LOCUS       NM_001351103            4418 bp    mRNA    linear   PRI 17-SEP-2024
DEFINITION  Homo sapiens ubiquitin specific peptidase 19 (USP19), transcript
            variant 10, mRNA.
ACCESSION   NM_001351103 XM_017005632
VERSION     NM_001351103.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4418)
  AUTHORS   Yu,W., Zhuang,S., Zhan,M., Chen,Y., Zhang,J., Chen,L., Tu,C.,
            Zheng,L. and Chen,S.
  TITLE     Deubiquitinating Enzyme USP19 Regulates Ferroptosis and
            Mitochondrial Damage in SH-SY5Y Cells by Targeting the NOX4 Protein
  JOURNAL   J Alzheimers Dis 100 (3), 799-808 (2024)
   PUBMED   38943386
  REMARK    GeneRIF: Deubiquitinating Enzyme USP19 Regulates Ferroptosis and
            Mitochondrial Damage in SH-SY5Y Cells by Targeting the NOX4
            Protein.
REFERENCE   2  (bases 1 to 4418)
  AUTHORS   Tian,Z., Xu,C., He,W., Lin,Z., Zhang,W., Tao,K., Ding,R., Zhang,X.
            and Dou,K.
  TITLE     The deubiquitinating enzyme USP19 facilitates hepatocellular
            carcinoma progression through stabilizing YAP
  JOURNAL   Cancer Lett 577, 216439 (2023)
   PUBMED   37832781
  REMARK    GeneRIF: The deubiquitinating enzyme USP19 facilitates
            hepatocellular carcinoma progression through stabilizing YAP.
REFERENCE   3  (bases 1 to 4418)
  AUTHORS   Zhang,J., van Dinther,M., Thorikay,M., Gourabi,B.M.,
            Kruithof,B.P.T. and Ten Dijke,P.
  TITLE     Opposing USP19 splice variants in TGF-beta signaling and
            TGF-beta-induced epithelial-mesenchymal transition of breast cancer
            cells
  JOURNAL   Cell Mol Life Sci 80 (2), 43 (2023)
   PUBMED   36646950
  REMARK    GeneRIF: Opposing USP19 splice variants in TGF-beta signaling and
            TGF-beta-induced epithelial-mesenchymal transition of breast cancer
            cells.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4418)
  AUTHORS   Sarodaya,N., Tyagi,A., Kim,H.J., Kang,J.S., Singh,V., Hong,S.H.,
            Kim,W.J., Kim,K.S. and Ramakrishna,S.
  TITLE     Deubiquitinase USP19 extends the residual enzymatic activity of
            phenylalanine hydroxylase variants
  JOURNAL   Sci Rep 12 (1), 14243 (2022)
   PUBMED   35987969
  REMARK    GeneRIF: Deubiquitinase USP19 extends the residual enzymatic
            activity of phenylalanine hydroxylase variants.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4418)
  AUTHORS   Chevalier,B., Baatallah,N., Najm,M., Castanier,S., Jung,V.,
            Pranke,I., Golec,A., Stoven,V., Marullo,S., Antigny,F.,
            Guerrera,I.C., Sermet-Gaudelus,I., Edelman,A. and Hinzpeter,A.
  TITLE     Differential CFTR-Interactome Proximity Labeling Procedures
            Identify Enrichment in Multiple SLC Transporters
  JOURNAL   Int J Mol Sci 23 (16), 8937 (2022)
   PUBMED   36012204
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4418)
  AUTHORS   Mei,Y., Hahn,A.A., Hu,S. and Yang,X.
  TITLE     The USP19 deubiquitinase regulates the stability of c-IAP1 and
            c-IAP2
  JOURNAL   J Biol Chem 286 (41), 35380-35387 (2011)
   PUBMED   21849505
  REMARK    GeneRIF: The USP19 deubiquitinase regulates the stability of c-IAP1
            and c-IAP2.
REFERENCE   7  (bases 1 to 4418)
  AUTHORS   Lu,Y., Bedard,N., Chevalier,S. and Wing,S.S.
