LOCUS       NM_001110303            4293 bp    mRNA    linear   PRI 21-SEP-2024
DEFINITION  Homo sapiens ubiquitin specific peptidase 20 (USP20), transcript
            variant 3, mRNA.
ACCESSION   NM_001110303
VERSION     NM_001110303.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4293)
  AUTHORS   Zhang,L., Wu,J.H., Jean-Charles,P.Y., Murali,P., Zhang,W.,
            Jazic,A., Kaur,S., Nepliouev,I., Stiber,J.A., Snow,K.,
            Freedman,N.J. and Shenoy,S.K.
  TITLE     Phosphorylation of USP20 on Ser334 by IRAK1 promotes
            IL-1beta-evoked signaling in vascular smooth muscle cells and
            vascular inflammation
  JOURNAL   J Biol Chem 299 (7), 104911 (2023)
   PUBMED   37311534
  REMARK    GeneRIF: Phosphorylation of USP20 on Ser334 by IRAK1 promotes
            IL-1beta-evoked signaling in vascular smooth muscle cells and
            vascular inflammation.
REFERENCE   2  (bases 1 to 4293)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 4293)
  AUTHORS   Culver,J.A. and Mariappan,M.
  TITLE     Deubiquitinases USP20/33 promote the biogenesis of tail-anchored
            membrane proteins
  JOURNAL   J Cell Biol 220 (5) (2021)
   PUBMED   33792613
  REMARK    GeneRIF: Deubiquitinases USP20/33 promote the biogenesis of
            tail-anchored membrane proteins.
REFERENCE   4  (bases 1 to 4293)
  AUTHORS   Hu,S., Chen,X., Zhu,M., Hu,H., Zhou,C., Shi,L. and Zhang,N.
  TITLE     Expression, purification and characterization of the second DUSP
            domain of deubiquitinase USP20/VDU2
  JOURNAL   Protein Expr Purif 181, 105836 (2021)
   PUBMED   33529762
  REMARK    GeneRIF: Expression, purification and characterization of the
            second DUSP domain of deubiquitinase USP20/VDU2.
REFERENCE   5  (bases 1 to 4293)
  AUTHORS   Li,W., Shen,M., Jiang,Y.Z., Zhang,R., Zheng,H., Wei,Y., Shao,Z.M.
            and Kang,Y.
  TITLE     Deubiquitinase USP20 promotes breast cancer metastasis by
            stabilizing SNAI2
  JOURNAL   Genes Dev 34 (19-20), 1310-1315 (2020)
   PUBMED   32943575
  REMARK    GeneRIF: Deubiquitinase USP20 promotes breast cancer metastasis by
            stabilizing SNAI2.
REFERENCE   6  (bases 1 to 4293)
  AUTHORS   Li,Z., Wang,D., Messing,E.M. and Wu,G.
  TITLE     VHL protein-interacting deubiquitinating enzyme 2 deubiquitinates
            and stabilizes HIF-1alpha
  JOURNAL   EMBO Rep 6 (4), 373-378 (2005)
   PUBMED   15776016
  REMARK    GeneRIF: von Hippel-Lindau protein-interacting deubiquitinating
            enzyme 2 (VDU2) deubiquitinates and stabilizes HIF-1alpha.
REFERENCE   7  (bases 1 to 4293)
  AUTHORS   Curcio-Morelli,C., Zavacki,A.M., Christofollete,M., Gereben,B., de
            Freitas,B.C., Harney,J.W., Li,Z., Wu,G. and Bianco,A.C.
  TITLE     Deubiquitination of type 2 iodothyronine deiodinase by von
            Hippel-Lindau protein-interacting deubiquitinating enzymes
            regulates thyroid hormone activation
  JOURNAL   J Clin Invest 112 (2), 189-196 (2003)
   PUBMED   12865408
  REMARK    GeneRIF: identification and description of VDU2 in human cells
REFERENCE   8  (bases 1 to 4293)
  AUTHORS   Puente,X.S., Sanchez,L.M., Overall,C.M. and Lopez-Otin,C.
