LOCUS       NM_015306              10800 bp    mRNA    linear   PRI 12-NOV-2024
DEFINITION  Homo sapiens ubiquitin specific peptidase 24 (USP24), mRNA.
ACCESSION   NM_015306 XM_371254 XM_942521
VERSION     NM_015306.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 10800)
  AUTHORS   Zhou,N., Guo,C., Li,X., Tu,L., Du,J., Qian,Q., Li,J., Huang,D.,
            Xu,Q. and Zheng,X.
  TITLE     USP24 promotes hepatocellular carcinoma tumorigenesis through
            deubiquitinating and stabilizing TRAF2
  JOURNAL   Biochem Pharmacol 229, 116473 (2024)
   PUBMED   39127151
  REMARK    GeneRIF: USP24 promotes hepatocellular carcinoma tumorigenesis
            through deubiquitinating and stabilizing TRAF2.
REFERENCE   2  (bases 1 to 10800)
  AUTHORS   Hu,Z., Zhao,Y., Mang,Y., Zhu,J., Yu,L., Li,L. and Ran,J.
  TITLE     MiR-21-5p promotes sorafenib resistance and hepatocellular
            carcinoma progression by regulating SIRT7 ubiquitination through
            USP24
  JOURNAL   Life Sci 325, 121773 (2023)
   PUBMED   37187452
  REMARK    GeneRIF: MiR-21-5p promotes sorafenib resistance and hepatocellular
            carcinoma progression by regulating SIRT7 ubiquitination through
            USP24.
REFERENCE   3  (bases 1 to 10800)
  AUTHORS   He,H., Yi,L., Zhang,B., Yan,B., Xiao,M., Ren,J., Zi,D., Zhu,L.,
            Zhong,Z., Zhao,X., Jin,X. and Xiong,W.
  TITLE     USP24-GSDMB complex promotes bladder cancer proliferation via
            activation of the STAT3 pathway
  JOURNAL   Int J Biol Sci 17 (10), 2417-2429 (2021)
   PUBMED   34326684
  REMARK    GeneRIF: USP24-GSDMB complex promotes bladder cancer proliferation
            via activation of the STAT3 pathway.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 10800)
  AUTHORS   Bedekovics,T., Hussain,S., Zhang,Y., Ali,A., Jeon,Y.J. and
            Galardy,P.J.
  TITLE     USP24 Is a Cancer-Associated Ubiquitin Hydrolase, Novel Tumor
            Suppressor, and Chromosome Instability Gene Deleted in
            Neuroblastoma
  JOURNAL   Cancer Res 81 (5), 1321-1331 (2021)
   PUBMED   33355202
  REMARK    GeneRIF: USP24 Is a Cancer-Associated Ubiquitin Hydrolase, Novel
            Tumor Suppressor, and Chromosome Instability Gene Deleted in
            Neuroblastoma.
REFERENCE   5  (bases 1 to 10800)
  AUTHORS   Wang,S.A., Young,M.J., Jeng,W.Y., Liu,C.Y. and Hung,J.J.
  TITLE     USP24 stabilizes bromodomain containing proteins to promote lung
            cancer malignancy
  JOURNAL   Sci Rep 10 (1), 20870 (2020)
   PUBMED   33257797
  REMARK    GeneRIF: USP24 stabilizes bromodomain containing proteins to
            promote lung cancer malignancy.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 10800)
  AUTHORS   Li,Y., Schrodi,S., Rowland,C., Tacey,K., Catanese,J. and Grupe,A.
  TITLE     Genetic evidence for ubiquitin-specific proteases USP24 and USP40
            as candidate genes for late-onset Parkinson disease
  JOURNAL   Hum Mutat 27 (10), 1017-1023 (2006)
   PUBMED   16917932
  REMARK    GeneRIF: Data suggest that genetic variants in USP24 affect the
            risk for late-onset Parkinson disease (PD), which is consistent
            with the predicted role of the ubiquitination pathway in PD
            etiology.
            GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   7  (bases 1 to 10800)
  AUTHORS   Beausoleil,S.A., Jedrychowski,M., Schwartz,D., Elias,J.E.,
            Villen,J., Li,J., Cohn,M.A., Cantley,L.C. and Gygi,S.P.
  TITLE     Large-scale characterization of HeLa cell nuclear phosphoproteins
  JOURNAL   Proc Natl Acad Sci U S A 101 (33), 12130-12135 (2004)
   PUBMED   15302935
REFERENCE   8  (bases 1 to 10800)
  AUTHORS   Brill,L.M., Salomon,A.R., Ficarro,S.B., Mukherji,M.,
            Stettler-Gill,M. and Peters,E.C.
  TITLE     Robust phosphoproteomic profiling of tyrosine phosphorylation sites
            from human T cells using immobilized metal affinity chromatography
            and tandem mass spectrometry
  JOURNAL   Anal Chem 76 (10), 2763-2772 (2004)
   PUBMED   15144186
REFERENCE   9  (bases 1 to 10800)
  AUTHORS   Quesada,V., Diaz-Perales,A., Gutierrez-Fernandez,A., Garabaya,C.,
            Cal,S. and Lopez-Otin,C.
  TITLE     Cloning and enzymatic analysis of 22 novel human ubiquitin-specific
            proteases
  JOURNAL   Biochem Biophys Res Commun 314 (1), 54-62 (2004)
   PUBMED   14715245
REFERENCE   10 (bases 1 to 10800)
  AUTHORS   Puente,X.S., Sanchez,L.M., Overall,C.M. and Lopez-Otin,C.
