LOCUS       NM_015276               5189 bp    mRNA    linear   PRI 29-OCT-2024
DEFINITION  Homo sapiens ubiquitin specific peptidase 22 (USP22), mRNA.
ACCESSION   NM_015276 XM_042698 XM_945855
VERSION     NM_015276.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5189)
  AUTHORS   Zhen,F., Sun,Y., Wang,H., Liu,W., Liang,X., Wang,Y., Wang,Q. and
            Hu,J.
  TITLE     Ubiquitin-Specific Protease 22 Plays a Key Role in Increasing
            Extracellular Vesicle Secretion and Regulating Cell Motility of
            Lung Adenocarcinoma
  JOURNAL   Adv Sci (Weinh) 11 (38), e2405731 (2024)
   PUBMED   39101247
  REMARK    GeneRIF: Ubiquitin-Specific Protease 22 Plays a Key Role in
            Increasing Extracellular Vesicle Secretion and Regulating Cell
            Motility of Lung Adenocarcinoma.
REFERENCE   2  (bases 1 to 5189)
  AUTHORS   Zhou,M., Gao,Y., Wu,S., Wang,Y. and Yang,J.
  TITLE     USP22 is required for human endometrial stromal cell proliferation
            and decidualization by deubiquitinating FoxM1
  JOURNAL   Cell Signal 121, 111265 (2024)
   PUBMED   38897527
  REMARK    GeneRIF: USP22 is required for human endometrial stromal cell
            proliferation and decidualization by deubiquitinating FoxM1.
REFERENCE   3  (bases 1 to 5189)
  AUTHORS   Zhang,Q., Zhu,J., Xie,J., Gu,Y. and Chen,L.
  TITLE     USP22 as a key regulator of glycolysis pathway in osteosarcoma:
            insights from bioinformatics and experimental approaches
  JOURNAL   PeerJ 12, e17397 (2024)
   PUBMED   38784391
  REMARK    GeneRIF: USP22 as a key regulator of glycolysis pathway in
            osteosarcoma: insights from bioinformatics and experimental
            approaches.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 5189)
  AUTHORS   Prokakis,E., Bamahmoud,H., Jansari,S., Fritsche,L., Dietz,A.,
            Boshnakovska,A., Rehling,P., Johnsen,S.A., Gallwas,J. and
            Wegwitz,F.
  TITLE     USP22 supports the aggressive behavior of basal-like breast cancer
            by stimulating cellular respiration
  JOURNAL   Cell Commun Signal 22 (1), 120 (2024)
   PUBMED   38347585
  REMARK    GeneRIF: USP22 supports the aggressive behavior of basal-like
            breast cancer by stimulating cellular respiration.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5189)
  AUTHORS   Liu,J., Wang,Y., Zhang,S., Sun,L. and Shi,Y.
  TITLE     ADAM9 deubiquitination induced by USP22 suppresses proliferation,
            migration, invasion, and epithelial-mesenchymal transition of
            trophoblast cells in preeclampsia
  JOURNAL   Placenta 146, 50-57 (2024)
   PUBMED   38176298
  REMARK    GeneRIF: ADAM9 deubiquitination induced by USP22 suppresses
            proliferation, migration, invasion, and epithelial-mesenchymal
            transition of trophoblast cells in preeclampsia.
REFERENCE   6  (bases 1 to 5189)
  AUTHORS   Bagheri-Fam,S., Ferraz,C., Demaille,J., Scherer,G. and Pfeifer,D.
  TITLE     Comparative genomics of the SOX9 region in human and Fugu rubripes:
            conservation of short regulatory sequence elements within large
            intergenic regions
  JOURNAL   Genomics 78 (1-2), 73-82 (2001)
   PUBMED   11707075
REFERENCE   7  (bases 1 to 5189)
  AUTHORS   Martinez,E., Palhan,V.B., Tjernberg,A., Lymar,E.S., Gamper,A.M.,
            Kundu,T.K., Chait,B.T. and Roeder,R.G.
