LOCUS       NM_001400297            4964 bp    mRNA    linear   PRI 17-SEP-2024
DEFINITION  Homo sapiens ubiquitin specific peptidase 19 (USP19), transcript
            variant 38, mRNA.
ACCESSION   NM_001400297
VERSION     NM_001400297.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4964)
  AUTHORS   Yu,W., Zhuang,S., Zhan,M., Chen,Y., Zhang,J., Chen,L., Tu,C.,
            Zheng,L. and Chen,S.
  TITLE     Deubiquitinating Enzyme USP19 Regulates Ferroptosis and
            Mitochondrial Damage in SH-SY5Y Cells by Targeting the NOX4 Protein
  JOURNAL   J Alzheimers Dis 100 (3), 799-808 (2024)
   PUBMED   38943386
  REMARK    GeneRIF: Deubiquitinating Enzyme USP19 Regulates Ferroptosis and
            Mitochondrial Damage in SH-SY5Y Cells by Targeting the NOX4
            Protein.
REFERENCE   2  (bases 1 to 4964)
  AUTHORS   Tian,Z., Xu,C., He,W., Lin,Z., Zhang,W., Tao,K., Ding,R., Zhang,X.
            and Dou,K.
  TITLE     The deubiquitinating enzyme USP19 facilitates hepatocellular
            carcinoma progression through stabilizing YAP
  JOURNAL   Cancer Lett 577, 216439 (2023)
   PUBMED   37832781
  REMARK    GeneRIF: The deubiquitinating enzyme USP19 facilitates
            hepatocellular carcinoma progression through stabilizing YAP.
REFERENCE   3  (bases 1 to 4964)
  AUTHORS   Zhang,J., van Dinther,M., Thorikay,M., Gourabi,B.M.,
            Kruithof,B.P.T. and Ten Dijke,P.
  TITLE     Opposing USP19 splice variants in TGF-beta signaling and
            TGF-beta-induced epithelial-mesenchymal transition of breast cancer
            cells
  JOURNAL   Cell Mol Life Sci 80 (2), 43 (2023)
   PUBMED   36646950
  REMARK    GeneRIF: Opposing USP19 splice variants in TGF-beta signaling and
            TGF-beta-induced epithelial-mesenchymal transition of breast cancer
            cells.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4964)
  AUTHORS   Sarodaya,N., Tyagi,A., Kim,H.J., Kang,J.S., Singh,V., Hong,S.H.,
            Kim,W.J., Kim,K.S. and Ramakrishna,S.
  TITLE     Deubiquitinase USP19 extends the residual enzymatic activity of
            phenylalanine hydroxylase variants
  JOURNAL   Sci Rep 12 (1), 14243 (2022)
   PUBMED   35987969
  REMARK    GeneRIF: Deubiquitinase USP19 extends the residual enzymatic
            activity of phenylalanine hydroxylase variants.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4964)
  AUTHORS   Chevalier,B., Baatallah,N., Najm,M., Castanier,S., Jung,V.,
            Pranke,I., Golec,A., Stoven,V., Marullo,S., Antigny,F.,
            Guerrera,I.C., Sermet-Gaudelus,I., Edelman,A. and Hinzpeter,A.
  TITLE     Differential CFTR-Interactome Proximity Labeling Procedures
            Identify Enrichment in Multiple SLC Transporters
  JOURNAL   Int J Mol Sci 23 (16), 8937 (2022)
   PUBMED   36012204
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4964)
  AUTHORS   Mei,Y., Hahn,A.A., Hu,S. and Yang,X.
  TITLE     The USP19 deubiquitinase regulates the stability of c-IAP1 and
            c-IAP2
  JOURNAL   J Biol Chem 286 (41), 35380-35387 (2011)
   PUBMED   21849505
  REMARK    GeneRIF: The USP19 deubiquitinase regulates the stability of c-IAP1
            and c-IAP2.
REFERENCE   7  (bases 1 to 4964)
  AUTHORS   Lu,Y., Bedard,N., Chevalier,S. and Wing,S.S.
  TITLE     Identification of distinctive patterns of USP19-mediated growth
            regulation in normal and malignant cells
  JOURNAL   PLoS One 6 (1), e15936 (2011)
   PUBMED   21264218
  REMARK    GeneRIF: ability of USP19 to regulate cell proliferation and
            p27(Kip1) levels; complete loss of USP19 function on cell growth
            may arise as a result of oncogenic transformation of cells.