  TITLE     Human and mouse proteases: a comparative genomic approach
  JOURNAL   Nat Rev Genet 4 (7), 544-558 (2003)
   PUBMED   12838346
  REMARK    Review article
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC091609.2.
            
            On Nov 22, 2018 this sequence version replaced NM_015306.2.
            
            Summary: Modification of cellular proteins by ubiquitin is an
            essential regulatory mechanism controlled by the coordinated action
            of multiple ubiquitin-conjugating and deubiquitinating enzymes.
            USP24 belongs to a large family of cysteine proteases that function
            as deubiquitinating enzymes (Quesada et al., 2004 [PubMed
            14715245]).[supplied by OMIM, Mar 2008].
            
            Sequence Note: This RefSeq record was created from genomic sequence
            data because no single transcript was available for the full length
            of the gene. The extent of this transcript is supported by
            alignments of human and mouse transcripts.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038191.3951673.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000294383.7/ ENSP00000294383.5
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-575               AC091609.2         12354-12928
            576-741             AC091609.2         49586-49751
            742-809             AC091609.2         51275-51342
            810-953             AC091609.2         55198-55341
            954-1076            AC091609.2         56040-56162
            1077-1112           AC091609.2         61115-61150
            1113-1178           AC091609.2         61768-61833
            1179-1244           AC091609.2         65454-65519
            1245-1319           AC091609.2         68033-68107
            1320-1478           AC091609.2         68682-68840
            1479-1593           AC091609.2         70348-70462
            1594-1697           AC091609.2         70667-70770
            1698-1805           AC091609.2         72940-73047
            1806-1901           AC091609.2         73252-73347
            1902-2063           AC091609.2         73438-73599
            2064-2111           AC091609.2         73801-73848
            2112-2219           AC091609.2         79148-79255
            2220-2369           AC091609.2         79920-80069
            2370-2501           AC091609.2         80658-80789
            2502-2613           AC091609.2         81609-81720
            2614-2690           AC091609.2         83515-83591
            2691-2831           AC091609.2         84599-84739
            2832-2885           AC091609.2         84923-84976
            2886-3001           AC091609.2         85987-86102
            3002-3068           AC091609.2         88708-88774
            3069-3179           AC091609.2         89000-89110
            3180-3278           AC091609.2         89814-89912
            3279-3452           AC091609.2         90030-90203
            3453-3538           AC091609.2         93305-93390
            3539-3632           AC091609.2         93555-93648
            3633-3788           AC091609.2         95018-95173
            3789-3886           AC091609.2         98144-98241
            3887-3982           AC091609.2         101960-102055
            3983-4211           AC091609.2         102170-102398
            4212-4371           AC091609.2         103090-103249
            4372-4527           AC091609.2         104116-104271
            4528-4598           AC091609.2         106212-106282
            4599-4759           AC091609.2         106962-107122
            4760-4821           AC091609.2         117472-117533
            4822-5013           AC091609.2         120288-120479
            5014-5131           AC091609.2         121455-121572
            5132-5276           AC091609.2         123698-123842
            5277-5396           AC091609.2         126015-126134
            5397-5522           AC091609.2         126754-126879
            5523-5621           AC091609.2         127849-127947
            5622-5704           AC091609.2         129160-129242
            5705-5846           AC091609.2         129634-129775
            5847-5966           AC091609.2         130001-130120
            5967-6187           AC091609.2         130546-130766
            6188-6312           AC091609.2         131096-131220
            6313-6454           AC091609.2         132322-132463
            6455-6605           AC091609.2         133631-133781
            6606-6701           AC091609.2         134802-134897
            6702-6805           AC091609.2         135592-135695
