LOCUS       NM_031907               5525 bp    mRNA    linear   PRI 12-NOV-2024
DEFINITION  Homo sapiens ubiquitin specific peptidase 26 (USP26), mRNA.
ACCESSION   NM_031907 XM_017029892
VERSION     NM_031907.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5525)
  AUTHORS   Ma,M., Yi,L., Pei,Y., Zhang,Q., Tong,C., Zhao,M., Chen,Y., Zhu,J.,
            Zhang,W., Yao,F., Yang,P. and Zhang,P.
  TITLE     USP26 as a hepatitis B virus-induced deubiquitinase primes
            hepatocellular carcinogenesis by epigenetic remodeling
  JOURNAL   Nat Commun 15 (1), 7856 (2024)
   PUBMED   39251623
  REMARK    GeneRIF: USP26 as a hepatitis B virus-induced deubiquitinase primes
            hepatocellular carcinogenesis by epigenetic remodeling.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5525)
  AUTHORS   Liu,J., Zhai,M., Chen,Y., Wei,Y., Li,F., Chen,Y., Duan,B., Xing,L.,
            Du,H., Jiang,M., Li,H. and Ren,G.
  TITLE     Acetylation-dependent deubiquitinase USP26 stabilizes BAG3 to
            promote breast cancer progression
  JOURNAL   Cancer Lett 597, 217005 (2024)
   PUBMED   38880224
  REMARK    GeneRIF: Acetylation-dependent deubiquitinase USP26 stabilizes BAG3
            to promote breast cancer progression.
REFERENCE   3  (bases 1 to 5525)
  AUTHORS   Ye,Y., Li,M., Pan,Q., Fang,X., Yang,H., Dong,B., Yang,J., Zheng,Y.,
            Zhang,R. and Liao,Z.
  TITLE     Machine learning-based classification of deubiquitinase USP26 and
            its cell proliferation inhibition through stabilizing KLF6 in
            cervical cancer
  JOURNAL   Comput Biol Med 168, 107745 (2024)
   PUBMED   38064851
  REMARK    GeneRIF: Machine learning-based classification of deubiquitinase
            USP26 and its cell proliferation inhibition through stabilizing
            KLF6 in cervical cancer.
REFERENCE   4  (bases 1 to 5525)
  AUTHORS   Segarra-Fas,A., Espejo-Serrano,C., Bustos,F., Zhou,H., Wang,F.,
            Toth,R., Macartney,T., Bach,I., Nardocci,G. and Findlay,G.M.
  TITLE     An RNF12-USP26 amplification loop drives germ cell specification
            and is disrupted by disease-associated mutations
  JOURNAL   Sci Signal 15 (742), eabm5995 (2022)
   PUBMED   35857630
  REMARK    GeneRIF: An RNF12-USP26 amplification loop drives germ cell
            specification and is disrupted by disease-associated mutations.
REFERENCE   5  (bases 1 to 5525)
  AUTHORS   Tang,J., Luo,Y. and Xiao,L.
  TITLE     USP26 promotes anaplastic thyroid cancer progression by stabilizing
            TAZ
  JOURNAL   Cell Death Dis 13 (4), 326 (2022)
   PUBMED   35397626
  REMARK    GeneRIF: USP26 promotes anaplastic thyroid cancer progression by
            stabilizing TAZ.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 5525)
  AUTHORS   Paduch,D.A., Mielnik,A. and Schlegel,P.N.
  TITLE     Novel mutations in testis-specific ubiquitin protease 26 gene may
            cause male infertility and hypogonadism
  JOURNAL   Reprod Biomed Online 10 (6), 747-754 (2005)
   PUBMED   15970005
  REMARK    GeneRIF: The USP26 gene may be of importance in male reproduction.
            Mutations in this gene may be associated with male infertility, and
            may negatively affect testicular function.
            GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   7  (bases 1 to 5525)
  AUTHORS   Ross,M.T., Grafham,D.V., Coffey,A.J., Scherer,S., McLay,K.,
            Muzny,D., Platzer,M., Howell,G.R., Burrows,C., Bird,C.P.,
            Frankish,A., Lovell,F.L., Howe,K.L., Ashurst,J.L., Fulton,R.S.,
            Sudbrak,R., Wen,G., Jones,M.C., Hurles,M.E., Andrews,T.D.,
            Scott,C.E., Searle,S., Ramser,J., Whittaker,A., Deadman,R.,
            Carter,N.P., Hunt,S.E., Chen,R., Cree,A., Gunaratne,P., Havlak,P.,
            Hodgson,A., Metzker,M.L., Richards,S., Scott,G., Steffen,D.,
            Sodergren,E., Wheeler,D.A., Worley,K.C., Ainscough,R.,
            Ambrose,K.D., Ansari-Lari,M.A., Aradhya,S., Ashwell,R.I.,
            Babbage,A.K., Bagguley,C.L., Ballabio,A., Banerjee,R., Barker,G.E.,
            Barlow,K.F., Barrett,I.P., Bates,K.N., Beare,D.M., Beasley,H.,
            Beasley,O., Beck,A., Bethel,G., Blechschmidt,K., Brady,N.,
            Bray-Allen,S., Bridgeman,A.M., Brown,A.J., Brown,M.J., Bonnin,D.,
            Bruford,E.A., Buhay,C., Burch,P., Burford,D., Burgess,J.,
            Burrill,W., Burton,J., Bye,J.M., Carder,C., Carrel,L., Chako,J.,
            Chapman,J.C., Chavez,D., Chen,E., Chen,G., Chen,Y., Chen,Z.,
            Chinault,C., Ciccodicola,A., Clark,S.Y., Clarke,G., Clee,C.M.,
            Clegg,S., Clerc-Blankenburg,K., Clifford,K., Cobley,V., Cole,C.G.,
            Conquer,J.S., Corby,N., Connor,R.E., David,R., Davies,J., Davis,C.,
            Davis,J., Delgado,O., Deshazo,D., Dhami,P., Ding,Y., Dinh,H.,
            Dodsworth,S., Draper,H., Dugan-Rocha,S., Dunham,A., Dunn,M.,
            Durbin,K.J., Dutta,I., Eades,T., Ellwood,M., Emery-Cohen,A.,
            Errington,H., Evans,K.L., Faulkner,L., Francis,F., Frankland,J.,
            Fraser,A.E., Galgoczy,P., Gilbert,J., Gill,R., Glockner,G.,
            Gregory,S.G., Gribble,S., Griffiths,C., Grocock,R., Gu,Y.,
            Gwilliam,R., Hamilton,C., Hart,E.A., Hawes,A., Heath,P.D.,
            Heitmann,K., Hennig,S., Hernandez,J., Hinzmann,B., Ho,S., Hoffs,M.,
            Howden,P.J., Huckle,E.J., Hume,J., Hunt,P.J., Hunt,A.R.,
            Isherwood,J., Jacob,L., Johnson,D., Jones,S., de Jong,P.J.,
            Joseph,S.S., Keenan,S., Kelly,S., Kershaw,J.K., Khan,Z.,
            Kioschis,P., Klages,S., Knights,A.J., Kosiura,A., Kovar-Smith,C.,
            Laird,G.K., Langford,C., Lawlor,S., Leversha,M., Lewis,L., Liu,W.,
            Lloyd,C., Lloyd,D.M., Loulseged,H., Loveland,J.E., Lovell,J.D.,
            Lozado,R., Lu,J., Lyne,R., Ma,J., Maheshwari,M., Matthews,L.H.,
            McDowall,J., McLaren,S., McMurray,A., Meidl,P., Meitinger,T.,
            Milne,S., Miner,G., Mistry,S.L., Morgan,M., Morris,S., Muller,I.,
            Mullikin,J.C., Nguyen,N., Nordsiek,G., Nyakatura,G., O'Dell,C.N.,