  TITLE     Human STAGA complex is a chromatin-acetylating transcription
            coactivator that interacts with pre-mRNA splicing and DNA
            damage-binding factors in vivo
  JOURNAL   Mol Cell Biol 21 (20), 6782-6795 (2001)
   PUBMED   11564863
REFERENCE   8  (bases 1 to 5189)
  AUTHORS   Brand,M., Moggs,J.G., Oulad-Abdelghani,M., Lejeune,F.,
            Dilworth,F.J., Stevenin,J., Almouzni,G. and Tora,L.
  TITLE     UV-damaged DNA-binding protein in the TFTC complex links DNA damage
            recognition to nucleosome acetylation
  JOURNAL   EMBO J 20 (12), 3187-3196 (2001)
   PUBMED   11406595
REFERENCE   9  (bases 1 to 5189)
  AUTHORS   Brand,M., Yamamoto,K., Staub,A. and Tora,L.
  TITLE     Identification of TATA-binding protein-free TAFII-containing
            complex subunits suggests a role in nucleosome acetylation and
            signal transduction
  JOURNAL   J Biol Chem 274 (26), 18285-18289 (1999)
   PUBMED   10373431
REFERENCE   10 (bases 1 to 5189)
  AUTHORS   Wieczorek,E., Brand,M., Jacq,X. and Tora,L.
  TITLE     Function of TAF(II)-containing complex without TBP in transcription
            by RNA polymerase II
  JOURNAL   Nature 393 (6681), 187-191 (1998)
   PUBMED   9603525
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AB028986.1, BX640815.1 and AL110213.1.
            
            On Nov 23, 2018 this sequence version replaced NM_015276.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB028986.1, SRR11853558.10156.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000261497.9/ ENSP00000261497.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-496               AB028986.1         29-524
            497-1314            BX640815.1         107-924
            1315-1831           AB028986.1         1343-1859
            1832-2792           BX640815.1         1443-2403
            2793-3013           AB028986.1         2822-3042
            3014-4194           BX640815.1         2625-3805
            4195-5188           AB028986.1         4230-5223
            5189-5189           AL110213.1         1493-1493
FEATURES             Location/Qualifiers
     source          1..5189
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17p11.2"
     gene            1..5189
                     /gene="USP22"
                     /gene_synonym="USP3L"
                     /note="ubiquitin specific peptidase 22"
                     /db_xref="GeneID:23326"
                     /db_xref="HGNC:HGNC:12621"
                     /db_xref="MIM:612116"
     exon            1..347
                     /gene="USP22"
                     /gene_synonym="USP3L"
                     /inference="alignment:Splign:2.1.0"
     CDS             177..1754
                     /gene="USP22"
                     /gene_synonym="USP3L"
                     /EC_number="3.4.19.12"
                     /note="ubiquitin specific protease 22; ubiquitin
                     thiolesterase 22; ubiquitin-specific processing protease
                     22; deubiquitinating enzyme 22; ubiquitin thioesterase 22"
                     /codon_start=1
                     /product="ubiquitin carboxyl-terminal hydrolase 22"
                     /protein_id="NP_056091.1"
                     /db_xref="CCDS:CCDS42285.1"
                     /db_xref="GeneID:23326"
                     /db_xref="HGNC:HGNC:12621"
                     /db_xref="MIM:612116"
