LOCUS       NM_004205               3697 bp    mRNA    linear   PRI 03-APR-2024
DEFINITION  Homo sapiens ubiquitin specific peptidase 2 (USP2), transcript
            variant 1, mRNA.
ACCESSION   NM_004205
VERSION     NM_004205.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3697)
  AUTHORS   Cheng,Q., Chen,M., Liu,M., Wang,F., Chen,X., Sun,W., Du,Y. and
            Wu,H.
  TITLE     Age-related genes USP2 and ARG2 are involved in the reduction of
            immune cell infiltration in elderly patients with rheumatoid
            arthritis
  JOURNAL   J Gene Med 26 (1), e3582 (2024)
   PUBMED   37727011
  REMARK    GeneRIF: Age-related genes USP2 and ARG2 are involved in the
            reduction of immune cell infiltration in elderly patients with
            rheumatoid arthritis.
REFERENCE   2  (bases 1 to 3697)
  AUTHORS   Zhu,L., Chen,Z., Guo,T., Chen,W., Zhao,L., Guo,L. and Pan,X.
  TITLE     USP2 Inhibits Lung Cancer Pathogenesis by Reducing ARID2 Protein
            Degradation via Ubiquitination
  JOURNAL   Biomed Res Int 2022, 1525216 (2022)
   PUBMED   36567903
  REMARK    GeneRIF: USP2 Inhibits Lung Cancer Pathogenesis by Reducing ARID2
            Protein Degradation via Ubiquitination.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3697)
  AUTHORS   Hashimoto,M., Fujimoto,M., Konno,K., Lee,M.L., Yamada,Y.,
            Yamashita,K., Toda,C., Tomura,M., Watanabe,M., Inanami,O. and
            Kitamura,H.
  TITLE     Ubiquitin-Specific Protease 2 in the Ventromedial Hypothalamus
            Modifies Blood Glucose Levels by Controlling Sympathetic Nervous
            Activation
  JOURNAL   J Neurosci 42 (23), 4607-4618 (2022)
   PUBMED   35504726
  REMARK    GeneRIF: Ubiquitin-Specific Protease 2 in the Ventromedial
            Hypothalamus Modifies Blood Glucose Levels by Controlling
            Sympathetic Nervous Activation.
REFERENCE   4  (bases 1 to 3697)
  AUTHORS   Ke,H.L., Lee,Y.C., Li,W.M., Wang,C.S., Hsu,W.C., Lin,H.H.,
            Lee,Y.A., Jhan,J.H., Li,C.C., Yeh,H.C., Wu,W.J. and Huang,A.M.
  TITLE     High Ubiquitin-Specific Protease 2a Expression Level Predicts Poor
            Prognosis in Upper Tract Urothelial Carcinoma
  JOURNAL   Appl Immunohistochem Mol Morphol 30 (4), 304-310 (2022)
   PUBMED   35384881
  REMARK    GeneRIF: High Ubiquitin-Specific Protease 2a Expression Level
            Predicts Poor Prognosis in Upper Tract Urothelial Carcinoma.
REFERENCE   5  (bases 1 to 3697)
  AUTHORS   Tu,Y., Xu,L., Xu,J., Bao,Z., Tian,W., Ye,Y., Sun,G., Miao,Z.,
            Chao,H., You,Y., Liu,N. and Ji,J.
  TITLE     Loss of deubiquitylase USP2 triggers development of glioblastoma
            via TGF-beta signaling
  JOURNAL   Oncogene 41 (18), 2597-2608 (2022)
   PUBMED   35332268
  REMARK    GeneRIF: Loss of deubiquitylase USP2 triggers development of
            glioblastoma via TGF-beta signaling.