            Okwuonu,G., Palmer,S., Pandian,R., Parker,D., Parrish,J.,
            Pasternak,S., Patel,D., Pearce,A.V., Pearson,D.M., Pelan,S.E.,
            Perez,L., Porter,K.M., Ramsey,Y., Reichwald,K., Rhodes,S.,
            Ridler,K.A., Schlessinger,D., Schueler,M.G., Sehra,H.K.,
            Shaw-Smith,C., Shen,H., Sheridan,E.M., Shownkeen,R., Skuce,C.D.,
            Smith,M.L., Sotheran,E.C., Steingruber,H.E., Steward,C.A.,
            Storey,R., Swann,R.M., Swarbreck,D., Tabor,P.E., Taudien,S.,
            Taylor,T., Teague,B., Thomas,K., Thorpe,A., Timms,K., Tracey,A.,
            Trevanion,S., Tromans,A.C., d'Urso,M., Verduzco,D., Villasana,D.,
            Waldron,L., Wall,M., Wang,Q., Warren,J., Warry,G.L., Wei,X.,
            West,A., Whitehead,S.L., Whiteley,M.N., Wilkinson,J.E.,
            Willey,D.L., Williams,G., Williams,L., Williamson,A.,
            Williamson,H., Wilming,L., Woodmansey,R.L., Wray,P.W., Yen,J.,
            Zhang,J., Zhou,J., Zoghbi,H., Zorilla,S., Buck,D., Reinhardt,R.,
            Poustka,A., Rosenthal,A., Lehrach,H., Meindl,A., Minx,P.J.,
            Hillier,L.W., Willard,H.F., Wilson,R.K., Waterston,R.H., Rice,C.M.,
            Vaudin,M., Coulson,A., Nelson,D.L., Weinstock,G., Sulston,J.E.,
            Durbin,R., Hubbard,T., Gibbs,R.A., Beck,S., Rogers,J. and
            Bentley,D.R.
  TITLE     The DNA sequence of the human X chromosome
  JOURNAL   Nature 434 (7031), 325-337 (2005)
   PUBMED   15772651
REFERENCE   8  (bases 1 to 5525)
  AUTHORS   Stouffs,K., Lissens,W., Tournaye,H., Van Steirteghem,A. and
            Liebaers,I.
  TITLE     Possible role of USP26 in patients with severely impaired
            spermatogenesis
  JOURNAL   Eur J Hum Genet 13 (3), 336-340 (2005)
   PUBMED   15562280
  REMARK    GeneRIF: Alterations in the USP26 gene may be involved in male
            infertility or might increase the risk of male infertility.  These
            patients showed 370-371insACA, 494T>C and 1423C>T causing
            T123-124ins, L165S and H475Y, respectively
            GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   9  (bases 1 to 5525)
  AUTHORS   Puente,X.S., Sanchez,L.M., Overall,C.M. and Lopez-Otin,C.
  TITLE     Human and mouse proteases: a comparative genomic approach
  JOURNAL   Nat Rev Genet 4 (7), 544-558 (2003)
   PUBMED   12838346
  REMARK    Review article
REFERENCE   10 (bases 1 to 5525)
  AUTHORS   Wang,P.J., McCarrey,J.R., Yang,F. and Page,D.C.
  TITLE     An abundance of X-linked genes expressed in spermatogonia
  JOURNAL   Nat Genet 27 (4), 422-426 (2001)
   PUBMED   11279525
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from Z81365.2.
            This sequence is a reference standard in the RefSeqGene project.
            
            On or before Jan 6, 2021 this sequence version replaced
            XM_017029892.1, NM_031907.2.