            Publication Status: Online-Only
REFERENCE   8  (bases 1 to 4964)
  AUTHORS   Hassink,G.C., Zhao,B., Sompallae,R., Altun,M., Gastaldello,S.,
            Zinin,N.V., Masucci,M.G. and Lindsten,K.
  TITLE     The ER-resident ubiquitin-specific protease 19 participates in the
            UPR and rescues ERAD substrates
  JOURNAL   EMBO Rep 10 (7), 755-761 (2009)
   PUBMED   19465887
  REMARK    GeneRIF: USP19 is the first example of a membrane-anchored
            deubiquitinating enzymes involved in the turnover of
            endoplasmic-reticulum-associated degradation substrates.
REFERENCE   9  (bases 1 to 4964)
  AUTHORS   Beausoleil,S.A., Jedrychowski,M., Schwartz,D., Elias,J.E.,
            Villen,J., Li,J., Cohn,M.A., Cantley,L.C. and Gygi,S.P.
  TITLE     Large-scale characterization of HeLa cell nuclear phosphoproteins
  JOURNAL   Proc Natl Acad Sci U S A 101 (33), 12130-12135 (2004)
   PUBMED   15302935
REFERENCE   10 (bases 1 to 4964)
  AUTHORS   Puente,X.S., Sanchez,L.M., Overall,C.M. and Lopez-Otin,C.
  TITLE     Human and mouse proteases: a comparative genomic approach
  JOURNAL   Nat Rev Genet 4 (7), 544-558 (2003)
   PUBMED   12838346
  REMARK    Review article
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC135506.3.
            
            Summary: Protein ubiquitination controls many intracellular
            processes, including cell cycle progression, transcriptional
            activation, and signal transduction. This dynamic process,
            involving ubiquitin conjugating enzymes and deubiquitinating
            enzymes, adds and removes ubiquitin. Deubiquitinating enzymes are
            cysteine proteases that specifically cleave ubiquitin from
            ubiquitin-conjugated protein substrates. This protein is a
            ubiquitin protein ligase and plays a role in muscle wasting.
            Alternatively spliced transcript variants encoding different
            isoforms have been found for this gene. [provided by RefSeq, May
            2017].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038191.472712.1,
                                           SRR14038197.1669835.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-356               AC135506.3         50769-51124         c
            357-616             AC135506.3         49323-49582         c
            617-790             AC135506.3         48248-48421         c
            791-919             AC135506.3         47958-48086         c
            920-1053            AC135506.3         47738-47871         c
            1054-1356           AC135506.3         47360-47662         c
            1357-1573           AC135506.3         47028-47244         c
            1574-1730           AC135506.3         46752-46908         c
            1731-1802           AC135506.3         46581-46652         c
            1803-1918           AC135506.3         46348-46463         c
            1919-2139           AC135506.3         46025-46245         c
            2140-2335           AC135506.3         45745-45940         c
            2336-2469           AC135506.3         45529-45662         c
            2470-2628           AC135506.3         45260-45418         c
            2629-2739           AC135506.3         45064-45174         c
            2740-2850           AC135506.3         44475-44585         c
            2851-2952           AC135506.3         44293-44394         c
            2953-3093           AC135506.3         42790-42930         c
            3094-3212           AC135506.3         42585-42703         c
            3213-3350           AC135506.3         42212-42349         c
            3351-3664           AC135506.3         41801-42114         c