  TITLE     Human and mouse proteases: a comparative genomic approach
  JOURNAL   Nat Rev Genet 4 (7), 544-558 (2003)
   PUBMED   12838346
  REMARK    Review article
REFERENCE   9  (bases 1 to 4293)
  AUTHORS   Li,Z., Wang,D., Na,X., Schoen,S.R., Messing,E.M. and Wu,G.
  TITLE     Identification of a deubiquitinating enzyme subfamily as substrates
            of the von Hippel-Lindau tumor suppressor
  JOURNAL   Biochem Biophys Res Commun 294 (3), 700-709 (2002)
   PUBMED   12056827
REFERENCE   10 (bases 1 to 4293)
  AUTHORS   Gilley,J. and Fried,M.
  TITLE     Extensive gene order differences within regions of conserved
            synteny between the Fugu and human genomes: implications for
            chromosomal evolution and the cloning of disease genes
  JOURNAL   Hum Mol Genet 8 (7), 1313-1320 (1999)
   PUBMED   10369878
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL158207.15.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Jun 2, 2019 this sequence version replaced NM_001110303.3.
            
            Summary: This gene encodes a ubiquitin specific processing protease
            that was first identified as a substrate of the VHL (von
            Hippel-Lindau disease) protein E3 ubiquitin ligase complex. In
            addition to being ubiquitinated by the VHL-E3 ligase complex, this
            enzyme deubiquitinates hypoxia-inducible factor (HIF)-1 alpha and
            thereby causes increased expression of HIF-1alpha targeted genes
            which play a role in angiogenesis, glucose metabolism, cell
            proliferation and metastasis. The enzyme encoded by this gene also
            regulates G-protein coupled receptor signaling by mediating the
            deubiquitination of beta-2 adrenergic receptor (ADRB2). This enzyme
            is a ubiquitously expressed thiolester hydrolase. Alternative
            splicing results in multiple transcript variants encoding the same
            protein. [provided by RefSeq, Jan 2013].
            
            Transcript Variant: This variant (3) has a different 3' non-coding,
            terminal exon, compared to transcript variant 1. All three
            transcript variants encode the same protein.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The extent of this transcript is
            supported by transcript alignments and orthologous data.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7346977.1838115.1,
                                           SRR1803613.22163.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000372429.8/ ENSP00000361506.3
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-42                AL158207.15        36511-36552
            43-154              AL158207.15        50866-50977
            155-251             AL158207.15        53593-53689
            252-305             AL158207.15        57360-57413
            306-368             AL158207.15        59103-59165
            369-500             AL158207.15        59520-59651
            501-597             AL158207.15        61990-62086
            598-667             AL158207.15        62596-62665
            668-781             AL158207.15        64239-64352
            782-860             AL158207.15        66356-66434
            861-1305            AL158207.15        69058-69502
            1306-1446           AL158207.15        69915-70055
            1447-1562           AL158207.15        70363-70478
