LOCUS       NM_001283041            5379 bp    mRNA    linear   PRI 19-JAN-2025
DEFINITION  Homo sapiens ubiquitin specific peptidase 25 (USP25), transcript
            variant 1, mRNA.
ACCESSION   NM_001283041 XM_005260946
VERSION     NM_001283041.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5379)
  AUTHORS   Fan,C.X., Liu,X.R., Mei,D.Q., Li,B.M., Li,W.B., Xie,H.C., Wang,J.,
            Shen,N.X., Ye,Z.L., You,Q.L., Li,L.Y., Qu,X.C., Chen,L.Z.,
            Liang,J.J., Zhang,M.R., He,N., Li,J., Gao,J.Y., Deng,W.Y.,
            Liu,W.Z., Wang,W.T., Liao,W.P., Chen,Q. and Shi,Y.W.
  TITLE     Heterozygous variants in USP25 cause genetic generalized epilepsy
  JOURNAL   Brain 147 (10), 3442-3457 (2024)
   PUBMED   38875478
  REMARK    GeneRIF: Heterozygous variants in USP25 cause genetic generalized
            epilepsy.
REFERENCE   2  (bases 1 to 5379)
  AUTHORS   Jiang,P., Jing,Y., Zhao,S., Lan,C., Yang,L., Dai,X., Luo,L.,
            Cai,S., Zhu,Y., Miller,H., Lai,J., Zhang,X., Zhao,X., Wu,Y.,
            Yang,J., Zhang,W., Guan,F., Zhong,B., Umehara,H., Lei,J., Dong,L.
            and Liu,C.
  TITLE     Expression of USP25 associates with fibrosis, inflammation and
            metabolism changes in IgG4-related disease
  JOURNAL   Nat Commun 15 (1), 2627 (2024)
   PUBMED   38521787
  REMARK    GeneRIF: Expression of USP25 associates with fibrosis, inflammation
            and metabolism changes in IgG4-related disease.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5379)
  AUTHORS   Teo,Q.W., Wong,H.H., Heunis,T., Stancheva,V., Hachim,A., Lv,H.,
            Siu,L., Ho,J., Lan,Y., Mok,C.K.P., Ulferts,R. and Sanyal,S.
  TITLE     Usp25-Erlin1/2 activity limits cholesterol flux to restrict virus
            infection
  JOURNAL   Dev Cell 58 (22), 2495-2509 (2023)
   PUBMED   37683630
  REMARK    GeneRIF: Usp25-Erlin1/2 activity limits cholesterol flux to
            restrict virus infection.
REFERENCE   4  (bases 1 to 5379)
  AUTHORS   Liu,Y., Ma,J., Lu,S., He,P. and Dong,W.
  TITLE     USP25 promotes hepatocellular carcinoma progression by interacting
            with TRIM21 via the Wnt/beta-catenin signaling pathway
  JOURNAL   Chin Med J (Engl) 136 (18), 2229-2242 (2023)
   PUBMED   37439386
  REMARK    GeneRIF: USP25 promotes hepatocellular carcinoma progression by
            interacting with TRIM21 via the Wnt/beta-catenin signaling pathway.
REFERENCE   5  (bases 1 to 5379)
  AUTHORS   Yamada,H., Yanagisawa,K., Tokumaru,S., Taguchi,A., Nimura,Y.,
            Osada,H., Nagino,M. and Takahashi,T.
  TITLE     Detailed characterization of a homozygously deleted region
            corresponding to a candidate tumor suppressor locus at 21q11-21 in
            human lung cancer
  JOURNAL   Genes Chromosomes Cancer 47 (9), 810-818 (2008)
   PUBMED   18523997
  REMARK    GeneRIF: downregulation of USP25 gene in human lung cancer
REFERENCE   6  (bases 1 to 5379)
  AUTHORS   Bosch-Comas,A., Lindsten,K., Gonzalez-Duarte,R., Masucci,M.G. and
            Marfany,G.
  TITLE     The ubiquitin-specific protease USP25 interacts with three
            sarcomeric proteins
  JOURNAL   Cell Mol Life Sci 63 (6), 723-734 (2006)
   PUBMED   16501887
REFERENCE   7  (bases 1 to 5379)
  AUTHORS   Valero,R., Bayes,M., Francisca Sanchez-Font,M., Gonzalez-Angulo,O.,
            Gonzalez-Duarte,R. and Marfany,G.
