LOCUS       NM_001145073            3075 bp    mRNA    linear   PRI 09-FEB-2025
DEFINITION  Homo sapiens ubiquitin specific peptidase 27 X-linked (USP27X),
            mRNA.
ACCESSION   NM_001145073 XM_001714049 XM_372213 XM_937860
VERSION     NM_001145073.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3075)
  AUTHORS   Koch,I., Slovik,M., Zhang,Y., Liu,B., Rennie,M., Konz,E., Cogne,B.,
            Daana,M., Davids,L., Diets,I.J., Gold,N.B., Holtz,A.M., Isidor,B.,
            Mor-Shaked,H., Neira Fresneda,J., Niederhoffer,K.Y., Nizon,M.,
            Pfundt,R., Simon,M., Stegmann,A., Guillen Sacoto,M.J., Wevers,M.,
            Barakat,T.S., Yanovsky-Dagan,S., Atanassov,B.S., Toth,R., Gao,C.,
            Bustos,F. and Harel,T.
  TITLE     USP27X variants underlying X-linked intellectual disability disrupt
            protein function via distinct mechanisms
  JOURNAL   Life Sci Alliance 7 (3), e202302258 (2024)
   PUBMED   38182161
  REMARK    GeneRIF: USP27X variants underlying X-linked intellectual
            disability disrupt protein function via distinct mechanisms.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3075)
  AUTHORS   Xing,Y., Ba-Tu,J., Dong,C., Cao,X., Li,B., Jia,X., Juan,Y., Lv,X.,
            Zhang,H., Qin,N., Han,W., Wang,D., Qi,X., Wang,Y., Hao,X.,
            Zhang,S., Du,X., Wang,H. and Wang,M.
  TITLE     Phosphorylation of USP27X by GSK3beta maintains the stability and
            oncogenic functions of CBX2
  JOURNAL   Cell Death Dis 14 (11), 782 (2023)
   PUBMED   38030604
  REMARK    GeneRIF: Phosphorylation of USP27X by GSK3beta maintains the
            stability and oncogenic functions of CBX2.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3075)
  AUTHORS   Dold,M.N., Ng,X., Alber,C., Gentle,I.E., Hacker,G. and Weber,A.
  TITLE     The deubiquitinase Usp27x as a novel regulator of cFLIPL protein
            expression and sensitizer to death-receptor-induced apoptosis
  JOURNAL   Apoptosis 27 (1-2), 112-132 (2022)
   PUBMED   35044632
  REMARK    GeneRIF: The deubiquitinase Usp27x as a novel regulator of cFLIPL
            protein expression and sensitizer to death-receptor-induced
            apoptosis.
REFERENCE   4  (bases 1 to 3075)
  AUTHORS   Zou,T., Wang,Y., Dong,L., Che,T., Zhao,H., Yan,X. and Lin,Z.
  TITLE     Stabilization of SETD3 by deubiquitinase USP27 enhances cell
            proliferation and hepatocellular carcinoma progression
  JOURNAL   Cell Mol Life Sci 79 (1), 70 (2022)
   PUBMED   35018513
  REMARK    GeneRIF: Stabilization of SETD3 by deubiquitinase USP27 enhances
            cell proliferation and hepatocellular carcinoma progression.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3075)
  AUTHORS   Lambies,G., Miceli,M., Martinez-Guillamon,C., Olivera-Salguero,R.,
            Pena,R., Frias,C.P., Calderon,I., Atanassov,B.S., Dent,S.Y.R.,
            Arribas,J., Garcia de Herreros,A. and Diaz,V.M.
  TITLE     TGFbeta-Activated USP27X Deubiquitinase Regulates Cell Migration
            and Chemoresistance via Stabilization of Snail1
  JOURNAL   Cancer Res 79 (1), 33-46 (2019)
   PUBMED   30341066
  REMARK    GeneRIF: High USP27X expression is associated with Chemoresistance
            in breast cancer by Stabilization of Snail1.
REFERENCE   6  (bases 1 to 3075)
  AUTHORS   Dong,L., Yu,L., Bai,C., Liu,L., Long,H., Shi,L. and Lin,Z.
  TITLE     USP27-mediated Cyclin E stabilization drives cell cycle progression
            and hepatocellular tumorigenesis
  JOURNAL   Oncogene 37 (20), 2702-2713 (2018)
   PUBMED   29497124
  REMARK    GeneRIF: Data found that USP27 promotes Cyclin E stability by
            negatively regulating its ubiquitination and regulates its
            abundance to accelerate cell cycle progression, cell proliferation,
            and hepatocellular carcinoma cell growth as well.