  TITLE     Identification of distinctive patterns of USP19-mediated growth
            regulation in normal and malignant cells
  JOURNAL   PLoS One 6 (1), e15936 (2011)
   PUBMED   21264218
  REMARK    GeneRIF: ability of USP19 to regulate cell proliferation and
            p27(Kip1) levels; complete loss of USP19 function on cell growth
            may arise as a result of oncogenic transformation of cells.
            Publication Status: Online-Only
REFERENCE   8  (bases 1 to 4418)
  AUTHORS   Hassink,G.C., Zhao,B., Sompallae,R., Altun,M., Gastaldello,S.,
            Zinin,N.V., Masucci,M.G. and Lindsten,K.
  TITLE     The ER-resident ubiquitin-specific protease 19 participates in the
            UPR and rescues ERAD substrates
  JOURNAL   EMBO Rep 10 (7), 755-761 (2009)
   PUBMED   19465887
  REMARK    GeneRIF: USP19 is the first example of a membrane-anchored
            deubiquitinating enzymes involved in the turnover of
            endoplasmic-reticulum-associated degradation substrates.
REFERENCE   9  (bases 1 to 4418)
  AUTHORS   Beausoleil,S.A., Jedrychowski,M., Schwartz,D., Elias,J.E.,
            Villen,J., Li,J., Cohn,M.A., Cantley,L.C. and Gygi,S.P.
  TITLE     Large-scale characterization of HeLa cell nuclear phosphoproteins
  JOURNAL   Proc Natl Acad Sci U S A 101 (33), 12130-12135 (2004)
   PUBMED   15302935
REFERENCE   10 (bases 1 to 4418)
  AUTHORS   Puente,X.S., Sanchez,L.M., Overall,C.M. and Lopez-Otin,C.
  TITLE     Human and mouse proteases: a comparative genomic approach
  JOURNAL   Nat Rev Genet 4 (7), 544-558 (2003)
   PUBMED   12838346
  REMARK    Review article
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC135506.3.
            
            On Aug 13, 2020 this sequence version replaced NM_001351103.1.
            
            Summary: Protein ubiquitination controls many intracellular
            processes, including cell cycle progression, transcriptional
            activation, and signal transduction. This dynamic process,
            involving ubiquitin conjugating enzymes and deubiquitinating
            enzymes, adds and removes ubiquitin. Deubiquitinating enzymes are
            cysteine proteases that specifically cleave ubiquitin from
            ubiquitin-conjugated protein substrates. This protein is a
            ubiquitin protein ligase and plays a role in muscle wasting.
            Alternatively spliced transcript variants encoding different
            isoforms have been found for this gene. [provided by RefSeq, May
            2017].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038191.3505143.1,
                                           SRR18074969.3685547.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-68                AC135506.3         51057-51124         c
            69-328              AC135506.3         49323-49582         c
            329-502             AC135506.3         48248-48421         c
            503-676             AC135506.3         47958-48131         c
            677-810             AC135506.3         47738-47871         c
            811-1033            AC135506.3         47022-47244         c
            1034-1190           AC135506.3         46752-46908         c
            1191-1262           AC135506.3         46581-46652         c
            1263-1378           AC135506.3         46348-46463         c
            1379-1593           AC135506.3         46025-46239         c
            1594-1789           AC135506.3         45745-45940         c
            1790-1923           AC135506.3         45529-45662         c