            3665-3775           AC135506.3         41556-41666         c
            3776-3992           AC135506.3         41251-41467         c
            3993-4145           AC135506.3         41012-41164         c
            4146-4306           AC135506.3         40745-40905         c
            4307-4485           AC135506.3         40485-40663         c
            4486-4964           AC135506.3         38351-38829         c
FEATURES             Location/Qualifiers
     source          1..4964
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3p21.31"
     gene            1..4964
                     /gene="USP19"
                     /gene_synonym="ZMYND9"
                     /note="ubiquitin specific peptidase 19"
                     /db_xref="GeneID:10869"
                     /db_xref="HGNC:HGNC:12617"
                     /db_xref="MIM:614471"
     exon            1..356
                     /gene="USP19"
                     /gene_synonym="ZMYND9"
                     /inference="alignment:Splign:2.1.0"
     exon            357..616
                     /gene="USP19"
                     /gene_synonym="ZMYND9"
                     /inference="alignment:Splign:2.1.0"
     CDS             493..4602
                     /gene="USP19"
                     /gene_synonym="ZMYND9"
                     /EC_number="3.4.19.12"
                     /note="isoform 14 is encoded by transcript variant 38;
                     ubiquitin specific protease 19; deubiquitinating enzyme
                     19; zinc finger MYND domain-containing protein 9;
                     ubiquitin-specific-processing protease 19; ubiquitin
                     carboxyl-terminal hydrolase 19; ubiquitin thioesterase 19;
                     ubiquitin thiolesterase 19"
                     /codon_start=1
                     /product="ubiquitin carboxyl-terminal hydrolase 19 isoform
                     14"
                     /protein_id="NP_001387226.1"
                     /db_xref="GeneID:10869"
                     /db_xref="HGNC:HGNC:12617"
                     /db_xref="MIM:614471"
                     /translation="MSGGASATGPRRGPPGLEDTTSKKKQKDRANQESKDGDPRKETG
                     SRYVAQAGLEPLASGDPSASASHAAGITGSRHRTRLFFPSSSGSASTPQEEQTKEELL
                     LDWRQSAEEVIVKLRVGVGPLQLEDVDAAFTDTDCVVRFAGGQQWGGVFYAEIKSSCA
                     KVQTRKGSLLHLTLPKKVPMLTWPSLLKKPLGTQELVPGLRCQENGQELSPIALEPGP
                     EPHRAKQEARNQKRAQGRGEVGAGAGPGAQAGPSAKRAVHLCRGPEGDGSRDDPGPRG
                     DAPPFVADPATQVEADEQLCIPPLNSQTCLLGSEENLAPLAGEKAVPPGNDPVSPAMV
                     RSRNPGKDDCAKEEMAVAADAATLVDEPESMVNLAFVKNDSYEKGPDSVVVHVYVKEI
                     CRDTSRVLFREQDFTLIFQTRDGNFLRLHPGCGPHTTFRWQVKLRNLIEPEQCTFCFT
                     ASRIDICLRKRQSQRWGGLEAPAARGAVGGAKVAVPTGPTPLDSTPPGGAPHPLTGQE
                     EARAVEKDKSKARSEDTGLDSVATRTPMEHVTPKPETHLASPKPTCMVPPMPHSPVSG
                     DSVEEEEEEEKKVCLPGFTGLVNLGNTCFMNSVIQSLSNTRELRDFFHDRSFEAEINY
                     NNPLGTGGRLAIGFAVLLRALWKGTHHAFQPSKLKAIVASKASQFTGYAQHDAQEFMA
                     FLLDGLHEDLNRIQNKPYTETVDSDGRPDEVVAEEAWQRHKMRNDSFIVDLFQGQYKS
                     KLVCPVCAKVSITFDPFLYLPVPLPQKQKVLPVFYFAREPHSKPIKFLVSVSKENSTA
                     SEVLDSLSQSVHVKPENLRLAEVIKNRFHRVFLPSHSLDTVSPSDTLLCFELLSSELA
                     KERVVVLEVQQRPQVPSVPISKCAACQRKQQSEDEKLKRCTRCYRVGYCNQLCQKTHW
                     PDHKGLCRPENIGYPFLVSVPASRLTYARLAQLLEGYARYSVSVFQPPFQPGRMALES
                     QSPGCTTLLSTGSLEAGDSERDPIQPPELQLVTPMAEGDTGLPRVWAAPDRGPVPSTS
                     GISSEMLASGPIEVGSLPAGERVSRPEAAVPGYQHPSEAMNAHTPQFFIYKIDSSNRE
                     QRLEDKGDTPLELGDDCSLALVWRNNERLQEFVLVASKELECAEDPGSAGEAARAGHF