            6806-6919           AC091609.2         137978-138091
            6920-7016           AC091609.2         141680-141776
            7017-7133           AC091609.2         143830-143946
            7134-7226           AC091609.2         144354-144446
            7227-7329           AC091609.2         146294-146396
            7330-7451           AC091609.2         148059-148180
            7452-7565           AC091609.2         149067-149180
            7566-7631           AC091609.2         150418-150483
            7632-7698           AC091609.2         152195-152261
            7699-7777           AC091609.2         153812-153890
            7778-7853           AC091609.2         154857-154932
            7854-7940           AC091609.2         155315-155401
            7941-8051           AC091609.2         155794-155904
            8052-10800          AC091609.2         158611-161359
FEATURES             Location/Qualifiers
     source          1..10800
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p32.3"
     gene            1..10800
                     /gene="USP24"
                     /note="ubiquitin specific peptidase 24"
                     /db_xref="GeneID:23358"
                     /db_xref="HGNC:HGNC:12623"
                     /db_xref="MIM:610569"
     exon            1..575
                     /gene="USP24"
                     /inference="alignment:Splign:2.1.0"
     CDS             252..8114
                     /gene="USP24"
                     /EC_number="3.4.19.12"
                     /note="ubiquitin specific protease 24; ubiquitin
                     thiolesterase 24; ubiquitin-specific processing protease
                     24; deubiquitinating enzyme 24; ubiquitin thioesterase 24"
                     /codon_start=1
                     /product="ubiquitin carboxyl-terminal hydrolase 24"
                     /protein_id="NP_056121.2"
                     /db_xref="CCDS:CCDS44154.2"
                     /db_xref="GeneID:23358"
                     /db_xref="HGNC:HGNC:12623"
                     /db_xref="MIM:610569"
                     /translation="MESEEEQHMTTLLCMGFSDPATIRKALRLAKNDINEAVALLTNE
                     RPGLDYGGYEPMDSGGGPSPGPGGGPRGDGGGDGGGGGPSRGGSTGGGGGFDPPPAYH
                     EVVDAEKNDENGNCSGEGIEFPTTNLYELESRVLTDHWSIPYKREESLGKCLLASTYL
                     ARLGLSESDENCRRFMDRCMPEAFKKLLTSSAVHKWGTEIHEGIYNMLMLLIELVAER
                     IKQDPIPTGLLGVLTMAFNPDNEYHFKNRMKVSQRNWAEVFGEGNMFAVSPVSTFQKE
                     PHGWVVDLVNKFGELGGFAAIQAKLHSEDIELGAVSALIQPLGVCAEYLNSSVVQPML
                     DPVILTTIQDVRSVEEKDLKDKRLVSIPELLSAVKLLCMRFQPDLVTIVDDLRLDILL
                     RMLKSPHFSAKMNSLKEVTKLIEDSTLSKSVKNAIDTDRLLDWLVENSVLSIALEGNI
                     DQAQYCDRIKGIIELLGSKLSLDELTKIWKIQSGQSSTVIENIHTIIAAAAVKFNSDQ
                     LNHLFVLIQKSWETESDRVRQKLLSLIGRIGREARFETTSGKVLDVLWELAHLPTLPS
                     SLIQQALEEHLTILSDAYAVKEAIKRSYIIKCIEDIKRPGEWSGLEKNKKDGFKSSQL
                     NNPQFVWVVPALRQLHEITRSFIKQTYQKQDKSIIQDLKKNFEIVKLVTGSLIACHRL
                     AAAVAGPGGLSGSTLVDGRYTYREYLEAHLKFLAFFLQEATLYLGWNRAKEIWECLVT
                     GQDVCELDREMCFEWFTKGQHDLESDVQQQLFKEKILKLESYEITMNGFNLFKTFFEN
                     VNLCDHRLKRQGAQLYVEKLELIGMDFIWKIAMESPDEEIANEAIQLIINYSYINLNP
                     RLKKDSVSLHKKFIADCYTRLEAASSALGGPTLTHAVTRATKMLTATAMPTVATSVQS
                     PYRSTKLVIIERLLLLAERYVITIEDFYSVPRTILPHGASFHGHLLTLNVTYESTKDT
                     FTVEAHSNETIGSVRWKIAKQLCSPVDNIQIFTNDSLLTVNKDQKLLHQLGFSDEQIL
                     TVKTSGSGTPSGSSADSSTSSSSSSSGVFSSSYAMEQEKSLPGVVMALVCNVFDMLYQ
                     LANLEEPRITLRVRKLLLLIPTDPAIQEALDQLDSLGRKKTLLSESSSQSSKSPSLSS
                     KQQHQPSASSILESLFRSFAPGMSTFRVLYNLEVLSSKLMPTADDDMARSCAKSFCEN
                     FLKAGGLSLVVNVMQRDSIPSEVDYETRQGVYSICLQLARFLLVGQTMPTLLDEDLTK
                     DGIEALSSRPFRNVSRQTSRQMSLCGTPEKSSYRQLSVSDRSSIRVEEIIPAARVAIQ
                     TMEVSDFTSTVACFMRLSWAAAAGRLDLVGSSQPIKESNSLCPAGIRNRLSSSGSNCS
                     SGSEGEPVALHAGICVRQQSVSTKDSLIAGEALSLLVTCLQLRSQQLASFYNLPCVAD
                     FIIDILLGSPSAEIRRVACDQLYTLSQTDTSAHPDVQKPNQFLLGVILTAQLPLWSPT
                     SIMRGVNQRLLSQCMEYFDLRCQLLDDLTTSEMEQLRISPATMLEDEITWLDNFEPNR
                     TAECETSEADNILLAGHLRLIKTLLSLCGAEKEMLGSSLIKPLLDDFLFRASRIILNS
                     HSPAGSAAISQQDFHPKCSTANSRLAAYEVLVMLADSSPSNLQIIIKELLSMHHQPDP
                     ALTKEFDYLPPVDSRSSSGFVGLRNGGATCYMNAVFQQLYMQPGLPESLLSVDDDTDN
                     PDDSVFYQVQSLFGHLMESKLQYYVPENFWKIFKMWNKELYVREQQDAYEFFTSLIDQ
                     MDEYLKKMGRDQIFKNTFQGIYSDQKICKDCPHRYEREEAFMALNLGVTSCQSLEISL