            1924-2082           AC135506.3         45260-45418         c
            2083-2193           AC135506.3         45064-45174         c
            2194-2304           AC135506.3         44475-44585         c
            2305-2406           AC135506.3         44293-44394         c
            2407-2547           AC135506.3         42790-42930         c
            2548-2666           AC135506.3         42585-42703         c
            2667-2804           AC135506.3         42212-42349         c
            2805-3118           AC135506.3         41801-42114         c
            3119-3229           AC135506.3         41556-41666         c
            3230-3446           AC135506.3         41251-41467         c
            3447-3599           AC135506.3         41012-41164         c
            3600-3760           AC135506.3         40745-40905         c
            3761-3939           AC135506.3         40485-40663         c
            3940-4418           AC135506.3         38351-38829         c
FEATURES             Location/Qualifiers
     source          1..4418
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3p21.31"
     gene            1..4418
                     /gene="USP19"
                     /gene_synonym="ZMYND9"
                     /note="ubiquitin specific peptidase 19"
                     /db_xref="GeneID:10869"
                     /db_xref="HGNC:HGNC:12617"
                     /db_xref="MIM:614471"
     exon            1..68
                     /gene="USP19"
                     /gene_synonym="ZMYND9"
                     /inference="alignment:Splign:2.1.0"
     exon            69..328
                     /gene="USP19"
                     /gene_synonym="ZMYND9"
                     /inference="alignment:Splign:2.1.0"
     CDS             205..4056
                     /gene="USP19"
                     /gene_synonym="ZMYND9"
                     /EC_number="3.4.19.12"
                     /note="isoform 10 is encoded by transcript variant 10;
                     ubiquitin specific protease 19; deubiquitinating enzyme
                     19; zinc finger MYND domain-containing protein 9;
                     ubiquitin-specific-processing protease 19; ubiquitin
                     carboxyl-terminal hydrolase 19; ubiquitin thioesterase 19;
                     ubiquitin thiolesterase 19"
                     /codon_start=1
                     /product="ubiquitin carboxyl-terminal hydrolase 19 isoform
                     10"
                     /protein_id="NP_001338032.1"
                     /db_xref="GeneID:10869"
                     /db_xref="HGNC:HGNC:12617"
                     /db_xref="MIM:614471"
                     /translation="MSGGASATGPRRGPPGLEDTTSKKKQKDRANQESKDGDPRKETG
                     SRYVAQAGLEPLASGDPSASASHAAGITGSRHRTRLFFPSSSGSASTPQEEQTKEGAC
                     EDPHDLLATPTPELLLDWRQSAEEVIVKLRVGVGPLQLEDVDAAFTDTDCVVRFAGGQ
                     QWGGVFYAEIKSSCAKVQTRKGSLLHLTLPKKVPMLTWPSLLVEADEQLCIPPLNSQT
                     CLLGSEENLAPLAGEKAVPPGNDPVSPAMVRSRNPGKDDCAKEEMAVAADAATLVDGK
                     EPESMVNLAFVKNDSYEKGPDSVVVHVYVKEICRDTSRVLFREQDFTLIFQTRDGNFL
                     RLHPGCGPHTTFRWQVKLRNLIEPEQCTFCFTASRIDICLRKRQSQRWGGLEAPAARV
                     GGAKVAVPTGPTPLDSTPPGGAPHPLTGQEEARAVEKDKSKARSEDTGLDSVATRTPM
                     EHVTPKPETHLASPKPTCMVPPMPHSPVSGDSVEEEEEEEKKVCLPGFTGLVNLGNTC
                     FMNSVIQSLSNTRELRDFFHDRSFEAEINYNNPLGTGGRLAIGFAVLLRALWKGTHHA
                     FQPSKLKAIVASKASQFTGYAQHDAQEFMAFLLDGLHEDLNRIQNKPYTETVDSDGRP
                     DEVVAEEAWQRHKMRNDSFIVDLFQGQYKSKLVCPVCAKVSITFDPFLYLPVPLPQKQ