  TITLE     Characterization of alternatively spliced products and
            tissue-specific isoforms of USP28 and USP25
  JOURNAL   Genome Biol 2 (10), RESEARCH0043 (2001)
   PUBMED   11597335
  REMARK    GeneRIF: characterization of alternatively spliced products and
            tissue-specific isoforms
REFERENCE   8  (bases 1 to 5379)
  AUTHORS   Groet,J., Ives,J.H., Jones,T.A., Danton,M., Flomen,R.H., Sheer,D.,
            Hrascan,R., Pavelic,K. and Nizetic,D.
  TITLE     Narrowing of the region of allelic loss in 21q11-21 in squamous
            non-small cell lung carcinoma and cloning of a novel
            ubiquitin-specific protease gene from the deleted segment
  JOURNAL   Genes Chromosomes Cancer 27 (2), 153-161 (2000)
   PUBMED   10612803
REFERENCE   9  (bases 1 to 5379)
  AUTHORS   Valero,R., Marfany,G., Gonzalez-Angulo,O., Gonzalez-Gonzalez,G.,
            Puelles,L. and Gonzalez-Duarte,R.
  TITLE     USP25, a novel gene encoding a deubiquitinating enzyme, is located
            in the gene-poor region 21q11.2
  JOURNAL   Genomics 62 (3), 395-405 (1999)
   PUBMED   10644437
REFERENCE   10 (bases 1 to 5379)
  AUTHORS   Garfunkel,J.M., Ulshen,M.H., Hamrick,H.J. and Lawson,E.E.
  TITLE     Problems identified by secondary review of accepted manuscripts
  JOURNAL   JAMA 263 (10), 1369-1371 (1990)
   PUBMED   2304215
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AJ010597.1, BC075792.1, FJ763652.1, AJ010598.1 and BM149594.1.
            
            On Aug 14, 2020 this sequence version replaced NM_001283041.2.
            
            Summary: Ubiquitin (MIM 191339) is a highly conserved 76-amino acid
            protein involved in regulation of intracellular protein breakdown,
            cell cycle regulation, and stress response. Ubiquitin is released
            from degraded proteins by disassembly of the polyubiquitin chains,
            which is mediated by ubiquitin-specific proteases (USPs), such as
            USP25 (Valero et al., 1999 [PubMed 10644437]).[supplied by OMIM,
            Mar 2008].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (USP25m).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FJ763652.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2146982, SAMEA2147975
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000400183.7/ ENSP00000383044.2
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-43                AJ010597.1         19226-19268
            44-412              BC075792.1         2-370
            413-2041            FJ763652.1         1-1629
            2042-2042           AJ010598.1         22435-22435
            2043-3790           FJ763652.1         1631-3378
            3791-5377           AJ010598.1         73771-75357
            5378-5379           BM149594.1         44-45               c
FEATURES             Location/Qualifiers
     source          1..5379
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="21"
                     /map="21q21.1"
     gene            1..5379
                     /gene="USP25"
                     /gene_synonym="EIG19; USP21"
                     /note="ubiquitin specific peptidase 25"
                     /db_xref="GeneID:29761"
                     /db_xref="HGNC:HGNC:12624"
                     /db_xref="MIM:604736"
     exon            1..457
                     /gene="USP25"
                     /gene_synonym="EIG19; USP21"
                     /inference="alignment:Splign:2.1.0"
     CDS             413..3790
                     /gene="USP25"
                     /gene_synonym="EIG19; USP21"
                     /EC_number="3.4.19.12"