            
            Summary: This gene encodes a member of the ubiquitin-specific
            processing (UBP) family of proteases and is a deubiquitinating
            enzyme (DUB) with His and Cys domains. It is specifically expressed
            in testis tissue. Mutations in this gene have been associated with
            Sertoli cell-only syndrome and male infertility. [provided by
            RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK292527.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1968968,
                                           SAMEA2148874 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000511190.6/ ENSP00000423390.1
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-80                Z81365.2           143629-143708       c
            81-171              Z81365.2           137952-138042       c
            172-217             Z81365.2           137317-137362       c
            218-331             Z81365.2           136712-136825       c
            332-396             Z81365.2           130306-130370       c
            397-5525            Z81365.2           69767-74895         c
FEATURES             Location/Qualifiers
     source          1..5525
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /map="Xq26.2"
     gene            1..5525
                     /gene="USP26"
                     /gene_synonym="SPGFX6"
                     /note="ubiquitin specific peptidase 26"
                     /db_xref="GeneID:83844"
                     /db_xref="HGNC:HGNC:13485"
                     /db_xref="MIM:300309"
     exon            1..80
                     /gene="USP26"
                     /gene_synonym="SPGFX6"
                     /inference="alignment:Splign:2.1.0"
     exon            81..171
                     /gene="USP26"
                     /gene_synonym="SPGFX6"
                     /inference="alignment:Splign:2.1.0"
     exon            172..217
                     /gene="USP26"
                     /gene_synonym="SPGFX6"
                     /inference="alignment:Splign:2.1.0"
     exon            218..331
                     /gene="USP26"
                     /gene_synonym="SPGFX6"
                     /inference="alignment:Splign:2.1.0"
     exon            332..396
                     /gene="USP26"
                     /gene_synonym="SPGFX6"
                     /inference="alignment:Splign:2.1.0"
     exon            397..5525
                     /gene="USP26"
                     /gene_synonym="SPGFX6"
                     /inference="alignment:Splign:2.1.0"
     CDS             473..3214
                     /gene="USP26"
                     /gene_synonym="SPGFX6"
                     /EC_number="3.4.19.12"
                     /note="ubiquitin specific protease 26; ubiquitin
                     thiolesterase 26; ubiquitin-specific processing protease
                     26; deubiquitinating enzyme 26; ubiquitin thioesterase 26"
                     /codon_start=1