REFERENCE   7  (bases 1 to 3075)
  AUTHORS   Atanassov,B.S., Mohan,R.D., Lan,X., Kuang,X., Lu,Y., Lin,K.,
            McIvor,E., Li,W., Zhang,Y., Florens,L., Byrum,S.D.,
            Mackintosh,S.G., Calhoun-Davis,T., Koutelou,E., Wang,L., Tang,D.G.,
            Tackett,A.J., Washburn,M.P., Workman,J.L. and Dent,S.Y.
  TITLE     ATXN7L3 and ENY2 Coordinate Activity of Multiple H2B
            Deubiquitinases Important for Cellular Proliferation and Tumor
            Growth
  JOURNAL   Mol Cell 62 (4), 558-571 (2016)
   PUBMED   27132940
  REMARK    GeneRIF: ATXN7L3 and ENY2 orchestrate activities of multiple
            deubiquitinating enzymes, including USP27x and USP51, and that
            imbalances in these activities likely potentiate human diseases
            including cancer.
REFERENCE   8  (bases 1 to 3075)
  AUTHORS   Weber,A., Heinlein,M., Dengjel,J., Alber,C., Singh,P.K. and
            Hacker,G.
  TITLE     The deubiquitinase Usp27x stabilizes the BH3-only protein Bim and
            enhances apoptosis
  JOURNAL   EMBO Rep 17 (5), 724-738 (2016)
   PUBMED   27013495
  REMARK    GeneRIF: Usp27x can trigger via its proteolytic activity the
            deubiquitination of Bim and enhance its levels, counteracting the
            anti-apoptotic effects of ERK activity, and therefore acts as a
            tumour suppressor.
REFERENCE   9  (bases 1 to 3075)
  AUTHORS   Hu,H., Haas,S.A., Chelly,J., Van Esch,H., Raynaud,M., de
            Brouwer,A.P., Weinert,S., Froyen,G., Frints,S.G., Laumonnier,F.,
            Zemojtel,T., Love,M.I., Richard,H., Emde,A.K., Bienek,M.,
            Jensen,C., Hambrock,M., Fischer,U., Langnick,C., Feldkamp,M.,
            Wissink-Lindhout,W., Lebrun,N., Castelnau,L., Rucci,J.,
            Montjean,R., Dorseuil,O., Billuart,P., Stuhlmann,T., Shaw,M.,
            Corbett,M.A., Gardner,A., Willis-Owen,S., Tan,C., Friend,K.L.,
            Belet,S., van Roozendaal,K.E., Jimenez-Pocquet,M., Moizard,M.P.,
            Ronce,N., Sun,R., O'Keeffe,S., Chenna,R., van Bommel,A., Goke,J.,
            Hackett,A., Field,M., Christie,L., Boyle,J., Haan,E., Nelson,J.,
            Turner,G., Baynam,G., Gillessen-Kaesbach,G., Muller,U.,
            Steinberger,D., Budny,B., Badura-Stronka,M., Latos-Bielenska,A.,
            Ousager,L.B., Wieacker,P., Rodriguez Criado,G., Bondeson,M.L.,
            Anneren,G., Dufke,A., Cohen,M., Van Maldergem,L.,
            Vincent-Delorme,C., Echenne,B., Simon-Bouy,B., Kleefstra,T.,
            Willemsen,M., Fryns,J.P., Devriendt,K., Ullmann,R., Vingron,M.,
            Wrogemann,K., Wienker,T.F., Tzschach,A., van Bokhoven,H., Gecz,J.,
            Jentsch,T.J., Chen,W., Ropers,H.H. and Kalscheuer,V.M.
  TITLE     X-exome sequencing of 405 unresolved families identifies seven
            novel intellectual disability genes
  JOURNAL   Mol Psychiatry 21 (1), 133-148 (2016)
   PUBMED   25644381
REFERENCE   10 (bases 1 to 3075)
  AUTHORS   Puente,X.S., Sanchez,L.M., Overall,C.M. and Lopez-Otin,C.
  TITLE     Human and mouse proteases: a comparative genomic approach
  JOURNAL   Nat Rev Genet 4 (7), 544-558 (2003)
   PUBMED   12838346
  REMARK    Review article
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC236430.4.
            This sequence is a reference standard in the RefSeqGene project.
            
            On May 17, 2019 this sequence version replaced NM_001145073.2.
            
            Summary: This gene encodes a member of the peptidase protein
            family. The encoded protein functions as a deubiquitinase that is
            involved in upregulation of the pro-apoptotic Bim protein. This
            protein may act as a tumor suppressor by increasing levels of Bim
            to counteract anti-apoptotic signals in cancer cells. Mutations in
            this gene have been associated with X-linked cognitive disability.
            [provided by RefSeq, Dec 2016].