REFERENCE   6  (bases 1 to 3697)
  AUTHORS   Bouwmeester,T., Bauch,A., Ruffner,H., Angrand,P.O., Bergamini,G.,
            Croughton,K., Cruciat,C., Eberhard,D., Gagneur,J., Ghidelli,S.,
            Hopf,C., Huhse,B., Mangano,R., Michon,A.M., Schirle,M., Schlegl,J.,
            Schwab,M., Stein,M.A., Bauer,A., Casari,G., Drewes,G., Gavin,A.C.,
            Jackson,D.B., Joberty,G., Neubauer,G., Rick,J., Kuster,B. and
            Superti-Furga,G.
  TITLE     A physical and functional map of the human TNF-alpha/NF-kappa B
            signal transduction pathway
  JOURNAL   Nat Cell Biol 6 (2), 97-105 (2004)
   PUBMED   14743216
  REMARK    Erratum:[Nat Cell Biol. 2004 May;6(5):465]
REFERENCE   7  (bases 1 to 3697)
  AUTHORS   Puente,X.S., Sanchez,L.M., Overall,C.M. and Lopez-Otin,C.
  TITLE     Human and mouse proteases: a comparative genomic approach
  JOURNAL   Nat Rev Genet 4 (7), 544-558 (2003)
   PUBMED   12838346
  REMARK    Review article
REFERENCE   8  (bases 1 to 3697)
  AUTHORS   Gewies,A. and Grimm,S.
  TITLE     UBP41 is a proapoptotic ubiquitin-specific protease
  JOURNAL   Cancer Res 63 (3), 682-688 (2003)
   PUBMED   12566314
  REMARK    GeneRIF: Overexpression of Ubp41 is sufficient to elicit all
            features of apoptosis in human cells.
REFERENCE   9  (bases 1 to 3697)
  AUTHORS   D'Andrea,A. and Pellman,D.
  TITLE     Deubiquitinating enzymes: a new class of biological regulators
  JOURNAL   Crit Rev Biochem Mol Biol 33 (5), 337-352 (1998)
   PUBMED   9827704
  REMARK    Review article
REFERENCE   10 (bases 1 to 3697)
  AUTHORS   Baek,S.H., Choi,K.S., Yoo,Y.J., Cho,J.M., Baker,R.T., Tanaka,K. and
            Chung,C.H.
  TITLE     Molecular cloning of a novel ubiquitin-specific protease, UBP41,
            with isopeptidase activity in chick skeletal muscle
  JOURNAL   J Biol Chem 272 (41), 25560-25565 (1997)
   PUBMED   9325273
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DB098786.1, DB065104.1,
            BC002955.1, BC041366.2, AK057225.1 and AI806430.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_004205.4.
            
            Summary: This gene encodes a member of the family of
            de-ubiquitinating enzymes, which belongs to the peptidase C19
            superfamily. The encoded protein is a ubiquitin-specific protease
            which is required for TNF-alpha (tumor necrosis factor alpha)
            -induced NF-kB (nuclear factor kB) signaling. This protein
            deubiquitinates polyubiquitinated target proteins such as fatty
            acid synthase, murine double minute 2 (MDM2), MDM4/MDMX and cyclin
            D1. MDM2 and MDM4 are negative regulators of the p53 tumor
            suppressor and cyclin D1 is required for cell cycle G1/S
            transition. Multiple alternatively spliced transcript variants
            encoding different isoforms have been identified. [provided by
            RefSeq, Aug 2011].