                     DQFVRGEVLEGSNAYYCEKCKEKRITVKRTCIKSLPSVLVIHLMRFGFDWESGRSIKY
                     DEQIRFPWMLNMEPYTVSGMARQDSSSEVGENGRSVDQGGGGSPRKKVALTENYELVG
                     VIVHSGQAHAGHYYSFIKDRRGCGKGKWYKFNDTVIEEFDLNDETLEYECFGGEYRPK
                     VYDQTNPYTDVRRRYWNAYMLFYQRVSDQNSPVLPKKSRVSVVRQEAEDLSLSAPSSP
                     EISPQSSPRPHRPNNDRLSILTKLVKKGEKKGLFVEKMPARIYQMVRDENLKFMKNRD
                     VYSSDYFSFVLSLASLNATKLKHPYYPCMAKVSLQLAIQFLFQTYLRTKKKLRVDTEE
                     WIATIEALLSKSFDACQWLVEYFISSEGRELIKIFLLECNVREVRVAVATILEKTLDS
                     ALFYQDKLKSLHQLLEVLLALLDKDVPENCKNCAQYFFLFNTFVQKQGIRAGDLLLRH
                     SALRHMISFLLGASRQNNQIRRWSSAQAREFGNLHNTVALLVLHSDVSSQRNVAPGIF
                     KQRPPISIAPSSPLLPLHEEVEALLFMSEGKPYLLEVMFALRELTGSLLALIEMVVYC
                     CFCNEHFSFTMLHFIKNQLETAPPHELKNTFQLLHEILVIEDPIQVERVKFVFETENG
                     LLALMHHSNHVDSSRCYQCVKFLVTLAQKCPAAKEYFKENSHHWSWAVQWLQKKMSEH
                     YWTPQSNVSNETSTGKTFQRTISAQDTLAYATALLNEKEQSGSSNGSESSPANENGDR
                     HLQQGSESPMMIGELRSDLDDVDP"
     exon            576..741
                     /gene="USP24"
                     /inference="alignment:Splign:2.1.0"
     exon            742..809
                     /gene="USP24"
                     /inference="alignment:Splign:2.1.0"
     exon            810..953
                     /gene="USP24"
                     /inference="alignment:Splign:2.1.0"
     exon            954..1076
                     /gene="USP24"
                     /inference="alignment:Splign:2.1.0"
     exon            1077..1112
                     /gene="USP24"
                     /inference="alignment:Splign:2.1.0"
     exon            1113..1178
                     /gene="USP24"
                     /inference="alignment:Splign:2.1.0"
     exon            1179..1244
                     /gene="USP24"
                     /inference="alignment:Splign:2.1.0"
     exon            1245..1319
                     /gene="USP24"
                     /inference="alignment:Splign:2.1.0"
     exon            1320..1478
                     /gene="USP24"
                     /inference="alignment:Splign:2.1.0"
     exon            1479..1593
                     /gene="USP24"
                     /inference="alignment:Splign:2.1.0"
     exon            1594..1697
                     /gene="USP24"
                     /inference="alignment:Splign:2.1.0"
     exon            1698..1805
                     /gene="USP24"
                     /inference="alignment:Splign:2.1.0"
     exon            1806..1901
                     /gene="USP24"
                     /inference="alignment:Splign:2.1.0"
     exon            1902..2063
                     /gene="USP24"
                     /inference="alignment:Splign:2.1.0"
     exon            2064..2111
                     /gene="USP24"
                     /inference="alignment:Splign:2.1.0"
     exon            2112..2219
                     /gene="USP24"
                     /inference="alignment:Splign:2.1.0"
     exon            2220..2369
                     /gene="USP24"
                     /inference="alignment:Splign:2.1.0"
     exon            2370..2501
                     /gene="USP24"
                     /inference="alignment:Splign:2.1.0"
     exon            2502..2613
                     /gene="USP24"
                     /inference="alignment:Splign:2.1.0"
     exon            2614..2690
                     /gene="USP24"
                     /inference="alignment:Splign:2.1.0"
     exon            2691..2831
                     /gene="USP24"
                     /inference="alignment:Splign:2.1.0"
     exon            2832..2885
                     /gene="USP24"
                     /inference="alignment:Splign:2.1.0"
     exon            2886..3001
                     /gene="USP24"
                     /inference="alignment:Splign:2.1.0"
     exon            3002..3068
                     /gene="USP24"
                     /inference="alignment:Splign:2.1.0"
     exon            3069..3179
                     /gene="USP24"
                     /inference="alignment:Splign:2.1.0"
     exon            3180..3278
                     /gene="USP24"
                     /inference="alignment:Splign:2.1.0"
     exon            3279..3452
                     /gene="USP24"
                     /inference="alignment:Splign:2.1.0"
     exon            3453..3538
                     /gene="USP24"
                     /inference="alignment:Splign:2.1.0"
     exon            3539..3632
                     /gene="USP24"
                     /inference="alignment:Splign:2.1.0"