            
            Sequence Note: The RefSeq transcript was derived from the reference
            genome assembly. The genomic coordinates were determined from
            alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript is intronless :: ERR279876.4827.1, DRR138528.6382.1
                                        [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000621775.2/ ENSP00000483631.1
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3075              AC236430.4         86247-89321
FEATURES             Location/Qualifiers
     source          1..3075
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /map="Xp11.23"
     gene            1..3075
                     /gene="USP27X"
                     /gene_synonym="MRX105; USP22L; USP27; XLID105"
                     /note="ubiquitin specific peptidase 27 X-linked"
                     /db_xref="GeneID:389856"
                     /db_xref="HGNC:HGNC:13486"
                     /db_xref="MIM:300975"
     exon            1..3075
                     /gene="USP27X"
                     /gene_synonym="MRX105; USP22L; USP27; XLID105"
                     /inference="alignment:Splign:2.1.0"
     CDS             825..2141
                     /gene="USP27X"
                     /gene_synonym="MRX105; USP22L; USP27; XLID105"
                     /EC_number="3.4.19.12"
                     /note="deubiquitinating enzyme 27; X-linked ubiquitin
                     carboxyl-terminal hydrolase 27; ubiquitin specific
                     protease 27, X chromosome; ubiquitin thioesterase 27;
                     ubiquitin-specific-processing protease 27"
                     /codon_start=1
                     /product="ubiquitin carboxyl-terminal hydrolase 27"
                     /protein_id="NP_001138545.1"
                     /db_xref="CCDS:CCDS65260.1"
                     /db_xref="GeneID:389856"
                     /db_xref="HGNC:HGNC:13486"
                     /db_xref="MIM:300975"
                     /translation="MCKDYVYDKDIEQIAKEEQGEALKLQASTSTEVSHQQCSVPGLG
                     EKFPTWETTKPELELLGHNPRRRRITSSFTIGLRGLINLGNTCFMNCIVQALTHTPIL
                     RDFFLSDRHRCEMPSPELCLVCEMSSLFRELYSGNPSPHVPYKLLHLVWIHARHLAGY
                     RQQDAHEFLIAALDVLHRHCKGDDVGKAANNPNHCNCIIDQIFTGGLQSDVTCQACHG
                     VSTTIDPCWDISLDLPGSCTSFWPMSPGRESSVNGESHIPGITTLTDCLRRFTRPEHL
                     GSSAKIKCGSCQSYQESTKQLTMNKLPVVACFHFKRFEHSAKQRRKITTYISFPLELD
                     MTPFMASSKESRMNGQLQLPTNSGNNENKYSLFAVVNHQGTLESGHYTSFIRHHKDQW
                     FKCDDAVITKASIKDVLDSEGYLLFYHKQVLEHESEKVKEMNTQAY"
     regulatory      3023..3028
                     /regulatory_class="polyA_signal_sequence"
                     /gene="USP27X"
                     /gene_synonym="MRX105; USP22L; USP27; XLID105"
                     /note="hexamer: AGTAAA"
     polyA_site      3043
                     /gene="USP27X"
                     /gene_synonym="MRX105; USP22L; USP27; XLID105"
                     /note="major polyA site"
     regulatory      3053..3058
                     /regulatory_class="polyA_signal_sequence"
                     /gene="USP27X"
                     /gene_synonym="MRX105; USP22L; USP27; XLID105"
                     /note="hexamer: AGTAAA"
     polyA_site      3075
                     /gene="USP27X"
                     /gene_synonym="MRX105; USP22L; USP27; XLID105"
                     /note="major polyA site"
ORIGIN      
        1 aggagccgcc gccagtggag gcggaggagg tagaggaggc ggagacggcg gagaaggcgg
       61 agaggaaggt ggaggcggag gcgaaggtgg aggggaaggc ggaggcggcg gggaaggcgg
      121 aggcggcggg gaaggtggac gccaccgaga aggtggagac ggcggggaag gtggacgccg