                     /note="isoform USP25m is encoded by transcript variant 1;
                     ubiquitin carboxyl-terminal hydrolase 25; ubiquitin
                     thiolesterase 25; deubiquitinating enzyme 25;
                     ubiquitin-specific processing protease 25; USP on
                     chromosome 21; ubiquitin thioesterase 25"
                     /codon_start=1
                     /product="ubiquitin carboxyl-terminal hydrolase 25 isoform
                     USP25m"
                     /protein_id="NP_001269970.1"
                     /db_xref="CCDS:CCDS63336.1"
                     /db_xref="GeneID:29761"
                     /db_xref="HGNC:HGNC:12624"
                     /db_xref="MIM:604736"
                     /translation="MTVEQNVLQQSAAQKHQQTFLNQLREITGINDTQILQQALKDSN
                     GNLELAVAFLTAKNAKTPQQEETTYYQTALPGNDRYISVGSQADTNVIDLTGDDKDDL
                     QRAIALSLAESNRAFRETGITDEEQAISRVLEASIAENKACLKRTPTEVWRDSRNPYD
                     RKRQDKAPVGLKNVGNTCWFSAVIQSLFNLLEFRRLVLNYKPPSNAQDLPRNQKEHRN
                     LPFMRELRYLFALLVGTKRKYVDPSRAVEILKDAFKSNDSQQQDVSEFTHKLLDWLED
                     AFQMKAEEETDEEKPKNPMVELFYGRFLAVGVLEGKKFENTEMFGQYPLQVNGFKDLH
                     ECLEAAMIEGEIESLHSENSGKSGQEHWFTELPPVLTFELSRFEFNQALGRPEKIHNK
                     LEFPQVLYLDRYMHRNREITRIKREEIKRLKDYLTVLQQRLERYLSYGSGPKRFPLVD
                     VLQYALEFASSKPVCTSPVDDIDASSPPSGSIPSQTLPSTTEQQGALSSELPSTSPSS
                     VAAISSRSVIHKPFTQSRIPPDLPMHPAPRHITEEELSVLESCLHRWRTEIENDTRDL
                     QESISRIHRTIELMYSDKSMIQVPYRLHAVLVHEGQANAGHYWAYIFDHRESRWMKYN
                     DIAVTKSSWEELVRDSFGGYRNASAYCLMYINDKAQFLIQEEFNKETGQPLVGIETLP
                     PDLRDFVEEDNQRFEKELEEWDAQLAQKALQEKLLASQKLRESETSVTTAQAAGDPEY
                     LEQPSRSDFSKHLKEETIQIITKASHEHEDKSPETVLQSKPENTTSQPLSNQRVVEVA
                     IPHVGKFMIESKEGGYDDEIMMTPNMQGIIMAIGKSRSVYDRCGPEAGFFKAIKLEYA
                     RLVKLAQEDTPPETDYRLHHVVVYFIQNQAPKKIIEKTLLEQFGDRNLSFDERCHNIM
                     KVAQAKLEMIKPEEVNLEEYEEWHQDYRKFRETTMYLIIGLENFQRESYIDSLLFLIC
                     AYQNNKELLSKGLYRGHDEELISHYRRECLLKLNEQAAELFESGEDREVNNGLIIMNE
                     FIVPFLPLLLVDEMEEKDILAVEDMRNRWCSYLGQEMEPHLQEKLTDFLPKLLDCSME
                     IKSFHEPPKLPSYSTHELCERFARIMLSLSRTPADGR"
     exon            458..535
                     /gene="USP25"
                     /gene_synonym="EIG19; USP21"
                     /inference="alignment:Splign:2.1.0"
     exon            536..680
                     /gene="USP25"
                     /gene_synonym="EIG19; USP21"
                     /inference="alignment:Splign:2.1.0"
     exon            681..804
                     /gene="USP25"
                     /gene_synonym="EIG19; USP21"
                     /inference="alignment:Splign:2.1.0"
     exon            805..967
                     /gene="USP25"
                     /gene_synonym="EIG19; USP21"
                     /inference="alignment:Splign:2.1.0"
     exon            968..1054
                     /gene="USP25"
                     /gene_synonym="EIG19; USP21"
                     /inference="alignment:Splign:2.1.0"
     exon            1055..1192
                     /gene="USP25"
                     /gene_synonym="EIG19; USP21"
                     /inference="alignment:Splign:2.1.0"
     exon            1193..1269
                     /gene="USP25"
                     /gene_synonym="EIG19; USP21"
                     /inference="alignment:Splign:2.1.0"
     exon            1270..1343
                     /gene="USP25"
                     /gene_synonym="EIG19; USP21"