                     /translation="MVSRPEPEGEAMDAELAVAPPGCSHLGSFKVDNWKQNLRAIYQC
                     FVWSGTAEARKRKAKSCICHVCGVHLNRLHSCLYCVFFGCFTKKHIHEHAKAKRHNLA
                     IDLMYGGIYCFLCQDYIYDKDMEIIAKEEQRKAWKMQGVGEKFSTWEPTKRELELLKH
                     NPKRRKITSNCTIGLRGLINLGNTCFMNCIVQALTHTPLLRDFFLSDRHRCEMQSPSS
                     CLVCEMSSLFQEFYSGHRSPHIPYKLLHLVWTHARHLAGYEQQDAHEFLIAALDVLHR
                     HCKGDDNGKKANNPNHCNCIIDQIFTGGLQSDVTCQVCHGVSTTIDPFWDISLDLPGS
                     STPFWPLSPGSEGNVVNGESHVSGTTTLTDCLRRFTRPEHLGSSAKIKCSGCHSYQES
                     TKQLTMKKLPIVACFHLKRFEHSAKLRRKITTYVSFPLELDMTPFMASSKESRMNGQY
                     QQPTDSLNNDNKYSLFAVVNHQGTLESGHYTSFIRQHKDQWFKCDDAIITKASIKDVL
                     DSEGYLLFYHKQFLEYE"
     exon            348..480
                     /gene="USP22"
                     /gene_synonym="USP3L"
                     /inference="alignment:Splign:2.1.0"
     exon            481..594
                     /gene="USP22"
                     /gene_synonym="USP3L"
                     /inference="alignment:Splign:2.1.0"
     exon            595..696
                     /gene="USP22"
                     /gene_synonym="USP3L"
                     /inference="alignment:Splign:2.1.0"
     exon            697..866
                     /gene="USP22"
                     /gene_synonym="USP3L"
                     /inference="alignment:Splign:2.1.0"
     exon            867..1014
                     /gene="USP22"
                     /gene_synonym="USP3L"
                     /inference="alignment:Splign:2.1.0"
     exon            1015..1120
                     /gene="USP22"
                     /gene_synonym="USP3L"
                     /inference="alignment:Splign:2.1.0"
     exon            1121..1279
                     /gene="USP22"
                     /gene_synonym="USP3L"
                     /inference="alignment:Splign:2.1.0"
     exon            1280..1406
                     /gene="USP22"
                     /gene_synonym="USP3L"
                     /inference="alignment:Splign:2.1.0"
     exon            1407..1498
                     /gene="USP22"
                     /gene_synonym="USP3L"
                     /inference="alignment:Splign:2.1.0"
     exon            1499..1561
                     /gene="USP22"
                     /gene_synonym="USP3L"
                     /inference="alignment:Splign:2.1.0"
     exon            1562..1711
                     /gene="USP22"
                     /gene_synonym="USP3L"
                     /inference="alignment:Splign:2.1.0"
     exon            1712..5189
                     /gene="USP22"
                     /gene_synonym="USP3L"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      5029
                     /gene="USP22"
                     /gene_synonym="USP3L"
                     /note="major polyA site"
     regulatory      5031..5036
                     /regulatory_class="polyA_signal_sequence"
                     /gene="USP22"
                     /gene_synonym="USP3L"
                     /note="hexamer: AAGAAA"
     polyA_site      5046
                     /gene="USP22"
                     /gene_synonym="USP3L"
     regulatory      5168..5173
                     /regulatory_class="polyA_signal_sequence"
                     /gene="USP22"
                     /gene_synonym="USP3L"
