPSFNTNCNGNPNLDETVLATQTLNAKNGLTSPLEPEHSQGDPRCNKAQVPL
                     DSHSQQLQQGFPNLGNTCYMNAVLQSLFAIPSFADDLLTQGVPWEYIPFEALIMTLTQ
                     LLALKDFCSTKIKRELLGNVKKVISAVAEIFSGNMQNDAHEFLGQCLDQLKEDMEKLN
                     ATLNTGKECGDENSSPQMHVGSAATKVFVCPVVANFEFELQLSLICKACGHAVLKVEP
                     NNYLSINLHQETKPLPLSIQNSLDLFFKEEELEYNCQMCKQKSCVARHTFSRLSRVLI
                     IHLKRYSFNNAWLLVKNNEQVYIPKSLSLSSYCNESTKPPLPLSSSAPVGKCEVLEVS
                     QEMISEINSPLTPSMKLTSESSDSLVLPVEPDKNADLQRFQRDCGDASQEQHQRDLEN
                     GSALESELVHFRDRAIGEKELPVADSLMDQGDISLPVMYEDGGKLISSPDTRLVEVHL
                     QEVPQHPELQKYEKTNTFVEFNFDSVTESTNGFYDCKENRIPEGSQGMAEQLQQCIEE
                     SIIDEFLQQAPPPGVRKLDAQEHTEETLNQSTELRLQKADLNHLGALGSDNPGNKNIL
                     DAENTRGEAKELTRNVKMGDPLQAYRLISVVSHIGSSPNSGHYISDVYDFQKQAWFTY
                     NDLCVSEISETKMQEARLHSGYIFFYMHNGIFEELLRKAENSRLPSTQAGVIPQGEYE
                     GDSLYRPA"
     regulatory      3744..3749
                     /regulatory_class="polyA_signal_sequence"
                     /gene="USP29"
                     /gene_synonym="HOM-TES-84/86"
                     /note="hexamer: TATAAA"
     polyA_site      3763
                     /gene="USP29"
                     /gene_synonym="HOM-TES-84/86"
                     /note="major polyA site"
ORIGIN      
        1 actcttctgt tcccaggaga atcaggggag tcggcgccgg aaggggcggg tccgagctga
       61 gatttccaga gccatgggag ccggaagtcc aaggaactgt acctccatca tgacgactcc
      121 ggttacgtaa aaacattcaa acagaaaatg ctggccaggc tcatgcctgt aatcccagca
      181 ctttgggagg ccgaggcggg aggatcgctt gtgcccagga gttggagacc agcctgggca
      241 acatagcgct atggagtcta atccaggcac tttggaaggc tgaggctgga ggatcgattg
      301 aggccaggag tttgggacca ccctgggcaa catagcaaga tctcatttct gaaaaaagaa
      361 ttatcatcca ctcacccaga acagctctcc aaacttaaca gccgtggcag tcagagctct
      421 gcctgcagtg tgaccatgga cagctctcca aagcttaaac ttcagtaaat tgactcaagt
      481 ttcttcggaa agaactgtta cataaagaaa ggatgatatc tctaaaggta tgtggattca
      541 tccaaatttg gagccagaag actgggatga ctaagctgaa agaagctctc attgaaacag
      601 tgcaaagaca aaaggaaatt aaactggtgg tcactttcaa atctggaaaa tttataagaa
      661 tttttcagct gagcaacaac attagaagtg tggtccttag acattgtaaa aaaagacaaa
      721 gtcacctgcg tttaactttg aaaaacaacg tgttcttgtt tattgacaaa ttatcctaca
      781 gagatgctaa acagttgaat atgttcctgg acataatcca ccaaaacaaa tctcagcaac
      841 ccatgaaatc tgatgatgat tggagtgtgt ttgaaagcag gaatatgctg aaggaaattg
      901 acaaaacttc attttacagc atttgtaaca agccaagtta tcagaagatg cctttgttta
      961 tgtcaaaatc accaacacat gtgaaaaagg ggatattaga aaatcaaggt gggaaggggc
     1021 aaaacacact atcatctgat gtacagacaa atgaggacat tctgaaggaa gataaccctg
     1081 taccaaacaa gaaatataag acagattcct tgaaatatat acaaagcaat aggaagaacc
     1141 catcaagttt agaggattta gaaaaagata gagatttgaa actcgggcct tcattcaata
     1201 ccaactgtaa tggaaatcct aacctagatg agactgttct tgcaacccag actctcaatg
     1261 ccaaaaatgg tttgacatct ccattggaac cagagcacag ccagggtgac ccaagatgca