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR11853559.7015.1,
                                           SRR18074969.1199334.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1968540,
                                           SAMEA1968968 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000260187.7/ ENSP00000260187.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-201               DB098786.1         37-237
            202-521             DB065104.1         216-535
            522-1296            BC002955.1         439-1213
            1297-2377           BC041366.2         503-1583
            2378-2639           AK057225.1         2343-2604
            2640-2695           AI806430.1         8-63                c
            2696-2850           BC041366.2         1901-2055
            2851-3697           BC041366.2         2057-2903
FEATURES             Location/Qualifiers
     source          1..3697
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q23.3"
     gene            1..3697
                     /gene="USP2"
                     /gene_synonym="UBP41; USP9"
                     /note="ubiquitin specific peptidase 2"
                     /db_xref="GeneID:9099"
                     /db_xref="HGNC:HGNC:12618"
                     /db_xref="MIM:604725"
     exon            1..218
                     /gene="USP2"
                     /gene_synonym="UBP41; USP9"
                     /inference="alignment:Splign:2.1.0"
     exon            219..1033
                     /gene="USP2"
                     /gene_synonym="UBP41; USP9"
                     /inference="alignment:Splign:2.1.0"
     CDS             260..2077
                     /gene="USP2"
                     /gene_synonym="UBP41; USP9"
                     /EC_number="3.4.19.12"
                     /note="isoform a is encoded by transcript variant 1;
                     ubiquitin specific protease 12; ubiquitin
                     carboxyl-terminal hydrolase 2; ubiquitin specific protease
                     9; ubiquitin thioesterase 2; deubiquitinating enzyme 2; 41
                     kDa ubiquitin-specific protease;
                     ubiquitin-specific-processing protease 2"
                     /codon_start=1
                     /product="ubiquitin carboxyl-terminal hydrolase 2 isoform
                     a"
                     /protein_id="NP_004196.4"
                     /db_xref="CCDS:CCDS8422.1"
                     /db_xref="GeneID:9099"
                     /db_xref="HGNC:HGNC:12618"
                     /db_xref="MIM:604725"
                     /translation="MSQLSSTLKRYTESARYTDAHYAKSGYGAYTPSSYGANLAASLL
                     EKEKLGFKPVPTSSFLTRPRTYGPSSLLDYDRGRPLLRPDITGGGKRAESQTRGTERP
                     LGSGLSGGSGFPYGVTNNCLSYLPINAYDQGVTLTQKLDSQSDLARDFSSLRTSDSYR
                     IDPRNLGRSPMLARTRKELCTLQGLYQTASCPEYLVDYLENYGRKGSASQVPSQAPPS
                     RVPEIISPTYRPIGRYTLWETGKGQAPGPSRSSSPGRDGMNSKSAQGLAGLRNLGNTC
                     FMNSILQCLSNTRELRDYCLQRLYMRDLHHGSNAHTALVEEFAKLIQTIWTSSPNDVV
                     SPSEFKTQIQRYAPRFVGYNQQDAQEFLRFLLDGLHNEVNRVTLRPKSNPENLDHLPD
                     DEKGRQMWRKYLEREDSRIGDLFVGQLKSSLTCTDCGYCSTVFDPFWDLSLPIAKRGY
                     PEVTLMDCMRLFTKEDVLDGDEKPTCCRCRGRKRCIKKFSIQRFPKILVLHLKRFSES
                     RIRTSKLTTFVNFPLRDLDLREFASENTNHAVYNLYAVSNHSGTTMGGHYTAYCRSPG
                     TGEWHTFNDSSVTPMSSSQVRTSDAYLLFYELASPPSRM"
     exon            1034..1084