                     /inference="alignment:Splign:2.1.0"
     exon            1344..1492
                     /gene="USP25"
                     /gene_synonym="EIG19; USP21"
                     /inference="alignment:Splign:2.1.0"
     exon            1493..1620
                     /gene="USP25"
                     /gene_synonym="EIG19; USP21"
                     /inference="alignment:Splign:2.1.0"
     exon            1621..1716
                     /gene="USP25"
                     /gene_synonym="EIG19; USP21"
                     /inference="alignment:Splign:2.1.0"
     exon            1717..1878
                     /gene="USP25"
                     /gene_synonym="EIG19; USP21"
                     /inference="alignment:Splign:2.1.0"
     exon            1879..2105
                     /gene="USP25"
                     /gene_synonym="EIG19; USP21"
                     /inference="alignment:Splign:2.1.0"
     exon            2106..2176
                     /gene="USP25"
                     /gene_synonym="EIG19; USP21"
                     /inference="alignment:Splign:2.1.0"
     exon            2177..2405
                     /gene="USP25"
                     /gene_synonym="EIG19; USP21"
                     /inference="alignment:Splign:2.1.0"
     exon            2406..2606
                     /gene="USP25"
                     /gene_synonym="EIG19; USP21"
                     /inference="alignment:Splign:2.1.0"
     exon            2607..2749
                     /gene="USP25"
                     /gene_synonym="EIG19; USP21"
                     /inference="alignment:Splign:2.1.0"
     exon            2750..2863
                     /gene="USP25"
                     /gene_synonym="EIG19; USP21"
                     /inference="alignment:Splign:2.1.0"
     exon            2864..2959
                     /gene="USP25"
                     /gene_synonym="EIG19; USP21"
                     /inference="alignment:Splign:2.1.0"
     exon            2960..3138
                     /gene="USP25"
                     /gene_synonym="EIG19; USP21"
                     /inference="alignment:Splign:2.1.0"
     exon            3139..3217
                     /gene="USP25"
                     /gene_synonym="EIG19; USP21"
                     /inference="alignment:Splign:2.1.0"
     exon            3218..3297
                     /gene="USP25"
                     /gene_synonym="EIG19; USP21"
                     /inference="alignment:Splign:2.1.0"
     exon            3298..3421
                     /gene="USP25"
                     /gene_synonym="EIG19; USP21"
                     /inference="alignment:Splign:2.1.0"
     exon            3422..3617
                     /gene="USP25"
                     /gene_synonym="EIG19; USP21"
                     /inference="alignment:Splign:2.1.0"
     exon            3618..5379
                     /gene="USP25"
                     /gene_synonym="EIG19; USP21"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4201..4206
                     /regulatory_class="polyA_signal_sequence"
                     /gene="USP25"
                     /gene_synonym="EIG19; USP21"
                     /note="hexamer: AATAAA"
     polyA_site      4222
                     /gene="USP25"
                     /gene_synonym="EIG19; USP21"
                     /note="major polyA site"
     regulatory      5006..5011
                     /regulatory_class="polyA_signal_sequence"
                     /gene="USP25"
                     /gene_synonym="EIG19; USP21"
                     /note="hexamer: AGTAAA"
     polyA_site      5027