            1563-1735           AL158207.15        70725-70897
            1736-1830           AL158207.15        71506-71600
            1831-1864           AL158207.15        74535-74568
            1865-1910           AL158207.15        74752-74797
            1911-2091           AL158207.15        75629-75809
            2092-2218           AL158207.15        75882-76008
            2219-2388           AL158207.15        76363-76532
            2389-2470           AL158207.15        76613-76694
            2471-2579           AL158207.15        77183-77291
            2580-2682           AL158207.15        79391-79493
            2683-2754           AL158207.15        80626-80697
            2755-2931           AL158207.15        81166-81342
            2932-4293           AL158207.15        81520-82881
FEATURES             Location/Qualifiers
     source          1..4293
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9q34.11"
     gene            1..4293
                     /gene="USP20"
                     /gene_synonym="hVDU2; LSFR3A; VDU2"
                     /note="ubiquitin specific peptidase 20"
                     /db_xref="GeneID:10868"
                     /db_xref="HGNC:HGNC:12619"
                     /db_xref="MIM:615143"
     exon            1..42
                     /gene="USP20"
                     /gene_synonym="hVDU2; LSFR3A; VDU2"
                     /inference="alignment:Splign:2.1.0"
     exon            43..154
                     /gene="USP20"
                     /gene_synonym="hVDU2; LSFR3A; VDU2"
                     /inference="alignment:Splign:2.1.0"
     exon            155..251
                     /gene="USP20"
                     /gene_synonym="hVDU2; LSFR3A; VDU2"
                     /inference="alignment:Splign:2.1.0"
     CDS             171..2915
                     /gene="USP20"
                     /gene_synonym="hVDU2; LSFR3A; VDU2"
                     /EC_number="3.4.19.12"
                     /note="pVHL-interacting deubiquitinating enzyme 2;
                     ubiquitin thioesterase 20; deubiquitinating enzyme 20;
                     ubiquitin-specific-processing protease 20; ubiquitin
                     thiolesterase 20"
                     /codon_start=1
                     /product="ubiquitin carboxyl-terminal hydrolase 20"
                     /protein_id="NP_001103773.2"
                     /db_xref="CCDS:CCDS43892.1"
                     /db_xref="GeneID:10868"
                     /db_xref="HGNC:HGNC:12619"
                     /db_xref="MIM:615143"
                     /translation="MGDSRDLCPHLDSIGEVTKEDLLLKSKGTCQSCGVTGPNLWACL
                     QVACPYVGCGESFADHSTIHAQAKKHNLTVNLTTFRLWCYACEKEVFLEQRLAAPLLG
                     SSSKFSEQDSPPPSHPLKAVPIAVADEGESESEDDDLKPRGLTGMKNLGNSCYMNAAL
                     QALSNCPPLTQFFLECGGLVRTDKKPALCKSYQKLVSEVWHKKRPSYVVPTSLSHGIK
                     LVNPMFRGYAQQDTQEFLRCLMDQLHEELKEPVVATVALTEARDSDSSDTDEKREGDR
                     SPSEDEFLSCDSSSDRGEGDGQGRGGGSSQAETELLIPDEAGRAISEKERMKDRKFSW
                     GQQRTNSEQVDEDADVDTAMAALDDQPAEAQPPSPRSSSPCRTPEPDNDAHLRSSSRP
                     CSPVHHHEGHAKLSSSPPRASPVRMAPSYVLKKAQVLSAGSRRRKEQRYRSVISDIFD
                     GSILSLVQCLTCDRVSTTVETFQDLSLPIPGKEDLAKLHSAIYQNVPAKPGACGDSYA
                     AQGWLAFIVEYIRRFVVSCTPSWFWGPVVTLEDCLAAFFAADELKGDNMYSCERCKKL
                     RNGVKYCKVLRLPEILCIHLKRFRHEVMYSFKINSHVSFPLEGLDLRPFLAKECTSQI