                     /gene="USP2"
                     /gene_synonym="UBP41; USP9"
                     /inference="alignment:Splign:2.1.0"
     exon            1085..1208
                     /gene="USP2"
                     /gene_synonym="UBP41; USP9"
                     /inference="alignment:Splign:2.1.0"
     exon            1209..1320
                     /gene="USP2"
                     /gene_synonym="UBP41; USP9"
                     /inference="alignment:Splign:2.1.0"
     exon            1321..1431
                     /gene="USP2"
                     /gene_synonym="UBP41; USP9"
                     /inference="alignment:Splign:2.1.0"
     exon            1432..1496
                     /gene="USP2"
                     /gene_synonym="UBP41; USP9"
                     /inference="alignment:Splign:2.1.0"
     exon            1497..1600
                     /gene="USP2"
                     /gene_synonym="UBP41; USP9"
                     /inference="alignment:Splign:2.1.0"
     exon            1601..1681
                     /gene="USP2"
                     /gene_synonym="UBP41; USP9"
                     /inference="alignment:Splign:2.1.0"
     exon            1682..1760
                     /gene="USP2"
                     /gene_synonym="UBP41; USP9"
                     /inference="alignment:Splign:2.1.0"
     exon            1761..1868
                     /gene="USP2"
                     /gene_synonym="UBP41; USP9"
                     /inference="alignment:Splign:2.1.0"
     exon            1869..1989
                     /gene="USP2"
                     /gene_synonym="UBP41; USP9"
                     /inference="alignment:Splign:2.1.0"
     exon            1990..3697
                     /gene="USP2"
                     /gene_synonym="UBP41; USP9"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3677..3682
                     /regulatory_class="polyA_signal_sequence"
                     /gene="USP2"
                     /gene_synonym="UBP41; USP9"
                     /note="hexamer: AATAAT"
     polyA_site      3697
                     /gene="USP2"
                     /gene_synonym="UBP41; USP9"
                     /note="major polyA site"
ORIGIN      
        1 aggcgcgatg aggcggctgc ccgctgggtg gcgccgattt cccggggagg tcccttctgg
       61 gcccccggcg gaggtgggag agagtcaggc aggagccgag gccggggagc cctcttcgtc
      121 agctggtgct cactgcgccg cgccagcgcc agccgggact cacccgcagc tccatgcttg
      181 tgcccggttc gactcgtcca tactccaaga agaggcagcc catgaggctc ccagtcccca
      241 ctgagtgcca ccctgaagga tgtcccagct ctcctccacc ctgaagcgct acacagaatc
      301 ggcccgctac acagatgccc actatgccaa gtcgggctat ggtgcctaca ccccgtcctc
      361 ctatggggcc aatctggctg cctccttact ggagaaggag aaacttggtt tcaagccggt
      421 ccccaccagc agcttcctca cccgtccccg tacctatggc ccctcctccc tcctggacta
      481 tgaccggggc cgccccctgc tgagacccga catcactggg ggtggtaagc gggcagagag
      541 ccagacccgg ggtactgagc ggcctttagg cagtggcctc agcgggggca gcggattccc
      601 ttatggagtg accaacaact gcctcagcta cctgcccatc aatgcctatg accagggggt
      661 gaccctaacc cagaagctgg acagccaatc agacctggcc cgggatttct ccagcctccg
      721 gacctcagat agctaccgga tagaccccag gaacctgggc cgcagcccca tgctggcccg
      781 gacgcgcaag gagctctgca ccctgcaggg gctctaccag acagccagct gccctgaata
      841 cctggtcgac tacctggaga actatggtcg caagggcagt gcatctcagg tgccctccca
      901 ggcccctccc tcacgagtcc ctgaaatcat cagcccaacc taccgaccca ttggccgcta