                     /product="ubiquitin carboxyl-terminal hydrolase 26"
                     /protein_id="NP_114113.1"
                     /db_xref="CCDS:CCDS14635.1"
                     /db_xref="GeneID:83844"
                     /db_xref="HGNC:HGNC:13485"
                     /db_xref="MIM:300309"
                     /translation="MAALFLRGFVQIGNCKTGISKSKEAFIEAVERKKKDRLVLYFKS
                     GKYSTFRLSDNIQNVVLKSYRGNQNHLHLTLQNNNGLFIEGLSSTDAEQLKIFLDRVH
                     QNEVQPPVRPGKGGSVFSSTTQKEINKTSFHKVDEKSSSKSFEIAKGSGTGVLQRMPL
                     LTSKLTLTCGELSENQHKKRKRMLSSSSEMNEEFLKENNSVEYKKSKADCSRCVSYNR
                     EKQLKLKELEENKKLECESSCIMNATGNPYLDDIGLLQALTEKMVLVFLLQQGYSDGY
                     TKWDKLKLFFELFPEKICHGLPNLGNTCYMNAVLQSLLSIPSFADDLLNQSFPWGKIP
                     LNALTMCLARLLFFKDTYNIEIKEMLLLNLKKAISAAAEIFHGNAQNDAHEFLAHCLD
                     QLKDNMEKLNTIWKPKSEFGEDNFPKQVFADDPDTSGFSCPVITNFELELLHSIACKA
                     CGQVILKTELNNYLSINLPQRIKAHPSSIQSTFDLFFGAEELEYKCAKCEHKTSVGVH
                     SFSRLPRILIVHLKRYSLNEFCALKKNDQEVIISKYLKVSSHCNEGTRPPLPLSEDGE
                     ITDFQLLKVIRKMTSGNISVSWPATKESKDILAPHIGSDKESEQKKGQTVFKGASRRQ
                     QQKYLGKNSKPNELESVYSGDRAFIEKEPLAHLMTYLEDTSLCQFHKAGGKPASSPGT
                     PLSKVDFQTVPENPKRKKYVKTSKFVAFDRIINPTKDLYEDKNIRIPERFQKVSEQTQ
                     QCDGMRICEQAPQQALPQSFPKPGTQGHTKNLLRPTKLNLQKSNRNSLLALGSNKNPR
                     NKDILDKIKSKAKETKRNDDKGDHTYRLISVVSHLGKTLKSGHYICDAYDFEKQIWFT
                     YDDMRVLGIQEAQMQEDRRCTGYIFFYMHNEIFEEMLKREENAQLNSKEVEETLQKE"
     regulatory      5508..5513
                     /regulatory_class="polyA_signal_sequence"
                     /gene="USP26"
                     /gene_synonym="SPGFX6"
                     /note="hexamer: AATAAA"
     polyA_site      5525
                     /gene="USP26"
                     /gene_synonym="SPGFX6"
                     /note="major polyA site"
ORIGIN      
        1 ccattttgtt ttcgatcgtt aagtgggcac gtggtggagc gttggtgtgt caggggtgtc
       61 gacttcttcc acaaactatt taagagacag cagcaggagg gactggactg gattgtagaa
      121 aacttcaaga gttaaggagt gcggagtgct gctcaggtgc ctttgtttca ggtcatagtc
      181 tctgttctat atagcagcca accacaaggg ttgattgagt ctcactctgt tacccaagct
      241 ggagtgtagt gatgcaatca cagctcactg cagccttgac ctcctgaact caagtgatcc
      301 tcccacctca gcctcctaac tggggctaca gattccctgt ttctgcttta acctgggctg
      361 cttgctaagt gcttgcctct caggatcctt gtggagctga acttgcaaaa cagattggaa
      421 cttcaagatt atcaataatc ggagatacgt atattttatt tgtaaagaaa acatggctgc
      481 cctattccta cgtggttttg tccaaatagg gaactgcaag actgggatat ctaagtcaaa
      541 agaagcattc attgaagcag tggaaagaaa gaagaaagat agactggtgc tgtatttcaa
      601 aagtggaaaa tatagcactt ttcggctaag tgataatatt caaaatgtag tccttaaatc
      661 ctatagagga aaccaaaatc acctgcattt aactttacaa aataataatg gcttgtttat
      721 tgaaggatta tcctccacag atgctgaaca attgaagata ttcttggaca gagttcatca