     exon            3633..3788
                     /gene="USP24"
                     /inference="alignment:Splign:2.1.0"
     exon            3789..3886
                     /gene="USP24"
                     /inference="alignment:Splign:2.1.0"
     exon            3887..3982
                     /gene="USP24"
                     /inference="alignment:Splign:2.1.0"
     exon            3983..4211
                     /gene="USP24"
                     /inference="alignment:Splign:2.1.0"
     exon            4212..4371
                     /gene="USP24"
                     /inference="alignment:Splign:2.1.0"
     exon            4372..4527
                     /gene="USP24"
                     /inference="alignment:Splign:2.1.0"
     exon            4528..4598
                     /gene="USP24"
                     /inference="alignment:Splign:2.1.0"
     exon            4599..4759
                     /gene="USP24"
                     /inference="alignment:Splign:2.1.0"
     exon            4760..4821
                     /gene="USP24"
                     /inference="alignment:Splign:2.1.0"
     exon            4822..5013
                     /gene="USP24"
                     /inference="alignment:Splign:2.1.0"
     exon            5014..5131
                     /gene="USP24"
                     /inference="alignment:Splign:2.1.0"
     exon            5132..5276
                     /gene="USP24"
                     /inference="alignment:Splign:2.1.0"
     exon            5277..5396
                     /gene="USP24"
                     /inference="alignment:Splign:2.1.0"
     exon            5397..5522
                     /gene="USP24"
                     /inference="alignment:Splign:2.1.0"
     exon            5523..5621
                     /gene="USP24"
                     /inference="alignment:Splign:2.1.0"
     exon            5622..5704
                     /gene="USP24"
                     /inference="alignment:Splign:2.1.0"
     exon            5705..5846
                     /gene="USP24"
                     /inference="alignment:Splign:2.1.0"
     exon            5847..5966
                     /gene="USP24"
                     /inference="alignment:Splign:2.1.0"
     exon            5967..6187
                     /gene="USP24"
                     /inference="alignment:Splign:2.1.0"
     exon            6188..6312
                     /gene="USP24"
                     /inference="alignment:Splign:2.1.0"
     exon            6313..6454
                     /gene="USP24"
                     /inference="alignment:Splign:2.1.0"
     exon            6455..6605
                     /gene="USP24"
                     /inference="alignment:Splign:2.1.0"
     exon            6606..6701
                     /gene="USP24"
                     /inference="alignment:Splign:2.1.0"
     exon            6702..6805
                     /gene="USP24"
                     /inference="alignment:Splign:2.1.0"
     exon            6806..6919
                     /gene="USP24"
                     /inference="alignment:Splign:2.1.0"
     exon            6920..7016
                     /gene="USP24"
                     /inference="alignment:Splign:2.1.0"
     exon            7017..7133
                     /gene="USP24"
                     /inference="alignment:Splign:2.1.0"
     exon            7134..7226
                     /gene="USP24"
                     /inference="alignment:Splign:2.1.0"
     exon            7227..7329
                     /gene="USP24"
                     /inference="alignment:Splign:2.1.0"
     exon            7330..7451
                     /gene="USP24"
                     /inference="alignment:Splign:2.1.0"
     exon            7452..7565
                     /gene="USP24"
                     /inference="alignment:Splign:2.1.0"
     exon            7566..7631
                     /gene="USP24"
                     /inference="alignment:Splign:2.1.0"
     exon            7632..7698
                     /gene="USP24"
                     /inference="alignment:Splign:2.1.0"
     exon            7699..7777
                     /gene="USP24"
                     /inference="alignment:Splign:2.1.0"
     exon            7778..7853
                     /gene="USP24"
                     /inference="alignment:Splign:2.1.0"
     exon            7854..7940
                     /gene="USP24"
                     /inference="alignment:Splign:2.1.0"
     exon            7941..8051
                     /gene="USP24"
                     /inference="alignment:Splign:2.1.0"
     exon            8052..10800
                     /gene="USP24"