                     TLDQCLNLFTRPEVLAPEEAWYCPQCKQHREASKQLLLWRLPNVLIVQLKRFSFRSFI
                     WRDKINDLVEFPVRNLDLSKFCIGQKEEQLPSYDLYAVINHYGGMIGGHYTACARLPN
                     DRSSQRSDVGWRLFDDSTVTTVDESQVVTRYAYVLFYRRRNSPVERPPRAGHSEHHPD
                     LGPAAEAAASQGLGPGQAPEVAPTRTAPERFAPPVDRPAPTYSNMEEVD"
     exon            617..790
                     /gene="USP19"
                     /gene_synonym="ZMYND9"
                     /inference="alignment:Splign:2.1.0"
     exon            791..919
                     /gene="USP19"
                     /gene_synonym="ZMYND9"
                     /inference="alignment:Splign:2.1.0"
     exon            920..1053
                     /gene="USP19"
                     /gene_synonym="ZMYND9"
                     /inference="alignment:Splign:2.1.0"
     exon            1054..1356
                     /gene="USP19"
                     /gene_synonym="ZMYND9"
                     /inference="alignment:Splign:2.1.0"
     exon            1357..1573
                     /gene="USP19"
                     /gene_synonym="ZMYND9"
                     /inference="alignment:Splign:2.1.0"
     exon            1574..1730
                     /gene="USP19"
                     /gene_synonym="ZMYND9"
                     /inference="alignment:Splign:2.1.0"
     exon            1731..1802
                     /gene="USP19"
                     /gene_synonym="ZMYND9"
                     /inference="alignment:Splign:2.1.0"
     exon            1803..1918
                     /gene="USP19"
                     /gene_synonym="ZMYND9"
                     /inference="alignment:Splign:2.1.0"
     exon            1919..2139
                     /gene="USP19"
                     /gene_synonym="ZMYND9"
                     /inference="alignment:Splign:2.1.0"
     exon            2140..2335
                     /gene="USP19"
                     /gene_synonym="ZMYND9"
                     /inference="alignment:Splign:2.1.0"
     exon            2336..2469
                     /gene="USP19"
                     /gene_synonym="ZMYND9"
                     /inference="alignment:Splign:2.1.0"
     exon            2470..2628
                     /gene="USP19"
                     /gene_synonym="ZMYND9"
                     /inference="alignment:Splign:2.1.0"
     exon            2629..2739
                     /gene="USP19"
                     /gene_synonym="ZMYND9"
                     /inference="alignment:Splign:2.1.0"
     exon            2740..2850
                     /gene="USP19"
                     /gene_synonym="ZMYND9"
                     /inference="alignment:Splign:2.1.0"
     exon            2851..2952
                     /gene="USP19"
                     /gene_synonym="ZMYND9"
                     /inference="alignment:Splign:2.1.0"
     exon            2953..3093
                     /gene="USP19"
                     /gene_synonym="ZMYND9"
                     /inference="alignment:Splign:2.1.0"
     exon            3094..3212
                     /gene="USP19"
                     /gene_synonym="ZMYND9"
                     /inference="alignment:Splign:2.1.0"
     exon            3213..3350
                     /gene="USP19"
                     /gene_synonym="ZMYND9"
                     /inference="alignment:Splign:2.1.0"
     exon            3351..3664
                     /gene="USP19"
                     /gene_synonym="ZMYND9"
                     /inference="alignment:Splign:2.1.0"
     exon            3665..3775
                     /gene="USP19"
                     /gene_synonym="ZMYND9"
                     /inference="alignment:Splign:2.1.0"
     exon            3776..3992