                     TTYDLLSVICHHGTAGSGHYIAYCQNVINGQWYEFDDQYVTEVHETVVQNAEGYVLFY
                     RKSSEEAMRERQQVVSLAAMREPSLLRFYVSREWLNKFNTFAEPGPITNQTFLCSHGG
                     IPPHKYHYIDDLVVILPQNVWEHLYNRFGGGPAVNHLYVCSICQVEIEALAKRRRIEI
                     DTFIKLNKAFQAEESPGVIYCISMQWFREWEAFVKGKDNEPPGPIDNSRIAQVKGSGH
                     VQLKQGADYGQISEETWTYLNSLYGGGPEIAIRQSVAQPLGPENLHGEQKIEAETRAV
                     "
     exon            252..305
                     /gene="USP20"
                     /gene_synonym="hVDU2; LSFR3A; VDU2"
                     /inference="alignment:Splign:2.1.0"
     exon            306..368
                     /gene="USP20"
                     /gene_synonym="hVDU2; LSFR3A; VDU2"
                     /inference="alignment:Splign:2.1.0"
     exon            369..500
                     /gene="USP20"
                     /gene_synonym="hVDU2; LSFR3A; VDU2"
                     /inference="alignment:Splign:2.1.0"
     exon            501..597
                     /gene="USP20"
                     /gene_synonym="hVDU2; LSFR3A; VDU2"
                     /inference="alignment:Splign:2.1.0"
     exon            598..667
                     /gene="USP20"
                     /gene_synonym="hVDU2; LSFR3A; VDU2"
                     /inference="alignment:Splign:2.1.0"
     exon            668..781
                     /gene="USP20"
                     /gene_synonym="hVDU2; LSFR3A; VDU2"
                     /inference="alignment:Splign:2.1.0"
     exon            782..860
                     /gene="USP20"
                     /gene_synonym="hVDU2; LSFR3A; VDU2"
                     /inference="alignment:Splign:2.1.0"
     exon            861..1305
                     /gene="USP20"
                     /gene_synonym="hVDU2; LSFR3A; VDU2"
                     /inference="alignment:Splign:2.1.0"
     exon            1306..1446
                     /gene="USP20"
                     /gene_synonym="hVDU2; LSFR3A; VDU2"
                     /inference="alignment:Splign:2.1.0"
     exon            1447..1562
                     /gene="USP20"
                     /gene_synonym="hVDU2; LSFR3A; VDU2"
                     /inference="alignment:Splign:2.1.0"
     exon            1563..1735
                     /gene="USP20"
                     /gene_synonym="hVDU2; LSFR3A; VDU2"
                     /inference="alignment:Splign:2.1.0"
     exon            1736..1830
                     /gene="USP20"
                     /gene_synonym="hVDU2; LSFR3A; VDU2"
                     /inference="alignment:Splign:2.1.0"
     exon            1831..1864
                     /gene="USP20"
                     /gene_synonym="hVDU2; LSFR3A; VDU2"
                     /inference="alignment:Splign:2.1.0"
     exon            1865..1910
                     /gene="USP20"
                     /gene_synonym="hVDU2; LSFR3A; VDU2"
                     /inference="alignment:Splign:2.1.0"
     exon            1911..2091
                     /gene="USP20"
                     /gene_synonym="hVDU2; LSFR3A; VDU2"
                     /inference="alignment:Splign:2.1.0"
     exon            2092..2218
                     /gene="USP20"
                     /gene_synonym="hVDU2; LSFR3A; VDU2"
                     /inference="alignment:Splign:2.1.0"
     exon            2219..2388
                     /gene="USP20"
                     /gene_synonym="hVDU2; LSFR3A; VDU2"
                     /inference="alignment:Splign:2.1.0"