      781 aaacgaggtt cagccacctg tgagacctgg taagggtggg agtgtctttt ctagcacaac
      841 acagaaggaa atcaacaaaa cttcattcca caaagttgat gagaaatcaa gtagcaaatc
      901 ttttgagata gcaaaaggaa gtgggacagg tgtccttcag aggatgcctt tgcttacatc
      961 aaaattgaca cttacttgcg gagagttatc agaaaatcag cacaagaaga ggaaaagaat
     1021 gctctcatct agctcagaga tgaatgagga attcttgaaa gaaaataatt ctgtagaata
     1081 caagaaatcc aaggcagatt gttcgaggtg tgtaagctat aatcgagaga aacaattgaa
     1141 gttaaaagag ttagaagaga ataagaaatt ggaatgtgaa tcttcatgca tcatgaacgc
     1201 cactggaaat ccttacctag atgacattgg tcttctccaa gctctcactg agaaaatggt
     1261 tttggtattt ctgttacaac aagggtatag tgacggttac acaaagtggg ataaattaaa
     1321 actatttttt gaattatttc cagagaaaat atgccacggc ctccccaatt tgggaaacac
     1381 ctgttatatg aatgcagtgt tacagtctct actttcaatc ccatcgtttg ctgatgattt
     1441 acttaatcag agtttcccat ggggtaaaat tccccttaat gctcttacca tgtgcttggc
     1501 acggctactt ttttttaaag atacctataa tatagaaatc aaggagatgt tactcttgaa
     1561 tcttaaaaag gccatttcag cagctgcaga gatattccat ggcaatgcac agaacgatgc
     1621 tcatgagttt ttagctcact gtttagatca actgaaagat aacatggaaa aactcaacac
     1681 aatttggaag cctaaaagtg aatttgggga agataatttt cctaaacagg tttttgctga
     1741 tgatcctgac accagtgggt tttcttgccc tgtcattact aattttgagt tagagttgtt
     1801 gcactccatt gcttgtaaag cttgtggtca ggttattctc aagacagaac tgaataatta
     1861 cctctccatc aaccttcccc aaagaataaa agcacatcct tcatctattc agtctacttt
     1921 tgatcttttt tttggagcag aagagcttga gtataaatgt gcaaaatgtg agcacaagac
     1981 ttccgttgga gtgcactcat tcagtaggct acctagaatc cttattgttc acctcaaacg
     2041 ctatagcttg aatgagtttt gtgcattaaa gaagaatgac caggaagtca tcatttccaa
     2101 atatttaaag gtgtcttctc attgcaatga aggcaccaga ccacctcttc ccttgagtga
     2161 ggatggagaa attacagatt tccaattatt aaaagttatt cgaaagatga cttctggaaa
     2221 catcagtgta tcatggcctg caacaaagga atccaaagat atcctggctc cacacattgg
     2281 atcagataag gagtctgaac aaaaaaaagg ccagacagtc tttaaagggg caagcagaag
     2341 acagcagcaa aagtaccttg gaaaaaattc taaaccaaat gagctagaat ctgtatactc
     2401 aggagatcga gcattcattg aaaaagaacc gttagctcac ttaatgacgt atctggaaga
     2461 tacctcactt tgtcagttcc acaaagctgg aggtaaacct gccagcagcc caggcacacc
     2521 tctctcaaaa gttgactttc aaacagtgcc cgaaaatcca aaacgaaaga aatatgtgaa
     2581 aaccagtaag tttgtagctt ttgataggat tatcaatcct actaaagatt tgtatgaaga
     2641 taaaaatatc agaattccag aaagattcca aaaagtgtct gaacagactc agcagtgtga
     2701 cggtatgaga atctgtgaac aagcccctca gcaggcactg cctcaaagct ttccaaagcc
     2761 aggcacccag gggcacacaa agaacctcct aagacctaca aaattaaatc tacagaagtc
     2821 taacaggaat tccctacttg cactgggttc caataagaat ccaagaaaca aagacatttt
     2881 agataagata aaatctaaag ccaaggaaac aaaaagaaat gatgataagg gagatcatac
     2941 ctaccggctc attagtgttg tcagccatct tgggaagact ctaaagtcag gccattatat
     3001 ctgtgatgcc tatgactttg agaaacagat ctggttcact tacgatgata tgcgggtgtt
     3061 aggtatccag gaggcccaga tgcaggagga taggcgttgc actgggtaca tcttctttta
     3121 catgcataat gagatctttg aagagatgtt gaaaagagaa gagaatgccc agcttaatag