                     /gene="USP25"
                     /gene_synonym="EIG19; USP21"
     regulatory      5342..5347
                     /regulatory_class="polyA_signal_sequence"
                     /gene="USP25"
                     /gene_synonym="EIG19; USP21"
                     /note="hexamer: AAGAAA"
     polyA_site      5379
                     /gene="USP25"
                     /gene_synonym="EIG19; USP21"
ORIGIN      
        1 attccgggcg gccgctccct ccgtcccctc tctcccttcc ccaaagcagc ccgcggaccg
       61 gcagcaaagg aacgtgcgaa cgcgtgacgc cgcccgactg gctcgcgctc tcccgtgccc
      121 cggcgtcctc cgcccgctca tggcccgggc cgccgcggac gagcggcgct gaggcgggcc
      181 gcgtggagac gtgaggcggc cgccgtggcc ctcacagtcg gcgtttcgcc gcctgcccgc
      241 ggtgcccgcg cacgccggcc gccatcgcct tcgcgcctgg ctggcggggg cgctgtcctc
      301 ccaggccgtc cgcgccgctc cctggagctc ggcggagcgc ggcagccagg gccggcggag
      361 gcgcgaggag ccgggcgcca ccgccgccgc cgccgccgcc gccgcggggg ccatgaccgt
      421 ggagcagaac gtgctgcagc agagcgcggc gcagaagcac cagcagacgt ttttgaatca
      481 actgagagaa attacgggga ttaatgacac ccagatacta cagcaagcct tgaaggatag
      541 taatggaaac ttggaattag cagtggcttt ccttactgcg aagaatgcta agacccctca
      601 gcaggaggag acaacttact accaaacagc acttcctggc aatgatagat acatcagtgt
      661 gggaagccaa gcagatacaa atgtgattga tctcactgga gatgataaag atgatcttca
      721 gagagcaatt gccttgagtt tggccgaatc aaacagggca ttcagggaga ctggaataac
      781 tgatgaggaa caagccatta gcagagttct tgaagccagc atagcagaga ataaagcatg
      841 tttgaagagg acacctacag aagtttggag ggattctcga aacccttatg atagaaaaag
      901 acaggacaaa gctcccgttg ggctaaagaa tgttggcaat acttgttggt ttagtgctgt
      961 tattcagtca ttatttaatc ttttggaatt tagaagatta gttctgaatt acaagcctcc
     1021 atcaaatgct caagatttac cccgaaacca aaaggaacat cggaatttgc cttttatgcg
     1081 tgagctgagg tatctatttg cacttcttgt tggtaccaaa aggaagtatg ttgatccatc
     1141 aagagcagtt gaaattctta aggatgcttt caaatcaaat gactcacagc agcaagatgt
     1201 gagtgagttt acacacaaat tattagattg gttagaagat gccttccaaa tgaaagctga
     1261 agaggagacg gatgaagaga agccaaagaa ccccatggta gagttgttct atggcagatt
     1321 cctggctgtg ggagtacttg aaggtaaaaa atttgaaaac actgaaatgt ttggtcagta
     1381 cccacttcag gtcaatgggt tcaaagatct gcatgagtgc ctagaagctg caatgattga
     1441 aggagaaatt gagtctttac attcagagaa ttcaggaaaa tcaggccaag agcattggtt
     1501 tactgaatta ccacctgtgt taacatttga attgtcaaga tttgaattta atcaggcatt
     1561 gggaagacca gaaaaaattc acaacaaatt agaatttccc caagttttat atttggacag
     1621 atacatgcac agaaacagag aaataacaag aattaagagg gaagagatca agagactgaa
     1681 agattacctc acggtattac aacaaaggct agaaagatat ttaagctatg gttccggtcc
     1741 caaacgattc cccttggtag atgttcttca gtatgcattg gaatttgcct caagtaaacc
     1801 tgtttgcact tctcctgttg acgatattga cgctagttcc ccacctagtg gttccatacc
     1861 atcacagaca ttaccaagca caacagaaca acagggagcc ctatcttcag aactgccaag
     1921 cacatcacct tcatcagttg ctgccatttc atcgagatca gtaatacaca aaccatttac
     1981 tcagtcccgg atacctccag atttgcccat gcatccggca ccaaggcaca taacggagga
     2041 agaactttct gtgctggaaa gttgtttaca tcgctggagg acagaaatag aaaatgacac
     2101 cagagatttg caggaaagca tatccagaat ccatcgaaca attgaattaa tgtactctga
     2161 caaatctatg atacaagttc cttatcgatt acatgccgtt ttagttcacg aaggccaagc
     2221 taatgctggg cactactggg catatatttt tgatcatcgt gaaagcagat ggatgaagta
     2281 caatgatatt gctgtgacaa aatcatcatg ggaagagcta gtgagggact cttttggtgg
     2341 ttatagaaat gccagtgcat actgtttaat gtacataaat gataaggcac agttcctaat
     2401 acaagaggag tttaataaag aaactgggca gccccttgtt ggtatagaaa cattaccacc
     2461 ggatttgaga gattttgttg aggaagacaa ccaacgattt gaaaaagaac tagaagaatg