                     /inference="alignment:Splign:2.1.0"
     regulatory      10780..10785
                     /regulatory_class="polyA_signal_sequence"
                     /gene="USP24"
                     /note="hexamer: AATAAA"
     polyA_site      10800
                     /gene="USP24"
                     /note="major polyA site"
ORIGIN      
        1 aggaggccaa catggcggcg cgcagggctg ggccgggccg cagccgcgcc tgagcgcctc
       61 accgcactag ctcggctcgc aggacccaag cccgcaccca gcctggcccg gctgctgcgg
      121 agcacccggg gcaggaacgc aggggccaac ctgggcgcgg aggcggcgcg gagggtgcgc
      181 cgcgcggccc gccaggcccg ggacccgtag cttcgccgtg cgctggccgg ggcggccagg
      241 aggcccaagc catggaatcg gaggaggagc agcacatgac cacgctgctg tgcatgggct
      301 tctcagaccc cgccaccatc cgcaaggccc tgcgcctggc caagaacgac attaacgagg
      361 ccgtggcact gctcaccaac gagcggccgg gcctcgacta cggcggctac gagcccatgg
      421 acagcggcgg tggccccagc cccgggcccg gcgggggccc gcggggcgac ggcggaggtg
      481 acggcggcgg cggcggcccc tcccgcggcg ggagcaccgg aggcgggggc ggcttcgacc
      541 ccccgcccgc ctaccacgag gtggtggacg cggagaagaa tgatgagaat ggaaactgct
      601 caggggaagg aattgaattc cctacaacaa atttatatga actggaaagc cgtgttttga
      661 ctgatcattg gtccatccct tacaagcgag aagaatcact aggcaaatgc ctgttggcat
      721 ctacctacct agcaagactt ggtctttccg agtctgatga gaattgtaga aggtttatgg
      781 acaggtgtat gcctgaagca tttaaaaagc tcctgacatc aagtgctgtt cacaagtggg
      841 gtactgaaat tcatgaagga atttacaaca tgttgatgct attaatagaa ctggtcgcag
      901 agagaataaa acaagatcca attcccactg gtctcctggg tgtgcttaca atggctttca
      961 atcctgataa tgaataccat tttaaaaaca gaatgaaagt gtctcaaagg aattgggcag
     1021 aagtgtttgg agagggaaat atgtttgctg tttcacctgt atcgactttc caaaaggagc
     1081 ctcatggatg ggttgtggat ttggtaaata agtttggaga attaggtgga tttgcagcaa
     1141 tccaagccaa gctccattca gaagatatag aacttggggc tgtctcagca ctgattcagc
     1201 ccttaggagt gtgtgcagag tacctcaatt cctccgtggt acagcccatg ctagacccag
     1261 tcattcttac tacaatccag gatgtacgga gtgtagaaga gaaagacctc aaagacaaga
     1321 gattggttag catccctgag ctcttgtctg ccgttaagtt actttgcatg cgcttccaac
     1381 cggatctggt gacaattgtg gatgaccttc gactagatat tctattgcgc atgctgaaat
     1441 caccacattt cagtgctaag atgaattctc tcaaagaagt aaccaaacta atagaagata
     1501 gcactttatc caaatctgtg aagaatgcta tagatacaga cagattatta gattggctag
     1561 ttgaaaactc agttctgtcg attgcactgg aaggcaacat agaccaagca caatactgtg
     1621 accgtataaa gggaattatt gaactcttgg gtagtaaatt gtcgttagat gaactcacta
     1681 aaatttggaa gatacagtca ggacaatcat ctactgtgat tgagaacatt catactatta
     1741 ttgctgcagc ggctgtgaaa tttaattcag atcagcttaa tcatttgttt gttctcattc
     1801 agaagagctg ggagactgag agtgatagag taagacagaa gcttttgagc ctgattggac
     1861 gaataggccg ggaagctcgc tttgagacca cttctggaaa ggttttagac gtactctggg
     1921 aactggctca ccttccaacc ctgcccagta gccttattca gcaggccttg gaggagcacc
     1981 tgacaatcct tagtgatgca tatgcagtga aagaagcaat caagaggagc tacatcatca
     2041 agtgcataga agatattaag aggcctggag aatggtcagg tttggaaaaa aacaagaagg
     2101 atggattcaa gtcatctcag cttaataatc cccagtttgt atgggtggta ccagctttgc
     2161 gtcagctcca tgaaattact cgctcattca taaaacaaac ctatcaaaag caagacaaga
     2221 gcattattca agacttgaag aagaattttg aaatagtgaa attggtaacg ggaagtttga
     2281 tcgcttgtca tcggcttgca gctgctgtgg ccgggcctgg aggcttaagt ggctcgacac
     2341 tagtggatgg ccggtacact taccgggagt atttagaggc acatctaaaa tttctagcgt
     2401 ttttcttgca agaagctact ctgtatctgg gctggaatcg tgccaaggag atctgggagt
     2461 gtcttgtaac tggccaggat gtttgtgaat tagatagaga gatgtgtttt gaatggttta
     2521 caaaaggaca gcatgatctt gagagtgatg ttcagcagca gctcttcaag gagaaaattc
     2581 ttaaattgga gtcatatgaa atcactatga atggttttaa cttatttaaa actttttttg
     2641 aaaatgtgaa tctttgtgat catcgattga aaagacaagg agctcagttg tatgtagaaa
     2701 agctggaatt gataggaatg gatttcattt ggaaaatagc catggaatca cctgatgaag
     2761 aaattgctaa tgaagctatt cagctaatca taaactatag ttacattaat ctaaatccta
     2821 gattaaagaa ggattcagta tctttacata agaaattcat tgctgattgc tacacaagat
     2881 tagaagcagc cagttcagca cttggtggcc ccactctaac acatgctgtg accagagcaa
     2941 caaaaatgct tacagcaact gccatgccaa ctgtagcaac ctcagttcag tctccttata
     3001 gatctactaa acttgtaata attgagagat tgctgcttct ggcagagcgc tatgtgatca
     3061 ctatagagga tttttactct gttccacgaa ctattctacc tcatggtgcc tcatttcatg
     3121 gacatctttt aacccttaat gttacctatg agtctaccaa agataccttc actgtcgagg
     3181 ctcacagtaa tgaaaccata gggagtgtcc ggtggaaaat agccaagcag ttgtgctctc
     3241 ctgtggataa tatacagata tttacaaatg atagcctgct gacagtgaat aaagatcaaa
     3301 agctactcca ccaactgggc ttttctgatg aacaaatcct tacagtgaag acttctggca
     3361 gtgggacccc atctgggagt tcagcagatt cttcaaccag ctccagcagc agcagcagtg