                     KVLPVFYFAREPHSKPIKFLVSVSKENSTASEVLDSLSQSVHVKPENLRLAEVIKNRF
                     HRVFLPSHSLDTVSPSDTLLCFELLSSELAKERVVVLEVQQRPQVPSVPISKCAACQR
                     KQQSEDEKLKRCTRCYRVGYCNQLCQKTHWPDHKGLCRPENIGYPFLVSVPASRLTYA
                     RLAQLLEGYARYSVSVFQPPFQPGRMALESQSPGCTTLLSTGSLEAGDSERDPIQPPE
                     LQLVTPMAEGDTGLPRVWAAPDRGPVPSTSGISSEMLASGPIEVGSLPAGERVSRPEA
                     AVPGYQHPSEAMNAHTPQFFIYKIDSSNREQRLEDKGDTPLELGDDCSLALVWRNNER
                     LQEFVLVASKELECAEDPGSAGEAARAGHFTLDQCLNLFTRPEVLAPEEAWYCPQCKQ
                     HREASKQLLLWRLPNVLIVQLKRFSFRSFIWRDKINDLVEFPVRNLDLSKFCIGQKEE
                     QLPSYDLYAVINHYGGMIGGHYTACARLPNDRSSQRSDVGWRLFDDSTVTTVDESQVV
                     TRYAYVLFYRRRNSPVERPPRAGHSEHHPDLGPAAEAAASQGLGPGQAPEVAPTRTAP
                     ERFAPPVDRPAPTYSNMEEVD"
     exon            329..502
                     /gene="USP19"
                     /gene_synonym="ZMYND9"
                     /inference="alignment:Splign:2.1.0"
     exon            503..676
                     /gene="USP19"
                     /gene_synonym="ZMYND9"
                     /inference="alignment:Splign:2.1.0"
     exon            677..810
                     /gene="USP19"
                     /gene_synonym="ZMYND9"
                     /inference="alignment:Splign:2.1.0"
     exon            811..1033
                     /gene="USP19"
                     /gene_synonym="ZMYND9"
                     /inference="alignment:Splign:2.1.0"
     exon            1034..1190
                     /gene="USP19"
                     /gene_synonym="ZMYND9"
                     /inference="alignment:Splign:2.1.0"
     exon            1191..1262
                     /gene="USP19"
                     /gene_synonym="ZMYND9"
                     /inference="alignment:Splign:2.1.0"
     exon            1263..1378
                     /gene="USP19"
                     /gene_synonym="ZMYND9"
                     /inference="alignment:Splign:2.1.0"
     exon            1379..1593
                     /gene="USP19"
                     /gene_synonym="ZMYND9"
                     /inference="alignment:Splign:2.1.0"
     exon            1594..1789
                     /gene="USP19"
                     /gene_synonym="ZMYND9"
                     /inference="alignment:Splign:2.1.0"
     exon            1790..1923
                     /gene="USP19"
                     /gene_synonym="ZMYND9"
                     /inference="alignment:Splign:2.1.0"
     exon            1924..2082
                     /gene="USP19"
                     /gene_synonym="ZMYND9"
                     /inference="alignment:Splign:2.1.0"
     exon            2083..2193
                     /gene="USP19"
                     /gene_synonym="ZMYND9"
                     /inference="alignment:Splign:2.1.0"
     exon            2194..2304
                     /gene="USP19"
                     /gene_synonym="ZMYND9"
                     /inference="alignment:Splign:2.1.0"
     exon            2305..2406
                     /gene="USP19"
                     /gene_synonym="ZMYND9"
                     /inference="alignment:Splign:2.1.0"
     exon            2407..2547
                     /gene="USP19"
                     /gene_synonym="ZMYND9"
                     /inference="alignment:Splign:2.1.0"
     exon            2548..2666
                     /gene="USP19"
                     /gene_synonym="ZMYND9"
                     /inference="alignment:Splign:2.1.0"
     exon            2667..2804
                     /gene="USP19"