                     /note="hexamer: AATAAA"
     polyA_site      5189
                     /gene="USP22"
                     /gene_synonym="USP3L"
                     /note="major polyA site"
ORIGIN      
        1 cttgcagcct cccctcggcg atcgcgcagc cccatctttg tccggcctcc gcgctttgtt
       61 ctcggcgccc gggccttggc cagcctggcc agccgccgag cagcccccac gccgcgctgg
      121 cgtcgtcctc gcctccctcg ccgccgcccc ccgcgcgcgg ccgggccttg ccccccatgg
      181 tgtcccggcc agagcccgag ggcgaggcca tggacgccga gctggcggta gcgccgccgg
      241 gctgctcgca cctgggcagc ttcaaggtgg acaactggaa gcagaacctg cgggccatct
      301 accagtgctt cgtgtggagc ggcacggctg aggcccgcaa gcgcaaggcc aagtcctgta
      361 tctgccatgt ctgtggcgtc cacctcaaca ggctgcattc ctgcctctac tgtgtcttct
      421 tcggctgttt cacaaagaag catattcacg agcatgcgaa ggcgaagcgg cacaacctgg
      481 ccattgatct gatgtacgga ggcatctact gttttctgtg ccaggactac atctatgaca
      541 aagacatgga aataatcgcc aaggaggagc agcgaaaagc ttggaaaatg caaggcgttg
      601 gagagaagtt ttcaacttgg gaaccaacca aacgggagct tgaactgctg aagcacaacc
      661 cgaaaaggag aaagatcacc tcgaactgca ccataggtct gcgtgggctg atcaaccttg
      721 ggaacacatg cttcatgaac tgcatcgtgc aggccctgac ccacacgcca cttctgcggg
      781 acttcttcct gtctgacagg caccgctgtg agatgcagag ccccagctcc tgtctggtct
      841 gtgagatgtc ctcactgttt caggagtttt actctggaca ccggtcccct cacatcccgt
      901 ataagttgct gcacctggtg tggacccacg cgaggcacct agcaggctac gagcagcagg
      961 acgcccacga gttcctcatc gcggccctgg acgtgctcca ccgacactgc aaaggtgatg
     1021 acaatgggaa gaaggccaac aaccccaacc actgcaactg catcatagac cagatcttca
     1081 caggcgggtt gcagtcagac gtcacctgcc aagtctgcca tggagtctcc accaccatcg
     1141 accccttctg ggacatcagc ttggatctcc ccggctcttc caccccattc tggcccctga
     1201 gcccagggag cgagggcaac gtggtaaacg gggaaagcca cgtgtcggga accaccacgc
     1261 tcacggactg cctgcgacga ttcaccagac cagagcactt gggcagcagc gccaagatca
     1321 agtgcagcgg ttgccatagc taccaggagt ccacaaagca gctcactatg aagaaactgc
     1381 ccatcgtagc ctgttttcat ctcaaacgat ttgaacactc agccaagctg cggcggaaga
     1441 tcaccacgta tgtgtccttc cccctggagc tggacatgac ccctttcatg gcctccagca
     1501 aagagagcag gatgaatgga cagtaccagc agcccacgga cagtctcaac aatgacaaca
     1561 agtattccct gtttgctgtt gttaaccatc aagggacctt ggagagtggc cactacacca
     1621 gctttatccg gcagcacaaa gaccagtggt tcaagtgtga cgatgccatc atcaccaagg
     1681 ccagcatcaa ggacgtcctg gacagcgaag ggtacttgct gttctatcac aaacagttcc
     1741 tggaatacga gtagccttat ctgcagctgg tcagaaaaac aaaggcaatg cattggcaag
     1801 cctcacaaag tgatcctccc tggccccccc ctcccccaag tctcccgccg cctccccggc
     1861 ctggtgacac cacctcccat gcagatgtgg cccctctgca cctgggaccc atcgggtcgg
     1921 gatggaccac acggacgggg aggctcctgg agctgctttg aagatggatg agatgagggg
     1981 tgtgctctgg gtgggaggag cagcgtacac ccgtcaccag aacatctctt gtgtcatgac
     2041 atgggggtgc aacgggggcc tcacagcaca gagtgaccgc tgcctggcgt tccccagcac
     2101 tcggtgtgga aaggccccta cctgctgtaa gattatgggt ccatgaaagc agtaagctgg
     2161 acacagaggt gtagtgtgcg ggacagaggg ccttgcagat gcctttctgt tggtgtttta
     2221 gtgttaaaat acggagagta tggaactctt cacctccatt ttctcagcgg ctgtgaagca
     2281 gcctcctagc ttcggaagta cggacactac gtcgcgtttt caagcgtgtc tgttctgcag
     2341 gtaacagcat caagctgcac gtggaagcat ctcgcggttt tctagaaaca ggcattttct
     2401 tatccctctc ccgctccttt ttccacaaag gtgaatttca taaatgtaat actagtaaag
     2461 tgaatgaatt actgagttta tacagaaatt taggtaactt ctcctttagt ctcaagagcg