     2521 ggatgcacaa cttgcccaga aagctttgca ggaaaagctt ttagcgtctc agaaattgag
     2581 agagtcagag acttctgtga caacagcaca agcagcagga gacccagaat atctagagca
     2641 gccatcaaga agtgatttct caaagcactt gaaagaagaa actattcaaa taattaccaa
     2701 ggcatcacat gagcatgaag ataaaagtcc tgaaacagtt ttgcagtcga aacctgaaaa
     2761 tactacaagc caaccacttt ctaatcagcg agttgtagag gtggcgatcc ctcatgtagg
     2821 gaaatttatg attgaatcaa aggagggggg gtatgatgac gagatcatga tgacaccgaa
     2881 catgcaaggt attatcatgg cgataggtaa atccaggagt gtatatgaca ggtgtggccc
     2941 tgaagcaggg ttctttaagg caattaagtt ggaatatgca aggttggtta agttggccca
     3001 agaagacacc ccaccagaaa ccgattatcg tttacatcat gtagtggtct actttatcca
     3061 gaaccaggca ccaaagaaaa ttattgagaa aacattacta gaacaatttg gagatagaaa
     3121 tttgagtttt gatgaaaggt gtcacaacat aatgaaagtt gctcaagcca aactggaaat
     3181 gataaaacct gaagaagtaa acttggagga atatgaggag tggcatcagg attataggaa
     3241 attcagggaa acaactatgt atctcataat tgggctagaa aattttcaaa gagaaagtta
     3301 tatagattcc ttgctgttcc tcatctgtgc ttatcagaat aacaaagaac tcttgtctaa
     3361 aggcttatac agaggacatg atgaagaatt gatatcacat tatagaagag aatgtttgct
     3421 aaaattaaat gagcaagccg cagaactctt cgaatctgga gaggatcgag aagtaaacaa
     3481 tggtttgatt atcatgaatg agtttattgt cccatttttg ccattattac tggtggatga
     3541 aatggaagaa aaggatatac tagctgtaga agatatgaga aatcgatggt gttcctacct
     3601 tggtcaagaa atggaaccac acctccaaga aaagctgaca gattttttgc caaaactgct
     3661 tgattgttct atggagatta aaagtttcca tgagccaccg aagttacctt catattccac
     3721 gcatgaactc tgtgagcgat ttgcccgaat catgttgtcc ctcagtcgaa ctcctgctga
     3781 tggaagataa actgcacact ttccctgaac acactgtata aactcttttt agttcttaac
     3841 ccttgccttc ctgtcacagg gtttgcttgt tgctgctata gtttttaact tttttttatt
     3901 ttaataactg caaaagacaa aatgactata cagactttag tcagactgca gacaataaag
     3961 ctgaaaatcg catggcgctc agacatttta accggaactg atgtataatc acaaatctaa
     4021 ttgattttat tatggcaaaa ctatgctttt gccaccttcc tgttgcagta ttactttgct
     4081 tttatctttt ctttctcaac agctttccat tcagtctgga tccttccatg actacagcca
     4141 tttaagtgtt cagcactgtg tacgatacat aatatttggt agcttgtaaa tgaaataaag
     4201 aataaagttt tatttatggc tacctatgtg tttgtaagca ggtatattgt atattagtgt
     4261 attagtaata ctagataaat gaattttgtc tggggattaa gattggatag ttaatagatt
     4321 aatacaatct tttaattctg ctctaatgct agcaaattgg aaaatgttta agtctttgac
     4381 acttaaattt atctatattt ttaacaaagt tcttgaactt agtatggcac cggaacctgt
     4441 tttgaattca gtcaggtttt tactcaagta agtggttgat tttttttaag tcaaactaca
     4501 ctgaaacttt tatccttttc ttagattaat cttacttttt aaatgtattt acaatataca
     4561 gcaaggtgat tatttcaaga gaatcccaaa gtacttgaat aagggctatt gtaaaattta
     4621 aaagaaatat ttatatatac acatatatac acatacacac atgtatatat atattcttca
     4681 taatggagga caatgttttg caatatataa atcattctat ttttgtaaat tgtatatcac
     4741 tttaattgaa aatgttctct actaattaat actgtgaaac aaaattgatg ttgtttaact
     4801 agaagttatg agtatcttaa ctgcctttat tccttttcaa aaaggaaaaa gctgtagaac
     4861 attttgtaga tgaaactact gtttaagatt aatgaattaa tattgtgaat gaaaatcaaa
     4921 atccatactt taaaggtaat catgttacta acaacctatt tttgaattca taaaaatttc
     4981 tttataaatg atgttttgtg aacatagtaa aatagaccat tatactatgt gtatgtttga
     5041 tacagcgtcg ccaaaactag tgttctttat tagtgcctct cacaaaagat cctggatgga
     5101 ggagtaagat gaaatattat gctattatat gatgctgttt gtaaaggtat taatgtacta
     5161 gtaaggtgtt aatgacaagg aattagtact attcctgttg taaagttaga ttttgcatat
     5221 tgtatctatc aaaatatgtt tgggtttaga ttttaagttg tctactgagc agatttctgc
     5281 attggttttc cagtcctgtt aaaagtttag aaacttcata tgtgtcatca cagcttttgt
     5341 aaagaaagta tccttaatat tttatgacat tctaccaca
//