                     /gene_synonym="ZMYND9"
                     /inference="alignment:Splign:2.1.0"
     exon            2805..3118
                     /gene="USP19"
                     /gene_synonym="ZMYND9"
                     /inference="alignment:Splign:2.1.0"
     exon            3119..3229
                     /gene="USP19"
                     /gene_synonym="ZMYND9"
                     /inference="alignment:Splign:2.1.0"
     exon            3230..3446
                     /gene="USP19"
                     /gene_synonym="ZMYND9"
                     /inference="alignment:Splign:2.1.0"
     exon            3447..3599
                     /gene="USP19"
                     /gene_synonym="ZMYND9"
                     /inference="alignment:Splign:2.1.0"
     exon            3600..3760
                     /gene="USP19"
                     /gene_synonym="ZMYND9"
                     /inference="alignment:Splign:2.1.0"
     exon            3761..3939
                     /gene="USP19"
                     /gene_synonym="ZMYND9"
                     /inference="alignment:Splign:2.1.0"
     exon            3940..4418
                     /gene="USP19"
                     /gene_synonym="ZMYND9"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4398..4403
                     /regulatory_class="polyA_signal_sequence"
                     /gene="USP19"
                     /gene_synonym="ZMYND9"
                     /note="hexamer: AATAAA"
     polyA_site      4418
                     /gene="USP19"
                     /gene_synonym="ZMYND9"
                     /note="major polyA site"
ORIGIN      
        1 gcgccggaac cggaacggag agcgggttgc cagggcccga agagggctgg ctgcggcggt
       61 ctcgctcggc tgtccgttcc ttgctggaga atttggccac aaagagttgc caagatagct
      121 gggccaggaa gaaagcgccg cagccctgac ccagacgctg ttgccgaccc cggggcactc
      181 tggctgtcga ccaagcggct caagatgtct ggcggggcca gtgccacagg cccaaggaga
      241 gggcccccag gactggagga caccactagt aagaagaagc agaaggatcg agcaaaccag
      301 gagagcaagg atggagatcc taggaaagag acagggtctc gatatgttgc ccaggctggt
      361 cttgaacctc tggcctcagg tgatccttct gcctcagcct cccatgcagc tgggatcaca
      421 ggctcacgcc accgtacccg gctgttcttt ccttcatcgt cagggtcagc atccactcct
      481 caagaggagc agaccaaaga gggagcttgt gaagaccctc atgatctctt ggctactccc
      541 actccagagt tgttgctcga ttggaggcag agtgcagaag aggtgattgt caagcttcgt
      601 gtgggagtag gtcccctgca gctggaggat gtagatgctg ctttcacaga tacagactgt
      661 gtggtgcggt ttgcaggtgg tcagcagtgg ggtggtgtct tctatgctga gataaaaagc
      721 tcttgtgcta aagtgcaaac ccgcaagggc agtctcctgc acctgacact gcccaaaaag
      781 gtgcctatgc tcacgtggcc ctccctcctg gttgaggctg atgaacagct ttgcatacca
      841 ccgctgaact cccaaacctg cctcctgggc tcagaggaga atttagcccc tttggcagga
      901 gagaaagcag tgcctcccgg gaatgaccca gtctctccag ccatggtccg gagcagaaac
      961 cctgggaaag atgactgtgc caaggaggag atggcagtgg cagcagatgc tgcaaccttg
     1021 gtggatggta aagagcccga gtcgatggtg aacctggcgt ttgtcaagaa tgactcgtat
     1081 gagaagggcc cggattcagt ggtggtgcac gtgtacgtga aggagatctg cagggacacc
     1141 tcaagagtac ttttccgtga gcaggacttc acgctcatct tccagaccag ggatggaaac
     1201 ttcctgaggc tgcacccggg ctgtgggccc cacaccacct tccgttggca ggtgaagctc
     1261 aggaatctga ttgagccaga gcagtgcacc ttctgtttca cggcttctcg catcgacatc
     1321 tgccttcgta agaggcagag tcagcgctgg gggggcctgg aggccccggc tgcacgagtg
     1381 ggtggtgcaa aggttgccgt gccgacaggt ccaacccctc tggattcaac cccaccagga
     1441 ggtgctcccc accccctgac aggccaggag gaggcccggg ctgtggagaa ggataaatcc
     1501 aaggcacgat ctgaggacac agggctagac agtgtggcaa cccgcacacc catggagcat