     exon            2389..2470
                     /gene="USP20"
                     /gene_synonym="hVDU2; LSFR3A; VDU2"
                     /inference="alignment:Splign:2.1.0"
     exon            2471..2579
                     /gene="USP20"
                     /gene_synonym="hVDU2; LSFR3A; VDU2"
                     /inference="alignment:Splign:2.1.0"
     exon            2580..2682
                     /gene="USP20"
                     /gene_synonym="hVDU2; LSFR3A; VDU2"
                     /inference="alignment:Splign:2.1.0"
     exon            2683..2754
                     /gene="USP20"
                     /gene_synonym="hVDU2; LSFR3A; VDU2"
                     /inference="alignment:Splign:2.1.0"
     exon            2755..2931
                     /gene="USP20"
                     /gene_synonym="hVDU2; LSFR3A; VDU2"
                     /inference="alignment:Splign:2.1.0"
     exon            2932..4293
                     /gene="USP20"
                     /gene_synonym="hVDU2; LSFR3A; VDU2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4273..4278
                     /regulatory_class="polyA_signal_sequence"
                     /gene="USP20"
                     /gene_synonym="hVDU2; LSFR3A; VDU2"
                     /note="hexamer: AATAAA"
     polyA_site      4293
                     /gene="USP20"
                     /gene_synonym="hVDU2; LSFR3A; VDU2"
                     /note="major polyA site"
ORIGIN      
        1 gcgcttgact gacaggcggc ggcggcgcag ttgcgagtgc aggctccttg ccagaggcct
       61 ccactcactc cagaccccta tagcccgtcg ctgtcagctg tcaacaaagg atgcgaatgc
      121 tggccgcttc ctgtgggctt cgtgtcaccc agaggtgagc ccaggccagg atgggggact
      181 ccagggacct ttgccctcac cttgactcca taggagaggt gaccaaagag gacttgctgc
      241 tcaaatctaa gggaacctgt cagtcgtgtg gggtcaccgg accaaaccta tgggcctgtc
      301 tgcaggttgc ctgcccctat gttggctgcg gagaatcctt tgctgaccac agcaccattc
      361 atgcacaggc aaaaaagcac aacttgaccg tgaacctgac cacgttccga ctgtggtgtt
      421 acgcctgtga gaaggaggta ttcctggagc agcggctggc agcccctctg ctgggctcct
      481 cttccaagtt ctctgaacag gactccccgc caccctccca ccctctgaaa gctgttccta
      541 ttgctgtggc tgatgaagga gagtctgagt cagaggacga tgacctgaaa cctcgaggcc
      601 tcacgggcat gaagaacctc gggaactcct gctacatgaa cgctgccctg caggccctgt
      661 ccaattgccc gccgctgact cagttcttct tggagtgtgg cggcctggtg cgcacagata
      721 agaagccagc cctgtgcaag agctaccaga agctggtctc tgaggtctgg cataagaaac
      781 ggccaagcta cgtggtcccc accagtctgt ctcatgggat caagttggtc aacccaatgt
      841 tccgaggcta tgcccagcag gacacccaag agttccttcg ctgcctgatg gaccagctgc
      901 acgaggagct caaggagccg gtggtggcca cggtggcgct gacggaggct cgggactcag
      961 attcgagtga cacggatgag aaacgggagg gtgaccggag cccatcagaa gatgagttct
     1021 tgtcctgtga ctcgagcagt gaccggggtg agggtgacgg gcaggggcgt ggcgggggca
     1081 gctcgcaggc cgagacggag ctgctgatcc cagatgaggc gggccgagcc atctctgaga
     1141 aggagcggat gaaggaccgc aagttctcct ggggccagca gcgtacaaac tcggagcaag
     1201 tggacgagga cgctgatgtg gacactgcca tggctgccct tgacgaccag cccgcggagg
     1261 cccagccccc gtcaccacgg tcctccagcc cctgccggac gccagagccg gacaatgatg
     1321 ctcacctacg cagctcctct cgcccctgca gccccgtcca ccaccacgag ggccatgcca
     1381 agctgtctag cagcccccct cgtgcaagcc ccgtgaggat ggcaccgtcg tacgtgctca
     1441 agaaagccca ggtattgagt gctggcagcc ggaggcggaa ggagcagcgc taccgcagcg
     1501 tcatctcaga catctttgac ggctccattc tcagccttgt gcagtgtctc acctgtgacc