     1321 acaaagccca ggtgcctctt gactctcatt cacagcaact gcagcagggg ttccccaatt
     1381 tgggaaacac ctgttacatg aatgcagttt tacaatcgct atttgcaatt ccatcttttg
     1441 ctgatgactt actcactcaa ggtgtcccat gggaatatat tccctttgag gctcttatta
     1501 tgaccttgac ccagctgctt gctttgaaag atttctgtag tacaaagatc aagagagaat
     1561 tacttgggaa tgttaaaaaa gtcatttcag cagttgcaga aatattttct ggcaacatgc
     1621 agaatgatgc tcatgagttt ttaggtcagt gtttagacca gctgaaagaa gacatggaaa
     1681 aattaaatgc cactttgaat actgggaaag aatgtgggga tgaaaattca tctccacaaa
     1741 tgcatgttgg tagtgctgcc accaaagtgt ttgtttgccc tgttgttgct aattttgagt
     1801 ttgaattgca gctctccctt atttgtaaag cttgtggtca tgctgttctc aaggtagaac
     1861 ctaataatta tctctccatc aacctgcacc aagaaacaaa accacttcct ttgtccattc
     1921 agaattcttt agatcttttc tttaaagaag aagagcttga atataactgt cagatgtgta
     1981 agcagaagag ttgtgttgca aggcatacat ttagtaggct ctccagggtc cttatcattc
     2041 atctgaaacg ctatagcttc aacaatgctt ggttgctggt gaagaataac gagcaagttt
     2101 atattcccaa atctttaagt ttatcttctt attgcaatga aagcaccaaa ccacctcttc
     2161 ccttgagcag tagtgcacct gttgggaaat gtgaagtcct ggaagtctct caggagatga
     2221 tttctgagat caacagccca ttgacaccat caatgaagct gacctcagaa tccagtgatt
     2281 ccctggttct acccgttgaa ccagacaaga atgccgacct acaaagattc cagagagact
     2341 gtggagatgc aagccaagag cagcatcaga gagacctgga aaatggctct gcactagagt
     2401 cagaattggt ccactttaga gatagggcaa tcggtgaaaa ggagcttcca gtggctgact
     2461 cactgatgga ccagggagac atttctcttc ctgtgatgta tgaagatgga gggaagctga
     2521 tcagcagccc agacacaagg cttgtcgagg ttcatcttca agaggtgcct caacatccag
     2581 aacttcagaa gtatgagaaa accaatacat tcgtagagtt caattttgac agtgtcactg
     2641 agtccaccaa tggcttttat gactgtaaag aaaacaggat tccagaagga tctcaaggaa
     2701 tggctgaaca gctccagcag tgtattgagg agagcatcat agatgaattt cttcagcagg
     2761 caccacctcc aggtgttagg aagctggatg cccaggaaca tacagaagag accctcaatc
     2821 agtctacaga attaagactt caaaaggctg acctgaatca ccttggggca ctgggttctg
     2881 acaacccagg aaacaaaaac attttagatg cagagaacac aagaggtgaa gccaaggaac
     2941 taacaagaaa cgtgaagatg ggggatcctc tccaggccta cagactcatc agtgttgtca
     3001 gccatatcgg gagctcccca aattcaggcc attacatcag cgatgtgtat gactttcaga
     3061 agcaggcctg gttcacatac aacgatctat gtgtatcaga aatctcagag accaaaatgc
     3121 aggaggcgag gcttcactct gggtatatct tcttttacat gcacaatggg atttttgagg
     3181 agctgttaag aaaagcagag aactctcggc tacctagcac acaggcaggg gtgatccctc
     3241 agggggaata cgaaggtgac tctttgtaca gacctgcttg acagactcac tcggcctcac
     3301 ttcatccttg caaagagaat cctgtacttc atccttgcaa agagaatcct gtacttcact
     3361 cagaatgaag gaacaagtat ctcaggatga aatctcaatg aaaaacactt attttggggg
     3421 aatatctatt ttaactgctt cagacaccta gatcccagaa ctcaggcgca tatgcatatt
     3481 ttccctgcaa gattagaatg gtgctcttca cgttttgacg gtggttttca aaatgttgtt
     3541 cttcaaccag caacagcaac agctagggac tgattagaaa tgcaaattct tgggtcactc
     3601 tctagaccaa ctgatgcaga aacaggaggt gtgagccagc aatcagatgg agattctagt
     3661 gctcatgaaa gtttgaagaa cactggtaat gtgtggagta tcttggtgta ttttgctact
     3721 gttgatatgg attgcttatg ttatataaac gattttcatt aaa
//