      181 ctgggaaggt ggagacggcg gagggtccgg gccgccgggc tgagctcaag ctggagcccg
      241 aacccgagcc ggtccgggag gcggagcagg agccgaagca ggagctggag gatgagaacc
      301 cagcgcggag cggcggtggc ggcaacagcg acgaggttcc tccccccacc cttccctccg
      361 atccaccgcg gccccccgat ccctctccgc gtcgcagtcg tgcgccgcgc cgccgacccc
      421 ggccccggcc ccagacccgg ctccgtaccc cgccgcagcc taggccccgg cccccgcccc
      481 ggccccggcc ccggcgcggc cctgggggcg gatgcctgga tgtggatttt gccgtggggc
      541 caccaggctg ttctcacgtg aacagcttta aggtgggaga gaactggagg caggaactgc
      601 gggttatcta ccagtgcttc gtgtggtgtg gaaccccaga gaccaggaaa agcaaggcaa
      661 agtcctgcat ctgccatgtg tgtggcaccc atctgaacag actccactct tgcctttcct
      721 gtgtcttctt tggctgcttc acggagaaac acattcacga gcacgcagag acgaaacaac
      781 acaacttagc agtagacctg tattacggag gtatatactg ctttatgtgt aaggactatg
      841 tatatgacaa agacattgag caaattgcca aagaagagca aggagaagct ttgaaattac
      901 aagcctccac ctcaacagag gtttctcacc agcagtgttc agtgccaggc cttggtgaga
      961 aattcccaac ctgggaaaca accaaaccag aattagaact gctggggcac aacccgagga
     1021 gaagaagaat cacctccagc tttacgatcg gtttaagagg actcatcaat cttggcaaca
     1081 cgtgctttat gaactgcatt gtccaggccc tcacccacac gccgatactg agagatttct
     1141 ttctctctga caggcaccga tgtgagatgc cgagtcccga gttgtgtctg gtctgtgaga
     1201 tgtcgtcgct gtttcgggag ttgtattctg gaaacccgtc tcctcatgtg ccctataagt
     1261 tactgcacct ggtgtggata catgcccgcc atttagcagg gtacaggcaa caggatgccc
     1321 acgagttcct cattgcagcg ttagatgtcc tgcacaggca ctgcaaaggt gatgatgtcg
     1381 ggaaggcggc caacaatccc aaccactgta actgcatcat agaccaaatc ttcacaggtg
     1441 gcctgcagtc tgatgtcacc tgtcaagcct gccatggcgt ctccaccacg atagacccat
     1501 gctgggacat tagtttggac ttgcctggct cttgcacctc cttctggccc atgagcccag
     1561 ggagggagag cagtgtgaac ggggaaagcc acataccagg aatcaccacc ctcacggact
     1621 gcttgcggag gtttacgagg ccagagcact taggaagcag tgccaaaatc aaatgtggta
     1681 gttgccaaag ctaccaggaa tctaccaaac agctcacaat gaataaatta cctgtcgttg
     1741 cctgttttca tttcaaacgg tttgaacatt cagcgaaaca gaggcgcaag atcactacat
     1801 acatttcctt tcctctggag ctggatatga cgccgtttat ggcctcaagt aaagagagca
     1861 gaatgaatgg acaattgcag ctgccaacca atagtggaaa caacgaaaat aagtattcct
     1921 tgtttgctgt ggttaatcac caaggaacct tggagagtgg ccactatacc agcttcatcc
     1981 ggcaccacaa ggaccagtgg ttcaagtgtg atgatgccgt catcactaag gccagtatta
     2041 aggacgtact ggacagtgaa gggtatttac tgttctatca caaacaggtg ctagaacatg
     2101 agtcagaaaa agtgaaagaa atgaacacac aagcctactg aagtgacaca cagacctacc
     2161 tgcaatggaa gatgacgaca ccaatactac aactggcatc gagatctaaa ggacctactt
     2221 gaccatggcc catgggcctg acagagtaag aattgaacag tacccagtgt ccaaaaggtc
     2281 ctgattggaa gagaaataga aggggaggga gaagaggctc tagtctaagc agttgatgaa
     2341 agggaaatta aatggtagaa acactctggg tgaggaaggc aggagcagga aaatgctgac
     2401 actggtacat atcctatatt cctccaaaag attgtgtggg aaagtgtggg ggggaggggg
     2461 gtggtggggg gggagtgtgc ccttgtaacc gtaaaacatc tttctccatg ggtgtttcag
     2521 cttcaattga ccaatcacat aacagttata tgtttggggg gaaaaagaaa agtttctaaa
     2581 aaatgtagcc cattacatat atgggtatga aagcagaaaa gtggaggagg cagggatatc
     2641 attgacaaac acctttgcca gtttctttgt attcgtgatt ttttgtgcta ttaaatgcag
     2701 tattaaaaca agaaaagccc acctgggcta gtgaaaggag aggaaataag ggggcttgta
     2761 aaaggggagc cgtcgctcca aaagtagaga agacaagaaa tgctgtaaga taagcaacca
     2821 acgcagacag gcctcagcta agagtatagt gtgtgtgtgt taaaaaaaaa aaaaaaaaaa
     2881 gaaaaaaaaa agctgtatga tatacttgag caaatcaatg aacctctttg cgattgtttt
     2941 atcatctgta aaatgcagat aattcctacc ttaaagggtt attgttaaag ataaaatgat
     3001 ataaaaatgt gtcaaagtat aaagtaaaag gcttggaact ttgtagggac tcagtaaacg
     3061 tttgttggat ccaaa
//