      961 cacgctgtgg gagacgggaa agggtcaggc ccctgggccc agccgctcca gctccccggg
     1021 aagagacggc atgaattcta agagtgccca gggtctggct ggtcttcgaa accttgggaa
     1081 cacgtgcttc atgaactcaa ttctgcagtg cctgagcaac actcgggagt tgagagatta
     1141 ctgcctccag aggctctaca tgcgggacct gcaccacggc agcaatgcac acacagccct
     1201 cgtggaagag tttgcaaaac taattcagac catatggact tcatccccca atgatgtggt
     1261 gagcccatct gagttcaaga cccagatcca gagatacgca ccgcgctttg ttggctataa
     1321 tcagcaggat gctcaggagt tccttcgctt tcttctggat gggctccata acgaggtgaa
     1381 ccgagtgaca ctgagaccta agtccaaccc tgagaacctc gatcatcttc ctgatgacga
     1441 gaaaggccga cagatgtgga gaaaatatct agaacgggaa gacagtagga tcggggatct
     1501 ctttgttggg cagctaaaga gctcgctgac gtgtacagat tgtggttact gttctacggt
     1561 cttcgacccc ttctgggacc tctcactgcc cattgctaag cgaggttatc ctgaggtgac
     1621 attaatggac tgcatgaggc tcttcaccaa agaggatgtg cttgatggag atgaaaagcc
     1681 aacatgctgt cgctgccgag gcagaaaacg gtgtataaag aagttctcca tccagaggtt
     1741 cccaaagatc ttggtgctcc atctgaagcg gttctcagaa tccaggatcc gaaccagcaa
     1801 gctcacaaca tttgtgaact tccccctaag agacctggac ttaagagaat ttgcctcaga
     1861 aaacaccaac catgctgttt acaacctgta cgctgtgtcc aatcactccg gaaccaccat
     1921 gggtggccac tatacagcct actgtcgcag tccagggaca ggagaatggc acactttcaa
     1981 cgactccagc gtcactccca tgtcctccag ccaagtgcgc accagcgacg cctacctgct
     2041 cttctacgaa ctggccagcc cgccctcccg aatgtagcgc caggagccac gtcccttctc
     2101 ccttccccgt ggtggccccg ctccctaaat tttttaaaaa gacaaaaaca aaacaacaac
     2161 aacaacacac aaacctgaca agagaaaaac aaacctgaag ctgccgagca ggagtggatg
     2221 cagcctgatc agggtctgga gcaaggagcc gggctttcct gagctgtggc ccggcaggga
     2281 agatcgcctg gacgtggagc cagcatcgcc ccgtgccctc ggcgtttgca tttgtaaact
     2341 tgtggtcttc ctatgtgtca gaaacaactg tgtcttgggg gggaagaccc tcgctgcgcc
     2401 gcttcccgcc gcagcgcccg cgcctccgag gggacagcgc cctctggagc tcgctgggag
     2461 catcaccgcc tggacgcccg cgccgcggag gagccggcgc ccatctccac ccgcacggct
     2521 cgccggtcca gagccatgag ccaagagccc tcttcacgct gctaactcca ggggacagac
     2581 gaagggacat ctttggaaaa cgctggtttt ggtttttaaa aagcccaact tttttttttt
     2641 aatttccata actaaagtgt tcagactgga gtgctctcct tcaggcctct tcatagctgg
     2701 gacgttgcac tggtcctttt attgcttttc caagtacaac tttctaatgc tagccctccg
     2761 tggtgctagg tgggcgttgg ccaggcccca agcacagcca cagtagacct gggatctaaa
     2821 acaagtttct gttttggggg tttgggtttt tttttttttt ttttaatgtt ttgaatggaa
     2881 tttagttgcc tccaagaatt gtgccttata gcatttgggg accagggggt aactgcccct
     2941 cctgaaatat ccctcagcct cttccctttt ccccagtgct ctgttcaaac ccgcctggga
     3001 aagggatcct gcccttagcc ctggctcgtt gtgcattgca gtgaggcaaa gaagaaagca
     3061 ggtagattcc ttccgacagg gcatcaagtt cttcccgccc acgtcctcta gcccacccct
     3121 ggtctgctcc ccagctgttt gaaggatagc acaagcccct cgtccctaga gcttctctcc
     3181 cttttattta ttctcttaac atccctttcc ccctggcctt cctgcccccg cccccttctc
     3241 agagcctcct agacaatagg ccctttggac cgagtttctc agggatgccc aggccacccc
     3301 tcagctcttc ttagcgctgg tctccagtcc tgccctggga gctggagcct gggtatttgg
     3361 ggacatcttg cctcagttgt atggttcttt cctgtgggct caattttgcc ctacatagtt
     3421 ggataaaact ctgtgctgtc ctggagagta aagctgttca cccacacagc tgggcccggc
     3481 ttgtgccccg tggagcctgg cacattccag gctcctagga ggaggcatca gagaaagaca
     3541 ccctgagttt tactggcctg acacccttct ccagagaaga cctgtgaacc tgagcccaag
     3601 ggcaagtgta cacttgttta ctgtgtaagc aagagtagaa gaatgtctaa tgtacagtgg
     3661 aaccttgtac agaataaata atagctttga gaaatca
//