     1561 gggtatccac cacagtggaa acgttccagg acttatcact gcccattcct ggaaaggagg
     1621 acctggccaa gctccattca gccatctacc agaatgtgcc ggccaagcca ggcgcctgtg
     1681 gggacagcta tgccgcccag ggctggctgg ccttcattgt ggagtacatc cgacggtttg
     1741 tggtatcctg tacccccagc tggttttggg ggcctgtcgt caccctggaa gactgccttg
     1801 ctgccttctt tgccgctgat gagttaaagg gtgacaacat gtacagctgt gagcggtgta
     1861 agaagctgcg gaacggagtg aagtactgca aagtcctgcg gttgcccgag atcctgtgca
     1921 ttcacctaaa gcgctttcgg cacgaggtga tgtactcatt caagatcaac agccacgtct
     1981 ccttccccct cgaggggctc gacctgcgcc ccttccttgc caaggagtgc acatcccaga
     2041 tcaccaccta cgacctcctc tcggtcatct gccaccacgg cacggcaggc agtgggcact
     2101 acatcgccta ctgccagaac gtgatcaatg ggcagtggta cgagtttgat gaccagtacg
     2161 tcacagaagt ccacgagacg gtggtgcaga acgccgaggg ctacgtactc ttctacagga
     2221 agagcagcga ggaggccatg cgggagcgac agcaggtggt gtccctggcc gccatgcggg
     2281 agcccagcct gctgcggttc tacgtgtccc gcgagtggct caacaagttc aacaccttcg
     2341 cggagccagg ccccatcacc aaccagacct tcctctgctc ccacggaggc atcccgcccc
     2401 acaaatacca ctacatcgac gacctggtgg tcatcctgcc ccagaacgtc tgggagcacc
     2461 tgtacaacag attcgggggt ggccccgccg tgaaccacct gtacgtgtgc tccatctgcc
     2521 aggtggagat cgaggcactg gccaagcgca ggaggatcga gatcgacacc ttcatcaagt
     2581 tgaacaaggc cttccaggcc gaggagtcgc cgggcgtcat ctactgcatc agcatgcagt
     2641 ggttccggga gtgggaggcg ttcgtcaagg ggaaggacaa cgagcccccc gggcccattg
     2701 acaacagcag gattgcacag gtcaaaggaa gcggccatgt ccagctgaag cagggagctg
     2761 actacgggca gatttcggag gagacctgga cctacctgaa cagcctgtat ggaggtggcc
     2821 ccgagattgc catccgccag agtgtggcgc agccgctggg cccagagaac ctgcacgggg
     2881 agcagaagat cgaagccgag acgcgggccg tgtgatctgc tgggctagtc tccccatgtg
     2941 ccccaccccg cggaaggcgt gtttgtgccc agaagagagg ccgggctgct gcagaacccc
     3001 gccgtgtaaa gaggcagaaa agttggtttg gtttgcagta acgctgcaac tagaaaatat
     3061 atgcacttca ggcttgttga aacgaccaag actctgtgac gttaatttgg gtctttgtcc
     3121 tggcagtgcc tctgccagtc actgtcatcg ttgtgtcccc cacaactgtc ctcttgctag
     3181 ctcggcccag ctttgtccct ggagcccgat gctacccctg tcagacagag gctgcggcct
     3241 gggccagagt cagggagtag ctgctgcttc acggcgtctc cactgtgcga ttggcccgga
     3301 gccccgaaga ctcggaggga gctgctcagg gccggtgagc gcagccagaa gccctggcca
     3361 gtgaggagct cacaggtcct ccctggtggt cccgccgcac ctctgcatct cctgggcgtc
     3421 accaggaagg ctctgaagtc ccgggctgct ctcagcactt ctcctgcaga ctgaagactc
     3481 tggactcatt gctgattgga acaccaggag gaggttggat ttctgccagt gggggatgtt
     3541 tctggaggca gctggtcccc cacaccgcgt cctgctgagc ctgccccctg gattggctgt
     3601 aatttgcctc gaagttcagc agttcatctt catgggaaat ttgctgagcc cccaccaggg
     3661 aaccggatga tgaaacaggg atacctcaca gcttggccat ttgaggcaaa ggcagcttcc
     3721 cgagctgatg ctaaagaaga cagactttcc cttcctccca gcagcagcag tgcagagccc
     3781 acctggaggg atgtgggggc tgtgcagggt gcagcgctca ggtggatcct gggaagcagc
     3841 ctctggatgc tgagtggagg gagccactga gcacagcaag gcaccaaagc ccctggagaa
     3901 accgccaggg cgaggtgcga ccatcatcag gatcaaagca gacggggcgt gggtggggaa
     3961 ggggctctgg gaccagaccc cccacactac tgcgtctttg tttctatcag tctttgtaga
     4021 agcaggtggt ggtggaaatt ccagcaggtg ggtcccgcag aggccctgag gcctcacttt
     4081 tcggatcttc tgtcccagat cctgctccct ccctgctgag cctggggttc ccctggcatt
     4141 ggccccagcc ttctgaaagc cggcgctgca gccagaggcc gcacgctgca ctgtcgcgac
     4201 gcagagaggc ttctgtgcag gctgggatcg ggccccatgt ctgtgctgtc tagtttgtgt
     4261 tcaaaatgtc agaataaaca cagaataaat gtt
//