                     /gene="USP19"
                     /gene_synonym="ZMYND9"
                     /inference="alignment:Splign:2.1.0"
     exon            3993..4145
                     /gene="USP19"
                     /gene_synonym="ZMYND9"
                     /inference="alignment:Splign:2.1.0"
     exon            4146..4306
                     /gene="USP19"
                     /gene_synonym="ZMYND9"
                     /inference="alignment:Splign:2.1.0"
     exon            4307..4485
                     /gene="USP19"
                     /gene_synonym="ZMYND9"
                     /inference="alignment:Splign:2.1.0"
     exon            4486..4964
                     /gene="USP19"
                     /gene_synonym="ZMYND9"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4944..4949
                     /regulatory_class="polyA_signal_sequence"
                     /gene="USP19"
                     /gene_synonym="ZMYND9"
                     /note="hexamer: AATAAA"
     polyA_site      4964
                     /gene="USP19"
                     /gene_synonym="ZMYND9"
                     /note="major polyA site"
ORIGIN      
        1 gcgccggaac cggaacggag agcgggttgc cagggcccga agagggctgg ctgcggcggt
       61 ctcgctcggt gagtggagca ggctgcaact cgctggcttg gccgcagcgg ggaggccgca
      121 acgcgcggcc gcggcggcct gttcaaggtc acgggccgtg ccagtcccta cccctagtgc
      181 cccgcagcgt gccagcccac tgatgccggc agggccgtta cgctatgcct gtggccagcc
      241 tcccacctgg gagaggactg gcggccagcg agggcaactt cgtgggagag gtggtggcgg
      301 gctcggggtt cagaggctga agctgggtcg cagctcgacc ggggcgctga tctgtggctg
      361 tccgttcctt gctggagaat ttggccacaa agagttgcca agatagctgg gccaggaaga
      421 aagcgccgca gccctgaccc agacgctgtt gccgaccccg gggcactctg gctgtcgacc
      481 aagcggctca agatgtctgg cggggccagt gccacaggcc caaggagagg gcccccagga
      541 ctggaggaca ccactagtaa gaagaagcag aaggatcgag caaaccagga gagcaaggat
      601 ggagatccta ggaaagagac agggtctcga tatgttgccc aggctggtct tgaacctctg
      661 gcctcaggtg atccttctgc ctcagcctcc catgcagctg ggatcacagg ctcacgccac
      721 cgtacccggc tgttctttcc ttcatcgtca gggtcagcat ccactcctca agaggagcag
      781 accaaagagg agttgttgct cgattggagg cagagtgcag aagaggtgat tgtcaagctt
      841 cgtgtgggag taggtcccct gcagctggag gatgtagatg ctgctttcac agatacagac
      901 tgtgtggtgc ggtttgcagg tggtcagcag tggggtggtg tcttctatgc tgagataaaa
      961 agctcttgtg ctaaagtgca aacccgcaag ggcagtctcc tgcacctgac actgcccaaa
     1021 aaggtgccta tgctcacgtg gccctccctc ctgaagaaac ctctagggac ccaggagctg
     1081 gtgccggggc tgcggtgcca ggagaatggg caggaactgt ctcccattgc cctggagcca
     1141 ggccctgagc cccaccgggc taagcaggag gcccggaacc agaagcgggc ccagggccgt
     1201 ggtgaggtag gcgcaggggc tggccccggg gcccaggcag ggcccagcgc caagagggct
     1261 gtgcatctct gcagagggcc agagggggac gggtccaggg atgaccctgg accccggggt
     1321 gatgccccac ccttcgtggc tgacccagcc acccaggttg aggctgatga acagctttgc
     1381 ataccaccgc tgaactccca aacctgcctc ctgggctcag aggagaattt agcccctttg
     1441 gcaggagaga aagcagtgcc tcccgggaat gacccagtct ctccagccat ggtccggagc
     1501 agaaaccctg ggaaagatga ctgtgccaag gaggagatgg cagtggcagc agatgctgca
     1561 accttggtgg atgagcccga gtcgatggtg aacctggcgt ttgtcaagaa tgactcgtat
     1621 gagaagggcc cggattcagt ggtggtgcac gtgtacgtga aggagatctg cagggacacc
     1681 tcaagagtac ttttccgtga gcaggacttc acgctcatct tccagaccag ggatggaaac
     1741 ttcctgaggc tgcacccggg ctgtgggccc cacaccacct tccgttggca ggtgaagctc
     1801 aggaatctga ttgagccaga gcagtgcacc ttctgtttca cggcttctcg catcgacatc
     1861 tgccttcgta agaggcagag tcagcgctgg gggggcctgg aggccccggc tgcacgaggt
     1921 gcagtgggtg gtgcaaaggt tgccgtgccg acaggtccaa cccctctgga ttcaacccca
     1981 ccaggaggtg ctccccaccc cctgacaggc caggaggagg cccgggctgt ggagaaggat