     1561 gtaaccccaa agccagagac acacctggcc tcgcccaagc ctacatgcat ggtgcctccc
     1621 atgccccaca gcccagttag tggagacagc gtggaggagg aggaagagga agagaagaag
     1681 gtgtgtctgc caggcttcac tggccttgtc aatttaggca acacctgctt catgaacagc
     1741 gtcattcagt ctctgtccaa cactcgggaa ctccgggact tcttccatga ccgctccttt
     1801 gaggctgaga tcaactacaa caacccacta gggactggtg ggcgtctggc cattggcttt
     1861 gccgtgctgc ttcgggcgct gtggaagggc acccaccatg ccttccagcc ttccaagttg
     1921 aaggccattg tggcgagtaa ggccagccag ttcacaggct atgcacagca tgatgcccag
     1981 gagttcatgg ctttcctgct ggatgggctg cacgaggacc tgaatcgcat tcagaacaag
     2041 ccctacacag agaccgtgga ttcagatggg cggcccgatg aggtggtagc tgaggaagca
     2101 tggcagcggc acaagatgag gaatgactct ttcatcgtgg acctatttca ggggcagtac
     2161 aagtcgaagc tggtgtgccc tgtgtgtgcc aaggtctcca tcacttttga cccgtttctt
     2221 tatctgccgg tgcccttgcc acaaaagcaa aaggttctcc ctgtctttta ttttgcccga
     2281 gagccccaca gcaagcccat caagttcctg gtgagcgtca gcaaggagaa ctccactgcg
     2341 agcgaagtat tggactccct ctctcagagt gttcatgtga agcctgagaa cctgcgtttg
     2401 gcggaggtaa ttaagaatcg ttttcatcgt gtgttcctac cctcccactc actggacact
     2461 gtgtccccat ctgatacgct cctctgcttt gagctgctat cctcagagtt ggctaaggag
     2521 cgggtagtgg tgctagaggt gcaacagcgc ccccaggtgc ccagcgtccc catctccaag
     2581 tgtgcagcct gccagcggaa gcaacagtcg gaggatgaaa agctgaagcg ctgtacccgg
     2641 tgctaccgtg tgggctactg caaccagctc tgccagaaaa cccactggcc tgaccacaag
     2701 ggcctctgcc gacctgagaa cattggctac cccttcctgg tcagtgtacc tgcctcacgc
     2761 ctcacttatg cccgcctcgc tcagttgcta gagggctatg cccggtactc tgtgagtgta
     2821 ttccagccac cctttcagcc aggccgcatg gccttggagt ctcagagccc tggctgcacc
     2881 acactgctct ccacaggttc cctggaggct ggggacagcg agagagaccc cattcagcca
     2941 cctgagctcc agctggtgac ccctatggct gagggggaca cagggcttcc ccgggtgtgg
     3001 gcagcccctg accggggtcc tgtgcccagc accagtggaa tttcttctga gatgctggcc
     3061 agtgggccca ttgaggttgg ctccttgcca gctggcgaga gggtgtcccg acccgaagct
     3121 gctgtgcctg ggtaccagca tccaagtgaa gctatgaatg cccacacacc ccagttcttc
     3181 atctataaaa ttgattcatc caaccgagag cagcggctag aggacaaagg agacacccca
     3241 ctggagctgg gtgacgactg tagcctggct ctcgtctggc ggaacaatga gcgcttgcag
     3301 gagtttgtgt tggtagcctc caaggagctg gaatgtgctg aggatccagg ctctgccggt
     3361 gaggctgccc gggccggcca cttcaccctg gaccagtgcc tcaacctctt cacacggcct
     3421 gaggtgctgg cacccgagga ggcctggtac tgcccacagt gcaaacagca ccgtgaggcc
     3481 tccaagcagc tgttgctatg gcgcctgcca aatgttctca tcgtgcagct caagcgcttc
     3541 tcctttcgta gttttatctg gcgtgacaag atcaatgact tggtggagtt ccctgttagg
     3601 aacctggacc tgagcaagtt ctgcattggt cagaaagagg agcagctgcc cagctacgat
     3661 ctatatgctg tcatcaacca ctatggaggc atgattggtg gccactacac tgcctgtgca
     3721 cgcctgccca atgatcgtag cagtcagcgc agtgacgtgg gctggcgctt gtttgatgac
     3781 agcacagtga caacggtaga cgagagccag gttgtgacgc gttatgccta tgtactcttc
     3841 taccgccggc ggaactctcc tgtggagagg ccccccaggg caggtcactc tgagcaccac
     3901 ccagacctag gccctgcagc tgaggctgct gccagccagg gactaggccc tggccaggcc
     3961 cccgaggtgg cccccacgcg gacagcccct gaacgcttcg ccccccctgt ggatcggcca
     4021 gcccccacct acagcaacat ggaggaggtg gattagcagg tccctggctg atggggggga
     4081 ctgggtttgg gacacccaca cagagggcca gctccttgcc gcttctcctt ctctaaccca
     4141 gaggacactg gctctgtcaa tgggaagctg aggggtatga tttgggtgtg gagacctctc
     4201 aggttgggac ttcttgtcag cttggacccc tgaccagtgg gctttggctt ctccagccgc
     4261 ctccagtgct gcgtgatttg attctgttgt accttcaatt cttctgaccc gcattataaa
     4321 cattataatt ttattctaaa aattgtaatt ttttttgcat tttggaagtg actgctgctg
     4381 tttaaatata ttttaaaaat aaataataag taagtaga
//