     3421 gggtttttag ttcttcatat gccatggagc aggagaaatc cctccctggt gtagtgatgg
     3481 ctctcgtatg taacgtattt gacatgcttt atcagctcgc caatctggaa gagccaagga
     3541 taactctacg agtacggaag cttctgctct tgatacccac tgatccagcc attcaggaag
     3601 cccttgatca acttgattct ttaggaagaa agaaaacatt gctgtctgaa tcaagttctc
     3661 agtcctcaaa atctccatcc ctgtcatcaa agcaacagca ccagccaagt gccagttcaa
     3721 ttttagaaag tctgtttcga tcttttgccc cgggaatgtc taccttcaga gtgctctaca
     3781 acttagaagt tctaagctcc aaactcatgc caacagctga tgatgacatg gccagaagct
     3841 gtgccaaatc cttctgtgaa aacttcctca aagctggcgg tttgagtttg gttgtaaatg
     3901 tcatgcagag agactccatc ccatcagaag tagactatga aacaaggcag ggtgtttatt
     3961 ccatctgtct acagcttgca agatttttac ttgtcggaca aacaatgccc acgttattag
     4021 atgaagacct caccaaagat ggtatagaag cactttcttc ccgcccattc cgaaatgtca
     4081 gccggcagac aagcagacag atgtccttat gtggtacccc agaaaagtca tcctaccgac
     4141 agttgtccgt gtctgatagg tcttctatta gggttgagga aatcatccct gctgctcgag
     4201 ttgcaataca aacaatggaa gtaagtgatt tcacttctac tgtggcttgc ttcatgagat
     4261 tgtcatgggc tgcggctgca ggacggcttg atcttgttgg gagtagccag ccaattaaag
     4321 aaagtaattc cctgtgtcct gctggaattc gaaacagact cagcagttca ggaagcaatt
     4381 gcagctctgg aagtgaagga gaaccagtag ccctgcatgc gggaatctgt gttcgacaac
     4441 agtctgtatc caccaaagac tcgctgattg cgggagaggc tttgtctctt cttgttacgt
     4501 gcctacagct tcggagccag caactggcat ctttctataa cttgccctgt gttgctgatt
     4561 tcatcattga tattctgctc ggatcaccaa gtgctgagat tcgccgggtt gcctgtgatc
     4621 agctgtacac tcttagtcag acagacacat cagcgcatcc agatgtgcag aagccaaatc
     4681 agtttcttct aggcgtaatc ctcacggctc agctgcctct ctggtctcca actagtatta
     4741 tgagaggagt caatcagaga ctgttatctc agtgtatgga gtattttgat ttgagatgcc
     4801 agttattaga tgatctgaca acttcagaaa tggagcagtt aaggatcagc ccagctacga
     4861 tgcttgaaga tgagattact tggctggata actttgaacc taatcgtaca gctgaatgtg
     4921 agaccagtga agcggacaac atcttactgg cagggcactt acgcctcatc aagacccttc
     4981 tttcactctg tggggcagaa aaggaaatgc ttggttcatc actcattaaa ccattgttag
     5041 atgacttcct tttccgagct tctagaatta ttttaaatag tcattctcca gctggcagtg
     5101 ccgccatcag tcaacaggac tttcatccaa agtgtagtac agcgaatagc cgattggcag
     5161 cctatgaagt ccttgtgatg ttggctgata gttcaccttc aaatcttcaa attattataa
     5221 aagaactgct ttctatgcat caccagcctg accctgctct taccaaggag tttgattacc
     5281 ttcccccagt ggatagcagg tccagttcag ggtttgtggg gctgagaaat ggtggtgcaa
     5341 cttgttatat gaatgcagtc ttccagcagc tgtatatgca acctgggctc cctgagtcat
     5401 tactttcagt ggatgatgac acagacaatc cagatgatag cgtgttttac caagtgcagt
     5461 ctctctttgg acatttaatg gaaagcaagc tgcagtacta tgtacctgag aatttttgga
     5521 agattttcaa gatgtggaat aaagaacttt atgtgagaga acagcaggat gcatatgaat
     5581 tctttactag tctcattgat cagatggatg aatacctcaa gaaaatgggg agagaccaaa
     5641 tttttaagaa tacatttcag ggcatctact ctgatcagaa gatctgtaaa gactgtcctc
     5701 acagatatga gcgtgaagaa gctttcatgg ctctcaatct aggagtgact tcttgtcaga
     5761 gtttggaaat ttctttggac caatttgtta gaggagaagt tctagaagga agtaatgcgt
     5821 actactgtga aaagtgtaaa gaaaagagaa taacagtgaa aaggacctgt attaaatctt
     5881 tacctagcgt cttggtaatt cacctaatga gatttgggtt tgactgggaa agcggacgct
     5941 ccattaaata tgatgaacaa ataaggtttc cctggatgct aaacatggag ccttacacag
     6001 tttcaggaat ggctcgccaa gattcttctt ctgaagttgg ggaaaatggg cgaagtgtgg
     6061 atcagggcgg tggaggatcc ccacgaaaaa aggttgccct cacagaaaac tatgaacttg
     6121 tcggtgtcat cgtacacagt gggcaggcac acgcaggcca ctactattcc ttcattaagg
     6181 acaggcgagg gtgtggaaaa ggaaagtggt ataaatttaa tgacacagtt atagaagaat
     6241 ttgacctaaa tgacgagacc ctggagtatg aatgctttgg aggagaatat agaccaaaag
     6301 tttatgatca aacaaaccca tacactgatg tgcgccgaag atactggaat gcctatatgc
     6361 ttttctacca aagggtgtct gatcagaact ccccagtatt accaaagaaa agtcgagtca
     6421 gcgttgtacg gcaggaagct gaggatctct ctctgtcagc tccatcttca ccagaaattt
     6481 cacctcagtc atcccctcgg ccccataggc cgaacaatga ccggctgtct attcttacca
     6541 agctggttaa aaaaggcgag aagaaaggac tgtttgtgga gaaaatgcct gctcgaatat
     6601 accagatggt gagagatgag aacctcaagt ttatgaagaa tagagatgta tacagtagtg
     6661 attatttcag ttttgttttg tctttagctt cattgaatgc tactaaatta aagcatccat
     6721 attatccttg catggcaaag gtgagcttac agcttgctat tcaattcctt tttcaaactt
     6781 atctacggac aaagaagaaa ctcagggttg atactgaaga atggattgct accattgaag
     6841 cattgctttc aaaaagtttt gatgcttgtc agtggttagt tgaatatttt attagttctg
     6901 aaggacgaga attgataaag attttcttac tggagtgcaa tgtgagagaa gtacgagttg
     6961 ctgtggccac cattctggag aaaaccctag acagtgcctt gttttatcag gataagttaa
     7021 aaagccttca tcagttactg gaggtactac ttgctctgtt ggacaaagac gtcccagaaa
     7081 attgtaaaaa ctgtgctcag tactttttcc tgttcaacac ttttgtacaa aagcaaggaa