     2521 agtcttgctt tttaatgggt gccgtttatg ttgctgcccg ccctgtgtgc ctggctcctc
     2581 tgggtgcctt ggtgtctgct ggtggctggc agtgggcgca gcggaggaga gttgtgctgc
     2641 agctcatacg gtgtgtctgt catctcagtc tggagtaaat gcagtgtctg ccggtgtctg
     2701 atgggttctg tccctcgtat tttctttgcc ttctatccca ttgcctggct accgctgcct
     2761 ggcagccaag ggtgttggtc gcgaagctgg agtggcctct ggtggagcct gcatcttgtc
     2821 tcgtctgcct ctgctttaca tttggtgtac tttcgggcgt ggtggcagta aaatgacacc
     2881 gtgattgagc ttgtcagcag agctgaaaga gaaagtagaa ggatgtgcat tgtttcttgt
     2941 aagatatctt gcatgtatct gtgtattcaa attcaaacag agatggtttg tccatttgtc
     3001 cactgagaaa ttagaaacta gggacaaggg ggaggaaaag tactgaaata cagtttatga
     3061 agcaagtgtg tctcgggctg tgcttgtccc aggagcccca gcagcatctg aactgaggct
     3121 tcttcagtcc tgcaggaaca ggatcatctg tctcagcggt gggcagatgt tttcatagac
     3181 agccagggag taaacactgt tggctctgtg ggctgtatgg tctctgccat aaatagtaca
     3241 gagatgtggc tgtgtctagt acaactttta gacacagaaa tctgaatgac atatattgtt
     3301 ctgtgtcaag aaacttagat ttttttttta actatttaaa aacgtgaaac ctattcttag
     3361 ctcacaggcc atggagaagc tggtggggac cagacccagc tccttagctg gctgggctgg
     3421 ggagggggta gtgacagtgg cagctgctac tcactgctca gtgtggaaaa cacaggactt
     3481 ggcaatcaca gcccgcagaa ccatcatgtg tggcagaagc ctgagggatg cggtttcttg
     3541 cccacgtgct ctgttcattt tctgttgttt ttctgcactt aaagaattca catggaagca
     3601 tgttttataa aatgaattac cagagaaaca gagatgggcc gagattttca gaaatggtcc
     3661 catgtgacca agttctgctg tttgggtgac agtgctttga agatctcctt tgaggatgtg
     3721 cagtcttttt tttttttttt ttgagatgga gtttgttgcc caggctggag tgagtggcac
     3781 agtctcggct cactgcaacc tccacctcct gggttcaagc agttctcgtg ccgcagcctc
     3841 ccaagtagct gggactacag gcatgcacca ccacgccagg ctaatttttg tatttttagt
     3901 agagatgggg tttcaccatg tctcaaactc ctgacctcag gcgatccacc cacctcagcg
     3961 tcccaaagtg ctgggattat aggcgtgagc caccgcacct ggcctatgag tggtctttta
     4021 attaggaaca aatctaatgg aaaggagagt tgactgaagt tggcccacag gattgtgagc
     4081 tgggcagtgc cttcatgaag gcttgccacc ttgggacgcc ccagtttact ggggtgtctt
     4141 gcggagtgca gaaggctttc tggcagctgc ctgggtttgg ccagaccctg cctcccctcc
     4201 cgccggccaa cccctagtcc ccttcctgtc tccacttgca ttcaggggtg gctgctgttc
     4261 tgagaacatt agaactggga agagagatgg agtcacatgg atttttggtg ggcattattc
     4321 taaactttcg tatccaagtt agtccccctt attccactgt ggcattgccg ttctaagcag
     4381 ttacctgatg cctgctgctg aagagctgct cacaggaggc ggcggcggcc ctggcactgc
     4441 cccttgcatt aggtcttgtg tttgatgtgt tcttgtgaat ttactttgtc agaacaaaat
     4501 atttacgcgt tgggttcagg aatttctttt agctccccat ctggctgtga aattcaggaa
     4561 acctcccgtt gcctagtaat caccccatgt aggtgtacat tgtgacaaag tgcatctgac
     4621 cactaagggg cccccttggt gaccccagca cattcacagc agtgttaaaa tggcctgcat
     4681 tttggagatg ctggctggcc tttcagtgcc tcccaggaag acacatggcc tttccctctt
     4741 cagatgcctg aagggagtgc tttgaggcag gtgatgtgct gggagtgtgg gcggcctccc
     4801 tctggccccg gggccctctg tggaccttgg ctccctccgt ggacctgggc ttcgtggtga
     4861 gcactgcagc ctccctgggc attccctcca gcgccagcac cactgcaaca tatagacctg
     4921 agtgctattg tattttggct tggtgtgtat gctcttcatt gtgtaaaatt gctgttcttt
     4981 tgacaattta agtgattgtt ttgtttactg taagtttgaa aataaaaatg aagaaaaaaa
     5041 ttccaatgac tgtgctgtgg ttggagactt tatttaccaa gatgtttact cttcctttcc
     5101 ccttccattt tgaggagctg tgtcactcct cctccccccc agtgctttgt agtctctcct
     5161 atgtcataat aaagctacat tttctctga
//