     3181 caaggaggta gaggagaccc ttcagaagga ataagaggaa cgtactcctc cttgtacaga
     3241 tctgcctgac tgtctcactc gataccactt cctccatgga aggaaaactg tgaactttat
     3301 ccagagatga aaatgcaatt agtctaggac caaaggtcaa acagaaacac ttaatgggga
     3361 gatctgcatt ctaatcctga cacagacacc tcaatcccat agctctggct gatgagcatc
     3421 cttctctcct acaagactga aattgtgttt ttcatgttct tcttcatttt aatatagtca
     3481 gggtcttgct ctgtcatcct ggctagagtg cagtccttca ataataactc actgcagcct
     3541 caaactcctg gcatcaagcg attctctctc agcctcctga aaagagaggg acttatcttc
     3601 ttgcttgaga tgggactata gatgtgtgcc accaggccta gctatttttt tttttttttt
     3661 tgctttttgc agagacaggg tctcactatg ctgcccaggt tggacttgaa ctcctggcct
     3721 caagcaatct tcctgcctct ttccatgttc taatacagtg gtttaaaaag tatgctcctt
     3781 aaactagcag caccaggagc atgggggtag tcatttgaaa tgcaaaatct tgggttccac
     3841 tgtagaccta ctgattcaga aacttggggt aagggatagc aatctgatgg agaccgtgat
     3901 gcttgataca gtttgagaac cactactgta ctacatacac taccttggtt gtatatttaa
     3961 attgcttatt ttgtaaaagg ttttgattac atttttgtgt ttttcatatt aatgtatgcc
     4021 ttgcctttgt gaacttatta aaagccaaac tcacaaaaat cacttctgat catactctgc
     4081 aatttggtgg aaaaaaatag ttgctgggat cctggcaata aaaaatgagg ctgataactt
     4141 ttgaatcctc ttgggcatat atagatgagg ctaaacgcca agtcaaatct ccagattgat
     4201 ttgcttttaa gaaattggcc cacatttcct gtgtgtctgc tagcaagctc ttggcccttg
     4261 gtggtctgag cccaccttgc catgttagtt ttcttagagg ggcactttca ttgcctcaga
     4321 ggaactttgt ttacctggac ttcatctgcg aaaccttgaa caatcctctg cattcaacat
     4381 tacatgacta attccagatt tttttttttt ttttacatct ctgtacctta tagtgtggtg
     4441 gtcttgtttc ttcaatgagt aagcaatata tgctttaaag tggacttgta gaatttgaaa
     4501 gtattacttg ttacttattt gacacaacat cagaaactcc atatgaagat gttctgcttc
     4561 tggggaaaga tgcatggatc ctagggtggt catatttcat taaaatccag gggatttaat
     4621 aattttgcca tcaagcatgt gccaccacta ttatcataac cttttcctgc ctttgaggca
     4681 gtgaatctgt tgtactttgt gcctttgctg tgaacaaatg acttgtacta agaggttttc
     4741 tcacataaca taggattgaa ttttcagtca cacctttacc aataggaata tgcccccttg
     4801 tatatggggt atggcttcag tatagttgta ttaatccaag agcttgttga tgctcttaag
     4861 cctagggtcc tttaaaatag gtgagttgga ttttagtgat gtggggaagt tattagtagg
     4921 taataccctg taagaggaaa accagattcc aaagtttgga gattgtattc agaacacagt
     4981 ttatctagaa ggaggtctta tgagacctga agattgctaa ggtatatagg agggaatatc
     5041 atagattgaa ttgatcactc ttagggaaga aggtgttaca gacacaatga gtgattgttc
     5101 aacttctgta gtacttcagc agctgaagga taaggctgga gttgcattta gaggagagtg
     5161 acagtttggt ttctaaattt cagttttttg gcctctagag tagtttatgt tgagcccagt
     5221 tacatagata tcagaacagg attttggtaa gaatgaagga aagttgtttt gttttgaaag
     5281 gagtgtgaag atgctaataa cttgatattt tagtacagag tttacatcct ggtcatgctg
     5341 ctcttcagca tgtagcactt ccaaatgcag ggcaaaatga aatgtgaaga agatggtagg
     5401 ggtatccatg acagggagga tcatggctgc aatccattgt tgccctgtga gaagaaattc
     5461 tgaatgcact atgaatgctt gtatagtatc tacatggtat gttttcaaat aaaagattaa
     5521 aagtt
//