     7141 ttagggctgg agatcttctt ctgaggcatt cagctctgcg gcacatgatc agcttcctcc
     7201 taggggccag tcggcaaaac aatcagatac gtcgatggag ttcagcacaa gcacgagaat
     7261 ttgggaatct tcacaataca gtggcgttac ttgttttgca ttcagatgtc tcatcccaaa
     7321 ggaatgttgc tcctggcata tttaagcaac gaccacccat tagcattgct ccctcaagcc
     7381 ctctgttgcc cctccatgag gaggtagaag ccttgttgtt catgtctgaa gggaaacctt
     7441 acctgttaga ggtaatgttt gctttgcggg agctgacagg ctcgctcttg gcactcattg
     7501 agatggtagt gtactgctgt ttctgtaatg agcatttttc cttcacaatg ctgcatttca
     7561 ttaagaacca actagaaacg gctccacctc atgagttaaa gaatacgttc caactacttc
     7621 atgaaatatt ggttattgaa gatcctatac aagtagagcg agtcaaattt gtgtttgaga
     7681 cagaaaatgg attactagct ttgatgcacc acagtaatca tgtggacagt agtcgctgct
     7741 accagtgtgt caaatttctt gtcactcttg ctcaaaagtg tcctgcagct aaggagtact
     7801 tcaaggagaa ttcccaccac tggagctggg ctgtgcagtg gctacagaag aagatgtcag
     7861 aacattactg gacaccacag agtaatgtct ctaatgaaac atcaactgga aaaacctttc
     7921 agcgaaccat ttcagctcag gacacgttag cgtatgccac agctttgttg aatgaaaaag
     7981 agcaatcagg aagcagtaat gggtcggaga gtagtcctgc caatgagaac ggagacaggc
     8041 atctacagca gggttcagaa tctcccatga tgattggtga gttgagaagt gaccttgatg
     8101 atgttgatcc ctagaggaac atgcccagcc tgagaggagt caagacacaa tactggatgc
     8161 tcagcacctt cttggaatca gaatctcgaa ccctttggaa gagcctggag attggactgg
     8221 gaaagctgct gtgacttggg cggatcgtgt atttctcaag gaaagcattt ttaagccact
     8281 agaaggtttg ggagctgttt ggcagtggga gaactccggc atgtggatca gctgtcccgg
     8341 gagcgtggtc tatatgtgga ttcacatttc tgtggagatt ttcggaaata gagccagtgg
     8401 cagacttttt tgttacacga acatacaaga gtgagcataa agctgttgct ttctctacga
     8461 tgctacaaaa gaaattcctt tggtttttat attttaagaa aaagcaagct gcttttagat
     8521 atgtgggggc aaatttttaa tcttgcagta atattaaaca ggaatatcca atttaaaatg
     8581 atgtaaagat gtaataaaat tccttttcat tgtaaaatag taattaagtc aatttacaca
     8641 gacctttgta tttaatatgt ctccctattt gtatagaatt tcagatgggt ctagatgaga
     8701 accctatgca taagcttgga tcttgatgaa aggttaccag gatcaggatc aaaaattggg
     8761 aaatactaag ctcttgaaga tatttttctg atataattag attgaaaaga gcaattttga
     8821 aaatgctgtg ttctccagaa gtacagggtg cattatttga catcaattac ttaaagaagt
     8881 tatgagttgt tccccaaaca gattttaaaa acagcaaaat aaaagcactt taagatataa
     8941 ttttactgag tttaacttca cagaattatc tttttaatgc ttggagacat attgaataaa
     9001 ctgtagtctt aaatcatgtg atctgcaatc gtttgctttt gcttaaaaca taattactga
     9061 aacccttggt attggttgta tatgaagtta actatttgag ttggtacaca ctgcttgtga
     9121 gtttcatagt tattgtaatg cagagaagga atttgagaat ttgtttctcc tcaacatgac
     9181 taattaacac tgaaaagtca gtcaaggttt aagatttatt ttcccagaaa taaatataaa
     9241 gcaattgaat aaccatccat ttagtcgtat ttccaaagta tagcaccatt cactcattta
     9301 taccagctcc cttttatggt gtgggggaga ggtttacacc cacatatttc atatatattt
     9361 tgtacatttt gtattttgaa ttgctcacat tttcggccct gttttgcctt tagttacagg
     9421 tcctgcctta ttttcatctc accatgcaca gaactaggga gccttaggaa gtgccaggtt
     9481 ttcactgtca gatttgccaa gtcacagagg cgcagccagc cctgaagtgc ctgtctggct
     9541 gctgtggcat tgtgtgggca tgtggccagg cagatggcat ctcattactg tgctctcgcc
     9601 atggcccagt cttttcattc tctggcagtg agggtttctg tgctgtcaga cttcattgtt
     9661 attctgtgac ttgctggagg ttggcagtgg cctttgtcaa acacactgag aagatggaag
     9721 ggccagcact taagagcaga actgtaccct tagagaaacg gacagaggcg agtggcaaac
     9781 ttcagacggt tccaatggtc ttgcagtttg aaatgtgatg ttctaccatt ggttttgagt
     9841 acgtgaatac ttcctgtcct actgtttccc ctaccctatt ctcaccttct ctccgcccac
     9901 atcctcacca agagattgtg tgggacatga ccttgaaatg ctggcgatga tccacactgg
     9961 gatatcatcg ctggcgactg cactctcagg agcccaaaat caggagtgaa attgccactt
    10021 ctagtcccct tatttcctat ggaaacaacg ccttccgcac ccctagcacc tgccgtcctc
    10081 actgtaaagc ttcatcagga tcgtccaccg tgtatattat acgcttcaga tcatgttgct
    10141 tatattgttg ctgcaatgac catcgttttc actttgctgg taaccacttg attgctgaca
    10201 gctacagtca atgaacctgc tgatgacttt ttttaatgta gtacaacagt gacagttatg
    10261 acaggcttac cttggaagag ttgtcatttt tactgccaat tttttggatg aagatgtttt
    10321 tataaacctt tcaaaatggt ctgcaaacag agcaggaatt gcacaattaa ctcaataatg
    10381 ctgtgtgttc tcaagaagct cccttagtga ggccgatctt aagatggccg attctgcccg
    10441 ttgaaggcat cctgggaaag aaaacaagca tcccagcggg catctcacca cgacttctcc
    10501 tggagtcctc acacggtcac tgacaactac agtcagtttt aggaactaga gtgccgtatc
    10561 atcagactta ccctgtcctg ccccaccttc cctgctaaca tcgaggtgtg tgcagttacc
    10621 ttctgagctt ggaacaagca gactggaatt ttcctctgct acctcttgtg tataaaatct
    10681 tgtttataaa atttcaaaag gaagtagata cactagggaa gaaccttaat tctaaatttg
    10741 gttcatgtgt ggcaaagttc ttagcttcta agagtataaa ataaattttt caaaaacaga
//