     2041 aaatccaagg cacgatctga ggacacaggg ctagacagtg tggcaacccg cacacccatg
     2101 gagcatgtaa ccccaaagcc agagacacac ctggcctcgc ccaagcctac atgcatggtg
     2161 cctcccatgc cccacagccc agttagtgga gacagcgtgg aggaggagga agaggaagag
     2221 aagaaggtgt gtctgccagg cttcactggc cttgtcaatt taggcaacac ctgcttcatg
     2281 aacagcgtca ttcagtctct gtccaacact cgggaactcc gggacttctt ccatgaccgc
     2341 tcctttgagg ctgagatcaa ctacaacaac ccactaggga ctggtgggcg tctggccatt
     2401 ggctttgccg tgctgcttcg ggcgctgtgg aagggcaccc accatgcctt ccagccttcc
     2461 aagttgaagg ccattgtggc gagtaaggcc agccagttca caggctatgc acagcatgat
     2521 gcccaggagt tcatggcttt cctgctggat gggctgcacg aggacctgaa tcgcattcag
     2581 aacaagccct acacagagac cgtggattca gatgggcggc ccgatgaggt ggtagctgag
     2641 gaagcatggc agcggcacaa gatgaggaat gactctttca tcgtggacct atttcagggg
     2701 cagtacaagt cgaagctggt gtgccctgtg tgtgccaagg tctccatcac ttttgacccg
     2761 tttctttatc tgccggtgcc cttgccacaa aagcaaaagg ttctccctgt cttttatttt
     2821 gcccgagagc cccacagcaa gcccatcaag ttcctggtga gcgtcagcaa ggagaactcc
     2881 actgcgagcg aagtattgga ctccctctct cagagtgttc atgtgaagcc tgagaacctg
     2941 cgtttggcgg aggtaattaa gaatcgtttt catcgtgtgt tcctaccctc ccactcactg
     3001 gacactgtgt ccccatctga tacgctcctc tgctttgagc tgctatcctc agagttggct
     3061 aaggagcggg tagtggtgct agaggtgcaa cagcgccccc aggtgcccag cgtccccatc
     3121 tccaagtgtg cagcctgcca gcggaagcaa cagtcggagg atgaaaagct gaagcgctgt
     3181 acccggtgct accgtgtggg ctactgcaac cagctctgcc agaaaaccca ctggcctgac
     3241 cacaagggcc tctgccgacc tgagaacatt ggctacccct tcctggtcag tgtacctgcc
     3301 tcacgcctca cttatgcccg cctcgctcag ttgctagagg gctatgcccg gtactctgtg
     3361 agtgtattcc agccaccctt tcagccaggc cgcatggcct tggagtctca gagccctggc
     3421 tgcaccacac tgctctccac aggttccctg gaggctgggg acagcgagag agaccccatt
     3481 cagccacctg agctccagct ggtgacccct atggctgagg gggacacagg gcttccccgg
     3541 gtgtgggcag cccctgaccg gggtcctgtg cccagcacca gtggaatttc ttctgagatg
     3601 ctggccagtg ggcccattga ggttggctcc ttgccagctg gcgagagggt gtcccgaccc
     3661 gaagctgctg tgcctgggta ccagcatcca agtgaagcta tgaatgccca cacaccccag
     3721 ttcttcatct ataaaattga ttcatccaac cgagagcagc ggctagagga caaaggagac
     3781 accccactgg agctgggtga cgactgtagc ctggctctcg tctggcggaa caatgagcgc
     3841 ttgcaggagt ttgtgttggt agcctccaag gagctggaat gtgctgagga tccaggctct
     3901 gccggtgagg ctgcccgggc cggccacttc accctggacc agtgcctcaa cctcttcaca
     3961 cggcctgagg tgctggcacc cgaggaggcc tggtactgcc cacagtgcaa acagcaccgt
     4021 gaggcctcca agcagctgtt gctatggcgc ctgccaaatg ttctcatcgt gcagctcaag
     4081 cgcttctcct ttcgtagttt tatctggcgt gacaagatca atgacttggt ggagttccct
     4141 gttaggaacc tggacctgag caagttctgc attggtcaga aagaggagca gctgcccagc
     4201 tacgatctat atgctgtcat caaccactat ggaggcatga ttggtggcca ctacactgcc
     4261 tgtgcacgcc tgcccaatga tcgtagcagt cagcgcagtg acgtgggctg gcgcttgttt
     4321 gatgacagca cagtgacaac ggtagacgag agccaggttg tgacgcgtta tgcctatgta
     4381 ctcttctacc gccggcggaa ctctcctgtg gagaggcccc ccagggcagg tcactctgag
     4441 caccacccag acctaggccc tgcagctgag gctgctgcca gccagggact aggccctggc
     4501 caggcccccg aggtggcccc cacgcggaca gcccctgaac gcttcgcccc ccctgtggat
     4561 cggccagccc ccacctacag caacatggag gaggtggatt agcaggtccc tggctgatgg
     4621 gggggactgg gtttgggaca cccacacaga gggccagctc cttgccgctt ctccttctct
     4681 aacccagagg acactggctc tgtcaatggg aagctgaggg gtatgatttg ggtgtggaga
     4741 cctctcaggt tgggacttct tgtcagcttg gacccctgac cagtgggctt tggcttctcc
     4801 agccgcctcc agtgctgcgt gatttgattc tgttgtacct tcaattcttc tgacccgcat
     4861 tataaacatt ataattttat tctaaaaatt gtaatttttt ttgcattttg gaagtgactg
     4921 ctgctgttta aatatatttt aaaaataaat aataagtaag taga
//
